Ilja Demuth

Ilja Demuth

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Ilja Demuth

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Clinical outcome of a patient with lysosomal acid lipase deficiency and first results after initiation of treatment with Sebelipase alfa: A case report.

Mol Genet Metab Rep 2019 Sep 18;20:100479. Epub 2019 Jun 18.

Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health, Lipid Clinic, Interdisciplinary Metabolism Center, Germany.

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http://dx.doi.org/10.1016/j.ymgmr.2019.100479DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6587018PMC
September 2019

Differentiation of MISSLA and Fanconi anaemia by computer-aided image analysis and presentation of two novel MISSLA siblings.

Eur J Hum Genet 2019 Jul 18. Epub 2019 Jul 18.

Institute of Medical Genetics and Human Genetics, Charité-Universitätsmedizin Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health, Berlin, Germany.

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http://dx.doi.org/10.1038/s41431-019-0469-3DOI Listing
July 2019

Sex-specific differences in the association of vitamin D with low lean mass and frailty: Results from the Berlin Aging Study II.

Nutrition 2019 Jun 23;62:1-6. Epub 2018 Nov 23.

Research Group on Geriatrics, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Germany; German Institute for Human Nutrition Potsdam-Rehbrücke, Department of Nutrition and Gerontology, Nuthetal, Germany; University of Potsdam, Institute of Nutritional Science, Nuthetal, Germany.

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https://linkinghub.elsevier.com/retrieve/pii/S08999007183063
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http://dx.doi.org/10.1016/j.nut.2018.11.020DOI Listing
June 2019

Influence of nutritional tyrosine on cognition and functional connectivity in healthy old humans.

Neuroimage 2019 06 7;193:139-145. Epub 2019 Mar 7.

University Clinic Hamburg-Eppendorf, Clinic and Policlinic for Psychiatry and Psychotherapy, Martinistraße 52, 20246, Hamburg, Germany; Max Planck Institute for Human Development, Lise Meitner Group for Environmental Neuroscience, Berlin, Germany. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S10538119193017
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http://dx.doi.org/10.1016/j.neuroimage.2019.03.005DOI Listing
June 2019

Exploring the Relationship of Relative Telomere Length and the Epigenetic Clock in the LipidCardio Cohort.

Int J Mol Sci 2019 Jun 21;20(12). Epub 2019 Jun 21.

Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin and the Berlin Institute of Health, Lipid Clinic at the Interdisciplinary Metabolism Center, 13353 Berlin, Germany.

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http://dx.doi.org/10.3390/ijms20123032DOI Listing
June 2019

Validation of a single factor representing the indicators of metabolic syndrome as a continuous measure of metabolic load and its association with health and cognitive function.

PLoS One 2018 12;13(12):e0208231. Epub 2018 Dec 12.

Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Lipid Clinic at the Interdisciplinary Metabolism Center, Berlin, Germany.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0208231PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6291122PMC
May 2019

Different treatment forms of type II diabetes and the risk of dementia in German health claims data.

Acta Diabetol 2019 May 22. Epub 2019 May 22.

Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Lipid Clinic at the Interdisciplinary Metabolism Center, Berlin, Germany.

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http://link.springer.com/10.1007/s00592-019-01332-7
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http://dx.doi.org/10.1007/s00592-019-01332-7DOI Listing
May 2019

Yeast XRS2 and human NBN gene: Experimental evidence for homology using codon optimized cDNA.

PLoS One 2018 15;13(11):e0207315. Epub 2018 Nov 15.

Charité -Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Institute of Medical and Human Genetics, Berlin, Germany.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0207315PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6237358PMC
April 2019

Disentangling the genetics of lean mass.

Authors:
David Karasik M Carola Zillikens Yi-Hsiang Hsu Ali Aghdassi Kristina Akesson Najaf Amin Inês Barroso David A Bennett Lars Bertram Murielle Bochud Ingrid B Borecki Linda Broer Aron S Buchman Liisa Byberg Harry Campbell Natalia Campos-Obando Jane A Cauley Peggy M Cawthon John C Chambers Zhao Chen Nam H Cho Hyung Jin Choi Wen-Chi Chou Steven R Cummings Lisette C P G M de Groot Phillip L De Jager Ilja Demuth Luda Diatchenko Michael J Econs Gudny Eiriksdottir Anke W Enneman Joel Eriksson Johan G Eriksson Karol Estrada Daniel S Evans Mary F Feitosa Mao Fu Christian Gieger Harald Grallert Vilmundur Gudnason Launer J Lenore Caroline Hayward Albert Hofman Georg Homuth Kim M Huffman Lise B Husted Thomas Illig Erik Ingelsson Till Ittermann John-Olov Jansson Toby Johnson Reiner Biffar Joanne M Jordan Antti Jula Magnus Karlsson Kay-Tee Khaw Tuomas O Kilpeläinen Norman Klopp Jacqueline S L Kloth Daniel L Koller Jaspal S Kooner William E Kraus Stephen Kritchevsky Zoltán Kutalik Teemu Kuulasmaa Johanna Kuusisto Markku Laakso Jari Lahti Thomas Lang Bente L Langdahl Markus M Lerch Joshua R Lewis Christina Lill Lars Lind Cecilia Lindgren Yongmei Liu Gregory Livshits Östen Ljunggren Ruth J F Loos Mattias Lorentzon Jian'an Luan Robert N Luben Ida Malkin Fiona E McGuigan Carolina Medina-Gomez Thomas Meitinger Håkan Melhus Dan Mellström Karl Michaëlsson Braxton D Mitchell Andrew P Morris Leif Mosekilde Maria Nethander Anne B Newman Jeffery R O'Connell Ben A Oostra Eric S Orwoll Aarno Palotie Munro Peacock Markus Perola Annette Peters Richard L Prince Bruce M Psaty Katri Räikkönen Stuart H Ralston Samuli Ripatti Fernando Rivadeneira John A Robbins Jerome I Rotter Igor Rudan Veikko Salomaa Suzanne Satterfield Sabine Schipf Chan Soo Shin Albert V Smith Shad B Smith Nicole Soranzo Timothy D Spector Alena Stancáková Kari Stefansson Elisabeth Steinhagen-Thiessen Lisette Stolk Elizabeth A Streeten Unnur Styrkarsdottir Karin M A Swart Patricia Thompson Cynthia A Thomson Gudmar Thorleifsson Unnur Thorsteinsdottir Emmi Tikkanen Gregory J Tranah André G Uitterlinden Cornelia M van Duijn Natasja M van Schoor Liesbeth Vandenput Peter Vollenweider Henry Völzke Jean Wactawski-Wende Mark Walker Nicholas J Wareham Dawn Waterworth Michael N Weedon H-Erich Wichmann Elisabeth Widen Frances M K Williams James F Wilson Nicole C Wright Laura M Yerges-Armstrong Lei Yu Weihua Zhang Jing Hua Zhao Yanhua Zhou Carrie M Nielson Tamara B Harris Serkalem Demissie Douglas P Kiel Claes Ohlsson

Am J Clin Nutr 2019 Feb;109(2):276-287

Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

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http://dx.doi.org/10.1093/ajcn/nqy272DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6500901PMC
February 2019

Epigenetic Clock and Relative Telomere Length Represent Largely Different Aspects of Aging in the Berlin Aging Study II (BASE-II).

J Gerontol A Biol Sci Med Sci 2019 Jan;74(1):27-32

Lipid Clinic at the Interdisciplinary Metabolism Center, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Germany.

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http://dx.doi.org/10.1093/gerona/gly184DOI Listing
January 2019

The hSNM1B/Apollo variant rs11552449 is associated with cellular sensitivity towards mitomycin C and ionizing radiation.

DNA Repair (Amst) 2018 12 12;72:93-98. Epub 2018 Sep 12.

Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Lipid Clinic at the Interdisciplinary Metabolism Center, Germany; Berlin-Brandenburg Center for Regenerative Medicine (BCRT), Charité University Medicine Berlin, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.dnarep.2018.09.004DOI Listing
December 2018

Mild-to-Moderate Chronic Kidney Disease and Geriatric Outcomes: Analysis of Cross-Sectional Data from the Berlin Aging Study II.

Gerontology 2018 29;64(2):118-126. Epub 2017 Nov 29.

Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Department of Endocrinology and Metabolism, Lipid Clinic, Berlin, Germany.

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http://dx.doi.org/10.1159/000484140DOI Listing
November 2018

Antihypertensive Treatment Patterns and Blood Pressure Control in Older Adults: Results from the Berlin Aging Study II.

Drugs Aging 2018 11;35(11):993-1003

Department of Endocrinology and Metabolism, Charité-Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität Berlin, Berlin Institute of Health, Berlin, Germany.

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http://dx.doi.org/10.1007/s40266-018-0580-0DOI Listing
November 2018

Body mass index is negatively associated with telomere length: a collaborative cross-sectional meta-analysis of 87 observational studies.

Am J Clin Nutr 2018 09;108(3):453-475

Departments of Complex Genetics.

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https://academic.oup.com/ajcn/article/108/3/453/5095489
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http://dx.doi.org/10.1093/ajcn/nqy107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454526PMC
September 2018

Gene Therapy in Lipoprotein Lipase Deficiency: Case Report on the First Patient Treated with Alipogene Tiparvovec Under Daily Practice Conditions.

Hum Gene Ther 2018 04;29(4):520-527

1 Lipid Clinic at the Interdisciplinary Metabolism Center, Charité-Universitätsmedizin Berlin , Berlin, Germany.

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http://dx.doi.org/10.1089/hum.2018.007DOI Listing
April 2018

Polypharmacy as a Risk Factor for Clinically Relevant Sarcopenia: Results From the Berlin Aging Study II.

J Gerontol A Biol Sci Med Sci 2017 Dec;73(1):117-122

Research Group on Geriatrics, Charité - Universitätsmedizin Berlin, Germany.

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http://dx.doi.org/10.1093/gerona/glx074DOI Listing
December 2017

Association between lipoprotein(a) level and type 2 diabetes: no evidence for a causal role of lipoprotein(a) and insulin.

Acta Diabetol 2017 Nov 2;54(11):1031-1038. Epub 2017 Sep 2.

Lipid Clinic at the Interdisciplinary Metabolism Center, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Augustenburger Platz 1, 13353, Berlin, Germany.

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http://dx.doi.org/10.1007/s00592-017-1036-4DOI Listing
November 2017

Erratum: Large meta-analysis of genome-wide association studies identifies five loci for lean body mass.

Authors:
M Carola Zillikens Serkalem Demissie Yi-Hsiang Hsu Laura M Yerges-Armstrong Wen-Chi Chou Lisette Stolk Gregory Livshits Linda Broer Toby Johnson Daniel L Koller Zoltán Kutalik Jian'an Luan Ida Malkin Janina S Ried Albert V Smith Gudmar Thorleifsson Liesbeth Vandenput Jing Hua Zhao Weihua Zhang Ali Aghdassi Kristina Åkesson Najaf Amin Leslie J Baier Inês Barroso David A Bennett Lars Bertram Rainer Biffar Murielle Bochud Michael Boehnke Ingrid B Borecki Aron S Buchman Liisa Byberg Harry Campbell Natalia Campos Obanda Jane A Cauley Peggy M Cawthon Henna Cederberg Zhao Chen Nam H Cho Hyung Jin Choi Melina Claussnitzer Francis Collins Steven R Cummings Philip L De Jager Ilja Demuth Rosalie A M Dhonukshe-Rutten Luda Diatchenko Gudny Eiriksdottir Anke W Enneman Mike Erdos Johan G Eriksson Joel Eriksson Karol Estrada Daniel S Evans Mary F Feitosa Mao Fu Melissa Garcia Christian Gieger Thomas Girke Nicole L Glazer Harald Grallert Jagvir Grewal Bok-Ghee Han Robert L Hanson Caroline Hayward Albert Hofman Eric P Hoffman Georg Homuth Wen-Chi Hsueh Monica J Hubal Alan Hubbard Kim M Huffman Lise B Husted Thomas Illig Erik Ingelsson Till Ittermann John-Olov Jansson Joanne M Jordan Antti Jula Magnus Karlsson Kay-Tee Khaw Tuomas O Kilpeläinen Norman Klopp Jacqueline S L Kloth Heikki A Koistinen William E Kraus Stephen Kritchevsky Teemu Kuulasmaa Johanna Kuusisto Markku Laakso Jari Lahti Thomas Lang Bente L Langdahl Lenore J Launer Jong-Young Lee Markus M Lerch Joshua R Lewis Lars Lind Cecilia Lindgren Yongmei Liu Tian Liu Youfang Liu Östen Ljunggren Mattias Lorentzon Robert N Luben William Maixner Fiona E McGuigan Carolina Medina-Gomez Thomas Meitinger Håkan Melhus Dan Mellström Simon Melov Karl Michaëlsson Braxton D Mitchell Andrew P Morris Leif Mosekilde Anne Newman Carrie M Nielson Jeffrey R O'Connell Ben A Oostra Eric S Orwoll Aarno Palotie Stephen C J Parker Munro Peacock Markus Perola Annette Peters Ozren Polasek Richard L Prince Katri Räikkönen Stuart H Ralston Samuli Ripatti John A Robbins Jerome I Rotter Igor Rudan Veikko Salomaa Suzanne Satterfield Eric E Schadt Sabine Schipf Laura Scott Joban Sehmi Jian Shen Chan Soo Shin Gunnar Sigurdsson Shad Smith Nicole Soranzo Alena Stančáková Elisabeth Steinhagen-Thiessen Elizabeth A Streeten Unnur Styrkarsdottir Karin M A Swart Sian-Tsung Tan Mark A Tarnopolsky Patricia Thompson Cynthia A Thomson Unnur Thorsteinsdottir Emmi Tikkanen Gregory J Tranah Jaakko Tuomilehto Natasja M van Schoor Arjun Verma Peter Vollenweider Henry Völzke Jean Wactawski-Wende Mark Walker Michael N Weedon Ryan Welch H-Erich Wichmann Elisabeth Widen Frances M K Williams James F Wilson Nicole C Wright Weijia Xie Lei Yu Yanhua Zhou John C Chambers Angela Döring Cornelia M van Duijn Michael J Econs Vilmundur Gudnason Jaspal S Kooner Bruce M Psaty Timothy D Spector Kari Stefansson Fernando Rivadeneira André G Uitterlinden Nicholas J Wareham Vicky Ossowski Dawn Waterworth Ruth J F Loos David Karasik Tamara B Harris Claes Ohlsson Douglas P Kiel

Nat Commun 2017 11 7;8(1):1414. Epub 2017 Nov 7.

Hebrew SeniorLife, Institute for Aging Research, Roslindale, MA, 02131, USA.

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http://dx.doi.org/10.1038/s41467-017-01008-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5676783PMC
November 2017

Prevalence of Impaired Kidney Function in the German Elderly: Results from the Berlin Aging Study II (BASE-II).

Gerontology 2017 24;63(3):201-209. Epub 2017 Feb 24.

The Berlin Aging Study II, Research Group on Geriatrics, Charité - Universitätsmedizin Berlin, Berlin, Germany.

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http://dx.doi.org/10.1159/000454831DOI Listing
October 2017

Genome-wide meta-analysis associates HLA-DQA1/DRB1 and LPA and lifestyle factors with human longevity.

