Publications by authors named "Imke Metz"

60Publications

Antibody signatures in patients with histopathologically defined multiple sclerosis patterns.

Acta Neuropathol 2020 03 16;139(3):547-564. Epub 2020 Jan 16.

Institute of Neuropathology, University Medical Center Göttingen, Robert-Koch-Strasse 40, 37075, Göttingen, Germany.

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http://dx.doi.org/10.1007/s00401-019-02120-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7035238PMC
March 2020

A case of CLIPPERS syndrome responsive to tocilizumab.

Neurol Neuroimmunol Neuroinflamm 2019 05 1;6(3):e545. Epub 2019 Feb 1.

Department of Neurology (T.R., J.S.B., K.H.S., G.D., D.B., R.B., F.L.), Department of Rheumatology (R.Z.), and Neuroimmunology, Institute of Clinical Chemistry (F.L.), Division of Neurological Pain Research and Therapy (R.B.), University Hospital of Schleswig-Holstein, Kiel, Germany; Department of Neurology (T.R.), University of Florida, Gainesville, FL; and Institute of Neuropathology (I.M., W.B.), University Hospital Göttingen, Germany.

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http://dx.doi.org/10.1212/NXI.0000000000000545DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6410928PMC
May 2019

Drug reaction with eosinophilia and systemic symptoms after daclizumab therapy in MS.

Neurol Neuroimmunol Neuroinflamm 2018 Sep 10;5(5):e479. Epub 2018 Jul 10.

Department of Neurology (F.S., M.K., L.H., A.M.), Charité-Universitätsmedizin Berlin; Institute of Neuropathology (I.M.), Universitätsmedizin Göttingen, Göttingen, Germany; Institute of Neuropathology (H.R.), Charité-Universitätsmedizin Berlin, Institute of Neuroradiology (E.S.), Charité-Universitätsmedizin Berlin; Department of Neurosurgery (S.W.), Charité-Universitätsmedizin Berlin; NeuroCure Clinical Research Center (A.M.), Charité-Universitätsmedizin Berlin; and Center for Stroke Research Berlin (F.S., A.M.), Charité-Universitätsmedizin Berlin, Germany.

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http://dx.doi.org/10.1212/NXI.0000000000000479DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6047475PMC
September 2018

Drug reaction with eosinophilia and systemic symptoms after daclizumab therapy.

Neurology 2018 07 22;91(4):e359-e363. Epub 2018 Jun 22.

From the Departments of Neurology (S.R., A.S., A.M.) and Neuroradiology (H.U.), University Medical Center Freiburg; Institute of Neuropathology (L.S., W.B., I.M.), University Medical Center Goettingen; Institute of Neuropathology, Medical Faculty (P.S., M.P.), and BIOSS Centre for Biological Signalling Studies (M.P.), University of Freiburg, Germany.

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http://dx.doi.org/10.1212/WNL.0000000000005854DOI Listing
July 2018

Defining distinct features of anti-MOG antibody associated central nervous system demyelination.

Ther Adv Neurol Disord 2018 29;11:1756286418762083. Epub 2018 Mar 29.

Institute of Neuropathology, University Medical Center, Göttingen, Germany.

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http://dx.doi.org/10.1177/1756286418762083DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5881972PMC
March 2018

Detailed Characterization of T Cell Receptor Repertoires in Multiple Sclerosis Brain Lesions.

Front Immunol 2018 19;9:509. Epub 2018 Mar 19.

Neuroimmunology and MS Research (nims), Department of Neurology, University Zurich, Zürich, Switzerland.

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http://dx.doi.org/10.3389/fimmu.2018.00509DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5867461PMC
April 2019

Rescue therapy with alemtuzumab in B cell/antibody-mediated multiple sclerosis.

Ther Adv Neurol Disord 2018 8;11:1756286418759895. Epub 2018 Mar 8.

Department of Neurology, University Hospital of Dresden, Fetscherstraße 74, 01307, Dresden, Germany.

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http://dx.doi.org/10.1177/1756286418759895DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5846919PMC
March 2018

CLIPPERS with longitudinally extensive transverse myelitis: Role of T versus B cells.

J Neurol Sci 2018 02 18;385:96-98. Epub 2017 Dec 18.

