Publications by authors named "Ilaria Genovese"

18Publications

Mitochondria as the decision makers for cancer cell fate: from signaling pathways to therapeutic strategies.

Authors:
Ilaria Genovese Bianca Vezzani Alberto Danese Lorenzo Modesti Veronica Angela Maria Vitto Virginia Corazzi Stefano Pelucchi Paolo Pinton Carlotta Giorgi

Cell Calcium 2020 Dec 16;92:102308. Epub 2020 Oct 16.

Department of Medical Sciences, Laboratory for Technologies of Advanced Therapies (LTTA), University of Ferrara, Ferrara, Italy. Electronic address:

View Article and Find Full Text PDF
December 2020

Sorcin is an early marker of neurodegeneration, Ca dysregulation and endoplasmic reticulum stress associated to neurodegenerative diseases.

Authors:
Ilaria Genovese Flavia Giamogante Lucia Barazzuol Theo Battista Annarita Fiorillo Mattia Vicario Giuseppina D'Alessandro Raffaela Cipriani Cristina Limatola Daniela Rossi Vincenzo Sorrentino Elena Poser Luciana Mosca Ferdinando Squitieri Marzia Perluigi Andrea Arena Filip van Petegem Claudia Tito Francesco Fazi Carlotta Giorgi Tito Calì Andrea Ilari Gianni Colotti

Cell Death Dis 2020 10 15;11(10):861. Epub 2020 Oct 15.

Institute of Molecular Biology and Pathology, Italian National Research Council, IBPM-CNR, Rome, Italy.

View Article and Find Full Text PDF
October 2020

Cancer metabolism and mitochondria: Finding novel mechanisms to fight tumours.

Authors:
Sonia Missiroli Mariasole Perrone Ilaria Genovese Paolo Pinton Carlotta Giorgi

EBioMedicine 2020 Sep 17;59:102943. Epub 2020 Aug 17.

Department of Medical Sciences, Laboratory for Technologies of Advanced Therapies (LTTA), University of Ferrara, Ferrara, Italy. Electronic address:

View Article and Find Full Text PDF
September 2020

Profiling calcium-dependent interactions between Sorcin and intrinsically disordered regions of human proteome.

Authors:
Ilaria Genovese Andrea Carotti Andrea Ilari Annarita Fiorillo Theo Battista Gianni Colotti Ylva Ivarsson

Biochim Biophys Acta Gen Subj 2020 08 17;1864(8):129618. Epub 2020 Apr 17.

Department of Chemistry - BMC, Uppsala University, Husargatan 3, 751 23 Uppsala, Sweden.

View Article and Find Full Text PDF
August 2020

Exogenous peptides are able to penetrate human cell and mitochondrial membranes, stabilize mitochondrial tRNA structures, and rescue severe mitochondrial defects.

Authors:
Elena Perli Annalinda Pisano Maria Gemma Pignataro Antonio Francesco Campese Maria Pelullo Ilaria Genovese Valeria de Turris Anna Maria Ghelli Bruna Cerbelli Carla Giordano Gianni Colotti Veronica Morea Giulia d'Amati

FASEB J 2020 06 18;34(6):7675-7686. Epub 2020 Apr 18.

Laboratory affiliated to Istituto Pasteur Italia-Fondazione Cenci Bolognetti, Department of Radiological, Oncological and Pathological Sciences, Sapienza University of Rome, Rome, Italy.

View Article and Find Full Text PDF
June 2020

Roles of Sorcin in Drug Resistance in Cancer: One Protein, Many Mechanisms, for a Novel Potential Anticancer Drug Target.

Authors:
Theo Battista Annarita Fiorillo Valerio Chiarini Ilaria Genovese Andrea Ilari Gianni Colotti

Cancers (Basel) 2020 Apr 6;12(4). Epub 2020 Apr 6.