Authors:
Peter K Joshi Nicola Pirastu Katherine A Kentistou Krista Fischer Edith Hofer Katharina E Schraut David W Clark Teresa Nutile Catriona L K Barnes Paul R H J Timmers Xia Shen Ilaria Gandin Aaron F McDaid Thomas Folkmann Hansen Scott D Gordon Franco Giulianini Thibaud S Boutin Abdel Abdellaoui Wei Zhao Carolina Medina-Gomez Traci M Bartz Stella Trompet Leslie A Lange Laura Raffield Ashley van der Spek Tessel E Galesloot Petroula Proitsi Lisa R Yanek Lawrence F Bielak Antony Payton Federico Murgia Maria Pina Concas Ginevra Biino Salman M Tajuddin Ilkka Seppälä Najaf Amin Eric Boerwinkle Anders D Børglum Archie Campbell Ellen W Demerath Ilja Demuth Jessica D Faul Ian Ford Alessandro Gialluisi Martin Gögele MariaElisa Graff Aroon Hingorani Jouke-Jan Hottenga David M Hougaard Mikko A Hurme M Arfan Ikram Marja Jylhä Diana Kuh Lannie Ligthart Christina M Lill Ulman Lindenberger Thomas Lumley Reedik Mägi Pedro Marques-Vidal Sarah E Medland Lili Milani Reka Nagy William E R Ollier Patricia A Peyser Peter P Pramstaller Paul M Ridker Fernando Rivadeneira Daniela Ruggiero Yasaman Saba Reinhold Schmidt Helena Schmidt P Eline Slagboom Blair H Smith Jennifer A Smith Nona Sotoodehnia Elisabeth Steinhagen-Thiessen Frank J A van Rooij André L Verbeek Sita H Vermeulen Peter Vollenweider Yunpeng Wang Thomas Werge John B Whitfield Alan B Zonderman Terho Lehtimäki Michele K Evans Mario Pirastu Christian Fuchsberger Lars Bertram Neil Pendleton Sharon L R Kardia Marina Ciullo Diane M Becker Andrew Wong Bruce M Psaty Cornelia M van Duijn James G Wilson J Wouter Jukema Lambertus Kiemeney André G Uitterlinden Nora Franceschini Kari E North David R Weir Andres Metspalu Dorret I Boomsma Caroline Hayward Daniel Chasman Nicholas G Martin Naveed Sattar Harry Campbell Tōnu Esko Zoltán Kutalik James F Wilson

Nat Commun 2017 10 13;8(1):910. Epub 2017 Oct 13.

Centre for Global Health Research, Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, EH8 9AG, UK.

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http://dx.doi.org/10.1038/s41467-017-00934-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5715013PMC
October 2017

Zinc Deficiency Is associated With Depressive Symptoms-Results From the Berlin Aging Study II.

J Gerontol A Biol Sci Med Sci 2017 Aug;72(8):1149-1154

Charité Research Group on Geriatrics.

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http://dx.doi.org/10.1093/gerona/glw218DOI Listing
August 2017

SNM1B/Apollo in the DNA damage response and telomere maintenance.

Oncotarget 2017 Jul;8(29):48398-48409

Lipid Clinic at the Interdisciplinary Metabolism Center, Charité-Universitätsmedizin Berlin, 13353 Berlin, Germany.

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http://dx.doi.org/10.18632/oncotarget.16864DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5564657PMC
July 2017

Large meta-analysis of genome-wide association studies identifies five loci for lean body mass.

Authors:
M Carola Zillikens Serkalem Demissie Yi-Hsiang Hsu Laura M Yerges-Armstrong Wen-Chi Chou Lisette Stolk Gregory Livshits Linda Broer Toby Johnson Daniel L Koller Zoltán Kutalik Jian'an Luan Ida Malkin Janina S Ried Albert V Smith Gudmar Thorleifsson Liesbeth Vandenput Jing Hua Zhao Weihua Zhang Ali Aghdassi Kristina Åkesson Najaf Amin Leslie J Baier Inês Barroso David A Bennett Lars Bertram Rainer Biffar Murielle Bochud Michael Boehnke Ingrid B Borecki Aron S Buchman Liisa Byberg Harry Campbell Natalia Campos Obanda Jane A Cauley Peggy M Cawthon Henna Cederberg Zhao Chen Nam H Cho Hyung Jin Choi Melina Claussnitzer Francis Collins Steven R Cummings Philip L De Jager Ilja Demuth Rosalie A M Dhonukshe-Rutten Luda Diatchenko Gudny Eiriksdottir Anke W Enneman Mike Erdos Johan G Eriksson Joel Eriksson Karol Estrada Daniel S Evans Mary F Feitosa Mao Fu Melissa Garcia Christian Gieger Thomas Girke Nicole L Glazer Harald Grallert Jagvir Grewal Bok-Ghee Han Robert L Hanson Caroline Hayward Albert Hofman Eric P Hoffman Georg Homuth Wen-Chi Hsueh Monica J Hubal Alan Hubbard Kim M Huffman Lise B Husted Thomas Illig Erik Ingelsson Till Ittermann John-Olov Jansson Joanne M Jordan Antti Jula Magnus Karlsson Kay-Tee Khaw Tuomas O Kilpeläinen Norman Klopp Jacqueline S L Kloth Heikki A Koistinen William E Kraus Stephen Kritchevsky Teemu Kuulasmaa Johanna Kuusisto Markku Laakso Jari Lahti Thomas Lang Bente L Langdahl Lenore J Launer Jong-Young Lee Markus M Lerch Joshua R Lewis Lars Lind Cecilia Lindgren Yongmei Liu Tian Liu Youfang Liu Östen Ljunggren Mattias Lorentzon Robert N Luben William Maixner Fiona E McGuigan Carolina Medina-Gomez Thomas Meitinger Håkan Melhus Dan Mellström Simon Melov Karl Michaëlsson Braxton D Mitchell Andrew P Morris Leif Mosekilde Anne Newman Carrie M Nielson Jeffrey R O'Connell Ben A Oostra Eric S Orwoll Aarno Palotie Stephen C J Parker Munro Peacock Markus Perola Annette Peters Ozren Polasek Richard L Prince Katri Räikkönen Stuart H Ralston Samuli Ripatti John A Robbins Jerome I Rotter Igor Rudan Veikko Salomaa Suzanne Satterfield Eric E Schadt Sabine Schipf Laura Scott Joban Sehmi Jian Shen Chan Soo Shin Gunnar Sigurdsson Shad Smith Nicole Soranzo Alena Stančáková Elisabeth Steinhagen-Thiessen Elizabeth A Streeten Unnur Styrkarsdottir Karin M A Swart Sian-Tsung Tan Mark A Tarnopolsky Patricia Thompson Cynthia A Thomson Unnur Thorsteinsdottir Emmi Tikkanen Gregory J Tranah Jaakko Tuomilehto Natasja M van Schoor Arjun Verma Peter Vollenweider Henry Völzke Jean Wactawski-Wende Mark Walker Michael N Weedon Ryan Welch H-Erich Wichmann Elisabeth Widen Frances M K Williams James F Wilson Nicole C Wright Weijia Xie Lei Yu Yanhua Zhou John C Chambers Angela Döring Cornelia M van Duijn Michael J Econs Vilmundur Gudnason Jaspal S Kooner Bruce M Psaty Timothy D Spector Kari Stefansson Fernando Rivadeneira André G Uitterlinden Nicholas J Wareham Vicky Ossowski Dawn Waterworth Ruth J F Loos David Karasik Tamara B Harris Claes Ohlsson Douglas P Kiel

Nat Commun 2017 07 19;8(1):80. Epub 2017 Jul 19.

Hebrew SeniorLife, Institute for Aging Research, Roslindale, MA, 02131, USA.

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http://dx.doi.org/10.1038/s41467-017-00031-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5517526PMC
July 2017

PCSK9 genetic variants and risk of type 2 diabetes: a mendelian randomisation study.

