Dr. Ikuo Tsunoda, MD, PhD - Kindai University Faculty of Medicine - Professor and Chair

Dr. Ikuo Tsunoda

MD, PhD

Kindai University Faculty of Medicine

Professor and Chair

Osakasayama, Osaka | Japan

Main Specialties: Neuropathology

Additional Specialties: multiple sclerosis, EAE, TMEV, myocarditis

ORCID logohttps://orcid.org/0000-0003-1798-714X


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Dr. Ikuo Tsunoda, MD, PhD - Kindai University Faculty of Medicine - Professor and Chair

Dr. Ikuo Tsunoda

MD, PhD

Introduction

Ikuo Tsunoda was born in Fukushima, Japan. He obtained his MD and PhD degrees from Tohoku University School of Medicine, Sendai, Japan. His thesis was immunopathological studies on a viral model for multiple sclerosis (MS), Theiler’s murine encephalomyelitis virus (TMEV) infection. Thereafter, He continued to conduct research on MS as a Research Associate (Junior Faculty, "Joshu") at the Department of Neurological Sciences (Neuropathology), Tohoku University School of Medicine for one year. While in Japan, he trained as a Neurology resident for two years under Teiji Yamamoto, MD, Professor, Department of Neurology, Fukushima Medical University, Fukushima. He also trained in human neuropathology under Yuzo Iwasaki, MD, PhD,

Full-time Positions
1994 Research Associate, Department of Neurological Sciences, Tohoku University School of Medicine, Sendai, Japan
1999-2002 Research Associate, Department of Neurology, University of Utah School of Medicine, Salt Lake City, Utah
2002-2005 Instructor, Department of Neurology, University of Utah School of Medicine, Salt Lake City, Utah
2005-2007 Assistant Professor, Department of Neurology, University of Utah School of Medicine, Salt Lake City, Utah
2007-2009 Research Assistant Professor, Department of Pathology, Division of Cell Biology & Immunology, University of Utah School of Medicine, Salt Lake City, Utah
2008-2009 Adjunct Assistant Professor, Department of Neurology, University of Utah School of Medicine, Salt Lake City, Utah
2009-2015 Assistant Professor, Department of Microbiology and Immunology, Louisiana State University Health Sciences Center, Shreveport, Louisiana
2015-2016 Associate Professor, Department of Microbiology and Immunology, Adjunct Associate Professor, Department of Neurology, Louisiana State University Health Sciences Center, Shreveport, Louisiana
2016-present Professor and Chair, Department of Microbiology, Kindai University Faculty of Medicine, Osakasayama, Osaka, Japan

Primary Affiliation: Kindai University Faculty of Medicine - Osakasayama, Osaka , Japan

Specialties:

Additional Specialties:

Research Interests:


View Dr. Ikuo Tsunoda’s Resume / CV

Education

Apr 1995
University of Utah School of Medicine
Postdoctoral Fellow
Neurology, Neuroimmunology, Neurovirology
Apr 1990 - Mar 1994
Tohoku University
PhD
Neurological Sciences
Mar 1994
Tohoku University School of Medicine
PhD
Neuropathology
Mar 1990
Tohoku University School of Medicine
MD
General Medicine

Experience

Sep 2016
Councilor

Japanese Society for Neuroimmunology
Apr 2016
Advisory Board Member

Japan Multiple Sclerosis Society (JMSS)
Jul 2015 - Mar 2016
Louisiana State University Health Sciences Center Shreveport
Associate Professor
Microbiology and Immunology
Jul 2009 - Jun 2015
Louisiana State University Health Sciences Center Shreveport
Assistant Professor
Microbiology and Immunology
Jan 2014
Editorial Board Member
Associate Editor, Demyelinating diseases
BMC Neurology
Jan 1995 - Jun 2009
University of Utah
Assistant Professor
Pathology
Apr 1994 - Dec 1994
Tohoku Daigaku
Research Associate/joshu
Neurological Sciences
Apr 2016
Kindai University Faculty of Medicine
Professor/Chair MD, PhD
Microbiology

Publications

75Publications

733Reads

951Profile Views

628PubMed Central Citations

IL-1β reduces cardiac lymphatic muscle contraction via COX-2 and PGE induction: Potential role in myocarditis.

Biomed Pharmacother 2018 Nov 6;107:1591-1600. Epub 2018 Sep 6.

Department of Molecular & Cellular Physiology, United States; Department of Neurology, Louisiana State University Health Sciences Center-Shreveport, LA, United States. Electronic address:

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http://dx.doi.org/10.1016/j.biopha.2018.08.004DOI Listing
November 2018
5 Reads
2.023 Impact Factor

Heat shock protein 27 promotes cell cycle progression by down-regulating E2F transcription factor 4 and retinoblastoma family protein p130.

J Biol Chem 2018 10 30;293(41):15815-15826. Epub 2018 Aug 30.

