Ira Shoulson

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Ira Shoulson

Publications by authors named "Ira Shoulson"

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77Publications

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Selected health and lifestyle factors, cytosine-adenine-guanine status, and phenoconversion in Huntington's disease.

Mov Disord 2018 Mar 3;33(3):472-478. Epub 2018 Jan 3.

Department of Neurology, Georgetown University, Washington, D.C., USA.

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March 2018

A comprehensive review of the FDA-approved labels of diabetes drugs: Indications, safety, and emerging cardiovascular safety data.

J Diabetes Complications 2017 Dec 12;31(12):1719-1727. Epub 2017 Aug 12.

Program for Regulatory Science & Medicine, Georgetown University, Washington, DC, United States.

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December 2017

I-SPY 2 Breast Cancer Trial as a Model for Innovation in Alzheimer Disease Therapies.

JAMA Neurol 2017 Sep;74(9):1027-1028

Program for Regulatory Science & Medicine, Georgetown University, Washington, DC.

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September 2017

Prediction of cognition in Parkinson's disease with a clinical-genetic score: a longitudinal analysis of nine cohorts.

Lancet Neurol 2017 08 16;16(8):620-629. Epub 2017 Jun 16.

Neurogenomics Laboratory and Parkinson Personalized Medicine Program of Harvard Medical School and Brigham and Women's Hospital, Boston, MA, USA; Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Boston, MA, USA; Department of Neurology, Brigham and Women's Hospital, Boston, MA, USA; Department of Neurology, Massachusetts General Hospital, Boston, MA, USA; Biomarkers Program, Harvard NeuroDiscovery Center, Boston, MA, USA. Electronic address:

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August 2017

A randomized, double-blind, placebo-controlled trial of coenzyme Q10 in Huntington disease.

Neurology 2017 Jan 2;88(2):152-159. Epub 2016 Dec 2.

From Cooper University Healthcare at Rowan University (A.M.), Camden, NJ; University of Rochester (M.M., K.K., E.A.d.B., K.B., P.C.); Weill Cornell Medical Center (F.B.); Columbia Presbyterian Medical Center (K.M.), New York, NY; Johns Hopkins Medical Center (C.R.), Baltimore, MD; Georgetown University (I.S.), Washington, DC; NINDS (P.G.), Bethesda, MD; Hereditary Neurological Disease Center (W.M.M.), Wichita, KS; The Centre for Movement Disorders (M.G.), Toronto, Canada; Indiana University School of Medicine (J.W.), Indianapolis; Colorado Neurological Institute (R.K.), Englewood; University of Tennessee Health Science Center (M.S.L.), Memphis; London Health Sciences Centre (M.J.), Canada; Massachusetts General Hospital (H.D.R.), Boston; Struthers Parkinson's Center (M.N.), Minneapolis, MN; University of Kansas Medical Center (R.M.D.), Kansas City; Rush University Medical Center (K.M.S.), Chicago, IL; University of Texas Southwestern Medical Center (P.O.), Dallas; University of Michigan (K.C.), Ann Arbor; Wake Forest University (F.W.), Winston-Salem, NC; University of Alberta (W.M.), Edmonton, Canada; University of California Davis (V.L.W.), Sacramento; Westmead Hospital (E. McCusker), Westmead, Australia; Baylor College of Medicine (J.J.), Houston, TX; University of Miami Miller School of Medicine (C.S.), FL; University of South Florida (J.S.-R.), Tampa; Duke University (B.S.), Durham, NC; University of Calgary (O.S.), Canada; Emory University School of Medicine (S.A.F.), Atlanta, GA; Albany Medical College (D.S.H., Eric Molho), NY; University of Cincinnati (F.R.), OH; Mayo Clinic Arizona (J.N.C.), Scottsdale; Butler Hospital (J.H.F.), Providence, RI; Washington University (J.S.P.), St. Louis, MO; Feinstein Institute for Medical Research (A.F.), Manhasset, NY; Georgetown University (K.A.), Washington, DC; University of Florida (R.R., N.R.M.), Gainesville; Johns Hopkins University (R.L.M.), Baltimore, MD; University of Nevada School of Medicine (E.S.F.), Reno; University of British Columbia (L.A.R.), Vancouver, Canada; University of Pittsburgh (V.S.), PA; Ohio State University (S.K.), Columbus; The Cooper University Health System (A.C.), Camden, NJ; Idaho Elks Rehabilitation Hospital (L.S.), Boise, ID; University of Iowa (E.E.), Iowa City; North York General Hospital 1 (S.E.), Toronto, Canada; St. Luke's Hospital (N.D.), Allentown, PA; North York General Hospital 2 (W.L.A.F.), University of Toronto, Canada; Washington Regional Medical Center (A.D.), Fayetteville, AR; Beth-Israel Deaconess Medical Center (S.F.), Boston, MA; NJ Neuroscience Institute (P.H.), Edison; University of California Irvine (N.H.); The University of Alabama at Birmingham (L.S.D.); and Massachusetts General Hospital (M.C.), Harvard Medical School, Boston.

