Irene T Weber

Irene T Weber

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Irene T Weber

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Highly drug-resistant HIV-1 protease reveals decreased intra-subunit interactions due to clusters of mutations.

FEBS J 2020 Jan 9. Epub 2020 Jan 9.

Department of Biology, Georgia State University, Atlanta, GA, USA.

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http://dx.doi.org/10.1111/febs.15207DOI Listing
January 2020

Potent antiviral HIV-1 protease inhibitor combats highly drug resistant mutant PR20.

Biochem Biophys Res Commun 2019 Oct 29;519(1):61-66. Epub 2019 Aug 29.

Department of Biology, Georgia State University, Atlanta, GA, 30303, USA; Department of Chemistry, Georgia State University, Atlanta, GA, 30303, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bbrc.2019.08.126DOI Listing
October 2019

Structural studies of antiviral inhibitor with HIV-1 protease bearing drug resistant substitutions of V32I, I47V and V82I.

Biochem Biophys Res Commun 2019 Jun 12;514(3):974-978. Epub 2019 May 12.

Department of Biology, Georgia State University, Atlanta, GA, 30303, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bbrc.2019.05.064DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6601333PMC
June 2019

Highly Drug-Resistant HIV-1 Protease Mutant PRS17 Shows Enhanced Binding to Substrate Analogues.

ACS Omega 2019 May 17;4(5):8707-8719. Epub 2019 May 17.

Department of Biology, Georgia State University, P.O. Box 4010, Atlanta, Georgia 30302, United States.

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http://dx.doi.org/10.1021/acsomega.9b00683DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6545544PMC
May 2019

Steric hindrance controls pyridine nucleotide specificity of a flavin-dependent NADH:quinone oxidoreductase.

Protein Sci 2019 01 31;28(1):167-175. Epub 2018 Oct 31.

Department of Chemistry, Georgia State University, Atlanta, Georgia, 30302-3965.

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http://dx.doi.org/10.1002/pro.3514DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6295900PMC
January 2019

Design, synthesis, and X-ray studies of potent HIV-1 protease inhibitors incorporating aminothiochromane and aminotetrahydronaphthalene carboxamide derivatives as the P2 ligands.

Eur J Med Chem 2018 Dec 18;160:171-182. Epub 2018 Sep 18.

Department of Refractory Viral Infections, National Center for Global Health & Medicine Research Institute, Tokyo, 162-8655, Japan; Departments of Hematology and Infectious Diseases, Kumamoto University Graduate School of Medical and Pharmaceutical Sciences, Kumamoto, 860-8556, Japan; Experimental Retrovirology Section, HIV and AIDS Malignancy Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, United States.

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https://linkinghub.elsevier.com/retrieve/pii/S02235234183081
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http://dx.doi.org/10.1016/j.ejmech.2018.09.046DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6237192PMC
December 2018

Analysis of drug resistance in HIV protease.

BMC Bioinformatics 2018 Oct 22;19(Suppl 11):362. Epub 2018 Oct 22.

Department of Computer Science, 25 Park Place, Atlanta, GA 30303, USA.

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https://bmcbioinformatics.biomedcentral.com/articles/10.1186
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http://dx.doi.org/10.1186/s12859-018-2331-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6196403PMC
October 2018

Drug Resistance Mutation L76V Alters Nonpolar Interactions at the Flap-Core Interface of HIV-1 Protease.

ACS Omega 2018 Sep 27;3(9):12132-12140. Epub 2018 Sep 27.

Department of Biology, Molecular Basis of Disease Program, Department of Computer Science, and Department of Chemistry, Georgia State University, Atlanta, Georgia 30303, United States.

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http://dx.doi.org/10.1021/acsomega.8b01683DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6167001PMC
September 2018

Tackling the problem of HIV drug resistance.

Postepy Biochem 2016;62(3):273-279

Department of Computer Science, Georgia State University, Atlanta, GA, USA.

