Dr. Irfan Ali Khan, PhD - Nanobiotechnology, Cancer Biology, Molecular Biology, Bioassay and Toxicology - Research Scientist

Dr. Irfan Ali Khan

PhD

Nanobiotechnology, Cancer Biology, Molecular Biology, Bioassay and Toxicology

Research Scientist

Albany, New York | United States

Dr. Irfan Ali Khan, PhD - Nanobiotechnology, Cancer Biology, Molecular Biology, Bioassay and Toxicology - Research Scientist

Dr. Irfan Ali Khan

PhD

Introduction

I am a post-doctoral scientist in the Department of Chemistry and the RNA Institute at the State University of New York at Albany. I am currently working in the laboratory of Dr. Royzen and I am co-mentored by Dr. Yigit. My research focuses on the development of nanoparticle-based drug delivery systems, capable of controlled drug activation using bio-orthogonal chemistry. I have extensive experience in many biochemical techniques, including flow cytometry, qRT-PCR, and Western Blot analysis. I am also experienced at conducting cell-based assays, such as MTT, transfection, and immunohistochemistry. As a graduate student at Baqai Medical University and during my prior appointment at Albany Medical College I have been trained at conducting in vivo research using vertebrate animals.

Primary Affiliation: Nanobiotechnology, Cancer Biology, Molecular Biology, Bioassay and Toxicology - Albany, New York , United States

Research Interests:


View Dr. Irfan Ali Khan’s Resume / CV

Metrics

Number of Publications

11

Publications

Number of Profile Views

410

Profile Views

Number of Article Reads

43

Reads

Number of PubMed Central Citations

44

PubMed Central Citations

Education

Sep 2014
University at Albany
Post-Doc
Oct 2012
Albany Medical College
Post-Doc
Jul 2012
University of Karachi
PhD
Jun 2005
University of Karachi
MSc
Jan 2000
Baqai Medical University
BSc

Experience

Jan 2017
The RNA Institute, University at Albany, SUNY, Travel Award
Presenter
Jan 2017
The GRC RNA Nanotechnology, Travel Award
Presenter
Oct 2015
The RNA Institute, University at Albany, SUNY, Travel Award
Presenter
Sep 2010
Research Grant, U.S. Department of State
Principal Investigator
Jun 2009
Research Grant, pre-doctoral training at NYMC
Principal Investigator
Jul 2007
Research Grant Award
Co-Principal Investigator

Top co-authors

Sammer Siddiqui
Sammer Siddiqui

The Aga Khan University

2
Maksim Royzen
Maksim Royzen

New York University

2
Mehmet V Yigit
Mehmet V Yigit

Harvard Medical School

2
Sadiq Rehmani
Sadiq Rehmani

Mount Sinai St. Luke's Hospital

1
Shahana U Kazmi
Shahana U Kazmi

University of Karachi

1
Syed Ali
Syed Ali

Aga Khan University Hospital

1
Shamshad Zarina
Shamshad Zarina

University of Karachi

1
Syed H Ali
Syed H Ali

Aga Khan University

1
Jason M MacKenzie
Jason M MacKenzie

University of Melbourne

1
Kouacou V Konan
Kouacou V Konan

University Park

1

Publications

11Publications

43Reads

44PubMed Central Citations

In Vivo Bioorthogonal Chemistry Enables Local Hydrogel and Systemic Pro-Drug To Treat Soft Tissue Sarcoma.

ACS Cent Sci 2016 Jul 13;2(7):476-82. Epub 2016 Jul 13.

University at Albany , Department of Chemistry, 1400 Washington Avenue, Albany, New York 12222, United States.

View Article
July 2016
4 Reads
10 PubMed Central Citations(source)

In situ activation of a doxorubicin prodrug using imaging-capable nanoparticles.

Chem Commun (Camb) 2016 05 14;52(36):6174-7. Epub 2016 Apr 14.

Department of Chemistry and The RNA Institute, University at Albany, State University of New York, 1400 Washington Ave., Albany, NY 12222, USA.

View Article
May 2016
9 Reads
1 PubMed Central Citation(source)
6.830 Impact Factor

Reprogrammable multiplexed detection of circulating oncomiRs using hybridization chain reaction.

Chem Commun (Camb) 2016 Feb 3;52(17):3524-7. Epub 2016 Feb 3.

Department of Chemistry, University at Albany, State University of New York, 1400 Washington Avenue, Albany, New York 12222, USA.

View Article
February 2016
5 Reads
2 PubMed Central Citations(source)
6.830 Impact Factor

Current Pattern of Antibiotic Resistance in Clinical Isolates of Acinetobacter Baumannii from Intensive Care Units of Tertiary Care Hospital.