Authors:
Amand F Schmidt Daniel I Swerdlow Michael V Holmes Riyaz S Patel Zammy Fairhurst-Hunter Donald M Lyall Fernando Pires Hartwig Bernardo Lessa Horta Elina Hyppönen Christine Power Max Moldovan Erik van Iperen G Kees Hovingh Ilja Demuth Kristina Norman Elisabeth Steinhagen-Thiessen Juri Demuth Lars Bertram Tian Liu Stefan Coassin Johann Willeit Stefan Kiechl Karin Willeit Dan Mason John Wright Richard Morris Goya Wanamethee Peter Whincup Yoav Ben-Shlomo Stela McLachlan Jackie F Price Mika Kivimaki Catherine Welch Adelaida Sanchez-Galvez Pedro Marques-Vidal Andrew Nicolaides Andrie G Panayiotou N Charlotte Onland-Moret Yvonne T van der Schouw Giuseppe Matullo Giovanni Fiorito Simonetta Guarrera Carlotta Sacerdote Nicholas J Wareham Claudia Langenberg Robert Scott Jian'an Luan Martin Bobak Sofia Malyutina Andrzej Pająk Ruzena Kubinova Abdonas Tamosiunas Hynek Pikhart Lise Lotte Nystrup Husemoen Niels Grarup Oluf Pedersen Torben Hansen Allan Linneberg Kenneth Starup Simonsen Jackie Cooper Steve E Humphries Murray Brilliant Terrie Kitchner Hakon Hakonarson David S Carrell Catherine A McCarty H Lester Kirchner Eric B Larson David R Crosslin Mariza de Andrade Dan M Roden Joshua C Denny Cara Carty Stephen Hancock John Attia Elizabeth Holliday Martin O'Donnell Salim Yusuf Michael Chong Guillaume Pare Pim van der Harst M Abdullah Said Ruben N Eppinga Niek Verweij Harold Snieder Tim Christen Dennis O Mook-Kanamori Stefan Gustafsson Lars Lind Erik Ingelsson Raha Pazoki Oscar Franco Albert Hofman Andre Uitterlinden Abbas Dehghan Alexander Teumer Sebastian Baumeister Marcus Dörr Markus M Lerch Uwe Völker Henry Völzke Joey Ward Jill P Pell Daniel J Smith Tom Meade Anke H Maitland-van der Zee Ekaterina V Baranova Robin Young Ian Ford Archie Campbell Sandosh Padmanabhan Michiel L Bots Diederick E Grobbee Philippe Froguel Dorothée Thuillier Beverley Balkau Amélie Bonnefond Bertrand Cariou Melissa Smart Yanchun Bao Meena Kumari Anubha Mahajan Paul M Ridker Daniel I Chasman Alex P Reiner Leslie A Lange Marylyn D Ritchie Folkert W Asselbergs Juan-Pablo Casas Brendan J Keating David Preiss Aroon D Hingorani Naveed Sattar

Lancet Diabetes Endocrinol 2017 02 29;5(2):97-105. Epub 2016 Nov 29.

Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK. Electronic address:

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http://dx.doi.org/10.1016/S2213-8587(16)30396-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5266795PMC
February 2017

Editorial.

Gerontology 2016 29;62(3):311-5. Epub 2016 Jan 29.

Humboldt University, Berlin, Germany.

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http://dx.doi.org/10.1159/000441495DOI Listing
January 2017

Cytomegalovirus Infection Minimally Affects the Frequencies of B-Cell Phenotypes in Peripheral Blood of Younger and Older Adults.

Gerontology 2016 29;62(3):323-9. Epub 2016 Jan 29.

Department of Internal Medicine II, Centre for Medical Research, Medical School, University of Tx00FC;bingen, Tx00FC;bingen, Germany.

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http://dx.doi.org/10.1159/000382076DOI Listing
January 2017

Relative Leukocyte Telomere Length, Hematological Parameters and Anemia - Data from the Berlin Aging Study II (BASE-II).

Gerontology 2016 29;62(3):330-6. Epub 2016 Jan 29.

Research Group on Geriatrics, Charitx00E9; - Universitx00E4;tsmedizin Berlin, Berlin, Germany.

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http://dx.doi.org/10.1159/000430950DOI Listing
January 2017

Association between Metabolic Syndrome and Bone Mineral Density--Data from the Berlin Aging Study II (BASE-II).

Gerontology 2016 29;62(3):337-44. Epub 2016 Jan 29.

Research Group on Geriatrics, Charitx00E9; - Universitx00E4;tsmedizin Berlin, Berlin, Germany.

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http://dx.doi.org/10.1159/000434678DOI Listing
January 2017

Associations between Neighborhood Characteristics, Well-Being and Health Vary over the Life Course.

Gerontology 2016 29;62(3):362-70. Epub 2016 Jan 29.

Health Economics Research Centre, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1159/000438700DOI Listing
January 2017

Genetic Burden Analyses of Phenotypes Relevant to Aging in the Berlin Aging Study II (BASE-II).

Gerontology 2016 29;62(3):316-22. Epub 2016 Jan 29.

Lx00FC;beck Interdisciplinary Platform for Genome Analytics (LIGA), Institutes of Neurogenetics and Integrative and Experimental Genomics, University of Lx00FC;beck, Lx00FC;beck, Germany.

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http://dx.doi.org/10.1159/000438900DOI Listing
January 2017

Angiotensin-Converting Enzyme Inhibitors and Parameters of Sarcopenia: Relation to Muscle Mass, Strength and Function: Data from the Berlin Aging Study-II (BASE-II).

Drugs Aging 2016 11;33(11):829-837

Charité Research Group on Geriatrics, Charité-Universitätsmedizin Berlin, Reinickendorfer Str. 61, Berlin, 13347, Germany.

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http://dx.doi.org/10.1007/s40266-016-0396-8DOI Listing
November 2016

Clinical characterization and mutation spectrum of German patients with familial hypercholesterolemia.

Atherosclerosis 2016 10 26;253:88-93. Epub 2016 Aug 26.

Institute for Medical and Human Genetics, Charité-Universitätsmedizin Berlin, Augustenburger Platz 1, 13353 Berlin, Germany; The Berlin Aging Study II, Research Group on Geriatrics, Charité-Universitätsmedizin Berlin, Reinickendorfer Str. 61, Berlin, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.atherosclerosis.2016.08.037DOI Listing
October 2016

Responses of Dendritic Cells to TLR-4 Stimulation Are Maintained in the Elderly and Resist the Effects of CMV Infection Seen in the Young.

J Gerontol A Biol Sci Med Sci 2016 09 27;71(9):1117-23. Epub 2015 Nov 27.

Department of Internal Medicine II, Centre for Medical Research, University of Tübingen, Tübingen, Germany.

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http://dx.doi.org/10.1093/gerona/glv119DOI Listing
September 2016

[Pulmonary function in elderly subjects with metabolic syndrome and type II diabetes : Data from the Berlin Aging Study II].

Z Gerontol Geriatr 2016 Jul 27;49(5):405-15. Epub 2015 Oct 27.

Forschungsgruppe Geriatrie am EGZB, Charité - Universitätsmedizin Berlin, Reinickendorfer Str. 61, 13347, Berlin, Deutschland.

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http://dx.doi.org/10.1007/s00391-015-0959-zDOI Listing
July 2016

Higher Lipoprotein (a) Levels Are Associated with Better Pulmonary Function in Community-Dwelling Older People - Data from the Berlin Aging Study II.

PLoS One 2015 30;10(9):e0139040. Epub 2015 Sep 30.

Research Group on Geriatrics, Charité -Universitätsmedizin Berlin, Reinickendorfer Str. 61,13347 Berlin, Germany; Institute of Medical and Human Genetics, Charité -Universitätsmedizin Berlin, Augustenburger Platz 1,13353 Berlin, Germany.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0139040PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4589348PMC
May 2016

Genome-wide association study identifies 74 loci associated with educational attainment.

