Ilya Gukovsky

Ilya Gukovsky

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Ilya Gukovsky

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Cathepsin B-Mediated Activation of Trypsinogen in Endocytosing Macrophages Increases Severity of Pancreatitis in Mice.

Gastroenterology 2018 02 10;154(3):704-718.e10. Epub 2018 Jan 10.

Department of Medicine A, University Medicine Greifswald, Greifswald, Germany; Medizinische Klinik und Poliklinik II, Universitätsklinikum der Ludwig-Maximilians-Universität, Klinikum Grosshadern, Munich, Germany. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00165085173627
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http://dx.doi.org/10.1053/j.gastro.2017.10.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6663074PMC
February 2018

Human Pancreatic Acinar Cells: Proteomic Characterization, Physiologic Responses, and Organellar Disorders in ex Vivo Pancreatitis.

Am J Pathol 2017 Dec 19;187(12):2726-2743. Epub 2017 Sep 19.

Department of Medicine and Biomedical Sciences, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California; Department of Medicine, David Geffen School of Medicine at the University of California Los Angeles, Los Angeles, California; Veterans Administration Greater Los Angeles Healthcare System, Los Angeles, California.

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http://dx.doi.org/10.1016/j.ajpath.2017.08.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5718097PMC
December 2017

Autophagy, Inflammation, and Immune Dysfunction in the Pathogenesis of Pancreatitis.

Gastroenterology 2017 11 14;153(5):1212-1226. Epub 2017 Sep 14.

Division of Gastroenterology and Hepatology, Stanford University School of Medicine, Stanford, California.

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http://dx.doi.org/10.1053/j.gastro.2017.08.071DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6338477PMC
November 2017

New insights into the pathways initiating and driving pancreatitis.

Curr Opin Gastroenterol 2016 Sep;32(5):429-435

aUniversity of California; VA Greater Los Angeles Healthcare System bCedars-Sinai Medical Center, Los Angeles, California, USA.

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http://dx.doi.org/10.1097/MOG.0000000000000301DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5235997PMC
September 2016

Basal autophagy maintains pancreatic acinar cell homeostasis and protein synthesis and prevents ER stress.

Proc Natl Acad Sci U S A 2015 Nov 28;112(45):E6166-74. Epub 2015 Oct 28.

Laboratory of Gene Regulation and Signal Transduction, Departments of Pharmacology and Pathology, Moores Cancer Center, University of California, San Diego (UCSD) School of Medicine, La Jolla CA 92093-0636;

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http://dx.doi.org/10.1073/pnas.1519384112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4653219PMC
November 2015

Impaired autophagy triggers chronic pancreatitis: lessons from pancreas-specific atg5 knockout mice.

Gastroenterology 2015 Mar 19;148(3):501-5. Epub 2015 Jan 19.

VA Greater Los Angeles Healthcare System and University of California at Los Angeles, Los Angeles, California.

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http://dx.doi.org/10.1053/j.gastro.2015.01.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4443443PMC
March 2015

Loss of acinar cell IKKα triggers spontaneous pancreatitis in mice.

J Clin Invest 2013 May 8;123(5):2231-43. Epub 2013 Apr 8.

Laboratory of Gene Regulation and Signal Transduction, Departments of Pharmacology and Pathology, School of Medicine, UCSD, La Jolla, California 92093-0723, USA.

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http://dx.doi.org/10.1172/JCI64498DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3635720PMC
May 2013

Autophagy and pancreatitis.

Am J Physiol Gastrointest Liver Physiol 2012 Nov 6;303(9):G993-G1003. Epub 2012 Sep 6.

Veterans Affairs Greater Los Angeles Healthcare System and University of California at Los Angeles, Los Angeles, CA 90073, USA.

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http://dx.doi.org/10.1152/ajpgi.00122.2012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3517664PMC
November 2012

Protein kinase d regulates cell death pathways in experimental pancreatitis.

Front Physiol 2012 27;3:60. Epub 2012 Mar 27.

South California Research Center for Alcoholic Liver and Pancreatic Diseases, Veterans Affairs Greater Los Angeles Healthcare System, University of California at Los Angeles Los Angeles, CA, USA.

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http://dx.doi.org/10.3389/fphys.2012.00060DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3313474PMC
October 2012

Guidelines for the use and interpretation of assays for monitoring autophagy.

