Publications by authors named "Ingrid Grummt"

93Publications

Analysis of RNA-DNA Triplex Structures In Vitro and In Vivo.

Methods Mol Biol 2020 ;2161:229-246

Division of Molecular Biology of the Cell II, German Cancer Research Center, DKFZ-ZMBH Alliance, Heidelberg, Germany.

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http://dx.doi.org/10.1007/978-1-0716-0680-3_16DOI Listing
January 2020

Stop-and-Go: Dynamics of Nucleolar Transcription During the Cell Cycle.

Epigenet Insights 2019 21;12:2516865719849090. Epub 2019 May 21.

German Cancer Research Centre, DKFZ-ZMBH Alliance, Heidelberg, Germany.

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http://dx.doi.org/10.1177/2516865719849090DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6537492PMC
May 2019

Experimental Approaches to Investigate the Role of Helicase Acetylation in Regulating R-Loop Stability.

Methods Mol Biol 2019 ;1983:237-253

Division of Molecular Biology of the Cell II, German Cancer Research Center (DKFZ), DKFZ-ZMBH Alliance, Heidelberg, Germany.

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http://dx.doi.org/10.1007/978-1-4939-9434-2_14DOI Listing
January 2020

lncRNA KHPS1 Activates a Poised Enhancer by Triplex-Dependent Recruitment of Epigenomic Regulators.

Cell Rep 2019 03;26(11):2904-2915.e4

Molecular Biology of the Cell II, German Cancer Research Center (DKFZ), DKFZ-ZMBH Alliance, 69120 Heidelberg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2019.02.059DOI Listing
March 2019

Detection of RNA-DNA binding sites in long noncoding RNAs.

Nucleic Acids Res 2019 04;47(6):e32

Institute for Computational Genomics, Joint Research Center for Computational Biomedicine, RWTH Aachen Medical Faculty, Aachen 52074, Germany.

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http://dx.doi.org/10.1093/nar/gkz037DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451187PMC
April 2019

Isolation and genome-wide characterization of cellular DNA:RNA triplex structures.

Nucleic Acids Res 2019 03;47(5):2306-2321

Division of Molecular Biology of the Cell II, German Cancer Research Center, DKFZ-ZMBH Alliance, Heidelberg, Germany.

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https://academic.oup.com/nar/advance-article/doi/10.1093/nar
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http://dx.doi.org/10.1093/nar/gky1305DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6411930PMC
March 2019

SIRT7-Dependent Deacetylation of Fibrillarin Controls Histone H2A Methylation and rRNA Synthesis during the Cell Cycle.

Cell Rep 2018 12;25(11):2946-2954.e5

Molecular Biology of the Cell II, German Cancer Research Centre (DKFZ), DKFZ-Zentrum für Molekulare Biologie der Universität Heidelberg (ZMBH) Alliance, 69120 Heidelberg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2018.11.051DOI Listing
December 2018

lncRNA PAPAS tethered to the rDNA enhancer recruits hypophosphorylated CHD4/NuRD to repress rRNA synthesis at elevated temperatures.

Genes Dev 2018 06 15;32(11-12):836-848. Epub 2018 Jun 15.

Division of Molecular Biology of the Cell II, German Cancer Research Center, Deutsches Krebsforschungszentrum-Zentrum für Molekulare Biologie der Universität Heidelberg Alliance, D-69120 Heidelberg, Germany.

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http://genesdev.cshlp.org/lookup/doi/10.1101/gad.311688.118
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http://dx.doi.org/10.1101/gad.311688.118DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6049515PMC
June 2018

Dynamic regulation of nucleolar architecture.

Curr Opin Cell Biol 2018 06 9;52:105-111. Epub 2018 Mar 9.

Molecular Biology of the Cell II, German Cancer Research Center, DKFZ-ZMBH Alliance, Heidelberg, Germany. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S09550674173014
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http://dx.doi.org/10.1016/j.ceb.2018.02.013DOI Listing
June 2018

Purine- and pyrimidine-triple-helix-forming oligonucleotides recognize qualitatively different target sites at the ribosomal DNA locus.

