Publications by authors named "Ioannis Dragatsis"

39Publications

Injured adult neurons regress to an embryonic transcriptional growth state.

Nature 2020 05 15;581(7806):77-82. Epub 2020 Apr 15.

Department of Neurosciences, University of California San Diego, La Jolla, CA, USA.

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http://dx.doi.org/10.1038/s41586-020-2200-5DOI Listing
May 2020

Striatal Projection Neurons Require Huntingtin for Synaptic Connectivity and Survival.

Cell Rep 2020 01;30(3):642-657.e6

Department of Neurobiology, Duke University Medical Center, Durham, NC 27710, USA; Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA; Duke Institute for Brain Sciences, Durham, NC 27710, USA; Regeneration Next Initiative, Duke University, Durham, NC 27710, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2019.12.069DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7025500PMC
January 2020

Huntington's Disease Pathogenesis Is Modified In Vivo by Alfy/Wdfy3 and Selective Macroautophagy.

Neuron 2020 03 30;105(5):813-821.e6. Epub 2019 Dec 30.

Doctoral Program in Neurobiology and Behavior, Department of Neuroscience, Columbia University, New York, NY, USA; Department of Neurology, Columbia University, New York, NY, USA; Department of Pathology and Cell Biology, Columbia University, New York, NY, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neuron.2019.12.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7060123PMC
March 2020

ELP1 Splicing Correction Reverses Proprioceptive Sensory Loss in Familial Dysautonomia.

Am J Hum Genet 2019 04 21;104(4):638-650. Epub 2019 Mar 21.

Center for Genomic Medicine, Massachusetts General Hospital Research Institute and Harvard Medical School, Boston, MA 02114, USA; Department of Neurology, Massachusetts General Hospital Research Institute and Harvard Medical School, Boston, MA 02114, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ajhg.2019.02.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451698PMC
April 2019

Elimination of huntingtin in the adult mouse leads to progressive behavioral deficits, bilateral thalamic calcification, and altered brain iron homeostasis.

PLoS Genet 2017 Jul 17;13(7):e1006846. Epub 2017 Jul 17.

Department of Physiology, The University of Tennessee, Health Science Center, Memphis, Tennessee, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1006846DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5536499PMC
July 2017

Role of major and brain-specific Sgce isoforms in the pathogenesis of myoclonus-dystonia syndrome.

Neurobiol Dis 2017 Feb 24;98:52-65. Epub 2016 Nov 24.

Department of Neurology, University of Tennessee Health Science Center, Memphis, TN 38163, USA; Department of Anatomy and Neurobiology, University of Tennessee Health Science Center, Memphis, TN 38163, USA. Electronic address:

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http://dx.doi.org/10.1016/j.nbd.2016.11.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5283163PMC
February 2017

Familial Dysautonomia: Mechanisms and Models.

Genet Mol Biol 2016 Oct-Dec;39(4):497-514. Epub 2016 Aug 4.

Department of Physiology, The University of Tennessee, Memphis, TN, USA.

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http://dx.doi.org/10.1590/1678-4685-GMB-2015-0335DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5127153PMC
August 2016

Huntingtin is required for normal excitatory synapse development in cortical and striatal circuits.

J Neurosci 2014 Jul;34(28):9455-72

Department of Cell Biology, Duke University Medical Center, Durham, North Carolina 27710, Department of Neurobiology, Duke University Medical Center, Durham, North Carolina 27710, Duke Institute for Brain Sciences, Durham, North Carolina 27710

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http://dx.doi.org/10.1523/JNEUROSCI.4699-13.2014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4087216PMC
July 2014

IKAP deficiency in an FD mouse model and in oligodendrocyte precursor cells results in downregulation of genes involved in oligodendrocyte differentiation and myelin formation.

PLoS One 2014 23;9(4):e94612. Epub 2014 Apr 23.

Department of Developmental Biology and Cancer Research, Institute of Medical Research Israel-Canada, The Hebrew University Hadassah Medical School, Jerusalem, Israel.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0094612PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3997429PMC
January 2015

IKAP expression levels modulate disease severity in a mouse model of familial dysautonomia.

Hum Mol Genet 2012 Dec 24;21(23):5078-90. Epub 2012 Aug 24.

Department of Physiology, The University of Tennessee, Health Science Center, Memphis, TN 38163, USA.

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http://dx.doi.org/10.1093/hmg/dds354DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3490515PMC
December 2012

Deletion of exon 20 of the Familial Dysautonomia gene Ikbkap in mice causes developmental delay, cardiovascular defects, and early embryonic lethality.

PLoS One 2011 28;6(10):e27015. Epub 2011 Oct 28.

Department of Physiology, College of Medicine, The University of Tennessee, Health Science Center, Memphis, Tennessee, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0027015PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3203942PMC
March 2012

Genetics and neuropathology of Huntington's disease.

Int Rev Neurobiol 2011 ;98:325-72

Department of Anatomy & Neurobiology, The University of Tennessee Health Science Center, 855 Monroe Ave. Memphis, TN 38163, USA.