Authors:
Daniel J Klionsky Fabio C Abdalla Hagai Abeliovich Robert T Abraham Abraham Acevedo-Arozena Khosrow Adeli Lotta Agholme Maria Agnello Patrizia Agostinis Julio A Aguirre-Ghiso Hyung Jun Ahn Ouardia Ait-Mohamed Slimane Ait-Si-Ali Takahiko Akematsu Shizuo Akira Hesham M Al-Younes Munir A Al-Zeer Matthew L Albert Roger L Albin Javier Alegre-Abarrategui Maria Francesca Aleo Mehrdad Alirezaei Alexandru Almasan Maylin Almonte-Becerril Atsuo Amano Ravi Amaravadi Shoba Amarnath Amal O Amer Nathalie Andrieu-Abadie Vellareddy Anantharam David K Ann Shailendra Anoopkumar-Dukie Hiroshi Aoki Nadezda Apostolova Giuseppe Arancia John P Aris Katsuhiko Asanuma Nana Y O Asare Hisashi Ashida Valerie Askanas David S Askew Patrick Auberger Misuzu Baba Steven K Backues Eric H Baehrecke Ben A Bahr Xue-Yuan Bai Yannick Bailly Robert Baiocchi Giulia Baldini Walter Balduini Andrea Ballabio Bruce A Bamber Edward T W Bampton Gábor Bánhegyi Clinton R Bartholomew Diane C Bassham Robert C Bast Henri Batoko Boon-Huat Bay Isabelle Beau Daniel M Béchet Thomas J Begley Christian Behl Christian Behrends Soumeya Bekri Bryan Bellaire Linda J Bendall Luca Benetti Laura Berliocchi Henri Bernardi Francesca Bernassola Sébastien Besteiro Ingrid Bhatia-Kissova Xiaoning Bi Martine Biard-Piechaczyk Janice S Blum Lawrence H Boise Paolo Bonaldo David L Boone Beat C Bornhauser Karina R Bortoluci Ioannis Bossis Frédéric Bost Jean-Pierre Bourquin Patricia Boya Michaël Boyer-Guittaut Peter V Bozhkov Nathan R Brady Claudio Brancolini Andreas Brech Jay E Brenman Ana Brennand Emery H Bresnick Patrick Brest Dave Bridges Molly L Bristol Paul S Brookes Eric J Brown John H Brumell Nicola Brunetti-Pierri Ulf T Brunk Dennis E Bulman Scott J Bultman Geert Bultynck Lena F Burbulla Wilfried Bursch Jonathan P Butchar Wanda Buzgariu Sergio P Bydlowski Ken Cadwell Monika Cahová Dongsheng Cai Jiyang Cai Qian Cai Bruno Calabretta Javier Calvo-Garrido Nadine Camougrand Michelangelo Campanella Jenny Campos-Salinas Eleonora Candi Lizhi Cao Allan B Caplan Simon R Carding Sandra M Cardoso Jennifer S Carew Cathleen R Carlin Virginie Carmignac Leticia A M Carneiro Serena Carra Rosario A Caruso Giorgio Casari Caty Casas Roberta Castino Eduardo Cebollero Francesco Cecconi Jean Celli Hassan Chaachouay Han-Jung Chae Chee-Yin Chai David C Chan Edmond Y Chan Raymond Chuen-Chung Chang Chi-Ming Che Ching-Chow Chen Guang-Chao Chen Guo-Qiang Chen Min Chen Quan Chen Steve S-L Chen WenLi Chen Xi Chen Xiangmei Chen Xiequn Chen Ye-Guang Chen Yingyu Chen Yongqiang Chen Yu-Jen Chen Zhixiang Chen Alan Cheng Christopher H K Cheng Yan Cheng Heesun Cheong Jae-Ho Cheong Sara Cherry Russ Chess-Williams Zelda H Cheung Eric Chevet Hui-Ling Chiang Roberto Chiarelli Tomoki Chiba Lih-Shen Chin Shih-Hwa Chiou Francis V Chisari Chi Hin Cho Dong-Hyung Cho Augustine M K Choi DooSeok Choi Kyeong Sook Choi Mary E Choi Salem Chouaib Divaker Choubey Vinay Choubey Charleen T Chu Tsung-Hsien Chuang Sheau-Huei Chueh Taehoon Chun Yong-Joon Chwae Mee-Len Chye Roberto Ciarcia Maria R Ciriolo Michael J Clague Robert S B Clark Peter G H Clarke Robert Clarke Patrice Codogno Hilary A Coller María I Colombo Sergio Comincini Maria Condello Fabrizio Condorelli Mark R Cookson Graham H Coombs Isabelle Coppens Ramon Corbalan Pascale Cossart Paola Costelli Safia Costes Ana Coto-Montes Eduardo Couve Fraser P Coxon James M Cregg José L Crespo Marianne J Cronjé Ana Maria Cuervo Joseph J Cullen Mark J Czaja Marcello D'Amelio Arlette Darfeuille-Michaud Lester M Davids Faith E Davies Massimo De Felici John F de Groot Cornelis A M de Haan Luisa De Martino Angelo De Milito Vincenzo De Tata Jayanta Debnath Alexei Degterev Benjamin Dehay Lea M D Delbridge Francesca Demarchi Yi Zhen Deng Jörn Dengjel Paul Dent Donna Denton Vojo Deretic Shyamal D Desai Rodney J Devenish Mario Di Gioacchino Gilbert Di Paolo Chiara Di Pietro Guillermo Díaz-Araya Inés Díaz-Laviada Maria T Diaz-Meco