Publications by authors named "Ilka Wittig"

100Publications

Redox Regulation of PPAR in Polarized Macrophages.

PPAR Res 2020 1;2020:8253831. Epub 2020 Jul 1.

Institute of Biochemistry I, Goethe-University Frankfurt, 60590 Frankfurt am Main, Germany.

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http://dx.doi.org/10.1155/2020/8253831DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7350077PMC
July 2020

Human platelets are a source of collagen I.

Haematologica 2020 Jun 18. Epub 2020 Jun 18.

Centre of Molecular Medicine and DZHK, Goethe University, Frankfurt am Main, Germany

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http://dx.doi.org/10.3324/haematol.2020.255612DOI Listing
June 2020

Cyp2c44 regulates prostaglandin synthesis, lymphangiogenesis, and metastasis in a mouse model of breast cancer.

Proc Natl Acad Sci U S A 2020 03 2;117(11):5923-5930. Epub 2020 Mar 2.

Institute for Vascular Signalling, Centre for Molecular Medicine, Goethe-University, 60590 Frankfurt am Main, Germany;

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http://dx.doi.org/10.1073/pnas.1921381117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7084120PMC
March 2020

Pathogenic Bi-allelic Mutations in NDUFAF8 Cause Leigh Syndrome with an Isolated Complex I Deficiency.

Am J Hum Genet 2020 01 19;106(1):92-101. Epub 2019 Dec 19.

Wellcome Centre for Mitochondrial Research, Newcastle University, Framlington Place, Newcastle upon Tyne, NE2 4HH, UK; NHS Highly Specialised Services for Rare Mitochondrial Disorders, Royal Victoria Infirmary, Newcastle upon Tyne Hospitals NHS Foundation Trust, Queen Victoria Road, Newcastle upon Tyne, NE1 4LP, UK. Electronic address:

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http://dx.doi.org/10.1016/j.ajhg.2019.12.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7042492PMC
January 2020

Identification of TRIM25 as a Negative Regulator of Caspase-2 Expression Reveals a Novel Target for Sensitizing Colon Carcinoma Cells to Intrinsic Apoptosis.

Cells 2019 12 12;8(12). Epub 2019 Dec 12.

Institute of General Pharmacology and Toxicology, University Hospital, Goethe University Frankfurt am Main, D-60590 Frankfurt, Germany.

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http://dx.doi.org/10.3390/cells8121622DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6952940PMC
December 2019

Bioenergetic consequences from xenotopic expression of a tunicate AOX in mouse mitochondria: Switch from RET and ROS to FET.

Biochim Biophys Acta Bioenerg 2020 02 9;1861(2):148137. Epub 2019 Dec 9.

Biochemistry & Biomedicine, School of Life Sciences, University of Sussex, Falmer BN19QG, Brighton, UK.

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http://dx.doi.org/10.1016/j.bbabio.2019.148137DOI Listing
February 2020

Mutations in a conserved loop in the PSST subunit of respiratory complex I affect ubiquinone binding and dynamics.

Biochim Biophys Acta Bioenerg 2019 07 19;1860(7):573-581. Epub 2019 Jun 19.

Structural Bioenergetics Group, Institute of Biochemistry II, Medical School, Goethe-University, Frankfurt am Main, Germany; Centre for Biomolecular Magnetic Resonance, Institute for Biophysical Chemistry, University of Frankfurt, Frankfurt am Main, Germany; Cluster of Excellence Frankfurt "Macromolecular Complexes", Goethe-University, Frankfurt am Main, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.bbabio.2019.06.006DOI Listing
July 2019

AKAP12 deficiency impairs VEGF-induced endothelial cell migration and sprouting.

Acta Physiol (Oxf) 2020 01 21;228(1):e13325. Epub 2019 Jun 21.

Institute for Vascular Signalling, Centre for Molecular Medicine, Goethe University, Frankfurt am Main, Germany.

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http://dx.doi.org/10.1111/apha.13325DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6916389PMC
January 2020

TLR2-Dependent Reversible Oxidation of Connexin 43 at Cys260 Modifies Electrical Coupling After Experimental Myocardial Ischemia/Reperfusion.

