Publications by authors named "Ilsa M Coleman"

39 Publications

Cabozantinib can block growth of neuroendocrine prostate cancer patient-derived xenografts by disrupting tumor vasculature.

Authors:
Mark P Labrecque Lisha G Brown Ilsa M Coleman Holly M Nguyen Daniel W Lin Eva Corey Peter S Nelson Colm Morrissey

PLoS One 2021 20;16(1):e0245602. Epub 2021 Jan 20.

Department of Urology, University of Washington School of Medicine, Seattle, Washington, United States of America.

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January 2021

Imaging Fibroblast Activation Protein Alpha Improves Diagnosis of Metastatic Prostate Cancer with Positron Emission Tomography.

Authors:
Hallie M Hintz Joseph P Gallant Donald J Vander Griend Ilsa M Coleman Peter S Nelson Aaron M LeBeau

Clin Cancer Res 2020 Sep 7;26(18):4882-4891. Epub 2020 Jul 7.

Department of Pharmacology, University of Minnesota Medical School, Minneapolis, Minnesota.

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September 2020

Alternative splicing of LSD1+8a in neuroendocrine prostate cancer is mediated by SRRM4.

Authors:
Daniel J Coleman David A Sampson Archana Sehrawat Anbarasu Kumaraswamy Duanchen Sun Yuzhuo Wang Jacob Schwartzman Joshua Urrutia Ahn R Lee Ilsa M Coleman Peter S Nelson Xuesen Dong Colm Morrissey Eva Corey Zheng Xia Joel A Yates Joshi J Alumkal

Neoplasia 2020 06 11;22(6):253-262. Epub 2020 May 11.

Knight Cancer Institute, Oregon Health & Science University, Portland, OR, USA; Department of Internal Medicine, Division of Hematology and Oncology, University of Michigan, Ann Arbor, MI, USA; Rogel Cancer Center, University of Michigan, Ann Arbor, MI, USA. Electronic address:

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June 2020

A comparison of prostate cancer cell transcriptomes in 2D monoculture vs 3D xenografts identify consistent gene expression alterations associated with tumor microenvironments.

Authors:
Lauren Brady Rui M Gil da Costa Ilsa M Coleman Clinton K Matson Michael C Risk Roger T Coleman Peter S Nelson

Prostate 2020 05 18;80(6):491-499. Epub 2020 Feb 18.

Divisions of Human Biology and Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, Washington.

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May 2020

Differential Expression of Glucose Transporters and Hexokinases in Prostate Cancer with a Neuroendocrine Gene Signature: A Mechanistic Perspective for F-FDG Imaging of PSMA-Suppressed Tumors.

Authors:
Martin K Bakht Jessica M Lovnicki Janice Tubman Keith F Stringer Jonathan Chiaramonte Michael R Reynolds Iulian Derecichei Rosa-Maria Ferraiuolo Bre-Anne Fifield Dorota Lubanska So Won Oh Gi Jeong Cheon Cheol Kwak Chang Wook Jeong Keon Wook Kang John F Trant Colm Morrissey Ilsa M Coleman Yuzhuo Wang Hojjat Ahmadzadehfar Xuesen Dong Lisa A Porter

J Nucl Med 2020 06 5;61(6):904-910. Epub 2019 Dec 5.

Department of Biomedical Sciences, University of Windsor, Windsor, Ontario, Canada

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June 2020

Exploitation of CD133 for the Targeted Imaging of Lethal Prostate Cancer.

Authors:
Paige M Glumac Joseph P Gallant Mariya Shapovalova Yingming Li Paari Murugan Shilpa Gupta Ilsa M Coleman Peter S Nelson Scott M Dehm Aaron M LeBeau

Clin Cancer Res 2020 03 15;26(5):1054-1064. Epub 2019 Nov 15.

Department of Pharmacology, University of Minnesota Medical School, Minneapolis, Minnesota.

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March 2020

PEG10 Promoter-Driven Expression of Reporter Genes Enables Molecular Imaging of Lethal Prostate Cancer.