Department of Neurology, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Germany. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S0022510X173451
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http://dx.doi.org/10.1016/j.jns.2017.12.021DOI Listing
February 2018

Increased interleukin-27 cytokine expression in the central nervous system of multiple sclerosis patients.

J Neuroinflammation 2017 07 24;14(1):144. Epub 2017 Jul 24.

Department of Pathology and Immunology, Geneva University Hospital and University of Geneva, 1211, Geneva 4, Switzerland.

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http://dx.doi.org/10.1186/s12974-017-0919-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5525372PMC
July 2017

Association of primary central nervous system vasculitis with the presence of specific human leucocyte antigen gene variant.

Clin Neurol Neurosurg 2017 Sep 23;160:137-141. Epub 2017 Jun 23.

Department of Neurology, Alfried-Krupp-von Bohlen und Halbach Hospital, Alfried-Krupp-Straße 21, 45130 Essen, Germany.

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https://linkinghub.elsevier.com/retrieve/pii/S03038467173017
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http://dx.doi.org/10.1016/j.clineuro.2017.06.009DOI Listing
September 2017

ADEM-like presentation, anti-MOG antibodies, and MS pathology: TWO case reports.

Neurol Neuroimmunol Neuroinflamm 2017 May 14;4(3):e335. Epub 2017 Mar 14.

Department of Neurology (P.K., M.P., H.-J.H., M.M.), Institute of Neuropathology (C.M.), University Hospital Magdeburg; German Center for Neurodegenerative Diseases (DZNE) Magdeburg (P.K.), Germany; Institute of Neurology (M.B., G.G.K., R.H.), Department of Pediatric and Adolescent Medicine (M.B.), Department of Neurology (P.R.), Division of Neuroradiology and Musculoskeletal Radiology (C.M.), Department of Biomedical Imaging and Image-guided Therapy, and Department of Neuroimmunology (H.L.), Center for Brain Research, Medical University of Vienna, Austria; Department of Neuropathology (I.M., W.B.), University Medical Center Göttingen; Leibniz Institute for Neurobiology (H.-J.H.), Magdeburg; Department of Neurology (M.M.), MEDIAN NRZ Flechtingen, Germany; Clinical Department of Neurology (M.R.), Innsbruck Medical University, Austria; Neuroimmunology (K.-P.W., F.L.), Institute of Clinical Chemistry, University Hospital Schleswig-Holstein, Kiel/Lübeck; Department of Neurology (K.-P.W.), University Hospital Schleswig-Holstein, Lübeck; and Department of Neurology (F.L.), University Hospital Schleswig-Holstein, Kiel, Germany.

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http://dx.doi.org/10.1212/NXI.0000000000000335DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5350621PMC
May 2017

Mutations in SNORD118 cause the cerebral microangiopathy leukoencephalopathy with calcifications and cysts.

Nat Genet 2016 10 29;48(10):1185-92. Epub 2016 Aug 29.

Faculty of Biology, Medicine and Health, School of Biological Sciences, Division of Evolution and Genomic Sciences, University of Manchester, Manchester, UK.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5045717PMC
http://dx.doi.org/10.1038/ng.3661DOI Listing
October 2016

Disseminated necrotizing leukoencephalopathy eight months after alemtuzumab treatment for multiple sclerosis.

Acta Neuropathol Commun 2016 08 8;4(1):81. Epub 2016 Aug 8.

Department of Neuropathology, University Medical Center Göttingen, Georg-August-University, Robert-Koch-Str. 40, 37075, Göttingen, Germany.

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http://dx.doi.org/10.1186/s40478-016-0352-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4977646PMC
August 2016

Autoantibodies to MOG in a distinct subgroup of adult multiple sclerosis.

Neurol Neuroimmunol Neuroinflamm 2016 Oct 30;3(5):e257. Epub 2016 Jun 30.

Institute of Clinical Neuroimmunology (M.S., L.A.G., M.K., F.S.T., E.S., R.H., E.M., T.K.), Department of Radiology (B.E.-W.), and Laboratory for Immunogenetics (A.D.), Medical Campus Großhadern, Ludwig-Maximilians-Universität München; Department of Neurology (M.K.), Hertie Institut für klinische Hirnforschung, Universitätsklinikum Tübingen; Department of Neuropathology (I.M., W.B.), University Medical Center, Georg August University, Göttingen; Department of Paediatric Neurology and Developmental Medicine (A.B.), Dr. von Hauner Children's Hospital, Ludwig-Maximilians-Universität München; and Munich Cluster for Systems Neurology (SyNergy) (R.H.), Munich, Germany.