Institute of Molecular Biology and Pathology, Italian National Research Council, Istituto di Biologia e Patologia Molecolari, Consiglio Nazionale delle Ricerche (IBPM-CNR), c/o Department of Biochemical Sciences, Sapienza University, P.le A.Moro 5, 00185 Rome, Italy.

View Article and Find Full Text PDF
April 2020

The Role of Mitochondria in Inflammation: From Cancer to Neurodegenerative Disorders.

Authors:
Sonia Missiroli Ilaria Genovese Mariasole Perrone Bianca Vezzani Veronica A M Vitto Carlotta Giorgi

J Clin Med 2020 Mar 9;9(3). Epub 2020 Mar 9.

Department of Morphology, Surgery and Experimental Medicine, Section of Pathology, Oncology and Experimental Biology, Laboratory for Technologies of Advanced Therapies (LTTA), University of Ferrara, 44121 Ferrara, Italy.

View Article and Find Full Text PDF
March 2020

The role of mitochondria-associated membranes in cellular homeostasis and diseases.

Authors:
Mariasole Perrone Natascia Caroccia Ilaria Genovese Sonia Missiroli Lorenzo Modesti Gaia Pedriali Bianca Vezzani Veronica Angela Maria Vitto Michele Antenori Magdalena Lebiedzinska-Arciszewska Mariusz R Wieckowski Carlotta Giorgi Paolo Pinton

Int Rev Cell Mol Biol 2020 3;350:119-196. Epub 2019 Dec 3.

Department of Morphology, Surgery and Experimental Medicine, Section of Pathology, Oncology and Experimental Biology, Laboratory for Technologies of Advanced Therapies (LTTA), University of Ferrara, Ferrara, Italy; Maria Cecilia Hospital, GVM Care & Research, Cotignola (RA), Italy. Electronic address:

View Article and Find Full Text PDF
December 2020

Identification and binding mode of a novel Leishmania Trypanothione reductase inhibitor from high throughput screening.

Authors:
Lorenzo Turcano Esther Torrente Antonino Missineo Matteo Andreini Marina Gramiccia Trentina Di Muccio Ilaria Genovese Annarita Fiorillo Steven Harper Alberto Bresciani Gianni Colotti Andrea Ilari

PLoS Negl Trop Dis 2018 11 26;12(11):e0006969. Epub 2018 Nov 26.

Istituto di Biologia e Patologia Molecolari-CNR, and Dipartimento di Scienze Biochimiche, "Sapienza" Università di Roma P.le A. Moro, Roma, Italy.

View Article and Find Full Text PDF
November 2018

Toward a Drug Against All Kinetoplastids: From LeishBox to Specific and Potent Trypanothione Reductase Inhibitors.

Authors:
Andrea Ilari Ilaria Genovese Fabiana Fiorillo Theo Battista Ilenia De Ionna Annarita Fiorillo Gianni Colotti

Mol Pharm 2018 08 27;15(8):3069-3078. Epub 2018 Jun 27.

Institute of Molecular Biology and Pathology, Italian National Research Council (IBPM CNR), Department of Biochemical Sciences , Sapienza University , P.le A. Moro 5 , 00185 Rome , Italy.

View Article and Find Full Text PDF
August 2018

Not only P-glycoprotein: Amplification of the ABCB1-containing chromosome region 7q21 confers multidrug resistance upon cancer cells by coordinated overexpression of an assortment of resistance-related proteins.

Authors:
Ilaria Genovese Andrea Ilari Yehuda G Assaraf Francesco Fazi Gianni Colotti

Drug Resist Updat 2017 05 16;32:23-46. Epub 2017 Oct 16.

Institute of Molecular Biology and Pathology, Italian National Research Council (IBPM-CNR), c/o Dept. Biochemical Sciences, Sapienza University, P.le A. Moro 5, 00185 Rome, Italy. Electronic address:

View Article and Find Full Text PDF
May 2017

Binding of doxorubicin to Sorcin impairs cell death and increases drug resistance in cancer cells.

