Publications by authors named "Ingrid Kockum"

100Publications

Pregnancy does not modify the risk of MS in genetically susceptible women.

Neurol Neuroimmunol Neuroinflamm 2020 Nov 9;7(6). Epub 2020 Oct 9.

From the Divisions of Epidemiology and Biostatistics (C.J.A., S.L.W.), School of Public Health, University of California, Berkeley, Berkeley, CA; Genetic Epidemiology and Genomics Laboratory (X.S., L.F.B.), University of California, Berkeley, Berkeley, CA; School of Public Health (P.T.B.), University of California, Berkeley, Berkeley, CA, USA; Department of Research & Evaluation (E.G., J.B.S., A.H.X.), Kaiser Permanente Southern California, Los Angeles, CA; Kaiser Permanente Division of Research (K.H.B., T.C., C.S.), Kaiser Permanente Northern California, Oakland, CA; University of Oslo (S.D.B.), Institute of Clinical Medicine & Oslo University Hospital, Department of Neurology, Oslo, Norway; Oslo University Hospital (M.W.-H.), Department of Neurology, Oslo, Norway; Department of Clinical Neuroscience (T.O.), Karolinska Instituet, Stockholm, Sweden; Department of Clinical Neuroscience (I.K.), Karolinska Institutet, Stockholm, Sweden; Southern California Permanente Medical Group/Kaiser Permanente (A.M.L.-G.), Department of Neurology, Los Angeles, CA; and Institute of Environmental Medicine (L.A.), Karolinska Institutet and Centre for Occupational and Environmental Medicine, Region Stockholm, Stockholm, Sweden.

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http://dx.doi.org/10.1212/NXI.0000000000000898DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7673284PMC
November 2020

Towards standardization guidelines for in silico approaches in personalized medicine.

J Integr Bioinform 2020 Jul 24;17(2-3). Epub 2020 Jul 24.

Medical Informatics Laboratory, Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.

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http://dx.doi.org/10.1515/jib-2020-0006DOI Listing
July 2020

Smoking and Epstein-Barr virus infection in multiple sclerosis development.

Sci Rep 2020 07 3;10(1):10960. Epub 2020 Jul 3.

Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1038/s41598-020-67883-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7335184PMC
July 2020

Inflammation-related plasma and CSF biomarkers for multiple sclerosis.

Proc Natl Acad Sci U S A 2020 06 26;117(23):12952-12960. Epub 2020 May 26.

Neuroimmunology Unit, Center of Molecular Medicine, Department of Clinical Neuroscience, Karolinska University Hospital, Karolinska Institutet, SE-171 77 Stockholm, Sweden;

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http://dx.doi.org/10.1073/pnas.1912839117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7293699PMC
June 2020

Plasma neurofilament light levels are associated with risk of disability in multiple sclerosis.

Neurology 2020 06 20;94(23):e2457-e2467. Epub 2020 May 20.

From the Department of Clinical Neuroscience (A.M., P.S., M.K., F.P., T.O., I.K.), The Karolinska Neuroimmunology & Multiple Sclerosis Centre, Karolinska Institutet; Centre for Molecular Medicine (A.M., P.S., M.K., F.P., T.O., I.K.), Karolinska University Hospital, Stockholm, Sweden; Departments of Medicine, Biomedicine, and Clinical Research (D.L., C.B., Z.M., L.K., J.K.), Neurologic Clinic and Policlinic, University Hospital Basel, University of Basel; Clinical Trial Unit (P.B.), Department of Clinical Research, University Hospital Basel, University of Switzerland; Institution of Neuroscience and Physiology (J.L.), Sahlgrenska Academy, University of Gothenburg, Gothenburg; Institute of Environmental Medicine (L.A.), Karolinska Institutet, Stockholm; and Centre for Occupational and Environmental Medicine (L.A.), Stockholm County Council, Sweden.

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http://dx.doi.org/10.1212/WNL.0000000000009571DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7455371PMC
June 2020

Low fish consumption is associated with a small increased risk of MS.

Neurol Neuroimmunol Neuroinflamm 2020 05 10;7(3). Epub 2020 Apr 10.

