Ingebrigt Sylte

Ingebrigt Sylte

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Ingebrigt Sylte

Ingebrigt Sylte

Publications by authors named "Ingebrigt Sylte"

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In Silico Methods for the Discovery of Orthosteric GABA Receptor Compounds.

Molecules 2019 Mar 7;24(5). Epub 2019 Mar 7.

Molecular Pharmacology and Toxicology, Department of Medical Biology, Faculty of Health Sciences, UiT-The Arctic University of Norway, NO-9037 Tromsø, Norway.

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http://dx.doi.org/10.3390/molecules24050935DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6429233PMC
March 2019

Synthesis, molecular modeling and biological evaluation of potent analogs of 2-methoxyestradiol.

Steroids 2018 08 18;136:47-55. Epub 2018 May 18.

Department of Pharmaceutical Chemistry, School of Pharmacy, University of Oslo, PO Box 1068 Blindern, N-0316 Oslo, Norway. Electronic address:

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http://dx.doi.org/10.1016/j.steroids.2018.05.002DOI Listing
August 2018

In Vitro and in Silico Competitive Binding of Brominated Polyphenyl Ether Contaminants with Human and Gull Thyroid Hormone Transport Proteins.

Environ Sci Technol 2018 Feb 16;52(3):1533-1541. Epub 2018 Jan 16.

Ecotoxicology and Wildlife Health Division, Environment and Climate Change Canada, National Wildlife Research Centre, Carleton University, Ottawa, Ontario K1A 0H3, Canada.

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http://dx.doi.org/10.1021/acs.est.7b04617DOI Listing
February 2018

Ligand-guided homology modelling of the GABAB2 subunit of the GABAB receptor.

PLoS One 2017 21;12(3):e0173889. Epub 2017 Mar 21.

Department of Medical Biology, Faculty of Health Sciences, UiT - the Arctic University of Norway, Tromsø, Norway.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0173889PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5360267PMC
August 2017

Specific interactions between zinc metalloproteinase and its inhibitors: Ab initio fragment molecular orbital calculations.

J Mol Graph Model 2017 08 8;75:277-286. Epub 2017 Jun 8.

Department of Computer Science and Engineering, Toyohashi University of Technology, Toyohashi, 441-8580, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.jmgm.2017.05.013DOI Listing
August 2017

Serotonin transporter and receptor ligands with antidepressant activity as neuroprotective and proapoptotic agents.

Pharmacol Rep 2017 Jun 22;69(3):469-478. Epub 2017 Jan 22.

Department of Medical Biology, Faculty of Health Sciences, UiT - The Arctic University of Norway, Tromsø, Norway.

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https://linkinghub.elsevier.com/retrieve/pii/S17341140163016
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http://dx.doi.org/10.1016/j.pharep.2017.01.011DOI Listing
June 2017

Regulation of liver X receptor target genes by 22-functionalized oxysterols. Synthesis, in silico and in vitro evaluations.

Steroids 2017 02 21;118:119-127. Epub 2016 Dec 21.

Department of Pharmaceutical Biosciences, School of Pharmacy, University of Oslo, Oslo, Norway.

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http://dx.doi.org/10.1016/j.steroids.2016.12.003DOI Listing
February 2017

Synthesis, in vitro and in vivo biological evaluation of new oxysterols as modulators of the liver X receptors.

J Steroid Biochem Mol Biol 2017 01 26;165(Pt B):323-330. Epub 2016 Jul 26.

Department of Pharmaceutical Biosciences, School of Pharmacy, University of Oslo, PO Box 1068 Blindern, N-0316 Oslo, Norway. Electronic address:

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http://dx.doi.org/10.1016/j.jsbmb.2016.07.010DOI Listing
January 2017

Synthesis, experimental evaluation and molecular modelling of hydroxamate derivatives as zinc metalloproteinase inhibitors.

Eur J Med Chem 2016 Jan 28;108:141-153. Epub 2015 Nov 28.

