Inge Bernstein

Inge Bernstein

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Inge Bernstein

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Risk of post-colonoscopy colorectal cancer in Denmark: time trends and comparison with Sweden and the English National Health Service.

Endoscopy 2019 08 7;51(8):733-741. Epub 2019 Jun 7.

Department of Health Science and Technology, Aalborg University, Aalborg, Denmark.

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http://dx.doi.org/10.1055/a-0919-4803DOI Listing
August 2019

Cancer risks by gene, age, and gender in 6350 carriers of pathogenic mismatch repair variants: findings from the Prospective Lynch Syndrome Database.

Genet Med 2019 Jul 24. Epub 2019 Jul 24.

Department of Tumor Biology, Institute of Cancer Research, The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway.

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http://dx.doi.org/10.1038/s41436-019-0596-9DOI Listing
July 2019

Risk of multiple colorectal cancer development depends on age and subgroup in individuals with hereditary predisposition.

Fam Cancer 2019 04;18(2):183-191

The Danish HNPCC Register, Clinical Research Centre, Copenhagen University Hospital, Hvidovre, Kettegaard Allé 30, DK2650, Hvidovre, Denmark.

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http://dx.doi.org/10.1007/s10689-018-0109-zDOI Listing
April 2019

Lack of association between screening interval and cancer stage in Lynch syndrome may be accounted for by over-diagnosis; a prospective Lynch syndrome database report.

Hered Cancer Clin Pract 2019 28;17. Epub 2019 Feb 28.

4Department of Tumor Biology, Institute of Cancer Research, The Norwegian Radium Hospital, part of Oslo University Hospital, Olso, Norway.

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https://hccpjournal.biomedcentral.com/articles/10.1186/s1305
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http://dx.doi.org/10.1186/s13053-019-0106-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6394091PMC
February 2019

Cancer Risks for PMS2-Associated Lynch Syndrome.

J Clin Oncol 2018 10 30;36(29):2961-2968. Epub 2018 Aug 30.

Sanne W. ten Broeke, Heleen M. van der Klift, Carli M.J. Tops, Manon Suerink, Frederik J. Hes, Hans F.A. Vasen, Juul T. Wijnen, and Maartje Nielsen, Leiden University Medical Center, Leiden; Encarna Gomez Garcia, Maastricht University Medical Center, Maastricht; Nicoline Hoogerbrugge, Arjen R. Mensenkamp, and Liesbeth Spruijt, Radboud University Medical Center, Nijmegen; Tom G.W. Letteboer, University Medical Center, Utrecht; Theo A.M. van Os and Egbert J.W. Redeker, Academic Medical Center, Amsterdam; Maran J.W. Olderode-Berends and Yvonne J. Vos, University of Groningen; University Medical Center Groningen, Groningen; Anja Wagner, Erasmus Medical Center, Rotterdam, the Netherlands; Stefan Aretz, University of Bonn; University Hospital Bonn, Bonn; Christoph Engel, Leipzig University; Medizinisch Genetisches Zentrum Bayerstr, Leipzig; Magnus von Knebel Doeberitz, University of Heidelberg; German Cancer Research Center, Heidelberg; Pål Møller, University of Witten-Herdecke, Wuppertal; Nils Rahner, Heinrich-Heine-University, Düsseldorf; Hans K. Schackert, Technische Universität Dresden, Dresden; Verena Steinke-Lange, Medizinische Klinik und Poliklinik IV Campus Innenstadt, Klinikum der Universität München, Munich, Germany; Pål Møller, The Norwegian Radium Hospital; Oslo University Hospital, Oslo, Norway; Inge Bernstein, Hvidovre Hospital, Hvidovre, and Aalborg University Hospital, Aalborg, Denmark; Daniel D. Buchanan, Mark Clendenning, John L. Hopper, Mark A. Jenkins, Christophe Rosty, Ingrid Winship, and Aung Ko Win, The University of Melbourne; Daniel D. Buchanan, Ingrid Winship, and Aung Ko Win, Royal Melbourne Hospital, Parkville, Melbourne, Victoria; Rodney Scott, University of Newcastle, Newcastle, New South Wales, Australia; Albert de la Chapelle, Heather L. Hampel, Rachel Pearlman, and Leigha Senter, The Ohio State University Comprehensive Cancer Center, Columbus, OH; Gabriel Capella and Marta Pineda, Institut d'Investigació Biomédica de Bellvitge, Barcelona, Spain; Steven Gallinger, Mount Sinai Hospital, Toronto, Ontario, Canada; Jane C. Figueiredo and Robert Haile, Cedars-Sinai Medical Center, Los Angeles, CA; Loic Le Marchand, University of Hawaii Cancer Center, Honolulu, HI; Annika Lindblom, Karolinska Institutet; Karolinska University Hospital, Stockholm, Sweden; Noralane M. Lindor, Mayo Clinic Arizona, Scottsdale, AZ; Polly A. Newcomb, Fred Hutchinson Cancer Research Center; University of Washington, Seattle, WA; and Stephen Thibodeau, Mayo Clinic, Rochester, MN.