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December 2017

Design, Synthesis, Biological Evaluation, and X-ray Studies of HIV-1 Protease Inhibitors with Modified P2' Ligands of Darunavir.

ChemMedChem 2017 12 24;12(23):1942-1952. Epub 2017 Nov 24.

Departments of Hematology and Infectious Diseases, Kumamoto University School of Medicine, Kumamoto, 860-8556, Japan.

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http://dx.doi.org/10.1002/cmdc.201700614DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5896574PMC
December 2017

Design, synthesis, X-ray studies, and biological evaluation of novel macrocyclic HIV-1 protease inhibitors involving the P1'-P2' ligands.

Bioorg Med Chem Lett 2017 11 6;27(21):4925-4931. Epub 2017 Sep 6.

Departments of Hematology and Infectious Diseases, Kumamoto University of Medicine, Kumamoto 860-8556, Japan; Experimental Retrovirology Section, HIV and AIDS Malignancy Branch National Cancer Institute, Bethesda, MD 20892, USA; Center for Clinical Sciences, National Center for Global Health and Medicine, Shinjuku, Tokyo 162-8655, Japan.

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http://dx.doi.org/10.1016/j.bmcl.2017.09.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5647257PMC
November 2017

Design of novel HIV-1 protease inhibitors incorporating isophthalamide-derived P2-P3 ligands: Synthesis, biological evaluation and X-ray structural studies of inhibitor-HIV-1 protease complex.

Bioorg Med Chem 2017 10 9;25(19):5114-5127. Epub 2017 Apr 9.

Department of Hematology, Kumamoto University of Medicine, Kumamoto 860-8556, Japan; Department of Infectious Diseases, Kumamoto University of Medicine, Kumamoto 860-8556, Japan; Experimental Retrovirology Section, HIV and AIDS Malignancy Branch National Cancer Institute, Bethesda, MD 20892, USA; Department of Refractory Viral Infection, National Center for Global Health and Medicine Research Institute, Shinjuku, Tokyo 162-8655, Japan.

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https://linkinghub.elsevier.com/retrieve/pii/S09680896173073
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http://dx.doi.org/10.1016/j.bmc.2017.04.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5617771PMC
October 2017

Decoding HIV resistance: from genotype to therapy.

Future Med Chem 2017 09 9;9(13):1529-1538. Epub 2017 Aug 9.

Department of Computer Science, Georgia State University, Atlanta, GA 30303, USA.

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http://dx.doi.org/10.4155/fmc-2017-0048DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5694023PMC
September 2017

Room Temperature Neutron Crystallography of Drug Resistant HIV-1 Protease Uncovers Limitations of X-ray Structural Analysis at 100 K.

J Med Chem 2017 03 28;60(5):2018-2025. Epub 2017 Feb 28.

Biology and Soft Matter Division, Oak Ridge National Laboratory , Oak Ridge, Tennessee 37831, United States.

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http://dx.doi.org/10.1021/acs.jmedchem.6b01767DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5644340PMC
March 2017

Can we design drugs for HIV/AIDS that are less susceptible to resistance?

Authors:
Irene T Weber

Future Med Chem 2015 30;7(17):2301-4. Epub 2015 Nov 30.

Department of Biology, Georgia State University, PO Box 4010, Atlanta, GA 30302-4010, USA.

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http://dx.doi.org/10.4155/fmc.15.149DOI Listing
September 2016

In vitro heme biotransformation by the HupZ enzyme from Group A streptococcus.

Biometals 2016 08 6;29(4):593-609. Epub 2016 May 6.

Department of Biology, College of Arts and Sciences, Georgia State University, P.O. Box 4010, Atlanta, GA, 30302-4010, USA.

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http://dx.doi.org/10.1007/s10534-016-9937-1DOI Listing
August 2016

Automated prediction of HIV drug resistance from genotype data.

BMC Bioinformatics 2016 Aug 31;17 Suppl 8:278. Epub 2016 Aug 31.

