Dr Iradj Maleki, MD - Mazandaran University of Medical Sciences - Associate Professor of Gasroenterology

Dr Iradj Maleki

MD

Mazandaran University of Medical Sciences

Associate Professor of Gasroenterology

Sari, Mazanadaran | Iran

Main Specialties: Gastroenterology

Additional Specialties: Gastroenterologist

ORCID logohttps://orcid.org/0000-0003-2395-8118

Dr Iradj Maleki, MD - Mazandaran University of Medical Sciences - Associate Professor of Gasroenterology

Dr Iradj Maleki

MD

Introduction

Primary Affiliation: Mazandaran University of Medical Sciences - Sari, Mazanadaran , Iran

Specialties:

Additional Specialties:

Research Interests:

Experience

Sep 1993 - Sep 2001
Mazandaran University of Medical Sciences
Assistant Professor of Internal Medicine
Internal Medicine
Sep 2001
Mazandaran University of Medical Sciences
Associate Professor of Gastroentreology
Internal Medicine

Publications

28Publications

472Reads

2Profile Views

96PubMed Central Citations

Zingiber officinale and oxidative stress in patients with ulcerative colitis: A randomized, placebo-controlled, clinical trial.

Complement Ther Med 2019 Apr 2;43:1-6. Epub 2019 Jan 2.

Department of Clinical Nutrition and Dietetics, Faculty of Nutrition Sciences and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address:

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http://dx.doi.org/10.1016/j.ctim.2018.12.021DOI Listing
April 2019
2 Reads
2.216 Impact Factor

Prevalence of infection in Sari Northern Iran; a population based study.

Gastroenterol Hepatol Bed Bench 2019 ;12(1):31-37

Associate professor, Department of Biostatistics, Faculty of Health, Mazandaran University of Medical Sciences, Sari, Iran.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441486PMC
January 2019
6 Reads

Ginger in gastrointestinal disorders: A systematic review of clinical trials.

Food Sci Nutr 2019 Jan 5;7(1):96-108. Epub 2018 Nov 5.

Department of Clinical Nutrition and Dietetics Faculty of Nutrition Sciences and Food Technology National Nutrition and Food Technology Research Institute Shahid Beheshti University of Medical Sciences Tehran Iran.

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http://dx.doi.org/10.1002/fsn3.807DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341159PMC
January 2019
2 Reads

Evaluation of the Additive Effect of Domperidone on Patients with Refractory Gastroesophageal Reflux Disease Symptoms; A Randomized Double Blind Clinical Trial

Evaluation of the Additive Effect of Domperidone on Patients with Refractory Gastroesophageal Reflux Disease; A Randomized Double Blind Clinical Trial. Middle East J Dig Dis 2019;11:24-31. doi: 10.15171/mejdd.2018.124.

Middle East Journal of Digestive Diseases

BACKGROUND

Gastroesophageal reflux disease (GERD) is a common problem with annoying symptoms. It is associated with negative impact on quality of life. Prokinetic agents may be used in combination with acid suppression agents as an adjunctive in patients with GERD refractory to proton pump inhibitors (PPI) therapy, rather than as sole treatment. This study aimed to evaluate the efficacy of combination of PPI with domperidone (a prokinetic agent) compared with PPI alone in the treatment of patients with refractory GERD.

METHODS

This study was a double blind clinical trial on 29 patients with GERD refractory to PPI during the period of one month. By randomization, the patients were divided into two groups. Group A was treated by pantoprazole 40 mg twice daily and domperidone 10 mg three times a day for a month, while group B was treated by pantoprazole 40 mg twice daily and placebo three times a day. In this study endoscopy was performed to evaluate the prevalence of erosive esophagitis, nonerosive reflux, and hiatal hernia. Manometry was conducted to study the prevalence of dysmotility. GERD symptom questionnaires including the Gastrointestinal Symptom Rating Scale (GSRS), Carlson Dennett, and the Medical Outcomes Study Short Form-36 health survey (SF36) were used before and after treatment for screening GERD and assessing treatment response.

RESULTS

There were 17 (58.62%) women and 12 (41.37%) men. The prevalence of erosive esophagitis and non-erosive reflux, was 10.34% and 89.66%, respectively. There was a significant difference comparing reflux symptoms before and after treatment between the two groups according to reflux and Carlson Dennett questionnaires. At the end of the study, symptoms of reflux significantly improved by treatment. Although, the quality of life questionnaire scores improved by treatment, there was no statistically significant difference in response to treatment between the two groups.

CONCLUSION

In this research, we showed that adding domperidone to PPI could not make any improvement in patients with refractory reflux regarding the quality of life and improving the symptoms.