From the Department of Clinical Neuroscience (A.K.H., T.O., I.K., J.H.), Institute of Environmental Medicine (A.K.H., L.A.), Center for Molecular Medicine (T.O., I.K., J.H.), Karolinska Institutet, Stockholm, Sweden; and Centre for Occupational and Environmental Medicine (L.A.), Region Stockholm, Stockholm, Sweden.

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http://dx.doi.org/10.1212/NXI.0000000000000717DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7176247PMC
May 2020

Blood neurofilament light levels segregate treatment effects in multiple sclerosis.

Neurology 2020 03 11;94(11):e1201-e1212. Epub 2020 Feb 11.

From the Department of Medicine Solna, Clinical Epidemiology Division (B.D.), The Karolinska Neuroimmunology & Multiple Sclerosis Centre, Department of Clinical Neuroscience (A.M., I.K., T.O., F.P.), and Institute of Environmental Medicine (L.A.), Karolinska Institutet; Centre for Molecular Medicine (A.M., I.K., T.O., F.P.), Karolinska University Hospital, Stockholm, Sweden; Neurologic Clinic and Policlinic, Departments of Medicine, Biomedicine, and Clinical Research (C.B., Z.M., L.K., D.L., J.K.), and Clinical Trial Unit, Department of Clinical Research (P.B.), University Hospital Basel, University of Basel, Switzerland; Sanofi Genzyme (J.A.T.), Stockholm, Sweden; Biogen (T.P., B.C.K.), Cambridge, MA; Department of Neurology, Medical Faculty (B.C.K.), Heinrich-Heine University, Duesseldorf, Germany; and Institution of Neuroscience and Physiology (J.L.), Sahlgrenska Academy, University of Gothenburg, Sweden.

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http://dx.doi.org/10.1212/WNL.0000000000009097DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7387108PMC
March 2020

Confounding effect of blood volume and body mass index on blood neurofilament light chain levels.

Ann Clin Transl Neurol 2020 01 1;7(1):139-143. Epub 2020 Jan 1.

Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1002/acn3.50972DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6952306PMC
January 2020

Low sun exposure increases multiple sclerosis risk both directly and indirectly.

J Neurol 2020 Apr 17;267(4):1045-1052. Epub 2019 Dec 17.

Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1007/s00415-019-09677-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7109160PMC
April 2020

A Gene-Environment Interaction Between Smoking and Gene polymorphisms Provides a High Risk of Two Subgroups of Sarcoidosis.

Sci Rep 2019 12 9;9(1):18633. Epub 2019 Dec 9.

Division of Rheumatology, Department of Medicine Solna, Karolinska Institutet, Karolinska University Hospital, SE-171 76, Stockholm, Sweden.

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http://dx.doi.org/10.1038/s41598-019-54612-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6901455PMC
December 2019

Genome-wide association study of panic disorder reveals genetic overlap with neuroticism and depression.

Mol Psychiatry 2019 Nov 11. Epub 2019 Nov 11.

Centre for Human Genetics, University of Marburg, Marburg, Germany.

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http://dx.doi.org/10.1038/s41380-019-0590-2DOI Listing
November 2019

Retinal nerve fiber layer thickness associates with cognitive impairment and physical disability in multiple sclerosis.

Mult Scler Relat Disord 2019 Nov 26;36:101414. Epub 2019 Sep 26.

Unit of Optometry, Department of Clinical Neuroscience, Karolinska Institutet, Box 8056, S-104 20 Stockholm, Sweden.

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http://dx.doi.org/10.1016/j.msard.2019.101414DOI Listing
November 2019

The influence of human leukocyte antigen-DRB1*15:01 and its interaction with smoking in MS development is dependent on DQA1*01:01 status.

Mult Scler 2020 Nov 1;26(13):1638-1646. Epub 2019 Oct 1.

Institute of Environmental Medicine, Karolinska Institute, Stockholm, Sweden.

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http://dx.doi.org/10.1177/1352458519877685DOI Listing
November 2020

IL-22 Binding Protein Promotes the Disease Process in Multiple Sclerosis.

J Immunol 2019 08 10;203(4):888-898. Epub 2019 Jul 10.

Neuroimmunology Unit, Department of Clinical Neuroscience, Center for Molecular Medicine, Karolinska Institutet, 17177 Stockholm, Sweden.

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http://dx.doi.org/10.4049/jimmunol.1900400DOI Listing
August 2019

Factors associated with and long-term outcome of benign multiple sclerosis: a nationwide cohort study.