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http://dx.doi.org/10.1212/NXI.0000000000000257DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4949775PMC
October 2016

Mouse model for molybdenum cofactor deficiency type B recapitulates the phenotype observed in molybdenum cofactor deficient patients.

Hum Genet 2016 07 2;135(7):813-26. Epub 2016 May 2.

Institute of Human Genetics, University Medical Center Goettingen, Heinrich-Dueker-Weg 12, 37073, Goettingen, Germany.

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http://dx.doi.org/10.1007/s00439-016-1676-4DOI Listing
July 2016

Immunological and pathological characterization of fatal rebound MS activity following natalizumab withdrawal.

Mult Scler 2017 01 11;23(1):72-81. Epub 2016 Jul 11.

Neuroimmunology Research Laboratory, Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montréal, QC, Canada/Multiple Sclerosis Clinic, Division of Neurology, CHUM-Notre-Dame Hospital, Montréal, QC, Canada/Department of Neurosciences, Faculty of Medicine, Université de Montréal, Montréal, QC, Canada.

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http://dx.doi.org/10.1177/1352458516641775DOI Listing
January 2017

Serum peptide reactivities may distinguish neuromyelitis optica subgroups and multiple sclerosis.

Neurol Neuroimmunol Neuroinflamm 2016 Apr 2;3(2):e204. Epub 2016 Feb 2.

Departments of Neuropathology (I.M., L.S., W.B.), Medical Statistics (T.B., D.E., T.F.), and Nephrology and Rheumatology, Internal Medicine (H.D.), University Medical Center Göttingen; Department of Neurology (F. Pache, K.R., F. Paul) and Clinical and Experimental Multiple Sclerosis Research Center (F. Pache, K.R., F. Paul), Charité-Universitätsmedizin Berlin; NeuroCure Clinical Research Center and Experimental and Clinical Research Center (F. Pache, F. Paul), Max Delbrueck Center for Molecular Medicine; Department of Neurology (M.R., O.A.), Medical Faculty, Heinrich-Heine-University Düsseldorf; and Molecular Neuroimmunology Group, Department of Neurology (S.J., B.W.), University of Heidelberg, Germany.

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http://dx.doi.org/10.1212/NXI.0000000000000204DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4747481PMC
April 2016

Screening for MOG-IgG and 27 other anti-glial and anti-neuronal autoantibodies in 'pattern II multiple sclerosis' and brain biopsy findings in a MOG-IgG-positive case.

Mult Scler 2016 10 11;22(12):1541-1549. Epub 2016 Feb 11.

Molecular Neuroimmunology Group, Department of Neurology, University of Heidelberg, Heidelberg, Germany.

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http://dx.doi.org/10.1177/1352458515622986DOI Listing
October 2016

Central role of Th2/Tc2 lymphocytes in pattern II multiple sclerosis lesions.

Ann Clin Transl Neurol 2015 Sep 8;2(9):875-93. Epub 2015 Jun 8.

Neuroimmunology and MS Research (nims), Department of Neurology, University Zurich Frauenklinikstrasse 26, 8091, Zürich, Switzerland.

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http://dx.doi.org/10.1002/acn3.218DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4574806PMC
September 2015

Cell type-specific Nrf2 expression in multiple sclerosis lesions.

Acta Neuropathol 2015 Aug 19;130(2):263-77. Epub 2015 Jun 19.

Department of Neuroimmunology, Center for Brain Research, Medical University of Vienna, Spitalgasse 4, 1090, Vienna, Austria.

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http://dx.doi.org/10.1007/s00401-015-1452-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4503875PMC
August 2015

Glial cells express nuclear nrf2 after fumarate treatment for multiple sclerosis and psoriasis.

Neurol Neuroimmunol Neuroinflamm 2015 Jun 2;2(3):e99. Epub 2015 Apr 2.