RNA 2018 03 8;24(3):371-380. Epub 2017 Dec 8.

Biochemistry Centre Regensburg (BCR), Universität Regensburg, 93053 Regensburg, Germany.

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http://dx.doi.org/10.1261/rna.063800.117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5824356PMC
March 2018

SIRT7 and the DEAD-box helicase DDX21 cooperate to resolve genomic R loops and safeguard genome stability.

Genes Dev 2017 07 8;31(13):1370-1381. Epub 2017 Aug 8.

Molecular Biology of the Cell II, German Cancer Research Center (DKFZ), DKFZ-Zentrum für Molekulare Biologie der Universität Heidelberg (ZMBH) Alliance, D-69120 Heidelberg, Germany.

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http://dx.doi.org/10.1101/gad.300624.117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5580657PMC
July 2017

Ribosomes Dance to a Daily Rhythm.

Trends Biochem Sci 2017 08 17;42(8):585-587. Epub 2017 Jun 17.

Molecular Biology of the Cell II, German Cancer Research Center, DKFZ-ZMBH Alliance, Heidelberg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.tibs.2017.06.001DOI Listing
August 2017

SIRT7-dependent deacetylation of CDK9 activates RNA polymerase II transcription.

Nucleic Acids Res 2017 03;45(5):2675-2686

Molecular Biology of the Cell II, German Cancer Research Center (DKFZ), DKFZ-ZMBH Alliance, D-69120 Heidelberg, Germany.

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http://dx.doi.org/10.1093/nar/gkx053DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5389538PMC
March 2017

The seven faces of SIRT7.

Transcription 2017 03 9;8(2):67-74. Epub 2017 Jan 9.

a Molecular Biology of the Cell II , German Cancer Research Center (DKFZ), DKFZ-ZMBH Alliance , Heidelberg , Germany.

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http://dx.doi.org/10.1080/21541264.2016.1276658DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5423475PMC
March 2017

Heat shock represses rRNA synthesis by inactivation of TIF-IA and lncRNA-dependent changes in nucleosome positioning.

Nucleic Acids Res 2016 09 1;44(17):8144-52. Epub 2016 Jun 1.

Division of Molecular Biology of the Cell II, German Cancer Research Center, DKFZ-ZMBH Alliance, D-69120 Heidelberg, Germany

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5041454PMC
http://dx.doi.org/10.1093/nar/gkw496DOI Listing
September 2016

lncRNA-Induced Nucleosome Repositioning Reinforces Transcriptional Repression of rRNA Genes upon Hypotonic Stress.

Cell Rep 2016 Mar 18;14(8):1876-82. Epub 2016 Feb 18.

Division of Molecular Biology of the Cell II, German Cancer Research Center, DKFZ-ZMBH Alliance, Im Neuenheimer Feld 581, 69120 Heidelberg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2016.01.073DOI Listing
March 2016

SIRT7-dependent deacetylation of the U3-55k protein controls pre-rRNA processing.

Nat Commun 2016 Feb 12;7:10734. Epub 2016 Feb 12.

Division of Molecular Biology of the Cell II, German Cancer Research Center, DKFZ-ZMBH Alliance, Im Neuenheimer Fed 581, 69120 Heidelberg, Germany.

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http://www.nature.com/articles/ncomms10734
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http://dx.doi.org/10.1038/ncomms10734DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4754350PMC
February 2016

LncRNA Khps1 Regulates Expression of the Proto-oncogene SPHK1 via Triplex-Mediated Changes in Chromatin Structure.

Mol Cell 2015 Nov;60(4):626-36

Division of Molecular Biology of the Cell II, German Cancer Research Center, 69120 Heidelberg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2015.10.001DOI Listing
November 2015

Alu element-containing RNAs maintain nucleolar structure and function.

EMBO J 2015 Nov 13;34(22):2758-74. Epub 2015 Oct 13.

Genome Organization & Function, German Cancer Research Center (DKFZ) Bioquant Center, Heidelberg, Germany

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http://dx.doi.org/10.15252/embj.201591458DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4682651PMC
November 2015

Cooperative Action of Cdk1/cyclin B and SIRT1 Is Required for Mitotic Repression of rRNA Synthesis.

