Publications by authors named "Irene M Ghobrial"

100Publications

Pregnancy outcomes, risk factors, and cell count trends in pregnant women with essential thrombocythemia.

Leuk Res 2020 Sep 29;98:106459. Epub 2020 Sep 29.

Department of Medical Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114, USA. Electronic address:

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http://dx.doi.org/10.1016/j.leukres.2020.106459DOI Listing
September 2020

Genome instability in multiple myeloma.

Leukemia 2020 Nov 10;34(11):2887-2897. Epub 2020 Jul 10.

Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1038/s41375-020-0921-yDOI Listing
November 2020

Monoclonal Gammopathy of Undetermined Significance (MGUS)-Not So Asymptomatic after All.

Cancers (Basel) 2020 Jun 12;12(6). Epub 2020 Jun 12.

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.

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http://dx.doi.org/10.3390/cancers12061554DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7352603PMC
June 2020

Intensification and consolidation therapy in multiple myeloma in the current era.

Lancet Haematol 2020 06 30;7(6):e427-e429. Epub 2020 Apr 30.

Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA.

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http://dx.doi.org/10.1016/S2352-3026(20)30110-1DOI Listing
June 2020

Clinical Controversies in the Management of Smoldering Multiple Myeloma.

Am Soc Clin Oncol Educ Book 2020 Mar;40:1-6

Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA.

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http://dx.doi.org/10.1200/EDBK_278911DOI Listing
March 2020

Bone marrow niches in haematological malignancies.

Nat Rev Cancer 2020 05 28;20(5):285-298. Epub 2020 Feb 28.

Georg-Speyer-Haus, Institute for Tumor Biology and Experimental Medicine, Frankfurt, Germany.

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http://dx.doi.org/10.1038/s41568-020-0245-2DOI Listing
May 2020

Prediagnosis dietary pattern and survival in patients with multiple myeloma.

Int J Cancer 2020 Oct 28;147(7):1823-1830. Epub 2020 Feb 28.

Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.

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http://dx.doi.org/10.1002/ijc.32928DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7423719PMC
October 2020

Dissecting racial disparities in multiple myeloma.

Blood Cancer J 2020 02 17;10(2):19. Epub 2020 Feb 17.

Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA, 02215, USA.

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http://dx.doi.org/10.1038/s41408-020-0284-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7026439PMC
February 2020

The microenvironment in myeloma.

Curr Opin Oncol 2020 03;32(2):170-175

Dana-Farber Cancer Institute, Boston.

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http://dx.doi.org/10.1097/CCO.0000000000000615DOI Listing
March 2020

Antibody-targeting of ultra-small nanoparticles enhances imaging sensitivity and enables longitudinal tracking of multiple myeloma.

Nanoscale 2019 Nov 25;11(43):20485-20496. Epub 2019 Oct 25.

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA. and Harvard Medical School, 25 Shattuck Street, Boston, MA 02115, USA and David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.

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http://dx.doi.org/10.1039/c9nr06512aDOI Listing
November 2019

Immunotherapy for hematological malignancies.

J Life Sci (Westlake Village) 2019 Jun;1(1):46-52

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA Harvard Institute of Medicine Room 237, 4 Blackfan Circle, Boston MA 02115.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6709701PMC
June 2019

Reply to F.D. Leonard.

J Clin Oncol 2019 10 19;37(29):2701-2702. Epub 2019 Aug 19.

Mark Bustoros, MD; Romanos Sklavenitis-Pistofidis, MD; Jorge J. Castillo, MD; Steven P. Treon, MD, PhD; and Irene M. Ghobrial, MD, Dana-Farber Cancer Institute, Boston, MA.

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http://dx.doi.org/10.1200/JCO.19.01708DOI Listing
October 2019

Dietary Pattern and Risk of Multiple Myeloma in Two Large Prospective US Cohort Studies.

JNCI Cancer Spectr 2019 Jun 27;3(2):pkz025. Epub 2019 Apr 27.

Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.

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http://dx.doi.org/10.1093/jncics/pkz025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6532330PMC
June 2019

A Phase Ib/II Study of Oprozomib in Patients with Advanced Multiple Myeloma and Waldenström Macroglobulinemia.

