Publications by authors named "Irene Slavc"

75Publications

Cerebrospinal fluid penetration of targeted therapeutics in pediatric brain tumor patients.

Acta Neuropathol Commun 2020 06 3;8(1):78. Epub 2020 Jun 3.

Department of Pediatrics and Adolescent Medicine and Comprehensive Center for Pediatrics, Medical University of Vienna, Währinger Gürtel 18-20, 1090, Vienna, Austria.

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http://dx.doi.org/10.1186/s40478-020-00953-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7268320PMC
June 2020

Infant High-Grade Gliomas Comprise Multiple Subgroups Characterized by Novel Targetable Gene Fusions and Favorable Outcomes.

Authors:
Matthew Clarke Alan Mackay Britta Ismer Jessica C Pickles Ruth G Tatevossian Scott Newman Tejus A Bale Iris Stoler Elisa Izquierdo Sara Temelso Diana M Carvalho Valeria Molinari Anna Burford Louise Howell Alex Virasami Amy R Fairchild Aimee Avery Jane Chalker Mark Kristiansen Kelly Haupfear James D Dalton Wilda Orisme Ji Wen Michael Hubank Kathreena M Kurian Catherine Rowe Mellissa Maybury Stephen Crosier Jeffrey Knipstein Ulrich Schüller Uwe Kordes David E Kram Matija Snuderl Leslie Bridges Andrew J Martin Lawrence J Doey Safa Al-Sarraj Christopher Chandler Bassel Zebian Claire Cairns Rachael Natrajan Jessica K R Boult Simon P Robinson Martin Sill Ira J Dunkel Stephen W Gilheeney Marc K Rosenblum Debbie Hughes Paula Z Proszek Tobey J Macdonald Matthias Preusser Christine Haberler Irene Slavc Roger Packer Ho-Keung Ng Shani Caspi Mara Popović Barbara Faganel Kotnik Matthew D Wood Lissa Baird Monika Ashok Davare David A Solomon Thale Kristin Olsen Petter Brandal Michael Farrell Jane B Cryan Michael Capra Michael Karremann Jens Schittenhelm Martin U Schuhmann Martin Ebinger Winand N M Dinjens Kornelius Kerl Simone Hettmer Torsten Pietsch Felipe Andreiuolo Pablo Hernáiz Driever Andrey Korshunov Lotte Hiddingh Barbara C Worst Dominik Sturm Marc Zuckermann Olaf Witt Tabitha Bloom Clare Mitchell Evelina Miele Giovanna Stefania Colafati Francesca Diomedi-Camassei Simon Bailey Andrew S Moore Timothy E G Hassall Stephen P Lowis Maria Tsoli Mark J Cowley David S Ziegler Matthias A Karajannis Kristian Aquilina Darren R Hargrave Fernando Carceller Lynley V Marshall Andreas von Deimling Christof M Kramm Stefan M Pfister Felix Sahm Suzanne J Baker Angela Mastronuzzi Andrea Carai Maria Vinci David Capper Sergey Popov David W Ellison Thomas S Jacques David T W Jones Chris Jones

Cancer Discov 2020 Jul 1;10(7):942-963. Epub 2020 Apr 1.

Division of Molecular Pathology, Institute of Cancer Research, London, United Kingdom.

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http://dx.doi.org/10.1158/2159-8290.CD-19-1030DOI Listing
July 2020

Cerebrospinal fluid disturbances after transcallosal surgery: incidence and predictive factors.

J Neurosurg 2019 Sep 27:1-9. Epub 2019 Sep 27.

1Department of Neurosurgery, Medical University of Vienna.

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http://dx.doi.org/10.3171/2019.6.JNS19290DOI Listing
September 2019

High impact of miRNA-4521 on FOXM1 expression in medulloblastoma.

Cell Death Dis 2019 09 20;10(10):696. Epub 2019 Sep 20.

Department of Pediatrics and Adolescent Medicine, Molecular Neuro-Oncology, Medical University of Vienna, Vienna, Austria.

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http://dx.doi.org/10.1038/s41419-019-1926-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6754377PMC
September 2019

An Integrative Model of Cellular States, Plasticity, and Genetics for Glioblastoma.

Cell 2019 08 18;178(4):835-849.e21. Epub 2019 Jul 18.