J Cardiovasc Transl Res 2019 10 8;12(5):478-487. Epub 2019 Apr 8.

Department of Anaesthesiology, Intensive Care Medicine, and Pain Therapy, University Hospital Frankfurt, Theodor-Stern-Kai 7, 60590, Frankfurt, Germany.

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http://dx.doi.org/10.1007/s12265-019-09887-0DOI Listing
October 2019

BIAM switch assay coupled to mass spectrometry identifies novel redox targets of NADPH oxidase 4.

Redox Biol 2019 02 29;21:101125. Epub 2019 Jan 29.

Institute for Cardiovascular Physiology, Goethe-University, Frankfurt, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.redox.2019.101125DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360804PMC
February 2019

Nitric oxide contributes to protein homeostasis by S-nitrosylations of the chaperone HSPA8 and the ubiquitin ligase UBE2D.

Redox Biol 2019 01 16;20:217-235. Epub 2018 Oct 16.

Institute for Clinical Pharmacology, Goethe-University Hospital, 60590 Frankfurt am Main, Germany. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S22132317183066
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http://dx.doi.org/10.1016/j.redox.2018.10.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6202877PMC
January 2019

TMEM126B deficiency reduces mitochondrial SDH oxidation by LPS, attenuating HIF-1α stabilization and IL-1β expression.

Redox Biol 2019 01 19;20:204-216. Epub 2018 Oct 19.

Institute of Biochemistry I, Faculty of Medicine, Goethe-University Frankfurt, Germany. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S22132317183077
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http://dx.doi.org/10.1016/j.redox.2018.10.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6202876PMC
January 2019

Oxidation of cardiac myofilament proteins: Priming for dysfunction?

Mol Aspects Med 2018 10 23;63:47-58. Epub 2018 Aug 23.

King's British Heart Foundation Centre, King's College London, UK.

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http://dx.doi.org/10.1016/j.mam.2018.08.003DOI Listing
October 2018

Metabolic Maturation during Muscle Stem Cell Differentiation Is Achieved by miR-1/133a-Mediated Inhibition of the Dlk1-Dio3 Mega Gene Cluster.

Cell Metab 2018 May 5;27(5):1026-1039.e6. Epub 2018 Apr 5.

Max-Planck-Institute for Heart and Lung Research, Department of Cardiac Development and Remodeling, Ludwigstrasse 43, 61231 Bad Nauheim, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2018.02.022DOI Listing
May 2018

Degradation of the mitochondrial complex I assembly factor TMEM126B under chronic hypoxia.

Cell Mol Life Sci 2018 08 20;75(16):3051-3067. Epub 2018 Feb 20.

Faculty of Medicine, Institute of Biochemistry I, Goethe-University Frankfurt, Theodor-Stern-Kai 7, 60590, Frankfurt, Germany.

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http://dx.doi.org/10.1007/s00018-018-2779-yDOI Listing
August 2018

Identification of the TXNIP IRES and characterization of the impact of regulatory IRES trans-acting factors.

Biochim Biophys Acta Gene Regul Mech 2018 Feb 31;1861(2):147-157. Epub 2018 Jan 31.

Institute of Biochemistry I, Faculty of Medicine, Goethe-University Frankfurt, 60590 Frankfurt, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.bbagrm.2018.01.010DOI Listing
February 2018

An artificial transport metabolon facilitates improved substrate utilization in yeast.

Nat Chem Biol 2017 Nov 4;13(11):1158-1163. Epub 2017 Sep 4.

Institute of Molecular Biosciences, Goethe University, Frankfurt am Main, Germany.

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http://dx.doi.org/10.1038/nchembio.2457DOI Listing
November 2017

Cristae architecture is determined by an interplay of the MICOS complex and the FF ATP synthase via Mic27 and Mic10.

Microb Cell 2017 Jul 20;4(8):259-272. Epub 2017 Jul 20.

Cluster of Excellence Macromolecular Complexes, Goethe University Frankfurt, Max-von-Laue-Str. 15, Frankfurt am Main, Germany.

