Publications by authors named "Imane El Dika"

28Publications

Discordant DNA mismatch repair protein status between synchronous or metachronous gastrointestinal carcinomas: frequency, patterns, and molecular etiologies.

Authors:
Monika Vyas Canan Firat Jaclyn F Hechtman Martin R Weiser Rona Yaeger Chad Vanderbilt Jamal K Benhamida Ajaratu Keshinro Liying Zhang Peter Ntiamoah Marco Gonzalez Rebecca Andrade Imane El Dika Arnold J Markowitz J Joshua Smith Julio Garcia-Aguilar Efsevia Vakiani David S Klimstra Zsofia K Stadler Jinru Shia

Fam Cancer 2020 Oct 9. Epub 2020 Oct 9.

Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

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October 2020

Phase II trial of sorafenib and doxorubicin in patients with advanced hepatocellular carcinoma after disease progression on sorafenib.

Authors:
Imane El Dika Marinela Capanu Joanne F Chou James J Harding Michele Ly Anna D Hrabovsky Richard K G Do Jinru Shia Brittanie Millang Jennifer Ma Eileen M O'Reilly Ghassan K Abou-Alfa

Cancer Med 2020 Oct 25;9(20):7453-7459. Epub 2020 Aug 25.

Memorial Sloan Kettering Cancer Center, New York, NY, USA.

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October 2020

Molecular profiling and analysis of genetic aberrations aimed at identifying potential therapeutic targets in fibrolamellar carcinoma of the liver.

Authors:
Imane El Dika Anita S Bowman Michael F Berger Marinela Capanu Joanne F Chou Ryma Benayed Ahmet Zehir Jinru Shia Eileen M O'Reilly David S Klimstra David B Solit Ghassan K Abou-Alfa

Cancer 2020 Sep 14;126(18):4126-4135. Epub 2020 Jul 14.

Memorial Sloan Kettering Cancer Center, New York, New York, USA.

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September 2020

Phase Ib Study of Enzalutamide with or Without Sorafenib in Patients with Advanced Hepatocellular Carcinoma.

Authors:
James J Harding Robin K Kelley Benjamin Tan Marinela Capanu Gian Kinh Do Jinru Shia Joanne F Chou Christine S Ferrer Chayma Boussayoud Kerri Muenkel Hooman Yarmohammadi Imane El Dika Danny N Khalil Carmen Ruiz Mariam Rodriguez-Lee Peter Kuhn John Wilton Renuka Iyer Ghassan K Abou-Alfa

Oncologist 2020 Dec 2;25(12):e1825-e1836. Epub 2020 Jul 2.

Department of Medicine, Memorial Sloan Kettering Cancer Center, Weill Cornell Medical College, New York, New York, USA.

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December 2020

Hepatocellular carcinoma, novel therapies on the horizon.

Authors:
Imane El Dika Iman Makki Ghassan K Abou-Alfa

Chin Clin Oncol 2020 Jun 9. Epub 2020 Jun 9.

Memorial Sloan Kettering Cancer Center, New York, NY, USA; Weill Medical College at Cornell University, New York, NY, USA.

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June 2020

Genomic Methods Identify Homologous Recombination Deficiency in Pancreas Adenocarcinoma and Optimize Treatment Selection.

Authors:
Wungki Park Jiapeng Chen Joanne F Chou Anna M Varghese Kenneth H Yu Winston Wong Marinela Capanu Vinod Balachandran Caitlin A McIntyre Imane El Dika Danny N Khalil James J Harding Nima Ghalehsari Zoe McKinnell Sree B Chalasani Vladimir Makarov Pier Selenica Xin Pei Nicolas Lecomte David P Kelsen Ghassan K Abou-Alfa Mark E Robson Liying Zhang Michael F Berger Nikolaus Schultz Timothy A Chan Simon N Powell Jorge S Reis-Filho Christine A Iacobuzio-Donahue Nadeem Riaz Eileen M O'Reilly

Clin Cancer Res 2020 07 22;26(13):3239-3247. Epub 2020 May 22.

Memorial Sloan Kettering Cancer Center, New York, New York.