Javier Diaz-Nido Ivan Dikic Savithramma P Dinesh-Kumar Wen-Xing Ding Clark W Distelhorst Abhinav Diwan Mojgan Djavaheri-Mergny Svetlana Dokudovskaya Zheng Dong Frank C Dorsey Victor Dosenko James J Dowling Stephen Doxsey Marlène Dreux Mark E Drew Qiuhong Duan Michel A Duchosal Karen Duff Isabelle Dugail Madeleine Durbeej Michael Duszenko Charles L Edelstein Aimee L Edinger Gustavo Egea Ludwig Eichinger N Tony Eissa Suhendan Ekmekcioglu Wafik S El-Deiry Zvulun Elazar Mohamed Elgendy Lisa M Ellerby Kai Er Eng Anna-Mart Engelbrecht Simone Engelender Jekaterina Erenpreisa Ricardo Escalante Audrey Esclatine Eeva-Liisa Eskelinen Lucile Espert Virginia Espina Huizhou Fan Jia Fan Qi-Wen Fan Zhen Fan Shengyun Fang Yongqi Fang Manolis Fanto Alessandro Fanzani Thomas Farkas Jean-Claude Farré Mathias Faure Marcus Fechheimer Carl G Feng Jian Feng Qili Feng Youji Feng László Fésüs Ralph Feuer Maria E Figueiredo-Pereira Gian Maria Fimia Diane C Fingar Steven Finkbeiner Toren Finkel Kim D Finley Filomena Fiorito Edward A Fisher Paul B Fisher Marc Flajolet Maria L Florez-McClure Salvatore Florio Edward A Fon Francesco Fornai Franco Fortunato Rati Fotedar Daniel H Fowler Howard S Fox Rodrigo Franco Lisa B Frankel Marc Fransen José M Fuentes Juan Fueyo Jun Fujii Kozo Fujisaki Eriko Fujita Mitsunori Fukuda Ruth H Furukawa Matthias Gaestel Philippe Gailly Malgorzata Gajewska Brigitte Galliot Vincent Galy Subramaniam Ganesh Barry Ganetzky Ian G Ganley Fen-Biao Gao George F Gao Jinming Gao Lorena Garcia Guillermo Garcia-Manero Mikel Garcia-Marcos Marjan Garmyn Andrei L Gartel Evelina Gatti Mathias Gautel Thomas R Gawriluk Matthew E Gegg Jiefei Geng Marc Germain Jason E Gestwicki David A Gewirtz Saeid Ghavami Pradipta Ghosh Anna M Giammarioli Alexandra N Giatromanolaki Spencer B Gibson Robert W Gilkerson Michael L Ginger Henry N Ginsberg Jakub Golab Michael S Goligorsky Pierre Golstein Candelaria Gomez-Manzano Ebru Goncu Céline Gongora Claudio D Gonzalez Ramon Gonzalez Cristina González-Estévez Rosa Ana González-Polo Elena Gonzalez-Rey Nikolai V Gorbunov Sharon Gorski Sandro Goruppi Roberta A Gottlieb Devrim Gozuacik Giovanna Elvira Granato Gary D Grant Kim N Green Aleš Gregorc Frédéric Gros Charles Grose Thomas W Grunt Philippe Gual Jun-Lin Guan Kun-Liang Guan Sylvie M Guichard Anna S Gukovskaya Ilya Gukovsky Jan Gunst Asa B Gustafsson Andrew J Halayko Amber N Hale Sandra K Halonen Maho Hamasaki Feng Han Ting Han Michael K Hancock Malene Hansen Hisashi Harada Masaru Harada Stefan E Hardt J Wade Harper Adrian L Harris James Harris Steven D Harris Makoto Hashimoto Jeffrey A Haspel Shin-ichiro Hayashi Lori A Hazelhurst Congcong He You-Wen He Marie-Joseé Hébert Kim A Heidenreich Miep H Helfrich Gudmundur V Helgason Elizabeth P Henske Brian Herman Paul K Herman Claudio Hetz Sabine Hilfiker Joseph A Hill Lynne J Hocking Paul Hofman Thomas G Hofmann Jörg Höhfeld Tessa L Holyoake Ming-Huang Hong David A Hood Gökhan S Hotamisligil Ewout J Houwerzijl Maria Høyer-Hansen Bingren Hu Chien-An A Hu Hong-Ming Hu Ya Hua Canhua Huang Ju Huang Shengbing Huang Wei-Pang Huang Tobias B Huber Won-Ki Huh Tai-Ho Hung Ted R Hupp Gang Min Hur James B Hurley Sabah N A Hussain Patrick J Hussey Jung Jin Hwang Seungmin Hwang Atsuhiro Ichihara Shirin Ilkhanizadeh Ken Inoki Takeshi Into Valentina Iovane Juan L Iovanna Nancy Y Ip Yoshitaka Isaka Hiroyuki Ishida Ciro Isidoro Ken-ichi Isobe Akiko Iwasaki Marta Izquierdo Yotaro Izumi Panu M Jaakkola Marja Jäättelä George R Jackson William T Jackson Bassam Janji Marina Jendrach Ju-Hong Jeon Eui-Bae Jeung Hong Jiang Hongchi Jiang Jean X Jiang Ming Jiang Qing Jiang Xuejun Jiang Xuejun Jiang Alberto Jiménez Meiyan Jin Shengkan Jin Cheol O Joe Terje Johansen Daniel E Johnson Gail V W Johnson Nicola L Jones Bertrand Joseph Suresh K Joseph Annie M Joubert Gábor Juhász Lucienne Juillerat-Jeanneret Chang Hwa Jung Yong-Keun Jung Kai Kaarniranta Allen Kaasik Tomohiro Kabuta