Publications by authors named "Ingeborg Tinhofer"

41Publications

68Ga-PSMA-PET/CT-based radiosurgery and stereotactic body radiotherapy for oligometastatic prostate cancer.

PLoS One 2020 21;15(10):e0240892. Epub 2020 Oct 21.

Charité -Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Department of Radiation Oncology and Radiotherapy, Berlin, Germany.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0240892PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7577453PMC
October 2020

A FDG-PET radiomics signature detects esophageal squamous cell carcinoma patients who do not benefit from chemoradiation.

Sci Rep 2020 10 19;10(1):17671. Epub 2020 Oct 19.

Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Department of Radiation Oncology, Augustenburger Platz 1, 13353, Berlin, Germany.

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http://dx.doi.org/10.1038/s41598-020-74701-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7573602PMC
October 2020

A multilayered epithelial mucosa model of head neck squamous cell carcinoma for analysis of tumor-microenvironment interactions and drug development.

Biomaterials 2020 Nov 6;258:120277. Epub 2020 Aug 6.

Freie Universität Berlin, Institute of Pharmacy (Pharmacology & Toxicology), Königin-Luise-Str. 2+4, 14195, Berlin, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.biomaterials.2020.120277DOI Listing
November 2020

Preclinical models of head and neck squamous cell carcinoma for a basic understanding of cancer biology and its translation into efficient therapies.

Cancers Head Neck 2020 23;5. Epub 2020 Jul 23.

Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Department of Hematology and Oncology, Berlin, Germany.

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http://dx.doi.org/10.1186/s41199-020-00056-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7376675PMC
July 2020

Distinct immune evasion in APOBEC-enriched, HPV-negative HNSCC.

Int J Cancer 2020 Oct 18;147(8):2293-2302. Epub 2020 Jun 18.

Department of Hematology and Oncology, Campus Benjamin Franklin, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Hindenburgdamm 30, Berlin, 12203, Germany.

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http://dx.doi.org/10.1002/ijc.33123DOI Listing
October 2020

Radiosurgery and fractionated stereotactic body radiotherapy for patients with lung oligometastases.

BMC Cancer 2020 May 11;20(1):404. Epub 2020 May 11.

Department of Radiation Oncology and Radiotherapy, Charité - Universitätsmedizin Berlin, Augustenburger Platz 1, 13353, Berlin, Germany.

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http://dx.doi.org/10.1186/s12885-020-06892-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7216666PMC
May 2020

Comparison of GeneChip, nCounter, and Real-Time PCR-Based Gene Expressions Predicting Locoregional Tumor Control after Primary and Postoperative Radiochemotherapy in Head and Neck Squamous Cell Carcinoma.

J Mol Diagn 2020 06 2;22(6):801-810. Epub 2020 Apr 2.

German Cancer Consortium (DKTK) partner site Dresden, Dresden, Germany; German Cancer Research Center (DKFZ), Heidelberg; the OncoRay-National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Helmholtz-Zentrum Dresden-Rossendorf, Dresden, Germany; Department of Radiotherapy and Radiation Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany; National Center for Tumor Diseases (NCT), Partner Site Dresden, Germany: German Cancer Research Center (DKFZ), Heidelberg, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, and Helmholtz Association/Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Dresden, Germany.

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http://dx.doi.org/10.1016/j.jmoldx.2020.03.005DOI Listing
June 2020

Support of a molecular tumour board by an evidence-based decision management system for precision oncology.

Eur J Cancer 2020 03 23;127:41-51. Epub 2020 Jan 23.

Charité Comprehensive Cancer Center, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health, Charitéplatz 1, 10117, Berlin, Germany; Department of Hematology and Oncology, Campus Benjamin Franklin, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health, Hindenburgdamm 30, 12203 Berlin, Germany; Berlin Institute of Health (BIH), Anna-Louisa-Karsch-Straße 2, 10178, Berlin, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.ejca.2019.12.017DOI Listing
March 2020

Morphomolecular analysis of the immune tumor microenvironment in human head and neck cancer.

Cancer Immunol Immunother 2019 Sep 23;68(9):1443-1454. Epub 2019 Aug 23.

Institute of Pathology, Charité Hospital, Berlin, Germany.

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http://dx.doi.org/10.1007/s00262-019-02378-wDOI Listing
September 2019

Characterization of the tumor immune micromilieu and its interference with outcome after concurrent chemoradiation in patients with oropharyngeal carcinomas.

Oncoimmunology 2019 25;8(8):1614858. Epub 2019 May 25.

Department of Radiooncology and Radiotherapy, Berlin Institute of Health, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany.

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http://dx.doi.org/10.1080/2162402X.2019.1614858DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6682352PMC
May 2019

Novel prognostic clinical factors and biomarkers for outcome prediction in head and neck cancer: a systematic review.

Lancet Oncol 2019 06;20(6):e313-e326

Department of Radiation Oncology and Radiotherapy, Charité-Universitätsmedizin Berlin, Berlin, Germany; German Cancer Research Center, Heidelberg, Germany; German Cancer Consortium Partner Site Berlin, Berlin, Germany.

