Irene Knuesel

Division of Pharmacy and Optometry, School of Health Sciences, Faculty of Medicine, Biology and Health, University of Manchester, Manchester M13 9PT, United Kingdom. Electronic address:

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January 2019

An In Vitro Bone Model to Investigate the Role of Triggering Receptor Expressed on Myeloid Cells-2 in Bone Homeostasis.

Authors:

Eleonora Rossi Eva Mracsko Adam Papadimitropoulos Nima Allafi Dieter Reinhardt Arne Mehrkens Ivan Martin Irene Knuesel Arnaud Scherberich

Tissue Eng Part C Methods 2018 07;24(7):391-398

1 Department of Biomedicine, University Hospital of Basel, University of Basel , Basel, Switzerland .

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July 2018

NF-κB activation in astrocytes drives a stage-specific beneficial neuroimmunological response in ALS.

EMBO J 2018 08 6;37(16). Epub 2018 Jun 6.

Institute of Physiological Chemistry, Ulm University, Ulm, Germany

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August 2018

Contribution of early Alzheimer's disease-related pathophysiology to the development of acquired epilepsy.

Authors:

Tilo Gschwind Carlos Lafourcade Tim Gfeller Mariana Zaichuk Lukas Rambousek Irene Knuesel Jean-Marc Fritschy

Eur J Neurosci 2018 06 19;47(12):1534-1562. Epub 2018 Jun 19.

Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland.

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June 2018

The FTD-like syndrome causing TREM2 T66M mutation impairs microglia function, brain perfusion, and glucose metabolism.

EMBO J 2017 07 30;36(13):1837-1853. Epub 2017 May 30.

Biomedical Center (BMC), Biochemistry, Ludwig-Maximilians-Universität München, Munich, Germany

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July 2017

TREM2 deficiency reduces the efficacy of immunotherapeutic amyloid clearance.

Authors:

Xianyuan Xiang Georg Werner Bernd Bohrmann Arthur Liesz Fargol Mazaheri Anja Capell Regina Feederle Irene Knuesel Gernot Kleinberger Christian Haass

EMBO Mol Med 2016 09 1;8(9):992-1004. Epub 2016 Sep 1.

Biomedical Center (BMC), Biochemistry, Ludwig-Maximilians-University Munich, Munich, Germany Munich Cluster for Systems Neurology (SyNergy), Munich, Germany German Center for Neurodegenerative Diseases (DZNE) Munich, Munich, Germany

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September 2016

Maternal immune activation and abnormal brain development across CNS disorders.

Authors:

Irene Knuesel Laurie Chicha Markus Britschgi Scott A Schobel Michael Bodmer Jessica A Hellings Stephen Toovey Eric P Prinssen

Nat Rev Neurol 2014 Nov 14;10(11):643-60. Epub 2014 Oct 14.

Roche Pharma Research and Early Development, Roche Innovation Centre Basel, Grenzacherstrasse 124, 4070 Basel, Switzerland.

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November 2014

Novel role of cystic fibrosis transmembrane conductance regulator in maintaining adult mouse olfactory neuronal homeostasis.

Authors:

Sandra Pfister Tamara Weber Wolfgang Härtig Cornelia Schwerdel Rebecca Elsaesser Irene Knuesel Jean-Marc Fritschy

J Comp Neurol 2015 Feb 15;523(3):406-30. Epub 2014 Oct 15.

Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland; Neuroscience Center Zurich, University of Zurich and ETH Zurich, Zurich, Switzerland.

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February 2015

Reelin immunoreactivity in neuritic varicosities in the human hippocampal formation of non-demented subjects and Alzheimer's disease patients.

Authors:

Tina Notter Irene Knuesel

Acta Neuropathol Commun 2013 Jun 26;1:27. Epub 2013 Jun 26.

Institute of Pharmacology and Toxicology, University of Zurich, Winterthurerstrasse 190, Zurich, CH-8057, Switzerland.

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June 2013

The airbag problem-a potential culprit for bench-to-bedside translational efforts: relevance for Alzheimer's disease.