Motoni Kadowaki Katarina Kagedal Yoshiaki Kamada Vitaliy O Kaminskyy Harm H Kampinga Hiromitsu Kanamori Chanhee Kang Khong Bee Kang Kwang Il Kang Rui Kang Yoon-A Kang Tomotake Kanki Thirumala-Devi Kanneganti Haruo Kanno Anumantha G Kanthasamy Arthi Kanthasamy Vassiliki Karantza Gur P Kaushal Susmita Kaushik Yoshinori Kawazoe Po-Yuan Ke John H Kehrl Ameeta Kelekar Claus Kerkhoff David H Kessel Hany Khalil Jan A K W Kiel Amy A Kiger Akio Kihara Deok Ryong Kim Do-Hyung Kim Dong-Hou Kim Eun-Kyoung Kim Hyung-Ryong Kim Jae-Sung Kim Jeong Hun Kim Jin Cheon Kim John K Kim Peter K Kim Seong Who Kim Yong-Sun Kim Yonghyun Kim Adi Kimchi Alec C Kimmelman Jason S King Timothy J Kinsella Vladimir Kirkin Lorrie A Kirshenbaum Katsuhiko Kitamoto Kaio Kitazato Ludger Klein Walter T Klimecki Jochen Klucken Erwin Knecht Ben C B Ko Jan C Koch Hiroshi Koga Jae-Young Koh Young Ho Koh Masato Koike Masaaki Komatsu Eiki Kominami Hee Jeong Kong Wei-Jia Kong Viktor I Korolchuk Yaichiro Kotake Michael I Koukourakis Juan B Kouri Flores Attila L Kovács Claudine Kraft Dimitri Krainc Helmut Krämer Carole Kretz-Remy Anna M Krichevsky Guido Kroemer Rejko Krüger Oleg Krut Nicholas T Ktistakis Chia-Yi Kuan Roza Kucharczyk Ashok Kumar Raj Kumar Sharad Kumar Mondira Kundu Hsing-Jien Kung Tino Kurz Ho Jeong Kwon Albert R La Spada Frank Lafont Trond Lamark Jacques Landry Jon D Lane Pierre Lapaquette Jocelyn F Laporte Lajos László Sergio Lavandero Josée N Lavoie Robert Layfield Pedro A Lazo Weidong Le Laurent Le Cam Daniel J Ledbetter Alvin J X Lee Byung-Wan Lee Gyun Min Lee Jongdae Lee Ju-Hyun Lee Michael Lee Myung-Shik Lee Sug Hyung Lee Christiaan Leeuwenburgh Patrick Legembre Renaud Legouis Michael Lehmann Huan-Yao Lei Qun-Ying Lei David A Leib José Leiro John J Lemasters Antoinette Lemoine Maciej S Lesniak Dina Lev Victor V Levenson Beth Levine Efrat Levy Faqiang Li Jun-Lin Li Lian Li Sheng Li Weijie Li Xue-Jun Li Yan-bo Li Yi-Ping Li Chengyu Liang Qiangrong Liang Yung-Feng Liao Pawel P Liberski Andrew Lieberman Hyunjung J Lim Kah-Leong Lim Kyu Lim Chiou-Feng Lin Fu-Cheng Lin Jian Lin Jiandie D Lin Kui Lin Wan-Wan Lin Weei-Chin Lin Yi-Ling Lin Rafael Linden Paul Lingor Jennifer Lippincott-Schwartz Michael P Lisanti Paloma B Liton Bo Liu Chun-Feng Liu Kaiyu Liu Leyuan Liu Qiong A Liu Wei Liu Young-Chau Liu Yule Liu Richard A Lockshin Chun-Nam Lok Sagar Lonial Benjamin Loos Gabriel Lopez-Berestein Carlos López-Otín Laura Lossi Michael T Lotze Peter Lőw Binfeng Lu Bingwei Lu Bo Lu Zhen Lu Frédéric Luciano Nicholas W Lukacs Anders H Lund Melinda A Lynch-Day Yong Ma Fernando Macian Jeff P MacKeigan Kay F Macleod Frank Madeo Luigi Maiuri Maria Chiara Maiuri Davide Malagoli May Christine V Malicdan Walter Malorni Na Man Eva-Maria Mandelkow Stéphen Manon Irena Manov Kai Mao Xiang Mao Zixu Mao Philippe Marambaud Daniela Marazziti Yves L Marcel Katie Marchbank Piero Marchetti Stefan J Marciniak Mateus Marcondes Mohsen Mardi Gabriella Marfe Guillermo Mariño Maria Markaki Mark R Marten Seamus J Martin Camille Martinand-Mari Wim Martinet Marta Martinez-Vicente Matilde Masini Paola Matarrese Saburo Matsuo Raffaele Matteoni Andreas Mayer Nathalie M Mazure David J McConkey Melanie J McConnell Catherine McDermott Christine McDonald Gerald M McInerney Sharon L McKenna BethAnn McLaughlin Pamela J McLean Christopher R McMaster G Angus McQuibban Alfred J Meijer Miriam H Meisler Alicia Meléndez Thomas J Melia Gerry Melino Maria A Mena Javier A Menendez Rubem F S Menna-Barreto Manoj B Menon Fiona M Menzies Carol A Mercer Adalberto Merighi Diane E Merry Stefania Meschini Christian G Meyer Thomas F Meyer Chao-Yu Miao Jun-Ying Miao Paul A M Michels Carine Michiels Dalibor Mijaljica Ana Milojkovic Saverio Minucci Clelia Miracco Cindy K Miranti Ioannis Mitroulis Keisuke Miyazawa Noboru Mizushima Baharia Mograbi Simin Mohseni Xavier Molero Bertrand Mollereau Faustino Mollinedo Takashi Momoi Iryna Monastyrska Martha