PLoS Genet 2015 May 29;11(5):e1005246. Epub 2015 May 29.

Division of Molecular Biology of the Cell II, German Cancer Research Center, DKFZ-ZMBH Alliance, Heidelberg, Germany.

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http://dx.doi.org/10.1371/journal.pgen.1005246DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4449194PMC
May 2015

A novel RNA binding surface of the TAM domain of TIP5/BAZ2A mediates epigenetic regulation of rRNA genes.

Nucleic Acids Res 2015 May 27;43(10):5208-20. Epub 2015 Apr 27.

Institute of Structural Biology, Helmholtz Zentrum München, Neuherberg D-85764, Germany Biomolecular NMR and Center for Integrated Protein Science Munich (CIPSM), Department Chemie, Technische Universität München, Garching D-85747, Germany

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http://nar.oxfordjournals.org/content/early/2015/04/27/nar.g
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http://nar.oxfordjournals.org/lookup/doi/10.1093/nar/gkv365
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http://dx.doi.org/10.1093/nar/gkv365DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4446428PMC
May 2015

Long noncoding RNA TARID directs demethylation and activation of the tumor suppressor TCF21 via GADD45A.

Mol Cell 2014 Aug 31;55(4):604-14. Epub 2014 Jul 31.

Division of Epigenomics and Cancer Risk Factors, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany; The German Cancer Consortium, 69120 Heidelberg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2014.06.031DOI Listing
August 2014

Quiescence-induced LncRNAs trigger H4K20 trimethylation and transcriptional silencing.

Mol Cell 2014 May 24;54(4):675-82. Epub 2014 Apr 24.

Division of Molecular Biology of the Cell II, German Cancer Research Center, DKFZ-ZMBH Alliance, 69120 Heidelberg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2014.03.032DOI Listing
May 2014

NoRC silences rRNA genes, telomeres, and centromeres.

Cell Cycle 2014 13;13(4):493-4. Epub 2014 Jan 13.

Division of Molecular Biology of the Cell II; German Cancer Research Center; DKFZ-ZMBH Alliance; Heidelberg, Germany.

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http://dx.doi.org/10.4161/cc.27783DOI Listing
April 2015

Repression of RNA polymerase I upon stress is caused by inhibition of RNA-dependent deacetylation of PAF53 by SIRT7.

Mol Cell 2013 Nov;52(3):303-13

Division of Molecular Biology of the Cell II, German Cancer Research Center, DKFZ-ZMBH Alliance, D-69120 Heidelberg, Germany.

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http://dx.doi.org/10.1016/j.molcel.2013.10.010DOI Listing
November 2013

Noisy silence: non-coding RNA and heterochromatin formation at repetitive elements.

Epigenetics 2014 Jan 11;9(1):53-61. Epub 2013 Oct 11.

Division of Molecular Biology of the Cell II; German Cancer Research Center; DKFZ-ZMBH Alliance; Heidelberg, Germany.

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http://dx.doi.org/10.4161/epi.26485DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3928186PMC
January 2014

Chromatin-specific regulation of mammalian rDNA transcription by clustered TTF-I binding sites.

PLoS Genet 2013 12;9(9):e1003786. Epub 2013 Sep 12.

Biochemistry Centre Regensburg (BCR), University of Regensburg, Regensburg, Germany.

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http://dx.doi.org/10.1371/journal.pgen.1003786DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3772059PMC
March 2014

NuRD blocks reprogramming of mouse somatic cells into pluripotent stem cells.

Stem Cells 2013 Jul;31(7):1278-86

Shenzhen Graduate School of Peking University, Shenzhen, China.

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http://dx.doi.org/10.1002/stem.1374DOI Listing
July 2013

Epigenetic control of RNA polymerase I transcription in mammalian cells.

Biochim Biophys Acta 2013 Mar-Apr;1829(3-4):393-404. Epub 2012 Oct 12.

Division of Molecular Biology of the Cell II, German Cancer Research Center, DKFZ-ZMBH Alliance, Heidelberg, Germany.