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http://ascopubs.org/doi/10.1200/JCO.2018.78.4777
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http://dx.doi.org/10.1200/JCO.2018.78.4777DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6349460PMC
October 2018

Outcome of 24 years national surveillance in different hereditary colorectal cancer subgroups leading to more individualised surveillance.

J Med Genet 2017 05 30;54(5):297-304. Epub 2016 Dec 30.

Danish HNPCC register, Clinical Research Centre, Copenhagen University Hospital, Hvidovre, Denmark.

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http://dx.doi.org/10.1136/jmedgenet-2016-104284DOI Listing
May 2017

Practical Approaches to the Development of Biomedical Informatics: the INFOBIOMED Network of Excellence.

Stud Health Technol Inform 2005 ;116:39-44

Coordination Centre for Clinical Trials, Heinrich-Heine-University, Düsseldorf, Germany.

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April 2016

Lynch syndrome caused by germline PMS2 mutations: delineating the cancer risk.

J Clin Oncol 2015 Feb 15;33(4):319-25. Epub 2014 Dec 15.

Sanne W. ten Broeke, Carli M. Tops, Heleen M. van der Klift, Manon Suerink, Frederik J. Hes, Hans F. Vasen, Maartje Nielsen, and Juul T. Wijnen, Leiden University Medical Center; Hans F. Vasen, The Netherlands Foundation for the Detection of Hereditary Tumors, Leiden; Richard M. Brohet, Research Center Linnaeus Institute, Spaarne Hospital, Hoofddorp; Mary E. Velthuizen and Tom G.W. Letteboer, University Medical Center Utrecht, Utrecht; Encarna Gomez Garcia, Maastricht University Medical Center, Maastricht; Nicoline Hoogerbrugge, Arjen R. Mensenkamp, and Liesbeth Spruijt, Radboud University Medical Center, Nijmegen; Fred H. Menko, Vrije Universiteit, University Medical Center; Theo A. van Os and Bert J.W. Redeker, Academic Medical Center, Amsterdam; Rolf H. Sijmons and Yvonne J. Vos, University of Groningen, University Medical Center Groningen, Groningen; Anja Wagner, Erasmus University Medical Center, Rotterdam, the Netherlands; Inge Bernstein, Aalborg University Hospital, Aalborg; Inge Bernstein, Danish Hereditary Nonpolyposis Colorectal Cancer Registry, Hvidovre University Hospital Copenhagen, Denmark; Gabriel Capellá Munar, Hereditary Cancer Program, Catalan Institute of Oncology-Institut D'Investigació Biomèdica de Bellvitge, l'Hospitalet de Llobregat, Spain; Annika Lindblom, Karolinska Institutet, Karolinska University Hospital, Solna; Pal Moller, Research Group Inherited Cancer, Oslo University Hospital, Oslo, Norway; and Nils Rahner, Institute of Human Genetics, University of Dusseldorf, Dusseldorf, Germany.