Department of Biology, Georgia State University, Atlanta, GA, 30303, USA.

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http://dx.doi.org/10.1186/s12859-016-1114-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5009519PMC
August 2016

Highly resistant HIV-1 proteases and strategies for their inhibition.

Future Med Chem 2015 ;7(8):1023-38

Department of Biology, Georgia State University, PO Box 4010, Atlanta, GA 30302-4010, USA.

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http://dx.doi.org/10.4155/fmc.15.44DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4521605PMC
April 2016

Binding of Clinical Inhibitors to a Model Precursor of a Rationally Selected Multidrug Resistant HIV-1 Protease Is Significantly Weaker Than That to the Released Mature Enzyme.

Biochemistry 2016 04 15;55(16):2390-400. Epub 2016 Apr 15.

Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Department of Health and Human Services , Bethesda, Maryland 20892, United States.

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http://dx.doi.org/10.1021/acs.biochem.6b00012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5013724PMC
April 2016

Structure-based design, synthesis, X-ray studies, and biological evaluation of novel HIV-1 protease inhibitors containing isophthalamide-derived P2-ligands.

Bioorg Med Chem Lett 2015 Nov 30;25(21):4903-4909. Epub 2015 May 30.

Departments of Hematology and Infectious Diseases, Kumamoto University of Medicine, Kumamoto 860-8556, Japan; Experimental Retrovirology Section, HIV and AIDS Malignancy Branch, National Cancer Institute, Bethesda, MD 20892, USA; Center for Clinical Sciences, National Center for Global Health and Medicine, Shinjuku, Tokyo 162-8655, Japan.

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http://dx.doi.org/10.1016/j.bmcl.2015.05.052DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4607586PMC
November 2015

Conformational variation of an extreme drug resistant mutant of HIV protease.

J Mol Graph Model 2015 Nov 8;62:87-96. Epub 2015 Sep 8.

Department of Biology, Georgia State University, Atlanta, GA 30303, USA; Department of Chemistry, Georgia State University, Atlanta, GA 30303, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jmgm.2015.09.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4695280PMC
November 2015

Structure-based design of potent HIV-1 protease inhibitors with modified P1-biphenyl ligands: synthesis, biological evaluation, and enzyme-inhibitor X-ray structural studies.

J Med Chem 2015 Jul 24;58(13):5334-43. Epub 2015 Jun 24.

§Departments of Hematology and Infectious Diseases, Kumamoto University Graduate School of Medical and Pharmaceutical Sciences, Kumamoto 860-8556, Japan.

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http://dx.doi.org/10.1021/acs.jmedchem.5b00676DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4765733PMC
July 2015

Substituted Bis-THF Protease Inhibitors with Improved Potency against Highly Resistant Mature HIV-1 Protease PR20.

J Med Chem 2015 Jun 4;58(12):5088-95. Epub 2015 Jun 4.

†Department of Biology, Molecular Basis of Disease Program, Georgia State University, Atlanta, Georgia 30303, United States.

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http://pubs.acs.org/doi/10.1021/acs.jmedchem.5b00474
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http://dx.doi.org/10.1021/acs.jmedchem.5b00474DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4522690PMC
June 2015

The combined structural and kinetic characterization of a bacterial nitronate monooxygenase from Pseudomonas aeruginosa PAO1 establishes NMO class I and II.

J Biol Chem 2014 Aug 7;289(34):23764-75. Epub 2014 Jul 7.

From the Departments of Chemistry, Biology, Center for Biotechnology and Drug Design, Center for Diagnostics and Therapeutics, Georgia State University, Atlanta, Georgia 30302,

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http://dx.doi.org/10.1074/jbc.M114.577791DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4156069PMC
August 2014

Structures of darunavir-resistant HIV-1 protease mutant reveal atypical binding of darunavir to wide open flaps.

ACS Chem Biol 2014 Jun 28;9(6):1351-8. Epub 2014 Apr 28.

