Publications by authors named "Irfan A Asangani"

39Publications

Cell Cycle Checkpoints Cooperate to Suppress DNA- and RNA-Associated Molecular Pattern Recognition and Anti-Tumor Immune Responses.

Cell Rep 2020 Sep;32(9):108080

Department of Cancer Biology, Penn Center for Genome Integrity, Basser Center for BRCA, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2020.108080DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7530826PMC
September 2020

Tumor-Derived Retinoic Acid Regulates Intratumoral Monocyte Differentiation to Promote Immune Suppression.

Cell 2020 03 12;180(6):1098-1114.e16. Epub 2020 Mar 12.

Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19014, USA; Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2020.02.042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7194250PMC
March 2020

Epigenetic Regulation of Chromatin in Prostate Cancer.

Adv Exp Med Biol 2019 ;1210:379-407

Department of Cancer Biology, Abramson Family Cancer Research Institute, Epigenetics Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

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http://dx.doi.org/10.1007/978-3-030-32656-2_17DOI Listing
February 2020

EWS/ETS-Driven Ewing Sarcoma Requires BET Bromodomain Proteins.

Cancer Res 2018 08 13;78(16):4760-4773. Epub 2018 Jun 13.

Department of Cancer Biology, Perelman School of Medicine, University of Pennsylvania, BRBII/III, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1158/0008-5472.CAN-18-0484DOI Listing
August 2018

Resistance to BET Inhibitor Leads to Alternative Therapeutic Vulnerabilities in Castration-Resistant Prostate Cancer.

Cell Rep 2018 02;22(9):2236-2245

Department of Cancer Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Department of Cancer Biology, Abramson Family Cancer Research Institute, Epigenetics Institute, Perelman School of Medicine, University of Pennsylvania, 421 Curie Boulevard, BRBII/III, Philadelphia, PA 19104, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2018.02.011DOI Listing
February 2018

The depalmitoylase APT1 directs the asymmetric partitioning of Notch and Wnt signaling during cell division.

Sci Signal 2018 01 2;11(511). Epub 2018 Jan 2.

Department of Cancer Biology, University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1126/scisignal.aam8705DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5914505PMC
January 2018

Development of Peptidomimetic Inhibitors of the ERG Gene Fusion Product in Prostate Cancer.

Cancer Cell 2017 04 23;31(4):532-548.e7. Epub 2017 Mar 23.

Michigan Center for Translational Pathology, University of Michigan, 1400 East Medical Center Drive, 5316 CCGC, Ann Arbor, MI 48109, USA; Department of Pathology, University of Michigan, 1400 East Medical Center Drive, 5316 CCGC, Ann Arbor, MI 48109, USA; Howard Hughes Medical Institute, University of Michigan, 1400 East Medical Center Drive, 5316 CCGC, Ann Arbor, MI 48109, USA; Department of Urology, University of Michigan, 1400 East Medical Center Drive, 5316 CCGC, Ann Arbor, MI 48109, USA; Comprehensive Cancer Center, University of Michigan, 1400 East Medical Center Drive, 5316 CCGC, Ann Arbor, MI 48109, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2017.02.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5443258PMC
April 2017

BET Bromodomain Inhibitors Enhance Efficacy and Disrupt Resistance to AR Antagonists in the Treatment of Prostate Cancer.

Mol Cancer Res 2016 04 20;14(4):324-31. Epub 2016 Jan 20.

Michigan Center for Translational Pathology, University of Michigan, Ann Arbor, Michigan. Department of Pathology, University of Michigan, Ann Arbor, Michigan. Comprehensive Cancer Center, University of Michigan, Ann Arbor, Michigan. Howard Hughes Medical Institute, University of Michigan, Ann Arbor, Michigan. Department of Urology, University of Michigan, Ann Arbor, Michigan.

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http://dx.doi.org/10.1158/1541-7786.MCR-15-0472DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4834259PMC
April 2016

Galanin modulates the neural niche to favour perineural invasion in head and neck cancer.

Nat Commun 2015 Apr 28;6:6885. Epub 2015 Apr 28.

1] Department of Periodontics and Oral Medicine, University of Michigan School of Dentistry, Ann Arbor, Michigan 48109, USA [2] Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA [3] Michigan Center for Translational Pathology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA.

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http://dx.doi.org/10.1038/ncomms7885DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4476386PMC
April 2015

Targeting the MLL complex in castration-resistant prostate cancer.

Nat Med 2015 Apr 30;21(4):344-52. Epub 2015 Mar 30.

1] Michigan Center for Translational Pathology, University of Michigan, Ann Arbor, Michigan, USA. [2] Department of Pathology, University of Michigan, Ann Arbor, Michigan, USA. [3] Comprehensive Cancer Center, University of Michigan, Ann Arbor, Michigan, USA. [4] Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan, USA. [5] Howard Hughes Medical Institute, University of Michigan, Ann Arbor, Michigan, USA. [6] Department of Urology, University of Michigan, Ann Arbor, Michigan, USA.

