Ilya Bezprozvanny

Ilya Bezprozvanny

UNVERIFIED PROFILE

Are you Ilya Bezprozvanny?   Register this Author

Register author
Ilya Bezprozvanny

Ilya Bezprozvanny

Publications by authors named "Ilya Bezprozvanny"

Are you Ilya Bezprozvanny?   Register this Author

100Publications

1118Reads

8Profile Views

Mutational Analysis of Sigma-1 Receptor's Role in Synaptic Stability.

Front Neurosci 2019 19;13:1012. Epub 2019 Sep 19.

Department of Physiology, UT Southwestern Medical Center, Dallas, TX, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fnins.2019.01012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6761230PMC
September 2019

Molecular Mechanisms and Therapeutics for Spinocerebellar Ataxia Type 2.

Neurotherapeutics 2019 Aug 21. Epub 2019 Aug 21.

Laboratory of Molecular Neurodegeneration, Peter the Great St.Petersburg Polytechnic University, St. Petersburg, 195251, Russia.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s13311-019-00777-6DOI Listing
August 2019

Neuronal Sigma-1 Receptors: Signaling Functions and Protective Roles in Neurodegenerative Diseases.

Front Neurosci 2019 28;13:862. Epub 2019 Aug 28.

Department of Physiology, UT Southwestern Medical Center at Dallas, Dallas, TX, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fnins.2019.00862DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6736580PMC
August 2019

Antagonist of neuronal store-operated calcium entry exerts beneficial effects in neurons expressing PSEN1ΔE9 mutant linked to familial Alzheimer disease.

Neuroscience 2019 07 2;410:118-127. Epub 2019 May 2.

Peter the Great St. Petersburg Polytechnic University, Department of Medical Physics, Laboratory of Molecular Neurodegeneration, St Petersburg, Russia. Electronic address:

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S03064522193029
Publisher Site
http://dx.doi.org/10.1016/j.neuroscience.2019.04.043DOI Listing
July 2019

Pridopidine stabilizes mushroom spines in mouse models of Alzheimer's disease by acting on the sigma-1 receptor.

Neurobiol Dis 2019 04 27;124:489-504. Epub 2018 Dec 27.

Department of Physiology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Laboratory of Molecular Neurodegeneration, Peter the Great St. Petersburg Polytechnic University, St. Petersburg, Russia. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.nbd.2018.12.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363865PMC
April 2019

Derivatives of Piperazines as Potential Therapeutic Agents for Alzheimer's Disease.

Mol Pharmacol 2019 04 29;95(4):337-348. Epub 2019 Jan 29.

Laboratory of Molecular Neurodegeneration, Department of Medical Physics, Peter the Great St. Petersburg Polytechnic University, St. Petersburg, Russian Federation (E.P., D.C., I.B.); Department of Physiology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas (H.Z., I.B.); Laboratory of Molecular Mechanisms of Neural Interactions, Sechenov Institute of Evolutionary Physiology and Biochemistry of the Russian Academy of Sciences, St. Petersburg, Russian Federation (T.Y.P., A.V.Z.); VVS Laboratory Inc., Ulica Dostoevskogo 44, St. Petersburg, Russian Federation (K.P., E.F.); Institute of Biomedical Chemistry, Moscow, Russian Federation (V.P.)

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1124/mol.118.114348DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6402417PMC
April 2019

Amyloid β perturbs elevated heme flux induced with neuronal development.

Alzheimers Dement (N Y) 2019 22;5:27-37. Epub 2019 Jan 22.

Department of Biological Sciences, University of Texas at Dallas, Richardson, TX, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.trci.2018.12.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6352316PMC
January 2019

Inositol 1,4,5-trisphosphate receptors and neurodegenerative disorders.

FEBS J 2018 10 12;285(19):3547-3565. Epub 2018 Jan 12.

Laboratory of Molecular Neurodegeneration, Peter the Great St. Petersburg Polytechnic University, St Petersburg, Russia.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/febs.14366DOI Listing
October 2018

In Vivo Analysis of the Climbing Fiber-Purkinje Cell Circuit in SCA2-58Q Transgenic Mouse Model.

Cerebellum 2018 Oct;17(5):590-600

Laboratory of Molecular Neurodegeneration, Peter the Great St. Petersburg Polytechnic University, St. Petersburg, Russia.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12311-018-0951-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6281806PMC
October 2018

Dysregulation of Intracellular Calcium Signaling in Alzheimer's Disease.

Antioxid Redox Signal 2018 10 3;29(12):1176-1188. Epub 2018 Aug 3.