Department of Chemistry, ‡Department of Biology, and §Department of Computer Science, Georgia State University , Atlanta, Georgia 30303, United States.

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http://dx.doi.org/10.1021/cb4008875DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4076034PMC
June 2014

Novel complex MAD phasing and RNase H structural insights using selenium oligonucleotides.

Acta Crystallogr D Biol Crystallogr 2014 Feb 29;70(Pt 2):354-61. Epub 2014 Jan 29.

Department of Chemistry and Department of Biology, Georgia State University, Atlanta, GA 30303, USA.

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http://dx.doi.org/10.1107/S1399004713027922DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3940196PMC
February 2014

Structure of choline oxidase in complex with the reaction product glycine betaine.

Acta Crystallogr D Biol Crystallogr 2014 Feb 29;70(Pt 2):405-13. Epub 2014 Jan 29.

Department of Chemistry, Georgia State University, PO Box 3965, Atlanta, GA 30302-3965, USA.

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http://dx.doi.org/10.1107/S1399004713029283DOI Listing
February 2014

Structural basis for a hand-like site in the calcium sensor CatchER with fast kinetics.

Acta Crystallogr D Biol Crystallogr 2013 Dec 19;69(Pt 12):2309-19. Epub 2013 Nov 19.

Department of Chemistry, Georgia State University, Atlanta, GA 30303, USA.

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http://dx.doi.org/10.1107/S0907444913021306DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3852649PMC
December 2013

Highly potent HIV-1 protease inhibitors with novel tricyclic P2 ligands: design, synthesis, and protein-ligand X-ray studies.

J Med Chem 2013 Sep 15;56(17):6792-802. Epub 2013 Aug 15.

Department of Chemistry and Department of Medicinal Chemistry, Purdue University , West Lafayette, Indiana 47907, United States.

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http://dx.doi.org/10.1021/jm400768fDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3800042PMC
September 2013

Joint X-ray/neutron crystallographic study of HIV-1 protease with clinical inhibitor amprenavir: insights for drug design.

J Med Chem 2013 Jul 28;56(13):5631-5. Epub 2013 Jun 28.

Departments of Chemistry and Biology, Georgia State University , Atlanta, Georgia, United States.

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http://dx.doi.org/10.1021/jm400684fDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3815997PMC
July 2013

Sparse Representation for Prediction of HIV-1 Protease Drug Resistance.

Proc SIAM Int Conf Data Min 2013 ;2013:342-349

Department of Computer Science, Georgia State University.

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http://dx.doi.org/10.1137/1.9781611972832.38DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4045614PMC
January 2013

Reaction intermediates discovered in crystal structures of enzymes.

Adv Protein Chem Struct Biol 2012 ;87:57-86

Department of Biology, Georgia State University, Atlanta, Georgia, USA.

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http://dx.doi.org/10.1016/B978-0-12-398312-1.00003-2DOI Listing
November 2012

Capturing the reaction pathway in near-atomic-resolution crystal structures of HIV-1 protease.

Biochemistry 2012 Oct 21;51(39):7726-32. Epub 2012 Sep 21.

Department of Biology, Molecular Basis of Disease Program, Georgia State University, Atlanta, Georgia 30303, United States.

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http://pubs.acs.org/doi/10.1021/bi3008092
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http://dx.doi.org/10.1021/bi3008092DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3476052PMC
October 2012

Potent antiviral HIV-1 protease inhibitor GRL-02031 adapts to the structures of drug resistant mutants with its P1'-pyrrolidinone ring.

J Med Chem 2012 Apr 22;55(7):3387-97. Epub 2012 Mar 22.

Department of Biology, Molecular Basis of Disease Program, Georgia State University, P.O. Box 4010, Atlanta, Georgia 30302-4010, USA.

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http://dx.doi.org/10.1021/jm300072dDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3355519PMC
April 2012

HIV-1 protease with 20 mutations exhibits extreme resistance to clinical inhibitors through coordinated structural rearrangements.