Department of Neuropathology (I.M., S.T., M.S.W., W.B.), University Medical Center, Georg August University, Göttingen, Germany; Department of Neurology (K.S.-K., R.G.), St. Josef-Hospital/Ruhr-University Bochum, Bochum, Germany; Institute of Neuropathology (K.K.), University of Duisburg-Essen, Essen, Germany; Institute of Clinical Neuropathology (M.B.), Klinikum Bremen Mitte, Bremen, Germany; Department of Neuropathology (K.N.), Rheinisch-Westfälische Technische Hochschule Aachen, Aachen, Germany; and Department of Neurology (T.B.), Universitätsklinikum Schleswig-Holstein, Kiel, Germany.

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http://dx.doi.org/10.1212/NXI.0000000000000099DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4386793PMC
June 2015

Progressive multifocal leukoencephalopathy during fumarate monotherapy of psoriasis.

Neurol Neuroimmunol Neuroinflamm 2015 Jun 12;2(3):e85. Epub 2015 Mar 12.

Departments of Neurology (R.H., S.F., A.K., R.S., R.G., A.C.), Dermatology (P.A.), and Radiology (B.B., C.L.), St. Josef Hospital Bochum, Ruhr University, Germany; and Department of Neuropathology (I.M.), University Medical Center, Georg August University, Göttingen, Germany.

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http://dx.doi.org/10.1212/NXI.0000000000000085DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4360799PMC
June 2015

Natalizumab analogon therapy is effective in a B cell-dependent multiple sclerosis model.

Neuropathol Appl Neurobiol 2015 Oct 2;41(6):814-31. Epub 2015 May 2.

Department of Neuropathology, University Medical Center, Georg August University, Göttingen, Germany.

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http://dx.doi.org/10.1111/nan.12220DOI Listing
October 2015

Extensive acute axonal damage in pediatric multiple sclerosis lesions.

Ann Neurol 2015 Apr 26;77(4):655-67. Epub 2015 Feb 26.

Department of Neuropathology, University Medical Center, Georg August University, Göttingen, Germany.

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http://dx.doi.org/10.1002/ana.24364DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4523885PMC
April 2015

High CCR5 expression in natalizumab-associated progressive multifocal leukoencephalopathy immune reconstitution inflammatory syndrome supports treatment with the CCR5 inhibitor maraviroc.

Acta Neuropathol 2015 Mar 22;129(3):467-8. Epub 2015 Jan 22.

Department of Neuropathology, University Medical Center Göttingen, Robert-Koch-Str. 40, 37075, Göttingen, Germany.

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http://dx.doi.org/10.1007/s00401-015-1391-6DOI Listing
March 2015

Diagnostic utility of aquaporin-4 in the analysis of active demyelinating lesions.

Neurology 2015 Jan 10;84(2):148-58. Epub 2014 Dec 10.

From the Department of Anatomy and Cell Biology and Cameco MS Neuroscience Research Center (B.F.G.P.), University of Saskatchewan, Saskatoon, Canada; the Departments of Neurology (Y.G., J.E.P., V.A.L., S.J.P., B.G.W., S.L.C., C.F.L.), Laboratory Medicine and Pathology (M.E.J., J.E.P., V.A.L., S.J.P., G.G.), and Immunology (V.A.L.), Mayo Clinic, Rochester, MN; the Department of Neurology (D.M.W., J.C.), Mayo Clinic, Scottsdale, AZ; the Department of Neuropathology (I.M., W.B.), University Medical Center, Georg August University, Göttingen, Germany; the Department of Neurology (E.A.S.), Mayo Clinic, Jacksonville, FL; the Department of Neurology (C.D.B.), Columbia University Medical Center, New York, NY; and the Department of Neurology (B.A.C.), Feinberg School of Medicine, Northwestern University, Evanston, IL.

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http://dx.doi.org/10.1212/WNL.0000000000001126DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4336081PMC
January 2015

Accumulation and therapeutic modulation of 6-sulfo LacNAc(+) dendritic cells in multiple sclerosis.

Neurol Neuroimmunol Neuroinflamm 2014 Oct 18;1(3):e33. Epub 2014 Sep 18.

Departments of Neurology (K.T., T.S., H.R., T.Z.) and Dermatology (C.G.), University Hospital, Dresden; Institute of Immunology (K.D., R.W., M.S.), Medical Faculty, TU Dresden; Department of Neuropathology (I.M., W.B.), University Medical Centre, Göttingen; Department of Neurology (H.T.), University Hospital, Ulm; Department of Dermatology (K.S.), University Hospital, Heidelberg; and Center for Regenerative Therapies Dresden (M.S.), Dresden, Germany.