From the Department of Microbiology, Kindai University Faculty of Medicine, Osakasayama, Osaka 589-8511, Japan and.

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http://dx.doi.org/10.1074/jbc.RA118.003310DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6187643PMC
October 2018
7 Reads
4.573 Impact Factor

Forensic luminol reaction for detecting fecal occult blood in experimental mice.

Biotechniques 2018 10 24;65(4):227-230. Epub 2018 Aug 24.

Department of Microbiology, Kindai University Faculty of Medicine, Osakasayama, Osaka 589-8511, Japan.

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http://dx.doi.org/10.2144/btn-2018-0017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6353634PMC
October 2018
6 Reads
2.950 Impact Factor

Metallothionein I as a direct link between therapeutic hematopoietic stem/progenitor cells and cerebral protection in stroke.

FASEB J 2018 05 21;32(5):2381-2394. Epub 2017 Dec 21.

Department of Molecular and Cellular Physiology, Louisiana State University Health Sciences Center-Shreveport, Shreveport, Louisiana, USA.

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http://dx.doi.org/10.1096/fj.201700746RDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5901383PMC
May 2018
10 Reads
5.043 Impact Factor

Murine γ-Herpesvirus 68 Induces Severe Lung Inflammation in IL-27-Deficient Mice with Liver Dysfunction Preventable by Oral Neomycin.

J Immunol 2018 04 2;200(8):2703-2713. Epub 2018 Mar 2.

Department of Microbiology, Kindai University Faculty of Medicine, Osaka-Sayama, Osaka 589-8511, Japan;

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http://dx.doi.org/10.4049/jimmunol.1700412DOI Listing
April 2018
15 Reads
4.922 Impact Factor

CCL28-Deficient Mice Have Reduced IgA Antibody-Secreting Cells and an Altered Microbiota in the Colon.

J Immunol 2018 01 13;200(2):800-809. Epub 2017 Dec 13.

Department of Microbiology, Kindai University Faculty of Medicine, Osakasayama, Osaka 589-8511, Japan; and.

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http://dx.doi.org/10.4049/jimmunol.1700037DOI Listing
January 2018
7 Reads
2 Citations
4.922 Impact Factor

T-bet, but not Gata3, overexpression is detrimental in a neurotropic viral infection.

Sci Rep 2017 09 5;7(1):10496. Epub 2017 Sep 5.

Department of Microbiology, Kindai University Faculty of Medicine, 377-2 Ohnohigashi, Osakasayama, Osaka 589-8511, Japan.

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http://dx.doi.org/10.1038/s41598-017-10980-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5585213PMC
September 2017
11 Reads
5.080 Impact Factor

and gut microbiota in multiple sclerosis versus Alzheimer's disease: 10 pitfalls of microbiome studies.

Clin Exp Neuroimmunol 2017 Aug 23;8(3):215-232. Epub 2017 Jul 23.

Department of Microbiology, Kindai University Faculty of Medicine, 377-2 Ohnohigashi, Osakasayama, Osaka 589-8511, Japan.

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http://dx.doi.org/10.1111/cen3.12401DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5693366PMC
August 2017
15 Reads
3 Citations

IL-35 Suppresses Lipopolysaccharide-Induced Airway Eosinophilia in EBI3-Deficient Mice.

J Immunol 2017 01 23;198(1):119-127. Epub 2016 Nov 23.

Department of Microbiology, Kindai University Faculty of Medicine, Osaka 589-8511, Japan; and

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http://dx.doi.org/10.4049/jimmunol.1600506DOI Listing
January 2017
13 Reads
5 Citations
4.922 Impact Factor

From trash to treasure: The untapped potential of endothelial microparticles in neurovascular diseases.

Pathophysiology 2016 Dec 12;23(4):265-274. Epub 2016 Aug 12.

Departments of Molecular & Cellular Physiology, LSU Health Sciences Center, Shreveport, LA, United States; Departments of Neurology, LSU Health Sciences Center, Shreveport, LA, United States. Electronic address:

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http://dx.doi.org/10.1016/j.pathophys.2016.08.004DOI Listing
December 2016
22 Reads
1 Citation

Neuropathogenesis of Zika Virus Infection : Potential Roles of Antibody-Mediated Pathology

Acta Med Kinki Univ. 2016;41(2):37-52.