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http://dx.doi.org/10.1016/B978-0-12-381328-2.00014-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4458347PMC
January 2012

Presenilins are essential for regulating neurotransmitter release.

Nature 2009 Jul;460(7255):632-6

Center for Neurologic Diseases, Brigham & Women's Hospital, Program in Neuroscience, Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1038/nature08177DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2744588PMC
July 2009

The hormonal action of IGF1 in postnatal mouse growth.

Proc Natl Acad Sci U S A 2008 Dec 25;105(49):19378-83. Epub 2008 Nov 25.

Department of Genetics and Development, Columbia University, 1150 St. Nicholas Avenue, New York, NY 10032, USA.

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http://dx.doi.org/10.1073/pnas.0809223105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2614769PMC
December 2008

Congenital hydrocephalus associated with abnormal subcommissural organ in mice lacking huntingtin in Wnt1 cell lineages.

Hum Mol Genet 2009 Jan 6;18(1):142-50. Epub 2008 Oct 6.

Department of Physiology, The University of Tennessee, Health Science Center, Memphis, TN 38163, USA.

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https://academic.oup.com/hmg/article-lookup/doi/10.1093/hmg/
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http://dx.doi.org/10.1093/hmg/ddn324DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3298867PMC
January 2009

A transgenic mouse class-III beta tubulin reporter using yellow fluorescent protein.

Genesis 2007 Sep;45(9):560-9

Department of Anatomy and Neurobiology, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA.

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http://dx.doi.org/10.1002/dvg.20325DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2814058PMC
September 2007

Huntingtin inhibits caspase-3 activation.

EMBO J 2006 Dec 23;25(24):5896-906. Epub 2006 Nov 23.

Neuroapoptosis Laboratory, Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA.

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http://dx.doi.org/10.1038/sj.emboj.7601445DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1698892PMC
December 2006

Neuronal deletion of Lepr elicits diabesity in mice without affecting cold tolerance or fertility.

Am J Physiol Endocrinol Metab 2005 Sep 3;289(3):E403-11. Epub 2005 May 3.

Department of Pediatrics, Division of Molecular Genetics, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA.

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http://dx.doi.org/10.1152/ajpendo.00535.2004DOI Listing
September 2005

Huntingtin-associated protein 1 (Hap1) mutant mice bypassing the early postnatal lethality are neuroanatomically normal and fertile but display growth retardation.

Hum Mol Genet 2004 Dec 20;13(24):3115-25. Epub 2004 Oct 20.

Department of Physiology, College of Medicine, The University of Tennessee, Health Science Center, Memphis, TN 38163, USA.

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http://dx.doi.org/10.1093/hmg/ddh328DOI Listing
December 2004

An allelic series for the leptin receptor gene generated by CRE and FLP recombinase.

Mamm Genome 2004 Sep;15(9):677-85

Department of Pediatrics, Division of Molecular Genetics, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA.

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http://dx.doi.org/10.1007/s00335-004-2340-1DOI Listing
September 2004

Transgenic rescue of insulin receptor-deficient mice.

J Clin Invest 2004 Jul;114(2):214-23

Department of Medicine, Institute of Human Nutrition, College of Physicians and Surgeons, Columbia University, New York, New York, USA.

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http://dx.doi.org/10.1172/JCI21645DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC449751PMC
July 2004

Wild-type huntingtin plays a role in brain development and neuronal survival.

Mol Neurobiol 2003 Dec;28(3):259-76

Department of Anatomy and Neurobiology, College of Medicine, The University of Tennessee, The Health Science Center, Memphis, TN 38163.

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http://dx.doi.org/10.1385/MN:28:3:259DOI Listing
December 2003

Presynaptic BDNF required for a presynaptic but not postsynaptic component of LTP at hippocampal CA1-CA3 synapses.

Neuron 2003 Sep;39(6):975-90

Center for Neurobiology and Behavior, Columbia University, 722 West 168th Street, New York, NY 10032, USA.

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http://dx.doi.org/10.1016/s0896-6273(03)00543-9DOI Listing
September 2003

Insulin-like growth factor (IGF) signaling through type 1 IGF receptor plays an important role in remyelination.

J Neurosci 2003 Aug;23(20):7710-8

Department of Pathology and The Center for Neurobiology and Behavior, Columbia University, New York, New York 10032, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6740767PMC
August 2003

Time course of early motor and neuropathological anomalies in a knock-in mouse model of Huntington's disease with 140 CAG repeats.

J Comp Neurol 2003 Oct;465(1):11-26

Department of Neurology, University of California at Los Angeles, Los Angeles, California 90095, USA.

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http://dx.doi.org/10.1002/cne.10776DOI Listing
October 2003

Overgrowth of a mouse model of the Simpson-Golabi-Behmel syndrome is independent of IGF signaling.

Dev Biol 2002 Mar;243(1):185-206

Department of Genetics and Development, Columbia University, New York, New York 10032, USA.

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http://dx.doi.org/10.1006/dbio.2001.0554DOI Listing
March 2002