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January 2017

Informativeness of Early Huntington Disease Signs about Gene Status.

J Huntingtons Dis 2015 ;4(3):271-7

Department of Neurology, Georgetown University, Washington, DC, USA.

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July 2016

Optimal Expectations and Limited Medical Testing: Evidence from Huntington Disease: Corrigendum.

Am Econ Rev 2016 Jun;106(6):1562-5

Department of Neurology, University of Rochester Medical Center, Rochester, NY.

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June 2016

Clinical-Genetic Associations in the Prospective Huntington at Risk Observational Study (PHAROS): Implications for Clinical Trials.

Authors:
Kevin Michael Biglan Ira Shoulson Karl Kieburtz David Oakes Elise Kayson M Aileen Shinaman Hongwei Zhao Megan Romer Anne Young Steven Hersch Jack Penney Karen Marder Jane Paulsen Kimberly Quaid Eric Siemers Caroline Tanner William Mallonee Greg Suter Richard Dubinsky Carolyn Gray Martha Nance Scott Bundlie Dawn Radtke Sandra Kostyk Corrine Baic James Caress Francis Walker Victoria Hunt Christine O'Neill Sylvain Chouinard Stewart Factor Timothy Greenamyre Cathy Wood-Siverio Jody Corey-Bloom David Song Guerry Peavy Carol Moskowitz Melissa Wesson Ali Samii Thomas Bird Hillary Lipe Karen Blindauer Frederick Marshall Carol Zimmerman Jody Goldstein Diana Rosas Peter Novak John Caviness Charles Adler Amy Duffy Vicki Wheelock Teresa Tempkin David Richman Lauren Seeberger Roger Albin Kelvin L Chou Brad Racette Joel S Perlmutter Susan Perlman Yvette Bordelon Wayne Martin Marguerite Wieler Blair Leavitt Lynn Raymond Joji Decolongon Lorne Clarke Joseph Jankovic Christine Hunter Robert A Hauser Juan Sanchez-Ramos Sarah Furtado Oksana Suchowersky Mary Lou Klimek Mark Guttman Rustom Sethna Andrew Feigin Marie Cox Barbara Shannon Alan Percy Leon Dure Madaline Harrison William Johnson Donald Higgins Eric Molho Constance Nickerson Sharon Evans Douglas Hobson Carlos Singer Nestor Galvez-Jimenez Kathleen Shannon Cynthia Comella Christopher Ross Marie H Saint-Hilaire Claudia Testa Adam Rosenblatt Penelope Hogarth William Weiner Peter Como Rajeev Kumar Candace Cotto Julie Stout Alicia Brocht Arthur Watts Shirley Eberly Christine Weaver Tatiana Foroud James Gusella Marcy MacDonald Richard Myers Stanley Fahn Clifford Shults

JAMA Neurol 2016 Jan;73(1):102-10

Department of Neuroscience, University of California, San Diego, La Jolla.

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January 2016

Association between α-synuclein blood transcripts and early, neuroimaging-supported Parkinson's disease.

Brain 2015 Sep 28;138(Pt 9):2659-71. Epub 2015 Jul 28.

1 Neurogenomics Lab and Parkinson Personalized Medicine Program, Harvard Medical School and Brigham and Women's Hospital, Cambridge, MA 02139, USA 2 Department of Neurology, Massachusetts General Hospital, Boston, MA 02114, USA 4 Ann Romney Centre for Neurologic Diseases, Brigham and Women's Hospital, Boston, MA 02115, USA 5 Biomarkers Program, Harvard NeuroDiscovery Center, Boston, MA 02115, USA 7 Department of Neurology, Brigham and Women's Hospital, Boston, MA 02115, USA

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September 2015

Impact of disclosure of individual imaging results in a multi-center Parkinson clinical trial.