Acta Medica Kindai University

Zika virus (ZIKV) is an enveloped, positive-sense, single-stranded RNA virus that belongs to the genus Flavivirus, family Flaviviridae, which includes many human and animal pathogens, such as dengue virus (DENV) and West Nile virus. In the first original as well as following experimental and clinical reports, ZIKV seems to have moderate neurotropism (in animal models) and neurovirulence (in human fetuses), but no neuroinvasiveness (in human adults). Direct ZIKV infection (viral pathology) in fetal brains has been linked to increased incidence of microcephaly, while increased Guillain-Barré syndrome (GBS) following ZIKV is likely immune-mediated (immunopathology). Clinically, in ZIKV infection, antibodies against other flaviviruses, such as DENV, have been detected, while such antibodies can cross-react with ZIKV without ZIKV neutralization. In theory, such non-neutralizing antibodies are generated at the expense of decreased production of neutralizing antibody (“antigenic sin”), leading to poor viral clearance, while the non-neutralizing antibodies can also enhance viral replication in Fc receptor (FcR) positive cells via antibody-dependent enhancement (ADE) of infection. We here propose three potential roles of antibody-mediated pathogenesis of ZIKV infection: 1) cross-reactive antibodies that recognize ZIKV and neural antigens cause GBS; 2) the virus-antibody complex is transported transplacentally via neonatal FcR (FcRn), resulting in fetal infection; and 3) the ZIKV-antibody complex is taken up at the nerve ending in the periphery and transported to the cell body of neuron in the central nervous system (CNS), by which the virus can enter the CNS without crossing the blood-brain barrier.

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December 2016
14 Reads

Three immune-mediated disease models induced by Theiler's virus: Multiple sclerosis, seizures and myocarditis.

Clin Exp Neuroimmunol 2016 Nov 25;7(4):330-345. Epub 2016 Oct 25.

Department of Microbiology, Kindai University Faculty of Medicine, Osakasayama, Osaka, Japan.

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http://dx.doi.org/10.1111/cen3.12341DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5464738PMC
November 2016
14 Reads
1 Citation

A Critical Role for Monocytes/Macrophages During Intestinal Inflammation-associated Lymphangiogenesis.

Inflamm Bowel Dis 2016 06;22(6):1326-45

*Department of Molecular & Cellular Physiology, Louisiana State University Health Sciences Center-Shreveport, Shreveport, Louisiana; †Department of General and Visceral Surgery, University Hospital Muenster, Germany; ‡Department of Medicine, Center of Excellence for Arthritis and Rheumatology, Louisiana State University Health Sciences Center-Shreveport, Louisiana; Departments of §Neurology, ‖Microbiology and Immunology, ¶Cellular Biology and Anatomy; and **Pathology, Louisiana State University Health Sciences Center-Shreveport, Shreveport, Louisiana.

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http://dx.doi.org/10.1097/MIB.0000000000000731DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4912566PMC
June 2016
19 Reads
2 Citations
4.464 Impact Factor

Anti-Yo antibody uptake and interaction with its intracellular target antigen causes Purkinje cell death in rat cerebellar slice cultures: a possible mechanism for paraneoplastic cerebellar degeneration in humans with gynecological or breast cancers.

PLoS One 2015 17;10(4):e0123446. Epub 2015 Apr 17.

Department of Neurology, University of Utah School of Medicine, Salt Lake City, Utah, United States of America; Geriatric Research, Education, and Care Center (GRECC), George E. Wahlen Veterans Affairs Health Care System, Salt Lake City, Utah, United States of America; Research Service, George E. Wahlen Veterans Affairs Health Care System, Salt Lake City, Utah, United States of America; Department of Neurobiology and Anatomy, University of Utah School of Medicine, Salt Lake City, Utah, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0123446PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4401511PMC
January 2016
13 Reads
8 Citations
3.234 Impact Factor

Neuropathogenesis of Zika Virus Infection : Potential Roles of Antibody-Mediated Pathology.

Acta Med Kinki Univ 2016 ;41(2):37-52

Center for Drug Design Research, National Institutes of Biomedical Innovation, Health and Nutrition (NIBIOHN), Ibaraki, Osaka 567-0085, Japan.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5395253PMC
January 2016
9 Reads
5 Citations

"Microglial nodules" and "newly forming lesions" may be a Janus face of early MS lesions; implications from virus-induced demyelination, the Inside-Out model.

BMC Neurol 2015 Oct 24;15:219. Epub 2015 Oct 24.

Department of Microbiology and Immunology, Louisiana State University Health Sciences Center, 1501 Kings Highway, Shreveport, LA, 71130, USA.

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http://dx.doi.org/10.1186/s12883-015-0478-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4619492PMC
October 2015
8 Reads
5 Citations
2.040 Impact Factor

Downregulation of FoxC2 Increased Susceptibility to Experimental Colitis: Influence of Lymphatic Drainage Function?

Inflamm Bowel Dis 2015 Jun;21(6):1282-96

*Department of Molecular and Cellular Physiology, Louisiana State University Health Sciences Center Shreveport, Shreveport, Louisiana; †Department for General and Visceral Surgery, University of Münster, Münster, Germany; ‡Department of Medicine, Louisiana State University Health Sciences Center Shreveport, Shreveport, Louisiana; §Department of Surgery, University of Arizona, Tucson, Arizona; Departments of ‖Pathology, ¶Cellular Biology and Anatomy, and **Microbiology and Immunology, Louisiana State University Health Sciences Center Shreveport, Shreveport, Louisiana.