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July 2020

A Multicenter Randomized Three-Arm Phase II Study of (1) Everolimus, (2) Estrogen Deprivation Therapy (EDT) with Leuprolide + Letrozole, and (3) Everolimus + EDT in Patients with Unresectable Fibrolamellar Carcinoma.

Authors:
Imane El Dika Robert J Mayer Alan P Venook Marinela Capanu Michael P LaQuaglia Rachel Kobos Allison F O'Neill Joanne F Chou Michele Ly Celina Ang Eileen M O'Reilly John D Gordan Ghassan K Abou-Alfa

Oncologist 2020 Nov 26;25(11):925-e1603. Epub 2020 May 26.

Memorial Sloan Kettering Cancer Center, New York, New York, USA.

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November 2020

Germline alterations in patients with biliary tract cancers: A spectrum of significant and previously underappreciated findings.

Authors:
Hannah Maynard Zsofia K Stadler Michael F Berger David B Solit Michele Ly Maeve A Lowery Diana Mandelker Liying Zhang Emmett Jordan Imane El Dika Yelena Kemel Marc Ladanyi Mark E Robson Eileen M O'Reilly Ghassan K Abou-Alfa

Cancer 2020 01 3;126(9):1995-2002. Epub 2020 Feb 3.

Memorial Sloan Kettering Cancer Center, New York, New York.

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January 2020

Assessment of Treatment With Sorafenib Plus Doxorubicin vs Sorafenib Alone in Patients With Advanced Hepatocellular Carcinoma: Phase 3 CALGB 80802 Randomized Clinical Trial.

Authors:
Ghassan K Abou-Alfa Qian Shi Jennifer J Knox Andreas Kaubisch Donna Niedzwiecki James Posey Benjamin R Tan Petr Kavan Rakesh Goel Philip E Lammers Tanios S Bekaii-Saab Vincent C Tam Lakshmi Rajdev Robin K Kelley Imane El Dika Tyler Zemla Ryan I Potaracke Jennifer Balletti Anthony B El-Khoueiry James H Harding Jennifer M Suga Lawrence H Schwartz Richard M Goldberg Monica M Bertagnolli Jeffrey Meyerhardt Eileen M O'Reilly Alan P Venook

JAMA Oncol 2019 Sep 5. Epub 2019 Sep 5.

Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco.

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September 2019

Immune checkpoint inhibitors for hepatocellular carcinoma.

Authors:
Imane El Dika Danny N Khalil Ghassan K Abou-Alfa

Cancer 2019 Oct 10;125(19):3312-3319. Epub 2019 Jul 10.

Gastrointestinal Oncology Service, Memorial Sloan Kettering Cancer Center, New York, New York.

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October 2019

Maximizing response: a case report of salvage chemotherapy after immune checkpoint inhibition in a patient with previous chemo-refractory metastatic esophageal carcinoma.

Authors:
Megan Greally Rajiv Agarwal Imane El Dika Ali Shamseddine Ashwaq El-Olayan Yolla Haibe Viktoriya Paroder Jinru Shia Ghassan K Abou-Alfa Geoffrey Y Ku

J Gastrointest Oncol 2019 Apr;10(2):367-372

Memorial Sloan Kettering Cancer Center, New York, NY, USA.

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April 2019

An Open-Label, Multicenter, Phase I, Dose Escalation Study with Phase II Expansion Cohort to Determine the Safety, Pharmacokinetics, and Preliminary Antitumor Activity of Intravenous TKM-080301 in Subjects with Advanced Hepatocellular Carcinoma.

Authors:
Imane El Dika Ho Yeong Lim Wei Peng Yong Chia-Chi Lin Jung-Hwan Yoon Manuel Modiano Bradley Freilich Hye Jin Choi Tsu-Yi Chao Robin K Kelley Joanne Brown Jennifer Knox Baek-Yeol Ryoo Thomas Yau Ghassan K Abou-Alfa

Oncologist 2019 06 31;24(6):747-e218. Epub 2018 Dec 31.

Memorial Sloan Kettering Cancer Center, New York New York, USA

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June 2019

Binimetinib plus Gemcitabine and Cisplatin Phase I/II Trial in Patients with Advanced Biliary Cancers.

