Ingolf Cascorbi

Ingolf Cascorbi

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Ingolf Cascorbi

Publications by authors named "Ingolf Cascorbi"

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Implementation and obstacles of pharmacogenetics in clinical practice: An international survey.

Br J Clin Pharmacol 2019 Sep 7;85(9):2076-2088. Epub 2019 Jul 7.

Department of Pharmacology and Toxicology, Faculty of Medicine, American University of Beirut, Beirut, Lebanon.

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http://dx.doi.org/10.1111/bcp.13999DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6710530PMC
September 2019

Transcriptional and Post-Transcriptional Regulation of Duodenal P-Glycoprotein and MRP2 in Healthy Human Subjects after Chronic Treatment with Rifampin and Carbamazepine.

Mol Pharm 2019 Sep 9;16(9):3823-3830. Epub 2019 Aug 9.

Department of Clinical Pharmacology, Center of Drug Absorption and Transport , University Medicine of Greifswald , Felix-Hausdorff-Straße. 3 , 17487 Greifswald , Germany.

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http://dx.doi.org/10.1021/acs.molpharmaceut.9b00458DOI Listing
September 2019

The Pharmacogenetics of Immune-Modulating Therapy.

Authors:
Ingolf Cascorbi

Adv Pharmacol 2018 30;83:275-296. Epub 2018 Mar 30.

Institute of Experimental and Clinical Pharmacology, University Hospital Schleswig-Holstein, Kiel, Germany. Electronic address:

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http://dx.doi.org/10.1016/bs.apha.2018.02.004DOI Listing
July 2019

Challenges in Neuropharmacology.

Authors:
Ingolf Cascorbi

Clin Pharmacol Ther 2019 May;105(5):1050-1053

Institute of Experimental and Clinical Pharmacology, University Hospital Schleswig-Holstein, Campus Kiel, Germany.

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http://dx.doi.org/10.1002/cpt.1407DOI Listing
May 2019

Implications of genetic variation of common Drug Metabolizing Enzymes and ABC Transporters among the Pakistani Population.

Sci Rep 2019 May 13;9(1):7323. Epub 2019 May 13.

Institute of Experimental and Clinical Pharmacology, Christian Albrechts University Kiel, Hospitalstr. 4, Kiel, 24105, Germany.

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http://dx.doi.org/10.1038/s41598-019-43736-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6514210PMC
May 2019

4th ESPT summer school: precision medicine and personalised health.

Pharmacogenomics 2019 May;20(7):471-474

CANSEARCH Research Laboratory, Department of Paediatrics, Faculty of Medicine, Geneva University, 1205 Geneva, Switzerland.

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http://dx.doi.org/10.2217/pgs-2019-0008DOI Listing
May 2019

Retinoic acid-induced survival effects in SH-SY5Y neuroblastoma cells.

J Cell Biochem 2019 Apr 15;120(4):5974-5986. Epub 2018 Oct 15.

Institute of Experimental and Clinical Pharmacology, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany.

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http://doi.wiley.com/10.1002/jcb.27885
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http://dx.doi.org/10.1002/jcb.27885DOI Listing
April 2019

Interaction of herbal products with prescribed medications: A systematic review and meta-analysis.

Pharmacol Res 2019 03 17;141:397-408. Epub 2019 Jan 17.

Institute of Experimental and Clinical Pharmacology, University Hospital Schleswig-Holstein, Kiel, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.phrs.2019.01.028DOI Listing
March 2019

SIGMA-1 Receptor Gene Variants Affect the Somatosensory Phenotype in Neuropathic Pain Patients.

J Pain 2019 Feb 25;20(2):201-214. Epub 2018 Sep 25.

Division of Neurological Pain Research and Therapy, Department of Neurology, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany.

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http://dx.doi.org/10.1016/j.jpain.2018.08.011DOI Listing
February 2019

Dysregulation of Mucosal Membrane Transporters and Drug-Metabolizing Enzymes in Ulcerative Colitis.

J Pharm Sci 2019 Feb 26;108(2):1035-1046. Epub 2018 Sep 26.

Department of Clinical Pharmacology, Center of Drug Absorption and Transport (C_DAT), University Medicine Greifswald, Greifswald, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.xphs.2018.09.024DOI Listing
February 2019

Plan S: A threat to quality of science?