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http://dx.doi.org/10.1097/MIB.0000000000000371DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4437831PMC
June 2015
8 Reads
7 Citations
4.464 Impact Factor

Th17-biased RORγt transgenic mice become susceptible to a viral model for multiple sclerosis.

Brain Behav Immun 2015 Jan 18;43:86-97. Epub 2014 Jul 18.

Department of Microbiology and Immunology, Center for Molecular and Tumor Virology, Louisiana State University Health Sciences Center, Shreveport, LA 71130, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bbi.2014.07.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4258441PMC
January 2015
21 Reads
7 Citations
5.890 Impact Factor

Organ-specific protective role of NKT cells in virus-induced inflammatory demyelination and myocarditis depends on mouse strain.

J Neuroimmunol 2015 Jan 8;278:174-84. Epub 2014 Nov 8.

Department of Microbiology and Immunology, Louisiana State University Health Sciences Center, 1501 Kings Highway, Shreveport, LA 71130, USA; Center for Molecular and Tumor Virology, Louisiana State University Health Sciences Center, 1501 Kings Highway, Shreveport, LA 71130, USA; Center for Cardiovascular Diseases and Sciences, Louisiana State University Health Sciences Center, 1501 Kings Highway, Shreveport, LA 71130, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jneuroim.2014.11.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4297752PMC
January 2015
22 Reads
3 Citations
2.470 Impact Factor

RORγt, but not T-bet, overexpression exacerbates an autoimmune model for multiple sclerosis.

J Neuroimmunol 2014 Nov 16;276(1-2):142-9. Epub 2014 Sep 16.

Department of Microbiology and Immunology, Center for Molecular and Tumor Virology, Louisiana State University Health Sciences Center, Shreveport, LA 71130, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jneuroim.2014.09.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4252371PMC
November 2014
18 Reads
5 Citations
2.470 Impact Factor

Protective and detrimental roles for regulatory T cells in a viral model for multiple sclerosis.

Brain Pathol 2014 Sep 25;24(5):436-51. Epub 2014 Feb 25.

Department of Microbiology and Immunology, Center for Molecular and Tumor Virology, Louisiana State University Health Sciences Center, Shreveport, LA.

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http://dx.doi.org/10.1111/bpa.12119DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4097993PMC
September 2014
28 Reads
12 Citations
3.840 Impact Factor

Bioinformatics multivariate analysis determined a set of phase-specific biomarker candidates in a novel mouse model for viral myocarditis.

Circ Cardiovasc Genet 2014 Aug 16;7(4):444-54. Epub 2014 Jul 16.

From the Departments of Microbiology and Immunology (S.O., E.K., F.S., N.E.M., I.T.) and Molecular and Cellular Physiology (G.V.C., J.S.A.), Louisiana State University Health Sciences Center, Shreveport; and Department of Computer Science, Louisiana State University Shreveport (P.A.R., U.C., M.T.).

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http://dx.doi.org/10.1161/CIRCGENETICS.114.000505DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4332820PMC
August 2014
25 Reads
12 Citations
5.340 Impact Factor

Regulation of an autoimmune model for multiple sclerosis in Th2-biased GATA3 transgenic mice.

Int J Mol Sci 2014 Jan 23;15(2):1700-18. Epub 2014 Jan 23.

Department of Microbiology and Immunology, Center for Tumor and Molecular Virology, Louisiana State University Health Sciences Center, Shreveport, LA 71130, USA.

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http://dx.doi.org/10.3390/ijms15021700DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3958817PMC
January 2014
9 Reads
11 Citations
2.862 Impact Factor

Resveratrol exacerbates both autoimmune and viral models of multiple sclerosis.

Am J Pathol 2013 Nov 1;183(5):1390-1396. Epub 2013 Oct 1.

Department of Microbiology and Immunology, Center for Molecular and Tumor Virology, Louisiana State University Health Sciences Center, Shreveport, Louisiana. Electronic address:

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http://dx.doi.org/10.1016/j.ajpath.2013.07.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3814682PMC
November 2013
6 Reads
16 Citations
4.591 Impact Factor

Therapeutic evaluation of ex vivo-generated versus natural regulatory T-cells in a mouse model of chronic gut inflammation.

Inflamm Bowel Dis 2013 Oct;19(11):2282-94

*Department of Molecular and Cellular Physiology, †Department of Microbiology and Immunology, and ‡Department of Pathology, Louisiana State University Health Sciences Center, Shreveport, Louisiana; and §Department of Immunology and Molecular Microbiology, Texas Tech University Health Sciences Center, Lubbock, Texas.

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http://dx.doi.org/10.1097/MIB.0b013e31829c32ddDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3812251PMC
October 2013
22 Reads
8 Citations
4.464 Impact Factor

Immunopathological patterns from EAE and Theiler's virus infection: Is multiple sclerosis a homogenous 1-stage or heterogenous 2-stage disease?