Authors:
Maeve A Lowery Mikaela Bradley Joanne F Chou Marinela Capanu Scott Gerst James J Harding Imane El Dika Michael Berger Ahmet Zehir Ryan Ptashkin Philip Wong Teresa Rasalan-Ho Kenneth H Yu Andrea Cercek Ezra Morgono Erica Salehi Emily Valentino Ellen Hollywood Eileen M O'Reilly Ghassan K Abou-Alfa

Clin Cancer Res 2019 02 18;25(3):937-945. Epub 2018 Dec 18.

Memorial Sloan Kettering Cancer Center, New York, New York.

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February 2019

Prospective Genotyping of Hepatocellular Carcinoma: Clinical Implications of Next-Generation Sequencing for Matching Patients to Targeted and Immune Therapies.

Authors:
James J Harding Subhiksha Nandakumar Joshua Armenia Danny N Khalil Melanie Albano Michele Ly Jinru Shia Jaclyn F Hechtman Ritika Kundra Imane El Dika Richard K Do Yichao Sun T Peter Kingham Michael I D'Angelica Michael F Berger David M Hyman William Jarnagin David S Klimstra Yelena Y Janjigian David B Solit Nikolaus Schultz Ghassan K Abou-Alfa

Clin Cancer Res 2019 Apr 29;25(7):2116-2126. Epub 2018 Oct 29.

Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.

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April 2019

A Phase Ib, Open-Label Study of Dalantercept, an Activin Receptor-Like Kinase 1 Ligand Trap, plus Sorafenib in Advanced Hepatocellular Carcinoma.

Authors:
Ghassan K Abou-Alfa Rebecca A Miksad Mohamedtaki A Tejani Stephen Williamson Martin E Gutierrez Olugbenga O Olowokure Manish R Sharma Imane El Dika Matthew L Sherman Shuchi S Pandya

Oncologist 2019 02 23;24(2):161-e70. Epub 2018 Oct 23.

Acceleron Pharma, Cambridge, Massachusetts, USA.

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February 2019

Biomarker-Driven and Molecular Targeted Therapies for Hepatobiliary Cancers.

Authors:
William P Harris Kit Man Wong Supriya Saha Imane El Dika Ghassan K Abou-Alfa

Semin Oncol 2018 06 16;45(3):116-123. Epub 2018 Mar 16.

Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY; Weill Medical College at Cornell University, New York, NY. Electronic address:

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June 2018

Current and future therapies for targeting HER2 mutations in gastrointestinal cancer.

Authors:
Imane El Dika David H Ilson

Expert Rev Anticancer Ther 2018 11 21;18(11):1085-1092. Epub 2018 Aug 21.

a Department of Medicine , Memorial Sloan Kettering Cancer Center , New York , NY , USA.

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November 2018

A phase 1 study of ADI-PEG 20 and modified FOLFOX6 in patients with advanced hepatocellular carcinoma and other gastrointestinal malignancies.

Authors:
James J Harding Richard K Do Imane El Dika Ellen Hollywood Khrystyna Uhlitskykh Emily Valentino Peter Wan Casey Hamilton Xiaoxing Feng Amanda Johnston John Bomalaski Chien-Feng Li Eileen M O'Reilly Ghassan K Abou-Alfa

Cancer Chemother Pharmacol 2018 09 3;82(3):429-440. Epub 2018 Jul 3.

Memorial Sloan Kettering Cancer Center, New York, NY, USA.

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September 2018

Comprehensive Molecular Profiling of Intrahepatic and Extrahepatic Cholangiocarcinomas: Potential Targets for Intervention.

Authors:
Maeve A Lowery Ryan Ptashkin Emmet Jordan Michael F Berger Ahmet Zehir Marinela Capanu Nancy E Kemeny Eileen M O'Reilly Imane El-Dika William R Jarnagin James J Harding Michael I D'Angelica Andrea Cercek Jaclyn F Hechtman David B Solit Nikolaus Schultz David M Hyman David S Klimstra Leonard B Saltz Ghassan K Abou-Alfa

Clin Cancer Res 2018 09 30;24(17):4154-4161. Epub 2018 May 30.