J Neurol Neurosurg Psychiatry 2019 07 1;90(7):761-767. Epub 2019 Mar 1.

The Karolinska Neuroimmunology & Multiple Sclerosis Centre, Centre for Molecular Medicine, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden

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http://dx.doi.org/10.1136/jnnp-2018-319913DOI Listing
July 2019

Familial risk of early- and late-onset multiple sclerosis: a Swedish nationwide study.

J Neurol 2019 Feb 21;266(2):481-486. Epub 2018 Dec 21.

Centre for Molecular Medicine, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.

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http://link.springer.com/10.1007/s00415-018-9163-6
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http://dx.doi.org/10.1007/s00415-018-9163-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6373346PMC
February 2019

The association between multiple sclerosis and pain medications.

Pain 2019 Feb;160(2):424-432

Centre for Pharmacoepidemiology, Department of Medicine, Solna, Karolinska Institutet, Stockholm, Sweden.

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http://Insights.ovid.com/crossref?an=00006396-900000000-9882
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http://dx.doi.org/10.1097/j.pain.0000000000001429DOI Listing
February 2019

Organic solvents and MS susceptibility: Interaction with MS risk HLA genes.

Neurology 2018 07 3;91(5):e455-e462. Epub 2018 Jul 3.

From the Department of Clinical Neuroscience and Institute of Environmental Medicine (A.K.H., L.A.), and Department of Clinical Neuroscience and Center for Molecular Medicine (I.K., T.O.), Karolinska Institutet, Stockholm; Mathematical Statistics (O.H.), Stockholm University, Sweden; UCL/Farr Institute of Health Informatics Research (M.K.), London, UK; and Centre for Occupational and Environmental Medicine (L.A.), Stockholm County Council, Sweden.

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http://dx.doi.org/10.1212/WNL.0000000000005906DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6093765PMC
July 2018

Smoking induces DNA methylation changes in Multiple Sclerosis patients with exposure-response relationship.

Sci Rep 2017 11 6;7(1):14589. Epub 2017 Nov 6.

Department of Clinical Neuroscience, Center for Molecular Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.

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http://dx.doi.org/10.1038/s41598-017-14788-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5674007PMC
November 2017

Sex influences eQTL effects of SLE and Sjögren's syndrome-associated genetic polymorphisms.

Biol Sex Differ 2017 10 25;8(1):34. Epub 2017 Oct 25.

Unit of Experimental Rheumatology, Department of Medicine, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1186/s13293-017-0153-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5657123PMC
October 2017

Multiple sclerosis treatment effects on plasma cytokine receptor levels.

Clin Immunol 2018 02 21;187:15-25. Epub 2017 Sep 21.

Department of Clinical Neuroscience and Centrum for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden. Electronic address:

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http://dx.doi.org/10.1016/j.clim.2017.08.023DOI Listing
February 2018

Plasma neurofilament light chain levels in patients with MS switching from injectable therapies to fingolimod.

Mult Scler 2018 07 19;24(8):1046-1054. Epub 2017 Jun 19.

Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden/Department of Neurology, Karolinska University Hospital Solna, Stockholm, Sweden.

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http://dx.doi.org/10.1177/1352458517715132DOI Listing
July 2018

Overexpression of the Cytokine BAFF and Autoimmunity Risk.

