Ilse Rooman

Ilse Rooman

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Ilse Rooman

Ilse Rooman

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On-Label or Off-Label? Overcoming Regulatory and Financial Barriers to Bring Repurposed Medicines to Cancer Patients.

Front Pharmacol 2019 31;10:1664. Epub 2020 Jan 31.

Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, Leuven, Belgium.

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http://dx.doi.org/10.3389/fphar.2019.01664DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7006723PMC
January 2020

Adult human pancreatic acinar cells dedifferentiate into an embryonic progenitor-like state in 3D suspension culture.

Sci Rep 2019 03 11;9(1):4040. Epub 2019 Mar 11.

Cell Differentiation Laboratory, Vrije Universiteit Brussel, 1090, Brussels, Belgium.

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http://dx.doi.org/10.1038/s41598-019-40481-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6411888PMC
March 2019

Young GI angle: My biggest (career) mistake.

United European Gastroenterol J 2018 Oct 30;6(8):1278-1279. Epub 2018 Sep 30.

Oncology Research Centre, Vrije Universiteit Brussel, Brussels, Belgium.

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http://journals.sagepub.com/doi/10.1177/2050640618803045
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http://dx.doi.org/10.1177/2050640618803045DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6169041PMC
October 2018

Corrigendum: Whole-genome landscape of pancreatic neuroendocrine tumours.

Authors:
Aldo Scarpa David K Chang Katia Nones Vincenzo Corbo Ann-Marie Patch Peter Bailey Rita T Lawlor Amber L Johns David K Miller Andrea Mafficini Borislav Rusev Maria Scardoni Davide Antonello Stefano Barbi Katarzyna O Sikora Sara Cingarlini Caterina Vicentini Skye McKay Michael C J Quinn Timothy J C Bruxner Angelika N Christ Ivon Harliwong Senel Idrisoglu Suzanne McLean Craig Nourse Ehsan Nourbakhsh Peter J Wilson Matthew J Anderson J Lynn Fink Felicity Newell Nick Waddell Oliver Holmes Stephen H Kazakoff Conrad Leonard Scott Wood Qinying Xu Shivashankar Hiriyur Nagaraj Eliana Amato Irene Dalai Samantha Bersani Ivana Cataldo Angelo P Dei Tos Paola Capelli Maria Vittoria Davì Luca Landoni Anna Malpaga Marco Miotto Vicki L J Whitehall Barbara A Leggett Janelle L Harris Jonathan Harris Marc D Jones Jeremy Humphris Lorraine A Chantrill Venessa Chin Adnan M Nagrial Marina Pajic Christopher J Scarlett Andreia Pinho Ilse Rooman Christopher Toon Jianmin Wu Mark Pinese Mark Cowley Andrew Barbour Amanda Mawson Emily S Humphrey Emily K Colvin Angela Chou Jessica A Lovell Nigel B Jamieson Fraser Duthie Marie-Claude Gingras William E Fisher Rebecca A Dagg Loretta M S Lau Michael Lee Hilda A Pickett Roger R Reddel Jaswinder S Samra James G Kench Neil D Merrett Krishna Epari Nam Q Nguyen Nikolajs Zeps Massimo Falconi Michele Simbolo Giovanni Butturini George Van Buren Stefano Partelli Matteo Fassan Kum Kum Khanna Anthony J Gill David A Wheeler Richard A Gibbs Elizabeth A Musgrove Claudio Bassi Giampaolo Tortora Paolo Pederzoli John V Pearson Nicola Waddell Andrew V Biankin Sean M Grimmond

Nature 2017 10 27;550(7677):548. Epub 2017 Sep 27.

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http://dx.doi.org/10.1038/nature24026DOI Listing
October 2017

Whole-genome landscape of pancreatic neuroendocrine tumours.