Department of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA, 02114, USA; Klarman Cell Observatory, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2019.06.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6703186PMC
August 2019

Predisposition of Wingless Subgroup Medulloblastoma for Primary Tumor Hemorrhage.

Neurosurgery 2020 04;86(4):478-484

Department of Pediatrics and Adolescent Medicine, Medical University of Vienna, Vienna, Austria.

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http://dx.doi.org/10.1093/neuros/nyz148DOI Listing
April 2020

Management of choroid plexus tumors-an institutional experience.

Acta Neurochir (Wien) 2019 04 19;161(4):745-754. Epub 2019 Feb 19.

Department of Neurosurgery, Medical University of Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria.

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http://link.springer.com/10.1007/s00701-019-03832-5
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http://dx.doi.org/10.1007/s00701-019-03832-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431303PMC
April 2019

Does the interval from tumour surgery to radiotherapy influence survival in paediatric high grade glioma?

Strahlenther Onkol 2018 06 18;194(6):552-559. Epub 2018 Jan 18.

Department of Pediatrics and Adolescent Medicine, Medical University of Vienna, Spitalgasse 23, 1090, Vienna, Austria.

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http://link.springer.com/10.1007/s00066-018-1260-z
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http://dx.doi.org/10.1007/s00066-018-1260-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5959993PMC
June 2018

From Symptom to Diagnosis-The Prediagnostic Symptomatic Interval of Pediatric Central Nervous System Tumors in Austria.

Pediatr Neurol 2017 Nov 18;76:27-36. Epub 2017 Aug 18.

Division of Neonatology, Pediatric Intensive Care and Neuropediatrics, Department of Pediatrics and Adolescent Medicine, Medical University of Vienna, Vienna, Austria.

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http://dx.doi.org/10.1016/j.pediatrneurol.2017.08.006DOI Listing
November 2017

Do we still need IQ-scores? Misleading interpretations of neurocognitive outcome in pediatric patients with medulloblastoma: a retrospective study.

J Neurooncol 2017 Nov 4;135(2):361-369. Epub 2017 Aug 4.

Department of Pediatrics and Adolescent Medicine, Medical University of Vienna, Waehringer Guertel 18-20, Vienna, Austria.

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http://dx.doi.org/10.1007/s11060-017-2582-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5663794PMC
November 2017

Pharmacokinetics of Bevacizumab in Three Patients Under the Age of 3 Years with CNS Malignancies.

Drugs R D 2017 Sep;17(3):469-474

Department of Pediatrics, Medical University of Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria.

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http://dx.doi.org/10.1007/s40268-017-0190-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5629131PMC
September 2017

Telomerase activation in posterior fossa group A ependymomas is associated with dismal prognosis and chromosome 1q gain.

Neuro Oncol 2017 Sep;19(9):1183-1194

Department of Pediatrics and Adolescent Medicine, Medical University of Vienna, Austria; Comprehensive Cancer Center, Medical University of Vienna, Austria; Institute of Cancer Research, Department of Medicine I, Medical University of Vienna, Austria; Neuromed Campus, Kepler University Hospital, Linz, Austria; Institute of Neurology, Medical University of Vienna, Austria; Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), Heidelberg, Germany; Department of Pediatric Oncology, Hematology and Immunology, University Hospital Heidelberg, Germany; German Cancer Consortium (DKTK), Heidelberg, Germany; Clinical Cooperation Unit Neuropathology, German Cancer Research Center (DKFZ), Heidelberg, Germany; Department of Neuropathology, University Hospital Heidelberg, Germany; Division of Molecular Genetics, German Cancer Research Center (DKFZ), Heidelberg, Germany; Department of Neurosurgery, Medical University of Vienna, Austria; Department of Radiotherapy, Medical University of Vienna, Austria.

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http://dx.doi.org/10.1093/neuonc/nox027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5570194PMC
September 2017

Applying the International Classification of Functioning-Children and Youth Version to Pediatric Neuro-oncology.

J Child Neurol 2017 01 6;32(1):23-28. Epub 2016 Oct 6.

1 Department of Pediatrics and Adolescent Medicine, Medical University of Vienna, Vienna, Austria.

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http://dx.doi.org/10.1177/0883073816669647DOI Listing
January 2017

Development of the SIOPE DIPG network, registry and imaging repository: a collaborative effort to optimize research into a rare and lethal disease.