N Engl J Med 2017 04;376(17):1615-1626

From Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche Monserrato (M.S., V.O., M.L.I., M. Pitzalis, M. Pala, C.S., V.F., M.F., M. Deiana, I.A., E.P., A. Mulas, M.G.P., M. Lobina, S.L., Mara Marongiu, V.S., Michele Marongiu, G.S., F.B., A. Maschio, F.D., M. Dei, F.V., S.O., A.A., M.B.W., A. Meloni, S. Sanna, E.F., M.Z., F.C.), Center for Advanced Studies, Research, and Development in Sardinia, Parco Scientifico e Tecnologico della Sardegna (I.Z., M.F., R.C., G. Cuccuru), Struttura Complessa Disciplina di Ematologia e Centro Trapianto Cellule Staminali Emopoietiche Wilma Deplano, Ospedale Oncologico di Riferimento Regionale Armando Businco (M. Pani), Dipartimento di Sanità Pubblica, Medicina Clinica e Molecolare, Università di Cagliari (E.C., J.F., G. Coghe, L.L., G. Fenu), Azienda Ospedaliera Brotzu, S.C. Neurologia (P.F., M. Melis), Division of Rheumatology, University and University Hospital of Cagliari (M. Piga, A. Mathieu), Department of Medical Sciences M. Aresu, University of Cagliari (D.F., S.D.G., M.G.M.), Azienda Ospedaliera Brotzu, U.S. Gastroenterologia Pediatrica Ospedale Pediatrico Microcitemico A. Cao (M.C.), and Nephrology, Dialysis, and Transplantation Unit, Giuseppe Brotzu Hospital (A.P.), Cagliari, Dipartimento di Scienze Biomediche, Università degli Studi di Sassari (M.F., F.P., F.C.), Unit of Neurology, Department of Clinical and Experimental Medicine, University of Sassari (G. Farina, G.R.), and Servizio Trasfusionale (M.A.S.) and Clinica Medica (A.D.), Azienda Ospedaliero Universitaria di Sassari, Sassari, Neurology B, Department of Neurological, Biomedical, and Movement Sciences, University of Verona, Verona (G. Farina), Department of Health Sciences, Interdisciplinary Research Center of Autoimmune Diseases, University of Eastern Piedmont, Novara (N.B., S.D.), SC Neurologia, Dipartimento di Scienze Mediche, Istituti di Ricovero e Cura a Carattere Scientifico (IRCCS) Casa Sollievo della Sofferenza, San Giovanni Rotondo (M. Leone), Don C. Gnocchi Foundation IRCCS (F.R.G.), and Referral Center for Systemic Autoimmune Diseases Fondazione IRCCS Cá Granda Ospedale Maggiore Policlinico and University of Milan (M. Marchini), Milan, and Dipartimento di Scienze Cliniche e Molecolari, Università Politecnica delle Marche e Ospedali Riuniti, Ancona (M.G.D.) - all in Italy; Laboratory of Genetics and Genomics, National Institute on Aging, National Institutes of Health, Baltimore (M.L.I., M.G., D.S.); the Department of Clinical Neurosciences (M.B., S. Sawcer) and JDRF-Wellcome Trust Diabetes and Inflammation Laboratory, National Institute for Health Research Cambridge Biomedical Research Centre, Cambridge Institute for Medical Research (J.A.T.), University of Cambridge, Cambridge, United Kingdom; Department of Clinical Neuroscience, Karolinska Institutet at Karolinska University Hospital Solna (I.K., I.L.B., T.O., J.H.), Institute of Environmental Medicine (L.A.) and Institute of Environmental Medicine, Unit of Immunology and Chronic Disease (M.E.A.R.), Karolinska Institute, and Center for Occupational and Environmental Medicine, Stockholm County Council (L.A.), Stockholm; Department of Functional Biology, University of Oviedo, Oviedo (A.S.), Rheumatology Department, Hospital Universitario 12 de Octubre, Madrid (P.E.C.), Department of Internal Medicine, Hospital Universitario Virgen del Rocío, Seville (M.J.C.-P.), Laboratorio de Investigacion 10 and Rheumatology Unit, Instituto de Investigacion Sanitaria-Hospital Clinico Universitario de Santiago, Santiago de Compostela (A.G.), and Centro de Genómica e Investigación Oncológica, Pfizer-Universidad de Granada-Junta de Andalucía, Granada (M.E.A.R.) - all in Spain; Department of Human Genetics, University of Chicago, Chicago (J.H.M., J.N.); Centro Hospitalar do Porto-Hospital Santo Antonio and Unit for Multidisciplinary Research in Biomedicine-Unidade Multidisciplinar de Investigação Biomédica, Porto, Portugal (B.M.S.); Departments of Pathology and Genetics, Stanford University, Stanford, CA (S.B.M.); and Center for Statistical Genetics, University of Michigan, Ann Arbor (G.R.A.).

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http://dx.doi.org/10.1056/NEJMoa1610528DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5605835PMC
April 2017

Evidence for a causal relationship between low vitamin D, high BMI, and pediatric-onset MS.

Neurology 2017 Apr 29;88(17):1623-1629. Epub 2017 Mar 29.