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http://dx.doi.org/10.1016/j.bbagrm.2012.10.004DOI Listing
July 2013

The chromatin remodeling complex NuRD establishes the poised state of rRNA genes characterized by bivalent histone modifications and altered nucleosome positions.

Proc Natl Acad Sci U S A 2012 May 8;109(21):8161-6. Epub 2012 May 8.

The Education Ministry, Key Laboratory of Cell Proliferation and Differentiation, Peking University, Beijing 100871, China.

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http://dx.doi.org/10.1073/pnas.1201262109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3361413PMC
May 2012

Human Cdc14B promotes progression through mitosis by dephosphorylating Cdc25 and regulating Cdk1/cyclin B activity.

PLoS One 2011 Feb 17;6(2):e14711. Epub 2011 Feb 17.

Molecular Biology of the Cell II, German Cancer Research Centre, DKFZ-ZMBH Alliance, Heidelberg, Germany.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0014711PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3040744PMC
February 2011

A model for the topology of active ribosomal RNA genes.

EMBO Rep 2011 Mar 18;12(3):231-7. Epub 2011 Feb 18.

Science Faculty, Department of Molecular Biology, Nijmegen Centre for Molecular Life Sciences, Radboud University (274), PO Box 9101, Nijmegen 6500 HB, The Netherlands.

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http://dx.doi.org/10.1038/embor.2011.8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3059908PMC
March 2011

Wisely chosen paths--regulation of rRNA synthesis: delivered on 30 June 2010 at the 35th FEBS Congress in Gothenburg, Sweden.

Authors:
Ingrid Grummt

FEBS J 2010 Nov;277(22):4626-39

Division of Molecular Biology of the Cell II, German Cancer Research Center, DKFZ-ZMBH-Alliance, Heidelberg, Germany.

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http://dx.doi.org/10.1111/j.1742-4658.2010.07892.xDOI Listing
November 2010

Interaction of noncoding RNA with the rDNA promoter mediates recruitment of DNMT3b and silencing of rRNA genes.

Genes Dev 2010 Oct;24(20):2264-9

Division of Molecular Biology of the Cell II, German Cancer Research Center, DKFZ-ZMBH Alliance, D-69120 Heidelberg, Germany.

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http://genesdev.cshlp.org/cgi/doi/10.1101/gad.590910
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http://dx.doi.org/10.1101/gad.590910DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2956204PMC
October 2010

DNA sequence encoded repression of rRNA gene transcription in chromatin.

Nucleic Acids Res 2010 Sep 25;38(16):5304-14. Epub 2010 Apr 25.

Institut für Biochemie III, Universität Regensburg, Universitätsstr. 31, 93053 Regensburg, Germany.

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http://dx.doi.org/10.1093/nar/gkq263DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2938192PMC
September 2010

PHF8 activates transcription of rRNA genes through H3K4me3 binding and H3K9me1/2 demethylation.

Nat Struct Mol Biol 2010 Apr 7;17(4):445-50. Epub 2010 Mar 7.

Division of Molecular Biology of the Cell II, German Cancer Research Center, DKFZ-ZMBH Alliance, Heidelberg, Germany.

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http://dx.doi.org/10.1038/nsmb.1778DOI Listing
April 2010

Linking rDNA transcription to the cellular energy supply.

Cell Cycle 2010 Jan 12;9(2):225-6. Epub 2010 Jan 12.

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http://dx.doi.org/10.4161/cc.9.2.10614DOI Listing
January 2010

Intergenic transcripts originating from a subclass of ribosomal DNA repeats silence ribosomal RNA genes in trans.

EMBO Rep 2010 Jan 4;11(1):52-8. Epub 2009 Dec 4.

Division of Molecular Biology of the Cell II, German Cancer Research Center, DKFZ-ZMBH-Alliance, INF 581, 69120 Heidelberg, Germany.

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http://embor.embopress.org/cgi/doi/10.1038/embor.2009.254
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http://dx.doi.org/10.1038/embor.2009.254DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2816622PMC
January 2010

AMP-activated protein kinase adapts rRNA synthesis to cellular energy supply.