M Monick Mervyn J Monteiro Michael N Moore Rodrigo Mora Kevin Moreau Paula I Moreira Yuji Moriyasu Jorge Moscat Serge Mostowy Jeremy C Mottram Tomasz Motyl Charbel E-H Moussa Sylke Müller Sylviane Muller Karl Münger Christian Münz Leon O Murphy Maureen E Murphy Antonio Musarò Indira Mysorekar Eiichiro Nagata Kazuhiro Nagata Aimable Nahimana Usha Nair Toshiyuki Nakagawa Kiichi Nakahira Hiroyasu Nakano Hitoshi Nakatogawa Meera Nanjundan Naweed I Naqvi Derek P Narendra Masashi Narita Miguel Navarro Steffan T Nawrocki Taras Y Nazarko Andriy Nemchenko Mihai G Netea Thomas P Neufeld Paul A Ney Ioannis P Nezis Huu Phuc Nguyen Daotai Nie Ichizo Nishino Corey Nislow Ralph A Nixon Takeshi Noda Angelika A Noegel Anna Nogalska Satoru Noguchi Lucia Notterpek Ivana Novak Tomoyoshi Nozaki Nobuyuki Nukina Thorsten Nürnberger Beat Nyfeler Keisuke Obara Terry D Oberley Salvatore Oddo Michinaga Ogawa Toya Ohashi Koji Okamoto Nancy L Oleinick F Javier Oliver Laura J Olsen Stefan Olsson Onya Opota Timothy F Osborne Gary K Ostrander Kinya Otsu Jing-hsiung James Ou Mireille Ouimet Michael Overholtzer Bulent Ozpolat Paolo Paganetti Ugo Pagnini Nicolas Pallet Glen E Palmer Camilla Palumbo Tianhong Pan Theocharis Panaretakis Udai Bhan Pandey Zuzana Papackova Issidora Papassideri Irmgard Paris Junsoo Park Ohkmae K Park Jan B Parys Katherine R Parzych Susann Patschan Cam Patterson Sophie Pattingre John M Pawelek Jianxin Peng David H Perlmutter Ida Perrotta George Perry Shazib Pervaiz Matthias Peter Godefridus J Peters Morten Petersen Goran Petrovski James M Phang Mauro Piacentini Philippe Pierre Valérie Pierrefite-Carle Gérard Pierron Ronit Pinkas-Kramarski Antonio Piras Natik Piri Leonidas C Platanias Stefanie Pöggeler Marc Poirot Angelo Poletti Christian Poüs Mercedes Pozuelo-Rubio Mette Prætorius-Ibba Anil Prasad Mark Prescott Muriel Priault Nathalie Produit-Zengaffinen Ann Progulske-Fox Tassula Proikas-Cezanne Serge Przedborski Karin Przyklenk Rosa Puertollano Julien Puyal Shu-Bing Qian Liang Qin Zheng-Hong Qin Susan E Quaggin Nina Raben Hannah Rabinowich Simon W Rabkin Irfan Rahman Abdelhaq Rami Georg Ramm Glenn Randall Felix Randow V Ashutosh Rao Jeffrey C Rathmell Brinda Ravikumar Swapan K Ray Bruce H Reed John C Reed Fulvio Reggiori Anne Régnier-Vigouroux Andreas S Reichert John J Reiners Russel J Reiter Jun Ren José L Revuelta Christopher J Rhodes Konstantinos Ritis Elizete Rizzo Jeffrey Robbins Michel Roberge Hernan Roca Maria C Roccheri Stephane Rocchi H Peter Rodemann Santiago Rodríguez de Córdoba Bärbel Rohrer Igor B Roninson Kirill Rosen Magdalena M Rost-Roszkowska Mustapha Rouis Kasper M A Rouschop Francesca Rovetta Brian P Rubin David C Rubinsztein Klaus Ruckdeschel Edmund B Rucker Assaf Rudich Emil Rudolf Nelson Ruiz-Opazo Rossella Russo Tor Erik Rusten Kevin M Ryan Stefan W Ryter David M Sabatini Junichi Sadoshima Tapas Saha Tatsuya Saitoh Hiroshi Sakagami Yasuyoshi Sakai Ghasem Hoseini Salekdeh Paolo Salomoni Paul M Salvaterra Guy Salvesen Rosa Salvioli Anthony M J Sanchez José A Sánchez-Alcázar Ricardo Sánchez-Prieto Marco Sandri Uma Sankar Poonam Sansanwal Laura Santambrogio Shweta Saran Sovan Sarkar Minnie Sarwal Chihiro Sasakawa Ausra Sasnauskiene Miklós Sass Ken Sato Miyuki Sato Anthony H V Schapira Michael Scharl Hermann M Schätzl Wiep Scheper Stefano Schiaffino Claudio Schneider Marion E Schneider Regine Schneider-Stock Patricia V Schoenlein Daniel F Schorderet Christoph Schüller Gary K Schwartz Luca Scorrano Linda Sealy Per O Seglen Juan Segura-Aguilar Iban Seiliez Oleksandr Seleverstov Christian Sell Jong Bok Seo Duska Separovic Vijayasaradhi Setaluri Takao Setoguchi Carmine Settembre John J Shacka Mala Shanmugam Irving M Shapiro Eitan Shaulian Reuben J Shaw James H Shelhamer Han-Ming Shen Wei-Chiang Shen Zu-Hang Sheng Yang Shi Kenichi Shibuya Yoshihiro Shidoji Jeng-Jer Shieh Chwen-Ming Shih Yohta Shimada Shigeomi Shimizu Takahiro Shintani Orian S Shirihai