Publications by authors named "Irene Roberts"

100Publications

The genesis of paediatric haematology in the UK.

Br J Haematol 2020 Nov;191(4):593-603

Professor Emeritus, UCL and Institute of Child Health London, Consultant Haematologist Irish Blood Transfusion Service, St Finbarr's Hospital Cork, Cork, Republic of Ireland.

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http://dx.doi.org/10.1111/bjh.17163DOI Listing
November 2020

Sensitive, rapid diagnostic test for transient abnormal myelopoiesis and myeloid leukemia of Down syndrome.

Blood 2020 Sep;136(12):1460-1465

Medical Research Council Molecular Haematology Unit, BRC Haematology Theme, Oxford Biomedical Research Centre, Oxford Centre for Haematology, Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom.

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http://dx.doi.org/10.1182/blood.2020005610DOI Listing
September 2020

Single-Cell Analyses Reveal Megakaryocyte-Biased Hematopoiesis in Myelofibrosis and Identify Mutant Clone-Specific Targets.

Mol Cell 2020 05;78(3):477-492.e8

Haematopoietic Stem Cell Biology Laboratory, Medical Research Council (MRC) Weatherall Institute of Molecular Medicine (WIMM), University of Oxford, Oxford OX3 9DS, UK; MRC Molecular Haematology Unit, MRC WIMM, University of Oxford, Oxford OX3 9DS, UK; NIHR Biomedical Research Centre, University of Oxford, Oxford OX4 2PG, UK. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2020.04.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7217381PMC
May 2020

H3K79me2/3 controls enhancer-promoter interactions and activation of the pan-cancer stem cell marker PROM1/CD133 in MLL-AF4 leukemia cells.

Leukemia 2020 Apr 2. Epub 2020 Apr 2.

MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, NIHR Oxford Biomedical Research Centre Haematology Theme, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1038/s41375-020-0808-yDOI Listing
April 2020

Impaired cellular and humoral immunity is a feature of Diamond-Blackfan anaemia; experience of 107 unselected cases in the United Kingdom.

Br J Haematol 2019 07 13;186(2):321-326. Epub 2019 Apr 13.

Centre for Haematology, Department of Medicine, Hammersmith Hospital, Imperial College London, London, UK.

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http://dx.doi.org/10.1111/bjh.15915DOI Listing
July 2019

A Novel Deletion in the RPL5 Gene in a Lebanese Child With Diamond Blackfan Anemia Unresponsive to Steroid Treatment.

J Pediatr Hematol Oncol 2020 05;42(4):e235-e237

Department of Pediatrics, University of Freiburg, Freiburg, Germany.

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http://dx.doi.org/10.1097/MPH.0000000000001435DOI Listing
May 2020

Single-cell assessment of transcriptome alterations induced by Scriptaid in early differentiated human haematopoietic progenitors during ex vivo expansion.

Sci Rep 2019 03 28;9(1):5300. Epub 2019 Mar 28.

Stem Cell Research, Nuffield Division of Clinical Laboratory Sciences, Radcliffe Department of Medicine, University of Oxford, and NHS Blood and Transplant, John Radcliffe Hospital, Oxford, OX3 9BQ, UK.

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http://www.nature.com/articles/s41598-019-41803-z
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http://dx.doi.org/10.1038/s41598-019-41803-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6438964PMC
March 2019

Neonatal leukaemia.

Br J Haematol 2018 07 28;182(2):170-184. Epub 2018 May 28.

St Mary's Hospital campus of Imperial College London, St Mary's Hospital, London, UK.

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http://dx.doi.org/10.1111/bjh.15246DOI Listing
July 2018

High resolution IgH repertoire analysis reveals fetal liver as the likely origin of life-long, innate B lymphopoiesis in humans.

Clin Immunol 2017 10 20;183:8-16. Epub 2017 Jun 20.

Centre for Haematology, Department of Medicine, Imperial College London, Imperial College Healthcare NHS Trust, Hammersmith Hospital, London, UK. Electronic address:

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http://dx.doi.org/10.1016/j.clim.2017.06.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5678457PMC
October 2017

Sickle cell disease: the price of cure.

Blood 2016 11;128(21):2486-2488

IMPERIAL COLLEGE HEALTHCARE.

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http://www.bloodjournal.org/lookup/doi/10.1182/blood-2016-10
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http://dx.doi.org/10.1182/blood-2016-10-740969DOI Listing
November 2016

Transient Abnormal Myelopoiesis and AML in Down Syndrome: an Update.

