Ilaria Dalla Rosa

Ilaria Dalla Rosa

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Ilaria Dalla Rosa

Ilaria Dalla Rosa

Publications by authors named "Ilaria Dalla Rosa"

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Beyond the unwinding: role of TOP1MT in mitochondrial translation.

Cell Cycle 2019 Oct 9;18(19):2377-2384. Epub 2019 Aug 9.

Laboratory of Molecular Pharmacology, Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, NIH , Bethesda , MD , USA.

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http://dx.doi.org/10.1080/15384101.2019.1646563DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6739053PMC
October 2019

Transcription profiling suggests that mitochondrial topoisomerase IB acts as a topological barrier and regulator of mitochondrial DNA transcription.

J Biol Chem 2017 12 11;292(49):20162-20172. Epub 2017 Oct 11.

From the Laboratory of Molecular Pharmacology, Developmental Therapeutics Branch, Center for Cancer Research, NCI, National Institutes of Health, Bethesda, Maryland 20892 and

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http://dx.doi.org/10.1074/jbc.M117.815241DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5724003PMC
December 2017

Lack of mitochondrial topoisomerase I (TOP1mt) impairs liver regeneration.

Proc Natl Acad Sci U S A 2015 Sep 24;112(36):11282-7. Epub 2015 Aug 24.

Developmental Therapeutics Branch, Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892;

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http://dx.doi.org/10.1073/pnas.1511016112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4568654PMC
September 2015

Mitochondrial topoisomerase I (top1mt) is a novel limiting factor of doxorubicin cardiotoxicity.

Clin Cancer Res 2014 Sep 8;20(18):4873-81. Epub 2014 Apr 8.

Developmental Therapeutics Branch and Laboratory of Molecular Pharmacology;

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http://dx.doi.org/10.1158/1078-0432.CCR-13-3373DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4167185PMC
September 2014

Poisoning of mitochondrial topoisomerase I by lamellarin D.

Mol Pharmacol 2014 Aug 2;86(2):193-9. Epub 2014 Jun 2.

Developmental Therapeutics Branch and Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute (S.K., K.A., I.D.R., S.A., K.F., H.Z., Y.P.) and Laboratory of Molecular Biophysics, National Heart, Lung, and Blood Institute (Y.S., K.C.N.), National Institutes of Health, Bethesda, Maryland

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http://dx.doi.org/10.1124/mol.114.092833DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4127927PMC
August 2014

Mapping topoisomerase sites in mitochondrial DNA with a poisonous mitochondrial topoisomerase I (Top1mt).

J Biol Chem 2014 Jun 5;289(26):18595-602. Epub 2014 May 5.

From the Laboratory of Molecular Pharmacology, Developmental Therapeutics Branch, Center for Cancer Research, NCI, National Institutes of Health, Bethesda, Maryland 20892

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http://dx.doi.org/10.1074/jbc.M114.555367DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4140277PMC
June 2014

Increased negative supercoiling of mtDNA in TOP1mt knockout mice and presence of topoisomerases IIα and IIβ in vertebrate mitochondria.

Nucleic Acids Res 2014 Jun 6;42(11):7259-67. Epub 2014 May 6.

Laboratory of Molecular Pharmacology and Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-4255, USA

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http://nar.oxfordjournals.org/content/42/11/7259.full.pdf
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http://nar.oxfordjournals.org/lookup/doi/10.1093/nar/gku384
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http://dx.doi.org/10.1093/nar/gku384DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4066791PMC
June 2014

Negative regulation of mitochondrial transcription by mitochondrial topoisomerase I.

Nucleic Acids Res 2013 Nov 27;41(21):9848-57. Epub 2013 Aug 27.

Institute of Clinical Chemistry and Laboratory Diagnostics, Heinrich-Heine-University, Med. Faculty, D-40225 Düsseldorf, Germany, Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA, Center for Physiology and Pathophysiology, Institute of Vegetative Physiology, University of Köln, D-50931 Köln, Germany, Center for Molecular Medicine Cologne, University of Köln, D-50931 Köln, Germany, Cologne Excellence Cluster on Cellular Stress Responses in Aging-associated Diseases, University of Köln, D-50931 Köln, Germany, Department of Pediatrics, Med. Faculty, University of Köln, D-50931 Köln, Germany and Center for Microbiology and Virology, Institute of Virology, Heinrich-Heine-University, Med. Faculty, D-40225 Düsseldorf, Germany.

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http://dx.doi.org/10.1093/nar/gkt768DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3834834PMC
November 2013

TDP1 repairs nuclear and mitochondrial DNA damage induced by chain-terminating anticancer and antiviral nucleoside analogs.

Nucleic Acids Res 2013 Sep 17;41(16):7793-803. Epub 2013 Jun 17.

Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA, Department of Radiation Genetics, Kyoto University Graduate School of Medicine, Yoshida Konoe, Sakyo-ku, Kyoto 606-8501, Japan, NIH Chemical Genomics Center, National Center for Advancing Translational Sciences, NIH, Rockville, MD 20850, USA and Department of Cancer Biology, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA.

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http://dx.doi.org/10.1093/nar/gkt483DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3763526PMC
September 2013

Mitochondrial topoisomerase I is critical for mitochondrial integrity and cellular energy metabolism.

PLoS One 2012 20;7(7):e41094. Epub 2012 Jul 20.

Laboratory of Molecular Pharmacology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0041094PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3401127PMC
April 2013

XRCC4 controls nuclear import and distribution of Ligase IV and exchanges faster at damaged DNA in complex with Ligase IV.

DNA Repair (Amst) 2011 Dec 5;10(12):1232-42. Epub 2011 Oct 5.

Institute of Clinical Chemistry and Laboratory Diagnostics, Univ Düsseldorf, Medical Faculty, D-40225 Düsseldorf, Germany.

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http://dx.doi.org/10.1016/j.dnarep.2011.09.012DOI Listing
December 2011

Coordinated regulation of mitochondrial topoisomerase IB with mitochondrial nuclear encoded genes and MYC.

Nucleic Acids Res 2011 Aug 29;39(15):6620-32. Epub 2011 Apr 29.

Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20890, USA.

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http://dx.doi.org/10.1093/nar/gkr208DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3159436PMC
August 2011

53BP1 and MDC1 foci formation in HT-1080 cells for low- and high-LET microbeam irradiations.

Radiat Environ Biophys 2011 Aug 11;50(3):345-52. Epub 2011 May 11.

Physikalisch-Technische Bundesanstalt (PTB), Bundesallee 100, 38116, Braunschweig, Germany.

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http://dx.doi.org/10.1007/s00411-011-0366-9DOI Listing
August 2011

Adaptation of topoisomerase I paralogs to nuclear and mitochondrial DNA.

Nucleic Acids Res 2009 Oct 31;37(19):6414-28. Epub 2009 Aug 31.

Institute of Clinical Chemistry and Laboratory Diagnostics, Heinrich-Heine-University, Medical School, D-40225 Düsseldorf, Germany.

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http://dx.doi.org/10.1093/nar/gkp708DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2770673PMC
October 2009