Gordon C Shore Andriy A Sibirny Stan B Sidhu Beata Sikorska Elaine C M Silva-Zacarin Alison Simmons Anna Katharina Simon Hans-Uwe Simon Cristiano Simone Anne Simonsen David A Sinclair Rajat Singh Debasish Sinha Frank A Sinicrope Agnieszka Sirko Parco M Siu Efthimios Sivridis Vojtech Skop Vladimir P Skulachev Ruth S Slack Soraya S Smaili Duncan R Smith Maria S Soengas Thierry Soldati Xueqin Song Anil K Sood Tuck Wah Soong Federica Sotgia Stephen A Spector Claudia D Spies Wolfdieter Springer Srinivasa M Srinivasula Leonidas Stefanis Joan S Steffan Ruediger Stendel Harald Stenmark Anastasis Stephanou Stephan T Stern Cinthya Sternberg Björn Stork Peter Strålfors Carlos S Subauste Xinbing Sui David Sulzer Jiaren Sun Shi-Yong Sun Zhi-Jun Sun Joseph J Y Sung Kuninori Suzuki Toshihiko Suzuki Michele S Swanson Charles Swanton Sean T Sweeney Lai-King Sy Gyorgy Szabadkai Ira Tabas Heinrich Taegtmeyer Marco Tafani Krisztina Takács-Vellai Yoshitaka Takano Kaoru Takegawa Genzou Takemura Fumihiko Takeshita Nicholas J Talbot Kevin S W Tan Keiji Tanaka Kozo Tanaka Daolin Tang Dingzhong Tang Isei Tanida Bakhos A Tannous Nektarios Tavernarakis Graham S Taylor Gregory A Taylor J Paul Taylor Lance S Terada Alexei Terman Gianluca Tettamanti Karin Thevissen Craig B Thompson Andrew Thorburn Michael Thumm FengFeng Tian Yuan Tian Glauco Tocchini-Valentini Aviva M Tolkovsky Yasuhiko Tomino Lars Tönges Sharon A Tooze Cathy Tournier John Tower Roberto Towns Vladimir Trajkovic Leonardo H Travassos Ting-Fen Tsai Mario P Tschan Takeshi Tsubata Allan Tsung Boris Turk Lorianne S Turner Suresh C Tyagi Yasuo Uchiyama Takashi Ueno Midori Umekawa Rika Umemiya-Shirafuji Vivek K Unni Maria I Vaccaro Enza Maria Valente Greet Van den Berghe Ida J van der Klei Wouter van Doorn Linda F van Dyk Marjolein van Egmond Leo A van Grunsven Peter Vandenabeele Wim P Vandenberghe Ilse Vanhorebeek Eva C Vaquero Guillermo Velasco Tibor Vellai Jose Miguel Vicencio Richard D Vierstra Miquel Vila Cécile Vindis Giampietro Viola Maria Teresa Viscomi Olga V Voitsekhovskaja Clarissa von Haefen Marcela Votruba Keiji Wada Richard Wade-Martins Cheryl L Walker Craig M Walsh Jochen Walter Xiang-Bo Wan Aimin Wang Chenguang Wang Dawei Wang Fan Wang Fen Wang Guanghui Wang Haichao Wang Hong-Gang Wang Horng-Dar Wang Jin Wang Ke Wang Mei Wang Richard C Wang Xinglong Wang Xuejun Wang Ying-Jan Wang Yipeng Wang Zhen Wang Zhigang Charles Wang Zhinong Wang Derick G Wansink Diane M Ward Hirotaka Watada Sarah L Waters Paul Webster Lixin Wei Conrad C Weihl William A Weiss Scott M Welford Long-Ping Wen Caroline A Whitehouse J Lindsay Whitton Alexander J Whitworth Tom Wileman John W Wiley Simon Wilkinson Dieter Willbold Roger L Williams Peter R Williamson Bradly G Wouters Chenghan Wu Dao-Cheng Wu William K K Wu Andreas Wyttenbach Ramnik J Xavier Zhijun Xi Pu Xia Gengfu Xiao Zhiping Xie Zhonglin Xie Da-zhi Xu Jianzhen Xu Liang Xu Xiaolei Xu Ai Yamamoto Akitsugu Yamamoto Shunhei Yamashina Michiaki Yamashita Xianghua Yan Mitsuhiro Yanagida Dun-Sheng Yang Elizabeth Yang Jin-Ming Yang Shi Yu Yang Wannian Yang Wei Yuan Yang Zhifen Yang Meng-Chao Yao Tso-Pang Yao Behzad Yeganeh Wei-Lien Yen Jia-jing Yin Xiao-Ming Yin Ook-Joon Yoo Gyesoon Yoon Seung-Yong Yoon Tomohiro Yorimitsu Yuko Yoshikawa Tamotsu Yoshimori Kohki Yoshimoto Ho Jin You Richard J Youle Anas Younes Li Yu Long Yu Seong-Woon Yu Wai Haung Yu Zhi-Min Yuan Zhenyu Yue Cheol-Heui Yun Michisuke Yuzaki Olga Zabirnyk Elaine Silva-Zacarin David Zacks Eldad Zacksenhaus Nadia Zaffaroni Zahra Zakeri Herbert J Zeh Scott O Zeitlin Hong Zhang Hui-Ling Zhang Jianhua Zhang Jing-Pu Zhang Lin Zhang Long Zhang Ming-Yong Zhang Xu Dong Zhang Mantong Zhao Yi-Fang Zhao Ying Zhao Zhizhuang J Zhao Xiaoxiang Zheng Boris Zhivotovsky Qing Zhong Cong-Zhao Zhou Changlian Zhu Wei-Guo Zhu Xiao-Feng Zhu Xiongwei Zhu Yuangang Zhu Teresa Zoladek Wei-Xing Zong Antonio Zorzano Jürgen Zschocke Brian Zuckerbraun