Science 2019 Feb;363(6426):462

International Union of Basic and Clinical Pharmacology (IUPHAR), Brentwood, TN 37027, USA.

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http://dx.doi.org/10.1126/science.aaw1424DOI Listing
February 2019

The Nomenclature, Definition and Distinction of Types of Shock.

Dtsch Arztebl Int 2018 11;115(45):757-768

Department of Anesthesiology, Intensive and Palliative Care Medicine, Städtisches Klinikum Solingen gGmbH; Department of Anesthesiology and Intensive Care Medicine, University Hospital of Cologne; Institute of Clinical and Experimental Pharmacology at the University Medical Center Schleswig-Holstein, Campus Kiel; Surgical Center/Emergency Department, Department of Anesthesiology and Intensive Care, University; Hospital Carl Gustav Carus, Technische Universität Dresden; Department of Cardiothoracic Surgery, Cardiac Center, University Hospital of Cologne; Department of Orthopedics and Trauma Surgery, Kath. Krankenhaus Hagen gGmbH.

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http://dx.doi.org/10.3238/arztebl.2018.0757DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323133PMC
November 2018

MicroRNA-655-3p regulates Echinacea purpurea mediated activation of ABCG2.

Xenobiotica 2018 Oct 2;48(10):1050-1058. Epub 2017 Nov 2.

b Institute for Experimental and Clinical Pharmacology, University Hospital Schleswig-Holstein , Kiel , Germany , and.

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http://dx.doi.org/10.1080/00498254.2017.1390624DOI Listing
October 2018

The Neurophysiology and Treatment of Motion Sickness.

Dtsch Arztebl Int 2018 10;115(41):687-696

Naval Institute of Maritime Medicine, Kronshagen, Institute of Experimental Medicine, Section Maritime Medicine Christian-Albrechts-Universität, Kiel; Institute of Experimental and Clinical Pharmacology, University Hospital Schleswig-Holstein, Campus Kiel; Clinic for Otorhinolaryngology and Plastic Surgery of the Head and Throat, RWTH Aachen; Department of Neurology, RWTH Aachen; Institute of Physiology Christian- Albrechts-University, Kiel.

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https://www.researchgate.net/publication/282732355_Motion_Si
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https://www.aerzteblatt.de/10.3238/arztebl.2018.0687
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http://dx.doi.org/10.3238/arztebl.2018.0687DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6241144PMC
October 2018

Drug Hypersensitivity.

Dtsch Arztebl Int 2018 Jul;115(29-30):501-512

Institute of Clinical and Experimental Pharmacology at the University Medical Center Schleswig-Holstein, Kiel; Department of Dermatology, Allergology and Venerology, University Medical Center Schleswig-Holstein, Kiel.

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https://www.aerzteblatt.de/10.3238/arztebl.2018.0501
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http://dx.doi.org/10.3238/arztebl.2018.0501DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6121083PMC
July 2018

Significance of Pharmacogenomics in Precision Medicine.

Authors:
Ingolf Cascorbi

Clin Pharmacol Ther 2018 05;103(5):732-735

Institute of Experimental and Clinical Pharmacology, University Hospital Schleswig-Holstein, Campus Kiel, Germany.

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http://dx.doi.org/10.1002/cpt.1052DOI Listing
May 2018

MicroRNA-212/ABCG2-axis contributes to development of imatinib-resistance in leukemic cells.

Oncotarget 2017 Nov 26;8(54):92018-92031. Epub 2017 Sep 26.

Institute of Experimental and Clinical Pharmacology, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany.

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http://dx.doi.org/10.18632/oncotarget.21272DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5696160PMC
November 2017

Short Report: TRPV1-polymorphism 1911 A>G alters capsaicin-induced sensory changes in healthy subjects.

PLoS One 2017 17;12(8):e0183322. Epub 2017 Aug 17.

Division of Neurological Pain Research and Therapy, Department of Neurology, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0183322PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5560710PMC
October 2017

Inflammation: Treatment Progress and Limitations.

Authors:
Ingolf Cascorbi

Clin Pharmacol Ther 2017 Oct;102(4):564-567

Institute of Experimental and Clinical Pharmacology, University Hospital Schleswig-Holstein, Campus Kiel, Germany.

