Dr Ireneusz T Padol, PhD - McMaster University - Emeritus

Dr Ireneusz T Padol

PhD

McMaster University

Emeritus

Hamiton / Dundas, Ontario | Canada

Main Specialties: Allergy & Immunology, Clinical & Laboratory Immunology, Gastroenterology, Medical Microbiology, Other, Pharmacology, Rheumatology

Additional Specialties: Medical Biology, Pharmacology, Immunology, Gastroenterology


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Dr Ireneusz T Padol, PhD - McMaster University - Emeritus

Dr Ireneusz T Padol

PhD

Introduction

June 2011-Present, Emeritus and Member of Quarter Century Club at McMaster
University, Hamilton, Ontario, Canada

June 1985-June 2011, McMaster University, Hamilton, Ontario
Research Associate-Coordinatorl/Laboratory Manager (2000-present) and Research Assistant (1990-1999), Department of Medicine at McMaster University

Member of The Farncombe Family Digestive Health Research Institute formerly known as the Intestinal Diseases Research Program (IDRP) and Intestinal Diseases Research Unit (IDRU), Department of Medicine, Faculty of Health Sciences

Areas of interest: inflammation and anti-inflammatory drugs, physiology of gastric acid secretion, Helicobacter pylori infection.
Expertise in immunology, immunomodulation, microbiology, gastric physiology, gastrointestinal diseases, pharmacology, drug development and testing.

? Managing a laboratory dedicated to basic research in the area of inflammation and cardiovascular and gastrointestinal risks associated with current treatments, gastrointestinal inflammation, immunomodulation, gastric physiology and mucosal immunology.
? Responsible for design, planning, and management of multiple research projects in the area of gastrointestinal inflammation and physiology e.g.: novel antisecretory drugs, anti-inflammatory drugs, High Throughput Screening (HTS) for novel non-antibiotic antibacterial compounds, radiobiology, radiolabeling and use of radiolabeled compounds, design of ELISAs and radoimmunoassays, continuous use of spectrophotometers, liquid scintillation counters and gamma counters.
? Writing grant proposals, publications and reports, peer-reviewing manuscripts.
? Coordinating and facilitating collaborations with other investigators, medical and pharmaceutical research centres.
? Consulting and providing scientific expertise in patent disputes.
? Recruitment, training and supervision of staff, post-doctoral fellows and students.
? Advanced computer skills related to hardware and software.
? Administrative duties, negotiations, budgeting and financial responsibilities.

Research Assistant (1985-1990), Department of Pathology/Intestinal Diseases Research Unit at McMaster University, Hamilton, Ontario.

Research interest in the area of psychoneuroimmunology. Expertise in immunological methodology and animal research work.

? The role of neurotransmitters in modulating immune response, systemically and in the gastrointestinal tract.
? Co-inventor of micro-encapsulation apparatus for growing of immuno-competent and other cells secreting biologically active compounds trapped in semipermable capsules.
? Training and supervision of laboratory staff and students.
? Managerial responsibilities in Intestinal Diseases Research Unit/Program.

Primary Affiliation: McMaster University - Hamiton / Dundas, Ontario , Canada

Specialties:

Additional Specialties:


View Dr Ireneusz T Padol’s Resume / CV

Education

Jun 1995
McMaster University, Department of Medicine, Hamilton, Ontario, Canada.
Post-doctoral training
Supervisor: Professor Richard H. Hunt
Mar 1992
Medical University of Lodz, Poland.
Doctor of Medicine in the field of Medical Biology (PhD),
Mar 1980
Jagiellonian University Krakow Poland
MSc Biology
With Honours

Experience

Jun 2010
Member of Quarter Century Club at McMaster University
May 2009
Poster of Distinction Award at Digestive Disease Week Chicago, IL
Presenter
Sep 2008
Award of Invention “Probiotics as Modulators of Gastric Acid Secretion”
Inventor
http://milo.mcmaster.ca/technologies/available/10-028
May 2002
Poster of Distinction Award at Digestive Disease Week 2002 San Francisco, CA
Presenter
May 2002
Best Poster Prize from Intestinal Disease Research Program, McMaster University, Canada
Presenter
May 2001
Poster of Distinction Award at Digestive Disease Week 2001, Atlanta, GA
Presenter

Publications

17Publications

83Reads

33Profile Views

63PubMed Central Citations

Effect of Aspirin and ibuprofen either alone or in combination on gastric mucosa and bleeding time and on serum prostaglandin E and thromboxane A levels in the anaesthetized rats in vivo.

Mol Cell Biochem 2018 Jan 1;438(1-2):25-34. Epub 2017 Aug 1.

Division of Gastroenterology, McMaster University, Hamilton, ON, Canada.

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http://dx.doi.org/10.1007/s11010-017-3110-1DOI Listing
January 2018
18 Reads
2.393 Impact Factor

Altered physiology of acid secretion in depression-prone Flinders rats results in exacerbated NSAID and stress-induced gastric damage.

Neurogastroenterol Motil 2012 Feb 14;24(2):154-63, e89. Epub 2011 Nov 14.

Farncombe Family Digestive Health Research Institute, Division of Gastroenterology, Department of Medicine, McMaster University, Hamilton, Ontario, Canada.

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http://dx.doi.org/10.1111/j.1365-2982.2011.01811.xDOI Listing
February 2012
3.587 Impact Factor

Spontaneous autoimmune gastritis and hypochlorhydria are manifest in the ileitis-prone SAMP1/YitFcs mice.

Am J Physiol Gastrointest Liver Physiol 2012 Jan 15;302(1):G105-15. Epub 2011 Sep 15.

Department of Medicine, University of Virginia, Charlottesville, Virginia, USA.