1 Laboratory of Molecular Neurodegeneration, Department of Medical Physics, Peter the Great St.Petersburg Polytechnic University , St.Petersburg, Russian Federation.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1089/ars.2018.7506DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6157344PMC
October 2018

Calcium signaling and molecular mechanisms underlying neurodegenerative diseases.

Cell Calcium 2018 03 30;70:87-94. Epub 2017 Jun 30.

Laboratory of Molecular Neurodegeneration, Department of Medical Physics, Peter The Great St. Petersburg Polytechnic University, St. Petersburg, Russian Federation; Department of Physiology, UT Southwestern Medical Center at Dallas, Dallas, TX, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ceca.2017.06.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5748019PMC
March 2018

Pin1 mediates Aβ-induced dendritic spine loss.

Sci Signal 2018 03 20;11(522). Epub 2018 Mar 20.

Department of Pathology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1126/scisignal.aap8734DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6136423PMC
March 2018

STIM proteins as regulators of neuronal store-operated calcium influx.

Neurodegener Dis Manag 2018 02 3;8(1):5-7. Epub 2018 Jan 3.

Laboratory of Molecular Neurodegeneration, Department of Medical Physics, Peter the Great St Petersburg Polytechnic University, St Petersburg, 195251, Russia.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2217/nmt-2017-0053DOI Listing
February 2018

Stim2-Eb3 Association and Morphology of Dendritic Spines in Hippocampal Neurons.

Sci Rep 2017 12 15;7(1):17625. Epub 2017 Dec 15.

Laboratory of Molecular Neurodegeneration, Department of Medical Physics, Peter the Great St. Petersburg Polytechnic University, St. Petersburg, Russian Federation.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41598-017-17762-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5732248PMC
December 2017

Dysregulation of neuronal calcium homeostasis in Alzheimer's disease - A therapeutic opportunity?

Biochem Biophys Res Commun 2017 02 15;483(4):998-1004. Epub 2016 Sep 15.

Laboratory of Molecular Neurodegeneration, Department of Medical Physics, Peter the Great St. Petersburg Polytechnic University, St. Petersburg, Russian Federation; Department of Physiology, UT Southwestern Medical Center at Dallas, Dallas, TX, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbrc.2016.09.053DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5303663PMC
February 2017

Neurons from skin mimic brain holes.

Oncotarget 2017 Feb;8(6):8997-8998

Federal Clinical Research Center for Physical-Chemical Medicine FMBA, Moscow, Russia.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.18632/oncotarget.13709DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5354701PMC
February 2017

Misery loves company - shared features of neurodegenerative disorders.

Biochem Biophys Res Commun 2017 02;483(4):979-980

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbrc.2017.01.099DOI Listing
February 2017

The sigma-1 receptor mediates the beneficial effects of pridopidine in a mouse model of Huntington disease.

Neurobiol Dis 2017 01 3;97(Pt A):46-59. Epub 2016 Nov 3.

Department of Physiology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.nbd.2016.10.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5214572PMC
January 2017

In vivo analysis of cerebellar Purkinje cell activity in SCA2 transgenic mouse model.

J Neurophysiol 2016 06 16;115(6):2840-51. Epub 2016 Mar 16.

Laboratory of Molecular Neurodegeneration, Peter the Great St. Petersburg Polytechnic University, St. Petersburg, Russia; and Department of Physiology, University of Texas Southwestern Medical Center, Dallas, Texas

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1152/jn.00913.2015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4922606PMC
June 2016

The 2.2-Angstrom resolution crystal structure of the carboxy-terminal region of ataxin-3.

FEBS Open Bio 2016 03 18;6(3):168-78. Epub 2016 Feb 18.

Laboratory of Molecular Neurodegeneration St Petersburg State Polytechnical University Russia; Department of Physiology University of Texas Southwestern Medical Center Dallas TX USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/2211-5463.12029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4794786PMC
March 2016

Calcium signaling, excitability, and synaptic plasticity defects in a mouse model of Alzheimer's disease.

J Alzheimers Dis 2015 ;45(2):561-80

Department of Physiology, University of Texas Southwestern Medical Center, Dallas, TX, USA Laboratory of Molecular Neurodegeneration, St Petersburg State Polytechnical University, St Petersburg, Russia.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3233/JAD-142427DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4814213PMC
January 2016

Enhanced Store-Operated Calcium Entry Leads to Striatal Synaptic Loss in a Huntington's Disease Mouse Model.