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http://dx.doi.org/10.1002/cpt.792DOI Listing
October 2017

Neuroprotective effects of AT1 receptor antagonists after experimental ischemic stroke: what is important?

Naunyn Schmiedebergs Arch Pharmacol 2017 Sep 2;390(9):949-959. Epub 2017 Jul 2.

Institute of Experimental and Clinical Pharmacology, University Hospital of Schleswig-Holstein, Campus Kiel, Hospitalstraße 4, 24105, Kiel, Germany.

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http://link.springer.com/10.1007/s00210-017-1395-y
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http://dx.doi.org/10.1007/s00210-017-1395-yDOI Listing
September 2017

Neurodegenerative effects of azithromycin in differentiated PC12 cells.

Eur J Pharmacol 2017 Aug 4;809:1-12. Epub 2017 May 4.

Institute of Experimental and Clinical Pharmacology, University Hospital Schleswig-Holstein, Campus Kiel, Arnold-Heller-Strasse 3, 24105 Kiel, Germany.

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http://dx.doi.org/10.1016/j.ejphar.2017.05.002DOI Listing
August 2017

Crosstalk control and limits of physiological c-Jun N-terminal kinase activity for cell viability and neurite stability in differentiated PC12 cells.

Mol Cell Neurosci 2017 07 14;82:12-22. Epub 2017 Apr 14.

Institute of Experimental and Clinical Pharmacology, University Hospital Schleswig-Holstein, Campus Kiel, Arnold-Heller-Strasse 3, 24105 Kiel, Germany.

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http://dx.doi.org/10.1016/j.mcn.2017.04.004DOI Listing
July 2017

Clinically Relevant Multidrug Transporters Are Regulated by microRNAs along the Human Intestine.

Mol Pharm 2017 07 2;14(7):2245-2253. Epub 2017 Jun 2.

Center of Drug Absorption and Transport (C_DAT), Department of Clinical Pharmacology, University Medicine , Greifswald 17489, Germany.

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http://dx.doi.org/10.1021/acs.molpharmaceut.7b00076DOI Listing
July 2017

Advances and challenges in hereditary cancer pharmacogenetics.

Expert Opin Drug Metab Toxicol 2017 Jan 16;13(1):73-82. Epub 2016 Sep 16.

a Institute of Experimental and Clinical Pharmacology , University Hospital Schleswig-Holstein , Kiel , Germany.

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http://dx.doi.org/10.1080/17425255.2017.1233965DOI Listing
January 2017

Pioglitazone induces cell growth arrest and activates mitochondrial apoptosis in human uterine leiomyosarcoma cells by a peroxisome proliferator-activated receptor γ-independent mechanism.

Naunyn Schmiedebergs Arch Pharmacol 2017 Jan 23;390(1):37-48. Epub 2016 Sep 23.

Institute of Experimental and Clinical Pharmacology, University Hospital of Schleswig-Holstein, Campus Kiel, Hospitalstrasse 4, 24105, Kiel, Germany.

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http://dx.doi.org/10.1007/s00210-016-1291-xDOI Listing
January 2017

miRNA-187-3p-Mediated Regulation of the KCNK10/TREK-2 Potassium Channel in a Rat Epilepsy Model.

ACS Chem Neurosci 2016 11 22;7(11):1585-1594. Epub 2016 Sep 22.

Institute of Pharmacology, Toxicology, and Pharmacy, Ludwig-Maximilians-University (LMU) , 80539 Munich, Germany.

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http://dx.doi.org/10.1021/acschemneuro.6b00222DOI Listing
November 2016

Pharmacogenetics and Predictive Testing of Drug Hypersensitivity Reactions.

Front Pharmacol 2016 21;7:396. Epub 2016 Oct 21.

Institute of Experimental and Clinical Pharmacology, University Hospital Schleswig-Holstein Kiel, Germany.

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http://dx.doi.org/10.3389/fphar.2016.00396DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5073094PMC
October 2016

HLA-DRB1*16: 01-DQB1*05: 02 is a novel genetic risk factor for flupirtine-induced liver injury.