Pathophysiology 2013 Feb 26;20(1):71-84. Epub 2012 May 26.

Department of Microbiology and Immunology, Center for Molecular and Tumor Virology, LSU Health, School of Medicine, Shreveport, LA 71130, USA.

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http://dx.doi.org/10.1016/j.pathophys.2012.03.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3430756PMC
February 2013
17 Reads
9 Citations

Possible role of interleukin-17 in a prime/challenge model of multiple sclerosis.

J Neurovirol 2012 Dec 19;18(6):471-8. Epub 2012 Sep 19.

Department of Pathology, University of Utah School of Medicine, Salt Lake City, UT 84132, USA.

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http://dx.doi.org/10.1007/s13365-012-0125-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3508306PMC
December 2012
5 Reads
2.600 Impact Factor

Regulatory T cells and Th17 cells in viral infections: implications for multiple sclerosis and myocarditis.

Future Virol 2012 Jun;7(6):593-608

Department of Microbiology & Immunology, Center for Molecular & Tumor Virology, Louisiana State University Health Sciences Center, Shreveport, LA 71130, USA.

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http://dx.doi.org/10.2217/fvl.12.44DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3457923PMC
June 2012
9 Reads
14 Citations
1.000 Impact Factor

Immunization with structural and non-structural proteins of Theiler's murine encephalomyelitis virus alters demyelinating disease.

J Neurovirol 2012 Apr 9;18(2):127-37. Epub 2012 Mar 9.

Department of Microbiology and Immunology, Louisiana State University Health Sciences Center, 1501 Kings Highway, Shreveport, LA 71130, USA.

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http://dx.doi.org/10.1007/s13365-012-0087-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3335973PMC
April 2012
7 Reads
2.600 Impact Factor

Antiviral CD8⁺ T cells cause an experimental autoimmune encephalomyelitis-like disease in naive mice.

J Neurovirol 2012 Feb 27;18(1):45-54. Epub 2012 Jan 27.

Department of Pathology, University of Utah School of Medicine, 30 North 1900 East, 3R330 SOM, Salt Lake City, UT 84132, USA.

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http://dx.doi.org/10.1007/s13365-012-0077-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3327473PMC
February 2012
8 Reads
4 Citations
2.600 Impact Factor

Heterogeneity versus homogeneity of multiple sclerosis.

Expert Rev Clin Immunol 2011 Mar;7(2):165-7

Department of Microbiology and Immunology, Louisiana State University Health Sciences Center, 1501 Kings Highway, Shreveport, LA 71130, USA.

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http://dx.doi.org/10.1586/eci.11.3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3085181PMC
March 2011
11 Reads
3 Citations
3.342 Impact Factor

Theiler's virus infection: Pathophysiology of demyelination and neurodegeneration.

Pathophysiology 2011 Feb;18(1):31-41

Department of Microbiology and Immunology, Louisiana State University Health Sciences Center, School of Medicine in Shreveport, Shreveport, LA 71130, USA.

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http://dx.doi.org/10.1016/j.pathophys.2010.04.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2937201PMC
February 2011
6 Reads
15 Citations

Purkinje cell death after uptake of anti-Yo antibodies in cerebellar slice cultures.

J Neuropathol Exp Neurol 2010 Oct;69(10):997-1007

Neurology Service, George E. Wahlen Veterans Affairs Medical Center, Salt Lake City, UT 84148, USA.

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http://dx.doi.org/10.1097/NEN.0b013e3181f0c82bDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2959164PMC
October 2010
10 Reads
27 Citations
3.800 Impact Factor

Neuropathogenesis of Theiler's murine encephalomyelitis virus infection, an animal model for multiple sclerosis.

J Neuroimmune Pharmacol 2010 Sep 6;5(3):355-69. Epub 2009 Nov 6.

Department of Pathology, University of Utah School of Medicine, 30 North 1900 East, 3R330 SOM, Salt Lake City, UT 84132, USA.

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http://dx.doi.org/10.1007/s11481-009-9179-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2888670PMC
September 2010
5 Reads
31 Citations
4.110 Impact Factor

Studies in the modulation of experimental autoimmune encephalomyelitis.

J Neuroimmune Pharmacol 2010 Jun 17;5(2):168-75. Epub 2010 Apr 17.

Department of Pathology, University of Utah School of Medicine, 30 North 1900 East, 3R330 SOM, Salt Lake City, UT 84132, USA.

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http://dx.doi.org/10.1007/s11481-010-9215-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3046865PMC
June 2010
6 Reads
7 Citations
4.110 Impact Factor

The importance of NAD in multiple sclerosis.