Authors:
Ilaria Genovese Annarita Fiorillo Andrea Ilari Silvia Masciarelli Francesco Fazi Gianni Colotti

Cell Death Dis 2017 07 20;8(7):e2950. Epub 2017 Jul 20.

IBPM-CNR Institute of Molecular Biology and Pathology, Italian National Research Council, Rome, Italy.

View Article and Find Full Text PDF
July 2017

Polyamine-trypanothione pathway: an update.

Authors:
Andrea Ilari Annarita Fiorillo Ilaria Genovese Gianni Colotti

Future Med Chem 2017 01 13;9(1):61-77. Epub 2016 Dec 13.

CNR - National Research Council of Italy, Institute of Molecular Biology & Pathology, c/o Department of Biochemical Sciences "A. Rossi Fanelli", University Sapienza, P.le Aldo Moro 5, 00185 - Rome, Italy.

View Article and Find Full Text PDF
January 2017

Surface Plasmon Resonance: A Useful Strategy for the Identification of Small Molecule Argonaute 2 Protein Binders.

Authors:
Elena Poser Ilaria Genovese Silvia Masciarelli Teresa Bellissimo Francesco Fazi Gianni Colotti

Methods Mol Biol 2017 ;1517:223-237

IBPM - CNR Institute of Molecular Biology and Pathology, Italian National Research Council, Department of Biochemical Sciences "A. Rossi Fanelli", Sapienza University of Rome, P.le A. Moro 5, 00185, Rome, Italy.

View Article and Find Full Text PDF
January 2018

Small Molecules Targeting the miRNA-Binding Domain of Argonaute 2: From Computer-Aided Molecular Design to RNA Immunoprecipitation.

Authors:
Teresa Bellissimo Silvia Masciarelli Elena Poser Ilaria Genovese Alberto Del Rio Gianni Colotti Francesco Fazi

Methods Mol Biol 2017 ;1517:211-221

Department of Anatomical, Histological, Forensic & Orthopaedic Sciences, Section of Histology & Medical Embryology, Sapienza University of Rome, Via A. Scarpa, 14-16, 00161, Rome, Italy.

View Article and Find Full Text PDF
January 2018

Short peptides from leucyl-tRNA synthetase rescue disease-causing mitochondrial tRNA point mutations.

Authors:
Elena Perli Annarita Fiorillo Carla Giordano Annalinda Pisano Arianna Montanari Paola Grazioli Antonio F Campese Patrizio Di Micco Helen A Tuppen Ilaria Genovese Elena Poser Carmela Preziuso Robert W Taylor Veronica Morea Gianni Colotti Giulia d'Amati

Hum Mol Genet 2016 Mar 31;25(5):903-15. Epub 2015 Dec 31.

Department of Radiology, Oncology and Pathology, Pasteur Institute-Cenci Bolognetti Foundation, Rome 00161, Italy,

View Article and Find Full Text PDF
March 2016

Structural basis of Sorcin-mediated calcium-dependent signal transduction.

Authors:
Andrea Ilari Annarita Fiorillo Elena Poser Vasiliki S Lalioti Gustav N Sundell Ylva Ivarsson Ilaria Genovese Gianni Colotti

Sci Rep 2015 Nov 18;5:16828. Epub 2015 Nov 18.

Institute of Molecular Biology and Pathology CNR; Dept. Biochemical Sciences, Sapienza University, P.le A. Moro 5, 00185, Rome, Italy.

View Article and Find Full Text PDF
November 2015

Sorcin, a calcium binding protein involved in the multidrug resistance mechanisms in cancer cells.

Authors:
Gianni Colotti Elena Poser Annarita Fiorillo Ilaria Genovese Valerio Chiarini Andrea Ilari

Molecules 2014 Sep 5;19(9):13976-89. Epub 2014 Sep 5.

Institute of Biology, Molecular Medicine and Nanobiotechnology, Consiglio Nazionale delle Ricerche, P.le A Moro 5, Rome 00185, Italy.

View Article and Find Full Text PDF
September 2014