J Parkinsons Dis 2014 ;4(4):629-38

Program for Regulatory Science & Medicine (PRSM), Georgetown University, Washington, D.C., USA.

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August 2015

Mendelian randomization of serum urate and parkinson disease progression.

Ann Neurol 2014 Dec 3;76(6):862-8. Epub 2014 Oct 3.

Department of Nutrition, Harvard School of Public Health, Boston, MA; Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.

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December 2014

Reply: Unusual DAT scan results.

Mov Disord 2013 Jun 4;28(6):847. Epub 2013 Apr 4.

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June 2013

A practical approach to remote longitudinal follow-up of Parkinson's disease: the FOUND study.

Mov Disord 2014 May 11;29(6):743-9. Epub 2014 Feb 11.

Clinical Research, The Parkinson's Institute, Sunnyvale, California, USA; Department of Health Research and Policy, Stanford University, Palo Alto, California, USA.

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May 2014

A randomized clinical trial of high-dosage coenzyme Q10 in early Parkinson disease: no evidence of benefit.

Authors:
M Flint Beal David Oakes Ira Shoulson Claire Henchcliffe Wendy R Galpern Richard Haas Jorge L Juncos John G Nutt Tiffini Smith Voss Bernard Ravina Clifford M Shults Karen Helles Victoria Snively Mark F Lew Brian Griebner Arthur Watts Shan Gao Emmanuelle Pourcher Louisette Bond Katie Kompoliti Pinky Agarwal Cherissa Sia Mandar Jog Linda Cole Munira Sultana Roger Kurlan Irene Richard Cheryl Deeley Cheryl H Waters Angel Figueroa Ani Arkun Matthew Brodsky William G Ondo Christine B Hunter Joohi Jimenez-Shahed Alicia Palao Janis M Miyasaki Julie So James Tetrud Liza Reys Katharine Smith Carlos Singer Anita Blenke David S Russell Candace Cotto Joseph H Friedman Margaret Lannon Lin Zhang Edward Drasby Rajeev Kumar Thyagarajan Subramanian Donna Stuppy Ford David A Grimes Diane Cote Jennifer Conway Andrew D Siderowf Marian Leslie Evatt Barbara Sommerfeld Abraham N Lieberman Michael S Okun Ramon L Rodriguez Stacy Merritt Camille Louise Swartz W R Wayne Martin Pamela King Natividad Stover Stephanie Guthrie Ray L Watts Anwar Ahmed Hubert H Fernandez Adrienna Winters Zoltan Mari Ted M Dawson Becky Dunlop Andrew S Feigin Barbara Shannon Melissa Jill Nirenberg Mattson Ogg Samuel A Ellias Cathi-Ann Thomas Karen Frei Ivan Bodis-Wollner Sofya Glazman Thomas Mayer Robert A Hauser Rajesh Pahwa April Langhammer Ranjit Ranawaya Lorelei Derwent Kapil D Sethi Buff Farrow Rajan Prakash Irene Litvan Annette Robinson Alok Sahay Maureen Gartner Vanessa K Hinson Samuel Markind Melisa Pelikan Joel S Perlmutter Johanna Hartlein Eric Molho Sharon Evans Charles H Adler Amy Duffy Marlene Lind Lawrence Elmer Kathy Davis Julia Spears Stephanie Wilson Maureen A Leehey Neal Hermanowicz Shari Niswonger Holly A Shill Sanja Obradov Alex Rajput Marilyn Cowper Stephanie Lessig David Song Deborah Fontaine Cindy Zadikoff Karen Williams Karen A Blindauer Jo Bergholte Clara Schindler Propsom Mark A Stacy Joanne Field Dragos Mihaila Mark Chilton Ergun Y Uc Jeri Sieren David K Simon Lauren Kraics Althea Silver James T Boyd Robert W Hamill Christopher Ingvoldstad Jennifer Young Karen Thomas Sandra K Kostyk Joanne Wojcieszek Ronald F Pfeiffer Michel Panisset Monica Beland Stephen G Reich Michelle Cines Nancy Zappala Jean Rivest Richard Zweig L Pepper Lumina Colette Lynn Hilliard Stephen Grill Marye Kellermann Paul Tuite Susan Rolandelli Un Jung Kang Joan Young Jayaraman Rao Maureen M Cook Lawrence Severt Karyn Boyar

JAMA Neurol 2014 May;71(5):543-52

Department of Neurology, Beth Israel Medical Center, New York, New York.