Curr Pharm Des 2009 ;15(1):64-99

Department of Molecular Genetics, Biochemistry, and Microbiology, University of Cincinnati, Cincinnati, Ohio 45237, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2651433PMC
March 2009
8 Reads
19 Citations
3.452 Impact Factor

Contrasting roles for Valpha14+ natural killer T cells in a viral model for multiple sclerosis.

J Neurovirol 2009 Jan 27;15(1):90-8. Epub 2008 Dec 27.

Department of Pathology, Division of Cell Biology and Immunology, University of Utah School of Medicine, 30 North 1900 East, Salt Lake City, UT 84132, USA.

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http://dx.doi.org/10.1080/13550280802400684DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2671644PMC
January 2009
5 Reads
3 Citations
2.600 Impact Factor

Theiler's murine encephalomyelitis virus attachment to the gastrointestinal tract is associated with sialic acid binding.

J Neurovirol 2009 Jan 26;15(1):81-9. Epub 2008 Dec 26.

Department of Pathology, University of Utah School of Medicine, 30 North 1900 East, Salt Lake City, UT 84132, USA.

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http://dx.doi.org/10.1080/13550280802380563DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2882804PMC
January 2009
5 Reads
3 Citations
2.600 Impact Factor

Cross-reactive myelin antibody induces renal pathology.

Autoimmunity 2008 Nov;41(7):526-36

Department of Pathology, University of Utah School of Medicine, Salt Lake City, UT 84132, USA.

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http://dx.doi.org/10.1080/08916930802128680DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3039869PMC
November 2008
9 Reads
3 Citations
2.714 Impact Factor

Targeting myelin proteolipid protein to the MHC class I pathway by ubiquitination modulates the course of experimental autoimmune encephalomyelitis.

J Neuroimmunol 2008 Nov;204(1-2):92-100

Department of Pathology, University of Utah School of Medicine, 30 North 1900 East, RM 3R330, Salt Lake City, Utah 84132, United States.

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http://dx.doi.org/10.1016/j.jneuroim.2008.07.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2646907PMC
November 2008
9 Reads
4 Citations
2.470 Impact Factor

Regulatory role of CD1d in neurotropic virus infection.

J Virol 2008 Oct 6;82(20):10279-89. Epub 2008 Aug 6.

Department of Pathology, Division of Cell Biology & Immunology, University of Utah School of Medicine, 30 North 1900 East, MREB, Room 218, Salt Lake City, UT 84132, USA.

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http://dx.doi.org/10.1128/JVI.00734-08DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2566251PMC
October 2008
17 Reads
13 Citations
4.440 Impact Factor

Role of CD5+ B-1 cells in EAE pathogenesis.

Autoimmunity 2008 Aug;41(5):353-62

Department of Pathology, University of Utah School of Medicine, Salt Lake City, UT 84132, USA.

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http://dx.doi.org/10.1080/08916930801890280DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4399970PMC
August 2008
6 Reads
8 Citations
2.714 Impact Factor

Role of B:T cell ratio in suppression of clinical signs: a model for silent MS.

Exp Mol Pathol 2008 Aug 8;85(1):28-39. Epub 2008 Apr 8.

Department of Pathology, University of Utah School of Medicine, 30 North 1900 East, 3R330 SOM, Salt Lake City, Utah 84132, USA.

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http://dx.doi.org/10.1016/j.yexmp.2008.03.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2614211PMC
August 2008
7 Reads
2.710 Impact Factor

Axonal degeneration as a self-destructive defense mechanism against neurotropic virus infection.

Authors:
Ikuo Tsunoda

Future Virol 2008 ;3(6):579-593

Department of Pathology, Division of Cell Biology & Immunology, University of Utah School of Medicine, 30 North 1900 East, MREB, Room 218, Salt Lake City, Utah 84132, USA.

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http://dx.doi.org/10.2217/17460794.3.6.579DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2600527PMC
January 2008
6 Reads
11 Citations
1.000 Impact Factor

Targeting inflammatory demyelinating lesions to sites of Wallerian degeneration.

Am J Pathol 2007 Nov 6;171(5):1563-75. Epub 2007 Sep 6.

Department of Neurology, University of Utah School of Medicine, Salt Lake City, UT 84132-2305, USA.

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http://dx.doi.org/10.2353/ajpath.2007.070147DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2043517PMC
November 2007
7 Reads
22 Citations
4.591 Impact Factor

TGF-beta1 suppresses T cell infiltration and VP2 puff B mutation enhances apoptosis in acute polioencephalitis induced by Theiler's virus.

J Neuroimmunol 2007 Oct 4;190(1-2):80-9. Epub 2007 Sep 4.

Department of Pathology, University of Utah School of Medicine, 30 North 1900 East, Salt Lake City, UT 84132, USA.

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http://dx.doi.org/10.1016/j.jneuroim.2007.07.026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2128758PMC
October 2007
5 Reads
14 Citations
2.470 Impact Factor

Sequential polymicrobial infections lead to CNS inflammatory disease: possible involvement of bystander activation in heterologous immunity.