Curr Hematol Malig Rep 2016 10;11(5):333-41

Department of Paediatrics, Children's Hospital, University of Oxford, John Radcliffe Hospital, OX3 9DU, Oxford, UK.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5031718PMC
http://dx.doi.org/10.1007/s11899-016-0338-xDOI Listing
October 2016

Elucidation of the EP defect in Diamond-Blackfan anemia by characterization and prospective isolation of human EPs.

Blood 2015 Apr 9;125(16):2553-7. Epub 2015 Mar 9.

Centre for Haematology, Department of Medicine, Hammersmith Hospital, Imperial College London, London, United Kingdom;

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http://dx.doi.org/10.1182/blood-2014-10-608042DOI Listing
April 2015

Stem and progenitor cell dysfunction in human trisomies.

EMBO Rep 2015 Jan 17;16(1):44-62. Epub 2014 Dec 17.

Department of Paediatrics and Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, Oxford, UK

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http://dx.doi.org/10.15252/embr.201439583DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4304728PMC
January 2015

Down syndrome preleukemia and leukemia.

Pediatr Clin North Am 2015 Feb;62(1):121-37

MRC Molecular Haematology Unit, Department of Haematology, Weatherall Institute of Molecular Medicine, Oxford University Hospitals NHS Trust, University of Oxford, Oxford OX3 9DS, UK.

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http://dx.doi.org/10.1016/j.pcl.2014.09.009DOI Listing
February 2015

Cell-type-specific transcriptional regulation of PIGM underpins the divergent hematologic phenotype in inherited GPl deficiency.

Blood 2014 Nov 7;124(20):3151-4. Epub 2014 Oct 7.

Centre for Haematology, Department of Medicine, Hammersmith Hospital, Imperial College London, London, United Kingdom;

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http://dx.doi.org/10.1182/blood-2014-09-598813DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4231422PMC
November 2014

Nuclear proteasomes carry a constitutive posttranslational modification which derails SDS-PAGE (but not CTAB-PAGE).

Biochim Biophys Acta 2014 Dec 2;1844(12):2222-8. Epub 2014 Sep 2.

Centre for Haematology, Division of Experimental Medicine, Faculty of Medicine, Imperial College London, Hammersmith Campus, Commonwealth Building 4th Floor, Du Cane Road, London W12 0NN, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.bbapap.2014.08.013DOI Listing
December 2014

Haematopoietic development and leukaemia in Down syndrome.

Br J Haematol 2014 Dec 22;167(5):587-99. Epub 2014 Aug 22.

Paediatrics and Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1111/bjh.13096DOI Listing
December 2014

Factors predicting future ACS episodes in children with sickle cell anemia.

Am J Hematol 2014 Nov 27;89(11):E212-7. Epub 2014 Aug 27.

Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, Tennessee.

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http://dx.doi.org/10.1002/ajh.23819DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4866602PMC
November 2014

The impact of trisomy 21 on foetal haematopoiesis.

Blood Cells Mol Dis 2013 Dec 7;51(4):277-81. Epub 2013 Aug 7.

Centre for Haematology, Imperial College London, UK. Electronic address:

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http://linkinghub.elsevier.com/retrieve/pii/S107997961300159
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http://dx.doi.org/10.1016/j.bcmd.2013.07.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4727253PMC
December 2013

Target enrichment and high-throughput sequencing of 80 ribosomal protein genes to identify mutations associated with Diamond-Blackfan anaemia.

Br J Haematol 2013 Aug 30;162(4):530-6. Epub 2013 May 30.

Imperial Molecular Pathology Laboratory, Imperial College Healthcare NHS Trust and Academic Health Sciences Centre, Hammersmith Hospital, London, UK.

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http://dx.doi.org/10.1111/bjh.12397DOI Listing
August 2013

Mechanism of Polycomb recruitment to CpG islands revealed by inherited disease-associated mutation.

Hum Mol Genet 2013 Aug 15;22(16):3187-94. Epub 2013 Apr 15.

Centre for Haematology, Department of Medicine, Imperial College London, Du Cane Road, London W12 0NN, UK.

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http://hmg.oxfordjournals.org/content/early/2013/04/23/hmg.d
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http://www.hmg.oxfordjournals.org/cgi/doi/10.1093/hmg/ddt171
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http://dx.doi.org/10.1093/hmg/ddt171DOI Listing
August 2013

Changes in the fetal and neonatal cytokine profile in pregnancies complicated by fetal growth restriction.