Authors:
Aysu Okbay Jonathan P Beauchamp Mark Alan Fontana James J Lee Tune H Pers Cornelius A Rietveld Patrick Turley Guo-Bo Chen Valur Emilsson S Fleur W Meddens Sven Oskarsson Joseph K Pickrell Kevin Thom Pascal Timshel Ronald de Vlaming Abdel Abdellaoui Tarunveer S Ahluwalia Jonas Bacelis Clemens Baumbach Gyda Bjornsdottir Johannes H Brandsma Maria Pina Concas Jaime Derringer Nicholas A Furlotte Tessel E Galesloot Giorgia Girotto Richa Gupta Leanne M Hall Sarah E Harris Edith Hofer Momoko Horikoshi Jennifer E Huffman Kadri Kaasik Ioanna P Kalafati Robert Karlsson Augustine Kong Jari Lahti Sven J van der Lee Christiaan deLeeuw Penelope A Lind Karl-Oskar Lindgren Tian Liu Massimo Mangino Jonathan Marten Evelin Mihailov Michael B Miller Peter J van der Most Christopher Oldmeadow Antony Payton Natalia Pervjakova Wouter J Peyrot Yong Qian Olli Raitakari Rico Rueedi Erika Salvi Börge Schmidt Katharina E Schraut Jianxin Shi Albert V Smith Raymond A Poot Beate St Pourcain Alexander Teumer Gudmar Thorleifsson Niek Verweij Dragana Vuckovic Juergen Wellmann Harm-Jan Westra Jingyun Yang Wei Zhao Zhihong Zhu Behrooz Z Alizadeh Najaf Amin Andrew Bakshi Sebastian E Baumeister Ginevra Biino Klaus Bønnelykke Patricia A Boyle Harry Campbell Francesco P Cappuccio Gail Davies Jan-Emmanuel De Neve Panos Deloukas Ilja Demuth Jun Ding Peter Eibich Lewin Eisele Niina Eklund David M Evans Jessica D Faul Mary F Feitosa Andreas J Forstner Ilaria Gandin Bjarni Gunnarsson Bjarni V Halldórsson Tamara B Harris Andrew C Heath Lynne J Hocking Elizabeth G Holliday Georg Homuth Michael A Horan Jouke-Jan Hottenga Philip L de Jager Peter K Joshi Astanand Jugessur Marika A Kaakinen Mika Kähönen Stavroula Kanoni Liisa Keltigangas-Järvinen Lambertus A L M Kiemeney Ivana Kolcic Seppo Koskinen Aldi T Kraja Martin Kroh Zoltan Kutalik Antti Latvala Lenore J Launer Maël P Lebreton Douglas F Levinson Paul Lichtenstein Peter Lichtner David C M Liewald Anu Loukola Pamela A Madden Reedik Mägi Tomi Mäki-Opas Riccardo E Marioni Pedro Marques-Vidal Gerardus A Meddens George McMahon Christa Meisinger Thomas Meitinger Yusplitri Milaneschi Lili Milani Grant W Montgomery Ronny Myhre Christopher P Nelson Dale R Nyholt William E R Ollier Aarno Palotie Lavinia Paternoster Nancy L Pedersen Katja E Petrovic David J Porteous Katri Räikkönen Susan M Ring Antonietta Robino Olga Rostapshova Igor Rudan Aldo Rustichini Veikko Salomaa Alan R Sanders Antti-Pekka Sarin Helena Schmidt Rodney J Scott Blair H Smith Jennifer A Smith Jan A Staessen Elisabeth Steinhagen-Thiessen Konstantin Strauch Antonio Terracciano Martin D Tobin Sheila Ulivi Simona Vaccargiu Lydia Quaye Frank J A van Rooij Cristina Venturini Anna A E Vinkhuyzen Uwe Völker Henry Völzke Judith M Vonk Diego Vozzi Johannes Waage Erin B Ware Gonneke Willemsen John R Attia David A Bennett Klaus Berger Lars Bertram Hans Bisgaard Dorret I Boomsma Ingrid B Borecki Ute Bültmann Christopher F Chabris Francesco Cucca Daniele Cusi Ian J Deary George V Dedoussis Cornelia M van Duijn Johan G Eriksson Barbara Franke Lude Franke Paolo Gasparini Pablo V Gejman Christian Gieger Hans-Jörgen Grabe Jacob Gratten Patrick J F Groenen Vilmundur Gudnason Pim van der Harst Caroline Hayward David A Hinds Wolfgang Hoffmann Elina Hyppönen William G Iacono Bo Jacobsson Marjo-Riitta Järvelin Karl-Heinz Jöckel Jaakko Kaprio Sharon L R Kardia Terho Lehtimäki Steven F Lehrer Patrik K E Magnusson Nicholas G Martin Matt McGue Andres Metspalu Neil Pendleton Brenda W J H Penninx Markus Perola Nicola Pirastu Mario Pirastu Ozren Polasek Danielle Posthuma Christine Power Michael A Province Nilesh J Samani David Schlessinger Reinhold Schmidt Thorkild I A Sørensen Tim D Spector Kari Stefansson Unnur Thorsteinsdottir A Roy Thurik Nicholas J Timpson Henning Tiemeier Joyce Y Tung André G Uitterlinden Veronique Vitart Peter Vollenweider David R Weir James F Wilson Alan F Wright Dalton C Conley Robert F Krueger George Davey Smith Albert Hofman David I Laibson Sarah E Medland Michelle N Meyer Jian Yang Magnus Johannesson Peter M Visscher Tõnu Esko Philipp D Koellinger David Cesarini Daniel J Benjamin

Nature 2016 05 11;533(7604):539-42. Epub 2016 May 11.

Center for Economic and Social Research, University of Southern California, Los Angeles, California 90089-3332, USA.

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http://dx.doi.org/10.1038/nature17671DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4883595PMC
May 2016

Exercise at Different Ages and Appendicular Lean Mass and Strength in Later Life: Results From the Berlin Aging Study II.

J Gerontol A Biol Sci Med Sci 2016 Apr 5;71(4):515-20. Epub 2015 Oct 5.

The Berlin Aging Study II; Research Group on Geriatrics, Charité-Universitätsmedizin Berlin, Germany.

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http://dx.doi.org/10.1093/gerona/glv171DOI Listing
April 2016

Sleep, Muscle Mass and Muscle Function in Older People.

Dtsch Arztebl Int 2016 Apr;113(15):253-60

Geriatrics Research Group, Charité Universitätsmedizin, Berlin, Institute for Medical Genetics and Human Genetics, Charité Universitätsmedizin, Berlin, Rahel Eckardt and Elisabeth Steinhagen-Thiessen are joint last authors.

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http://dx.doi.org/10.3238/arztebl.2016.0253DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4860870PMC
April 2016

No strong correlations between serum cytokine levels, CMV serostatus and hand-grip strength in older subjects in the Berlin BASE-II cohort.

Biogerontology 2016 Feb 24;17(1):189-98. Epub 2015 Apr 24.

Research Group on Geriatrics, Charité - Universitätsmedizin Berlin, Berlin, Germany.

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http://dx.doi.org/10.1007/s10522-015-9577-9DOI Listing
February 2016

Identifying Sarcopenia in Metabolic Syndrome: Data from the Berlin Aging Study II.

J Gerontol A Biol Sci Med Sci 2016 Feb 11;71(2):265-72. Epub 2015 Aug 11.

Research Group on Geriatrics and

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http://dx.doi.org/10.1093/gerona/glv089DOI Listing
February 2016

The inflammatory markers CRP, IL-6, and IL-10 are associated with cognitive function--data from the Berlin Aging Study II.

Neurobiol Aging 2016 Feb 7;38:112-117. Epub 2015 Nov 7.

Research Group on Geriatrics, Charité-Universitätsmedizin Berlin, Berlin, Germany; Institute of Medical and Human Genetics, Charité-Universitätsmedizin Berlin, Berlin, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.neurobiolaging.2015.10.039DOI Listing
February 2016

New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk.