Authors:
Aldo Scarpa David K Chang Katia Nones Vincenzo Corbo Ann-Marie Patch Peter Bailey Rita T Lawlor Amber L Johns David K Miller Andrea Mafficini Borislav Rusev Maria Scardoni Davide Antonello Stefano Barbi Katarzyna O Sikora Sara Cingarlini Caterina Vicentini Skye McKay Michael C J Quinn Timothy J C Bruxner Angelika N Christ Ivon Harliwong Senel Idrisoglu Suzanne McLean Craig Nourse Ehsan Nourbakhsh Peter J Wilson Matthew J Anderson J Lynn Fink Felicity Newell Nick Waddell Oliver Holmes Stephen H Kazakoff Conrad Leonard Scott Wood Qinying Xu Shivashankar Hiriyur Nagaraj Eliana Amato Irene Dalai Samantha Bersani Ivana Cataldo Angelo P Dei Tos Paola Capelli Maria Vittoria Davì Luca Landoni Anna Malpaga Marco Miotto Vicki L J Whitehall Barbara A Leggett Janelle L Harris Jonathan Harris Marc D Jones Jeremy Humphris Lorraine A Chantrill Venessa Chin Adnan M Nagrial Marina Pajic Christopher J Scarlett Andreia Pinho Ilse Rooman Christopher Toon Jianmin Wu Mark Pinese Mark Cowley Andrew Barbour Amanda Mawson Emily S Humphrey Emily K Colvin Angela Chou Jessica A Lovell Nigel B Jamieson Fraser Duthie Marie-Claude Gingras William E Fisher Rebecca A Dagg Loretta M S Lau Michael Lee Hilda A Pickett Roger R Reddel Jaswinder S Samra James G Kench Neil D Merrett Krishna Epari Nam Q Nguyen Nikolajs Zeps Massimo Falconi Michele Simbolo Giovanni Butturini George Van Buren Stefano Partelli Matteo Fassan Kum Kum Khanna Anthony J Gill David A Wheeler Richard A Gibbs Elizabeth A Musgrove Claudio Bassi Giampaolo Tortora Paolo Pederzoli John V Pearson Nicola Waddell Andrew V Biankin Sean M Grimmond

Nature 2017 03 15;543(7643):65-71. Epub 2017 Feb 15.

University of Melbourne Centre for Cancer Research, University of Melbourne, Melbourne, 3010, Victoria, Australia.

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http://dx.doi.org/10.1038/nature21063DOI Listing
March 2017

Hypermutation In Pancreatic Cancer.

Gastroenterology 2017 01 15;152(1):68-74.e2. Epub 2016 Nov 15.

Wolfson Wohl Cancer Research Centre, Institute of Cancer Sciences, University of Glasgow, Glasgow, Scotland, United Kingdom; Department of Surgery, Bankstown Hospital, Bankstown, Sydney, New South Wales, Australia; South Western Sydney Clinical School, Faculty of Medicine, University of New South Wales Australia, Liverpool, New South Wales, Australia; West of Scotland Pancreatic Unit, Glasgow Royal Infirmary, Glasgow, United Kingdom. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00165085163518
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http://dx.doi.org/10.1053/j.gastro.2016.09.060DOI Listing
January 2017

Repurposing Drugs in Oncology (ReDO)-Propranolol as an anti-cancer agent.

Ecancermedicalscience 2016 12;10:680. Epub 2016 Oct 12.

GlobalCures, Inc, Newton MA 02459, USA; Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA.

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http://dx.doi.org/10.3332/ecancer.2016.680DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5102691PMC
October 2016

Emerging Drug Target In Pancreatic Cancer: Placing Sirtuin 1 on the Canvas.

Curr Cancer Drug Targets 2015 ;15(6):463-8

The Garvan Institute of Medical Research, Sydney, Australia.

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http://dx.doi.org/10.2174/1568009615666150512102957DOI Listing
May 2016

Pancreas-Specific Sirt1-Deficiency in Mice Compromises Beta-Cell Function without Development of Hyperglycemia.

PLoS One 2015 5;10(6):e0128012. Epub 2015 Jun 5.

Cancer Division, Garvan Institute of Medical Research, The Kinghorn Cancer Centre, Darlinghurst NSW, Australia; St. Vincent's Clinical School, Faculty of Medicine, UNSW Australia, Randwick NSW, Australia; Diabetes Research Center, Vrije Universiteit Brussel, Brussels, Belgium.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0128012PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4457418PMC
March 2016

Genomic analyses identify molecular subtypes of pancreatic cancer.