Department of Pharmacy, Faculty of Health Sciences, UiT The Arctic University of Norway, NO-9037 Tromsø, Norway.

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http://dx.doi.org/10.1016/j.ejmech.2015.11.019DOI Listing
January 2016

High-level expression of pseudolysin, the extracellular elastase of Pseudomonas aeruginosa, in Escherichia coli and its purification.

Protein Expr Purif 2015 Sep 12;113:79-84. Epub 2015 May 12.

Department of Medical Biology, Faculty of Health Sciences, UiT The Arctic University of Norway, NO-9037 Tromsø, Norway.

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http://dx.doi.org/10.1016/j.pep.2015.05.005DOI Listing
September 2015

Functional Selectivity and Antidepressant Activity of Serotonin 1A Receptor Ligands.

Int J Mol Sci 2015 Aug 7;16(8):18474-506. Epub 2015 Aug 7.

Faculty of Health Sciences, University of Tromsø-The Arctic University of Norway, No-9037 Tromsø, Norway.

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http://dx.doi.org/10.3390/ijms160818474DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4581256PMC
August 2015

Synthesis, biological evaluation and molecular modeling studies of the PPARβ/δ antagonist CC618.

Eur J Med Chem 2015 Apr 5;94:229-36. Epub 2015 Mar 5.

Department of Pharmaceutical Chemistry, School of Pharmacy, University of Oslo, PO BOX 1068, Blindern, N-0316 Oslo, Norway. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2015.03.006DOI Listing
April 2015

Inhibition of pseudolysin and thermolysin by hydroxamate-based MMP inhibitors.

Eur J Med Chem 2015 Jan 18;89:340-8. Epub 2014 Oct 18.

Department of Medical Biology, Faculty of Health Sciences, UiT - The Arctic University of Norway, NO-9037 Tromsø, Norway. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2014.10.009DOI Listing
January 2015

Ligand-directed trafficking of receptor stimulus.

Pharmacol Rep 2014 Dec 26;66(6):1011-21. Epub 2014 Jun 26.

Medical Pharmacology and Toxicology, Department of Medical Biology, Faculty of Health Sciences, University of Tromsø - The Arctic University of Norway, Tromsø, Norway.

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http://dx.doi.org/10.1016/j.pharep.2014.06.006DOI Listing
December 2014

PAC-1 and isatin derivatives are weak matrix metalloproteinase inhibitors.

Biochim Biophys Acta 2014 Oct 18;1840(10):3162-9. Epub 2014 Jul 18.

Department of Medical Biology, Faculty of Health Sciences, UiT-The Arctic University of Norway, 9037 Tromsø, Norway. Electronic address:

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http://dx.doi.org/10.1016/j.bbagen.2014.07.011DOI Listing
October 2014

Comparative molecular dynamic simulations of wild type and Thr114Val mutated Scaptodrosophila lebanonensis alcohol dehydrogenase.

J Biomol Struct Dyn 2014 25;32(3):465-76. Epub 2013 Mar 25.

a Faculty of Health Sciences, Department of Medical Biology , University of Tromsø , NO-9037, Tromsø , Norway .

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http://dx.doi.org/10.1080/07391102.2013.776502DOI Listing
August 2014

Development of new LXR modulators that regulate LXR target genes and reduce lipogenesis in human cell models.

Eur J Med Chem 2014 Mar 11;74:258-63. Epub 2014 Jan 11.

Department of Pharmaceutical Biosciences, School of Pharmacy, University of Oslo, P.O. Box 1068, Blindern, N-0316 Oslo, Norway. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2014.01.003DOI Listing
March 2014

Identification of novel serotonin transporter compounds by virtual screening.

J Chem Inf Model 2014 Mar 26;54(3):933-43. Epub 2014 Feb 26.

Medical Pharmacology and Toxicology, Department of Medical Biology, Faculty of Health Sciences, UiT, The Arctic University of Norway , 9037 Tromsø, Norway.