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http://dx.doi.org/10.15698/mic2017.08.585DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5568431PMC
July 2017

Acyl modification and binding of mitochondrial ACP to multiprotein complexes.

Biochim Biophys Acta Mol Cell Res 2017 Oct 9;1864(10):1913-1920. Epub 2017 Aug 9.

Goethe University Frankfurt, Medical School, Institute of Biochemistry II, Structural Bioenergetics Group, Max-von-Laue Str. 9, 60438 Frankfurt, Germany; Cluster of Excellence Macromolecular Complexes, Goethe University Frankfurt, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.bbamcr.2017.08.006DOI Listing
October 2017

Coi1 is a novel assembly factor of the yeast complex III-complex IV supercomplex.

Mol Biol Cell 2017 Aug 9. Epub 2017 Aug 9.

Interfaculty Institute of Biochemistry, University of Tübingen, Hoppe-Seyler-Str. 4, 72076 Tübingen, Germany

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http://dx.doi.org/10.1091/mbc.E17-02-0093DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5620370PMC
August 2017

Loss of synaptic zinc transport in progranulin deficient mice may contribute to progranulin-associated psychopathology and chronic pain.

Biochim Biophys Acta Mol Basis Dis 2017 11 15;1863(11):2727-2745. Epub 2017 Jul 15.

Institute of Clinical Pharmacology, Goethe-University Hospital, Frankfurt, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.bbadis.2017.07.014DOI Listing
November 2017

Cellular differentiation state modulates the mRNA export activity of SR proteins.

J Cell Biol 2017 07 7;216(7):1993-2009. Epub 2017 Jun 7.

Cluster of Excellence Macromolecular Complexes, Institute of Cell Biology and Neuroscience, Goethe University Frankfurt, Frankfurt am Main, Germany

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http://dx.doi.org/10.1083/jcb.201610051DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5496613PMC
July 2017

Rab7-a novel redox target that modulates inflammatory pain processing.

Pain 2017 07;158(7):1354-1365

aInstitute of Pharmacology, College of Pharmacy, Goethe University, Frankfurt am Main, Germany bPharmazentrum Frankfurt/ZAFES, Institute of Clinical Pharmacology, Goethe University, Frankfurt am Main, Germany cFunctional Proteomics, SFB815 Core Unit, Goethe University, Frankfurt am Main, Germany dInstitute of Pharmacology and Toxicology, ZBAF, Witten/Herdecke University, Witten, Germany eFraunhofer Institute for Molecular Biology and Applied Ecology-Project Group Translational Medicine and Pharmacology (IME-TMP), Frankfurt am Main, Germany fDevelopmental and Cell Biology, University of California, Irvine, CA, USA.

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http://dx.doi.org/10.1097/j.pain.0000000000000920DOI Listing
July 2017

Long Noncoding RNA MANTIS Facilitates Endothelial Angiogenic Function.

Circulation 2017 Jul 28;136(1):65-79. Epub 2017 Mar 28.

From Institute for Cardiovascular Physiology (M.S.L., C.F., I.J., M.J.M., J.E., F.M., R.P.B.), Functional Proteomics, SFB 815 Core Unit, Faculty of Medicine (F.M.R., J.H., I.W.), Institute of Vascular Signalling (J.H.), Institute of Cardiovascular Regeneration (P.H. Y.P., S.U., K.S., R.A.B., S.D.), Department of Neurosurgery (T.M.F.), Pharmazentrum Frankfurt, Institute of General Pharmacology and Toxicology (K.D.), Goethe University, Germany; ECCPS Bioinformatics and Sequencing Facility (J.P., S.G., C.K., M.L.) and Department of Lung Development and Remodeling (C.V., S.S.P.), Max-Planck-Institute for Heart and Lung Research, Bad Nauheim, Germany; Institute of Neurology (K.H.P., M.M., K.D.); Department of Vascular and Endovascular Surgery, Klinikum Rechts der Isar, Technical University Munich, Germany (L.M.); Luxembourg Centre of Neuropathology (M.M.); Laboratoire National de Santé, Dudelange, Luxembourg (M.M.); Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Esch-sur-Alzette (M.M.); NORLUX Neuro-Oncology Laboratory, Department of Oncology, Luxembourg Institute of Health (M.M.); Cardiovascular Innovation Institute, University of Louisville, KY (S.U.); Department of Internal Medicine, Member of the German Center for Lung Research (DZL), Justus-Liebig University, Giessen, Germany (R.T.S., N.W., S.S.P.); Department of Medicine, Duke University and Durham VA Medical Center, NC (F.J.M.); and German Center of Cardiovascular Research (DZHK), Partner Site RheinMain, Frankfurt, Germany (M.S.L., C.F., I.J., J.H., J.E., P.H., F.M., Y.P., K.H.P., K.S., I.W., R.A.B., S.D., R.P.B.).