J Neurosci 2016 Jan;36(1):125-41

Department of Physiology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, Laboratory of Molecular Neurodegeneration, St. Petersburg State Polytechnical University, St. Petersburg 195251, Russia, and

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1523/JNEUROSCI.1038-15.2016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4701955PMC
January 2016

Restoring calcium homeostasis to treat Alzheimer's disease: a future perspective.

Neurodegener Dis Manag 2015 Oct 19;5(5):395-8. Epub 2015 Oct 19.

Laboratory of Molecular Neurodegeneration, Department of Medical Physics, Peter the Great St Petersburg Polytechnic University, St Petersburg, Russian Federation.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2217/nmt.15.36DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5558533PMC
October 2015

Neuronal Store-Operated Calcium Entry and Mushroom Spine Loss in Amyloid Precursor Protein Knock-In Mouse Model of Alzheimer's Disease.

J Neurosci 2015 Sep;35(39):13275-86

Department of Physiology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, Laboratory of Molecular Neurodegeneration, St. Petersburg State Polytechnical University, St. Petersburg 195251, Russia,

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1523/JNEUROSCI.1034-15.2015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4588605PMC
September 2015

STIM2 protects hippocampal mushroom spines from amyloid synaptotoxicity.

Mol Neurodegener 2015 Aug 15;10:37. Epub 2015 Aug 15.

Laboratory of Molecular Neurodegeneration, Department of Medical Physics, Peter the Great St.Petersburg Polytechnic University, St. Petersburg, Russian Federation.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13024-015-0034-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4536802PMC
August 2015

An automated and quantitative method to evaluate progression of striatal pathology in Huntington's disease transgenic mice.

J Huntingtons Dis 2014 ;3(4):343-350

Department of Physiology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3233/JHD-140128DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4317287PMC
April 2015

Disturbed calcium signaling in spinocerebellar ataxias and Alzheimer's disease.

Semin Cell Dev Biol 2015 Apr 4;40:127-33. Epub 2015 Apr 4.

Laboratory of Molecular Neurodegeneration, St. Petersburg State Polytechnical University, St. Petersburg, Russia; Department of Physiology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.semcdb.2015.03.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4433580PMC
April 2015

Commentary on "Synaptic function is modulated by LRRK2 and glutamate release is increased in cortical neurons of G2019S LRRK2 knock-in mice".

Front Cell Neurosci 2014 28;8:351. Epub 2014 Oct 28.

Laboratory of Molecular Meurodegeneration, Department of Medical Physics, St. Petersburg State Polytechnical University St. Petersburg, Russia ; Department of Physiology, UT Southwestern Medical Center at Dallas Dallas, TX, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fncel.2014.00351DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4211405PMC
November 2014

Can the calcium hypothesis explain synaptic loss in Alzheimer's disease?

Neurodegener Dis 2014 24;13(2-3):139-41. Epub 2013 Sep 24.

Laboratory of Molecular Neurodegeneration, St. Petersburg State Polytechnical University, St. Petersburg, Russia.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000354778DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3946370PMC
September 2014

Intracellular calcium channels: inositol-1,4,5-trisphosphate receptors.

Eur J Pharmacol 2014 Sep 1;739:39-48. Epub 2013 Dec 1.

Laboratory of Molecular Neurodegeneration, Department of Medical Physics, St. Petersburg State Polytechnical University, 195251 St. Petersburg, Russia; Department of Physiology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ejphar.2013.10.074DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4040340PMC
September 2014

Simplified method to perform CLARITY imaging.

Mol Neurodegener 2014 May 26;9:19. Epub 2014 May 26.

Department of Medical Physics, St,Petersburg State Polytechnical University, St Petersburg 195251, Russia.

View Article

Download full-text PDF

Source
http://molecularneurodegeneration.biomedcentral.com/articles
Publisher Site
http://dx.doi.org/10.1186/1750-1326-9-19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4049387PMC
May 2014

Reduced synaptic STIM2 expression and impaired store-operated calcium entry cause destabilization of mature spines in mutant presenilin mice.

Neuron 2014 Apr;82(1):79-93

Department of Physiology, UT Southwestern Medical Center at Dallas, Dallas, TX 75390, USA; Laboratory of Molecular Neurodegeneration, Saint Petersburg State Polytechnical University, Saint Petersburg, 195251, Russia. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.neuron.2014.02.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4007018PMC
April 2014

Bilayer measurement of endoplasmic reticulum Ca2+ channels.

Cold Spring Harb Protoc 2013 Nov 1;2013(11). Epub 2013 Nov 1.

