Irene M Ghobrial

Irene M Ghobrial

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Irene M Ghobrial

Irene M Ghobrial

Publications by authors named "Irene M Ghobrial"

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Reply to F.D. Leonard.

J Clin Oncol 2019 Oct 19;37(29):2701-2702. Epub 2019 Aug 19.

Mark Bustoros, MD; Romanos Sklavenitis-Pistofidis, MD; Jorge J. Castillo, MD; Steven P. Treon, MD, PhD; and Irene M. Ghobrial, MD, Dana-Farber Cancer Institute, Boston, MA.

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http://dx.doi.org/10.1200/JCO.19.01708DOI Listing
October 2019

A Phase Ib/II Study of Oprozomib in Patients with Advanced Multiple Myeloma and Waldenström Macroglobulinemia.

Clin Cancer Res 2019 Aug 29;25(16):4907-4916. Epub 2019 May 29.

Myeloma Research, Sarah Cannon Research Institute, Nashville, Tennessee.

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http://dx.doi.org/10.1158/1078-0432.CCR-18-3728DOI Listing
August 2019

Monoclonal gammopathy of undetermined significance.

Blood 2019 Jun 22;133(23):2484-2494. Epub 2019 Apr 22.

The Center for Prevention of Progression of Blood Cancers, Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA.

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http://www.bloodjournal.org/lookup/doi/10.1182/blood.2019846
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http://dx.doi.org/10.1182/blood.2019846782DOI Listing
June 2019

Dietary Pattern and Risk of Multiple Myeloma in Two Large Prospective US Cohort Studies.

JNCI Cancer Spectr 2019 Jun 27;3(2):pkz025. Epub 2019 Apr 27.

Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.

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http://dx.doi.org/10.1093/jncics/pkz025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6532330PMC
June 2019

Immunotherapy for hematological malignancies.

J Life Sci (Westlake Village) 2019 Jun;1(1):46-52

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA Harvard Institute of Medicine Room 237, 4 Blackfan Circle, Boston MA 02115.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6709701PMC
June 2019

Acute lymphoblastic leukemia as a clonally unrelated second primary malignancy after multiple myeloma.

Leukemia 2019 01 19;33(1):266-270. Epub 2018 Jul 19.

The Judy and Bernard Briskin Center for Multiple Myeloma Research, City of Hope, Duarte, CA, USA.

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http://dx.doi.org/10.1038/s41375-018-0213-yDOI Listing
January 2019

Autologous graft versus myeloma: it's not a myth.

J Clin Invest 2019 Jan 19;129(1):48-50. Epub 2018 Nov 19.

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http://dx.doi.org/10.1172/JCI125431DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307964PMC
January 2019

Multiple Myeloma and the Immune Microenvironment.

Curr Cancer Drug Targets 2017 ;17(9):806-818

Transplantation Research Center, Renal Division, Brigham and Women's Hospital and Children's Hospital, 221 Longwood Ave, Boston, MA 02115. United States.

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http://dx.doi.org/10.2174/1568009617666170214102301DOI Listing
June 2018

Current use of monoclonal antibodies in the treatment of multiple myeloma.

Br J Haematol 2018 05 25;181(4):447-459. Epub 2018 Apr 25.

Dana Farber Cancer Institute, Harvard Medical School, Jerome Lipper Multiple Myeloma Center, Boston, MA, USA.

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http://dx.doi.org/10.1111/bjh.15121DOI Listing
May 2018

The role of miRNAs in plasma cell dyscrasias.

Microrna 2014 ;2(3):165-73

Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.

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April 2018

The bone-marrow niche in MDS and MGUS: implications for AML and MM.

Nat Rev Clin Oncol 2018 04 9;15(4):219-233. Epub 2018 Jan 9.

Division of Hematological Malignancies, Department of Medical Oncology, Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1038/nrclinonc.2017.197DOI Listing
April 2018

Exosomes in Tumor Angiogenesis.

Methods Mol Biol 2016 ;1464:25-34

Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1007/978-1-4939-3999-2_3DOI Listing
January 2018

Established and Novel Prognostic Biomarkers in Multiple Myeloma.