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http://dx.doi.org/10.1161/CIRCULATIONAHA.116.026991DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5491227PMC
July 2017

Mutational Analysis of the QRRQ Motif in the Yeast Hig1 Type 2 Protein Rcf1 Reveals a Regulatory Role for the Cytochrome Oxidase Complex.

J Biol Chem 2017 03 6;292(13):5216-5226. Epub 2017 Feb 6.

From the Department of Biological Sciences, Marquette University, Milwaukee, Wisconsin 53233 and

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http://www.jbc.org/lookup/doi/10.1074/jbc.M116.758045
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http://dx.doi.org/10.1074/jbc.M116.758045DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5392669PMC
March 2017

Cytochrome c Oxidase Biogenesis and Metallochaperone Interactions: Steps in the Assembly Pathway of a Bacterial Complex.

PLoS One 2017 20;12(1):e0170037. Epub 2017 Jan 20.

Institute of Biochemistry, Molecular Genetics, Goethe-University, Frankfurt am Main, Germany.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0170037PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5249081PMC
August 2017

ArgC-Like Digestion: Complementary or Alternative to Tryptic Digestion?

J Proteome Res 2017 02 11;16(2):978-987. Epub 2017 Jan 11.

Institute of Pharmaceutical Chemistry, Goethe-University , Frankfurt am Main 60438, Germany.

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http://dx.doi.org/10.1021/acs.jproteome.6b00921DOI Listing
February 2017

Calpain 1 cleaves and inactivates prostacyclin synthase in mesenteric arteries from diabetic mice.

Basic Res Cardiol 2017 01 24;112(1):10. Epub 2016 Dec 24.

Centre for Molecular Medicine, Institute for Vascular Signalling, Goethe University, Theodor-Stern-Kai 7, 60596, Frankfurt Am Main, Germany.

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http://dx.doi.org/10.1007/s00395-016-0596-8DOI Listing
January 2017

The mitochondrial complexome of Arabidopsis thaliana.

Plant J 2017 Mar 20;89(6):1079-1092. Epub 2017 Feb 20.

Institut für Pflanzengenetik, Leibniz Universität Hannover, Herrenhäuser Str. 2, Hannover, 30419, Germany.

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http://dx.doi.org/10.1111/tpj.13448DOI Listing
March 2017

Data file of a deep proteome analysis of the prefrontal cortex in aged mice with progranulin deficiency or neuronal overexpression of progranulin.

Data Brief 2016 Dec 19;9:1070-1073. Epub 2016 Nov 19.

Institute of Clinical Pharmacology, Goethe-University Hospital, Frankfurt, Germany.

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http://dx.doi.org/10.1016/j.dib.2016.11.030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5126127PMC
December 2016

Accessory subunit NUYM (NDUFS4) is required for stability of the electron input module and activity of mitochondrial complex I.

Biochim Biophys Acta Bioenerg 2017 Feb 19;1858(2):175-181. Epub 2016 Nov 19.

Structural Bioenergetics Group, Institute of Biochemistry II, Medical School, Goethe-University Frankfurt am Main, Germany; Cluster of Excellence Frankfurt "Macromolecular Complexes", Goethe-University Frankfurt am Main, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.bbabio.2016.11.010DOI Listing
February 2017

A Bak-dependent mitochondrial amplification step contributes to Smac mimetic/glucocorticoid-induced necroptosis.