Pharmacogenet Genomics 2016 May;26(5):218-24

Departments of aSystems Biology bBiomedical Informatics cThe Herbert Irving Comprehensive Cancer Center, Columbia University, New York, New York dUNC Eshelman School of Pharmacy, Chapel Hill, North Carolina eTarget Sciences, GSK, King of Prussia, Pennsylvania, USA fInstitute for Experimental and Clinical Pharmacology, University Hospital Schleswig-Holstein, Kiel gDrug Commission of the German Medical Association (DCGMA), Berlin, Germany hInstitute of Cellular Medicine, Newcastle University, Newcastle upon Tyne iNational Institute for Health Research (NIHR), Nottingham Digestive Diseases Biomedical Research Unit, Nottingham University Hospital NHS Trust and University of Nottingham, Nottingham, UK jDivision of Gastroenterology and Hepatology, Department of Internal Medicine, The National University Hospital of Iceland, Faculty of Medicine, University of Iceland, Reykjavik, Iceland.

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http://dx.doi.org/10.1097/FPC.0000000000000209DOI Listing
May 2016

Cyclophosphamide treatment-induced leukopenia rates in ANCA-associated vasculitis are influenced by variant CYP450 2C9 genotypes.

Pharmacogenomics 2016 Mar 19;17(4):367-74. Epub 2016 Feb 19.

Institute for Experimental & Clinical Pharmacology, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany.

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http://dx.doi.org/10.2217/pgs.15.176DOI Listing
March 2016

Length variants of the ABCB1 3'-UTR and loss of miRNA binding sites: possible consequences in regulation and pharmacotherapy resistance.

Pharmacogenomics 2016 Mar 19;17(4):327-40. Epub 2016 Feb 19.

Institute of Experimental & Clinical Pharmacology, University Hospital Schleswig-Holstein, Campus Kiel, Germany.

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http://dx.doi.org/10.2217/pgs.15.175DOI Listing
March 2016

Targeting gene expression during the early bone healing period in the mandible: A base for bone tissue engineering.

J Craniomaxillofac Surg 2015 Oct 23;43(8):1452-60. Epub 2015 Jun 23.

Schleswig-Holstein University Hospital, Department of Oral and Maxillofacial Surgery (Head: J. Wiltfang, MD, DMD, PhD), Arnold-Heller-Straße 3, Haus 26, 24105 Kiel, Germany.

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http://dx.doi.org/10.1016/j.jcms.2015.06.015DOI Listing
October 2015

Which Genetic Determinants Should be Considered for Tacrolimus Dose Optimization in Kidney Transplantation? A Combined Analysis of Genes Affecting the CYP3A Locus.

Ther Drug Monit 2015 Jun;37(3):288-95

*Institute of Experimental and Clinical Pharmacology, University Hospital Schleswig-Holstein, Campus Kiel; †Department of Nephrology, University Hospital Rechts der Isar, Technical University of Munich; ‡Department of Nephrology and Hypertension, University Hospital Schleswig-Holstein, Campus Kiel, Germany; §Department of Nephrology, Odense University Hospital, Institute of Molecular Medicine, Institute of Clinical Research, University of Southern Denmark, Odense; and ¶Institute of Medical Informatics and Statistics, University Hospital Schleswig-Holstein, Campus Kiel, Germany.

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http://dx.doi.org/10.1097/FTD.0000000000000142DOI Listing
June 2015

Polymorphisms of the drug transporters ABCB1, ABCG2, ABCC2 and ABCC3 and their impact on drug bioavailability and clinical relevance.

Expert Opin Drug Metab Toxicol 2014 Oct 27;10(10):1337-54. Epub 2014 Aug 27.

Institute of Experimental and Clinical Pharmacology, University Hospital Schleswig-Holstein , Campus Kiel, Arnold-Heller-Str. 3, 24105 Kiel , Germany +49 431 597 3500 ; +49 431 597 3522 ;

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http://www.tandfonline.com/doi/full/10.1517/17425255.2014.95
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http://dx.doi.org/10.1517/17425255.2014.952630DOI Listing
October 2014

Clozapine-induced agranulocytosis is associated with rare HLA-DQB1 and HLA-B alleles.

Nat Commun 2014 Sep 4;5:4757. Epub 2014 Sep 4.

1] Department of Psychiatry, University of North Carolina, Chapel Hill, North Carolina 27599, USA [2] Department of Genetics, University of North Carolina, Chapel Hill, North Carolina 27599, USA [3] Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, SE-171 77 Stockholm, Sweden [4].