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January 2019

Prevalence of Helicobacter pylori infection in Sari Northern Iran; a population based study

Prevalence of Helicobacter pylori infection in Sari Northern Iran; a population based study. Gastroenterol Hepatol Bed Bench 2019;12(1):31-37)

Gastroenterology and Hepatology From Bed to Bench

Aim: In this study prevalence rate of Helicobacter pylori and its associated factors have been investigated in urban and rural areas of Sari.

Background: Helicobacter pylori has an important role in gastrointestinal diseases including peptic ulcer and gastric cancer. It is the most common infection in human population worldwide. Hence, the epidemiology of this infection in all parts of the world is of utmost importance.

Methods: We conducted a cross-sectional study on 497 individuals ranging 15-65 years of age in Sari city and its surrounding rural residents. The sampling method was a cluster random sampling multi staged in stratified population by urban and rural areas. Questionnaires for personal and socio-economic data were filled. Blood samples were drawn and kept for analysis (IgG antibody ELISA for Helicobacter pylori). The data was analyzed by SPSS statistical software and Chi-square test and logistic regression were used.

Results: The prevalence of helicobacter infection was 44.5% in the studied population. This prevalence was 41.3% and 47.8% in urban and rural areas, respectively. Just a significant association between the infection and the age of subjects was observed in multiple regression analysis (p=0.001). However, in univariate analysis the level of education was also significantly associated with Helicobacter pylori infection (p=0.015). No other variable was associated with the infection.

Conclusion: The prevalence of helicobacter infection has dropped significantly in the region in comparison with the previous studies during the last 15 years

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December 2018
1 Read

CD4+CD25+CD127low FoxP3+ regulatory T cells in Crohn's disease.

Rom J Intern Med 2018 Sep;56(3):158-166

Department of Immunology, School of Medicine, Babol University of Medical Sciences, Babol, I.R. Iran.

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http://dx.doi.org/10.2478/rjim-2018-0006DOI Listing
September 2018
13 Reads

Concomitant Clozapine and Opium Usage Induced Constipation Leads to Fecal Impaction: A Case Report

Iran J Psychiatry Behav Sci. 2018 September; 12(3):e55054.

Iran J Psychiatry Behav Sci

Abstract

Introduction: Fecal impaction (FI) is a disorder characterized by the inability to evacuate large mass of compacted faces at any level of lower GI tract. The population with highest risk for FI includes elderly patients with neuropsychiatric disorders such as Alzheimer disease, schizophrenia, Parkinson disease, dementia, and severe stroke. Clozapine is an antipsychotic drug that can cause constipation and in some cases, progress to bowel obstruction and finally FI. Opium is a well-known etiology for constipation and its’ concomitant use with clozapine can have an additive effect on this complication.

Case Presentation:We present a 63-year-old man who had been treated for schizophrenia with clozapine (100 mg/TDS for 30 years) and who was using opium for about 20 years. This patient was presented with a history of constipation for 4 weeks, characterized by lack of urge to defecate as well as hard stool. We used a combination of normal saline and glycerin in our patient. In this case, successful therapy was focused on keeping the mechanical balance of colon, to clear out FI.

Conclusions: We concluded that in patients who take opioids or with a history of psychotic disorders who had been treated with antipsychotic drugs, especially low-potency, first generation antipsychotics and clozapine presenting with abdominal pain and constipation should raise immediate concern.

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July 2018
4 Reads

An Ill-Defined Upper Abdominal Mass.

Clin Gastroenterol Hepatol 2018 Mar 13;16(3):e33-e34. Epub 2017 Jul 13.

Department of Internal Medicine, Gut and Liver Research Center, Mazandaran University of Medical Sciences, Sari, Iran.

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http://dx.doi.org/10.1016/j.cgh.2017.07.001DOI Listing
March 2018
10 Reads
7.900 Impact Factor

Decrease of CD4(+) CD25(+) CD127(low) FoxP3(+) regulatory T cells with impaired suppressive function in untreated ulcerative colitis patients.

Autoimmunity 2015 31;48(8):556-61. Epub 2015 Aug 31.

c Gut and Liver Research Center, Mazandaran University of Medical Sciences , Sari , Iran.

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http://dx.doi.org/10.3109/08916934.2015.1070835DOI Listing
September 2016
94 Reads
1 Citation
2.714 Impact Factor

A Comparison between Hybrid and Concomitant Regimens for Eradication: A Randomized Clinical Trial.

Middle East J Dig Dis 2016 Jul;8(3):219-225

Fellow of Gastroenterology, Gut and Liver Research Center, Mazandaran University of Medical Sciences, Sari, Iran.