Authors:
Mariya Shapovalova John K Lee Yingming Li Donald J Vander Griend Ilsa M Coleman Peter S Nelson Scott M Dehm Aaron M LeBeau

Cancer Res 2019 11 17;79(21):5668-5680. Epub 2019 Sep 17.

Department of Pharmacology, University of Minnesota Medical School, Minneapolis, Minnesota.

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November 2019

The androgen receptor regulates a druggable translational regulon in advanced prostate cancer.

Authors:
Yuzhen Liu Jessie L Horn Kalyan Banda Asha Z Goodman Yiting Lim Sujata Jana Sonali Arora Alexandre A Germanos Lexiaochuan Wen William R Hardin Yu C Yang Ilsa M Coleman Robin G Tharakan Elise Y Cai Takuma Uo Smitha P S Pillai Eva Corey Colm Morrissey Yu Chen Brett S Carver Stephen R Plymate Slobodan Beronja Peter S Nelson Andrew C Hsieh

Sci Transl Med 2019 07;11(503)

Divisions of Human Biology and Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.

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July 2019

Molecular profiling stratifies diverse phenotypes of treatment-refractory metastatic castration-resistant prostate cancer.

Authors:
Mark P Labrecque Ilsa M Coleman Lisha G Brown Lawrence D True Lori Kollath Bryce Lakely Holly M Nguyen Yu C Yang Rui M Gil da Costa Arja Kaipainen Roger Coleman Celestia S Higano Evan Y Yu Heather H Cheng Elahe A Mostaghel Bruce Montgomery Michael T Schweizer Andrew C Hsieh Daniel W Lin Eva Corey Peter S Nelson Colm Morrissey

J Clin Invest 2019 07 30;129(10):4492-4505. Epub 2019 Jul 30.

Department of Urology, University of Washington, Seattle, Washington, USA.

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July 2019

Durable Response of Enzalutamide-resistant Prostate Cancer to Supraphysiological Testosterone Is Associated with a Multifaceted Growth Suppression and Impaired DNA Damage Response Transcriptomic Program in Patient-derived Xenografts.

Authors:
Hung-Ming Lam Holly M Nguyen Mark P Labrecque Lisha G Brown Ilsa M Coleman Roman Gulati Bryce Lakely Daniel Sondheim Payel Chatterjee Brett T Marck Alvin M Matsumoto Elahe A Mostaghel Michael T Schweizer Peter S Nelson Eva Corey

Eur Urol 2020 02 19;77(2):144-155. Epub 2019 Jun 19.

Department of Urology, University of Washington School of Medicine, Seattle, WA, USA. Electronic address:

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February 2020

Targeting the perivascular niche sensitizes disseminated tumour cells to chemotherapy.

Authors:
Patrick Carlson Arko Dasgupta Candice A Grzelak Jeanna Kim Alexander Barrett Ilsa M Coleman Ryann E Shor Erica T Goddard Jinxiang Dai Emma M Schweitzer Andrea R Lim Sarah B Crist David A Cheresh Peter S Nelson Kirk C Hansen Cyrus M Ghajar

Nat Cell Biol 2019 02 21;21(2):238-250. Epub 2019 Jan 21.

Public Health Sciences Division/Translational Research Program, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.

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February 2019

The Aged Microenvironment Influences the Tumorigenic Potential of Malignant Prostate Epithelial Cells.

Authors:
Daniella Bianchi-Frias Mamatha Damodarasamy Susana A Hernandez Rui M Gil da Costa Funda Vakar-Lopez Ilsa M Coleman May J Reed Peter S Nelson

Mol Cancer Res 2019 01 17;17(1):321-331. Epub 2018 Sep 17.

Divisions of Human Biology and Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, Washington.

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January 2019

A Novel Flavonoid Composition Targets Androgen Receptor Signaling and Inhibits Prostate Cancer Growth in Preclinical Models.