From the Division of Epidemiology, School of Public Health (M.A.G., X.S., E.X., H.Q., D.Q., C.M., L.F.B.), and Computational Biology Graduate Group (B.R.), University of California, Berkeley; Department of Clinical Neuroscience and Center for Molecular Medicine (P.S.), Karolinska Institutet at Karolinska University Hospital, Stockholm, Sweden; Department of Neurology (J.S.G., E.W.) and Regional Pediatric MS Center, Neurology (J.H., S.C.), University of California, San Francisco; Partners Pediatric Multiple Sclerosis Center (T.C.), Massachusetts General Hospital for Children, Boston; Division of Neurology (A.W.), Children's Hospital of Philadelphia, PA; Blue Bird Circle Multiple Sclerosis Center (T.L.), Baylor College of Medicine, Houston, TX; Children's Hospital Colorado (T.S.), University of Colorado, Denver; Lourie Center for Pediatric Multiple Sclerosis (A.B., L.K.), Stony Brook Children's Hospital, NY; Department of Neurology (B.G.), University of Texas Southwestern, Dallas; Pediatric Multiple Sclerosis Center (B.W.-G.), Jacobs Neurological Institute, SUNY Buffalo, NY; Pediatric MS Center at Loma Linda University Children's Hospital (G.A.), CA; Mayo Clinic's Pediatric Multiple Sclerosis Center (J.M.T., M.R.), Rochester, MN; University of Alabama Center for Pediatric-onset Demyelinating Disease (J.N., Y.H.), Children's Hospital of Alabama, Birmingham; Department of Pediatric Neurology (J.R.), Northwestern Feinberg School of Medicine, Chicago, IL; Primary Children's Hospital (M.C.), University of Utah, Salt Lake City; Boston Children's Hospital (M.G., L.B.), MA; Pediatric-onset Demyelinating Diseases and Autoimmune Encephalitis Center (S.M.), St. Louis Children's Hospital, Washington University School of Medicine, MO; Children's National Medical Center (I.K.), Washington, DC; Departments of Neurology (J.R.) and Pediatrics (S.R., T.C.C.), University of Utah School of Medicine, Salt Lake City; Kaiser Permanente Division of Research (L.S., C.S., L.F.B.), Oakland, CA; Institute of Environmental Medicine (J.H., M.B., A.H., T.O., I.K., L.A.), Karolinska Institutet; Centre for Occupational and Environmental Medicine (L.A.), Stockholm County Council, Stockholm, Sweden; and Research Program on Genes, Environment and Health (C.S.), Kaiser Permanente, Oakland, CA.

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http://dx.doi.org/10.1212/WNL.0000000000003849DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5405763PMC
April 2017

DNA methylation mediates genotype and smoking interaction in the development of anti-citrullinated peptide antibody-positive rheumatoid arthritis.

Arthritis Res Ther 2017 03 29;19(1):71. Epub 2017 Mar 29.

Department of Biochemistry and Molecular Biology, The Ministry of Education Key Laboratory of Metabolism and Molecular Medicine, School of Basic Medical Sciences, Fudan University, West Building 13, 130 Dong An Road, Shanghai, China.

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http://dx.doi.org/10.1186/s13075-017-1276-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5372280PMC
March 2017

Mendelian randomization shows a causal effect of low vitamin D on multiple sclerosis risk.

Neurol Genet 2016 Oct 13;2(5):e97. Epub 2016 Sep 13.

Computational Biology Graduate Group (B.R.), Division of Epidemiology (M.G., A.M., X.S., H.Q., L.F.B.), School of Public Health, University of California, Berkeley; Institute of Environmental Medicine (M.B., A.K.H., L.A.), Karolinska Institutet, Stockholm, Sweden; Kaiser Permanente Division of Research (L.S., C.S., L.F.B.), Research Program on Genes, Environment, and Health (C.S.), Kaiser Permanente, Oakland, CA; Department of Clinical Neuroscience and Center for Molecular Medicine (J.L., A.G., T.O., J.H., I.K.), Karolinska Institutet at Karolinska University Hospital, Stockholm, Sweden; Department of Epidemiology and Biostatistics (M.M.G.), University of California, San Francisco; and Centre for Occupational and Environmental Medicine (L.A.), Stockholm County Council, Sweden.