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http://dx.doi.org/10.15171/mejdd.2016.24DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5045675PMC
July 2016
12 Reads
2 Citations

Parametric Model Evaluation in Examining the Survival of Gastric Cancer Patients Andits Influencing Factors

Global Journal of Health Science. 2017; Vol. 9, No. 3; 260-265

Global Journal of Health Science

Background: Cox proportional hazard model is the most common technique to analysis the variables effect on survival time, but under certain circumstances, parametric models may offer advantages over Cox’s model. In this study we use cox regression and alternative parametric models such as Weibull, exponential, log-normal, logistics and gamma model to evaluate factors affecting survival of patients with gastric cancer. Comparisons were made to find the best model. Method: In this study, data from 643 patients with gastric cancer who were referred to Imam Khomeini hospital with personal details during 2007 to 2013 have been reviewed in order to determine the survival rate of gastric cancer. It was observed that 74 cases were eliminated due to incomplete information and 569 persons were examined. Akaike Information model was used for comparison between models. Result: Of a total of 569 patients, 329 (57.8%) died during the period. The figure of Cox-Snell residuals indicates that only the exponential model does not have better fitness. Weibull, log-normal, log-logistic and gamma models show the better fitness because points are on straight line. At the time of diagnosis, stage with (p<0.0008) and metastasis with (p<0.0219) were subjected to higher risk of death. Conclusion: Based on Akaike's criterion, the Weibull model with Akaike value of 257.165 is the most favorable for survival data.

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July 2016
15 Reads

Translation and validation of the Farsi version of Rome III diagnostic questionnaire for the adult functional gastrointestinal disorders

Toghiani A, Maleki I, Afshar H, Kazemian A. Translation and validation of the Farsi version of Rome

J Res Med Sci

Background: The aim of this study was to validate the Farsi version of Rome III modular questionnaire which contains all functional gastrointestinal disorders (FGIDs). Materials and Methods: We used Rome foundation guidelines for translation of English version into Farsi, and all the steps were performed. In the first step, 2 forward translations into Farsi were completed by two authors separately, and then translators, who participated in Step 1, together with our monitor, compared the two target‑language versions and made some changes. The product of Phase 2 was translated back into English by an American‑Iranian physician. The final step was comparison of the two English versions and validation of the translation. In this step, we compared the final version item by item, and also we used focus groups of patients after pretesting. Results: Our results showed that FGIDs questionnaire diagnosed 153 patients among 169 patients who were diagnosed to have different types of FGIDs. The sensitivity of this questionnaire was 90.5%. It was determined that the odd questions’ values of Cronbach’s alpha was 0.77 (very reliable), and it was 0.71 (very reliable) in other sections. The split‑half test reliability of whole items value was 0.72, which is statistically significant. Conclusion: Our findings showed that the Farsi version of Rome III diagnostic questionnaire for the adult functional gastrointestinal disorders demonstrated good validity and reliability and could be used in clinical studies.

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July 2016
14 Reads

Cancer stem cells CD133 and CD24 in colorectal cancers in Northern Iran.

Gastroenterol Hepatol Bed Bench 2016 ;9(2):132-9

Department of Pathology, Imam Hospital, Mazandaran University of Medical Sciences, Sari, Iran.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4833852PMC
April 2016
10 Reads
2 Citations

Simultaneous Esophageal Squamous Cell Carcinoma and Adenocarcinoma: A Case Report.

Middle East J Dig Dis 2015 Oct;7(4):257-60

Research Assistant, Inflammatory Diseases of Upper Gastrointestinal Tract Research Center, Mazandaran University of Medical Sciences, Sari, Iran.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4655848PMC
October 2015
29 Reads
2 Citations

Comparison Between 10- and 14-Day Hybrid Regimens for Helicobacter pylori Eradication: A Randomized Clinical Trial.

Helicobacter 2015 Aug 4;20(4):299-304. Epub 2015 Mar 4.

Inflammatory Diseases of Upper Gastrointestinal Tract Research Center, Department of Gastroenterology, Mazandaran University of Medical Sciences, Sari, Mazandaran, Iran.

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http://dx.doi.org/10.1111/hel.12202DOI Listing
August 2015
21 Reads
7 Citations
4.110 Impact Factor

Validation of the Persian version of the inflammatory bowel disease questionnaire (IBDQ) in ulcerative colitis patients.

Caspian J Intern Med 2015 ;6(1):20-4

Department of Radiology, Mazandaran University of Medical Sciences, Sari, Iran.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4478114PMC
July 2015
24 Reads
5 Citations

Comparison of quadruple and triple Furazolidone containing regimens on eradication of helicobacter pylori.