Proc Natl Acad Sci U S A 2009 Oct 6;106(42):17781-6. Epub 2009 Oct 6.

Molecular Biology of the Cell II, German Cancer Research Center, DKFZ-ZMBH Alliance, INF 581, D-69120 Heidelberg, Germany.

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http://dx.doi.org/10.1073/pnas.0909873106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2764937PMC
October 2009

Reversible acetylation of the chromatin remodelling complex NoRC is required for non-coding RNA-dependent silencing.

Nat Cell Biol 2009 Aug 5;11(8):1010-6. Epub 2009 Jul 5.

German Cancer Research Center, Division of Molecular Biology of the Cell II, DKFZ-ZMBH Alliance, Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany.

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http://www.nature.com/doifinder/10.1038/ncb1914
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http://dx.doi.org/10.1038/ncb1914DOI Listing
August 2009

Dynamic subcellular partitioning of the nucleolar transcription factor TIF-IA under ribotoxic stress.

Biochim Biophys Acta 2009 Jul 18;1793(7):1191-8. Epub 2009 May 18.

Cellular Biophysics Group, German Cancer Research Center, D-69120 Heidelberg, Germany.

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http://dx.doi.org/10.1016/j.bbamcr.2009.05.004DOI Listing
July 2009

TAF12 recruits Gadd45a and the nucleotide excision repair complex to the promoter of rRNA genes leading to active DNA demethylation.

Mol Cell 2009 Feb;33(3):344-53

Division of Molecular Biology of the Cell II, German Cancer Research Center, DKFZ-ZMBH Alliance, INF 581, D-69120 Heidelberg, Germany.

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http://dx.doi.org/10.1016/j.molcel.2009.01.015DOI Listing
February 2009

TAF12 recruits Gadd45a and the nucleotide excision repair complex to the promoter of rRNA genes leading to active DNA demethylation.

Mol Cell 2009 Feb;33(3):344-53

Division of Molecular Biology of the Cell II, German Cancer Research Center, DKFZ-ZMBH Alliance, INF 581, D-69120 Heidelberg, Germany.

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http://dx.doi.org/10.1016/j.molcel.2009.01.015DOI Listing
February 2009

Proteasomal ATPases are associated with rDNA: the ubiquitin proteasome system plays a direct role in RNA polymerase I transcription.

Biochim Biophys Acta 2008 Dec 6;1779(12):850-9. Epub 2008 Sep 6.

Division of Molecular Biology of the Cell II, German Cancer Research Center, D-69120, Heidelberg, Germany.

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http://dx.doi.org/10.1016/j.bbagrm.2008.08.010DOI Listing
December 2008

The epigenetics of rRNA genes: from molecular to chromosome biology.

Annu Rev Cell Dev Biol 2008 ;24:131-57

Biomedical Research Center, Ninewells Hospital, University of Dundee, Dundee DD1 9SY, United Kingdom.

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http://dx.doi.org/10.1146/annurev.cellbio.24.110707.175259DOI Listing
December 2008

The structure of NoRC-associated RNA is crucial for targeting the chromatin remodelling complex NoRC to the nucleolus.

EMBO Rep 2008 Aug 4;9(8):774-80. Epub 2008 Jul 4.

Division of Molecular Biology of the Cell II, German Cancer Research Center, DKFZ-ZMBH-Alliance, INF 581, D-69120 Heidelberg, Germany.

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http://dx.doi.org/10.1038/embor.2008.109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2515205PMC
August 2008

Phosphorylation by casein kinase 2 facilitates rRNA gene transcription by promoting dissociation of TIF-IA from elongating RNA polymerase I.

Mol Cell Biol 2008 Aug 16;28(16):4988-98. Epub 2008 Jun 16.

Molecular Biology of Cell II, German Cancer Research Center, DKFZ-ZMBH Alliance, D-69120 Heidelberg, Germany.

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http://mcb.asm.org/cgi/doi/10.1128/MCB.00492-08
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http://dx.doi.org/10.1128/MCB.00492-08DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2519707PMC
August 2008

Modulation of RNA polymerase assembly dynamics in transcriptional regulation.