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http://dx.doi.org/10.1021/ci400742sDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3982395PMC
March 2014

Comparative molecular dynamics simulations of mitogen-activated protein kinase-activated protein kinase 5.

Int J Mol Sci 2014 Mar 19;15(3):4878-902. Epub 2014 Mar 19.

Medical Pharmacology and Toxicology, Department of Medical Biology, Faculty of Health Sciences, UiT the Arctic University of Norway, Tromsø NO-9037, Norway.

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http://www.mdpi.com/1422-0067/15/3/4878
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http://dx.doi.org/10.3390/ijms15034878DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3975429PMC
March 2014

Homology modeling of human γ-butyric acid transporters and the binding of pro-drugs 5-aminolevulinic acid and methyl aminolevulinic acid used in photodynamic therapy.

PLoS One 2013 7;8(6):e65200. Epub 2013 Jun 7.

Department of Cancer Research and Molecular Medicine, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0065200PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3676387PMC
January 2014

Synthesis and initial biological evaluation of new mimics of the LXR-modulator 22(S)-hydroxycholesterol.

Bioorg Med Chem 2014 Jan 5;22(1):643-50. Epub 2013 Nov 5.

Department of Pharmaceutical Chemistry, School of Pharmacy, University of Oslo, PO Box 1068, Blindern, N-0315 Oslo, Norway. Electronic address:

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http://dx.doi.org/10.1016/j.bmc.2013.10.024DOI Listing
January 2014

Homology modeling and ligand docking of Mitogen-activated protein kinase-activated protein kinase 5 (MK5).

Theor Biol Med Model 2013 Sep 14;10:56. Epub 2013 Sep 14.

Medical Pharmacology and Toxicology, Department of Medical Biology, Faculty of Health Sciences, University of Tromsø, Tromsø No-9037, Norway.

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http://dx.doi.org/10.1186/1742-4682-10-56DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3848485PMC
September 2013

Differences in PAR-2 activating potential by king crab (Paralithodes camtschaticus), salmon (Salmo salar), and bovine (Bos taurus) trypsin.

BMC Res Notes 2013 Jul 20;6:281. Epub 2013 Jul 20.

Department of Occupational- and Environmental Medicine, University Hospital North Norway, Tromsø, Norway.

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http://dx.doi.org/10.1186/1756-0500-6-281DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3733831PMC
July 2013

Dipeptide inhibitors of thermolysin and angiotensin I-converting enzyme.

Curr Top Med Chem 2012 ;12(16):1748-62

Medical Pharmacology and Toxicology, Department of Medical Biology, Faculty of Health Sciences, University of Tromsø, 9037 Tromsø, Norway.

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June 2013

An intact eight-membered water chain in drosophilid alcohol dehydrogenases is essential for optimal enzyme activity.

FEBS J 2012 Aug 19;279(16):2940-56. Epub 2012 Jul 19.

Department of Medical Biology, Faculty of Health Sciences, University of Tromsø, Tromsø, Norway.

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http://dx.doi.org/10.1111/j.1742-4658.2012.08675.xDOI Listing
August 2012

Homology modeling of transporter proteins (carriers and ion channels).

Methods Mol Biol 2012 ;857:281-99

Medical Pharmacology and Toxicology, Department of Medical Biology, Faculty of Health Sciences, University of Tromsø, Tromsø, Norway.

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http://dx.doi.org/10.1007/978-1-61779-588-6_12DOI Listing
May 2012

Substrate binding and translocation of the serotonin transporter studied by docking and molecular dynamics simulations.

J Mol Model 2012 Mar 14;18(3):1073-85. Epub 2011 Jun 14.

Medical Pharmacology and Toxicology, Department of Medical Biology, Faculty of Health Sciences, University of Tromsø, N-9037 Tromsø, Norway.

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http://dx.doi.org/10.1007/s00894-011-1133-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3283764PMC
March 2012

Specific interactions and binding energies between thermolysin and potent inhibitors: molecular simulations based on ab initio molecular orbital method.