Autophagy 2012 Apr;8(4):445-544

Life Sciences Institute, University of Michigan, Ann Arbor, MI, USA.

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http://www.dwalab.ca/common/pdf/cdd200944a.pdf
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3404883PMC
http://dx.doi.org/10.4161/auto.19496DOI Listing
April 2012

Impaired autophagy and organellar dysfunction in pancreatitis.

J Gastroenterol Hepatol 2012 Mar;27 Suppl 2:27-32

Southern California Research Centers for Alcoholic Liver and Pancreatic Diseases and Cirrhosis, VA Greater Los Angeles Healthcare System, and University of California at Los Angeles, California 90073, USA.

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http://dx.doi.org/10.1111/j.1440-1746.2011.07004.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3281514PMC
March 2012

Organellar dysfunction in the pathogenesis of pancreatitis.

Antioxid Redox Signal 2011 Nov 11;15(10):2699-710. Epub 2011 Aug 11.

VA Greater Los Angeles Healthcare System, University of California, Los Angeles, California 90073, USA.

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http://dx.doi.org/10.1089/ars.2011.4068DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3183656PMC
November 2011

Investigating the pathobiology of alcoholic pancreatitis.

Alcohol Clin Exp Res 2011 May 1;35(5):830-7. Epub 2011 Feb 1.

Pancreatic Research Group, Department of Veterans Affairs Greater Los Angeles, University of California Los Angeles, 90073, USA.

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http://dx.doi.org/10.1111/j.1530-0277.2010.01408.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3083481PMC
May 2011

Adaptive unfolded protein response attenuates alcohol-induced pancreatic damage.

Gastroenterology 2011 Mar 25;140(3):987-97. Epub 2010 Nov 25.

Southern California Research Center for ALPD & Cirrhosis, Veterans Administration Greater Los Angeles Healthcare System/University of California, Los Angeles, California 90073, USA.

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http://dx.doi.org/10.1053/j.gastro.2010.11.038DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3057335PMC
March 2011

NADPH oxidase activation in pancreatic cancer cells is mediated through Akt-dependent up-regulation of p22phox.

J Biol Chem 2011 03 30;286(10):7779-87. Epub 2010 Nov 30.

Veterans Affairs Greater Los Angeles Healthcare System and UCLA, Los Angeles, California 90073, USA.

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http://dx.doi.org/10.1074/jbc.M110.200063DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3048665PMC
March 2011

Impaired autophagy underlies key pathological responses of acute pancreatitis.

Autophagy 2010 Apr 15;6(3):428-9. Epub 2010 Apr 15.

VA Greater Los Angeles Healthcare System and University of California, Los Angeles, Los Angeles, CA, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4580269PMC
http://dx.doi.org/10.4161/auto.6.3.11530DOI Listing
April 2010

Impaired autophagic flux mediates acinar cell vacuole formation and trypsinogen activation in rodent models of acute pancreatitis.

J Clin Invest 2009 Nov 1;119(11):3340-55. Epub 2009 Oct 1.

Veterans Affairs Greater Los Angeles Healthcare System and University of California at Los Angeles, Los Angeles, California 90073, USA.

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http://dx.doi.org/10.1172/JCI38674DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2769194PMC
November 2009

Desmoplasia of pancreatic ductal adenocarcinoma.

Clin Gastroenterol Hepatol 2009 Nov;7(11 Suppl):S44-7

Pancreatic Research Group, Department of Medicine, VA Greater Los Angeles Health Care System and University of California, Los Angeles, California, USA.

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http://dx.doi.org/10.1016/j.cgh.2009.07.039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4573641PMC
November 2009

Protein kinase D1 mediates NF-kappaB activation induced by cholecystokinin and cholinergic signaling in pancreatic acinar cells.

Am J Physiol Gastrointest Liver Physiol 2008 Dec 9;295(6):G1190-201. Epub 2008 Oct 9.

Veterans Affairs Greater Los Angeles Healthcare System, West Los Angeles VA Healthcare Center, Los Angeles, CA 90073, USA.

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http://dx.doi.org/10.1152/ajpgi.90452.2008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2604803PMC
December 2008

Ellagic acid induces apoptosis through inhibition of nuclear factor kappa B in pancreatic cancer cells.

World J Gastroenterol 2008 Jun;14(23):3672-80

Department of Medicine, Veterans Affairs Greater Los Angeles Healthcare System and University of California, Los Angeles, CA 90073, California, United States.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2719230PMC
http://dx.doi.org/10.3748/wjg.14.3672DOI Listing
June 2008

Mitochondrial mechanisms of death responses in pancreatitis.

J Gastroenterol Hepatol 2008 Mar;23 Suppl 1:S25-30

USC-UCLA Research Center for Alcoholic Liver and Pancreatic Diseases, VA Greater Los Angeles Healthcare System and University of California, Los Angeles, California 90073, USA.

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http://doi.wiley.com/10.1111/j.1440-1746.2007.05271.x
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http://dx.doi.org/10.1111/j.1440-1746.2007.05271.xDOI Listing
March 2008

A rat model reproducing key pathological responses of alcoholic chronic pancreatitis.

Am J Physiol Gastrointest Liver Physiol 2008 Jan 20;294(1):G68-79. Epub 2007 Sep 20.

UCLA/VA Greater Los Angeles Healthcare System, West Los Angeles VA Healthcare Center, Los Angeles, CA 90073, USA.

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http://dx.doi.org/10.1152/ajpgi.00006.2007DOI Listing
January 2008

Cell death in pancreatitis: effects of alcohol.

J Gastroenterol Hepatol 2006 Oct;21 Suppl 3:S10-3

Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, California 90073, USA.

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http://dx.doi.org/10.1111/j.1440-1746.2006.04571.xDOI Listing
October 2006

Ethanol feeding alters death signaling in the pancreas.

Pancreas 2006 May;32(4):351-9

USC-UCLA Research Center for Alcohol Liver and Pancreatic Diseases, University of California, Los Angeles, USA.

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http://dx.doi.org/10.1097/01.mpa.0000220859.93496.e1DOI Listing
May 2006

Cell death in pancreatitis: caspases protect from necrotizing pancreatitis.