Mol Cell 2008 May;30(4):486-97

National Cancer Institute, Laboratory of Receptor Biology and Gene Expression, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1016/j.molcel.2008.04.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2441649PMC
May 2008

A metabolic throttle regulates the epigenetic state of rDNA.

Cell 2008 May;133(4):577-80

Department of Molecular Biology of the Cell II, German Cancer Research Center, DKFZ-ZMBH Alliance, Im Neuenheimer Feld 581, 69120 Heidelberg, Germany.

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http://dx.doi.org/10.1016/j.cell.2008.04.026DOI Listing
May 2008

Nuclear myosin I acts in concert with polymeric actin to drive RNA polymerase I transcription.

Genes Dev 2008 Feb 29;22(3):322-30. Epub 2008 Jan 29.

Division of Molecular Biology of the Cell II, German Cancer Research Center, D-69120 Heidelberg, Germany.

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http://dx.doi.org/10.1101/gad.455908DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2216692PMC
February 2008

Different epigenetic layers engage in complex crosstalk to define the epigenetic state of mammalian rRNA genes.

Authors:
Ingrid Grummt

Hum Mol Genet 2007 Apr;16 Spec No 1:R21-7

Division of Molecular Biology of the Cell II, German Cancer Research Center, Heidelberg, Germany.

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http://dx.doi.org/10.1093/hmg/ddm020DOI Listing
April 2007

Activation of RNA polymerase I transcription by cockayne syndrome group B protein and histone methyltransferase G9a.

Mol Cell 2007 Aug;27(4):585-95

Division of Molecular Biology of the Cell II, German Cancer Research Center, D-69120 Heidelberg, Germany.

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http://dx.doi.org/10.1016/j.molcel.2007.06.021DOI Listing
August 2007

Death-effector domain-containing protein DEDD is an inhibitor of mitotic Cdk1/cyclin B1.

Proc Natl Acad Sci U S A 2007 Feb 5;104(7):2289-94. Epub 2007 Feb 5.

Division of Molecular Biomedicine for Pathogenesis, Center for Disease Biology and Integrative Medicine, Faculty of Medicine, University of Tokyo, 7-3-1, Hongo, Tokyo 113-0033, Japan.

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http://dx.doi.org/10.1073/pnas.0611167104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1793902PMC
February 2007

Identification of novel functional TBP-binding sites and general factor repertoires.

EMBO J 2007 Feb 1;26(4):944-54. Epub 2007 Feb 1.

Department of Molecular Biology, Nijmegen Centre for Molecular Life Sciences, Radboud University, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1038/sj.emboj.7601550DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1852848PMC
February 2007

Development of a species-specific RNA polymerase I-based shRNA expression vector.

Nucleic Acids Res 2007 7;35(2):e10. Epub 2006 Dec 7.

Max Planck Institute of Psychiatry, Kraepelinstrasse 2-10, D-80804 Munich, Germany.

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http://dx.doi.org/10.1093/nar/gkl1045DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1802596PMC
March 2007

NoRC-dependent nucleosome positioning silences rRNA genes.

EMBO J 2006 Dec 30;25(24):5735-41. Epub 2006 Nov 30.

Division of Molecular Biology of the Cell II, German Cancer Research Center, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany.

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http://dx.doi.org/10.1038/sj.emboj.7601454DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1698900PMC
December 2006

Intergenic transcripts regulate the epigenetic state of rRNA genes.

Mol Cell 2006 May;22(3):351-61

German Cancer Research Center, Division of Molecular Biology of the Cell II, D-69120 Heidelberg, Germany.

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http://dx.doi.org/10.1016/j.molcel.2006.03.028DOI Listing
May 2006

Mammalian Sir2 homolog SIRT7 is an activator of RNA polymerase I transcription.

Genes Dev 2006 May 17;20(9):1075-80. Epub 2006 Apr 17.

Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.

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http://www.genesdev.org/cgi/doi/10.1101/gad.1399706
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http://dx.doi.org/10.1101/gad.1399706DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1472467PMC
May 2006

Acetylation of UBF changes during the cell cycle and regulates the interaction of UBF with RNA polymerase I.