Authors:
Peter Bailey David K Chang Katia Nones Amber L Johns Ann-Marie Patch Marie-Claude Gingras David K Miller Angelika N Christ Tim J C Bruxner Michael C Quinn Craig Nourse L Charles Murtaugh Ivon Harliwong Senel Idrisoglu Suzanne Manning Ehsan Nourbakhsh Shivangi Wani Lynn Fink Oliver Holmes Venessa Chin Matthew J Anderson Stephen Kazakoff Conrad Leonard Felicity Newell Nick Waddell Scott Wood Qinying Xu Peter J Wilson Nicole Cloonan Karin S Kassahn Darrin Taylor Kelly Quek Alan Robertson Lorena Pantano Laura Mincarelli Luis N Sanchez Lisa Evers Jianmin Wu Mark Pinese Mark J Cowley Marc D Jones Emily K Colvin Adnan M Nagrial Emily S Humphrey Lorraine A Chantrill Amanda Mawson Jeremy Humphris Angela Chou Marina Pajic Christopher J Scarlett Andreia V Pinho Marc Giry-Laterriere Ilse Rooman Jaswinder S Samra James G Kench Jessica A Lovell Neil D Merrett Christopher W Toon Krishna Epari Nam Q Nguyen Andrew Barbour Nikolajs Zeps Kim Moran-Jones Nigel B Jamieson Janet S Graham Fraser Duthie Karin Oien Jane Hair Robert Grützmann Anirban Maitra Christine A Iacobuzio-Donahue Christopher L Wolfgang Richard A Morgan Rita T Lawlor Vincenzo Corbo Claudio Bassi Borislav Rusev Paola Capelli Roberto Salvia Giampaolo Tortora Debabrata Mukhopadhyay Gloria M Petersen Donna M Munzy William E Fisher Saadia A Karim James R Eshleman Ralph H Hruban Christian Pilarsky Jennifer P Morton Owen J Sansom Aldo Scarpa Elizabeth A Musgrove Ulla-Maja Hagbo Bailey Oliver Hofmann Robert L Sutherland David A Wheeler Anthony J Gill Richard A Gibbs John V Pearson Nicola Waddell Andrew V Biankin Sean M Grimmond

Nature 2016 Mar 24;531(7592):47-52. Epub 2016 Feb 24.

Queensland Centre for Medical Genomics, Institute for Molecular Bioscience, The University of Queensland, St Lucia, Brisbane, Queensland 4072, Australia.

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http://dx.doi.org/10.1038/nature16965DOI Listing
March 2016

Whole genomes redefine the mutational landscape of pancreatic cancer.

Nature 2015 Feb;518(7540):495-501

1] Queensland Centre for Medical Genomics, Institute for Molecular Bioscience, The University of Queensland, St Lucia, Brisbane, Queensland 4072, Australia [2] Wolfson Wohl Cancer Research Centre, Institute of Cancer Sciences, University of Glasgow, Garscube Estate, Switchback Road, Bearsden, Glasgow G61 1BD, UK.

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http://dx.doi.org/10.1038/nature14169DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4523082PMC
February 2015

Sirtainties in pancreatic cancer?

Authors:
Ilse Rooman

Oncoscience 2014 3;1(3):183-4. Epub 2014 Apr 3.

The Garvan Institute of Medical Research / The Kinghorn Cancer Centre, Darlinghurst, Australia.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4278293PMC
http://dx.doi.org/10.18632/oncoscience.28DOI Listing
January 2015

Clinical and molecular characterization of HER2 amplified-pancreatic cancer.

Genome Med 2013 31;5(8):78. Epub 2013 Aug 31.

Kinghorn Cancer Centre and Garvan Institute of Medical Research, Darlinghurst, Sydney, Australia ; Wolfson Wohl Cancer Research Centre, Institute of Cancer Sciences, University of Glasgow, Glasgow, UK ; West of Scotland Pancreatic Unit, Glasgow Royal Infirmary, Glasgow, UK.

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http://dx.doi.org/10.1186/gm482DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3978667PMC
May 2014

Amino acid transporters expression in acinar cells is changed during acute pancreatitis.

Pancreatology 2013 Sep-Oct;13(5):475-85. Epub 2013 Jun 27.

Cancer Research Program, The Kinghorn Cancer Centre, Garvan Institute of Medical Research, Darlinghurst-Sydney, NSW, Australia; St Vincent's Clinical School, University New South Wales, Australia; Cell Differentiation Unit, Diabetes Research Center, Vrije Universiteit Brussel, Brussels, Belgium.