Cell Death Differ 2017 01 11;24(1):83-97. Epub 2016 Nov 11.

Institute for Experimental Cancer Research in Pediatrics, Goethe-University, Komturstraße 3a, 60528 Frankfurt, Germany.

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http://dx.doi.org/10.1038/cdd.2016.102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5260489PMC
January 2017

Recognition of enzymes lacking bound cofactor by protein quality control.

Proc Natl Acad Sci U S A 2016 10 12;113(43):12156-12161. Epub 2016 Oct 12.

Buchmann Institute for Molecular Life Sciences, Goethe University Frankfurt, D-60438 Frankfurt am Main, Germany; Institute of Biophysical Chemistry, Goethe University Frankfurt, D-60438 Frankfurt am Main, Germany;

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http://www.pnas.org/lookup/doi/10.1073/pnas.1611994113
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http://dx.doi.org/10.1073/pnas.1611994113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5087029PMC
October 2016

AMP-Activated Protein Kinase α2 in Neutrophils Regulates Vascular Repair via Hypoxia-Inducible Factor-1α and a Network of Proteins Affecting Metabolism and Apoptosis.

Circ Res 2017 Jan 24;120(1):99-109. Epub 2016 Oct 24.

From the Institute for Vascular Signaling, Centre for Molecular Medicine (R.A.M., N.Z., T.F., S.Z., B.F., I.F.), Functional Proteomics, SFB 815 Core Unit, Faculty of Medicine (J.H., I.W.), ECCPS Metabolomics Facility, Institute for Vascular Signaling, Centre for Molecular Medicine (S.Z.), Department of Hematology/Oncology (S.W., M.A.R.), and Buchmann Institute for Molecular Life Sciences (N.A., F.P.), Goethe University, Frankfurt am Main, Germany; German Center of Cardiovascular Research (DZHK), Partner site Rhein-Main, Frankfurt am Main, Germany (R.A.M., T.F., J.H., S.Z., B.F., I.F.); and Walter-Brendel-Centre of Experimental Medicine, Department of Cardiovascular Physiology and Pathophysiology, Ludwig Maximilians University, Munich, Germany (B.W.).

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http://dx.doi.org/10.1161/CIRCRESAHA.116.309937DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5213742PMC
January 2017

Progranulin promotes peripheral nerve regeneration and reinnervation: role of notch signaling.

Mol Neurodegener 2016 10 22;11(1):69. Epub 2016 Oct 22.

Institute of Clinical Pharmacology, Goethe-University Hospital, Frankfurt, Germany.

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http://dx.doi.org/10.1186/s13024-016-0132-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5075406PMC
October 2016

Mic13 Is Essential for Formation of Crista Junctions in Mammalian Cells.

PLoS One 2016 1;11(8):e0160258. Epub 2016 Aug 1.

Institute of Biochemistry and Molecular Biology I, Heinrich Heine University, Medical Faculty, Universitätsstr. 1, 40225, Düsseldorf, Germany.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0160258PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4968808PMC
August 2017

AMPK activates LXRα and ABCA1 expression in human macrophages.

Int J Biochem Cell Biol 2016 09 22;78:1-9. Epub 2016 Jun 22.

Goethe-University Frankfurt, Faculty of Medicine, Institute of Biochemistry I, Theodor-Stern-Kai 7, 60590 Frankfurt, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.biocel.2016.06.014DOI Listing
September 2016

sST2 translation is regulated by FGF2 via an hnRNP A1-mediated IRES-dependent mechanism.

Biochim Biophys Acta 2016 Jul 8;1859(7):848-59. Epub 2016 May 8.

Institute of Biochemistry I, Faculty of Medicine, Goethe-University Frankfurt, 60590 Frankfurt, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.bbagrm.2016.05.005DOI Listing
July 2016

Supercomplex-associated Cox26 protein binds to cytochrome c oxidase.