Department of Physiology, University of Texas Southwestern Medical Center, Dallas, Texas 75390;

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1101/pdb.top066225DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4317291PMC
November 2013

Preparation of microsomes to study Ca2+ channels.

Cold Spring Harb Protoc 2013 Nov 1;2013(11). Epub 2013 Nov 1.

Department of Physiology, University of Texas Southwestern Medical Center, Dallas, Texas 75390;

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1101/pdb.prot073098DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4996662PMC
November 2013

Reconstitution of endoplasmic reticulum InsP3 receptors into black lipid membranes.

Cold Spring Harb Protoc 2013 Nov 1;2013(11). Epub 2013 Nov 1.

Department of Physiology, University of Texas Southwestern Medical Center, Dallas, Texas 75390;

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1101/pdb.prot073106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5018385PMC
November 2013

Role of endoplasmic reticulum Ca2+ signaling in the pathogenesis of Alzheimer disease.

Front Mol Neurosci 2013 18;6:29. Epub 2013 Sep 18.

Laboratory of Molecular Neurodegeneration, Saint Petersburg State Polytechnical University Saint Petersburg, Russia.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fnmol.2013.00029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3776136PMC
September 2013

The synaptic maintenance problem: membrane recycling, Ca2+ homeostasis and late onset degeneration.

Mol Neurodegener 2013 Jul 8;8:23. Epub 2013 Jul 8.

Department of Physiology, UT Southwestern Medical Center, Dallas, TX 75390-9040, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/1750-1326-8-23DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3708831PMC
July 2013

Presenilins and calcium signaling-systems biology to the rescue.

Sci Signal 2013 Jul 9;6(283):pe24. Epub 2013 Jul 9.

Department of Physiology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1126/scisignal.2004296DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5018382PMC
July 2013

Aβ42-binding peptoids as amyloid aggregation inhibitors and detection ligands.

ACS Chem Neurosci 2013 Jun 7;4(6):952-62. Epub 2013 Mar 7.

Department of Physiology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/cn400011fDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3689191PMC
June 2013

Presenilins: a novel link between intracellular calcium signaling and lysosomal function?

J Cell Biol 2012 Jul;198(1):7-10

Department of Physiology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1083/jcb.201206003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3392935PMC
July 2012

The C terminus of Bax inhibitor-1 forms a Ca2+-permeable channel pore.

J Biol Chem 2012 Jan 28;287(4):2544-57. Epub 2011 Nov 28.

Department of Molecular Cell Biology, Laboratory of Molecular and Cellular Signaling, K.U. Leuven, B-3000 Leuven, Belgium.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M111.275354DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3268414PMC
January 2012

Dantrolene is neuroprotective in Huntington's disease transgenic mouse model.

Mol Neurodegener 2011 Nov 25;6:81. Epub 2011 Nov 25.

Department of Physiology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/1750-1326-6-81DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3235068PMC
November 2011

Presenilins function in ER calcium leak and Alzheimer's disease pathogenesis.

Cell Calcium 2011 Sep 12;50(3):303-9. Epub 2011 Jun 12.

Department of Physiology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390-9040, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ceca.2011.05.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3172403PMC
September 2011

Presenilins as endoplasmic reticulum calcium leak channels and Alzheimer's disease pathogenesis.

Sci China Life Sci 2011 Aug 24;54(8):744-51. Epub 2011 Jul 24.

Department of Physiology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390-9040, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11427-011-4201-yDOI Listing
August 2011

Role of inositol 1,4,5-trisphosphate receptors in pathogenesis of Huntington's disease and spinocerebellar ataxias.

Neurochem Res 2011 Jul 6;36(7):1186-97. Epub 2011 Jan 6.

Department of Physiology, ND12.200AA, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390-9040, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11064-010-0393-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3094593PMC
July 2011

Mutagenesis mapping of the presenilin 1 calcium leak conductance pore.

J Biol Chem 2011 Jun 29;286(25):22339-47. Epub 2011 Apr 29.

Department of Physiology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390-9040, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M111.243063DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3121381PMC
June 2011

Familial Alzheimer's disease mutations in presenilins: effects on endoplasmic reticulum calcium homeostasis and correlation with clinical phenotypes.

J Alzheimers Dis 2010 ;21(3):781-93

Department of Physiology, UT Southwestern Medical Center at Dallas, Dallas, Texas 75390-9040, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3233/JAD-2010-100159DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4996666PMC
January 2011

Homer regulation of native plasma membrane calcium channels in A431 cells.