Am Soc Clin Oncol Educ Book 2017 ;37:548-560

From the Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA.

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http://dx.doi.org/10.1200/EDBK_175175DOI Listing
December 2017

Genomic Aberrations in Multiple Myeloma.

Cancer Treat Res 2016;169:23-34

Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, USA.

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http://dx.doi.org/10.1007/978-3-319-40320-5_3DOI Listing
June 2017

Epigenetics in Multiple Myeloma.

Cancer Treat Res 2016;169:35-49

Harvard Medical School, Dana-Farber Cancer Institute, Boston, MA, USA.

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http://dx.doi.org/10.1007/978-3-319-40320-5_4DOI Listing
June 2017

Serum IgM level as predictor of symptomatic hyperviscosity in patients with Waldenström macroglobulinaemia.

Br J Haematol 2017 06 9;177(5):717-725. Epub 2017 May 9.

Bing Center for Waldenström Macroglobulinemia, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1111/bjh.14743DOI Listing
June 2017

Prospective, Multicenter Clinical Trial of Everolimus as Primary Therapy in Waldenstrom Macroglobulinemia (WMCTG 09-214).

Clin Cancer Res 2017 May 11;23(10):2400-2404. Epub 2016 Nov 11.

Bing Center for Waldenstrom's Macroglobulinemia at the Dana-Farber Cancer Institute; and Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1158/1078-0432.CCR-16-1918DOI Listing
May 2017

Genomic complexity of multiple myeloma and its clinical implications.

Nat Rev Clin Oncol 2017 02 17;14(2):100-113. Epub 2016 Aug 17.

Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, HIM 237, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1038/nrclinonc.2016.122DOI Listing
February 2017

Future Directions in the Evaluation and Treatment of Precursor Plasma Cell Disorders.

Am Soc Clin Oncol Educ Book 2016 ;35:e400-6

From the Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA.

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http://dx.doi.org/10.1200/EDBK_159010DOI Listing
January 2017

Response to ibrutinib in a patient with IgG lymphoplasmacytic lymphoma carrying the MYD88 L265P gene mutation.

Leuk Lymphoma 2016 11 16;57(11):2699-701. Epub 2016 Mar 16.

a Division of Hematologic Malignancies , Dana-Farber Cancer Institute, Harvard Medical School , Boston , MA , USA.

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http://dx.doi.org/10.3109/10428194.2016.1157875DOI Listing
November 2016

Targeting SDF-1 in multiple myeloma tumor microenvironment.

Cancer Lett 2016 09 30;380(1):315-8. Epub 2015 Nov 30.

Dana-Farber Cancer Institute, Department of Medical Oncology, Harvard Medical School, 450 Brookline Avenue, HIM 246, Boston, MA 02215, USA. Electronic address:

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http://dx.doi.org/10.1016/j.canlet.2015.11.028DOI Listing
September 2016

Myeloma Cell Dynamics in Response to Treatment Supports a Model of Hierarchical Differentiation and Clonal Evolution.

Clin Cancer Res 2016 Aug 22;22(16):4206-4214. Epub 2016 Mar 22.

Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, and Department of Biostatistics, Harvard T. H. Chan School of Public Health, Boston, MA 02115, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-15-2793DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4987182PMC
August 2016

Cell autonomous and microenvironmental regulation of tumor progression in precursor states of multiple myeloma.

Curr Opin Hematol 2016 07;23(4):426-33

aMedical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, USA *Aldo M. Roccaro and Irene M. Ghobrial are co-senior authors.

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http://dx.doi.org/10.1097/MOH.0000000000000259DOI Listing
July 2016

Epigenomics in Waldenstrom's macroglobulinaemia.

Best Pract Res Clin Haematol 2016 06 25;29(2):156-160. Epub 2016 Sep 25.

ASST Spedali Civili, Department of Medical Oncology, CREA Laboratory, Brescia, Italy; Dana-Farber Cancer Institute, Department of Medical Oncology, Boston, MA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.beha.2016.08.022DOI Listing
June 2016

Cancer Cell Dissemination and Homing to the Bone Marrow in a Zebrafish Model.

Cancer Res 2016 Jan 7;76(2):463-71. Epub 2016 Jan 7.

Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1158/0008-5472.CAN-15-1926DOI Listing
January 2016

Global epigenetic regulation of microRNAs in multiple myeloma.

PLoS One 2014 17;9(10):e110973. Epub 2014 Oct 17.

Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0110973PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4201574PMC
December 2015

Clinical perspective: Linking psychosocial care to the disease continuum in patients with multiple myeloma.

Palliat Support Care 2015 Aug 24;13(4):829-38. Epub 2014 Jun 24.

Dana-Farber Cancer Institute, Harvard Medical School,Boston,Massachusetts.

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http://dx.doi.org/10.1017/S1478951514000649DOI Listing
August 2015

The cancer glycome: carbohydrates as mediators of metastasis.

Blood Rev 2015 Jul 23;29(4):269-79. Epub 2015 Jan 23.

Glycoscience Research Group, National University of Ireland, Galway, Ireland; Department of Hematology National University of Ireland, Galway and Galway University Hospital, Ireland. Electronic address:

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http://dx.doi.org/10.1016/j.blre.2015.01.003DOI Listing
July 2015

Cyclophosphamide, bortezomib, and dexamethasone combination in waldenstrom macroglobulinemia.

Am J Hematol 2015 Jun 10;90(6):E122-3. Epub 2015 May 10.

Harvard Medical School, Dana-Farber Cancer Institute, Boston, Massachusetts.

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http://dx.doi.org/10.1002/ajh.23985DOI Listing
June 2015

Dynamic interplay between bone and multiple myeloma: emerging roles of the osteoblast.

Bone 2015 Jun 26;75:161-9. Epub 2015 Feb 26.

Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bone.2015.02.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4580250PMC
June 2015

American Society of Hematology Annual Meeting 2014: highlights in multiple myeloma.

Expert Rev Hematol 2015 Jun 24;8(3):273-5. Epub 2015 Mar 24.

Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1586/17474086.2015.1029449DOI Listing
June 2015

Metabolic signature identifies novel targets for drug resistance in multiple myeloma.

Cancer Res 2015 May 13;75(10):2071-82. Epub 2015 Mar 13.

Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1158/0008-5472.CAN-14-3400DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4433568PMC
May 2015

Biology, prognosis, and therapy of Waldenström Macroglobulinemia.

Cancer Treat Res 2015 ;165:177-95

Division of Hematologic Malignancies, Dana-Farber Cancer Institute, Harvard Medical School, 450 Brookline Ave, M221, 02215, Boston, MA, USA,

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http://dx.doi.org/10.1007/978-3-319-13150-4_7DOI Listing
April 2015

Hypoxia promotes dissemination and colonization in new bone marrow niches in Waldenström macroglobulinemia.

Mol Cancer Res 2015 Feb 17;13(2):263-72. Epub 2014 Sep 17.

Department of Radiation Oncology, Cancer Biology Division, Washington University in Saint Louis School of Medicine, Saint Louis, Missouri.

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http://mcr.aacrjournals.org/lookup/doi/10.1158/1541-7786.MCR
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http://dx.doi.org/10.1158/1541-7786.MCR-14-0150DOI Listing
February 2015

Extramedullary Waldenström macroglobulinemia.

Am J Hematol 2015 Feb 19;90(2):100-4. Epub 2014 Nov 19.

Medical Oncology, Dana-Farber Cancer Institute, and Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1002/ajh.23880DOI Listing
February 2015

Targeting the bone marrow microenvironment in multiple myeloma.

Immunol Rev 2015 Jan;263(1):160-72

Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1111/imr.12233DOI Listing
January 2015

Team work matters: dual inhibition puts non-hodgkin lymphoma under siege.

Clin Cancer Res 2014 Dec 7;20(23):5863-5. Epub 2014 Oct 7.

Dana-Farber Cancer Institute, Department of Medical Oncology, Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1158/1078-0432.CCR-14-2055DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4433012PMC
December 2014

How I treat smoldering multiple myeloma.

Blood 2014 Nov 8;124(23):3380-8. Epub 2014 Oct 8.

Memorial Sloan Kettering Cancer Center, New York, NY.