Biochim Biophys Acta 2016 Jul 16;1863(7 Pt A):1643-52. Epub 2016 Apr 16.

Molekulare Bioenergetik, Zentrum der Biologischen Chemie, Cluster of Excellence Frankfurt Macromolecular Complexes Goethe-Universität Frankfurt, D-60590 Frankfurt, Germany; Functional Proteomics, Institute of Biochemistry I, Faculty of Medicine, Goethe-University of Frankfurt, D-60590 Frankfurt, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.bbamcr.2016.04.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7140176PMC
July 2016

Interleukin-38 is released from apoptotic cells to limit inflammatory macrophage responses.

J Mol Cell Biol 2016 Oct;8(5):426-438

Institute of Biochemistry I/ZAFES, Faculty of Medicine, Goethe-University Frankfurt, 60590 Frankfurt, Germany.

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http://dx.doi.org/10.1093/jmcb/mjw006DOI Listing
October 2016

The Endoplasmic Reticulum Chaperone Calnexin Is a NADPH Oxidase NOX4 Interacting Protein.

J Biol Chem 2016 Mar 9;291(13):7045-59. Epub 2016 Feb 9.

From the Institut für Kardiovaskuläre Physiologie, Goethe-Universität, Frankfurt am Main, 60590 Germany, the German Center for Cardiovascular Research (DZHK), Partner site RheinMain, 60590 Frankfurt am Main, Germany

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http://www.jbc.org/content/early/2016/02/09/jbc.M115.710772.
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http://www.jbc.org/lookup/doi/10.1074/jbc.M115.710772
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http://dx.doi.org/10.1074/jbc.M115.710772DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4807287PMC
March 2016

An Impaired Respiratory Electron Chain Triggers Down-regulation of the Energy Metabolism and De-ubiquitination of Solute Carrier Amino Acid Transporters.

Mol Cell Proteomics 2016 05 6;15(5):1526-38. Epub 2016 Feb 6.

From the ‡Max Planck Institute for Molecular Genetics, Ihnestraße 63-73, 14195 Berlin, Germany;

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http://dx.doi.org/10.1074/mcp.M115.053181DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4858937PMC
May 2016

S-glutathiolation impairs phosphoregulation and function of cardiac myosin-binding protein C in human heart failure.

FASEB J 2016 05 2;30(5):1849-64. Epub 2016 Feb 2.

Department of Experimental Pharmacology and Toxicology, Cardiovascular Research Center, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; German Center for Cardiovascular Research (DZHK), Partner Site Hamburg/Kiel/Lübeck, Frankfurt, Germany;

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http://www.fasebj.org/content/early/2016/02/02/fj.201500048.
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http://www.fasebj.org/cgi/doi/10.1096/fj.201500048
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http://dx.doi.org/10.1096/fj.201500048DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4836368PMC
May 2016

Hodgkin and Reed-Sternberg cells of classical Hodgkin lymphoma are highly dependent on oxidative phosphorylation.

Int J Cancer 2016 May 18;138(9):2231-46. Epub 2016 Jan 18.

Dr. Senckenberg Institute of Pathology, Goethe-University Hospital, Theodor-Stern-Kai 7, Frankfurt Am Main, 60596, Germany.

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http://dx.doi.org/10.1002/ijc.29934DOI Listing
May 2016

Dicer cleavage by calpain determines platelet microRNA levels and function in diabetes.

Circ Res 2015 Jul 5;117(2):157-65. Epub 2015 May 5.

From the Institute for Vascular Signaling, Centre for Molecular Medicine, and DZHK (German Centre for Cardiovascular Research) partner site Rhine-Main, Frankfurt, Germany (A.E., L.S., J.H., H.L., V.R., I.F.); Functional Proteomics, SFB 815 Core Unit, Goethe-University, Frankfurt, Germany (I.W.); Walter-Brendel-Centre of Experimental Medicine and DZHK partner site Munich Heart Alliance, Ludwig-Maximilians-Universität, Munich, Germany (J.P.); Endokrinologikum Frankfurt, Frankfurt, Germany (A.M.); and Centre Hospitalier Universitaire de Québec Research Center, and Faculty of Medicine, Université Laval, Quebec, Canada (P.P.).