J Neurooncol 2017 04 21;132(2):255-266. Epub 2017 Jan 21.

Department of Paediatrics, Division of Oncology/Haematology, VU University Medical Center, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1007/s11060-016-2363-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5378734PMC
April 2017

Intracerebroventricular Delivery as a Safe, Long-Term Route of Drug Administration.

Pediatr Neurol 2017 02 10;67:23-35. Epub 2016 Nov 10.

Department of Pediatrics and Adolescent Medicine, Medical University of Vienna, Vienna, Austria. Electronic address:

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http://dx.doi.org/10.1016/j.pediatrneurol.2016.10.022DOI Listing
February 2017

Trends in incidence, survival and mortality of childhood and adolescent cancer in Austria, 1994-2011.

Cancer Epidemiol 2016 06 4;42:72-81. Epub 2016 Apr 4.

The Children Cancer Research Institute, St. Anna Children's Hospital, Kinderspitalgasse 6, 1090 Vienna, Austria. Electronic address:

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http://dx.doi.org/10.1016/j.canep.2016.03.015DOI Listing
June 2016

New Brain Tumor Entities Emerge from Molecular Classification of CNS-PNETs.

Authors:
Dominik Sturm Brent A Orr Umut H Toprak Volker Hovestadt David T W Jones David Capper Martin Sill Ivo Buchhalter Paul A Northcott Irina Leis Marina Ryzhova Christian Koelsche Elke Pfaff Sariah J Allen Gnanaprakash Balasubramanian Barbara C Worst Kristian W Pajtler Sebastian Brabetz Pascal D Johann Felix Sahm Jüri Reimand Alan Mackay Diana M Carvalho Marc Remke Joanna J Phillips Arie Perry Cynthia Cowdrey Rachid Drissi Maryam Fouladi Felice Giangaspero Maria Łastowska Wiesława Grajkowska Wolfram Scheurlen Torsten Pietsch Christian Hagel Johannes Gojo Daniela Lötsch Walter Berger Irene Slavc Christine Haberler Anne Jouvet Stefan Holm Silvia Hofer Marco Prinz Catherine Keohane Iris Fried Christian Mawrin David Scheie Bret C Mobley Matthew J Schniederjan Mariarita Santi Anna M Buccoliero Sonika Dahiya Christof M Kramm André O von Bueren Katja von Hoff Stefan Rutkowski Christel Herold-Mende Michael C Frühwald Till Milde Martin Hasselblatt Pieter Wesseling Jochen Rößler Ulrich Schüller Martin Ebinger Jens Schittenhelm Stephan Frank Rainer Grobholz Istvan Vajtai Volkmar Hans Reinhard Schneppenheim Karel Zitterbart V Peter Collins Eleonora Aronica Pascale Varlet Stephanie Puget Christelle Dufour Jacques Grill Dominique Figarella-Branger Marietta Wolter Martin U Schuhmann Tarek Shalaby Michael Grotzer Timothy van Meter Camelia-Maria Monoranu Jörg Felsberg Guido Reifenberger Matija Snuderl Lynn Ann Forrester Jan Koster Rogier Versteeg Richard Volckmann Peter van Sluis Stephan Wolf Tom Mikkelsen Amar Gajjar Kenneth Aldape Andrew S Moore Michael D Taylor Chris Jones Nada Jabado Matthias A Karajannis Roland Eils Matthias Schlesner Peter Lichter Andreas von Deimling Stefan M Pfister David W Ellison Andrey Korshunov Marcel Kool

Cell 2016 Feb;164(5):1060-1072

Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), 69120 Heidelberg, Germany.

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http://www.cell.com/cell/pdf/S0092-8674(16)00055-6.pdf
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http://www.cell.com/cms/attachment/2048488015/2058390163/mmc
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http://linkinghub.elsevier.com/retrieve/pii/S009286741600055
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http://dx.doi.org/10.1016/j.cell.2016.01.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5139621PMC
February 2016

Pharmacokinetics and toxicity of intrathecal liposomal cytarabine in children and adolescents following age-adapted dosing.

Clin Pharmacokinet 2014 Feb;53(2):165-73

Department of Pediatrics, Medical University of Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria.