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http://dx.doi.org/10.1038/ncomms5757DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4155508PMC
September 2014

Genetic variants may play an important role in mRNA-miRNA interaction: evidence for haplotype-dependent downregulation of ABCC2 (MRP2) by miRNA-379.

Pharmacogenet Genomics 2014 Jun;24(6):283-91

Institute for Experimental and Clinical Pharmacology, University Hospital Schleswig-Holstein, Kiel, Germany.

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https://insights.ovid.com/crossref?an=01213011-201406000-000
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http://dx.doi.org/10.1097/FPC.0000000000000046DOI Listing
June 2014

Functional characterization of protein variants encoded by nonsynonymous single nucleotide polymorphisms in MARC1 and MARC2 in healthy Caucasians.

Drug Metab Dispos 2014 Apr 14;42(4):718-25. Epub 2014 Jan 14.

Department of Pharmaceutical and Medicinal Chemistry, Pharmaceutical Institute, Christian-Albrechts-University of Kiel, Kiel, Germany (G.O., T.K., B.C., A.H.); Department of Plant Biology, Technical University of Braunschweig, Braunschweig, Germany (D.R., F.B., R.-R.M.); and Institute of Experimental and Clinical Pharmacology, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany (C.B., I.C.).

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http://dx.doi.org/10.1124/dmd.113.055202DOI Listing
April 2014

Opportunities and limitations: the value of pharmacogenetics in clinical practice.

Br J Clin Pharmacol 2014 Apr;77(4):583-6

Institute of Cellular Medicine, Newcastle University Medical School, Newcastle upon Tyne, UK.

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http://dx.doi.org/10.1111/bcp.12354DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3971974PMC
April 2014

MicroRNAs and their relevance to ABC transporters.

Br J Clin Pharmacol 2014 Apr;77(4):587-96

Institute of Experimental and Clinical Pharmacology, University Hospital Schleswig-Holstein, Campus Kiel, Germany.

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http://dx.doi.org/10.1111/bcp.12251DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3971975PMC
April 2014

Cellular uptake of imatinib into leukemic cells is independent of human organic cation transporter 1 (OCT1).

Clin Cancer Res 2014 Feb 18;20(4):985-94. Epub 2013 Dec 18.

Authors' Affiliations: Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, and University of Tübingen; Institute of Pharmacy, Department of Pharmacology, University of Tübingen; Department of Clinical Pharmacology, University Hospital Tübingen, Tübingen; Institute of Experimental and Clinical Pharmacology, Second Medical Department, University Hospital Schleswig-Holstein, Campus Kiel; Institute of Anatomy and Cell Biology, University of Würzburg, Würzburg, Germany; and Department of Pharmaceutical Sciences, St Jude Children's Research Hospital, Memphis, Tennessee.

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http://dx.doi.org/10.1158/1078-0432.CCR-13-1999DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3932302PMC
February 2014

Overlapping effects of genetic variation and epigenetics on drug response: challenges of pharmacoepigenomics.

Authors:
Ingolf Cascorbi

Pharmacogenomics 2013 Nov;14(15):1807-9

Institute of Experimental & Clinical Pharmacology, University Hospital Schleswig-Holstein, Arnold-Heller- Str. 3, D-24105 Kiel, Germany.

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http://dx.doi.org/10.2217/pgs.13.194DOI Listing
November 2013

Challenges in pharmacogenetics.

Eur J Clin Pharmacol 2013 May 3;69 Suppl 1:17-23. Epub 2013 May 3.

Institute of Experimental and Clinical Pharmacology, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany.

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http://dx.doi.org/10.1007/s00228-013-1492-xDOI Listing
May 2013

Association of ATP-binding cassette transporter variants with the risk of Alzheimer's disease.

Pharmacogenomics 2013 Apr;14(5):485-94

Institute of Experimental & Clinical Pharmacology, University Hospital Schleswig-Holstein, Arnold-Heller-Str. 3, Bldg 30, D-24105 Kiel, Germany.

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http://dx.doi.org/10.2217/pgs.13.18DOI Listing
April 2013

Correspondence (reply): In Reply.