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http://dx.doi.org/10.1152/ajpgi.00194.2011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3345967PMC
January 2012
2 Reads
3.798 Impact Factor

Association of myocardial infarctions with COX-2 inhibition may be related to immunomodulation towards a Th1 response resulting in atheromatous plaque instability: an evidence-based interpretation.

Rheumatology (Oxford) 2010 May 24;49(5):837-43. Epub 2009 Sep 24.

Department of Medicine, Division of Gastroenterology, Farncombe Family Digestive Health Research Institute, McMaster University Health Science Centre, Hamilton, Ontario, Canada.

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http://dx.doi.org/10.1093/rheumatology/kep225DOI Listing
May 2010
19 Reads
3 Citations
4.475 Impact Factor

Clinical impact of CYP2C19 polymorphism on the action of proton pump inhibitors: a review of a special problem.

Int J Clin Pharmacol Ther 2007 Mar;45(3):188; author reply 189-90

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http://dx.doi.org/10.5414/cpp45188DOI Listing
March 2007
1.044 Impact Factor

The effect of CYP2C19 polymorphisms on H. pylori eradication rate in dual and triple first-line PPI therapies: a meta-analysis.

Am J Gastroenterol 2006 Jul;101(7):1467-75

Division of Gastroenterology, McMaster University, Hamilton, Ontario, Canada.

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http://dx.doi.org/10.1111/j.1572-0241.2006.00717.xDOI Listing
July 2006
13 Reads
32 Citations
10.760 Impact Factor

Peptic ulcer disease today.

Nat Clin Pract Gastroenterol Hepatol 2006 Feb;3(2):80-9

McMaster University, Health Science Centre, Hamilton, ON, Canada.

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http://dx.doi.org/10.1038/ncpgasthep0393DOI Listing
February 2006
25 Reads
28 Citations

Host-specific differences in the physiology of acid secretion related to prostaglandins may play a role in gastric inflammation and injury.

Am J Physiol Gastrointest Liver Physiol 2005 Jun 27;288(6):G1110-7. Epub 2005 Jan 27.

Div. of Gastroenterology, McMaster Univ., Health Sciences Centre, Rm. 4W8A, 1200 Main St. West, Hamilton, ON, Canada L8N 3Z5.

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http://dx.doi.org/10.1152/ajpgi.00364.2004DOI Listing
June 2005
4 Reads
3.800 Impact Factor

Effect of Th1 cytokines on acid secretion in pharmacologically characterised mouse gastric glands.

Authors:
I T Padol R H Hunt

Gut 2004 Aug;53(8):1075-81

Intestinal Disease Research Programme, McMaster University, Hamilton, Ontario, Canada.

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http://dx.doi.org/10.1136/gut.2003.026435DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1774136PMC
August 2004
14.660 Impact Factor

Establishment of T-Helper-2 immune response based gerbil model of enteric infection.

Scand J Gastroenterol 2004 Jul;39(7):668-73

Intestinal Disease Research Programme, McMaster University, Hamilton, Ontario, Canada.

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http://dx.doi.org/10.1080/00365520410005315DOI Listing
July 2004
2.329 Impact Factor

Effect of purified lipopolysaccharides from strains of Helicobacter pylori and Helicobacter felis on acid secretion in mouse gastric glands in vitro.

Infect Immun 2001 Jun;69(6):3891-6

Intestinal Disease Research Programme, McMaster University, Hamilton, Ontario, Canada.

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http://dx.doi.org/10.1128/IAI.69.6.3891-3896.2001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC98418PMC
June 2001
3.731 Impact Factor

Therapeutic effects of the endothelin receptor antagonist Ro 48-5695 in the TNBS/DNBS rat model of colitis.

Eur J Gastroenterol Hepatol 2000 Mar;12(3):257-65

Intestinal Disease Research Programme, McMaster University, Hamilton, Ontario, Canada.

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http://dx.doi.org/10.1097/00042737-200012030-00001DOI Listing
March 2000
2.152 Impact Factor

Anti-ulcerogenic properties of endothelin receptor antagonists in the rat.

Aliment Pharmacol Ther 1999 Apr;13(4):537-44

Intestinal Disease Research Programme, McMaster University, Hamilton, Ontario, Canada.

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http://dx.doi.org/10.1046/j.1365-2036.1999.00503.xDOI Listing
April 1999
2 Reads
5.727 Impact Factor

Inhibitory effect of diazepam on human natural killer activity in vitro.

Cytobios 1994 ;77(310):131-6

Institute of Endocrinology, Medical University of Lódź, Poland.

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July 1994

Immunomodulatory properties of diazepam-binding inhibitor: effect on human interleukin-6 secretion, lymphocyte proliferation and natural killer cell activity in vitro.

Neuropeptides 1993 Sep;25(3):207-11

Institute of Endocrinology, Medical University of Lódź, Poland.

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http://dx.doi.org/10.1016/0143-4179(93)90104-iDOI Listing
September 1993
2.546 Impact Factor

Immunomodulatory activities of the somatostatin analogue BIM 23014c: effects on murine lymphocyte proliferation and natural killer activity.

Regul Pept 1991 Feb;32(2):129-39

Department of Pathology, McMaster University, Hamilton, Canada.

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http://dx.doi.org/10.1016/0167-0115(91)90041-eDOI Listing
February 1991
2.014 Impact Factor

Selective modulation of the natural killer activity of murine intestinal intraepithelial leucocytes by the neuropeptide substance P.

Immunology 1990 Oct;71(2):196-201

Department of Pathology, McMaster University, Hamilton, Ontario, Canada.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1384303PMC
October 1990
3.795 Impact Factor