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http://dx.doi.org/10.1161/CIRCRESAHA.117.305784DOI Listing
July 2015

MTO1-deficient mouse model mirrors the human phenotype showing complex I defect and cardiomyopathy.

PLoS One 2014 15;9(12):e114918. Epub 2014 Dec 15.

Department of Neurology, Friedrich-Baur-Institute, Ludwig-Maximilians-University, Munich, Germany; German Mouse Clinic, Helmholtz Zentrum München, German Research Center for Environment and Health, Neuherberg, Germany; German Center for Neurodegenerative Diseases (DZNE), Munich, Germany; German Center for Vertigo and Balance Disorders, Munich, Germany; German Network for Mitochondrial Disorders (mitoNET), Munich, Germany.

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http://pubman.mpdl.mpg.de/pubman/item/escidoc:2147508:2/comp
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http://dx.plos.org/10.1371/journal.pone.0114918
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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0114918PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4266617PMC
November 2015

Autophagy-dependent PELI3 degradation inhibits proinflammatory IL1B expression.

Autophagy 2014 30;10(11):1937-52. Epub 2014 Oct 30.

a Institute of Biochemistry I-Pathobiochemistry; Goethe University Frankfurt; Faculty of Medicine ; Frankfurt , Germany.

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http://dx.doi.org/10.4161/auto.32178DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4502728PMC
September 2015

Generator-specific targets of mitochondrial reactive oxygen species.

Free Radic Biol Med 2015 Jan 29;78:1-10. Epub 2014 Oct 29.

Molecular Bioenergetics Group, Goethe-University, D-60590 Frankfurt am Main, Germany; Clinic of Anaesthesiology, Intensive Care Medicine and Pain Therapy, Goethe-University Hospital, Frankfurt am Main, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.freeradbiomed.2014.10.511DOI Listing
January 2015

NOVA: a software to analyze complexome profiling data.

Bioinformatics 2015 Feb 9;31(3):440-1. Epub 2014 Oct 9.

Molecular Bioinformatics Group, Institute of Computer Science, Faculty of Computer Science and Mathematics, Cluster of Excellence Frankfurt "Macromolecular Complexes", Goethe-University, Robert-Mayer-Str. 11-15, 60325 Frankfurt am Main, Germany, Molecular Bioenergetics Group, Medical School, Cluster of Excellence Frankfurt "Macromolecular Complexes", Goethe-University, Theodor-Stern-Kai 7, 60590 Frankfurt am Main, Germany, Functional Proteomics, SFB815 core unit, Medical School, Goethe-University, Theodor-Stern-Kai 7, 60590 Frankfurt am Main, Germany and Nijmegen Centre for Mitochondrial Disorders, Radboud University Medical Centre, 6525 GA, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1093/bioinformatics/btu623DOI Listing
February 2015

SYNCRIP-dependent Nox2 mRNA destabilization impairs ROS formation in M2-polarized macrophages.

Antioxid Redox Signal 2014 Dec 29;21(18):2483-97. Epub 2014 Jul 29.

1 Faculty of Medicine, Institute of Biochemistry I-Pathobiochemistry, Goethe-University Frankfurt , Frankfurt, Germany .

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http://dx.doi.org/10.1089/ars.2013.5760DOI Listing
December 2014

The LYR protein subunit NB4M/NDUFA6 of mitochondrial complex I anchors an acyl carrier protein and is essential for catalytic activity.

Proc Natl Acad Sci U S A 2014 Apr 24;111(14):5207-12. Epub 2014 Mar 24.

Institute of Biochemistry II, Structural Bioenergetics Group, Medical School, Goethe University Frankfurt, 60438 Frankfurt, Germany.

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http://dx.doi.org/10.1073/pnas.1322438111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3986132PMC
April 2014

Mitochondrial membrane assembly of TMEM70 protein.

Mitochondrion 2014 Mar 25;15:1-9. Epub 2014 Feb 25.

