Ingrid E Wertz

Ingrid E Wertz

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Ingrid E Wertz

Ingrid E Wertz

Publications by authors named "Ingrid E Wertz"

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35Publications

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Structurally-defined deubiquitinase inhibitors provide opportunities to investigate disease mechanisms.

Drug Discov Today Technol 2019 Apr 1;31:109-123. Epub 2019 Apr 1.

Department of Structural Biology, Genentech, Inc. 1 DNA Way, South San Francisco, 94080, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ddtec.2019.02.003DOI Listing
April 2019

From Discovery to Bedside: Targeting the Ubiquitin System.

Cell Chem Biol 2019 02 13;26(2):156-177. Epub 2018 Dec 13.

Department of Discovery Chemistry, Genentech, Inc., South San Francisco, CA 94008, USA.

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http://dx.doi.org/10.1016/j.chembiol.2018.10.022DOI Listing
February 2019

Activity-based probes for the multicatalytic proteasome.

FEBS J 2017 05 7;284(10):1540-1554. Epub 2017 Feb 7.

Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA.

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http://dx.doi.org/10.1111/febs.14016DOI Listing
May 2017

Activity-based probes for the ubiquitin conjugation-deconjugation machinery: new chemistries, new tools, and new insights.

FEBS J 2017 05 10;284(10):1555-1576. Epub 2017 Mar 10.

Early Discovery Biochemistry, Genentech, South San Francisco, CA, USA.

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http://dx.doi.org/10.1111/febs.14039DOI Listing
May 2017

Molecular Understanding of USP7 Substrate Recognition and C-Terminal Activation.

Structure 2016 08 21;24(8):1335-1345. Epub 2016 Jul 21.

Department of Structural Biology, Genentech, South San Francisco, CA 94080, USA. Electronic address:

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http://dx.doi.org/10.1016/j.str.2016.05.020DOI Listing
August 2016

Length Matters: MINDY Is a New Deubiquitinase Family that Preferentially Cleaves Long Polyubiquitin Chains.

Mol Cell 2016 07;63(1):4-6

Departmant of Discovery Oncology, Genentech Inc., 1 DNA Way, South San Francisco, CA, 94080, USA; Department of Early Discovery Biochemistry, Genentech Inc., 1 DNA Way, South San Francisco, CA, 94080, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2016.06.027DOI Listing
July 2016

DUBs, the regulation of cell identity and disease.

Biochem J 2015 Jan;465(1):1-26

*Department of Molecular Oncology, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, U.S.A.

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http://dx.doi.org/10.1042/BJ20140496DOI Listing
January 2015

Toward understanding ubiquitin-modifying enzymes: from pharmacological targeting to proteomics.

Trends Pharmacol Sci 2014 Apr 6;35(4):187-207. Epub 2014 Apr 6.

Department of Early Discovery Biochemistry, Genentech, Inc., 1 DNA Way, M/S 40, South San Francisco, CA 94080, USA. Electronic address:

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http://dx.doi.org/10.1016/j.tips.2014.01.005DOI Listing
April 2014

Conformational stabilization of ubiquitin yields potent and selective inhibitors of USP7.

Nat Chem Biol 2013 Jan 25;9(1):51-8. Epub 2012 Nov 25.

Department of Early Discovery Biochemistry, Genentech Inc., San Francisco, California, USA.

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http://www.nature.com/articles/nchembio.1134
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http://dx.doi.org/10.1038/nchembio.1134DOI Listing
January 2013

It takes two to tango: a new couple in the family of ubiquitin-editing complexes.

Authors:
Ingrid E Wertz

Nat Immunol 2011 Nov 16;12(12):1133-5. Epub 2011 Nov 16.

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http://dx.doi.org/10.1038/ni.2165DOI Listing
November 2011

Ubiquitylation in apoptosis: a post-translational modification at the edge of life and death.

Nat Rev Mol Cell Biol 2011 Jun 23;12(7):439-52. Epub 2011 Jun 23.

Department of Early Discovery Biochemistry, Genentech Inc., South San Francisco, California 94080, USA.

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http://www.nature.com/articles/nrm3143
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http://dx.doi.org/10.1038/nrm3143DOI Listing
June 2011

COP1 is a tumour suppressor that causes degradation of ETS transcription factors.

Nature 2011 May 15;474(7351):403-6. Epub 2011 May 15.

Department of Physiological Chemistry, Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, USA.

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http://dx.doi.org/10.1038/nature10005DOI Listing
May 2011

Ubiquitin binding to A20 ZnF4 is required for modulation of NF-κB signaling.

Mol Cell 2010 Nov;40(4):548-57

Department of Structural Biology, Genentech, Inc, 1 DNA Way, South San Francisco, CA 94080, USA.

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http://dx.doi.org/10.1016/j.molcel.2010.10.009DOI Listing
November 2010

A20: from ubiquitin editing to tumour suppression.

Nat Rev Cancer 2010 May 12;10(5):332-41. Epub 2010 Apr 12.

Department of Structural Biology, Genentech, Inc.1 DNA Way, M/S 40, South San Francisco, CA 94080, USA.

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http://dx.doi.org/10.1038/nrc2775DOI Listing
May 2010

Signaling to NF-kappaB: regulation by ubiquitination.

Cold Spring Harb Perspect Biol 2010 Mar;2(3):a003350

Department of Protein Engineering, Genentech, Inc., South San Francisco, California 94080, USA.

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http://dx.doi.org/10.1101/cshperspect.a003350DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2829959PMC
March 2010

Ubiquitin-mediated regulation of TNFR1 signaling.

Cytokine Growth Factor Rev 2008 Jun-Aug;19(3-4):313-24. Epub 2008 Jun 2.

Department of Protein Engineering, Genentech, Inc., 1 DNA Way, M/S 40, South San Francisco, CA 94080, United States.

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http://linkinghub.elsevier.com/retrieve/pii/S135961010800036
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http://dx.doi.org/10.1016/j.cytogfr.2008.04.014DOI Listing
September 2008

Targeted mass spectrometric strategy for global mapping of ubiquitination on proteins.

Rapid Commun Mass Spectrom 2007 ;21(20):3357-64

Applied Biosystems, Foster City, CA 94404, USA.

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http://dx.doi.org/10.1002/rcm.3227DOI Listing
November 2007

De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-kappaB signalling.

Nature 2004 Aug 18;430(7000):694-9. Epub 2004 Jul 18.

Department of Molecular Oncology, School of Medicine, University of California, Davis, Davis, California 95616, USA.

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http://dx.doi.org/10.1038/nature02794DOI Listing
August 2004

Human De-etiolated-1 regulates c-Jun by assembling a CUL4A ubiquitin ligase.

Science 2004 Feb 22;303(5662):1371-4. Epub 2004 Jan 22.

Department of Molecular Oncology, Genentech, Inc., South San Francisco, CA 94080, USA.

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http://dx.doi.org/10.1126/science.1093549DOI Listing
February 2004