Authors:
Ingolf Cascorbi

Dtsch Arztebl Int 2013 Feb 22;110(8):133. Epub 2013 Feb 22.

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http://dx.doi.org/10.3238/arztebl.2013.0133bDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3594711PMC
February 2013

Differential expression and functionality of TRPA1 protein genetic variants in conditions of thermal stimulation.

J Biol Chem 2012 Aug 4;287(32):27087-94. Epub 2012 Jun 4.

Institute of Experimental and Clinical Pharmacology, University Hospital Schleswig-Holstein, Campus Kiel, 24105 Kiel, Germany.

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http://dx.doi.org/10.1074/jbc.M112.341776DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3411051PMC
August 2012

miRNAs as mediators of drug resistance.

Epigenomics 2012 Aug;4(4):369-81

Institute of Experimental & Clinical Pharmacology, University Hospital Schleswig-Holstein, Campus Kiel, D-24105 Kiel, Germany.

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http://dx.doi.org/10.2217/epi.12.39DOI Listing
August 2012

Drug interactions--principles, examples and clinical consequences.

Authors:
Ingolf Cascorbi

Dtsch Arztebl Int 2012 Aug 20;109(33-34):546-55; quiz 556. Epub 2012 Aug 20.

Institute of Clinical and Experimental Pharmacology, University Medical Center Schleswig-Holstein, Kiel.

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https://www.aerzteblatt.de/10.3238/arztebl.2012.0546
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http://dx.doi.org/10.3238/arztebl.2012.0546DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3444856PMC
August 2012

Conference Scene: Pharmacogenomic highlights of the DGPT Annual Congress.

Pharmacogenomics 2012 Jul;13(9):997-9

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http://dx.doi.org/10.2217/pgs.12.66DOI Listing
July 2012

Highlights from the latest articles in breast cancer pharmacogenomics.

Pharmacogenomics 2012 Apr;13(6):645-9

Division of Cancer, Department of Surgery & Cancer, Imperial College, Hammersmith Hospital Campus, Du Cane Road, London, W12 0NN, UK.

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https://www.futuremedicine.com/doi/10.2217/pgs.12.20
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http://dx.doi.org/10.2217/pgs.12.20DOI Listing
April 2012

MicroRNA profiling in K-562 cells under imatinib treatment: influence of miR-212 and miR-328 on ABCG2 expression.

Pharmacogenet Genomics 2012 Mar;22(3):198-205

Institute of Experimental and Clinical Pharmacology, University of Kiel, Kiel, Germany.

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http://dx.doi.org/10.1097/FPC.0b013e328350012bDOI Listing
March 2012

OpenVigil--free eyeballs on AERS pharmacovigilance data.

Nat Biotechnol 2012 Feb 8;30(2):137-8. Epub 2012 Feb 8.

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http://dx.doi.org/10.1038/nbt.2113DOI Listing
February 2012

Antimicrobial peptides and proteins of the horse--insights into a well-armed organism.

Vet Res 2011 Sep 2;42:98. Epub 2011 Sep 2.

Institute for Experimental and Clinical Pharmacology, Hospitalstraße 4, University Hospital Schleswig-Holstein, Campus Kiel, 24105 Kiel, Germany.

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http://dx.doi.org/10.1186/1297-9716-42-98DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3179947PMC
September 2011

Down-regulation of ATP-binding cassette C2 protein expression in HepG2 cells after rifampicin treatment is mediated by microRNA-379.

Mol Pharmacol 2011 Aug 3;80(2):314-20. Epub 2011 May 3.

Institute for Experimental and Clinical Pharmacology, University Hospital Schleswig-Holstein, Bldg. 30, Arnold-Heller-Str. 3, D-24105 Kiel, Germany.

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http://dx.doi.org/10.1124/mol.110.070714DOI Listing
August 2011

Clinical implementation of pharmacogenetics: a nonrepresentative explorative survey to participants of WorldPharma 2010.

Pharmacogenomics 2011 Jul;12(7):1051-9

Medical Education Unit, Faculty of Medicine, American University of Beirut, Beirut, Lebanon.

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https://www.futuremedicine.com/doi/10.2217/pgs.11.42
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http://dx.doi.org/10.2217/pgs.11.42DOI Listing
July 2011

Analysis of alternative promoter usage in expression of HSD11B1 including the development of a transcript-specific quantitative real-time PCR method.