Memorial Sloan Kettering Cancer Center, New York, New York.

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September 2018

Treatment options after sorafenib failure in patients with hepatocellular carcinoma.

Authors:
Imane El Dika Ghassan K Abou-Alfa

Clin Mol Hepatol 2017 12 20;23(4):273-279. Epub 2017 Nov 20.

Memorial Sloan Kettering Cancer Center, New York, NY, USA.

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December 2017

An elderly man with remote history of metastatic melanoma now with localized pancreas cancer and new liver masses.

Authors:
Neil Vasan Maria Ignez Braghiroli Alexander N Shoushtari Richard Kinh Gian Do Marcia Edelweiss Ali Shamseddine Walid Faraj Deborah Mukherji Ali Haydar Ashwaq Olayan Fouad Sabatin Rita Assi Imane El Dika Leonard B Saltz Ghassan K Abou-Alfa Eileen M O'Reilly

J Gastrointest Oncol 2017 Jun;8(3):596-602

Memorial Sloan Kettering Cancer Center, New York, NY, USA.

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June 2017

The role (if any) of chemotherapy in hepatocellular carcinoma.

Authors:
Imane El Dika Ghassan K Abou-Alfa

Lancet Gastroenterol Hepatol 2017 06 6;2(6):387-389. Epub 2017 Apr 6.

Department of Medicine, Weill Cornell Medical Colleage, New York, NT, USA. Electronic address:

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June 2017

Hyper-CVAD Compared With BFM-like Chemotherapy for the Treatment of Adult Acute Lymphoblastic Leukemia. A Retrospective Single-Center Analysis.

Authors:
Jean El-Cheikh Imane El Dika Radwan Massoud Maya Charafeddine Rami Mahfouz Mohamed A Kharfan-Dabaja Ali Bazarbachi

Clin Lymphoma Myeloma Leuk 2017 03 21;17(3):179-185. Epub 2016 Nov 21.

Bone Marrow Transplantation Program, Department of Internal Medicine, American University of Beirut Medical Center, Beirut, Lebanon.

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March 2017

Hepatocellular carcinoma in patients with HIV.

Authors:
Imane El Dika James J Harding Ghassan K Abou-Alfa

Curr Opin HIV AIDS 2017 01;12(1):20-25

aMemorial Sloan Kettering Cancer Center bWeill Cornell Medical College, New York, New York, USA.

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January 2017

Leptomeningeal metastasis as initial manifestation of signet ring colorectal adenocarcinoma: a case report with review of literature.

Authors:
Rita Assi Lana Hamieh Deborah Mukherji Ali Haydar Sally Temraz Imane El-Dika Ali Shamseddine

J Gastrointest Oncol 2015 Dec;6(6):E89-E101

1 Department of Internal Medicine, Division of Hematology-Oncology, 2 Department of Radiology, American University of Beirut Medical Center, Beirut 1103, Lebanon.

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December 2015

Immunotherapy in hepatocellular carcinoma: Primed to make a difference?

Authors:
James J Harding Imane El Dika Ghassan K Abou-Alfa

Cancer 2016 Feb 5;122(3):367-77. Epub 2015 Nov 5.

Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.

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February 2016

Sunitinib Induced Thrombotic Thrombocytopenic Purpura in addition to Severe Hypothyroidism: A Case Report and Review of the Literature.

Authors:
Imane El Dika Deborah Mukherji Sally Temraz Rita Assi Ali Shamseddine

Case Rep Med 2014 7;2014:958414. Epub 2014 Oct 7.

Department of Internal Medicine, Division of Medical Oncology, American University of Beirut Medical Center, P.O. Box 11-0236, Riad El-Solh, Beirut 1107 2020, Lebanon.

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October 2014

Evolving treatment approaches for the management of metastatic castration-resistant prostate cancer - role of radium-223.

Authors:
Deborah Mukherji Imane El Dika Sally Temraz Mohammed Haidar Ali Shamseddine

Ther Clin Risk Manag 2014 23;10:373-80. Epub 2014 May 23.

Department of Hematology/Oncology, American University of Beirut Medical Center, Beirut, Lebanon.

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June 2014