Biochemistry 2012 Apr 20;51(13):2819-28. Epub 2012 Mar 20.

Department of Biology, Molecular Basis of Disease Program, Georgia State University, Atlanta, Georgia 30303, United States.

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http://pubs.acs.org/doi/10.1021/bi2018317
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http://dx.doi.org/10.1021/bi2018317DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3328860PMC
April 2012

Critical differences in HIV-1 and HIV-2 protease specificity for clinical inhibitors.

Protein Sci 2012 Mar 24;21(3):339-50. Epub 2012 Jan 24.

Department of Biology, Georgia State University, Atlanta, Georgia 30303, USA.

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http://dx.doi.org/10.1002/pro.2019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3375435PMC
March 2012

Terminal interface conformations modulate dimer stability prior to amino terminal autoprocessing of HIV-1 protease.

Biochemistry 2012 Feb 24;51(5):1041-50. Epub 2012 Jan 24.

Department of Biology, Molecular Basis of Disease Program, Georgia State University, Atlanta, Georgia 30303, United States.

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http://dx.doi.org/10.1021/bi201809sDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3287067PMC
February 2012

Enhancing protein backbone binding--a fruitful concept for combating drug-resistant HIV.

Angew Chem Int Ed Engl 2012 Feb 31;51(8):1778-802. Epub 2012 Jan 31.

Department of Chemistry, Purdue University, West Lafayette, IN 47907, USA.

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http://dx.doi.org/10.1002/anie.201102762DOI Listing
February 2012

Atomic-resolution structure of an N5 flavin adduct in D-arginine dehydrogenase.

Biochemistry 2011 Jul 5;50(29):6292-4. Epub 2011 Jul 5.

Department of Biology, Georgia State University, Atlanta, Georgia 30303, USA.

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http://pubs.acs.org/doi/abs/10.1021/bi200831a
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http://dx.doi.org/10.1021/bi200831aDOI Listing
July 2011

The L76V drug resistance mutation decreases the dimer stability and rate of autoprocessing of HIV-1 protease by reducing internal hydrophobic contacts.

Biochemistry 2011 May 3;50(21):4786-95. Epub 2011 May 3.

Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1021/bi200033zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3101314PMC
May 2011

Inhibition of autoprocessing of natural variants and multidrug resistant mutant precursors of HIV-1 protease by clinical inhibitors.

Proc Natl Acad Sci U S A 2011 May 16;108(22):9072-7. Epub 2011 May 16.

Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, US Department of Health and Human Services, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1073/pnas.1102278108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3107318PMC
May 2011

Autocatalytic maturation, physical/chemical properties, and crystal structure of group N HIV-1 protease: relevance to drug resistance.

Protein Sci 2010 Nov;19(11):2055-72

Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, DHHS, Bethesda, Maryland 20892-0520, USA.

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http://doi.wiley.com/10.1002/pro.486
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http://dx.doi.org/10.1002/pro.486DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3005778PMC
November 2010

Conformational changes and substrate recognition in Pseudomonas aeruginosa D-arginine dehydrogenase.

Biochemistry 2010 Oct 9;49(39):8535-45. Epub 2010 Sep 9.

Department of Biology, Georgia State University,Atlanta, Georgia 30303, USA.

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http://pubs.acs.org/doi/abs/10.1021/bi1005865
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http://dx.doi.org/10.1021/bi1005865DOI Listing
October 2010

Structural and kinetic studies on the Ser101Ala variant of choline oxidase: catalysis by compromise.

Arch Biochem Biophys 2010 Sep 16;501(2):207-13. Epub 2010 Jun 16.

Department of Chemistry, Georgia State University, Atlanta, GA 30302-4098, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S000398611000233
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http://dx.doi.org/10.1016/j.abb.2010.06.014DOI Listing
September 2010

Amprenavir complexes with HIV-1 protease and its drug-resistant mutants altering hydrophobic clusters.