Chem Biol Interact 2011 May 6;191(1-3):104-12. Epub 2011 Jan 6.

Institute of Toxicology and Pharmacology for Natural Scientists, University Medical School Schleswig-Holstein, Kiel, Germany.

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http://dx.doi.org/10.1016/j.cbi.2010.12.027DOI Listing
May 2011

P-glycoprotein: tissue distribution, substrates, and functional consequences of genetic variations.

Authors:
Ingolf Cascorbi

Handb Exp Pharmacol 2011 (201):261-83

Institute of Experimental and Clinical Pharmacology, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany.

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http://dx.doi.org/10.1007/978-3-642-14541-4_6DOI Listing
February 2011

Safe and effective medicines for all: is personalized medicine the answer?

Authors:
Ingolf Cascorbi

Expert Rev Clin Pharmacol 2010 Sep;3(5):627-37

Institute for Experimental and Clinical Pharmacology, University Hospital Schleswig-Holstein, Arnold-Heller-Str. 3, Bldg 30, D-24105 Kiel, Germany.

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http://dx.doi.org/10.1586/ecp.10.36DOI Listing
September 2010

The promises of personalized medicine.

Authors:
Ingolf Cascorbi

Eur J Clin Pharmacol 2010 Aug 19;66(8):749-54. Epub 2010 Jun 19.

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http://dx.doi.org/10.1007/s00228-010-0858-6DOI Listing
August 2010

Genotype frequencies of selected drug metabolizing enzymes and ABC drug transporters among breast cancer patients on FAC chemotherapy.

Basic Clin Pharmacol Toxicol 2010 Jul 19;107(1):570-6. Epub 2010 Jan 19.

Ziauddin University, Clifton Campus, Shahra-e-Ghalib, Karachi, Pakistan.

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http://dx.doi.org/10.1111/j.1742-7843.2009.00531.xDOI Listing
July 2010

Pharmacogenetics of ATP-binding cassette transporters and clinical implications.

Methods Mol Biol 2010 ;596:95-121

Institute of Experimental and Clinical Pharmacology, University of Kiel, Kiel, Germany.

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http://dx.doi.org/10.1007/978-1-60761-416-6_6DOI Listing
January 2010

Decreased sigmoidal ABCB1 (P-glycoprotein) expression in ulcerative colitis is associated with disease activity.

Pharmacogenomics 2009 Dec;10(12):1941-53

University Hospital Schleswig-Holstein, Arnold-Heller-Str. 3 (Hs. 30); D-24105 Kiel, Germany.

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http://dx.doi.org/10.2217/pgs.09.128DOI Listing
December 2009

[Hypoglycemic risk of insulinotropic drugs].

Med Monatsschr Pharm 2009 Dec;32(12):453-8

Institut für Experimentelle und Klinische Pharmakologie, Hospitalstrasse 4, 24105 Kiel.

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December 2009

Conference Scene: Pharmacogenomics at the second PharmSciFair 2009: adverse drug reactions and clinical implementation.

Pharmacogenomics 2009 Sep;10(9):1389-91

Utrecht Institute for Pharmaceutical Sciences, Division of Pharmacoepidemiology and Pharmacotherapy, 3508 TB Utrecht, The Netherlands.

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http://dx.doi.org/10.2217/pgs.09.95DOI Listing
September 2009

Regulation's threat to research. A UK problem.

BMJ 2008 Dec 10;337:a2919. Epub 2008 Dec 10.

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http://dx.doi.org/10.1136/bmj.a2919DOI Listing
December 2008

Association of ABCB1 genetic variants 3435C>T and 2677G>T to ABCB1 mRNA and protein expression in brain tissue from refractory epilepsy patients.

Epilepsia 2008 Sep 20;49(9):1555-61. Epub 2008 May 20.

Institute of Pharmacology, University Hospital Schleswig-Holstein, Kiel, Germany.

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http://dx.doi.org/10.1111/j.1528-1167.2008.01661.xDOI Listing
September 2008

Pharmacogenomics in acute coronary syndrome.

Expert Opin Pharmacother 2008 Feb;9(3):363-76

Institute of Pharmacology, University Hospital Schleswig-Holstein, Hospitalstr. 4, D-24105 Kiel, Germany.