J Mol Graph Model 2012 Mar 2;33:1-11. Epub 2011 Nov 2.

Department of Computer Science and Engineering, Toyohashi University of Technology, Tempaku-cho, Aichi, Japan.

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http://dx.doi.org/10.1016/j.jmgm.2011.10.006DOI Listing
March 2012

The liver X receptor modulator 22(S)-hydroxycholesterol exerts cell-type specific effects on lipid and glucose metabolism.

J Steroid Biochem Mol Biol 2012 Feb 25;128(3-5):154-64. Epub 2011 Oct 25.

Department of Pharmaceutical Biosciences, School of Pharmacy, University of Oslo, Oslo, Norway.

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http://dx.doi.org/10.1016/j.jsbmb.2011.10.006DOI Listing
February 2012

Molecular mechanism of serotonin transporter inhibition elucidated by a new flexible docking protocol.

Eur J Med Chem 2012 Jan 20;47(1):24-37. Epub 2011 Oct 20.

Medical Pharmacology and Toxicology, Department of Medical Biology, Faculty of Health Sciences, University of Tromsø, N-9037 Tromsø, Norway.

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http://www-ablab.ucsd.edu/pdf/11_sert_ejmc.pdf
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http://linkinghub.elsevier.com/retrieve/pii/S022352341100717
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http://dx.doi.org/10.1016/j.ejmech.2011.09.056DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3357065PMC
January 2012

Synthesis, molecular modeling studies and biological evaluation of fluorine substituted analogs of GW 501516.

Bioorg Med Chem 2011 Dec 17;19(23):6982-8. Epub 2011 Oct 17.

School of Pharmacy, Department of Pharmaceutical Chemistry, University of Oslo, PO BOX 1068, Blindern, N-0316 Oslo, Norway.

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http://dx.doi.org/10.1016/j.bmc.2011.10.020DOI Listing
December 2011

A short update on the structure of drug binding sites on neurotransmitter transporters.

BMC Res Notes 2011 Dec 22;4:559. Epub 2011 Dec 22.

Medical Pharmacology and Toxicology Research Group, Department of Medical Biology, Faculty of Health Sciences, University of Tromsø, 9037 Tromsø, Norway.

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http://dx.doi.org/10.1186/1756-0500-4-559DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3259071PMC
December 2011

Specific interactions and binding free energies between thermolysin and dipeptides: molecular simulations combined with ab initio molecular orbital and classical vibrational analysis.

J Comput Chem 2011 Nov 3;32(14):3047-57. Epub 2011 Aug 3.

Department of Computer Science and Engineering, Toyohashi University of Technology, Tempaku-cho, Aichi 441-8580, Japan.

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http://doi.wiley.com/10.1002/jcc.21887
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http://dx.doi.org/10.1002/jcc.21887DOI Listing
November 2011

Protein binding site analysis by means of structural interaction fingerprint patterns.

Bioorg Med Chem Lett 2011 Nov 14;21(22):6816-9. Epub 2011 Sep 14.

Department of Medicinal Chemistry, Institute of Pharmacology Polish Academy of Sciences, Smetna 12, 31-343 Krakow, Poland.

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http://linkinghub.elsevier.com/retrieve/pii/S0960894X1101262
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http://dx.doi.org/10.1016/j.bmcl.2011.09.027DOI Listing
November 2011

Regulation of matrix metalloproteinase activity in health and disease.

FEBS J 2011 Jan 19;278(1):28-45. Epub 2010 Nov 19.

Department of Medical Biology, Faculty of Health Sciences, University of Tromsø, Norway.

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http://doi.wiley.com/10.1111/j.1742-4658.2010.07920.x
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http://dx.doi.org/10.1111/j.1742-4658.2010.07920.xDOI Listing
January 2011

Synthesis, biological evaluation and molecular modeling of GW 501516 analogues.

Arch Pharm (Weinheim) 2010 Nov;343(11-12):612-24

Department of Pharmaceutical Chemistry, University of Oslo, Norway.