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http://dx.doi.org/10.1016/S1470-2045(19)30177-9DOI Listing
June 2019

A systematic review of the HPV-attributable fraction of oropharyngeal squamous cell carcinomas in Germany.

Cancer Med 2019 04 1;8(4):1908-1918. Epub 2019 Mar 1.

Department of Otorhinolaryngology, Head and Neck Surgery, Medical Faculty, University of Cologne, Cologne, Germany.

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http://dx.doi.org/10.1002/cam4.2039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6488137PMC
April 2019

Circulating tumor cells as biomarkers in head and neck cancer: recent advances and future outlook.

Expert Rev Mol Diagn 2018 10 21;18(10):897-906. Epub 2018 Sep 21.

a Department of Radiooncology and Radiotherapy , Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health , Berlin , Germany.

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https://www.tandfonline.com/doi/full/10.1080/14737159.2018.1
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http://dx.doi.org/10.1080/14737159.2018.1522251DOI Listing
October 2018

The role of Next-Generation Sequencing in tumoral radiosensitivity prediction.

Clin Transl Radiat Oncol 2017 Apr 9;3:16-20. Epub 2017 Apr 9.

Department of Radiooncology and Radiotherapy, Charité University Hospital Berlin, Berlin, Germany.

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http://dx.doi.org/10.1016/j.ctro.2017.03.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5893518PMC
April 2017

Multilayered Omics-Based Analysis of a Head and Neck Cancer Model of Cisplatin Resistance Reveals Intratumoral Heterogeneity and Treatment-Induced Clonal Selection.

Clin Cancer Res 2018 01 23;24(1):158-168. Epub 2017 Oct 23.

Charité, Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Department of Radiooncology and Radiotherapy, Berlin, Germany.

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http://clincancerres.aacrjournals.org/lookup/doi/10.1158/107
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http://dx.doi.org/10.1158/1078-0432.CCR-17-2410DOI Listing
January 2018

MiR-200b and miR-155 as predictive biomarkers for the efficacy of chemoradiation in locally advanced head and neck squamous cell carcinoma.

Eur J Cancer 2017 05 26;77:3-12. Epub 2017 Mar 26.

Translational Radiooncology Research Laboratory, Department of Radiooncology and Radiotherapy, Charité University Hospital, Berlin, Germany; German Cancer Research Center (DKFZ), Heidelberg, Germany; German Cancer Consortium (DKTK) Partner Site, Berlin, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.ejca.2017.02.018DOI Listing
May 2017

Spheroid Culture of Head and Neck Cancer Cells Reveals an Important Role of EGFR Signalling in Anchorage Independent Survival.

PLoS One 2016 19;11(9):e0163149. Epub 2016 Sep 19.

Translational Radiooncology and Radiobiology Research Laboratory, Department of Radiooncology and Radiotherapy, Charité University Hospital Berlin, Berlin, Germany.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0163149PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5028019PMC
August 2017

Mutational load and mutational patterns in relation to age in head and neck cancer.

Oncotarget 2016 Oct;7(43):69188-69199

Charité Comprehensive Cancer Center, Charité University Hospital, Charitéplatz, Berlin, Germany.

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http://dx.doi.org/10.18632/oncotarget.11312DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5342469PMC
October 2016

The rationale for including immune checkpoint inhibition into multimodal primary treatment concepts of head and neck cancer.

Cancers Head Neck 2016 10;1. Epub 2016 Aug 10.

4Comprehensive Cancer Center, Charité University Hospital, Berlin, Germany.

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http://dx.doi.org/10.1186/s41199-016-0009-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6460729PMC
August 2016

Patient and treatment-related risk factors for osteoradionecrosis of the jaw in patients with head and neck cancer.

Oral Surg Oral Med Oral Pathol Oral Radiol 2016 Mar 22;121(3):215-21.e1. Epub 2015 Oct 22.

Department of Radiation Oncology and Radiotherapy, Charité University Medicine, Berlin, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.oooo.2015.10.006DOI Listing
March 2016

Next-generation sequencing: hype and hope for development of personalized radiation therapy?

Radiat Oncol 2015 Aug 28;10:183. Epub 2015 Aug 28.

Department of Radiooncology and Radiotherapy, Charité University Hospital Berlin, Translational Radiation Oncology Research Laboratory, Charitéplatz 1, 10117, Berlin, Germany.

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http://dx.doi.org/10.1186/s13014-015-0481-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4554356PMC
August 2015

CCI-779 (Temsirolimus) exhibits increased anti-tumor activity in low EGFR expressing HNSCC cell lines and is effective in cells with acquired resistance to cisplatin or cetuximab.

J Transl Med 2015 Apr 1;13:106. Epub 2015 Apr 1.

Translational Radiooncology Laboratory, Department of Radiooncology and Radiotherapy, Charité University Hospital, Berlin, Germany.

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http://dx.doi.org/10.1186/s12967-015-0456-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4389307PMC
April 2015

Cancer stem cell characteristics of circulating tumor cells.