Authors:
Kenza Mamouni Shumin Zhang Xin Li Yanhua Chen Yang Yang Jaeah Kim Michael G Bartlett Ilsa M Coleman Peter S Nelson Omer Kucuk Daqing Wu

Neoplasia 2018 08 4;20(8):789-799. Epub 2018 Jul 4.

Molecular Oncology and Biomarkers Program, Georgia Cancer Center; Department of Biochemistry and Molecular Biology, Medical College of Georgia, Augusta University, Augusta, GA, USA; Department of Urology and Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA, USA; MetCure Therapeutics LLC, Atlanta, GA, USA. Electronic address:

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August 2018

Androgen Receptor Pathway-Independent Prostate Cancer Is Sustained through FGF Signaling.

Authors:
Eric G Bluemn Ilsa M Coleman Jared M Lucas Roger T Coleman Susana Hernandez-Lopez Robin Tharakan Daniella Bianchi-Frias Ruth F Dumpit Arja Kaipainen Alexandra N Corella Yu Chi Yang Michael D Nyquist Elahe Mostaghel Andrew C Hsieh Xiaotun Zhang Eva Corey Lisha G Brown Holly M Nguyen Kenneth Pienta Michael Ittmann Michael Schweizer Lawrence D True David Wise Paul S Rennie Robert L Vessella Colm Morrissey Peter S Nelson

Cancer Cell 2017 10;32(4):474-489.e6

Department of Medicine, University of Washington, Seattle, WA, USA; Divisions of Human Biology and Clinical Research, Fred Hutchinson Cancer Research Center, Mailstop D4-100, 1100 Fairview Avenue N, Seattle, WA 98109-1024, USA; Department of Urology, University of Washington, 1959 NE Pacific Street, Seattle, WA 98195, USA; Department of Pathology, University of Washington, Seattle, WA, USA. Electronic address:

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October 2017

Androgen Receptor Deregulation Drives Bromodomain-Mediated Chromatin Alterations in Prostate Cancer.

Authors:
Alfonso Urbanucci Stefan J Barfeld Ville Kytölä Harri M Itkonen Ilsa M Coleman Daniel Vodák Liisa Sjöblom Xia Sheng Teemu Tolonen Sarah Minner Christoph Burdelski Kati K Kivinummi Annika Kohvakka Steven Kregel Mandeep Takhar Mohammed Alshalalfa Elai Davicioni Nicholas Erho Paul Lloyd R Jeffrey Karnes Ashley E Ross Edward M Schaeffer Donald J Vander Griend Stefan Knapp Eva Corey Felix Y Feng Peter S Nelson Fahri Saatcioglu Karen E Knudsen Teuvo L J Tammela Guido Sauter Thorsten Schlomm Matti Nykter Tapio Visakorpi Ian G Mills

Cell Rep 2017 06;19(10):2045-2059

Centre for Molecular Medicine Norway, Nordic European Molecular Biology Laboratory Partnership, Forskningsparken, University of Oslo, 21 0349 Oslo, Norway; Department of Molecular Oncology, Institute for Cancer Research, Oslo University Hospital, 0424 Oslo, Norway; PCUK Movember Centre of Excellence, CCRCB, Queen's University, Belfast BT7 1NN, Northern Ireland, UK. Electronic address:

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June 2017

LuCaP Prostate Cancer Patient-Derived Xenografts Reflect the Molecular Heterogeneity of Advanced Disease an--d Serve as Models for Evaluating Cancer Therapeutics.

Authors:
Holly M Nguyen Robert L Vessella Colm Morrissey Lisha G Brown Ilsa M Coleman Celestia S Higano Elahe A Mostaghel Xiaotun Zhang Lawrence D True Hung-Ming Lam Martine Roudier Paul H Lange Peter S Nelson Eva Corey

Prostate 2017 May 3;77(6):654-671. Epub 2017 Feb 3.

Department of Urology, University of Washington, Seattle, Washington.

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May 2017

Cells Comprising the Prostate Cancer Microenvironment Lack Recurrent Clonal Somatic Genomic Aberrations.