Am J Reprod Immunol 2013 May 24;69(5):441-8. Epub 2012 Dec 24.

Queen Charlotte's and Chelsea Hospital, Imperial College, London, UK.

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http://dx.doi.org/10.1111/aji.12052DOI Listing
May 2013

Changes in the maternal cytokine profile in pregnancies complicated by fetal growth restriction.

Am J Reprod Immunol 2012 Jul 26;68(1):1-7. Epub 2012 Apr 26.

Queen Charlotte's and Chelsea Hospital, Imperial College, London, UK.

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http://dx.doi.org/10.1111/j.1600-0897.2012.01132.xDOI Listing
July 2012

Biology and management of transient abnormal myelopoiesis (TAM) in children with Down syndrome.

Semin Fetal Neonatal Med 2012 Aug 14;17(4):196-201. Epub 2012 Mar 14.

MRC Molecular Haematology Unit and Department of Haematology, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, United Kingdom. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S1744165X120003
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http://dx.doi.org/10.1016/j.siny.2012.02.010DOI Listing
August 2012

Enigmatic variation.

Blood 2011 Dec;118(26):6723-4

Imperial College London, University of Oxford, UK.

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http://dx.doi.org/10.1182/blood-2011-09-376145DOI Listing
December 2011

How I manage neonatal thrombocytopenia.

Br J Haematol 2012 Jan 27;156(2):155-62. Epub 2011 Sep 27.

Centre for Haematology, Imperial College London, London Department of Paediatrics, St Mary's Hospital, Imperial College Healthcare NHS Trust, London, UK.

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http://dx.doi.org/10.1111/j.1365-2141.2011.08892.xDOI Listing
January 2012

Managing the difficult case of fetal anemia.

J Matern Fetal Neonatal Med 2011 Dec 30;24(12):1498-503. Epub 2011 Jun 30.

Centre for Fetal and Maternal Medicine, Queen Charlotte's and Chelsea Hospital, Imperial College London , London, UK.

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http://dx.doi.org/10.3109/14767058.2010.551149DOI Listing
December 2011

Activated invariant NKT cells regulate osteoclast development and function.

J Immunol 2011 Mar 28;186(5):2910-7. Epub 2011 Jan 28.

Center for Hematology, Hammersmith Hospital, Imperial College London, London W12 0NN, United Kingdom.

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http://dx.doi.org/10.4049/jimmunol.1002353DOI Listing
March 2011

Perturbed hematopoiesis in the Tc1 mouse model of Down syndrome.

Blood 2010 Apr 12;115(14):2928-37. Epub 2010 Feb 12.

Division of Immune Cell Biology, Medical Research Council National Institute for Medical Research, London, UK.

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http://dx.doi.org/10.1182/blood-2009-06-227629DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2854435PMC
April 2010

Prospective, observational study of outcomes in neonates with severe thrombocytopenia.

Pediatrics 2009 Nov 19;124(5):e826-34. Epub 2009 Oct 19.

National Blood Service, Level 2, John Radcliffe Hospital, Headington, Oxford OX3 9BQ, England.

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http://pediatrics.aappublications.org/cgi/doi/10.1542/peds.2
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http://dx.doi.org/10.1542/peds.2009-0332DOI Listing
November 2009

Acute megakaryoblastic leukaemia (AMKL) and transient myeloproliferative disorder (TMD) in Down syndrome: a multi-step model of myeloid leukaemogenesis.

Br J Haematol 2009 Oct 6;147(1):3-12. Epub 2009 Jul 6.

Department of Haematology, Imperial College London, London, UK.

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http://dx.doi.org/10.1111/j.1365-2141.2009.07789.xDOI Listing
October 2009

Haemoglobin F modulation in childhood sickle cell disease.

Br J Haematol 2009 Feb 20;144(3):308-16. Epub 2008 Nov 20.

Department of Haematology, Great Ormond Street Hospital for Children NHS Trust, London, UK.

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http://dx.doi.org/10.1111/j.1365-2141.2008.07482.xDOI Listing
February 2009

Human invariant NKT cells display alloreactivity instructed by invariant TCR-CD1d interaction and killer Ig receptors.