Cell Calcium 2010 Oct;48(4):209-14

Institute of Cytology RAS, St Petersburg 194064, Russia. a

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ceca.2010.09.002DOI Listing
October 2010

The rise and fall of Dimebon.

Drug News Perspect 2010 Oct;23(8):518-23

Department of Physiology, University of Texas Southwestern Medical Center, Dallas, TX, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1358/dnp.2010.23.8.1500435DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3922928PMC
October 2010

Neuronal calcium signaling, mitochondrial dysfunction, and Alzheimer's disease.

J Alzheimers Dis 2010 ;20 Suppl 2:S487-98

Department of Physiology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3233/JAD-2010-100306DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4996661PMC
September 2010

Corticostriatal circuit dysfunction in Huntington's disease: intersection of glutamate, dopamine and calcium.

Future Neurol 2010 Sep;5(5):735-756

Department of Physiology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2217/fnl.10.41DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3184508PMC
September 2010

Role of presenilins in neuronal calcium homeostasis.

J Neurosci 2010 Jun;30(25):8566-80

Department of Physiology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1523/JNEUROSCI.1554-10.2010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2906098PMC
June 2010

Tetrabenazine is neuroprotective in Huntington's disease mice.

Mol Neurodegener 2010 Apr 26;5:18. Epub 2010 Apr 26.

Department of Physiology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/1750-1326-5-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2873255PMC
April 2010

The dysregulation of intracellular calcium in Alzheimer disease.

Cell Calcium 2010 Feb 18;47(2):183-9. Epub 2010 Jan 18.

Department of Physiology, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd., Dallas, TX 75390-9040, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ceca.2009.12.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2834825PMC
February 2010

Therapeutic prospects for spinocerebellar ataxia type 2 and 3.

Drugs Future 2009 Dec;34(12)

Department of Neurology, University Hospital Bonn, Bonn, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1358/dof.2009.034.12.1443434DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4443849PMC
December 2009

Secondary structure of Huntingtin amino-terminal region.

Structure 2009 Sep;17(9):1205-12

Department of Biochemistry, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.str.2009.08.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2863341PMC
September 2009

Deranged calcium signaling and neurodegeneration in spinocerebellar ataxia type 2.

J Neurosci 2009 Jul;29(29):9148-62

Department of Physiology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1523/JNEUROSCI.0660-09.2009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2749883PMC
July 2009

Ginsenosides protect striatal neurons in a cellular model of Huntington's disease.

J Neurosci Res 2009 Jun;87(8):1904-12

Department of Physiology, UT Southwestern Medical Center at Dallas, Dallas, Texas 75390, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jnr.22017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2792727PMC
June 2009

Allele-specific silencing of mutant huntingtin and ataxin-3 genes by targeting expanded CAG repeats in mRNAs.

Nat Biotechnol 2009 May 3;27(5):478-84. Epub 2009 May 3.

Department of Pharmacology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nbt.1539DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2765218PMC
May 2009

Calcium signaling and neurodegenerative diseases.

Trends Mol Med 2009 Mar 21;15(3):89-100. Epub 2009 Feb 21.

Department of Physiology, UT Southwestern Medical Center at Dallas, Dallas, TX 75390-9040, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.molmed.2009.01.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3226745PMC
March 2009

Amyloid goes global.

Sci Signal 2009 Mar 24;2(63):pe16. Epub 2009 Mar 24.

Department of Physiology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1126/scisignal.263pe16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4996660PMC
March 2009

Neuroprotective effects of inositol 1,4,5-trisphosphate receptor C-terminal fragment in a Huntington's disease mouse model.

J Neurosci 2009 Feb;29(5):1257-66

Department of Physiology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1523/JNEUROSCI.4411-08.2009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2768402PMC
February 2009

Evaluation of Dimebon in cellular model of Huntington's disease.

Mol Neurodegener 2008 Oct 21;3:15. Epub 2008 Oct 21.

Department of Physiology, UT Southwestern Medical Center at Dallas, TX 75390, USA.

View Article

Download full-text PDF

Source
http://link.springer.com/content/pdf/10.1186/1750-1326-3-15.
Web Search
http://www.molecularneurodegeneration.com/content/3/1/15
Publisher Site
http://dx.doi.org/10.1186/1750-1326-3-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2577671PMC
October 2008

Neuronal calcium mishandling and the pathogenesis of Alzheimer's disease.

Trends Neurosci 2008 Sep 31;31(9):454-63. Epub 2008 Jul 31.