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http://dx.doi.org/10.1200/JCO.2014.57.8088DOI Listing
February 2015

Balancing life with an increased risk of cancer: lived experiences in healthy individuals with Lynch syndrome.

J Genet Couns 2014 Oct 8;23(5):778-84. Epub 2014 Jan 8.

The HNPCC Register, Clinical Research Centre, Hvidovre Hospital, Copenhagen University, Kettegaard Allé 30, 2650, Hvidovre, Denmark,

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http://dx.doi.org/10.1007/s10897-013-9682-3DOI Listing
October 2014

[Juvenile polyposis syndrome is a rare cause of gastrointestinal cancer].

Ugeskr Laeger 2014 Oct;176(44)

Klinisk Genetisk Afdeling, Odense Universitetshospital, Sdr. Boulevard 29, 5000 Odense C.

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October 2014

The results of gynecologic surveillance in families with hereditary nonpolyposis colorectal cancer.

Gynecol Oncol 2014 Jun 13;133(3):526-30. Epub 2014 Mar 13.

HNPCC-Register, Department of Gastroenterology and Clinical Research Centre, Copenhagen University Hospital, Hvidovre, Denmark; Department of Surgical Gastroenterology, Aalborg University Hospital, Denmark.

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http://dx.doi.org/10.1016/j.ygyno.2014.03.012DOI Listing
June 2014

A pooled analysis of the outcome of prospective colonoscopic surveillance for familial colorectal cancer.

Int J Cancer 2014 Feb 29;134(4):939-47. Epub 2013 Aug 29.

Queen Mary University of London, Centre for Cancer Prevention, Wolfson Institute of Preventive Medicine, Charterhouse Square, London, United Kingdom.

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http://dx.doi.org/10.1002/ijc.28397DOI Listing
February 2014

[Juvenile polyposis syndrome is a rare cause of gastrointestinal cancer].

Ugeskr Laeger 2013 Nov;175(47A)

Klinisk Genetisk Afdeling, Odense Universitetshospital, Sdr. Boulevard 29, 5000 Odense C.

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November 2013

Surveillance for urinary tract cancer in Lynch syndrome.

Fam Cancer 2013 Jun;12(2):279-84

The Danish HNPCC-register, Department of Gastroenterology and Clinical Research Center, Copenhagen University Hospital, Hvidovre, Denmark.

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http://link.springer.com/10.1007/s10689-013-9634-y
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http://dx.doi.org/10.1007/s10689-013-9634-yDOI Listing
June 2013

Gain of chromosomal region 20q and loss of 18 discriminates between Lynch syndrome and familial colorectal cancer.

Eur J Cancer 2013 Apr 11;49(6):1226-35. Epub 2012 Dec 11.

The Danish HNPCC Register, Clinical Research Centre and Department of Gastroenterology, Copenhagen University Hospital, Hvidovre, Denmark.

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https://linkinghub.elsevier.com/retrieve/pii/S09598049120089
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http://dx.doi.org/10.1016/j.ejca.2012.11.011DOI Listing
April 2013

Cancer risks and immunohistochemical profiles linked to the Danish MLH1 Lynch syndrome founder mutation.

Fam Cancer 2012 Dec;11(4):579-85

HNPCC Register, Clinical Research Centre, Copenhagen University Hospital, Kettegård Alle 30, Hvidovre, Denmark.

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http://link.springer.com/10.1007/s10689-012-9552-4
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http://dx.doi.org/10.1007/s10689-012-9552-4DOI Listing
December 2012

Awareness of endometrial cancer risk and compliance with screening in hereditary nonpolyposis colorectal cancer.

Obstet Gynecol 2012 Nov;120(5):1005-12

The Danish HNPCC-register, Department of Surgical Gastroenterology, Copenhagen University Hospital, Hvidovre, Denmark.

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http://dx.doi.org/10.1097/aog.0b013e31826ba2aaDOI Listing
November 2012

MSH6 mutations are frequent in hereditary nonpolyposis colorectal cancer families with normal pMSH6 expression as detected by immunohistochemistry.