Authors:
Daniella Bianchi-Frias Ryan Basom Jeffrey J Delrow Ilsa M Coleman Olga Dakhova Xiaoyu Qu Min Fang Omar E Franco Nolan G Ericson Jason H Bielas Simon W Hayward Lawrence True Colm Morrissey Lisha Brown Neil A Bhowmick David Rowley Michael Ittmann Peter S Nelson

Mol Cancer Res 2016 Apr 11;14(4):374-84. Epub 2016 Jan 11.

Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington. Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington. Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, Washington. Department of Pathology, University of Washington, Seattle, Washington. Department of Urology, University of Washington, Seattle, Washington. Department of Medicine, University of Washington, Seattle, Washington.

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April 2016

SRRM4 Expression and the Loss of REST Activity May Promote the Emergence of the Neuroendocrine Phenotype in Castration-Resistant Prostate Cancer.

Authors:
Xiaotun Zhang Ilsa M Coleman Lisha G Brown Lawrence D True Lori Kollath Jared M Lucas Hung-Ming Lam Ruth Dumpit Eva Corey Lisly Chéry Bryce Lakely Celestia S Higano Bruce Montgomery Martine Roudier Paul H Lange Peter S Nelson Robert L Vessella Colm Morrissey

Clin Cancer Res 2015 Oct 12;21(20):4698-708. Epub 2015 Jun 12.

Department of Urology, University of Washington, Seattle, Washington.

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October 2015

Prostate cancer derived prostatic acid phosphatase promotes an osteoblastic response in the bone microenvironment.

Authors:
Sandy R Larson Jessica Chin Xiaotun Zhang Lisha G Brown Ilsa M Coleman Bryce Lakely Martin Tenniswood Eva Corey Peter S Nelson Robert L Vessella Colm Morrissey

Clin Exp Metastasis 2014 Feb 17;31(2):247-56. Epub 2013 Nov 17.

Genitourinary Cancer Research Laboratory, Department of Urology, University of Washington, Box 356510, Seattle, WA, 98195, USA.

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February 2014

VEGF/neuropilin-2 regulation of Bmi-1 and consequent repression of IGF-IR define a novel mechanism of aggressive prostate cancer.

Authors:
Hira Lal Goel Cheng Chang Bryan Pursell Irwin Leav Stephen Lyle Hualin Simon Xi Chung-Cheng Hsieh Helty Adisetiyo Pradip Roy-Burman Ilsa M Coleman Peter S Nelson Robert L Vessella Roger J Davis Stephen R Plymate Arthur M Mercurio

Cancer Discov 2012 Oct 9;2(10):906-21. Epub 2012 Jul 9.

Department of Cancer Biology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA.

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October 2012

Metastatic progression of prostate cancer and e-cadherin regulation by zeb1 and SRC family kinases.

Authors:
Aaron P Putzke Aviva P Ventura Alexander M Bailey Canan Akture John Opoku-Ansah Müge Celiktaş Michael S Hwang Douglas S Darling Ilsa M Coleman Peter S Nelson Holly M Nguyen Eva Corey Muneesh Tewari Colm Morrissey Robert L Vessella Beatrice S Knudsen

Am J Pathol 2011 Jul 4;179(1):400-10. Epub 2011 May 4.

Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington; Department of Biology, Hope College, Holland, Michigan.

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July 2011

The effects of aging on the molecular and cellular composition of the prostate microenvironment.

Authors:
Daniella Bianchi-Frias Funda Vakar-Lopez Ilsa M Coleman Stephen R Plymate May J Reed Peter S Nelson

PLoS One 2010 Sep 1;5(9). Epub 2010 Sep 1.

Divisions of Human Biology and Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America.

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September 2010

Castration resistance in human prostate cancer is conferred by a frequently occurring androgen receptor splice variant.

Authors:
Shihua Sun Cynthia C T Sprenger Robert L Vessella Kathleen Haugk Kathryn Soriano Elahe A Mostaghel Stephanie T Page Ilsa M Coleman Holly M Nguyen Huiying Sun Peter S Nelson Stephen R Plymate

J Clin Invest 2010 Aug 19;120(8):2715-30. Epub 2010 Jul 19.