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http://dx.doi.org/10.1002/ardp.201000189DOI Listing
November 2010

1,2,3-triazole analogs of combretastatin A-4 as potential microtubule-binding agents.

Bioorg Med Chem 2010 Sep 17;18(18):6874-85. Epub 2010 Jul 17.

School of Pharmacy, Department of Pharmaceutical Chemistry, University of Oslo, PO Box 1068, N-0316 Oslo, Norway.

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http://dx.doi.org/10.1016/j.bmc.2010.07.032DOI Listing
September 2010

Identification of novel quinazolin-4(3H)-ones as inhibitors of thermolysin, the prototype of the M4 family of proteinases.

Bioorg Med Chem 2010 Jun 29;18(12):4317-27. Epub 2010 Apr 29.

Medical Pharmacology and Toxicology, Department of Medical Biology, Faculty of Health Science, University of Tromsø, N-9037 Tromsø, Norway.

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http://dx.doi.org/10.1016/j.bmc.2010.04.083DOI Listing
June 2010

The development and validation of a novel virtual screening cascade protocol to identify potential serotonin 5-HT(7)R antagonists.

Bioorg Med Chem Lett 2010 Apr 6;20(8):2465-8. Epub 2010 Mar 6.

Institute of Pharmacology, Polish Academy of Sciences, Smetna, Kraków, Poland.

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http://linkinghub.elsevier.com/retrieve/pii/S0960894X1000333
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http://dx.doi.org/10.1016/j.bmcl.2010.03.012DOI Listing
April 2010

Structure and localisation of drug binding sites on neurotransmitter transporters.

J Mol Model 2009 Oct 24;15(10):1155-64. Epub 2009 Feb 24.

Department of Pharmacology, Institute of Medical Biology, University of Tromsø, Norway.

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http://dx.doi.org/10.1007/s00894-009-0478-1DOI Listing
October 2009

Determinants for psychrophilic and thermophilic features of metallopeptidases of the M4 family.

In Silico Biol 2009 ;9(3):105-24

Department of Pharmacology, Institute of Medical Biology, Faculty of Medicine, University of Tromsø, Tromsø, Norway.

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October 2009

Binding site of ABC transporter homology models confirmed by ABCB1 crystal structure.

Theor Biol Med Model 2009 Sep 4;6:20. Epub 2009 Sep 4.

Department of Medical Pharmacology and Toxicology, Institute of Medical Biology, Faculty of Health Sciences, University of Tromsø, N-9037 Tromsø, Norway.

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http://dx.doi.org/10.1186/1742-4682-6-20DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2747915PMC
September 2009

Discovery of potent thermolysin inhibitors using structure based virtual screening and binding assays.

J Med Chem 2009 Jan;52(1):48-61

Department of Pharmacology, Institute of Medical Biology, Faculty of Medicine, University of Tromsø, N-9037, Tromsø, Norway.

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http://dx.doi.org/10.1021/jm8008019DOI Listing
January 2009

The thermolysin family (M4) of enzymes: therapeutic and biotechnological potential.

Chem Biol Drug Des 2009 Jan;73(1):7-16

Department of Pharmacology, Institute of Medical Biology, Faculty of Medicine, University of Tromsø, N-9037 Tromsø, Norway.

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http://dx.doi.org/10.1111/j.1747-0285.2008.00757.xDOI Listing
January 2009

A molecular model of a putative substrate releasing conformation of multidrug resistance protein 5 (MRP5).

Eur J Med Chem 2008 Nov 25;43(11):2557-67. Epub 2008 Jan 25.

Department of Pharmacology, Institute of Medical Biology, Faculty of Medicine, University of Tromsø, MH-Building, Breivika, N-9037 Tromsø, Norway.

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http://dx.doi.org/10.1016/j.ejmech.2008.01.015DOI Listing
November 2008

Receptor-binding and pharmacokinetic properties of dopaminergic agonists.