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May 2014

Longitudinal follow-up of SWEDD subjects in the PRECEPT Study.

Neurology 2014 May 23;82(20):1791-7. Epub 2014 Apr 23.

From the Institute for Neurodegenerative Disorders (K.M., J.S., D.J.), University of Rochester (S.E., D.O.), Rochester, NY; Georgetown University (I.S.), Washington, DC; University of Toronto (A.E.L.); and Western University (C.H.), London, Ontario, Canada.

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May 2014

Approaches and costs for sharing clinical research data.

JAMA 2014 Mar;311(12):1201-2

Departments of Neurology, Pharmacology, and Human Science, Program for Regulatory Science and Medicine, Georgetown University.

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March 2014

Pharmacogenomic characterization of gemcitabine response--a framework for data integration to enable personalized medicine.

Pharmacogenet Genomics 2014 Feb;24(2):81-93

aInnovation Center for Biomedical Informatics bLombardi Comprehensive Cancer Center, Developmental Therapeutics Program cDepartment of Neurology, Georgetown University Medical Center dDepartment of Mathematics and Statistics, Georgetown University, Washington, District of Columbia eESAC Inc., Rockville fUS Food and Drug Administration, Silver Spring, Maryland, USA.

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February 2014

Movement disorder society unified Parkinson disease rating scale experiences in daily living: longitudinal changes and correlation with other assessments.

Mov Disord 2013 Dec 9;28(14):1980-6. Epub 2013 Oct 9.

Morton and Gloria Shulman Movement Disorders Clinic and the Edmond J. Safra Program in Parkinson's Disease, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada.

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December 2013

Natural history of Huntington disease.

JAMA Neurol 2013 Dec;70(12):1520-30

Department of Neurology, Georgetown University Medical Center, Washington, DC.

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December 2013

Relationship of Mediterranean diet and caloric intake to phenoconversion in Huntington disease.

JAMA Neurol 2013 Nov;70(11):1382-8

Departments of Neurology and Psychiatry, Columbia University College of Physicians and Surgeons, New York, New York3Gertrude H. Sergievsky Center, Columbia University Medical Center, New York, New York.

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November 2013

HTRF analysis of soluble huntingtin in PHAROS PBMCs.

Neurology 2013 Sep 21;81(13):1134-40. Epub 2013 Aug 21.

From the Massachusetts General Hospital (M.M.-L., R.E.G., J.J.R., H.D.R., S.M., A.B.Y., S.M.H.), MassGeneral Institute for Neurodegenerative Disease, Department of Neurology, Charlestown, MA; University of Rochester Medical Center (S.E., D.O.), Department of Biostatistics and Computational Biology, Rochester, NY; Veterans Administration Hospital (W.M.), Bedford, MA; and Program for Regulatory Science & Medicine (I.S.), Georgetown University, Washington, DC.

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September 2013

Limited Life Expectancy, Human Capital and Health Investments.

Am Econ Rev 2013 Aug;103(5):1977-2002

Department of Neurology, Johns Hopkins University, Baltimore, MD.

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August 2013

Reply: Unusual DAT scan results.

Mov Disord 2013 Jun 4;28(6):847. Epub 2013 Apr 4.

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June 2013

In Memoriam: Robert J. Joynt, MD, PhD (1925-2012).

Authors:
Ira Shoulson

Arch Neurol 2012 Nov;69(11):1518-9

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November 2012

Use of Tetrabenazine in Huntington Disease Patients on Antidepressants or with Advanced Disease: Results from the TETRA-HD Study.

PLoS Curr 2011 Nov 13;3:RRN1283. Epub 2011 Nov 13.