Institute of Physiology Academy of Sciences of the Czech Republic v.v.i., 14220 Prague, Czech Republic. Electronic address:

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http://dx.doi.org/10.1016/j.mito.2014.02.010DOI Listing
March 2014

Mitochondrial respiratory chain complexes as sources and targets of thiol-based redox-regulation.

Biochim Biophys Acta 2014 Aug 19;1844(8):1344-54. Epub 2014 Feb 19.

Functional Proteomics, SFB 815 Core Unit, Faculty of Medicine, Johann Wolfgang Goethe University, 60590 Frankfurt am Main, Germany; Cluster of Excellence "Macromolecular Complexes", Goethe-University, Frankfurt am Main, Germany.

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http://dx.doi.org/10.1016/j.bbapap.2014.02.006DOI Listing
August 2014

ND3, ND1 and 39kDa subunits are more exposed in the de-active form of bovine mitochondrial complex I.

Biochim Biophys Acta 2014 Jun 21;1837(6):929-39. Epub 2014 Feb 21.

Queen's University Belfast, School of Biological Sciences, Medical Biology Centre, 97 Lisburn Road, Belfast BT9 7BL, UK. Electronic address:

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http://dx.doi.org/10.1016/j.bbabio.2014.02.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4331043PMC
June 2014

Chronic hypoxia alters mitochondrial composition in human macrophages.

Biochim Biophys Acta 2013 Dec 16;1834(12):2750-60. Epub 2013 Oct 16.

Institute of Biochemistry I/ZAFES, Goethe-University Frankfurt, 60590 Frankfurt, Germany.

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http://dx.doi.org/10.1016/j.bbapap.2013.09.023DOI Listing
December 2013

Endo-PDI is required for TNFα-induced angiogenesis.

Free Radic Biol Med 2013 Dec 5;65:1398-1407. Epub 2013 Oct 5.

Institut für Kardiovaskuläre Physiologie, Goethe-Universität, 60590 Frankfurt am Main, Germany. Electronic address:

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December 2013

Methods to analyse composition and dynamics of macromolecular complexes.

Biochem Soc Trans 2013 Oct;41(5):1235-41

*Functional Proteomics, SFB815 Core Unit, Faculty of Medicine, Goethe-University, Theodor-Stern-Kai 7, D-60590 Frankfurt am Main, Germany.

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http://biochemsoctrans.org/lookup/doi/10.1042/BST20130153
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October 2013

5-Lipoxygenase contributes to PPARγ activation in macrophages in response to apoptotic cells.

Cell Signal 2013 Dec 13;25(12):2762-8. Epub 2013 Sep 13.

Institute of Biochemistry I-Pathobiochemistry, Faculty of Medicine, Goethe-University Frankfurt, Theodor-Stern-Kai 7, 60590 Frankfurt, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.cellsig.2013.08.045DOI Listing
December 2013

Quantification of protein complexes by blue native electrophoresis.

Methods Mol Biol 2013 ;1033:363-79

Department of Molecular Hematology, University of Frankfurt Medical School, Frankfurt, Germany.

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http://dx.doi.org/10.1007/978-1-62703-487-6_23DOI Listing
March 2014

Age-related changes in the mitochondrial proteome of the fungus Podospora anserina analyzed by 2D-DIGE and LC-MS/MS.

J Proteomics 2013 Oct 19;91:358-74. Epub 2013 Jul 19.

Molecular Bioenergetics Group, Medical School, Cluster of Excellence Frankfurt Macromolecular Complexes, Centre for Membrane Proteomics, Johann Wolfgang Goethe University, 60590 Frankfurt am Main, Germany.

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http://dx.doi.org/10.1016/j.jprot.2013.07.008DOI Listing
October 2013

Platelet-derived growth factor triggers PKA-mediated signalling by a redox-dependent mechanism in rat renal mesangial cells.

Biochem Pharmacol 2013 Jan 24;85(1):101-8. Epub 2012 Oct 24.

Pharmazentrum Frankfurt/ZAFES, Klinikum der Johann Wolfgang Goethe-Universität, Frankfurt am Main, Germany.

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January 2013