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http://dx.doi.org/10.1517/14656566.9.3.363DOI Listing
February 2008

Educating European (junior) doctors for safe prescribing.

Basic Clin Pharmacol Toxicol 2007 Dec 9;101(6):395-400. Epub 2007 Oct 9.

British Pharmacological Society, Clinical Pharmacology Unit, University of Edinburgh, Queens Medical Research Institute, Edinburgh, UK.

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http://dx.doi.org/10.1111/j.1742-7843.2007.00141.xDOI Listing
December 2007

MDR1-P-Glycoprotein (ABCB1) Mediates Transport of Alzheimer's amyloid-beta peptides--implications for the mechanisms of Abeta clearance at the blood-brain barrier.

Brain Pathol 2007 Oct 4;17(4):347-53. Epub 2007 Jul 4.

Department of Pharmacology, Research Center of Pharmacology and Experimental Therapeutics, Ernst-Moritz-Arndt-University, Greifswald, Germany.

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http://dx.doi.org/10.1111/j.1750-3639.2007.00075.xDOI Listing
October 2007

Role of pharmacogenetics of ATP-binding cassette transporters in the pharmacokinetics of drugs.

Authors:
Ingolf Cascorbi

Pharmacol Ther 2006 Nov;112(2):457-73

Institute of Pharmacology, University Hospital Schleswig-Holstein, Hospitalstrasse 4, D-24105 Kiel, Germany.

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http://dx.doi.org/10.1016/j.pharmthera.2006.04.009DOI Listing
November 2006

Genetic basis of toxic reactions to drugs and chemicals.

Authors:
Ingolf Cascorbi

Toxicol Lett 2006 Mar 28;162(1):16-28. Epub 2005 Nov 28.

Institute of Pharmacology, University Hospital Schleswig-Holstein, Hospitalstr. 4, D-24105 Kiel, Germany.

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http://dx.doi.org/10.1016/j.toxlet.2005.10.015DOI Listing
March 2006

The ATP-binding cassette transporter ABCG2 (BCRP), a marker for side population stem cells, is expressed in human heart.

J Histochem Cytochem 2006 Feb 22;54(2):215-21. Epub 2005 Aug 22.

Institut für Pharmakologie, Ernst-Moritz-Arndt-Universität Greifswald, Friedrich-Loeffler-Str. 23d, D-17487 Greifswald, Germany.

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http://dx.doi.org/10.1369/jhc.5A6750.2005DOI Listing
February 2006

A LC-MS/MS method to quantify the novel cholesterol lowering drug ezetimibe in human serum, urine and feces in healthy subjects genotyped for SLCO1B1.

J Chromatogr B Analyt Technol Biomed Life Sci 2006 Jan 8;830(1):143-50. Epub 2005 Nov 8.

Department of Clinical Pharmacology of the Peter Holtz Research Center of Pharmacology and Experimental Therapeutics, University of Greifswald, Germany.

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http://linkinghub.elsevier.com/retrieve/pii/S157002320500806
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http://dx.doi.org/10.1016/j.jchromb.2005.10.034DOI Listing
January 2006

Identification and functional analysis of genetic variants of the human beta-glucuronidase in a German population sample.

Pharmacogenet Genomics 2005 Dec;15(12):875-81

Institute of Pharmacology, Peter Holtz Research Center of Pharmacology and Experimental Therapeutics, Ernst Moritz Arndt-University Greifswald, Germany.

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http://dx.doi.org/10.1097/01213011-200512000-00005DOI Listing
December 2005

Drug-induced agranulocytosis: impact of different fcgamma receptor polymorphisms?

J Clin Psychopharmacol 2005 Oct;25(5):435-40

Institute of Pharmacology, Ernst Moritz Arndt University, Greifswald, Germany.

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http://dx.doi.org/10.1097/01.jcp.0000177551.13714.33DOI Listing
October 2005

Influence of an insertion variant in the 5'UTR of the endothelin-1 gene on orthostatic intolerance.

Am J Med Sci 2005 Oct;330(4):166-71

Division of Occupational Medicine, Medical University of Vienna, Vienna, Austria.

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http://dx.doi.org/10.1097/00000441-200510000-00003DOI Listing
October 2005