Nucleic Acids Res 2006 31;34(6):1798-806. Epub 2006 Mar 31.

Division of Molecular Biology, Biocenter, Innsbruck Medical University, A-6020 Innsbruck, Austria.

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http://dx.doi.org/10.1093/nar/gkl101DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1421502PMC
April 2006

Actin and myosin as transcription factors.

Authors:
Ingrid Grummt

Curr Opin Genet Dev 2006 Apr 21;16(2):191-6. Epub 2006 Feb 21.

German Cancer Research Center, Division of Molecular Biology of the Cell II, D-69120 Heidelberg, Germany.

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http://dx.doi.org/10.1016/j.gde.2006.02.001DOI Listing
April 2006

Cellular stress and nucleolar function.

Cell Cycle 2005 Aug 20;4(8):1036-8. Epub 2005 Aug 20.

Division of Molecular Biology of the Cell II, German Cancer Research Center, Heidelberg, Germany.

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http://dx.doi.org/10.4161/cc.4.8.1925DOI Listing
August 2005

The PHD finger/bromodomain of NoRC interacts with acetylated histone H4K16 and is sufficient for rDNA silencing.

Curr Biol 2005 Aug;15(15):1434-8

Division of Molecular Biology of the Cell II, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, D-69120 Heidelberg, Germany.

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http://dx.doi.org/10.1016/j.cub.2005.06.057DOI Listing
August 2005

Genetic inactivation of the transcription factor TIF-IA leads to nucleolar disruption, cell cycle arrest, and p53-mediated apoptosis.

Mol Cell 2005 Jul;19(1):77-87

Division of Molecular Biology of the Cell II, German Cancer Research Center, Im Neuenheimer Feld 280, D-69120 Heidelberg, Germany.

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http://dx.doi.org/10.1016/j.molcel.2005.05.023DOI Listing
July 2005

The nucleolus as a stress sensor: JNK2 inactivates the transcription factor TIF-IA and down-regulates rRNA synthesis.

Genes Dev 2005 Apr 1;19(8):933-41. Epub 2005 Apr 1.

Division of Molecular Biology of the Cell II, German Cancer Research Center, D-69120 Heidelberg, Germany.

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http://dx.doi.org/10.1101/gad.333205DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1080132PMC
April 2005

Epigenetic mechanism of rRNA gene silencing: temporal order of NoRC-mediated histone modification, chromatin remodeling, and DNA methylation.

Mol Cell Biol 2005 Apr;25(7):2539-46

German Cancer Research Center, Division of Molecular Biology of the Cell II, Im Neuenheimer Feld 280, D-69120 Heidelberg, Germany.

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http://dx.doi.org/10.1128/MCB.25.7.2539-2546.2005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1061655PMC
April 2005

The chromatin remodeling complex NoRC controls replication timing of rRNA genes.

EMBO J 2005 Jan 2;24(1):120-7. Epub 2004 Dec 2.

Division of Molecular Biology of the Cell II, German Cancer Research Center, Heidelberg, Germany.

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http://dx.doi.org/10.1038/sj.emboj.7600492DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC544905PMC
January 2005

Nuclear actin and myosin I are required for RNA polymerase I transcription.

Nat Cell Biol 2004 Dec 21;6(12):1165-72. Epub 2004 Nov 21.

Department of Cell Ultrastructure and Molecular Biology, Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, Prague 14220, Czech Republic.

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http://dx.doi.org/10.1038/ncb1190DOI Listing
December 2004

The chromatin remodeling complex NoRC and TTF-I cooperate in the regulation of the mammalian rRNA genes in vivo.

Nucleic Acids Res 2004 3;32(14):4091-9. Epub 2004 Aug 3.

Adolf Butenandt Institut, Molekularbiologie, Ludwig-Maximilians-Universität München, Schillerstrasse 44, D-80336 München, Germany.

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http://dx.doi.org/10.1093/nar/gkh732DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC514363PMC
August 2004

mTOR-dependent activation of the transcription factor TIF-IA links rRNA synthesis to nutrient availability.

Genes Dev 2004 Feb;18(4):423-34

Division of Molecular Biology of the Cell II, German Cancer Research Center, D-69120 Heidelberg, Germany.