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http://dx.doi.org/10.1212/NXI.0000000000000033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4204231PMC
October 2014

Pathologic heterogeneity persists in early active multiple sclerosis lesions.

Ann Neurol 2014 May 13;75(5):728-38. Epub 2014 May 13.

Department of Neuropathology, University Medical Center, Georg August University, Göttingen, Germany.

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http://dx.doi.org/10.1002/ana.24163DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4070313PMC
May 2014

Early loss of oligodendrocytes in human and experimental neuromyelitis optica lesions.

Acta Neuropathol 2014 Apr 30;127(4):523-38. Epub 2013 Nov 30.

Institute of Neuropathology, University Medical Centre Göttingen, Robert-Koch-Str. 40, 37099, Göttingen, Germany.

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http://dx.doi.org/10.1007/s00401-013-1220-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4229038PMC
April 2014

Limited TCF7L2 expression in MS lesions.

PLoS One 2013 20;8(8):e72822. Epub 2013 Aug 20.

Institute of Neuropathology, University Hospital Münster, Münster, Germany.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0072822PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3748032PMC
January 2015

Oligodendroglial lineage cells express nuclear p57kip2 in multiple sclerosis lesions.

Glia 2013 Aug 5;61(8):1250-60. Epub 2013 Jul 5.

Department of Neuropathology, University Medical Center Göttingen, Robert-Koch-Straße 40, Göttingen, Germany.

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http://dx.doi.org/10.1002/glia.22512DOI Listing
August 2013

Microglial nodules in early multiple sclerosis white matter are associated with degenerating axons.

Acta Neuropathol 2013 Apr 26;125(4):595-608. Epub 2013 Jan 26.

Department of Neuropathology, University Medical Center, Georg-August University Göttingen, Robert-Koch-Str. 40, 37075 Göttingen, Germany.

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http://dx.doi.org/10.1007/s00401-013-1082-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3611040PMC
April 2013

Neuromyelitis optica lesions may inform multiple sclerosis heterogeneity debate.

Ann Neurol 2012 Sep;72(3):385-94

Department of Neuropathology, University Medical Center, Georg August University, Göttingen, Germany.

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http://dx.doi.org/10.1002/ana.23621DOI Listing
September 2012

Immunological and clinical consequences of treating a patient with natalizumab.

Mult Scler 2012 Mar 9;18(3):335-44. Epub 2011 Sep 9.

Department of Neurology-Inflammatory Disorders of the Nervous System and Neurooncology, University of Münster, Münster, Germany.

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http://dx.doi.org/10.1177/1352458511421919DOI Listing
March 2012

Microsurgical fenestration of perineural cysts to the thecal sac at the level of the distal dural sleeve.

Acta Neurochir (Wien) 2011 Jul 12;153(7):1427-34; discussion 1434. Epub 2011 May 12.

Department of Neurosurgery, Center of Neurological Medicine, University of Göttingen, Göttingen, Germany.

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http://link.springer.com/10.1007/s00701-011-1043-0
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http://dx.doi.org/10.1007/s00701-011-1043-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3111602PMC
July 2011

Necrotizing infundibulo-hypophysitis: an entity too rare to be true?

Pituitary 2012 Jun;15(2):202-8

Department of Neurosurgery, University Medical Center, Georg August University, 37099, Göttingen, Germany.

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http://dx.doi.org/10.1007/s11102-011-0307-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3358537PMC
June 2012

Wallerian degeneration: a major component of early axonal pathology in multiple sclerosis.

Brain Pathol 2010 Sep 14;20(5):976-85. Epub 2010 Apr 14.

Department of Neuropathology, University Medical Center, Georg August University, Göttingen, Germany.

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http://dx.doi.org/10.1111/j.1750-3639.2010.00401.xDOI Listing
September 2010

Specific central nervous system recruitment of HLA-G(+) regulatory T cells in multiple sclerosis.

Ann Neurol 2009 Aug;66(2):171-83

Department of Neurology, University of Würzburg, Würzburg, Germany.

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http://dx.doi.org/10.1002/ana.21705DOI Listing
August 2009