Int J Radiat Biol 2014 Aug 12;90(8):622-7. Epub 2014 May 12.

Translational Radiooncology and Radiobiology Research Laboratory, Department of Radiooncology and Radiotherapy.

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http://dx.doi.org/10.3109/09553002.2014.886798DOI Listing
August 2014

Monitoring of circulating tumor cells and their expression of EGFR/phospho-EGFR during combined radiotherapy regimens in locally advanced squamous cell carcinoma of the head and neck.

Int J Radiat Oncol Biol Phys 2012 Aug 12;83(5):e685-90. Epub 2012 May 12.

Translational Radiooncology Laboratory, Department of Radiooncology and Radiotherapy, Charité Campus Mitte, Charité Universitätsmedizin Berlin, Berlin, Germany.

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http://dx.doi.org/10.1016/j.ijrobp.2012.02.009DOI Listing
August 2012

A simple multicolor flow cytometry protocol for detection and molecular characterization of circulating tumor cells in epithelial cancers.

Cytometry A 2012 Jun 21;81(6):489-95. Epub 2012 Mar 21.

Translational Radiooncology Laboratory, Department of Radiotherapy, Charité Campus Mitte, Berlin, Germany.

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http://dx.doi.org/10.1002/cyto.a.22041DOI Listing
June 2012

Epithelial-mesenchymal-transition induced by EGFR activation interferes with cell migration and response to irradiation and cetuximab in head and neck cancer cells.

Radiother Oncol 2011 Oct 12;101(1):158-64. Epub 2011 Jun 12.

Laboratory for Translational Radiobiology & Radiooncology, Department of Radiooncology, Charité Campus Mitte, Berlin, Germany.

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http://dx.doi.org/10.1016/j.radonc.2011.05.042DOI Listing
October 2011

Expression of amphiregulin and EGFRvIII affect outcome of patients with squamous cell carcinoma of the head and neck receiving cetuximab-docetaxel treatment.

Clin Cancer Res 2011 Aug 8;17(15):5197-204. Epub 2011 Jun 8.

Department of Radiotherapy Campus Mitte, Translational Radiobiology and Radiooncology Research Laboratory, Charite Universit€atsmedizin Berlin, Chariteplatz 1, 10117Berlin, Germany.

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http://clincancerres.aacrjournals.org/cgi/doi/10.1158/1078-0
Publisher Site
http://dx.doi.org/10.1158/1078-0432.CCR-10-3338DOI Listing
August 2011

Prestaining of PCR products with SYBR Green for agarose gel electrophoresis: advantages and limitations.

Clin Chem Lab Med 2011 Jun 17;49(6):1069-71. Epub 2011 Mar 17.

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http://dx.doi.org/10.1515/CCLM.2011.171DOI Listing
June 2011

Eradication of EGFR-positive circulating tumor cells and objective tumor response with lapatinib and capecitabine.

Cancer Biol Ther 2010 Nov 1;10(9):860-4. Epub 2010 Nov 1.

Department of Hematology and Medical Oncology, Charité, Berlin, Germany.

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http://dx.doi.org/10.4161/cbt.10.9.13323DOI Listing
November 2010

Modifying akt signaling in B-cell chronic lymphocytic leukemia cells.

Cancer Res 2010 Sep 7;70(18):7336-44. Epub 2010 Sep 7.

Laboratory for Immunological and Molecular Cancer Research, University Clinics of Internal Medicine III with Hematology, Oncology, Hemostaseology, Infectiology and Rheumatology, Salzburg, Austria.

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http://dx.doi.org/10.1158/0008-5472.CAN-09-4411DOI Listing
September 2010

Pifithrin-α as a potential cytoprotective agent in radiotherapy: protection of normal tissue without decreasing therapeutic efficacy in glioma cells.

Radiat Res 2010 Nov 18;174(5):601-10. Epub 2010 Aug 18.

Translational Radiobiology & Radiooncology Research Laboratory, Department of Radiotherapy, Charité Universitätsmedizin-Berlin, Germany.

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http://dx.doi.org/10.1667/RR2147.1DOI Listing
November 2010

Association of epidermal growth factor receptor polymorphism, skin toxicity, and outcome in patients with squamous cell carcinoma of the head and neck receiving cetuximab-docetaxel treatment.

Clin Cancer Res 2010 Jan 22;16(1):304-10. Epub 2009 Dec 22.

Department of Hematology and Oncology, Campus Benjamin Franklin and Laboratory for Translational Radiobiology & Radiooncology, Charité-Universitätsmedizin Berlin, Berlin, Germany.

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http://dx.doi.org/10.1158/1078-0432.CCR-09-1928DOI Listing
January 2010

Regulation of calcium signalling by the small GTP-binding proteins Ras and Rac1.

Adv Enzyme Regul 2007 23;47:169-83. Epub 2006 Dec 23.

Innsbruck Biocenter, Division of Medical Biochemistry, Medical University of Innsbruck, Austria.

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http://dx.doi.org/10.1016/j.advenzreg.2006.12.017DOI Listing
November 2007