Authors:
Yingchang Lu Felix R Day Stefan Gustafsson Martin L Buchkovich Jianbo Na Veronique Bataille Diana L Cousminer Zari Dastani Alexander W Drong Tõnu Esko David M Evans Mario Falchi Mary F Feitosa Teresa Ferreira Åsa K Hedman Robin Haring Pirro G Hysi Mark M Iles Anne E Justice Stavroula Kanoni Vasiliki Lagou Rui Li Xin Li Adam Locke Chen Lu Reedik Mägi John R B Perry Tune H Pers Qibin Qi Marianna Sanna Ellen M Schmidt William R Scott Dmitry Shungin Alexander Teumer Anna A E Vinkhuyzen Ryan W Walker Harm-Jan Westra Mingfeng Zhang Weihua Zhang Jing Hua Zhao Zhihong Zhu Uzma Afzal Tarunveer Singh Ahluwalia Stephan J L Bakker Claire Bellis Amélie Bonnefond Katja Borodulin Aron S Buchman Tommy Cederholm Audrey C Choh Hyung Jin Choi Joanne E Curran Lisette C P G M de Groot Philip L De Jager Rosalie A M Dhonukshe-Rutten Anke W Enneman Elodie Eury Daniel S Evans Tom Forsen Nele Friedrich Frédéric Fumeron Melissa E Garcia Simone Gärtner Bok-Ghee Han Aki S Havulinna Caroline Hayward Dena Hernandez Hans Hillege Till Ittermann Jack W Kent Ivana Kolcic Tiina Laatikainen Jari Lahti Irene Mateo Leach Christine G Lee Jong-Young Lee Tian Liu Youfang Liu Stéphane Lobbens Marie Loh Leo-Pekka Lyytikäinen Carolina Medina-Gomez Karl Michaëlsson Mike A Nalls Carrie M Nielson Laticia Oozageer Laura Pascoe Lavinia Paternoster Ozren Polašek Samuli Ripatti Mark A Sarzynski Chan Soo Shin Nina Smolej Narančić Dominik Spira Priya Srikanth Elisabeth Steinhagen-Thiessen Yun Ju Sung Karin M A Swart Leena Taittonen Toshiko Tanaka Emmi Tikkanen Nathalie van der Velde Natasja M van Schoor Niek Verweij Alan F Wright Lei Yu Joseph M Zmuda Niina Eklund Terrence Forrester Niels Grarup Anne U Jackson Kati Kristiansson Teemu Kuulasmaa Johanna Kuusisto Peter Lichtner Jian'an Luan Anubha Mahajan Satu Männistö Cameron D Palmer Janina S Ried Robert A Scott Alena Stancáková Peter J Wagner Ayse Demirkan Angela Döring Vilmundur Gudnason Douglas P Kiel Brigitte Kühnel Massimo Mangino Barbara Mcknight Cristina Menni Jeffrey R O'Connell Ben A Oostra Alan R Shuldiner Kijoung Song Liesbeth Vandenput Cornelia M van Duijn Peter Vollenweider Charles C White Michael Boehnke Yvonne Boettcher Richard S Cooper Nita G Forouhi Christian Gieger Harald Grallert Aroon Hingorani Torben Jørgensen Pekka Jousilahti Mika Kivimaki Meena Kumari Markku Laakso Claudia Langenberg Allan Linneberg Amy Luke Colin A Mckenzie Aarno Palotie Oluf Pedersen Annette Peters Konstantin Strauch Bamidele O Tayo Nicholas J Wareham David A Bennett Lars Bertram John Blangero Matthias Blüher Claude Bouchard Harry Campbell Nam H Cho Steven R Cummings Stefan A Czerwinski Ilja Demuth Rahel Eckardt Johan G Eriksson Luigi Ferrucci Oscar H Franco Philippe Froguel Ron T Gansevoort Torben Hansen Tamara B Harris Nicholas Hastie Markku Heliövaara Albert Hofman Joanne M Jordan Antti Jula Mika Kähönen Eero Kajantie Paul B Knekt Seppo Koskinen Peter Kovacs Terho Lehtimäki Lars Lind Yongmei Liu Eric S Orwoll Clive Osmond Markus Perola Louis Pérusse Olli T Raitakari Tuomo Rankinen D C Rao Treva K Rice Fernando Rivadeneira Igor Rudan Veikko Salomaa Thorkild I A Sørensen Michael Stumvoll Anke Tönjes Bradford Towne Gregory J Tranah Angelo Tremblay André G Uitterlinden Pim van der Harst Erkki Vartiainen Jorma S Viikari Veronique Vitart Marie-Claude Vohl Henry Völzke Mark Walker Henri Wallaschofski Sarah Wild James F Wilson Loïc Yengo D Timothy Bishop Ingrid B Borecki John C Chambers L Adrienne Cupples Abbas Dehghan Panos Deloukas Ghazaleh Fatemifar Caroline Fox Terrence S Furey Lude Franke Jiali Han David J Hunter Juha Karjalainen Fredrik Karpe Robert C Kaplan Jaspal S Kooner Mark I McCarthy Joanne M Murabito Andrew P Morris Julia A N Bishop Kari E North Claes Ohlsson Ken K Ong Inga Prokopenko J Brent Richards Eric E Schadt Tim D Spector Elisabeth Widén Cristen J Willer Jian Yang Erik Ingelsson Karen L Mohlke Joel N Hirschhorn John Andrew Pospisilik M Carola Zillikens Cecilia Lindgren Tuomas Oskari Kilpeläinen Ruth J F Loos

Nat Commun 2016 Feb 1;7:10495. Epub 2016 Feb 1.

The Charles Bronfman Institute for Personalized Medicine, The Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.

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http://dx.doi.org/10.1038/ncomms10495DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4740398PMC
February 2016

Peripheral blood T-cell signatures from high-resolution immune phenotyping of γδ and αβ T-cells in younger and older subjects in the Berlin Aging Study II.

Immun Ageing 2015 4;12:25. Epub 2015 Dec 4.

Department of Internal Medicine II, University Medical Center, Waldhörnlestr. 22, Tübingen, 72072 Germany ; The John van Geest Cancer Research Centre, School of Science and Technology, Nottingham Trent University, Clifton Lane, Nottingham, NG11 8NS UK.

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http://dx.doi.org/10.1186/s12979-015-0052-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4670504PMC
December 2015

A comprehensive 1,000 Genomes-based genome-wide association meta-analysis of coronary artery disease.

Authors:
Majid Nikpay Anuj Goel Hong-Hee Won Leanne M Hall Christina Willenborg Stavroula Kanoni Danish Saleheen Theodosios Kyriakou Christopher P Nelson Jemma C Hopewell Thomas R Webb Lingyao Zeng Abbas Dehghan Maris Alver Sebastian M Armasu Kirsi Auro Andrew Bjonnes Daniel I Chasman Shufeng Chen Ian Ford Nora Franceschini Christian Gieger Christopher Grace Stefan Gustafsson Jie Huang Shih-Jen Hwang Yun Kyoung Kim Marcus E Kleber King Wai Lau Xiangfeng Lu Yingchang Lu Leo-Pekka Lyytikäinen Evelin Mihailov Alanna C Morrison Natalia Pervjakova Liming Qu Lynda M Rose Elias Salfati Richa Saxena Markus Scholz Albert V Smith Emmi Tikkanen Andre Uitterlinden Xueli Yang Weihua Zhang Wei Zhao Mariza de Andrade Paul S de Vries Natalie R van Zuydam Sonia S Anand Lars Bertram Frank Beutner George Dedoussis Philippe Frossard Dominique Gauguier Alison H Goodall Omri Gottesman Marc Haber Bok-Ghee Han Jianfeng Huang Shapour Jalilzadeh Thorsten Kessler Inke R König Lars Lannfelt Wolfgang Lieb Lars Lind Cecilia M Lindgren Marja-Liisa Lokki Patrik K Magnusson Nadeem H Mallick Narinder Mehra Thomas Meitinger Fazal-Ur-Rehman Memon Andrew P Morris Markku S Nieminen Nancy L Pedersen Annette Peters Loukianos S Rallidis Asif Rasheed Maria Samuel Svati H Shah Juha Sinisalo Kathleen E Stirrups Stella Trompet Laiyuan Wang Khan S Zaman Diego Ardissino Eric Boerwinkle Ingrid B Borecki Erwin P Bottinger Julie E Buring John C Chambers Rory Collins L Adrienne Cupples John Danesh Ilja Demuth Roberto Elosua Stephen E Epstein Tõnu Esko Mary F Feitosa Oscar H Franco Maria Grazia Franzosi Christopher B Granger Dongfeng Gu Vilmundur Gudnason Alistair S Hall Anders Hamsten Tamara B Harris Stanley L Hazen Christian Hengstenberg Albert Hofman Erik Ingelsson Carlos Iribarren J Wouter Jukema Pekka J Karhunen Bong-Jo Kim Jaspal S Kooner Iftikhar J Kullo Terho Lehtimäki Ruth J F Loos Olle Melander Andres Metspalu Winfried März Colin N Palmer Markus Perola Thomas Quertermous Daniel J Rader Paul M Ridker Samuli Ripatti Robert Roberts Veikko Salomaa Dharambir K Sanghera Stephen M Schwartz Udo Seedorf Alexandre F Stewart David J Stott Joachim Thiery Pierre A Zalloua Christopher J O'Donnell Muredach P Reilly Themistocles L Assimes John R Thompson Jeanette Erdmann Robert Clarke Hugh Watkins Sekar Kathiresan Ruth McPherson Panos Deloukas Heribert Schunkert Nilesh J Samani Martin Farrall

Nat Genet 2015 Oct 7;47(10):1121-1130. Epub 2015 Sep 7.

Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1038/ng.3396DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4589895PMC
October 2015

Lung function in elderly subjects with metabolic syndrome and type II diabetes : Data from the Berlin Aging Study II.

Z Gerontol Geriatr 2015 Oct 27. Epub 2015 Oct 27.

Research Group on Geriatrics, Charité - Universitätsmedizin Berlin, Reinickendorfer Str. 61, 13347, Berlin, Germany.