J Neuroimmunol 2007 Aug 2;188(1-2):22-33. Epub 2007 Jul 2.

Department of Neurology, University of Utah School of Medicine, 3R330 SOM, Salt Lake City, Utah 84132-2305, United States.

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http://dx.doi.org/10.1016/j.jneuroim.2007.05.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1987327PMC
August 2007
8 Reads
9 Citations
2.470 Impact Factor

Infectious RNA isolated from the spinal cords of mice chronically infected with Theiler's murine encephalomyelitis virus.

J Virol 2007 Mar 27;81(6):3009-11. Epub 2006 Sep 27.

Department of Neurology, University of Utah School of Medicine, 30 North 1900 East, 3R330 SOM, Salt Lake City, UT 84132-2305, USA.

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http://dx.doi.org/10.1128/JVI.01663-06DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1865972PMC
March 2007
7 Reads
1 Citation
4.440 Impact Factor

Polyreactive myelin oligodendrocyte glycoprotein antibodies: Implications for systemic autoimmunity in progressive experimental autoimmune encephalomyelitis.

J Neuroimmunol 2007 Feb 2;183(1-2):69-80. Epub 2007 Jan 2.

Department of Neurology, University of Utah School of Medicine, 30 North 1900 East, 3R330 SOM, Salt Lake City, UT 84132-2305, USA.

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http://dx.doi.org/10.1016/j.jneuroim.2006.11.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1829444PMC
February 2007
10 Reads
3 Citations
2.470 Impact Factor

Contrasting roles for axonal degeneration in an autoimmune versus viral model of multiple sclerosis: When can axonal injury be beneficial?

Am J Pathol 2007 Jan;170(1):214-26

Department of Neurology, University of Utah School of Medicine, 30 North 1900 East, Room 3R330, Salt Lake City, UT 84132, USA.

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http://dx.doi.org/10.2353/ajpath.2007.060683DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1762678PMC
January 2007
5 Reads
18 Citations
4.591 Impact Factor

Modulation of experimental autoimmune encephalomyelitis by VLA-2 blockade.

Brain Pathol 2007 Jan;17(1):45-55

Department of Neurology, University of Utah School of Medicine, Salt Lake City, Utah 84132-2305, USA.

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http://dx.doi.org/10.1111/j.1750-3639.2006.00042.xDOI Listing
January 2007
7 Reads
15 Citations
3.840 Impact Factor

The pathologic role for COX-2 in apoptotic oligodendrocytes in virus induced demyelinating disease: implications for multiple sclerosis.

J Neuroimmunol 2006 May 3;174(1-2):21-31. Epub 2006 Mar 3.

Geriatric Research Education and Clinical Center (GRECC), Salt Lake City, UT 84148, USA.

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http://dx.doi.org/10.1016/j.jneuroim.2006.01.008DOI Listing
May 2006
9 Reads
18 Citations
2.470 Impact Factor

Monoclonal MOG-reactive autoantibody from progressive EAE has the characteristics of a natural antibody.

J Neuroimmunol 2006 Apr 8;173(1-2):135-45. Epub 2006 Feb 8.

Department of Neurology, University of Utah School of Medicine, 30 North 1900 East, 3R330 SOM, Salt Lake City, UT 84132-2305, USA.

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http://dx.doi.org/10.1016/j.jneuroim.2005.12.010DOI Listing
April 2006
6 Reads
5 Citations
2.470 Impact Factor

IFN-gamma production and astrocyte recognition by autoreactive T cells induced by Theiler's virus infection: role of viral strains and capsid proteins.

J Neuroimmunol 2006 Mar 20;172(1-2):85-93. Epub 2005 Dec 20.

Department of Neurology, University of Utah School of Medicine, 30 North 1900 East, Room 3R330, Salt Lake City, Utah 84132-2305, United States.

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http://dx.doi.org/10.1016/j.jneuroim.2005.11.004DOI Listing
March 2006
8 Reads
9 Citations
2.470 Impact Factor

Multiple sclerosis and virus induced immune responses: autoimmunity can be primed by molecular mimicry and augmented by bystander activation.

Autoimmunity 2006 Feb;39(1):9-19

University of Utah School of Medicine, Department of Neurology, 30 North 1900 East, Room 3R330, Salt Lake City, UT 84132-2305, USA.

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http://dx.doi.org/10.1080/08916930500484799DOI Listing
February 2006
6 Reads
24 Citations
2.714 Impact Factor

Massive apoptosis in lymphoid organs in animal models for primary and secondary progressive multiple sclerosis.

Am J Pathol 2005 Dec;167(6):1631-46

Department of Neurology, University of Utah School of Medicine, Salt Lake City, 84132-2305, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1613181PMC
http://dx.doi.org/10.1016/S0002-9440(10)61247-3DOI Listing
December 2005
8 Reads
17 Citations
4.591 Impact Factor

Central nervous system pathology caused by autoreactive CD8+ T-cell clones following virus infection.