Curr Top Med Chem 2008 ;8(12):1049-67

Department of Medical Biochemistry, Institute of Medical Biology, Faculty of Medicine, University of Tromsø, Norway.

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October 2008

The molecular interactions of buspirone analogues with the serotonin transporter.

Bioorg Med Chem 2008 Oct 5;16(20):9283-94. Epub 2008 Sep 5.

National Medicines Institute, 30/34 Chełmska Street, 00-725 Warsaw, Poland.

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http://dx.doi.org/10.1016/j.bmc.2008.09.005DOI Listing
October 2008

Molecular recognition of docosahexaenoic acid by peroxisome proliferator-activated receptors and retinoid-X receptor alpha.

J Mol Graph Model 2008 Sep 29;27(2):217-24. Epub 2008 Apr 29.

Department of Pharmacology, Faculty of Medicine, Institute of Medical Biology, University of Tromsø, Tromsø, Norway.

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http://dx.doi.org/10.1016/j.jmgm.2008.04.008DOI Listing
September 2008

Ligand-induced stabilization and activation of peroxisome proliferator-activated receptor gamma.

Chem Biol Drug Des 2008 Jul 11;72(1):50-7. Epub 2008 Jun 11.

Department of Pharmacology, Institute of Medical Biology, Faculty of Medicine, University of Tromsø, 9037 Tromsø, Norway.

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http://dx.doi.org/10.1111/j.1747-0285.2008.00677.xDOI Listing
July 2008

Theoretical calculations of the catalytic triad in short-chain alcohol dehydrogenases/reductases.

Biophys J 2008 Feb 2;94(4):1412-27. Epub 2007 Nov 2.

Department of Pharmacology, Institute of Medical Biology, Faculty of Medicine, University of Tromsø, 9037 Tromsø, Norway.

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http://dx.doi.org/10.1529/biophysj.107.111096DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2212670PMC
February 2008

Predictive QSAR modeling for the successful predictions of the ADMET properties of candidate drug molecules.

Curr Drug Discov Technol 2007 Oct;4(3):141-9

School of Molecular and Structural Biology, and Department of Pharmacology, Institute of Medical Biology, Faculty of Medicine, University of Tromsø, 9037 Tromsø, Norway.

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October 2007

Molecular model of the outward facing state of the human P-glycoprotein (ABCB1), and comparison to a model of the human MRP5 (ABCC5).

Theor Biol Med Model 2007 Sep 6;4:33. Epub 2007 Sep 6.

Department of Pharmacology, Institute of Medical Biology, University of Tromsø, N-9037 Tromsø, Norway.

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http://dx.doi.org/10.1186/1742-4682-4-33DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2211457PMC
September 2007

A homology model of SERT based on the LeuT(Aa) template.

Bioorg Med Chem Lett 2006 Nov 17;16(21):5594-7. Epub 2006 Aug 17.

Department of Pharmacology, Institute of Medical Biology, University of Tromsø, N-9037 Tromsø, Norway.

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http://dx.doi.org/10.1016/j.bmcl.2006.08.028DOI Listing
November 2006

From genomics to drug targets.

J Psychopharmacol 2006 Jul;20(4 Suppl):95-9

Department of Pharmacology, Institute of Medical Biology, University of Tromsø, Tromsø, Norway.

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http://dx.doi.org/10.1177/1359786806066088DOI Listing
July 2006

Putative drug binding conformations of monoamine transporters.

Bioorg Med Chem 2006 Feb 10;14(3):666-75. Epub 2005 Oct 10.

Department of Pharmacology, Institute of Medical Biology, University of Tromsø, N-9037 Tromsø, Norway.

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http://dx.doi.org/10.1016/j.bmc.2005.08.054DOI Listing
February 2006

Comparative sequence and structure analysis reveal features of cold adaptation of an enzyme in the thermolysin family.

Proteins 2006 Feb;62(2):435-49

Department of Pharmacology, Institute of Medical Biology, Faculty of Medicine, University of Tromsø, Tromsø, Norway.