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http://dx.doi.org/10.1007/s40262-013-0106-1DOI Listing
February 2014

High plasma-GFAP levels in metastatic myxopapillary ependymoma.

J Neurooncol 2013 Jul 29;113(3):359-63. Epub 2013 Apr 29.

Clinical Division of Oncology, Department of Medicine I, Medical University of Vienna, Vienna, Austria.

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http://dx.doi.org/10.1007/s11060-013-1134-2DOI Listing
July 2013

Antiangiogenic metronomic therapy for children with recurrent embryonal brain tumors.

Pediatr Blood Cancer 2012 Sep 6;59(3):511-7. Epub 2011 Dec 6.

Department of Pediatrics, Medical University of Vienna, Austria.

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http://dx.doi.org/10.1002/pbc.24006DOI Listing
September 2012

Identification of c-myc-dependent proteins in the medulloblastoma cell line D425Med.

Amino Acids 2012 Jun 12;42(6):2149-63. Epub 2011 Jun 12.

Department of Pediatrics, Medical University of Vienna, Währinger Gürtel 18, 1090, Vienna, Austria.

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http://dx.doi.org/10.1007/s00726-011-0953-8DOI Listing
June 2012

Feasibility and tolerability of bevacizumab in children with primary CNS tumors.

Pediatr Blood Cancer 2010 May;54(5):681-6

Department of Pediatrics, Medical University of Vienna, Vienna, Austria.

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http://dx.doi.org/10.1002/pbc.22409DOI Listing
May 2010

Pharmacokinetics and safety of intrathecal liposomal cytarabine in children aged <3 years.

Clin Pharmacokinet 2009 ;48(4):265-71

Department of Paediatrics, Medical University of Vienna, Vienna, Austria.

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http://dx.doi.org/10.2165/00003088-200948040-00004DOI Listing
September 2009

Neurotrophin 3/TrkC-regulated proteins in the human medulloblastoma cell line DAOY.

Electrophoresis 2009 Feb;30(3):540-9

Department of Pediatrics, Medical University of Vienna, Vienna, Austria.

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http://doi.wiley.com/10.1002/elps.200800325
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http://dx.doi.org/10.1002/elps.200800325DOI Listing
February 2009

Tumor stabilization under treatment with imatinib in progressive hypothalamic-chiasmatic glioma.

Pediatr Blood Cancer 2009 Apr;52(4):476-80

Department of Pediatrics, Medical University of Vienna, Vienna, Austria.

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http://dx.doi.org/10.1002/pbc.21881DOI Listing
April 2009

Mitosis-dependent protein expression in neuroblastoma cell line N1E-115.

J Proteome Res 2008 Aug 27;7(8):3412-22. Epub 2008 Jun 27.

Department of Pediatrics and Adolescent Medicine, Medical University of Vienna, Wahringer Gurtel 18-20, Vienna, Austria.

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http://dx.doi.org/10.1021/pr800149pDOI Listing
August 2008

Synthesis, chaperoning, and metabolism of proteins are regulated by NT-3/TrkC signaling in the medulloblastoma cell line DAOY.

J Proteome Res 2008 May 13;7(5):1932-44. Epub 2008 Mar 13.

Department of Pediatrics, Medical University of Vienna, Vienna, Austria.

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http://dx.doi.org/10.1021/pr700724aDOI Listing
May 2008

Papillary glioneuronal tumor.

Neuropathology 2007 Oct;27(5):468-73

Institute of Neurology, Medical University of Vienna, Vienna, Austria.

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http://dx.doi.org/10.1111/j.1440-1789.2007.00802.xDOI Listing
October 2007

Protein chemical identification and characterization of the human variants of far upstream element binding protein in medulloblastoma DAOY cell line.

Int J Oncol 2006 Sep;29(3):721-36

Department of Pediatrics, Medical University of Vienna, A-1090, Vienna, Austria.

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September 2006

Mass spectrometric identification of serine hydrolase OVCA2 in the medulloblastoma cell line DAOY.

Cancer Lett 2006 Sep 20;241(2):235-49. Epub 2005 Dec 20.

Department of Pediatrics, Medical University of Vienna, Währinger Gürtel 19-21, A-1090 Vienna, Austria.