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http://dx.doi.org/10.1101/gad.285504DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC359396PMC
February 2004

Epigenetic silencing of RNA polymerase I transcription.

Nat Rev Mol Cell Biol 2003 Aug;4(8):641-9

Division of Molecular Biology of the Cell II, German Cancer Research Center, D-69120 Heidelberg, Germany.

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http://dx.doi.org/10.1038/nrm1171DOI Listing
August 2003

Life on a planet of its own: regulation of RNA polymerase I transcription in the nucleolus.

Authors:
Ingrid Grummt

Genes Dev 2003 Jul;17(14):1691-702

Division of Molecular Biology of the Cell II, German Cancer Research Center, D-69120 Heidelberg, Germany.

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http://dx.doi.org/10.1101/gad.1098503RDOI Listing
July 2003

ERK-dependent phosphorylation of the transcription initiation factor TIF-IA is required for RNA polymerase I transcription and cell growth.

Mol Cell 2003 Feb;11(2):405-13

Division of Molecular Biology of the Cell II, German Cancer Research Center, D-69120, Heidelberg, Germany.

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http://dx.doi.org/10.1016/s1097-2765(03)00036-4DOI Listing
February 2003

Mechanism of inhibition of RNA polymerase I transcription by DNA-dependent protein kinase.

Biol Chem 2002 Nov;383(11):1683-90

Division of Molecular Biology of the Cell II, German Cancer Research Center, D-69120 Heidelberg, Germany.

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http://dx.doi.org/10.1515/BC.2002.189DOI Listing
November 2002

A kinetic framework for a mammalian RNA polymerase in vivo.

Science 2002 Nov;298(5598):1623-6

National Cancer Institute (NCI), National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1126/science.1076164DOI Listing
November 2002

CSB is a component of RNA pol I transcription.

Mol Cell 2002 Oct;10(4):819-29

Institut de Genetique et de Biologie Moleculaire et Cellulaire (CNRS/INSERM/ULP), F-67404, Illkirch Cedex, France.

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http://dx.doi.org/10.1016/s1097-2765(02)00678-0DOI Listing
October 2002

Multiple interactions between RNA polymerase I, TIF-IA and TAF(I) subunits regulate preinitiation complex assembly at the ribosomal gene promoter.

EMBO Rep 2002 Nov 22;3(11):1082-7. Epub 2002 Oct 22.

Division of Molecular Biology of the Cell II, German Cancer Research Center, D-69120 Heidelberg, Germany.

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http://dx.doi.org/10.1093/embo-reports/kvf212DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1307603PMC
November 2002

The nucleolar remodeling complex NoRC mediates heterochromatin formation and silencing of ribosomal gene transcription.

Nat Genet 2002 Nov 7;32(3):393-6. Epub 2002 Oct 7.

Division of Molecular Biology of the Cell II, German Cancer Research Center, D-69120 Heidelberg, Germany.

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http://dx.doi.org/10.1038/ng1010DOI Listing
November 2002

The chromatin remodeling complex NoRC targets HDAC1 to the ribosomal gene promoter and represses RNA polymerase I transcription.

EMBO J 2002 Sep;21(17):4632-40

Division of Molecular Biology of the Cell II, Deutsches Krebsforschungszentrum, D-69120 Heidelberg, Germany.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC126197PMC
http://dx.doi.org/10.1093/emboj/cdf460DOI Listing
September 2002

Autoantibodies to NOR 90/hUBF: longterm clinical and serological followup in a patient with limited systemic sclerosis suggests an antigen driven immune response.

J Rheumatol 2002 Jul;29(7):1543-7

Division of Rheumatology, Hĵpital Notre-Dame, Centre Hospitalier de l'Université de Montréal, Quebec, Canada.

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July 2002

TFIIH plays an essential role in RNA polymerase I transcription.

Cell 2002 May;109(3):297-306

Division of Molecular Biology of the Cell II, German Cancer Research Center, D-69120, Heidelberg, Germany.

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http://dx.doi.org/10.1016/s0092-8674(02)00729-8DOI Listing
May 2002