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http://dx.doi.org/10.1002/prot.20773DOI Listing
February 2006

Molecular insight into pseudolysin inhibition using the MM-PBSA and LIE methods.

J Struct Biol 2006 Feb 5;153(2):129-44. Epub 2005 Dec 5.

Department of Pharmacology, Institute of Medical Biology, Faculty of Medicine, University of Tromsø, N-9037 Tromsø, Norway.

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http://dx.doi.org/10.1016/j.jsb.2005.11.003DOI Listing
February 2006

Pancreatic trypsin activates human promatrix metalloproteinase-2.

J Mol Biol 2005 Jul;350(4):682-98

Department of Biochemistry, Institute of Medical Biology, University of Tromsø, N-9037 Tromsø, Norway.

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http://dx.doi.org/10.1016/j.jmb.2005.05.018DOI Listing
July 2005

The protein-protein interactions between SMPI and thermolysin studied by molecular dynamics and MM/PBSA calculations.

J Biomol Struct Dyn 2005 Apr;22(5):521-31

Department of Pharmacology, Institute of Medical Biology, Faculty of Medicine, University of Tromsø, N-9037 Tromsø, Norway.

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http://dx.doi.org/10.1080/07391102.2005.10507022DOI Listing
April 2005

Conformational restrictions in ligand binding to the human intestinal di-/tripeptide transporter: implications for design of hPEPT1 targeted prodrugs.

Bioorg Med Chem 2005 Mar;13(6):1977-88

Department of Medicinal Chemistry, Institute of Pharmacy, University of Tromsø, N-9037 Tromsø, Norway.

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http://dx.doi.org/10.1016/j.bmc.2005.01.019DOI Listing
March 2005

Molecular modelling of drug targets: the past, the present and the future.

Basic Clin Pharmacol Toxicol 2005 Mar;96(3):151-5

Department of Pharmacology, Institute of Medical Biology, University of Tromsø, N-9037 Tromsø, Norway.

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http://dx.doi.org/10.1111/j.1742-7843.2005.pto960302.xDOI Listing
March 2005

Atypical and typical antipsychotic drug interactions with the dopamine D2 receptor.

Eur J Med Chem 2005 Feb;40(2):185-94

Department of Pharmacology, Institute of Medical Biology, University of Tromsø, N-9037 Tromsø, Norway.

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http://dx.doi.org/10.1016/j.ejmech.2004.10.010DOI Listing
February 2005

Molecular model of the neural dopamine transporter.

J Comput Aided Mol Des 2003 May-Jun;17(5-6):367-82

Department of Pharmacology, Institute of Medical Biology, University of Tromsø, N-9037 Tromsø, Norway.

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July 2004

Structures and models of transporter proteins.

J Pharmacol Exp Ther 2004 Jun 26;309(3):853-60. Epub 2004 Feb 26.

Department of Pharmacology, Institute of Medical Biology, University of Tromsø, N-9037 Tromsø, Norway.

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http://dx.doi.org/10.1124/jpet.103.059972DOI Listing
June 2004

Molecular mechanism of citalopram and cocaine interactions with neurotransmitter transporters.

J Pharmacol Exp Ther 2003 Oct 27;307(1):34-41. Epub 2003 Aug 27.

Department of Pharmacology, Institute of Medical Biology, University of Tromsø, Norway.

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http://dx.doi.org/10.1124/jpet.103.054593DOI Listing
October 2003

Bioinformatics: from genome to drug targets.

Ann Med 2002 ;34(4):306-12

Department of Pharmacology, Institute of Medical Biology, Faculty of Medicine, University of Tromsø, Norway.

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February 2003

[New techniques for optimization of thiopurine therapy in leukemia and transplantation].

Tidsskr Nor Laegeforen 2002 Apr;122(11):1107-10

Avdeling for farmakologi Institutt for farmasi, Universitetet i Tromsø 9037 Troms.

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April 2002