J Immunol 2008 Sep;181(5):3268-76

Department of Hematology, Imperial College London, Hammersmith Hospital Campus, London, United Kingdom.

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http://dx.doi.org/10.4049/jimmunol.181.5.3268DOI Listing
September 2008

The changing face of haemolytic disease of the newborn.

Early Hum Dev 2008 Aug 14;84(8):515-23. Epub 2008 Jul 14.

Department of Haematology, Hammersmith Hospital, London W12 0NN, United Kingdom.

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http://linkinghub.elsevier.com/retrieve/pii/S037837820800118
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http://dx.doi.org/10.1016/j.earlhumdev.2008.06.005DOI Listing
August 2008

Thrombocytopenia in the neonate.

Blood Rev 2008 Jul 22;22(4):173-86. Epub 2008 Apr 22.

Paediatric Haematology, Imperial College, London, UK.

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http://linkinghub.elsevier.com/retrieve/pii/S0268960X0800023
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http://dx.doi.org/10.1016/j.blre.2008.03.004DOI Listing
July 2008

Neonatal thrombocytopenia.

Semin Fetal Neonatal Med 2008 Aug 18;13(4):256-64. Epub 2008 Apr 18.

Department of Haematology, Imperial College London and Imperial Healthcare NHS Trust, London, UK.

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http://dx.doi.org/10.1016/j.siny.2008.02.004DOI Listing
August 2008

Cord blood stem cell transplantation for haemoglobinopathies.

Br J Haematol 2008 May 26;141(3):309-24. Epub 2008 Feb 26.

Department of Paediatric Haematology, Imperial College Healthcare NHS Trust, London, UK.

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http://dx.doi.org/10.1111/j.1365-2141.2008.07016.xDOI Listing
May 2008

Haematology of Down syndrome.

Arch Dis Child Fetal Neonatal Ed 2007 Nov 5;92(6):F503-7. Epub 2007 Sep 5.

Department of Haematology and MRC Molecular Haematology Unit, John Radcliffe Hospital and Weatherall Institute of Molecular Medicine, Oxford OX3 9DU, England.

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http://dx.doi.org/10.1136/adc.2006.104638DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2675407PMC
November 2007

Matched-related donor transplantation for sickle cell disease: report from the Center for International Blood and Transplant Research.

Br J Haematol 2007 Jun 24;137(5):479-85. Epub 2007 Apr 24.

Department of Hematology/Oncology/Bone Marrow Transplant, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA.

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http://dx.doi.org/10.1111/j.1365-2141.2007.06592.xDOI Listing
June 2007

Targeted therapy for inherited GPI deficiency.

N Engl J Med 2007 Apr;356(16):1641-7

Department of Haematology, Imperial College London, Hammersmith Hospital, London, United Kingdom.

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http://dx.doi.org/10.1056/NEJMoa063369DOI Listing
April 2007

Haemolytic disease of the newborn.

Arch Dis Child Fetal Neonatal Ed 2007 Mar;92(2):F83-8

Imperial College, Department of Paediatrics, 5th Floor, Ham House, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK.

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http://fn.bmj.com/cgi/doi/10.1136/adc.2005.076794
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http://dx.doi.org/10.1136/adc.2005.076794DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2675453PMC
March 2007

Down myeloid disorders: a paradigm for childhood preleukaemia and leukaemia and insights into normal megakaryopoiesis.

Early Hum Dev 2006 Dec 24;82(12):767-73. Epub 2006 Oct 24.

Department of Haematology, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital and University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1016/j.earlhumdev.2006.09.016DOI Listing
December 2006

Neonatal thrombocytopenia.

Curr Hematol Rep 2006 Mar;5(1):55-63

Imperial College School of Medicine, Hammersmith Hospital, London W12 ONN, UK.

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March 2006

Correction of severe anaemia using immuno-regulated gene therapy is achieved by restoring the early erythroblast compartment.

Br J Haematol 2006 Mar;132(5):608-14

Lymphocyte Development Group, Medical Research Council, Clinical Sciences Centre, Imperial College London, Hammersmith Hospital, London, UK.

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http://doi.wiley.com/10.1111/j.1365-2141.2005.05905.x
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http://dx.doi.org/10.1111/j.1365-2141.2005.05905.xDOI Listing
March 2006

Management of Evans syndrome.

Br J Haematol 2006 Jan;132(2):125-37

Paediatric Haematology, Department of Paediatrics, St Mary's Hospital, Paddington, London, UK.