J Virol 2005 Dec;79(23):14640-6

Department of Neurology, University of Utah School of Medicine, Salt Lake City, Utah 84132, USA.

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http://dx.doi.org/10.1128/JVI.79.23.14640-14646.2005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1287580PMC
December 2005
6 Reads
14 Citations
4.440 Impact Factor

Converting relapsing remitting to secondary progressive experimental allergic encephalomyelitis (EAE) by ultraviolet B irradiation.

J Neuroimmunol 2005 Mar 29;160(1-2):122-34. Epub 2004 Dec 29.

Department of Neurology, University of Utah School of Medicine, 30 North 1900 East, Salt Lake City, UT 84132-2305, USA.

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http://dx.doi.org/10.1016/j.jneuroim.2004.11.007DOI Listing
March 2005
12 Reads
10 Citations
2.470 Impact Factor

Distinct roles for IP-10/CXCL10 in three animal models, Theiler's virus infection, EAE, and MHV infection, for multiple sclerosis: implication of differing roles for IP-10.

Mult Scler 2004 Feb;10(1):26-34

Department of Neurology, University of Utah School of Medicine, 30 North 1900 East, Salt Lake City, UT 84132-2305, USA.

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http://dx.doi.org/10.1191/1352458504ms982oaDOI Listing
February 2004
8 Reads
31 Citations
4.822 Impact Factor

Modulation of immune system function by measles virus infection. II. Infection of B cells leads to the production of a soluble factor that arrests uninfected B cells in G0/G1.

Viral Immunol 2003 ;16(1):45-55

Division of Hematology/Oncology/Bone-Marrow Transplantation, The Children's Hospital Denver, Colorado, USA.

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http://dx.doi.org/10.1089/088282403763635447DOI Listing
June 2003
8 Reads
4 Citations
1.640 Impact Factor

Inside-Out versus Outside-In models for virus induced demyelination: axonal damage triggering demyelination.

Springer Semin Immunopathol 2002 ;24(2):105-25

Department of Neurology, 3R330 School of Medicine, University of Utah, 30 North 1900 East, Salt Lake City, Utah 84132-2305, USA.

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http://dx.doi.org/10.1007/s00281-002-0105-zDOI Listing
June 2003
6 Reads
42 Citations

Axonal injury heralds virus-induced demyelination.

Am J Pathol 2003 Apr;162(4):1259-69

Department of Neurology, University of Utah School of Medicine, Salt Lake City, Utah 84132, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1851221PMC
http://dx.doi.org/10.1016/S0002-9440(10)63922-3DOI Listing
April 2003
7 Reads
44 Citations
4.591 Impact Factor

Induction of autoreactive CD8+ cytotoxic T cells during Theiler's murine encephalomyelitis virus infection: implications for autoimmunity.

J Virol 2002 Dec;76(24):12834-44

Department of Neurology, University of Utah School of Medicine, 30 North 1900 East, Salt Lake City, UT 84132, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC136689PMC
December 2002
6 Reads
17 Citations
4.440 Impact Factor

Mutation in loop I of VP1 of Theiler's virus delays viral RNA release into cells and enhances antibody-mediated neutralization: a mechanism for the failure of persistence by the mutant virus.

J Neurovirol 2002 Apr;8(2):100-10

Department of Neurology, University of Utah School of Medicine, Salt Lake City, USA.

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http://dx.doi.org/10.1080/13550280290049561DOI Listing
April 2002
10 Reads
4 Citations
2.600 Impact Factor

Altered cell growth and morphology in a BHK-21 cell mutant that lacks a receptor for Theiler's murine encephalomyelitis virus.

Virology 2002 Mar;294(1):85-93

Department of Neurology, University of Utah School of Medicine, 30 N 1900 E, Room 3R330, Salt Lake City, UT 84132, USA.

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http://dx.doi.org/10.1006/viro.2001.1312DOI Listing
March 2002
8 Reads
3.321 Impact Factor

Top co-authors

Robert S Fujinami
Robert S Fujinami

University of Utah School of Medicine

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Fumitaka Sato
Fumitaka Sato

Louisiana State University Health Sciences Center

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Seiichi Omura
Seiichi Omura

Kindai University Faculty of Medicine

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Jane E Libbey
Jane E Libbey

University of Utah School of Medicine

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Nicholas E Martinez
Nicholas E Martinez

Center for Molecular and Tumor Virology

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Eiichiro Kawai
Eiichiro Kawai

Center for Molecular and Tumor Virology

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Alireza Minagar
Alireza Minagar

Louisiana State University Health Sciences Center

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Noel G Carlson
Noel G Carlson

Geriatric Research Education and Clinical Center (GRECC)

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Lisa K Peterson
Lisa K Peterson

University of Utah School of Medicine

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