Authors:

Dimitrije Krstic Irene Knuesel

Acta Neuropathol Commun 2013 Sep 23;1:62. Epub 2013 Sep 23.

Institute of Pharmacology and Toxicology, University of Zurich, Zurich, CH-8057, Switzerland.

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September 2013

Longitudinal Assessment of Amyloid Pathology in Transgenic ArcAβ Mice Using Multi-Parametric Magnetic Resonance Imaging.

Authors:

Jan Klohs Igna Wojtyna Politano Andreas Deistung Joanes Grandjean Anna Drewek Marco Dominietto Ruth Keist Ferdinand Schweser Jürgen R Reichenbach Roger M Nitsch Irene Knuesel Markus Rudin

PLoS One 2013 19;8(6):e66097. Epub 2013 Jun 19.

Institute for Biomedical Engineering, ETH and University of Zurich, Zurich, Switzerland ; Neuroscience Center Zurich, University of Zurich and ETH Zurich, Zurich, Switzerland.

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October 2017

Deciphering the mechanism underlying late-onset Alzheimer disease.

Authors:

Dimitrije Krstic Irene Knuesel

Nat Rev Neurol 2013 Jan 27;9(1):25-34. Epub 2012 Nov 27.

Institute of Pharmacology and Toxicology, University of Zurich, Winterthurerstrasse 190, CH-8057, Zurich, Switzerland.

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January 2013

Regulated proteolytic processing of Reelin through interplay of tissue plasminogen activator (tPA), ADAMTS-4, ADAMTS-5, and their modulators.

Authors:

Dimitrije Krstic Myriam Rodriguez Irene Knuesel

PLoS One 2012 17;7(10):e47793. Epub 2012 Oct 17.

Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland.

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April 2013

Characterization and turnover of CD73/IP(3)R3-positive microvillar cells in the adult mouse olfactory epithelium.

Authors:

Sandra Pfister Maren G Dietrich Corinne Sidler Jean-Marc Fritschy Irene Knuesel Rebecca Elsaesser

Chem Senses 2012 Nov 5;37(9):859-68. Epub 2012 Sep 5.

Institute of Pharmacology and Toxicology, University of Zurich, Winterthurerstrasse 190, CH-8057 Zurich, Switzerland.

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November 2012

Systemic immune challenges trigger and drive Alzheimer-like neuropathology in mice.

Authors:

Dimitrije Krstic Amrita Madhusudan Jana Doehner Prisca Vogel Tina Notter Claudine Imhof Abigail Manalastas Martina Hilfiker Sandra Pfister Cornelia Schwerdel Carsten Riether Urs Meyer Irene Knuesel

J Neuroinflammation 2012 Jul 2;9:151. Epub 2012 Jul 2.

Institute of Pharmacology and Toxicology, University of Zurich, Winterthurerstrasse 190, CH-8057, Zurich, Switzerland.

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July 2012

Extrusion of misfolded and aggregated proteins--a protective strategy of aging neurons?

Authors:

Jana Doehner Christel Genoud Claudine Imhof Dimitrije Krstic Irene Knuesel

Eur J Neurosci 2012 Jun;35(12):1938-50

Institute of Pharmacology and Toxicology, University of Zurich, Winterthurerstrasse 190, Zurich, Switzerland.

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June 2012

Molecular and behavioral changes associated with adult hippocampus-specific SynGAP1 knockout.

Authors:

Mary Muhia Silvia Willadt Benjamin K Yee Joram Feldon Jean-Charles Paterna Severin Schwendener Kaspar Vogt Mary B Kennedy Irene Knuesel

Learn Mem 2012 Jun 14;19(7):268-81. Epub 2012 Jun 14.

Laboratory of Behavioral Neurobiology, Swiss Federal Institute of Technology, CH-8063 Schwerzenbach, Switzerland.

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June 2012

Impact of prenatal immune system disturbances on brain development.

Authors:

Amrita Madhusudan Prisca Vogel Irene Knuesel

J Neuroimmune Pharmacol 2013 Mar 13;8(1):79-86. Epub 2012 May 13.