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http://dx.doi.org/10.1182/blood-2014-08-551549DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4246036PMC
November 2014

Altered cytokine and chemokine profiles in multiple myeloma and its precursor disease.

Cytokine 2014 Oct 17;69(2):294-7. Epub 2014 Jul 17.

Lymphoid Malignancies Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA; Myeloma Service, Memorial Sloan-Kettering Cancer Center, New York, NY, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cyto.2014.05.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4148078PMC
October 2014

The sialyltransferase ST3GAL6 influences homing and survival in multiple myeloma.

Blood 2014 Sep 24;124(11):1765-76. Epub 2014 Jul 24.

Department of Hematology, National University of Ireland, Galway and Galway University Hospital, Galway, Ireland; Glycoscience Research Group, National University of Ireland, Galway, Ireland.

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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2014-03-56
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http://dx.doi.org/10.1182/blood-2014-03-560862DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4162107PMC
September 2014

Role of endothelial progenitor cells in cancer progression.

Biochim Biophys Acta 2014 Aug 4;1846(1):26-39. Epub 2014 Apr 4.

Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bbcan.2014.03.005DOI Listing
August 2014

Biomarkers of bone remodeling in multiple myeloma patients to tailor bisphosphonate therapy.

Clin Cancer Res 2014 Aug 23;20(15):3955-61. Epub 2014 Jun 23.

Massachusetts General Hospital Cancer Center; Harvard Medical School, Boston, Massachusetts

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http://dx.doi.org/10.1158/1078-0432.CCR-14-0434DOI Listing
August 2014

Regulation of microRNAs in cancer metastasis.

Biochim Biophys Acta 2014 Apr 22;1845(2):255-65. Epub 2014 Feb 22.

Dana-Farber Cancer Institute, Department of Medical Oncology, Harvard Medical School, 450 Brookline Avenue, HIM 246, Boston, MA 02215, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bbcan.2014.02.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4170185PMC
April 2014

miR-630 targets IGF1R to regulate response to HER-targeting drugs and overall cancer cell progression in HER2 over-expressing breast cancer.

Mol Cancer 2014 Mar 24;13:71. Epub 2014 Mar 24.

School of Pharmacy and Pharmaceutical Sciences & Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland.

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http://dx.doi.org/10.1186/1476-4598-13-71DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4234346PMC
March 2014

Waldenström macroglobulinemia: from biology to treatment.

Expert Rev Hematol 2014 Feb 3;7(1):157-68. Epub 2014 Jan 3.

Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1586/17474086.2014.871494DOI Listing
February 2014

microRNA aberrations and their role in supporting hematologic malignancies.

Microrna 2014;2(3):157

Dana-Farber Cancer Institute Harvard Medical School 450 Brookline Av. HIM Building H246 02215, Boston, MA, USA.

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January 2014

Biological and Clinical Implications of Clonal Heterogeneity and Clonal Evolution in Multiple Myeloma.

Curr Cancer Ther Rev 2014;10(2):70-79

Dana-Farber Cancer Institute, Department of Medical Oncology, Harvard Medical School, 450 Brookline Avenue, Boston, MA 02215, USA.

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http://dx.doi.org/10.2174/157339471002141124121404DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4334389PMC
January 2014

Revisiting treatment paradigms in high-risk smoldering multiple myeloma: out with the old, in with the new?

Authors:
Irene M Ghobrial

Leuk Lymphoma 2013 Oct 2;54(10):2328-30. Epub 2013 May 2.

Dana-Farber Cancer Institute , Boston, MA , USA.

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http://dx.doi.org/10.3109/10428194.2013.788699DOI Listing
October 2013

The bone marrow microenvironment in Waldenström macroglobulinemia.

Clin Lymphoma Myeloma Leuk 2013 Apr 13;13(2):218-21. Epub 2013 Mar 13.

Division of Hematology/Oncology, University of Arizona, Tucson, AZ, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S21522650130001
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http://dx.doi.org/10.1016/j.clml.2013.02.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3654400PMC
April 2013

Update on Waldenström's macroglobulinemia.

Authors:
Irene M Ghobrial

Clin Adv Hematol Oncol 2013 Apr;11(4):244-6

Harvard Medical School, Boston, MA, USA.

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April 2013