FEBS J 2010 Sep 2;277(18):3699-714. Epub 2010 Aug 2.

Department of Biology, Molecular Basis of Disease Program, Georgia State University, Atlanta, GA, USA.

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http://dx.doi.org/10.1111/j.1742-4658.2010.07771.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2975871PMC
September 2010

Role of valine 464 in the flavin oxidation reaction catalyzed by choline oxidase.

Biochemistry 2010 Apr;49(13):2952-61

Department of Chemistry, Georgia State University, Atlanta, Georgia 30302-4098, USA.

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http://dx.doi.org/10.1021/bi902048cDOI Listing
April 2010

Highly conserved glycine 86 and arginine 87 residues contribute differently to the structure and activity of the mature HIV-1 protease.

Proteins 2010 Mar;78(4):1015-25

Department of Structural Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15260, USA.

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http://doi.wiley.com/10.1002/prot.22625
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http://dx.doi.org/10.1002/prot.22625DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2811763PMC
March 2010

HIV-1 Protease: Structural Perspectives on Drug Resistance.

Viruses 2009 12 3;1(3):1110-36. Epub 2009 Dec 3.

Department of Biology, Molecular Basis of Disease Program, Georgia State University, Atlanta, GA 30303, USA; E-Mail:

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http://dx.doi.org/10.3390/v1031110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3185505PMC
December 2009

Conformational similarity in the activation of caspase-3 and -7 revealed by the unliganded and inhibited structures of caspase-7.

Apoptosis 2009 Oct;14(10):1135-44

Department of Biology, Georgia State University, Atlanta, GA 30303, USA.

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http://dx.doi.org/10.1007/s10495-009-0388-9DOI Listing
October 2009

Caspase-3 binds diverse P4 residues in peptides as revealed by crystallography and structural modeling.

Apoptosis 2009 May;14(5):741-52

Department of Biology, Molecular Basis of Disease Program, Georgia State University, Atlanta, GA 30303, USA.

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http://dx.doi.org/10.1007/s10495-009-0333-yDOI Listing
May 2009

Drug targets in human T-lymphotropic virus type 1 (HTLV-1) infection.

Infect Disord Drug Targets 2009 Apr;9(2):159-71

Department of Biochemistry and Molecular Biology, Faculty of Medicine, Debrecen University, Debrecen, Hungary.

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http://dx.doi.org/10.2174/187152609787847686DOI Listing
April 2009

Defining the DNA substrate binding sites on HIV-1 integrase.

J Mol Biol 2009 Jan 7;385(2):568-79. Epub 2008 Nov 7.

Department of Microbiology and Immunology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S002228360801396
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http://dx.doi.org/10.1016/j.jmb.2008.10.083DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2778331PMC
January 2009

C-terminal residues of mature human T-lymphotropic virus type 1 protease are critical for dimerization and catalytic activity.

Biochem J 2008 Dec;416(3):357-64

Department of Biochemistry and Molecular Biology, Research Center for Molecular Medicine, Medical and Health Science Center, University of Debrecen H-4012, Hungary.

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http://dx.doi.org/10.1042/BJ20071132DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2778851PMC
December 2008

Structural evidence for effectiveness of darunavir and two related antiviral inhibitors against HIV-2 protease.

J Mol Biol 2008 Dec 20;384(1):178-92. Epub 2008 Sep 20.

Department of Biology, Molecular Basis of Disease Program, Georgia State University, Atlanta, GA 30303, USA.

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http://dx.doi.org/10.1016/j.jmb.2008.09.031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2597724PMC
December 2008

Structural basis for executioner caspase recognition of P5 position in substrates.

Apoptosis 2008 Nov;13(11):1291-302

Department of Biology, Molecular Basis of Disease Program, Georgia State University, Atlanta, GA 30303, USA.

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http://dx.doi.org/10.1007/s10495-008-0259-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2782447PMC
November 2008

Amino acid preferences of retroviral proteases for amino-terminal positions in a type 1 cleavage site.