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http://dx.doi.org/10.1016/j.pan.2013.06.006DOI Listing
May 2014

Chronic pancreatitis: a path to pancreatic cancer.

Cancer Lett 2014 Apr 24;345(2):203-9. Epub 2013 Aug 24.

Cancer Research Program, The Kinghorn Cancer Centre, Garvan Institute of Medical Research, Sydney, Australia; St. Vincent's Clinical School, University of New South Wales, Sydney, Australia; Diabetes Research Center, Vrije Universiteit Brussel, Brussels, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.canlet.2013.08.015DOI Listing
April 2014

Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes.

Authors:
Andrew V Biankin Nicola Waddell Karin S Kassahn Marie-Claude Gingras Lakshmi B Muthuswamy Amber L Johns David K Miller Peter J Wilson Ann-Marie Patch Jianmin Wu David K Chang Mark J Cowley Brooke B Gardiner Sarah Song Ivon Harliwong Senel Idrisoglu Craig Nourse Ehsan Nourbakhsh Suzanne Manning Shivangi Wani Milena Gongora Marina Pajic Christopher J Scarlett Anthony J Gill Andreia V Pinho Ilse Rooman Matthew Anderson Oliver Holmes Conrad Leonard Darrin Taylor Scott Wood Qinying Xu Katia Nones J Lynn Fink Angelika Christ Tim Bruxner Nicole Cloonan Gabriel Kolle Felicity Newell Mark Pinese R Scott Mead Jeremy L Humphris Warren Kaplan Marc D Jones Emily K Colvin Adnan M Nagrial Emily S Humphrey Angela Chou Venessa T Chin Lorraine A Chantrill Amanda Mawson Jaswinder S Samra James G Kench Jessica A Lovell Roger J Daly Neil D Merrett Christopher Toon Krishna Epari Nam Q Nguyen Andrew Barbour Nikolajs Zeps Nipun Kakkar Fengmei Zhao Yuan Qing Wu Min Wang Donna M Muzny William E Fisher F Charles Brunicardi Sally E Hodges Jeffrey G Reid Jennifer Drummond Kyle Chang Yi Han Lora R Lewis Huyen Dinh Christian J Buhay Timothy Beck Lee Timms Michelle Sam Kimberly Begley Andrew Brown Deepa Pai Ami Panchal Nicholas Buchner Richard De Borja Robert E Denroche Christina K Yung Stefano Serra Nicole Onetto Debabrata Mukhopadhyay Ming-Sound Tsao Patricia A Shaw Gloria M Petersen Steven Gallinger Ralph H Hruban Anirban Maitra Christine A Iacobuzio-Donahue Richard D Schulick Christopher L Wolfgang Richard A Morgan Rita T Lawlor Paola Capelli Vincenzo Corbo Maria Scardoni Giampaolo Tortora Margaret A Tempero Karen M Mann Nancy A Jenkins Pedro A Perez-Mancera David J Adams David A Largaespada Lodewyk F A Wessels Alistair G Rust Lincoln D Stein David A Tuveson Neal G Copeland Elizabeth A Musgrove Aldo Scarpa James R Eshleman Thomas J Hudson Robert L Sutherland David A Wheeler John V Pearson John D McPherson Richard A Gibbs Sean M Grimmond

Nature 2012 Nov 24;491(7424):399-405. Epub 2012 Oct 24.

The Kinghorn Cancer Centre, 370 Victoria Street, Darlinghurst, Sydney, New South Wales 2010, Australia.

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http://dx.doi.org/10.1038/nature11547DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3530898PMC
November 2012

Pancreatic ductal adenocarcinoma and acinar cells: a matter of differentiation and development?

Gut 2012 Mar 5;61(3):449-58. Epub 2011 Jul 5.

Cancer Research Program, Garvan Institute of Medical Research, Darlinghurst-Sydney, NSW, Australia.

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http://gut.bmj.com/lookup/doi/10.1136/gut.2010.235804
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http://dx.doi.org/10.1136/gut.2010.235804DOI Listing
March 2012

Lineage tracing evidence for transdifferentiation of acinar to duct cells and plasticity of human pancreas.

Gastroenterology 2011 Aug 4;141(2):731-41, 741.e1-4. Epub 2011 May 4.

Cell Differentiation Laboratory, Diabetes Research Center, Free University of Brussels, Brussels, Belgium.