Department of Physiology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.tins.2008.06.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2566585PMC
September 2008

Full length mutant huntingtin is required for altered Ca2+ signaling and apoptosis of striatal neurons in the YAC mouse model of Huntington's disease.

Neurobiol Dis 2008 Jul 16;31(1):80-8. Epub 2008 Apr 16.

Department of Physiology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.nbd.2008.03.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2528878PMC
July 2008

Small-molecule activation of neuronal cell fate.

Nat Chem Biol 2008 Jul 15;4(7):408-10. Epub 2008 Jun 15.

Department of Internal Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nchembio.95DOI Listing
July 2008

The inositol 1,4,5-trisphosphate receptors.

Cell Calcium 2005 Sep-Oct;38(3-4):261-72

University of Texas, Department of Physiology, UT Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd., Dallas, Texas 75390-9040, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ceca.2005.06.030DOI Listing
May 2008

Dopaminergic signaling and striatal neurodegeneration in Huntington's disease.

J Neurosci 2007 Jul;27(30):7899-910

Department of Physiology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1523/JNEUROSCI.1396-07.2007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3307545PMC
July 2007

Familial Alzheimer disease-linked mutations specifically disrupt Ca2+ leak function of presenilin 1.

J Clin Invest 2007 May 12;117(5):1230-9. Epub 2007 Apr 12.

Department of Physiology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1172/JCI30447DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1847535PMC
May 2007

Localization of L-type calcium channel Ca(V)1.3 in cat lumbar spinal cord--with emphasis on motoneurons.

Neurosci Lett 2006 Oct 1;407(1):42-7. Epub 2006 Sep 1.

Department of Medical Physiology, the Panum Institute, University of Copenhagen, Blegdamsvej 3, DK-2200 Copenhagen, Denmark.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.neulet.2006.07.073DOI Listing
October 2006

Evaluation of clinically relevant glutamate pathway inhibitors in in vitro model of Huntington's disease.

Neurosci Lett 2006 Oct 7;407(3):219-23. Epub 2006 Sep 7.

Department of Physiology, UT Southwestern Medical Center at Dallas, TX, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.neulet.2006.08.036DOI Listing
October 2006

Reelin modulates NMDA receptor activity in cortical neurons.

J Neurosci 2005 Sep;25(36):8209-16

Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1523/JNEUROSCI.1951-05.2005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6725528PMC
September 2005

Functional properties of endogenous receptor- and store-operated calcium influx channels in HEK293 cells.

J Biol Chem 2005 Apr 1;280(17):16790-7. Epub 2005 Mar 1.

Institute of Cytology RAS, 4 Tikhoretsky Avenue, St. Petersburg 194064, Russia.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M500192200DOI Listing
April 2005

Modulation of mammalian inositol 1,4,5-trisphosphate receptor isoforms by calcium: a role of calcium sensor region.

Biophys J 2005 Feb 5;88(2):1056-69. Epub 2004 Nov 5.

Department of Physiology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1529/biophysj.104.049601DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1305112PMC
February 2005

Functional characterization of mammalian inositol 1,4,5-trisphosphate receptor isoforms.

Biophys J 2005 Feb 8;88(2):1046-55. Epub 2004 Nov 8.

Department of Physiology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1529/biophysj.104.049593DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1305111PMC
February 2005

Association of CaV1.3 L-type calcium channels with Shank.

J Neurosci 2005 Feb;25(5):1037-49

Department of Physiology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1523/JNEUROSCI.4554-04.2005DOI Listing
February 2005

Disturbed Ca2+ signaling and apoptosis of medium spiny neurons in Huntington's disease.

Proc Natl Acad Sci U S A 2005 Feb 3;102(7):2602-7. Epub 2005 Feb 3.

Department of Physiology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.0409402102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC548984PMC
February 2005

HAP1 facilitates effects of mutant huntingtin on inositol 1,4,5-trisphosphate-induced Ca release in primary culture of striatal medium spiny neurons.

Eur J Neurosci 2004 Oct;20(7):1779-87

Department of Physiology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/j.1460-9568.2004.03633.xDOI Listing
October 2004

Functional properties of a pore mutant in the Drosophila melanogaster inositol 1,4,5-trisphosphate receptor.

FEBS Lett 2004 Sep;575(1-3):95-8

National Centre for Biological Sciences, Tata Institute of Fundamental Research, Gandhi Krishi Vigyan Kendra Campus, Bangalore 560 065, India.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.febslet.2004.08.042DOI Listing
September 2004