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http://dx.doi.org/10.1111/j.1365-2141.2005.05809.xDOI Listing
January 2006

Regulation of hematopoiesis in vitro and in vivo by invariant NKT cells.

Blood 2006 Apr 22;107(8):3138-44. Epub 2005 Dec 22.

Department of Haematology, Imperial College London, Hammersmith Hospital, Du Cane Rd, London W12 0NN, United Kingdom.

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http://dx.doi.org/10.1182/blood-2005-07-2804DOI Listing
April 2006

The role of mesenchymal stem cells in haemopoiesis.

Blood Rev 2006 May 20;20(3):161-71. Epub 2005 Dec 20.

Department of Immunology, Faculty of Medicine, Hammersmith Campus, Imperial College London, Du Cane Road, London, UK.

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http://dx.doi.org/10.1016/j.blre.2005.11.002DOI Listing
May 2006

Red blood cell transfusion in neonates.

Pediatrics 2005 Dec;116(6):1609; author reply 1609-10

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http://pediatrics.aappublications.org/cgi/doi/10.1542/peds.2
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http://dx.doi.org/10.1542/peds.2005-1593DOI Listing
December 2005

Human invariant NKT cells are required for effective in vitro alloresponses.

J Immunol 2005 Oct;175(8):5087-94

Department of Haematology, Imperial College London, Hammersmith Hospital, London, United Kingdom.

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http://dx.doi.org/10.4049/jimmunol.175.8.5087DOI Listing
October 2005

Bone involvement in sickle cell disease.

Br J Haematol 2005 May;129(4):482-90

Department of Haematology, Imperial College London, Hammersmith Hospital, Du Cane Road, London, UK.

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http://doi.wiley.com/10.1111/j.1365-2141.2005.05476.x
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http://dx.doi.org/10.1111/j.1365-2141.2005.05476.xDOI Listing
May 2005

Neonatal thrombocytopenia.

Early Hum Dev 2005 Jan 19;81(1):35-41. Epub 2004 Nov 19.

Department of Haematology, Great Ormond Street Hospital, Great Ormond Street, London WC1N 3JH, UK.

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https://www.researchgate.net/profile/Enrico_Lopriore/publica
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http://hospital.blood.co.uk/media/27281/inf272v14.pdf
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http://linkinghub.elsevier.com/retrieve/pii/S037837820400185
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http://dx.doi.org/10.1016/j.earlhumdev.2004.10.013DOI Listing
January 2005

GATA1 mutation and trisomy 21 are required only in haematopoietic cells for development of transient myeloproliferative disorder.

Br J Haematol 2005 Feb;128(4):548-51

Department of Haematology and MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, Oxford Radcliffe Hospital, Oxford OX3 9DU, UK.

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http://dx.doi.org/10.1111/j.1365-2141.2004.05342.xDOI Listing
February 2005

Regulatory and compliance activities to protect food-allergic consumers in Canada: research in support of standard setting and consumer protection.

J AOAC Int 2004 Nov-Dec;87(6):1408-16

Bureau of Chemical Safety, Food Directorate, Health Products and Food Branch, Health Canada, Ottawa, Ontario, Canada, K1A 0L2.

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June 2005

Human fetal mesenchymal stem cells as vehicles for gene delivery.

Stem Cells 2005 ;23(1):93-102

Institute of Reproductive and Developmental Biology & Queen Charlote's and Chelsea Hospital, Imperial College London, Du Cane Road, London W12 0NN, UK.

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http://doi.wiley.com/10.1634/stemcells.2004-0138
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http://dx.doi.org/10.1634/stemcells.2004-0138DOI Listing
June 2005

Microchimerism in female bone marrow and bone decades after fetal mesenchymal stem-cell trafficking in pregnancy.

Lancet 2004 Jul 10-16;364(9429):179-82

Institute of Reproductive and Developmental Biology, Division of Paediatrics, Obstetrics and Gynaecology, Imperial College London, Hammersmith Campus, London W12 0NN, UK.

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http://dx.doi.org/10.1016/S0140-6736(04)16631-2DOI Listing
July 2004

Natural history of GATA1 mutations in Down syndrome.

Blood 2004 Apr 4;103(7):2480-9. Epub 2003 Dec 4.

Department of Hematology, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford OX3 9DU, UK.

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http://dx.doi.org/10.1182/blood-2003-10-3383DOI Listing
April 2004