Appl Immunohistochem Mol Morphol 2012 Oct;20(5):470-7

Department of Clinical Biochemistry, Section of Molecular Diagnostics, Aalborg University Hospital, Aalborg, Denmark.

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http://dx.doi.org/10.1097/PAI.0b013e318249739bDOI Listing
October 2012

Hereditary colorectal cancer diagnostics: morphological features of familial colorectal cancer type X versus Lynch syndrome.

J Clin Pathol 2012 Apr 28;65(4):352-6. Epub 2012 Jan 28.

Clinical Research Centre, Hvidovre Hospital, University of Copenhagen, Hvidovre, Denmark.

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http://dx.doi.org/10.1136/jclinpath-2011-200535DOI Listing
April 2012

Limited impact on self-concept in individuals with Lynch syndrome; results from a national cohort study.

Fam Cancer 2011 Dec;10(4):633-9

Clinical Research Centre, Hvidovre University Hospital, Copenhagen University, Copenhagen, Denmark.

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http://dx.doi.org/10.1007/s10689-011-9459-5DOI Listing
December 2011

Challenges in the identification of MSH6-associated colorectal cancer: rectal location, less typical histology, and a subset with retained mismatch repair function.

Am J Surg Pathol 2011 Sep;35(9):1391-9

Clinical Research Center, Department of Pathology, Hvidovre Hospital, University of Copenhagen, Hvidovre, Sweden.

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http://dx.doi.org/10.1097/PAS.0b013e318225c3f0DOI Listing
September 2011

Deranged Wnt signaling is frequent in hereditary nonpolyposis colorectal cancer.

Fam Cancer 2011 Jun;10(2):239-43

Department of Oncology, Institute of Clinical Sciences, Lund University, Lund, Sweden.

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http://dx.doi.org/10.1007/s10689-010-9406-xDOI Listing
June 2011

Validation of a self-concept scale for Lynch syndrome in different nationalities.

J Genet Couns 2011 Jun 26;20(3):308-13. Epub 2011 Jan 26.

Clinical Research Centre, Hvidovre University Hospital, Copenhagen University, Hvidovre, Denmark.

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http://dx.doi.org/10.1007/s10897-011-9349-xDOI Listing
June 2011

Ovarian cancer linked to Lynch syndrome typically presents as early-onset, non-serous epithelial tumors.

Gynecol Oncol 2011 Jun 9;121(3):462-5. Epub 2011 Mar 9.

HNPCC-register, Department of Gastroenterology, Faculty of Health Sciences, Hvidovre University Hospital, Copenhagen University, Kettegård allé, Hvidovre, Denmark.

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http://dx.doi.org/10.1016/j.ygyno.2011.02.010DOI Listing
June 2011

Interobserver variability in the evaluation of mismatch repair protein immunostaining.

Hum Pathol 2010 Oct 22;41(10):1387-96. Epub 2010 Jun 22.

Department of Pathology, Hvidovre Hospital, Copenhagen University, Hvidovre, Denmark.

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http://dx.doi.org/10.1016/j.humpath.2010.03.003DOI Listing
October 2010

Mismatch repair defective breast cancer in the hereditary nonpolyposis colorectal cancer syndrome.

Breast Cancer Res Treat 2010 Apr 3;120(3):777-82. Epub 2009 Jul 3.

Department of Clinical Genetics, Arhus University Hospital, Wilhelm Meyers Alle, University Park, Arhus, Denmark.

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http://link.springer.com/10.1007/s10549-009-0449-3
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http://dx.doi.org/10.1007/s10549-009-0449-3DOI Listing
April 2010

Sarcomas associated with hereditary nonpolyposis colorectal cancer: broad anatomical and morphological spectrum.

Fam Cancer 2009 8;8(3):209-13. Epub 2009 Jan 8.

Clinical Research Centre, Hvidovre Hospital, Copenhagen University, Kettegård allé 30, 2650 Hvidovre, Denmark.

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http://dx.doi.org/10.1007/s10689-008-9230-8DOI Listing
January 2010

An effect from anticipation also in hereditary nonpolyposis colorectal cancer families without identified mutations.