Clin Cancer Res 2019 08 29;25(16):4907-4916. Epub 2019 May 29.

Myeloma Research, Sarah Cannon Research Institute, Nashville, Tennessee.

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http://dx.doi.org/10.1158/1078-0432.CCR-18-3728DOI Listing
August 2019

Monoclonal gammopathy of undetermined significance.

Blood 2019 06 22;133(23):2484-2494. Epub 2019 Apr 22.

The Center for Prevention of Progression of Blood Cancers, Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA.

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http://www.bloodjournal.org/lookup/doi/10.1182/blood.2019846
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http://dx.doi.org/10.1182/blood.2019846782DOI Listing
June 2019

Autologous graft versus myeloma: it's not a myth.

J Clin Invest 2019 01 19;129(1):48-50. Epub 2018 Nov 19.

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http://dx.doi.org/10.1172/JCI125431DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307964PMC
January 2019

Acute lymphoblastic leukemia as a clonally unrelated second primary malignancy after multiple myeloma.

Leukemia 2019 01 19;33(1):266-270. Epub 2018 Jul 19.

The Judy and Bernard Briskin Center for Multiple Myeloma Research, City of Hope, Duarte, CA, USA.

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http://dx.doi.org/10.1038/s41375-018-0213-yDOI Listing
January 2019

Current use of monoclonal antibodies in the treatment of multiple myeloma.

Br J Haematol 2018 05 25;181(4):447-459. Epub 2018 Apr 25.

Dana Farber Cancer Institute, Harvard Medical School, Jerome Lipper Multiple Myeloma Center, Boston, MA, USA.

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http://dx.doi.org/10.1111/bjh.15121DOI Listing
May 2018

The bone-marrow niche in MDS and MGUS: implications for AML and MM.

Nat Rev Clin Oncol 2018 04 9;15(4):219-233. Epub 2018 Jan 9.

Division of Hematological Malignancies, Department of Medical Oncology, Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1038/nrclinonc.2017.197DOI Listing
April 2018

Established and Novel Prognostic Biomarkers in Multiple Myeloma.

Am Soc Clin Oncol Educ Book 2017 ;37:548-560

From the Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA.

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http://dx.doi.org/10.1200/EDBK_175175DOI Listing
December 2017

Serum IgM level as predictor of symptomatic hyperviscosity in patients with Waldenström macroglobulinaemia.

Br J Haematol 2017 06 9;177(5):717-725. Epub 2017 May 9.

Bing Center for Waldenström Macroglobulinemia, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1111/bjh.14743DOI Listing
June 2017

Multiple Myeloma and the Immune Microenvironment.

Curr Cancer Drug Targets 2017 ;17(9):806-818

Transplantation Research Center, Renal Division, Brigham and Women's Hospital and Children's Hospital, 221 Longwood Ave, Boston, MA 02115. United States.

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http://dx.doi.org/10.2174/1568009617666170214102301DOI Listing
June 2018

Exosomes in Tumor Angiogenesis.

Methods Mol Biol 2016 ;1464:25-34

Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1007/978-1-4939-3999-2_3DOI Listing
January 2018

Prospective, Multicenter Clinical Trial of Everolimus as Primary Therapy in Waldenstrom Macroglobulinemia (WMCTG 09-214).

Clin Cancer Res 2017 May 11;23(10):2400-2404. Epub 2016 Nov 11.

Bing Center for Waldenstrom's Macroglobulinemia at the Dana-Farber Cancer Institute; and Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1158/1078-0432.CCR-16-1918DOI Listing
May 2017

Epigenomics in Waldenstrom's macroglobulinaemia.

Best Pract Res Clin Haematol 2016 06 25;29(2):156-160. Epub 2016 Sep 25.

ASST Spedali Civili, Department of Medical Oncology, CREA Laboratory, Brescia, Italy; Dana-Farber Cancer Institute, Department of Medical Oncology, Boston, MA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.beha.2016.08.022DOI Listing
June 2016

Genomic complexity of multiple myeloma and its clinical implications.

Nat Rev Clin Oncol 2017 02 17;14(2):100-113. Epub 2016 Aug 17.

Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, HIM 237, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1038/nrclinonc.2016.122DOI Listing
February 2017

Epigenetics in Multiple Myeloma.

Cancer Treat Res 2016;169:35-49

Harvard Medical School, Dana-Farber Cancer Institute, Boston, MA, USA.

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http://dx.doi.org/10.1007/978-3-319-40320-5_4DOI Listing
June 2017

Genomic Aberrations in Multiple Myeloma.

Cancer Treat Res 2016;169:23-34

Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, USA.

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http://dx.doi.org/10.1007/978-3-319-40320-5_3DOI Listing
June 2017

Future Directions in the Evaluation and Treatment of Precursor Plasma Cell Disorders.

Am Soc Clin Oncol Educ Book 2016 ;35:e400-6

From the Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA.

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http://dx.doi.org/10.1200/EDBK_159010DOI Listing
January 2017

Cell autonomous and microenvironmental regulation of tumor progression in precursor states of multiple myeloma.

Curr Opin Hematol 2016 07;23(4):426-33

aMedical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, USA *Aldo M. Roccaro and Irene M. Ghobrial are co-senior authors.

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http://dx.doi.org/10.1097/MOH.0000000000000259DOI Listing
July 2016

Myeloma Cell Dynamics in Response to Treatment Supports a Model of Hierarchical Differentiation and Clonal Evolution.

Clin Cancer Res 2016 Aug 22;22(16):4206-4214. Epub 2016 Mar 22.

Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, and Department of Biostatistics, Harvard T. H. Chan School of Public Health, Boston, MA 02115, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-15-2793DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4987182PMC
August 2016

Response to ibrutinib in a patient with IgG lymphoplasmacytic lymphoma carrying the MYD88 L265P gene mutation.

Leuk Lymphoma 2016 11 16;57(11):2699-701. Epub 2016 Mar 16.

a Division of Hematologic Malignancies , Dana-Farber Cancer Institute, Harvard Medical School , Boston , MA , USA.

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http://dx.doi.org/10.3109/10428194.2016.1157875DOI Listing
November 2016

Cancer Cell Dissemination and Homing to the Bone Marrow in a Zebrafish Model.

Cancer Res 2016 Jan 7;76(2):463-71. Epub 2016 Jan 7.

Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1158/0008-5472.CAN-15-1926DOI Listing
January 2016

Targeting SDF-1 in multiple myeloma tumor microenvironment.

Cancer Lett 2016 09 30;380(1):315-8. Epub 2015 Nov 30.

Dana-Farber Cancer Institute, Department of Medical Oncology, Harvard Medical School, 450 Brookline Avenue, HIM 246, Boston, MA 02215, USA. Electronic address:

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http://dx.doi.org/10.1016/j.canlet.2015.11.028DOI Listing
September 2016

American Society of Hematology Annual Meeting 2014: highlights in multiple myeloma.

Expert Rev Hematol 2015 Jun 24;8(3):273-5. Epub 2015 Mar 24.

Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1586/17474086.2015.1029449DOI Listing
June 2015

Metabolic signature identifies novel targets for drug resistance in multiple myeloma.

Cancer Res 2015 May 13;75(10):2071-82. Epub 2015 Mar 13.

Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1158/0008-5472.CAN-14-3400DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4433568PMC
May 2015

Dynamic interplay between bone and multiple myeloma: emerging roles of the osteoblast.

Bone 2015 Jun 26;75:161-9. Epub 2015 Feb 26.

Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bone.2015.02.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4580250PMC
June 2015

Biological and Clinical Implications of Clonal Heterogeneity and Clonal Evolution in Multiple Myeloma.

Curr Cancer Ther Rev 2014;10(2):70-79

Dana-Farber Cancer Institute, Department of Medical Oncology, Harvard Medical School, 450 Brookline Avenue, Boston, MA 02215, USA.

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http://dx.doi.org/10.2174/157339471002141124121404DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4334389PMC
January 2014

Cyclophosphamide, bortezomib, and dexamethasone combination in waldenstrom macroglobulinemia.

Am J Hematol 2015 Jun 10;90(6):E122-3. Epub 2015 May 10.