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http://dx.doi.org/10.1007/s00391-015-0958-0DOI Listing
October 2015

Severe hypertriglyceridemia in a patient heterozygous for a lipoprotein lipase gene allele with two novel missense variants.

Eur J Hum Genet 2015 Sep 14;23(9):1259-61. Epub 2015 Jan 14.

1] The Berlin Aging Study II; Research Group on Geriatrics; Charité-Universitätsmedizin Berlin, Berlin, Germany [2] Institute of Medical and Human Genetics, Charité-Universitätsmedizin Berlin, Berlin, Germany.

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http://dx.doi.org/10.1038/ejhg.2014.295DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4538214PMC
September 2015

Directional dominance on stature and cognition in diverse human populations.

Authors:
Peter K Joshi Tonu Esko Hannele Mattsson Niina Eklund Ilaria Gandin Teresa Nutile Anne U Jackson Claudia Schurmann Albert V Smith Weihua Zhang Yukinori Okada Alena Stančáková Jessica D Faul Wei Zhao Traci M Bartz Maria Pina Concas Nora Franceschini Stefan Enroth Veronique Vitart Stella Trompet Xiuqing Guo Daniel I Chasman Jeffery R O'Connel Tanguy Corre Suraj S Nongmaithem Yuning Chen Massimo Mangino Daniela Ruggiero Michela Traglia Aliki-Eleni Farmaki Tim Kacprowski Andrew Bjonnes Ashley van der Spek Ying Wu Anil K Giri Lisa R Yanek Lihua Wang Edith Hofer Cornelius A Rietveld Olga McLeod Marilyn C Cornelis Cristian Pattaro Niek Verweij Clemens Baumbach Abdel Abdellaoui Helen R Warren Dragana Vuckovic Hao Mei Claude Bouchard John R B Perry Stefania Cappellani Saira S Mirza Miles C Benton Ulrich Broeckel Sarah E Medland Penelope A Lind Giovanni Malerba Alexander Drong Loic Yengo Lawrence F Bielak Degui Zhi Peter J van der Most Daniel Shriner Reedik Mägi Gibran Hemani Tugce Karaderi Zhaoming Wang Tian Liu Ilja Demuth Jing Hua Zhao Weihua Meng Lazaros Lataniotis Sander W van der Laan Jonathan P Bradfield Andrew R Wood Amelie Bonnefond Tarunveer S Ahluwalia Leanne M Hall Erika Salvi Seyhan Yazar Lisbeth Carstensen Hugoline G de Haan Mark Abney Uzma Afzal Matthew A Allison Najaf Amin Folkert W Asselbergs Stephan J L Bakker R Graham Barr Sebastian E Baumeister Daniel J Benjamin Sven Bergmann Eric Boerwinkle Erwin P Bottinger Archie Campbell Aravinda Chakravarti Yingleong Chan Stephen J Chanock Constance Chen Y-D Ida Chen Francis S Collins John Connell Adolfo Correa L Adrienne Cupples George Davey Smith Gail Davies Marcus Dörr Georg Ehret Stephen B Ellis Bjarke Feenstra Mary F Feitosa Ian Ford Caroline S Fox Timothy M Frayling Nele Friedrich Frank Geller Generation Scotland Irina Gillham-Nasenya Omri Gottesman Misa Graff Francine Grodstein Charles Gu Chris Haley Christopher J Hammond Sarah E Harris Tamara B Harris Nicholas D Hastie Nancy L Heard-Costa Kauko Heikkilä Lynne J Hocking Georg Homuth Jouke-Jan Hottenga Jinyan Huang Jennifer E Huffman Pirro G Hysi M Arfan Ikram Erik Ingelsson Anni Joensuu Åsa Johansson Pekka Jousilahti J Wouter Jukema Mika Kähönen Yoichiro Kamatani Stavroula Kanoni Shona M Kerr Nazir M Khan Philipp Koellinger Heikki A Koistinen Manraj K Kooner Michiaki Kubo Johanna Kuusisto Jari Lahti Lenore J Launer Rodney A Lea Benjamin Lehne Terho Lehtimäki David C M Liewald Lars Lind Marie Loh Marja-Liisa Lokki Stephanie J London Stephanie J Loomis Anu Loukola Yingchang Lu Thomas Lumley Annamari Lundqvist Satu Männistö Pedro Marques-Vidal Corrado Masciullo Angela Matchan Rasika A Mathias Koichi Matsuda James B Meigs Christa Meisinger Thomas Meitinger Cristina Menni Frank D Mentch Evelin Mihailov Lili Milani May E Montasser Grant W Montgomery Alanna Morrison Richard H Myers Rajiv Nadukuru Pau Navarro Mari Nelis Markku S Nieminen Ilja M Nolte George T O'Connor Adesola Ogunniyi Sandosh Padmanabhan Walter R Palmas James S Pankow Inga Patarcic Francesca Pavani Patricia A Peyser Kirsi Pietilainen Neil Poulter Inga Prokopenko Sarju Ralhan Paul Redmond Stephen S Rich Harri Rissanen Antonietta Robino Lynda M Rose Richard Rose Cinzia Sala Babatunde Salako Veikko Salomaa Antti-Pekka Sarin Richa Saxena Helena Schmidt Laura J Scott William R Scott Bengt Sennblad Sudha Seshadri Peter Sever Smeeta Shrestha Blair H Smith Jennifer A Smith Nicole Soranzo Nona Sotoodehnia Lorraine Southam Alice V Stanton Maria G Stathopoulou Konstantin Strauch Rona J Strawbridge Matthew J Suderman Nikhil Tandon Sian-Tsun Tang Kent D Taylor Bamidele O Tayo Anna Maria Töglhofer Maciej Tomaszewski Natalia Tšernikova Jaakko Tuomilehto Andre G Uitterlinden Dhananjay Vaidya Astrid van Hylckama Vlieg Jessica van Setten Tuula Vasankari Sailaja Vedantam Efthymia Vlachopoulou Diego Vozzi Eero Vuoksimaa Melanie Waldenberger Erin B Ware William Wentworth-Shields John B Whitfield Sarah Wild Gonneke Willemsen Chittaranjan S Yajnik Jie Yao Gianluigi Zaza Xiaofeng Zhu The BioBank Japan Project Rany M Salem Mads Melbye Hans Bisgaard Nilesh J Samani Daniele Cusi David A Mackey Richard S Cooper Philippe Froguel Gerard Pasterkamp Struan F A Grant Hakon Hakonarson Luigi Ferrucci Robert A Scott Andrew D Morris Colin N A Palmer George Dedoussis Panos Deloukas Lars Bertram Ulman Lindenberger Sonja I Berndt Cecilia M Lindgren Nicholas J Timpson Anke Tönjes Patricia B Munroe Thorkild I A Sørensen Charles N Rotimi Donna K Arnett Albertine J Oldehinkel Sharon L R Kardia Beverley Balkau Giovanni Gambaro Andrew P Morris Johan G Eriksson Margie J Wright Nicholas G Martin Steven C Hunt John M Starr Ian J Deary Lyn R Griffiths Henning Tiemeier Nicola Pirastu Jaakko Kaprio Nicholas J Wareham Louis Pérusse James G Wilson Giorgia Girotto Mark J Caulfield Olli Raitakari Dorret I Boomsma Christian Gieger Pim van der Harst Andrew A Hicks Peter Kraft Juha Sinisalo Paul Knekt Magnus Johannesson Patrik K E Magnusson Anders Hamsten Reinhold Schmidt Ingrid B Borecki Erkki Vartiainen Diane M Becker Dwaipayan Bharadwaj Karen L Mohlke Michael Boehnke Cornelia M van Duijn Dharambir K Sanghera Alexander Teumer Eleftheria Zeggini Andres Metspalu Paolo Gasparini Sheila Ulivi Carole Ober Daniela Toniolo Igor Rudan David J Porteous Marina Ciullo Tim D Spector Caroline Hayward Josée Dupuis Ruth J F Loos Alan F Wright Giriraj R Chandak Peter Vollenweider Alan Shuldiner Paul M Ridker Jerome I Rotter Naveed Sattar Ulf Gyllensten Kari E North Mario Pirastu Bruce M Psaty David R Weir Markku Laakso Vilmundur Gudnason Atsushi Takahashi John C Chambers Jaspal S Kooner David P Strachan Harry Campbell Joel N Hirschhorn Markus Perola Ozren Polašek James F Wilson

Nature 2015 Jul 1;523(7561):459-462. Epub 2015 Jul 1.

Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, Scotland.

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http://dx.doi.org/10.1038/nature14618DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4516141PMC
July 2015

Association of Low Lean Mass With Frailty and Physical Performance: A Comparison Between Two Operational Definitions of Sarcopenia-Data From the Berlin Aging Study II (BASE-II).

J Gerontol A Biol Sci Med Sci 2015 Jun 31;70(6):779-84. Epub 2015 Jan 31.

Charité Research Group on Geriatrics, Charité-Universitätsmedizin, Berlin, Germany.

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http://dx.doi.org/10.1093/gerona/glu246DOI Listing
June 2015

Clinical utility gene card for: hyperlipoproteinemia, TYPE II.

Eur J Hum Genet 2014 Jul 20;22(7). Epub 2013 Nov 20.

1] The Berlin Aging Study II, Research Group on Geriatrics, Charité-Universitätsmedizin Berlin, Reinickendorfer Str. 61, Berlin, Germany [2] Institute of Medical and Human Genetics, Charité-Universitätsmedizin Berlin, Augustenburger Platz 1, Berlin, Germany.

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http://dx.doi.org/10.1038/ejhg.2013.271DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4060121PMC
July 2014

MicroRNA-138 is a potential regulator of memory performance in humans.

Front Hum Neurosci 2014 11;8:501. Epub 2014 Jul 11.

Department of Vertebrate Genomics, Max Planck Institute for Molecular Genetics Berlin, Germany ; Faculty of Medicine, School of Public Health, Imperial College London London, UK.

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http://dx.doi.org/10.3389/fnhum.2014.00501DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4093940PMC
July 2014

Cohort profile: The Berlin Aging Study II (BASE-II).

Int J Epidemiol 2014 Jun 14;43(3):703-12. Epub 2013 Mar 14.

Department of Vertebrate Genomics, Max Planck Institute for Molecular Genetics, Berlin, Germany, German Socio-Economic Panel Study (SOEP), Deutsches Institut für Wirtschaftsforschung, Berlin, Germany, Charité Research Group on Geriatrics, Charité-Universitätsmedizin, Berlin, Germany, Institute of Medical and Human Genetics, Charité-Universitätsmedizin, Berlin, Germany, Center for Lifespan Psychology, Max Planck Institute for Human Development, Berlin, Germany, Department of Psychology, TU Dresden, Dresden, Germany, Center for Medical Research, University of Tübingen, Tübingen, Germany, Department of Economics, University of Hamburg, Hamburg, Germany and Berlin University of Technology (TUB), Berlin, Germany

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June 2014

DNA-repair in mild cognitive impairment and Alzheimer's disease.

DNA Repair (Amst) 2013 Oct 3;12(10):811-6. Epub 2013 Aug 3.

The Berlin Aging Study II; Research Group on Geriatrics; Charité - Universitätsmedizin Berlin, Berlin, Germany.

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http://dx.doi.org/10.1016/j.dnarep.2013.07.005DOI Listing
October 2013

The nuclease hSNM1B/Apollo is linked to the Fanconi anemia pathway via its interaction with FANCP/SLX4.

Hum Mol Genet 2012 Nov 19;21(22):4948-56. Epub 2012 Aug 19.

Institute of Medical and Human Genetics, Charité-Universitätsmedizin Berlin, Augustenburger Platz 1, Berlin, Germany.

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http://dx.doi.org/10.1093/hmg/dds338DOI Listing
November 2012

DNA damage in Nijmegen Breakage Syndrome cells leads to PARP hyperactivation and increased oxidative stress.

PLoS Genet 2012 1;8(3):e1002557. Epub 2012 Mar 1.

Institute of Medical and Human Genetics, Charité-Universitätsmedizin Berlin, Berlin, Germany.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3291567PMC
September 2012

Evidence for hSNM1B/Apollo functioning in the HSP70 mediated DNA damage response.

Cell Cycle 2009 Jun 1;8(11):1725-32. Epub 2009 Jun 1.

Institut für Humangenetik, Charité-Universitätsmedizin Berlin, Berlin, Germany.

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http://dx.doi.org/10.4161/cc.8.11.8605DOI Listing
June 2009

DNA repair 2008: Tenth Biennial Meeting of the German Society for Research on DNA Repair.

DNA Repair (Amst) 2009 Mar 30;8(3):424-8. Epub 2008 Dec 30.

Institut für Humangenetik, Charité-Universitätsmedizin Berlin, Berlin, Germany.

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March 2009

Endogenous hSNM1B/Apollo interacts with TRF2 and stimulates ATM in response to ionizing radiation.

DNA Repair (Amst) 2008 Aug 12;7(8):1192-201. Epub 2008 May 12.

Institut für Humangenetik, Charité - Universitätsmedizin Berlin, Campus Virchow Klinikum, Berlin, Germany.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2582150PMC
August 2008

Extreme variation in apoptosis capacity amongst lymphoid cells of Nijmegen breakage syndrome patients.

Eur J Cell Biol 2008 Feb 30;87(2):111-21. Epub 2007 Oct 30.

Institut für Humangenetik, Charité - Universitätsmedizin Berlin, Germany.

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February 2008

Cancer incidence in Nijmegen breakage syndrome is modulated by the amount of a variant NBS protein.

Carcinogenesis 2007 Jan 13;28(1):107-11. Epub 2006 Jul 13.

Institut für Humangenetik, Charité-Universitätsmedizin Berlin Campus-Virchow Klinikum, Augustenburger Platz 1, 13353 Berlin, Germany.

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January 2007

Selenium-binding protein 2, the major hepatic target for acetaminophen, shows sex differences in protein abundance.

Electrophoresis 2006 Apr;27(8):1683-91

Institute of Human Genetics, Charité, Berlin, Germany.

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April 2006

The Fanconi anemia group A protein modulates homologous repair of DNA double-strand breaks in mammalian cells.

Carcinogenesis 2005 Oct 19;26(10):1731-40. Epub 2005 May 19.

International Agency for Research on Cancer (IARC), 150 cours Albert Thomas, F-69008 Lyon, France.

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October 2005

An essential function for NBS1 in the prevention of ataxia and cerebellar defects.

Nat Med 2005 May 10;11(5):538-44. Epub 2005 Apr 10.

International Agency for Research on Cancer, Lyon, France.

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http://dx.doi.org/10.1038/nm1228DOI Listing
May 2005

Nibrin functions in Ig class-switch recombination.

Proc Natl Acad Sci U S A 2005 Feb 24;102(5):1584-9. Epub 2005 Jan 24.

German Rheumatism Research Center, Schumannstrasse 21-22, 10117 Berlin, Germany.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC547877PMC
February 2005

Human SNM1B is required for normal cellular response to both DNA interstrand crosslink-inducing agents and ionizing radiation.

Oncogene 2004 Nov;23(53):8611-8

Molecular Genetics Program, Benaroya Research Institute, Seattle, WA 98101-2795, USA.

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November 2004

An inducible null mutant murine model of Nijmegen breakage syndrome proves the essential function of NBS1 in chromosomal stability and cell viability.

Hum Mol Genet 2004 Oct 27;13(20):2385-97. Epub 2004 Aug 27.

Institut für Humangenetik, Charité Universitätsmedizin Berlin, Campus Virchow-Klinikum, Augustenburger Platz 1, 13353 Berlin, Germany.

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October 2004

Attenuation of the formation of DNA-repair foci containing RAD51 in Fanconi anaemia.

Carcinogenesis 2002 Jul;23(7):1121-6

Institut für Humangenetik, Charité-Campus Virchow-Klinikum, Humboldt Universität zu Berlin, Augustenburger Platz 1, 13353 Berlin, Germany.

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July 2002

SV40 large T-antigen disturbs the formation of nuclear DNA-repair foci containing MRE11.

Oncogene 2002 Jul;21(32):4873-8

Institut für Humangenetik, Charité - Campus Virchow-Klinikum, Humboldt Universität zu Berlin, Germany.

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http://dx.doi.org/10.1038/sj.onc.1205616DOI Listing
July 2002