J Virol 2008 Oct 13;82(20):10111-7. Epub 2008 Aug 13.

University of Debrecen, Department of Biochemistry and Molecular Biology, Nagyerdei krt. 98, Debrecen H-4012, Hungary.

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http://dx.doi.org/10.1128/JVI.00418-08DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2566267PMC
October 2008

Solution kinetics measurements suggest HIV-1 protease has two binding sites for darunavir and amprenavir.

J Med Chem 2008 Oct 20;51(20):6599-603. Epub 2008 Sep 20.

Departments of Biology and Chemistry, Molecular Basis of Disease Program, Georgia State University, Atlanta, Georgia 30303, USA.

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http://dx.doi.org/10.1021/jm800283kDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2771923PMC
October 2008

Caspases: structure-guided design of drugs to control cell death.

Mini Rev Med Chem 2008 Oct;8(11):1154-62

Department of Biology, Georgia State University, P.O. Box 4010, Atlanta, GA 30302, USA.

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http://dx.doi.org/10.2174/138955708785909899DOI Listing
October 2008

Effect of flap mutations on structure of HIV-1 protease and inhibition by saquinavir and darunavir.

J Mol Biol 2008 Aug 1;381(1):102-15. Epub 2008 Jul 1.

Department of Biology, Molecular Basis of Disease Program, Georgia State University, Atlanta, GA 30303, USA.

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http://dx.doi.org/10.1016/j.jmb.2008.05.062DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2754059PMC
August 2008

Effect of the active site D25N mutation on the structure, stability, and ligand binding of the mature HIV-1 protease.

J Biol Chem 2008 May 15;283(19):13459-70. Epub 2008 Feb 15.

Laboratory of Chemical Physics, NIDDK, National Institutes of Health, Bethesda, Maryland 20892-0520, USA.

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http://dx.doi.org/10.1074/jbc.M708506200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2442353PMC
May 2008

Design of HIV protease inhibitors targeting protein backbone: an effective strategy for combating drug resistance.

Acc Chem Res 2008 Jan 28;41(1):78-86. Epub 2007 Aug 28.

Department of Chemistry, Purdue University, West Lafayette, Indiana 47907, USA.

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http://dx.doi.org/10.1021/ar7001232DOI Listing
January 2008

Caught in the Act: the 1.5 A resolution crystal structures of the HIV-1 protease and the I54V mutant reveal a tetrahedral reaction intermediate.

Biochemistry 2007 Dec 4;46(51):14854-64. Epub 2007 Dec 4.

Department of Biology and Chemistry, Molecular Basis of Disease Program, Georgia State University, Atlanta, Georgia 30303, USA.

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http://dx.doi.org/10.1021/bi700822gDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2546526PMC
December 2007

Potent new antiviral compound shows similar inhibition and structural interactions with drug resistant mutants and wild type HIV-1 protease.

J Med Chem 2007 Sep 16;50(18):4509-15. Epub 2007 Aug 16.

Department of Biology, Molecular Basis of Disease, Georgia State University, Atlanta, Georgia 30303, USA.

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http://dx.doi.org/10.1021/jm070482qDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2751596PMC
September 2007

Plasticity of S2-S4 specificity pockets of executioner caspase-7 revealed by structural and kinetic analysis.

FEBS J 2007 Sep 14;274(18):4752-65. Epub 2007 Aug 14.

Department of Biology, Molecular Basis of Disease, Georgia State University, Atlanta, GA 30302, USA.

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http://dx.doi.org/10.1111/j.1742-4658.2007.05994.xDOI Listing
September 2007

HIV-1 protease: structure, dynamics, and inhibition.

Adv Pharmacol 2007 ;55:261-98

Laboratory of Chemical Physics, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1016/S1054-3589(07)55008-8DOI Listing
August 2007

The protease of human T-cell leukemia virus type-1 is a potential therapeutic target.