Cancer Epidemiol 2009 Oct 12;33(3-4):231-4. Epub 2009 Sep 12.

HNPCC-Register, Department of Gastroenterology, Hvidovre University Hospital, Copenhagen University, Denmark.

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http://dx.doi.org/10.1016/j.canep.2009.06.007DOI Listing
October 2009

[Does the mounting of gastrointestinal biopsies on millipore filter contribute to an improved section quality?].

Ugeskr Laeger 2009 Sep;171(37):2646-50

Patologiafdelingen, Hvidovre Hospital, DK-2650 Hvidovre.

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September 2009

Biopsies of colorectal clinical polyps--emergence of diagnostic information on deeper levels.

Pathol Res Pract 2009 13;205(4):231-40. Epub 2009 Feb 13.

Department of Pathology, Hvidovre Hospital, Faculty of Health Sciences, University of Copenhagen, Hvidovre, Denmark.

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http://dx.doi.org/10.1016/j.prp.2008.08.003DOI Listing
August 2009

A parametric model for analyzing anticipation in genetically predisposed families.

Stat Appl Genet Mol Biol 2009 2;8:Article26. Epub 2009 Jun 2.

Hvidovre Hospital, Denmark.

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https://www.degruyter.com/view/j/sagmb.2009.8.1/sagmb.2009.8
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http://dx.doi.org/10.2202/1544-6115.1424DOI Listing
August 2009

Major contribution from recurrent alterations and MSH6 mutations in the Danish Lynch syndrome population.

Fam Cancer 2009 20;8(1):75-83. Epub 2008 Jun 20.

Clinical Research Centre and HNPCC-Register, Copenhagen University, Hvidovre University Hospital, Kettegård Allé 30, Hvidovre, 2650, Denmark.

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http://dx.doi.org/10.1007/s10689-008-9199-3DOI Listing
April 2009

Planning the human variome project: the Spain report.

Authors:
Jim Kaput Richard G H Cotton Lauren Hardman Michael Watson Aida I Al Aqeel Jumana Y Al-Aama Fahd Al-Mulla Santos Alonso Stefan Aretz Arleen D Auerbach Bharati Bapat Inge T Bernstein Jong Bhak Stacey L Bleoo Helmut Blöcker Steven E Brenner John Burn Mariona Bustamante Rita Calzone Anne Cambon-Thomsen Michele Cargill Paola Carrera Lawrence Cavedon Yoon Shin Cho Yeun-Jun Chung Mireille Claustres Garry Cutting Raymond Dalgleish Johan T den Dunnen Carlos Díaz Steven Dobrowolski M Rosário N dos Santos Rosemary Ekong Simon B Flanagan Paul Flicek Yoichi Furukawa Maurizio Genuardi Ho Ghang Maria V Golubenko Marc S Greenblatt Ada Hamosh John M Hancock Ross Hardison Terence M Harrison Robert Hoffmann Rania Horaitis Heather J Howard Carol Isaacson Barash Neskuts Izagirre Jongsun Jung Toshio Kojima Sandrine Laradi Yeon-Su Lee Jong-Young Lee Vera L Gil-da-Silva-Lopes Finlay A Macrae Donna Maglott Makia J Marafie Steven G E Marsh Yoichi Matsubara Ludwine M Messiaen Gabriela Möslein Mihai G Netea Melissa L Norton Peter J Oefner William S Oetting James C O'Leary Ana Maria Oller de Ramirez Mark H Paalman Jillian Parboosingh George P Patrinos Giuditta Perozzi Ian R Phillips Sue Povey Suyash Prasad Ming Qi David J Quin Rajkumar S Ramesar C Sue Richards Judith Savige Dagmar G Scheible Rodney J Scott Daniela Seminara Elizabeth A Shephard Rolf H Sijmons Timothy D Smith María-Jesús Sobrido Toshihiro Tanaka Sean V Tavtigian Graham R Taylor Jon Teague Thoralf Töpel Mollie Ullman-Cullere Joji Utsunomiya Henk J van Kranen Mauno Vihinen Elizabeth Webb Thomas K Weber Meredith Yeager Young I Yeom Seon-Hee Yim Hyang-Sook Yoo

Hum Mutat 2009 Apr;30(4):496-510

Division of Personalised Nutrition and Medicine, FDA/National Center for Toxicological Research, Jefferson, Arkansas 72079, USA.