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http://dx.doi.org/10.1053/j.gastro.2011.04.050DOI Listing
August 2011

Adult pancreatic acinar cells dedifferentiate to an embryonic progenitor phenotype with concomitant activation of a senescence programme that is present in chronic pancreatitis.

Gut 2011 Jul 30;60(7):958-66. Epub 2010 Dec 30.

Programa de Patología Molecular, Centro Nacional de Investigaciones Oncológicas, Melchor Fernández Almagro 3, 28029-Madrid, Spain.

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http://dx.doi.org/10.1136/gut.2010.225920DOI Listing
July 2011

p53-dependent regulation of growth, epithelial-mesenchymal transition and stemness in normal pancreatic epithelial cells.

Cell Cycle 2011 Apr 15;10(8):1312-21. Epub 2011 Apr 15.

Programa de Patología Molecular, Centro Nacional de Investigaciones Oncológicas, Madrid, Spain.

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http://dx.doi.org/10.4161/cc.10.8.15363DOI Listing
April 2011

Notch signaling as gatekeeper of rat acinar-to-beta-cell conversion in vitro.

Gastroenterology 2009 May 27;136(5):1750-60.e13. Epub 2009 Jan 27.

Diabetes Research Center, Vrije Universiteit Brussel, Brussels, Belgium.

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http://dx.doi.org/10.1053/j.gastro.2009.01.047DOI Listing
May 2009

p/CAF modulates the activity of the transcription factor p48/Ptf1a involved in pancreatic acinar differentiation.

Biochem J 2009 Mar;418(2):463-73

Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra, Doctor Aiguader 88, 08003 Barcelona, Spain.

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http://dx.doi.org/10.1042/BJ20080293DOI Listing
March 2009

Expression of the Notch signaling pathway and effect on exocrine cell proliferation in adult rat pancreas.

Am J Pathol 2006 Oct;169(4):1206-14

Cell Differentiation Unit-Diabetes Research Center, Vrije Universiteit Brussel, Laarbeeklaan 103, B-1090 Brussels, Belgium.

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http://linkinghub.elsevier.com/retrieve/pii/S000294401062593
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1698841PMC
http://dx.doi.org/10.2353/ajpath.2006.050926DOI Listing
October 2006

Regulation of pancreatic beta-cell mass.

Physiol Rev 2005 Oct;85(4):1255-70

Cell Differentiation Unit, Vrije Universiteit Brussel/Free University of Brussels, Laarbeeklaan 103, B-1090 Brussels, Belgium.

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http://dx.doi.org/10.1152/physrev.00025.2004DOI Listing
October 2005

Plasticity in the adult rat pancreas: transdifferentiation of exocrine to hepatocyte-like cells in primary culture.

Hepatology 2004 Jun;39(6):1499-507

Cell Differentiation Unit, Diabetes Research Center, Vrije Universiteit Brussel, Brussels, Belgium.

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http://doi.wiley.com/10.1002/hep.20213
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http://dx.doi.org/10.1002/hep.20213DOI Listing
June 2004

Exocrine cell transdifferentiation in dexamethasone-treated rat pancreas.

Virchows Arch 2004 Jan 25;444(1):61-5. Epub 2003 Nov 25.

Cell Differentiation Unit, Diabetes Research Center, Vrije Universiteit Brussel, Laarbeeklaan 103, 1090 Brussels, Belgium.

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http://link.springer.com/10.1007/s00428-003-0930-z
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http://dx.doi.org/10.1007/s00428-003-0930-zDOI Listing
January 2004

Nestin expression in pancreatic stellate cells and angiogenic endothelial cells.

Histochem Cell Biol 2002 Jun 14;117(6):535-40. Epub 2002 May 14.

Cell Differentiation Unit, Diabetes Research Center, Free University of Brussels (VUB), Laarbeeklaan 103, Belgium.

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http://dx.doi.org/10.1007/s00418-002-0412-4DOI Listing
June 2002

Gastrin stimulates beta-cell neogenesis and increases islet mass from transdifferentiated but not from normal exocrine pancreas tissue.

Diabetes 2002 Mar;51(3):686-90

Cell Differentiation Group, Diabetes Research Center, Free University of Brussels (VUB), Brussels, Belgium.

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http://dx.doi.org/10.2337/diabetes.51.3.686DOI Listing
March 2002