Harvard Medical School, Dana-Farber Cancer Institute, Boston, Massachusetts.

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http://dx.doi.org/10.1002/ajh.23985DOI Listing
June 2015

Biology, prognosis, and therapy of Waldenström Macroglobulinemia.

Cancer Treat Res 2015 ;165:177-95

Division of Hematologic Malignancies, Dana-Farber Cancer Institute, Harvard Medical School, 450 Brookline Ave, M221, 02215, Boston, MA, USA,

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http://dx.doi.org/10.1007/978-3-319-13150-4_7DOI Listing
April 2015

The cancer glycome: carbohydrates as mediators of metastasis.

Blood Rev 2015 Jul 23;29(4):269-79. Epub 2015 Jan 23.

Glycoscience Research Group, National University of Ireland, Galway, Ireland; Department of Hematology National University of Ireland, Galway and Galway University Hospital, Ireland. Electronic address:

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http://dx.doi.org/10.1016/j.blre.2015.01.003DOI Listing
July 2015

Targeting the bone marrow microenvironment in multiple myeloma.

Immunol Rev 2015 Jan;263(1):160-72

Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1111/imr.12233DOI Listing
January 2015

Extramedullary Waldenström macroglobulinemia.

Am J Hematol 2015 Feb 19;90(2):100-4. Epub 2014 Nov 19.

Medical Oncology, Dana-Farber Cancer Institute, and Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1002/ajh.23880DOI Listing
February 2015

Global epigenetic regulation of microRNAs in multiple myeloma.

PLoS One 2014 17;9(10):e110973. Epub 2014 Oct 17.

Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0110973PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4201574PMC
December 2015

How I treat smoldering multiple myeloma.

Blood 2014 Nov 8;124(23):3380-8. Epub 2014 Oct 8.

Memorial Sloan Kettering Cancer Center, New York, NY.

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http://dx.doi.org/10.1182/blood-2014-08-551549DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4246036PMC
November 2014

Team work matters: dual inhibition puts non-hodgkin lymphoma under siege.

Clin Cancer Res 2014 Dec 7;20(23):5863-5. Epub 2014 Oct 7.

Dana-Farber Cancer Institute, Department of Medical Oncology, Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1158/1078-0432.CCR-14-2055DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4433012PMC
December 2014

Hypoxia promotes dissemination and colonization in new bone marrow niches in Waldenström macroglobulinemia.

Mol Cancer Res 2015 Feb 17;13(2):263-72. Epub 2014 Sep 17.

Department of Radiation Oncology, Cancer Biology Division, Washington University in Saint Louis School of Medicine, Saint Louis, Missouri.

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http://mcr.aacrjournals.org/lookup/doi/10.1158/1541-7786.MCR
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http://dx.doi.org/10.1158/1541-7786.MCR-14-0150DOI Listing
February 2015

The role of miRNAs in plasma cell dyscrasias.

Microrna 2014 ;2(3):165-73

Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.2174/2211536602666131126002144DOI Listing
April 2018

microRNA aberrations and their role in supporting hematologic malignancies.

Microrna 2014;2(3):157

Dana-Farber Cancer Institute Harvard Medical School 450 Brookline Av. HIM Building H246 02215, Boston, MA, USA.

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http://dx.doi.org/10.2174/221153660203140121105709DOI Listing
January 2014

The sialyltransferase ST3GAL6 influences homing and survival in multiple myeloma.

Blood 2014 Sep 24;124(11):1765-76. Epub 2014 Jul 24.

Department of Hematology, National University of Ireland, Galway and Galway University Hospital, Galway, Ireland; Glycoscience Research Group, National University of Ireland, Galway, Ireland.

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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2014-03-56
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http://dx.doi.org/10.1182/blood-2014-03-560862DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4162107PMC
September 2014

Altered cytokine and chemokine profiles in multiple myeloma and its precursor disease.

Cytokine 2014 Oct 17;69(2):294-7. Epub 2014 Jul 17.

Lymphoid Malignancies Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA; Myeloma Service, Memorial Sloan-Kettering Cancer Center, New York, NY, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cyto.2014.05.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4148078PMC
October 2014