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http://linkinghub.elsevier.com/retrieve/pii/S030438350500937
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http://dx.doi.org/10.1016/j.canlet.2005.10.023DOI Listing
September 2006

Comparative proteomic analysis of nucleic acid-binding proteins in ten human tumor cell lines.

Int J Oncol 2006 Jan;28(1):173-90

Department of Pediatrics, Medical University of Vienna, Vienna, Austria.

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January 2006

The medulloblastoma cell line DAOY but not eleven other tumor cell lines expresses minichromosome maintenance protein 4.

Cancer Lett 2006 Jul 26;238(1):76-84. Epub 2005 Jul 26.

Department of Pediatrics, Medical University of Vienna, Waehringer Guertel 18-20, A-1090 Vienna, Austria.

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http://dx.doi.org/10.1016/j.canlet.2005.06.024DOI Listing
July 2006

Detection of hypothetical proteins in 10 individual human tumor cell lines.

Biochim Biophys Acta 2005 Feb 1;1747(1):67-80. Epub 2004 Nov 1.

Medical University of Vienna, Division of Basic Science, Department of Pediatrics, Währinger Gürtel 18, A-1090 Vienna, Austria.

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http://dx.doi.org/10.1016/j.bbapap.2004.09.024DOI Listing
February 2005

Vascularization and expression of hypoxia-related tissue factors in intracranial ependymoma and their impact on patient survival.

Acta Neuropathol 2005 Feb 22;109(2):211-6. Epub 2004 Dec 22.

Institute of Neurology, Medical University Vienna, AKH 4J, Waehringer Guertel 18-20, PO Box 48, 1097, Vienna, Austria.

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http://dx.doi.org/10.1007/s00401-004-0938-8DOI Listing
February 2005

Expressional patterns of chaperones in ten human tumor cell lines.

Proteome Sci 2004 Dec 14;2(1). Epub 2004 Dec 14.

Department of Pediatrics, Medical University of Vienna, Vienna, Austria.

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http://proteomesci.biomedcentral.com/articles/10.1186/1477-5
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http://dx.doi.org/10.1186/1477-5956-2-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC543454PMC
December 2004

Proteomic Profiling of Signaling Proteins in Ten Different Tumor Cell Lines.

Cancer Genomics Proteomics 2004 Sep-Dec;1(5-6):427-454. Epub 2004 Sep 1.

Department of Pediatrcs, Division of Basic Sciences, Medical University of Vienna, Vienna, Austria.

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September 2004

Proteomic Determination of Metabolic Protein Expression in Ten Different Tumor Cell Lines.

Cancer Genomics Proteomics 2004 Jul-Aug;1(4):311-338. Epub 2004 Jul 1.

Department of Pediatrics, Division of Basic Sciences, Medical University of Vienna, Vienna, Austria.

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July 2004

Ki-67 immunolabeling index is an accurate predictor of outcome in patients with intracranial ependymoma.

Am J Surg Pathol 2004 Jul;28(7):914-20

Department of Neurosurgery, University of Vienna Medical School, Vienna General Hospital, Vienna, Austria.

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http://dx.doi.org/10.1097/00000478-200407000-00011DOI Listing
July 2004

Hypothetical proteins with putative enzyme activity in human amnion, lymphocyte, bronchial epithelial and kidney cell lines.

Biochim Biophys Acta 2004 Jul;1700(1):65-74

Department of Pediatrics, Division of Basic Science, University of Vienna, Währinger Gürtel 18, A-1090 Vienna, Austria.

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http://dx.doi.org/10.1016/j.bbapap.2004.03.014DOI Listing
July 2004

Protein Profiling of the Supratentorial Primitive Neuroectodermal Tumor (PNET) Cell Line PFSK-1.

Cancer Genomics Proteomics 2004 Mar-Apr;1(2):125-136. Epub 2004 Mar 1.

Department of Pediatrics, Medical University of Vienna, Vienna, Austria.

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March 2004

Proteomic characterization of the human cortical neuronal cell line HCN-2.

J Chem Neuroanat 2003 Nov;26(3):171-8

Department of Pediatrics, University of Vienna, Waehringer Guertel 18-20, A 1090 Vienna, Austria.

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http://dx.doi.org/10.1016/s0891-0618(03)00079-6DOI Listing
November 2003