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http://www.pcf.org/atf/cf/%7B7c77d6a2-5859-4d60-af47-132fd0f
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http://www.nature.com/doifinder/10.1038/nm.3830
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http://dx.doi.org/10.1038/nm.3830DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4390530PMC
April 2015

The lncRNA PCAT29 inhibits oncogenic phenotypes in prostate cancer.

Mol Cancer Res 2014 Aug 16;12(8):1081-7. Epub 2014 Jul 16.

Michigan Center for Translational Pathology, University of Michigan, Ann Arbor, Michigan. Department of Pathology, University of Michigan, Ann Arbor, Michigan. Comprehensive Cancer Center, University of Michigan, Ann Arbor, Michigan. Howard Hughes Medical Institute, University of Michigan, Ann Arbor, Michigan.

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http://dx.doi.org/10.1158/1541-7786.MCR-14-0257DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4135019PMC
August 2014

BETs abet Tam-R in ER-positive breast cancer.

Cell Res 2014 Aug 8;24(8):899-900. Epub 2014 Jul 8.

1] Michigan Center for Translational Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA [2] Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA [3] Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA [4] Department of Urology, University of Michigan Medical School, Ann Arbor, MI 48109, USA [5] Howard Hughes Medical Institute, University of Michigan Medical School, Ann Arbor, MI 48109, USA.

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http://dx.doi.org/10.1038/cr.2014.90DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4123300PMC
August 2014

BETting on a new prostate cancer treatment.

Cell Cycle 2014 6;13(13):2015-6. Epub 2014 Jun 6.

Michigan Center for Translational Pathology; University of Michigan Medical School; Ann Arbor, MI USA; Department of Pathology; University of Michigan Medical School; Ann Arbor, MI USA; Howard Hughes Medical Institute; University of Michigan Medical School; Ann Arbor, MI USA; Comprehensive Cancer Center; University of Michigan Medical School; Ann Arbor, MI USA; Department of Urology; University of Michigan Medical School; Ann Arbor, MI USA.

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http://dx.doi.org/10.4161/cc.29459DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4111688PMC
January 2015

Therapeutic targeting of BET bromodomain proteins in castration-resistant prostate cancer.

Nature 2014 Jun 23;510(7504):278-82. Epub 2014 Apr 23.

1] Michigan Center for Translational Pathology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA [2] Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA [3] Howard Hughes Medical Institute, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA [4] Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA [5] Department of Urology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA.

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http://dx.doi.org/10.1038/nature13229DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4075966PMC
June 2014

Curcumin regulates miR-21 expression and inhibits invasion and metastasis in colorectal cancer.

Biosci Rep 2011 Jun;31(3):185-97

Department of Experimental Surgery, Mannheim Medical Faculty, Ruprecht-Karls-University Heidelberg, 68167 Mannheim, Germany.

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http://bioscirep.org/cgi/doi/10.1042/BSR20100065
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http://dx.doi.org/10.1042/BSR20100065DOI Listing
June 2011

Cetuximab attenuates metastasis and u-PAR expression in non-small cell lung cancer: u-PAR and E-cadherin are novel biomarkers of cetuximab sensitivity.

Cancer Res 2009 Mar 10;69(6):2461-70. Epub 2009 Mar 10.

Department of Experimental Surgery and Molecular Oncology of Solid Tumors, Medical Faculty Mannheim, University Heidelberg and DKFZ (German Cancer Research Center), Heidelberg, Germany.

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http://dx.doi.org/10.1158/0008-5472.CAN-08-3236DOI Listing
March 2009

NRF-1, and AP-1 regulate the promoter of the human calpain small subunit 1 (CAPNS1) gene.

Gene 2008 Feb 23;410(1):197-206. Epub 2007 Dec 23.

Department Experimental Surgery Mannheim, University Heidelberg, and Molecular Oncology of Solid Tumors Unit, German Cancer Research Center (DKFZ) Heidelberg, Germany.

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http://dx.doi.org/10.1016/j.gene.2007.12.009DOI Listing
February 2008

Combination analysis of activator protein-1 family members, Sp1 and an activator protein-2alpha-related factor binding to different regions of the urokinase receptor gene in resected colorectal cancers.

Clin Cancer Res 2005 Dec;11(24 Pt 1):8538-48

Department of Experimental Surgery and Molecular Oncology, Universitaetsklinikum Mannheim and Department of Pediatrics, Dr. v. Haunersches Kinderspital, Munich, Germany.

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http://dx.doi.org/10.1158/1078-0432.CCR-05-0786DOI Listing
December 2005