Institute of Pharmacology and Toxicology, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland.

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March 2013

Contrast-enhanced magnetic resonance microangiography reveals remodeling of the cerebral microvasculature in transgenic ArcAβ mice.

Authors:

Jan Klohs Christof Baltes Felicitas Princz-Kranz David Ratering Roger M Nitsch Irene Knuesel Markus Rudin

J Neurosci 2012 Feb;32(5):1705-13

Institute for Biomedical Engineering, Swiss Federal Institute of Technology and University of Zurich, CH-8093 Zurich, Switzerland.

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February 2012

Detection of cerebral microbleeds with quantitative susceptibility mapping in the ArcAbeta mouse model of cerebral amyloidosis.

Authors:

Jan Klohs Andreas Deistung Ferdinand Schweser Joanes Grandjean Marco Dominietto Conny Waschkies Roger M Nitsch Irene Knuesel Jürgen R Reichenbach Markus Rudin

J Cereb Blood Flow Metab 2011 Dec 17;31(12):2282-92. Epub 2011 Aug 17.

Institute for Biomedical Engineering, ETH and University of Zurich, Zurich, Switzerland.

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December 2011

Hippocampal pyramidal cells: the reemergence of cortical lamination.

Authors:

Lutz Slomianka Irmgard Amrein Irene Knuesel Jens Christian Sørensen David P Wolfer

Brain Struct Funct 2011 Nov 20;216(4):301-17. Epub 2011 May 20.

Institute of Anatomy, University of Zürich, 8057 Zürich, Switzerland.

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November 2011

Impaired reelin processing and secretion by Cajal-Retzius cells contributes to granule cell dispersion in a mouse model of temporal lobe epilepsy.

Authors:

Venceslas Duveau Amrita Madhusudan Matteo Caleo Irene Knuesel Jean-Marc Fritschy

Hippocampus 2011 Sep 17;21(9):935-44. Epub 2010 May 17.

Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland.

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September 2011

Reelin-mediated Signaling during Normal and Pathological Forms of Aging.

Authors:

Jana Doehner Irene Knuesel

Aging Dis 2010 Aug 4;1(1):12-29. Epub 2010 Jun 4.

Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland.

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August 2010

Reduced Reelin expression accelerates amyloid-beta plaque formation and tau pathology in transgenic Alzheimer's disease mice.

Authors:

Samira Kocherhans Amrita Madhusudan Jana Doehner Karin S Breu Roger M Nitsch Jean-Marc Fritschy Irene Knuesel

J Neurosci 2010 Jul;30(27):9228-40

Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland.

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July 2010

Reelin-mediated signaling in neuropsychiatric and neurodegenerative diseases.

Authors:

Irene Knuesel

Prog Neurobiol 2010 Aug 22;91(4):257-74. Epub 2010 Apr 22.

Institute of Pharmacology and Toxicology, University of Zurich, Winterthurerstrasse 190, CH-8057 Zurich, Switzerland.

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August 2010

Primate early life stress leads to long-term mild hippocampal decreases in corticosteroid receptor expression.

Authors:

Dimitrula Arabadzisz Rochellys Diaz-Heijtz Irene Knuesel Elisabeth Weber Sonia Pilloud Andrea C Dettling Joram Feldon Amanda J Law Paul J Harrison Christopher R Pryce

Biol Psychiatry 2010 Jun 4;67(11):1106-9. Epub 2010 Feb 4.

Laboratory of Behavioral Neurobiology, Swiss Federal Institute of Technology, Zürich, Switzerland.

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June 2010

Disruption of hippocampus-regulated behavioural and cognitive processes by heterozygous constitutive deletion of SynGAP.

Authors:

Mary Muhia Benjamin K Yee Joram Feldon Foivos Markopoulos Irene Knuesel

Eur J Neurosci 2010 Feb 25;31(3):529-43. Epub 2010 Jan 25.

Laboratory of Behavioural Neurobiology, Swiss Federal Institute of Technology, Schwerzenbach, Switzerland.

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February 2010

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