Curr Pharm Des 2007 ;13(12):1285-94

Department of Biochemistry and Molecular Biology, Research Center for Molecular Medicine, Debrecen University, Debrecen, Hungary.

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http://dx.doi.org/10.2174/138161207780618849DOI Listing
July 2007

Structure based drug design for HIV protease: from molecular modeling to cheminformatics.

Curr Top Med Chem 2007 ;7(10):1030-8

Department of Chemistry, Georgia State University, Atlanta, Georgia 30303, USA.

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http://dx.doi.org/10.2174/156802607780906744DOI Listing
July 2007

Bovine leukemia virus protease: comparison with human T-lymphotropic virus and human immunodeficiency virus proteases.

J Gen Virol 2007 Jul;88(Pt 7):2052-63

Department of Biochemistry and Molecular Biology, Research Center for Molecular Medicine, Medical and Health Science Center, University of Debrecen, Hungary.

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http://dx.doi.org/10.1099/vir.0.82704-0DOI Listing
July 2007

A novel bis-tetrahydrofuranylurethane-containing nonpeptidic protease inhibitor (PI), GRL-98065, is potent against multiple-PI-resistant human immunodeficiency virus in vitro.

Antimicrob Agents Chemother 2007 Jun 19;51(6):2143-55. Epub 2007 Mar 19.

Departments of Infectious Diseases and Hematology, Kumamoto University School of Medicine, 1-1-1 Honjo, Kumamoto 860-8556, Japan.

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http://dx.doi.org/10.1128/AAC.01413-06DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1891396PMC
June 2007

Atomic resolution crystal structures of HIV-1 protease and mutants V82A and I84V with saquinavir.

Proteins 2007 Apr;67(1):232-42

Department of Chemistry, Georgia State University, Atlanta, Georgia 30303, USA.

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http://dx.doi.org/10.1002/prot.21304DOI Listing
April 2007

Crystal structure of the Geobacillus stearothermophilus carboxylesterase Est55 and its activation of prodrug CPT-11.

J Mol Biol 2007 Mar 30;367(1):212-23. Epub 2006 Dec 30.

Department of Biology, Molecular Basis of Disease Program, Georgia State University, Atlanta, GA 30303, USA.

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http://dx.doi.org/10.1016/j.jmb.2006.12.067DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1950602PMC
March 2007

Molecular basis for differential nucleotide binding of the nucleotide-binding domain of ABC-transporter CvaB.

Biochemistry 2006 Dec;45(48):14473-80

Department of Biology, Georgia State University, Atlanta, Georgia 30303, USA.

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http://dx.doi.org/10.1021/bi061506iDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2515628PMC
December 2006

Ultra-high resolution crystal structure of HIV-1 protease mutant reveals two binding sites for clinical inhibitor TMC114.

J Mol Biol 2006 Oct 4;363(1):161-73. Epub 2006 Aug 4.

Department of Biology, Molecular Basis of Disease, GA State University, Atlanta, GA 30303, USA.

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http://dx.doi.org/10.1016/j.jmb.2006.08.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1781337PMC
October 2006

Structural and kinetic analysis of caspase-3 reveals role for s5 binding site in substrate recognition.

J Mol Biol 2006 Jul 2;360(3):654-66. Epub 2006 Jun 2.

Department of Biology, Molecular Basis of Disease, Georgia State University, Atlanta, GA 30303, USA.

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http://dx.doi.org/10.1016/j.jmb.2006.05.041DOI Listing
July 2006

Characterization of the murine leukemia virus protease and its comparison with the human immunodeficiency virus type 1 protease.

J Gen Virol 2006 May;87(Pt 5):1321-30

Department of Biochemistry and Molecular Biology, Research Center for Molecular Medicine, Medical and Health Science Center, University of Debrecen, Hungary.

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http://dx.doi.org/10.1099/vir.0.81382-0DOI Listing
May 2006