J Biol Chem 2006 Feb 8;281(6):3370-81. Epub 2005 Dec 8.

Veterans Affairs Greater Los Angeles Healthcare System and Department of Medicine, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California 90073, USA.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M511276200
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February 2006

PKC-delta and -epsilon regulate NF-kappaB activation induced by cholecystokinin and TNF-alpha in pancreatic acinar cells.

Am J Physiol Gastrointest Liver Physiol 2004 Sep 29;287(3):G582-91. Epub 2004 Apr 29.

Research Center for Alcoholic Liver and Pancreatic Diseases, Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, California 90073, USA.

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http://dx.doi.org/10.1152/ajpgi.00087.2004DOI Listing
September 2004

Reactive oxygen species produced by NAD(P)H oxidase inhibit apoptosis in pancreatic cancer cells.

J Biol Chem 2004 Aug 23;279(33):34643-54. Epub 2004 May 23.

Departments of Medicine, Veterans Affairs Greater Los Angeles Healthcare System, 11301 Wilshire Boulevard, Los Angeles, CA 90073, USA.

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http://dx.doi.org/10.1074/jbc.M400078200DOI Listing
August 2004

Ethanol differentially regulates NF-kappaB activation in pancreatic acinar cells through calcium and protein kinase C pathways.

Am J Physiol Gastrointest Liver Physiol 2004 Feb 4;286(2):G204-13. Epub 2003 Sep 4.

UCLA/VA Greater Los Angeles Healthcare System, West Los Angeles Center, Los Angeles, CA 90073, USA.

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http://dx.doi.org/10.1152/ajpgi.00088.2003DOI Listing
February 2004

Phosphatidylinositide 3-kinase gamma regulates key pathologic responses to cholecystokinin in pancreatic acinar cells.

Gastroenterology 2004 Feb;126(2):554-66

Department of Medicine, VA Greater Los Angeles Healthcare Sysytem and University of California, Los Angeles, 90073, USA.

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http://dx.doi.org/10.1053/j.gastro.2003.11.017DOI Listing
February 2004

Nonoxidative ethanol metabolites alter extracellular matrix protein content in rat pancreas.

Gastroenterology 2003 Dec;125(6):1845-59

University of Southern California-University of California Research Center for Alcoholic Liver and Pancreatic Diseases, Veterans Affairs Greater Los Angeles Healthcare System, 90073, USA.

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http://dx.doi.org/10.1053/j.gastro.2003.09.021DOI Listing
December 2003

Emerging concepts for the mechanism of alcoholic pancreatitis from experimental models.

J Gastroenterol 2003 ;38(7):623-8

Department of Medicine, Veterans Affairs Greater Los Angeles Healthcare System, West Los Angeles Healthcare Center, Building 258, Room 340, 11301 Wilshire Boulevard, Los Angeles, CA 90073, USA.

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http://dx.doi.org/10.1007/s00535-003-1134-7DOI Listing
November 2003

Animal and in vitro models of alcoholic pancreatitis: role of cholecystokinin.

Pancreas 2003 Nov;27(4):297-300

Department of Medicine, Veterans Affairs Greater Los Angeles Healthcare System and University of California, Los Angeles, USC-UCLA Research Center for Alcoholic Liver and Pancreatic Diseases, California 90073, USA.

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http://dx.doi.org/10.1097/00006676-200311000-00004DOI Listing
November 2003

Extracellular matrix proteins protect pancreatic cancer cells from death via mitochondrial and nonmitochondrial pathways.

Gastroenterology 2003 Oct;125(4):1188-202

Department of Medicine, Veterans Affairs Greater Los Angeles Healthcare System and University of California, Los Angeles, California 90073, USA.

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http://dx.doi.org/10.1016/s0016-5085(03)01203-4DOI Listing
October 2003

Role of S-adenosylmethionine in two experimental models of pancreatitis.

FASEB J 2003 Jan 1;17(1):56-8. Epub 2002 Nov 1.

Division of Gastroenterology and Liver Diseases, USC Liver Disease Research Center, Keck School of Medicine USC, Los Angeles, California 90033, USA.

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http://www.fasebj.org/content/17/1/56.full.pdf
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http://www.fasebj.org/cgi/doi/10.1096/fj.01-0752fje
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January 2003

Curcumin ameliorates ethanol and nonethanol experimental pancreatitis.

Am J Physiol Gastrointest Liver Physiol 2003 Jan;284(1):G85-95

Research Center for Alcoholic Liver and Pancreatic Diseases and Department of Medicine, University of California, Los Angeles and Veterans Affairs Greater Los Angeles Healthcare System, 90073, USA.

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http://dx.doi.org/10.1152/ajpgi.00138.2002DOI Listing
January 2003

Cholecystokinin induces caspase activation and mitochondrial dysfunction in pancreatic acinar cells. Roles in cell injury processes of pancreatitis.

J Biol Chem 2002 Jun 18;277(25):22595-604. Epub 2002 Apr 18.

Department of Medicine, Veterans Affairs Greater Los Angeles Healthcare System and the UCLA, Los Angeles, California 90073, USA.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M202929200
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http://dx.doi.org/10.1074/jbc.M202929200DOI Listing
June 2002

Ethanol metabolism and transcription factor activation in pancreatic acinar cells in rats.

Gastroenterology 2002 Jan;122(1):106-18

Department of Medicine, Veterans Affairs Greater Los Angeles Healthcare System and University of California, Los Angeles 90073, California, USA.

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http://dx.doi.org/10.1053/gast.2002.30302DOI Listing
January 2002