Department of Medicine, University of Washington School of Medicine, Seattle, Washington 98104, USA.

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August 2010

Variability in the androgen response of prostate epithelium to 5alpha-reductase inhibition: implications for prostate cancer chemoprevention.

Authors:
Elahe A Mostaghel Linda Geng Ilona Holcomb Ilsa M Coleman Jared Lucas Lawrence D True Peter S Nelson

Cancer Res 2010 Feb 2;70(4):1286-95. Epub 2010 Feb 2.

Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, D4-100, Seattle, WA 91809, USA.

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February 2010

The expression of osteoclastogenesis-associated factors and osteoblast response to osteolytic prostate cancer cells.

Authors:
Colm Morrissey Janice S Lai Lisha G Brown Ya-Chun Wang Martine P Roudier Ilsa M Coleman Roman Gulati Funda Vakar-Lopez Lawrence D True Eva Corey Peter S Nelson Robert L Vessella

Prostate 2010 Mar;70(4):412-24

Department of Urology, University of Washington, Seattle, Washington 98195, USA.

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March 2010

Comparative analyses of chromosome alterations in soft-tissue metastases within and across patients with castration-resistant prostate cancer.

Authors:
Ilona N Holcomb Janet M Young Ilsa M Coleman Keyan Salari Douglas I Grove Li Hsu Lawrence D True Martine P Roudier Colm M Morrissey Celestia S Higano Peter S Nelson Robert L Vessella Barbara J Trask

Cancer Res 2009 Oct 22;69(19):7793-802. Epub 2009 Sep 22.

Divisions of Human Biology, Fred Hutchinson Cancer Research Center, University of Washington, Seattle, Washington, USA.

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October 2009

Prostate cancer-associated gene expression alterations determined from needle biopsies.

Authors:
David Z Qian Chung-Ying Huang Catherine A O'Brien Ilsa M Coleman Mark Garzotto Lawrence D True Celestia S Higano Robert Vessella Paul H Lange Peter S Nelson Tomasz M Beer

Clin Cancer Res 2009 May 14;15(9):3135-42. Epub 2009 Apr 14.

Division of Hematology and Medical Oncology, Oregon Health and Science University, OR, USA.

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May 2009

Coevolution of prostate cancer and bone stroma in three-dimensional coculture: implications for cancer growth and metastasis.

Authors:
Shian-Ying Sung Chia-Ling Hsieh Andrew Law Haiyen E Zhau Sen Pathak Asha S Multani Sharon Lim Ilsa M Coleman Li-Chin Wu William D Figg William L Dahut Peter Nelson Jae K Lee Mahul B Amin Robert Lyles Peter A J Johnstone Fray F Marshall Leland W K Chung

Cancer Res 2008 Dec;68(23):9996-10003

Department of Urology, Emory University School of Medicine, Atlanta, Georgia 30322, USA.

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December 2008

Mitochondrial DNA mutation stimulates prostate cancer growth in bone stromal environment.

Authors:
Rebecca S Arnold Carrie Q Sun Jendai C Richards Galina Grigoriev Ilsa M Coleman Peter S Nelson Chia-Ling Hsieh Jae K Lee Zhiheng Xu Andre Rogatko Adeboye O Osunkoya Majd Zayzafoon Leland Chung John A Petros

Prostate 2009 Jan;69(1):1-11

Department of Urology, Emory University School of Medicine, Atlanta, Georgia 30322, USA.

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January 2009

Correlation of mRNA and protein levels: cell type-specific gene expression of cluster designation antigens in the prostate.

Authors:
Laura E Pascal Lawrence D True David S Campbell Eric W Deutsch Michael Risk Ilsa M Coleman Lillian J Eichner Peter S Nelson Alvin Y Liu

BMC Genomics 2008 May 23;9:246. Epub 2008 May 23.

Department of Urology, University of Washington, Seattle WA 98195, USA.

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May 2008