(AKEMU [S.l.], v. 22, n. 1)

Annals of King Edward Medical University

Purpose: To determine the pattern of antibiotic resistance in clinical isolates of Acinetobacter baumannii from ICU’s of tertiary care hospital in Karachi. Study Design: A case control study. Methods: Three hundred and fifteen clinical isolates of Acinetobacter baumannii collected from different ICUs were evaluated during 1 year period. The isolates were identified by morphology, growth and biochemical characteristics, susceptibility to a panel of anti-microbial agents in disc diffusion assay and molecular characterization by PCR using glt A and gyr B genes. Results: 94% of Acinetobacter spp were detected as multi drug resistant (MDR) and sensitive to Polymixin B only. About 6% Acinetobacter spp were also MDR but sensitive to Polymixin B, Meropenem and Salbactum + Cefoperazone. All tested isolates exhibited differing resistance representation, as establish by medium incorporation – replica method, against different tested antibiotics, as follows: Amoxicillin – Cal-vulanic acid, Tazobactam, Ceftriaxone, Ceftazidime, Meropenem, Imipenem, Gentamicin, Amikacin, Chlo-ramphenicol, Cotrimoxazole, Tobramycin, Salbactam, Cefoperazone, Gentamicin and Amikacin. All the isolates of Acinetobacter baumannii were PCR positive for glt A and gyr B. Conclusions: Acinetobacter baumannii is the most frequently isolated and alarming pathogen in the health care system specifically for the patients in intensive care units (ICUs). Its survival in hospital environment is because of tolerance the antibiotics and antiseptic pressures. Multi drug resistance made this pathogen the lethal pathogen of this century to infect debilitated patients. There is a strict need to monitor the surveillance of global clones at institutional and or intra-institutional level for accurate treatment, precise prevention and batter control.

View Article
February 2016
1 Read

A fast click-slow release strategy towards the HPLC-free synthesis of RNA.

Chem Commun (Camb) 2016 Jan;52(7):1405-8

Department of Chemistry, SUNY, University at Albany, 1400 Washington Avenue, Albany, NY 1222, USA.

View Article
January 2016
6 Reads
3 PubMed Central Citations(source)
6.830 Impact Factor

Modulation of hepatitis C virus genome replication by glycosphingolipids and four-phosphate adaptor protein 2.

J Virol 2014 Nov 13;88(21):12276-95. Epub 2014 Aug 13.

Center for Immunology and Microbial Disease, Albany Medical College, Albany, New York, USA

View Article
November 2014
8 Reads
19 PubMed Central Citations(source)
4.440 Impact Factor

Use of the SYBR Green dye for measuring helicase activity.

Enzyme Microb Technol 2013 Mar 4;52(3):196-8. Epub 2013 Jan 4.

Department of Biological and Biomedical Sciences, The Aga Khan University, Karachi, Pakistan.

View Article
March 2013
4 Reads
2 PubMed Central Citations(source)
2.320 Impact Factor

Fluoroquinolones inhibit HCV by targeting its helicase.

Antivir Ther 2012 25;17(3):467-76. Epub 2011 Oct 25.

Department of Biological and Biomedical Sciences, Aga Khan University, Karachi, Pakistan.

View Article
August 2012
7 Reads
3 PubMed Central Citations(source)
3.020 Impact Factor

Safe blood transfusion practices in blood banks of Karachi, Pakistan.

Transfus Med 2011 Feb 5;21(1):57-62. Epub 2010 Oct 5.

Department of Biological and Biomedical Sciences, Aga Khan University, Karachi, Pakistan.

View Article
February 2011
4 PubMed Central Citations(source)
1.310 Impact Factor

A theoretical study of the stability of DNA binding with cis/trans platin.

Indian J Biochem Biophys 2004 Dec;41(6):305-10

Physics Department, Integral University, Kursi Road, Lucknow 226 026, India.

View Article
December 2004
0.870 Impact Factor

Top co-authors

Sammer Siddiqui
Sammer Siddiqui

The Aga Khan University

2
Maksim Royzen
Maksim Royzen

New York University

2
Mehmet V Yigit
Mehmet V Yigit

Harvard Medical School

2
Sadiq Rehmani
Sadiq Rehmani

Mount Sinai St. Luke's Hospital

1
Shahana U Kazmi
Shahana U Kazmi

University of Karachi

1
Syed Ali
Syed Ali

Aga Khan University Hospital

1
Shamshad Zarina
Shamshad Zarina

University of Karachi

1
Syed H Ali
Syed H Ali

Aga Khan University

1
Jason M MacKenzie
Jason M MacKenzie

University of Melbourne

1
Kouacou V Konan
Kouacou V Konan

University Park

1