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http://dx.doi.org/10.1212/NXG.0000000000000097DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5022843PMC
October 2016

A significant risk locus on 19q13 for bipolar disorder identified using a combined genome-wide linkage and copy number variation analysis.

BioData Min 2015 18;8:42. Epub 2015 Dec 18.

Neuroimmunology Unit, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1186/s13040-015-0076-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4683747PMC
December 2015

Interaction between passive smoking and two HLA genes with regard to multiple sclerosis risk.

Int J Epidemiol 2014 Dec 15;43(6):1791-8. Epub 2014 Oct 15.

Institute of Environmental Medicine, and Neuroimmunology Unit, Karolinska Institutet, Stockholm, Sweden, Division of Epidemiology, School of Public Health, University of California, Berkeley, CA, USA, Kaiser Permanente Division of Research, Oakland, CA, USA and Neuroimmunology Unit, Karolinska Institutet at Karolinska University Hospital, Solna, Sweden.

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http://dx.doi.org/10.1093/ije/dyu195DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4276064PMC
December 2014

Multiple sclerosis-associated IL2RA polymorphism controls GM-CSF production in human TH cells.

Nat Commun 2014 Oct 3;5:5056. Epub 2014 Oct 3.

Institute of Experimental Immunology, University of Zurich, Winterthurerstrasse 190, Zurich 8052, Switzerland.

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http://dx.doi.org/10.1038/ncomms6056DOI Listing
October 2014

Obesity during childhood and adolescence increases susceptibility to multiple sclerosis after accounting for established genetic and environmental risk factors.

Obes Res Clin Pract 2014 Sep-Oct;8(5):e435-47. Epub 2014 Mar 6.

Division of Epidemiology, Genetic Epidemiology and Genomics Laboratory, School of Public Health, University of California, Berkeley, CA, United States; Kaiser Permanente Division of Research, Oakland, CA, United States. Electronic address:

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http://dx.doi.org/10.1016/j.orcp.2014.01.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4180039PMC
May 2015

Fine mapping analysis confirms and strengthens linkage of four chromosomal regions in familial hypospadias.

Eur J Hum Genet 2015 Apr 2;23(4):516-22. Epub 2014 Jul 2.

1] Department of Women's and Children's Health, Center for Molecular Medicine, Karolinska Institutet CMM 02, Karolinska University Hospital, Stockholm, Sweden [2] Department of Pediatric Surgery, Astrid Lindgren Children Hospital, Karolinska University Hospital, Stockholm, Sweden.

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http://dx.doi.org/10.1038/ejhg.2014.129DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4666571PMC
April 2015

HLA-A(∗)02, gender and tobacco smoking, but not multiple sclerosis, affects the IgG antibody response against human herpesvirus 6.

Hum Immunol 2014 Jun 22;75(6):524-30. Epub 2014 Mar 22.

Karolinska Institutet, Department of Clinical Neuroscience, The Multiple Sclerosis Research Group, Center for Molecular Medicine L8:00, 171 76 Stockholm, Sweden. Electronic address:

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http://dx.doi.org/10.1016/j.humimm.2014.03.001DOI Listing
June 2014

Smoking and risk of multiple sclerosis: evidence of modification by NAT1 variants.

Epidemiology 2014 Jul;25(4):605-14

From the aGenetic Epidemiology and Genomics Laboratory, Division of Epidemiology, School of Public Health, University of California, Berkeley, Berkeley, CA; bDivision of Research, Kaiser Permanente, Oakland, CA; cPalm Drive Hospital, Sebastopol, CA; dDepartment of Medicine, Center for Molecular Medicine, Karolinska Institute, Solna, Sweden; eInstitute of Environmental Medicine, Karolinska Institute, Solna, Sweden.

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http://dx.doi.org/10.1097/EDE.0000000000000089DOI Listing
July 2014

Interaction between adolescent obesity and HLA risk genes in the etiology of multiple sclerosis.

Neurology 2014 Mar 5;82(10):865-72. Epub 2014 Feb 5.