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http://compbio.berkeley.edu/people/brenner/pubs/kaput-2009-h
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http://doi.wiley.com/10.1002/humu.20972
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http://dx.doi.org/10.1002/humu.20972DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5879779PMC
April 2009

HNPCC-associated synchronous early-stage signet-ring cell carcinomas of colonic origin. A comparative morphological and immunohistochemical study of an intramucosal and a submucosal example.

Virchows Arch 2009 Jan 11;454(1):115-24. Epub 2008 Nov 11.

Department of Pathology, HNPCC-register, Hvidovre Hospital, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark.

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http://dx.doi.org/10.1007/s00428-008-0691-9DOI Listing
January 2009

Role for genetic anticipation in Lynch syndrome.

J Clin Oncol 2009 Jan 15;27(3):360-4. Epub 2008 Dec 15.

Copenhagen University, Clinical Research Centre, Hvidovre, Denmark.

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http://ascopubs.org/doi/10.1200/JCO.2008.16.1281
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http://dx.doi.org/10.1200/JCO.2008.16.1281DOI Listing
January 2009

Risk of gynecologic cancers in Danish hereditary non-polyposis colorectal cancer families.

Acta Obstet Gynecol Scand 2008 ;87(11):1129-35

The Danish HNPCC Register, Department of Gastroenterology 435, Hvidovre University Hospital, Hvidovre, Denmark.

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http://dx.doi.org/10.1080/00016340802443806DOI Listing
December 2008

Cost-effectiveness of surveillance programs for families at high and moderate risk of hereditary non-polyposis colorectal cancer.

Int J Technol Assess Health Care 2007 ;23(1):89-95

DSI Danish Institute for Health Services Research, Dampfaergevej 27-29, 2100 Copenhagen, Denmark.

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http://www.journals.cambridge.org/abstract_S0266462307051616
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http://dx.doi.org/10.1017/S0266462307051616DOI Listing
April 2007

[Serrated, hyperplastic and hyperplasia-like colorectal polyps].

Ugeskr Laeger 2006 Nov;168(46):4005-9

H:S Hvidovre Hospital, Patologiafdelingen og HNPCC-Registret, Gastroenheden, Hvidovre.

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November 2006

[Hyperplastic colorectal polyposis].

Ugeskr Laeger 2006 Nov;168(46):4009-11

Amager Hospital, Kirurgisk Afdeling.

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November 2006

[Familial colorectal cancer].

Ugeskr Laeger 2006 Jun;168(24):2369-73

Arhus Universitetshospital, Arhus Sygehus, Klinisk Genetisk Afdeling, Onkogenetisk Klinik, DK-8000 Arhus C.

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June 2006

[Hereditary colorectal cancer].

Ugeskr Laeger 2005 Oct;167(44):4159-63

H:S Hvidovre Hospital, Gastroenheden 435, HNPCC-registret og Polyposeregistret, Hvidovre.

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October 2005

Presymptomatic diagnosis using a deletion of a single codon in families with hereditary non-polyposis colorectal cancer.

Mutat Res 2005 Feb;570(1):89-96

Department of Clinical Genetics, Copenhagen University Hospital, H:S Rigshospitalet, Blegdamsvej 9, DK-2100 Copenhagen O, Denmark.

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http://dx.doi.org/10.1016/j.mrfmmm.2004.10.002DOI Listing
February 2005

[Prevention of colorectal cancer in families with hereditary nonpolyposis colorectal cancer].

Ugeskr Laeger 2003 Jan;165(3):221-5

HNPCC-registret, gastroenheden, kirurgisk afsnit 435, H:S Hvidovre Hospital, Kettegårds Allé, DK-2650 Hvidovre.

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January 2003