Publications by authors named "Ira T Lott"

42Publications

Brain amyloid and the transition to dementia in Down syndrome.

Alzheimers Dement (Amst) 2020 11;12(1):e12126. Epub 2020 Nov 11.

Department of Pediatrics Irvine Medical Center University of California Orange California USA.

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November 2020

Distribution of microglial phenotypes as a function of age and Alzheimer's disease neuropathology in the brains of people with Down syndrome.

Alzheimers Dement (Amst) 2020 14;12(1):e12113. Epub 2020 Oct 14.

Department of Pathology and Laboratory Medicine University of California, Irvine Irvine California USA.

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October 2020

Alzheimer-Related Cerebrovascular Disease in Down Syndrome.

Ann Neurol 2020 12 9;88(6):1165-1177. Epub 2020 Oct 9.

Gertrude H. Sergievsky Center and Taub Institute for Research on Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, NY.

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December 2020

Cerebrospinal fluid biomarkers of Alzheimer's disease in a cohort of adults with Down syndrome.

Alzheimers Dement (Amst) 2020 9;12(1):e12057. Epub 2020 Jul 9.

Department of Neurology Washington University in St. Louis School of Medicine St. Louis Missouri USA.

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July 2020

Characterising the brain metalloproteome in Down syndrome patients with concomitant Alzheimer's pathology.

Metallomics 2020 01;12(1):114-132

Florey Institute of Neuroscience and Mental Health, University of Melbourne, and The Melbourne Dementia Research Centre, Parkville, 3010, Victoria, Australia.

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January 2020

Plasma metabolites related to cellular energy metabolism are altered in adults with Down syndrome and Alzheimer's disease.

Dev Neurobiol 2019 07 26;79(7):622-638. Epub 2019 Aug 26.

Department of Neurology, The University of California, Irvine, Irvine, California.

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July 2019

Neuropathological correlates of amyloid PET imaging in Down syndrome.

Dev Neurobiol 2019 07 17;79(7):750-766. Epub 2019 Aug 17.

Geriatric Research Education and Clinical Center, VA Pittsburgh Healthcare System, Pittsburgh, Pennsylvania.

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July 2019

Dementia in Down syndrome: unique insights for Alzheimer disease research.

Nat Rev Neurol 2019 03;15(3):135-147

Sanders Brown Center on Aging, University of Kentucky, Lexington, KY, USA.

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March 2019

Excess Synaptojanin 1 Contributes to Place Cell Dysfunction and Memory Deficits in the Aging Hippocampus in Three Types of Alzheimer's Disease.

Cell Rep 2018 06;23(10):2967-2975

Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Medical Center, New York, NY 10032, USA; Department of Pathology and Cell Biology, Columbia University Medical Center, New York, NY 10032, USA. Electronic address:

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June 2018

Cerebrovascular pathology in Down syndrome and Alzheimer disease.

Acta Neuropathol Commun 2017 Dec 1;5(1):93. Epub 2017 Dec 1.

Department of Pediatrics, University of California, Irvine, Irvine, CA, USA.

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December 2017

Down syndrome: age-dependence of PiB binding in postmortem frontal cortex across the lifespan.

Neurobiol Aging 2017 06 14;54:163-169. Epub 2017 Mar 14.

Sanders-Brown Center on Aging, University of Kentucky, Lexington, KY, USA; Department of Pharmacology & Nutritional Sciences, University of Kentucky, Lexington, KY, USA. Electronic address:

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June 2017

Metabolic and Growth Rate Alterations in Lymphoblastic Cell Lines Discriminate Between Down Syndrome and Alzheimer's Disease.

J Alzheimers Dis 2017 ;55(2):737-748

Department of Neurobiology and Behavior, Institute for Memory Impairments and Neurological Disorders (iMIND), and Center for the Neurobiology of Learning and Memory (CNLM), University of California, Irvine, CA, USA.

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February 2018

Neuronal exosomes reveal Alzheimer's disease biomarkers in Down syndrome.

Alzheimers Dement 2017 May 15;13(5):541-549. Epub 2016 Oct 15.

Department of Neuroscience, Medical University of South Carolina, Charleston, SC, USA; The Knoebel Institute for Healthy Aging, University of Denver, Denver, CO, USA; The Center on Aging, Department of Neuroscience, Medical University of South Carolina, Charleston, SC, USA; Center for Alzheimer Research, Karolinska Institutet, Huddinge, Sweden. Electronic address:

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May 2017

Gait dyspraxia as a clinical marker of cognitive decline in Down syndrome: A review of theory and proposed mechanisms.

Brain Cogn 2016 Apr 27;104:48-57. Epub 2016 Feb 27.

University of Florida College of Medicine, Department of Neurology, Room L3-100, McKnight Brain Institute, 1149 Newell Drive, Gainesville, FL 32611, United States. Electronic address:

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April 2016