From the Institute of Environmental Medicine (A.K.H.), Neuroimmunology Unit, Department of Clinical Neuroscience (I.L.B., I.K.), and the Institute of Environmental Medicine (L.A.), Karolinska Institutet, Stockholm, Sweden; Genetic Epidemiology and Genomics Lab (L.B., M.G.), Division of Epidemiology, School of Public Health, University of California, Berkeley; Kaiser Permanente Division of Research (C.S.), Oakland, CA; Center for Molecular Medicine (I.K.) and Neuroimmunology Unit, Department of Clinical Neuroscience and Center for Molecular Medicine (T.O.), Karolinska Institutet at Karolinska University Hospital, Solna; and Centre for Occupational and Environmental Medicine (L.A.), Stockholm County Council, Sweden.

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http://dx.doi.org/10.1212/WNL.0000000000000203DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3959752PMC
March 2014

Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis.

Authors:
Ashley H Beecham Nikolaos A Patsopoulos Dionysia K Xifara Mary F Davis Anu Kemppinen Chris Cotsapas Tejas S Shah Chris Spencer David Booth An Goris Annette Oturai Janna Saarela Bertrand Fontaine Bernhard Hemmer Claes Martin Frauke Zipp Sandra D'Alfonso Filippo Martinelli-Boneschi Bruce Taylor Hanne F Harbo Ingrid Kockum Jan Hillert Tomas Olsson Maria Ban Jorge R Oksenberg Rogier Hintzen Lisa F Barcellos Cristina Agliardi Lars Alfredsson Mehdi Alizadeh Carl Anderson Robert Andrews Helle Bach Søndergaard Amie Baker Gavin Band Sergio E Baranzini Nadia Barizzone Jeffrey Barrett Céline Bellenguez Laura Bergamaschi Luisa Bernardinelli Achim Berthele Viola Biberacher Thomas M C Binder Hannah Blackburn Izaura L Bomfim Paola Brambilla Simon Broadley Bruno Brochet Lou Brundin Dorothea Buck Helmut Butzkueven Stacy J Caillier William Camu Wassila Carpentier Paola Cavalla Elisabeth G Celius Irène Coman Giancarlo Comi Lucia Corrado Leentje Cosemans Isabelle Cournu-Rebeix Bruce A C Cree Daniele Cusi Vincent Damotte Gilles Defer Silvia R Delgado Panos Deloukas Alessia di Sapio Alexander T Dilthey Peter Donnelly Bénédicte Dubois Martin Duddy Sarah Edkins Irina Elovaara Federica Esposito Nikos Evangelou Barnaby Fiddes Judith Field Andre Franke Colin Freeman Irene Y Frohlich Daniela Galimberti Christian Gieger Pierre-Antoine Gourraud Christiane Graetz Andrew Graham Verena Grummel Clara Guaschino Athena Hadjixenofontos Hakon Hakonarson Christopher Halfpenny Gillian Hall Per Hall Anders Hamsten James Harley Timothy Harrower Clive Hawkins Garrett Hellenthal Charles Hillier Jeremy Hobart Muni Hoshi Sarah E Hunt Maja Jagodic Ilijas Jelčić Angela Jochim Brian Kendall Allan Kermode Trevor Kilpatrick Keijo Koivisto Ioanna Konidari Thomas Korn Helena Kronsbein Cordelia Langford Malin Larsson Mark Lathrop Christine Lebrun-Frenay Jeannette Lechner-Scott Michelle H Lee Maurizio A Leone Virpi Leppä Giuseppe Liberatore Benedicte A Lie Christina M Lill Magdalena Lindén Jenny Link Felix Luessi Jan Lycke Fabio Macciardi Satu Männistö Clara P Manrique Roland Martin Vittorio Martinelli Deborah Mason Gordon Mazibrada Cristin McCabe Inger-Lise Mero Julia Mescheriakova Loukas Moutsianas Kjell-Morten Myhr Guy Nagels Richard Nicholas Petra Nilsson Fredrik Piehl Matti Pirinen Siân E Price Hong Quach Mauri Reunanen Wim Robberecht Neil P Robertson Mariaemma Rodegher David Rog Marco Salvetti Nathalie C Schnetz-Boutaud Finn Sellebjerg Rebecca C Selter Catherine Schaefer Sandip Shaunak Ling Shen Simon Shields Volker Siffrin Mark Slee Per Soelberg Sorensen Melissa Sorosina Mireia Sospedra Anne Spurkland Amy Strange Emilie Sundqvist Vincent Thijs John Thorpe Anna Ticca Pentti Tienari Cornelia van Duijn Elizabeth M Visser Steve Vucic Helga Westerlind James S Wiley Alastair Wilkins James F Wilson Juliane Winkelmann John Zajicek Eva Zindler Jonathan L Haines Margaret A Pericak-Vance Adrian J Ivinson Graeme Stewart David Hafler Stephen L Hauser Alastair Compston Gil McVean Philip De Jager Stephen J Sawcer Jacob L McCauley

Nat Genet 2013 Nov 29;45(11):1353-60. Epub 2013 Sep 29.