Med J Islam Repub Iran 2015 6;29:195. Epub 2015 Apr 6.

Professor PhD, Department of Biostatistics and Community Medicine, Imam Khomeini Hospital, Sari, Iran.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4476222PMC
July 2015
25 Reads
6 Citations

Fecal calprotectin and ulcerative colitis endoscopic activity index as indicators of mucosal healing in ulcerative colitis.

Intern Emerg Med 2015 Apr 4;10(3):321-8. Epub 2014 Nov 4.

Inflammatory Diseases of Upper Gastrointestinal Tract Research Center, Imam Khomeini Hospital, Mazandaran University of Medical Sciences, Amir Mazandarani Street, 48166-33131, Sari, Iran.

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http://dx.doi.org/10.1007/s11739-014-1144-xDOI Listing
April 2015
15 Reads
3 Citations
2.624 Impact Factor

A Comparison between Moderate- and High-dose Furazolidone in Triple Regimens for Helicobacterpylori Eradication in Iran.

Middle East J Dig Dis 2014 Oct;6(4):195-202

Inflammatory Diseases of the Upper Gastrointestinal Tract Research Center, Mazandaran University of Medical Sciences, Sari, Iran.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4208927PMC
October 2014
18 Reads
5 Citations

Serum immunoglobulin A concentration is a reliable biomarker for liver fibrosis in non-alcoholic fatty liver disease.

World J Gastroenterol 2014 Sep;20(35):12566-73

Iradj Maleki, Mahmood Reza Aminafshari, Tarang Taghvaei, Vahid Hosseini, Elahe Orang, Inflammatory Diseases of Upper Gastrointestinal Tract Research Center, Mazandaran University of Medical Sciences, Sari 48166-33131, Iran.

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http://dx.doi.org/10.3748/wjg.v20.i35.12566DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4168092PMC
September 2014
38 Reads
3 Citations
2.370 Impact Factor

Jejunal intussusception caused by a huge Vanek's tumor: a case report.

Gastroenterol Hepatol Bed Bench 2013 ;6(4):210-3

Department of Pathology, Mazandaran University of Medical Sciences, Tehran, Iran.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4017524PMC
May 2014
14 Reads
3 Citations

Quality of life in patients with gastroesophageal reflux disease in an Iranian population.

Gastroenterol Hepatol Bed Bench 2013 ;6(2):96-100

Inflammatory Diseases of Upper Gastrointestinal Tract Research Center, Mazandaran University of Medical Sciences, Sari, Iran.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4017503PMC
May 2014
10 Reads

Comparison of hybrid and sequential therapies for Helicobacter pylori eradication in Iran: a prospective randomized trial.

Helicobacter 2013 Apr 4;18(2):129-34. Epub 2012 Nov 4.

Department of Gastroenterology, Mazandaran University of Medical Sciences, Sari, Mazandaran, Iran.

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http://dx.doi.org/10.1111/hel.12017DOI Listing
April 2013
12 Reads
35 Citations
4.110 Impact Factor

A rare cause of small bowel obstruction in adults: left paraduodenal internal hernia.

Middle East J Dig Dis 2012 Apr;4(2):125-9

Professor,Digestive Disease Research Institute, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4017684PMC
April 2012
12 Reads

Epidemiology of gastroesophageal reflux disease in Tehran, Iran.

J Gastroenterol Hepatol 2007 Sep;22(9):1419-22

Department of Gastroenterology and Hepatology, Taleghani Hospital, Shaheed Beheshti University of Medical Sciences, Tehran, Iran.

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http://dx.doi.org/10.1111/j.1440-1746.2006.04616.xDOI Listing
September 2007
8 Reads
14 Citations
3.504 Impact Factor

Top co-authors

Tarang Taghvaei
Tarang Taghvaei

Tarbiat Modares University

8
Vahid Hosseini
Vahid Hosseini

Digestive Disease Research Center

8
Hafez Fakheri
Hafez Fakheri

Mazandaran University of Medical Sciences

6
Zohreh Bari
Zohreh Bari

Mazandaran University of Medical Sciences

4
Seyed Mohammad Valizadeh
Seyed Mohammad Valizadeh

Mazandaran University of Medical Sciences

4
Maryam Barzin
Maryam Barzin

Shahid Beheshti University of Medical Sciences

3
Alireza Khalilian
Alireza Khalilian

Mazandaran University of Medical Sciences

3
Marjan Mokhtare
Marjan Mokhtare

Mazandaran University of Medical Sciences

3
Hossein Sardarian
Hossein Sardarian

Mazandaran University of Medical Sciences

3
Shahram Agah
Shahram Agah

Colorectal Research Center

2