Publications by authors named "Inwoo Seo"

2 Publications

  • Page 1 of 1

Root Extract Induces the Anagen Phase in the Human Hair Follicle Dermal Papilla Cells.

Pharmaceutics 2021 Jul 27;13(8). Epub 2021 Jul 27.

School of Chemical Engineering, Sungkyunkwan University, Suwon 16419, Korea.

Restoring hair follicles by inducing the anagen phase is a promising approach to prevent hair loss. Hair follicle dermal papilla cells (HFDPCs) play a major role in hair growth via the telogen-to-anagen transition. The therapeutic effect of activates β-catenin in HFDPCs, thereby inducing the anagen phase. The HFDPCs were treated with root extract (MARE) to promote hair growth. It contains chlorogenic acid and umbelliferone and is not cytotoxic to HFDPCs at a concentration of 20%. It was demonstrated that a small amount of MARE enhances growth factor secretion (related to the telogen-to-anagen transition). Activation of β-catenin was observed in MARE-treated HFDPCs, which is crucial for inducing the anagen phase. The effect of conditioned medium derived from MARE-treated HFDPCs on keratinocytes and endothelial cells was also investigated. The findings of this study demonstrate the potency of MARE in eliciting the telogen-to-anagen transition.
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http://dx.doi.org/10.3390/pharmaceutics13081155DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8399394PMC
July 2021

Poly(amino ester)-Based Polymers for Gene and Drug Delivery Systems and Further Application toward Cell Culture System.

Macromol Biosci 2021 Aug 12;21(8):e2100106. Epub 2021 Jun 12.

School of Chemical Engineering, Sungkyunkwan University, Suwon, 16419, Republic of Korea.

Various synthetic polymers based on poly(amino ester) (PAE) are suggested as candidates for gene and drug delivery owing to their pH-responsiveness, which contributes to efficient delivery performance. PAE-based pH-responsive polymers are more biodegradable and hydrophilic than other types of pH-responsive polymers. The functionality of PAE-based polymers can be reinforced by using different chemical modifications to improve the efficiency of gene and drug delivery. Additionally, PAE-based polymers are used in many ways in the biomedical field, such as in transdermal delivery and stem cell culture systems. Here, the recent novel PAE-based polymers designed for gene and drug delivery systems along with their further applications toward adult stem cell culture systems are reviewed. The synthetic tactics are contemplated and pros and cons of each type of polymer are analyzed, and detailed examples of the different types are analyzed.
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http://dx.doi.org/10.1002/mabi.202100106DOI Listing
August 2021
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