Neurologist, Johns Hopkins University; Department of Neurology, University of Rochester, Rochester, NY, USA; University of Rochester Medical Center, Rochester NY; Movement Disorders Fellow, Johns Hopkins University; Partner, KM Pharmaceutical Consulting; Associate Professor of Neurology, University of Rochester School of Medicine and Dentistry; Professor of Neurology, Pharmacology & Human Science. Director, Program for Regulatory Science & Medicine (PRSM) and Doctor.

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November 2011

Serum urate and probability of dopaminergic deficit in early "Parkinson's disease".

Mov Disord 2011 Aug 29;26(10):1864-8. Epub 2011 Apr 29.

Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts, USA.

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August 2011

Altered cholesterol and fatty acid metabolism in Huntington disease.

J Clin Lipidol 2010 Jan-Feb;4(1):17-23

Division of Epidemiology, Department of Community and Preventive Medicine and Preventive Cardiology Unit, Box 644, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Rochester, NY 14620, USA.

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May 2011

Milestones in huntington disease.

Mov Disord 2011 May;26(6):1127-33

Program for Regulatory Science and Medicine, Georgetown University, Washington, District of Columbia, USA.

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May 2011

Predictors of time to requiring dopaminergic treatment in 2 Parkinson's disease cohorts.

Mov Disord 2011 Mar 1;26(4):608-13. Epub 2011 Feb 1.

Morton and Gloria Shulman Movement Disorders Centre, Toronto Western Hospital, Toronto, Ontario, Canada.

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March 2011

Perception, experience, and response to genetic discrimination in Huntington disease: the international RESPOND-HD study.

Am J Med Genet B Neuropsychiatr Genet 2010 Jul;153B(5):1081-93

Department of Family Medicine, John P. McGovern Center for Health, Humanities and the Human Spirit, University of Texas Medical School at Houston, Houston, Texas, USA.

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July 2010

Therapeutic directions for Parkinson's disease.

Authors:
Ira Shoulson

Mov Disord 2010 ;25 Suppl 1:S152-4

Department of Neurology, University of Rochester, Rochester, New York 14620, USA.

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June 2010

A comparison of treatment thresholds in two large Parkinson's disease clinical trial cohorts.

Mov Disord 2009 Dec;24(16):2370-8

Morton and Gloria Shulman Movement Disorders Centre, Toronto Western Hospital, Toronto, Ontario, Canada.

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December 2009

Huntington disease: pathogenesis, biomarkers, and approaches to experimental therapeutics.

Parkinsonism Relat Disord 2009 Dec;15 Suppl 3:S135-8

Professor of Psychiatry, Neurology, Pharmacology and Neuroscience, Johns Hopkins University School of Medicine, CMSC 8-121, 600 North Wolfe Street, Baltimore, MD 21287, USA.

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December 2009

Communicating clinical trial results to research participants.

Arch Neurol 2008 Dec;65(12):1590-5

Department of Neurology, University of Rochester Medical Center, 1351 Mt Hope Ave, Ste 223, Rochester, NY 14620, USA.

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December 2008

Fear of health insurance loss among individuals at risk for Huntington disease.

Am J Med Genet A 2008 Aug;146A(16):2070-7

Department of Economics, The University of Chicago, Chicago, Illinois, USA.

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August 2008

The relationship between CAG repeat length and clinical progression in Huntington's disease.

Mov Disord 2008 Jul;23(9):1223-7

Department of Neurology, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA.

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July 2008

Disease progression and pharmacodynamics in Parkinson disease - evidence for functional protection with levodopa and other treatments.

J Pharmacokinet Pharmacodyn 2006 Jun 20;33(3):281-311. Epub 2006 Apr 20.

Department of Pharmacology & Clinical Pharmacology, University of Auckland, Auckland, New Zealand.

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June 2006

Sociology of collaborative research groups.

Authors:
Ira Shoulson

Amyotroph Lateral Scler Other Motor Neuron Disord 2004 Sep;5 Suppl 1:118-20

University of Rochester School of Medicine and Dentistry, NY 14620, USA.

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September 2004

Preempting genetic discrimination and assaults on privacy: report of a symposium.

Am J Med Genet A 2003 Aug;120A(4):589-93

University of Rochester Medical Center, Rochester, New York 14620, USA.

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August 2003

Experimental neurotherapeutics: leaps and bounds.

Authors:
Ira Shoulson

Arch Neurol 2002 May;59(5):689-91

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May 2002