1] John P. Hussman Institute for Human Genomics, University of Miami, Miller School of Medicine, Miami, Florida, USA. [2].

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http://dx.doi.org/10.1038/ng.2770DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3832895PMC
November 2013

Soluble IL7Rα potentiates IL-7 bioactivity and promotes autoimmunity.

Proc Natl Acad Sci U S A 2013 May 22;110(19):E1761-70. Epub 2013 Apr 22.

Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3651437PMC
May 2013

Decline of C-peptide during the first year after diagnosis of Type 1 diabetes in children and adolescents.

Diabetes Res Clin Pract 2013 May 22;100(2):203-9. Epub 2013 Mar 22.

Division of Pediatrics, Department of Clinical and Experimental Medicine, Linköping University, and Pediatric Clinic, Östergötland County Council, Linköping, Sweden.

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http://dx.doi.org/10.1016/j.diabres.2013.03.003DOI Listing
May 2013

Changes to anti-JCV antibody levels in a Swedish national MS cohort.

J Neurol Neurosurg Psychiatry 2013 Nov 5;84(11):1199-205. Epub 2013 Mar 5.

Department of Clinical Neuroscience, Center for Molecular Medicine, Karolinska Institutet, , Stockholm, Sweden.

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http://dx.doi.org/10.1136/jnnp-2012-304332DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3812878PMC
November 2013

Serum levels of LIGHT in MS.

Mult Scler 2013 Jun 4;19(7):871-6. Epub 2012 Oct 4.

Department of Neurology, Sahlgrenska Academy at University of Gothenburg, Sweden.

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June 2013

Low serum levels of vitamin D in idiopathic inflammatory myopathies.

Ann Rheum Dis 2013 Apr 19;72(4):512-6. Epub 2012 Sep 19.

Rheumatology Unit, Danderyd's Hospital, Karolinska Institutet, Stockholm 18288, Sweden.

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April 2013

Lack of replication of interaction between EBNA1 IgG and smoking in risk for multiple sclerosis.

Neurology 2012 Sep 29;79(13):1363-8. Epub 2012 Aug 29.

From the Neuroimmunology Unit, Karolinska Institutet, Stockholm, Sweden.

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September 2012

Genetic association with ERAP1 in psoriasis is confined to disease onset after puberty and not dependent on HLA-C*06.

J Invest Dermatol 2013 Feb 30;133(2):411-7. Epub 2012 Aug 30.

Department of Dermatology and Venereology, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.

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http://dx.doi.org/10.1038/jid.2012.280DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3547223PMC
February 2013

Genome-wide linkage analysis in families with infantile hypertrophic pyloric stenosis indicates novel susceptibility loci.

J Hum Genet 2012 Feb 8;57(2):115-21. Epub 2011 Dec 8.

Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.

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February 2012

Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.

Authors:
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Nature 2011 Aug 10;476(7359):214-9. Epub 2011 Aug 10.

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http://dx.doi.org/10.1038/nature10251DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3182531PMC
August 2011

No influence on disease progression of non-HLA susceptibility genes in MS.

J Neuroimmunol 2011 Aug 13;237(1-2):98-100. Epub 2011 Jul 13.

The Multiple Sclerosis Research group, Centre for Molecular Medicine, Department of Clinical neuroscience, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1016/j.jneuroim.2011.05.003DOI Listing
August 2011

Smoking and two human leukocyte antigen genes interact to increase the risk for multiple sclerosis.

Brain 2011 Mar 8;134(Pt 3):653-64. Epub 2011 Feb 8.

Institute of Environmental Medicine, Karolinska Institutet, 171 77 Stockholm, Sweden.

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http://dx.doi.org/10.1093/brain/awq371DOI Listing
March 2011