Ikuo Sekine

Ikuo Sekine

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Ikuo Sekine

Publications by authors named "Ikuo Sekine"

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Metabolic Diversity in Human Non-Small Cell Lung Cancer Cells.

Mol Cell 2019 12 26;76(5):838-851.e5. Epub 2019 Sep 26.

Children's Medical Center Research Institute at UT Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX 75390, USA; Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX 75390, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2019.08.028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6898782PMC
December 2019

A Prompt Diagnosis of Superior Vena Cava Obstruction Established by Physical Examination.

Authors:
Ikuo Sekine

Intern Med 2019 11 10;58(22):3211-3212. Epub 2019 Jul 10.

Department of Medical Oncology, Faculty of Medicine, University of Tsukuba, Japan.

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http://dx.doi.org/10.2169/internalmedicine.3151-19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6911752PMC
November 2019

Small-Cell Lung Cancer Treatment of Newly Diagnosed Patients with Poor Performance Status.

Case Rep Oncol 2019 May-Aug;12(2):613-620. Epub 2019 Aug 6.

Department of Respiratory Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan.

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http://dx.doi.org/10.1159/000501548DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6738152PMC
August 2019

Serum Soluble Interleukin-2 Receptor as a Possible Biomarker for the Early Detection and Follow-up of Nivolumab-Induced Pneumonitis.

J Thorac Oncol 2019 05;14(5):e90-e91

Department of Pulmonary Medicine, Division of Clinical Medicine, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan.

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http://dx.doi.org/10.1016/j.jtho.2018.12.028DOI Listing
May 2019

Induction systemic therapy followed by surgery for stages II-III non-small cell lung cancer: steady efforts.

J Thorac Dis 2018 Nov;10(Suppl 33):S3942-S3945

Department of Medical Oncology, Faculty of Medicine, University of Tsukuba, Tennodai 1-1-1, Tsukuba, Ibaraki 305-8575, Japan.

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http://jtd.amegroups.com/article/view/24415/18978
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http://dx.doi.org/10.21037/jtd.2018.09.91DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6297469PMC
November 2018

Rechallenge with First-Line Platinum Chemotherapy for Sensitive-Relapsed Small-Cell Lung Cancer.

Case Rep Oncol 2018 Sep-Dec;11(3):622-632. Epub 2018 Sep 7.

Department of Respiratory Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan.

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https://www.karger.com/Article/FullText/492780
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http://dx.doi.org/10.1159/000492780DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6180263PMC
September 2018

Immune checkpoint inhibitor-related myocarditis.

Jpn J Clin Oncol 2018 Jan;48(1):7-12

Department of Medical Oncology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan.

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http://academic.oup.com/jjco/article/48/1/7/4555358
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http://dx.doi.org/10.1093/jjco/hyx154DOI Listing
January 2018

Augmented expression of cardiac ankyrin repeat protein is induced by pemetrexed and a possible marker for the pemetrexed resistance in mesothelioma cells.

Cancer Cell Int 2017 11;17:120. Epub 2017 Dec 11.

Division of Pathology and Cell Therapy, Chiba Cancer Center Research Institute, 666-2 Nitona, Chuo-ku, Chiba, 260-8717 Japan.

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http://dx.doi.org/10.1186/s12935-017-0493-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5725641PMC
December 2017

Cardiovascular toxic effects of targeted cancer therapy.

Jpn J Clin Oncol 2017 Sep;47(9):779-785

Department of Medical Oncology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan.

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http://dx.doi.org/10.1093/jjco/hyx071DOI Listing
September 2017

Cardio-oncology: a multidisciplinary approach for detection, prevention and management of cardiac dysfunction in cancer patients.

Jpn J Clin Oncol 2017 Aug;47(8):678-682

Department of Medical Oncology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan.

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http://dx.doi.org/10.1093/jjco/hyx068DOI Listing
August 2017

Osimertinib-Induced Interstitial Lung Disease Presenting as Eosinophilic Pneumonia.

J Thorac Oncol 2017 08;12(8):e118-e120

Department of Medical Oncology, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan.

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http://dx.doi.org/10.1016/j.jtho.2017.03.022DOI Listing
August 2017

Retrospective analysis of lung cancer patients treated with supportive care alone.

Int J Clin Oncol 2017 Jun 31;22(3):455-460. Epub 2017 Jan 31.

Division of Respiratory Medicine, Chiba Cancer Center, 666-2 Nitonacho, Chuo-ku, Chiba City, Chiba, 260-8717, Japan.

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http://dx.doi.org/10.1007/s10147-017-1094-1DOI Listing
June 2017

Azathioprine combination therapy for steroid-refractory hepatic immune system-related adverse events.

Eur J Dermatol 2017 06;27(3):301-303

Department of Dermatology, University of Tsukuba, Tsukuba, Ibaraki, Japan.

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http://dx.doi.org/10.1684/ejd.2017.2973DOI Listing
June 2017

What is the optimal first-line treatment for advanced anaplastic lymphoma kinase-rearranged non-small cell lung cancer?

Authors:
Ikuo Sekine

J Thorac Dis 2017 May;9(5):E447-E450

Department of Medical Oncology, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan.

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http://dx.doi.org/10.21037/jtd.2017.04.43DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5465132PMC
May 2017

Case reports of adverse drug reactions associated with nivolumab administration.

Authors:
Ikuo Sekine

Jpn J Clin Oncol 2017 03;47(3):193

Department of Medical Oncology, Faculty of Medicine, University of Tsukuba, Tennodai 1-1-1, Tsukuba-City, Ibaraki 305-8575, Japan.

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http://dx.doi.org/10.1093/jjco/hyx014DOI Listing
March 2017

Afatinib-Induced Severe Interstitial Lung Disease Successfully Treated with High-Dose Corticosteroid Therapy: A Case Report.

J Thorac Oncol 2017 02 22;12(2):e11-e13. Epub 2016 Oct 22.

Department of Respiratory Medicine, Division of Clinical Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan.

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http://dx.doi.org/10.1016/j.jtho.2016.10.011DOI Listing
February 2017

Severe hepatitis arising from ipilimumab administration, following melanoma treatment with nivolumab.

Jpn J Clin Oncol 2017 02;47(2):175-178

Department of Dermatology, University of Tsukuba, Ibaraki, Japan.

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http://dx.doi.org/10.1093/jjco/hyw167DOI Listing
February 2017

Are there any differences in genomic characterization of non-small cell lung cancer between African Americans and Whites?

Authors:
Ikuo Sekine

J Thorac Dis 2016 Nov;8(11):E1517-E1519

Department of Medical Oncology, Faculty of Medicine, University of Tsukuba, Tennodai 1-1-1, Tsukuba, Ibaraki 305-8575, Japan.

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http://dx.doi.org/10.21037/jtd.2016.11.65DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5179411PMC
November 2016

An intrapleural administration of zoledronic acid for inoperable malignant mesothelioma patients: a phase I clinical study protocol.

Springerplus 2016 27;5:195. Epub 2016 Feb 27.

Division of Pathology and Cell Therapy, Chiba Cancer Center Research Institute, 666-2 Nitona, Chuo-ku, Chiba, 260-8717 Japan ; Department of Molecular Biology and Oncology, Graduate School of Medicine, Chiba University, Chiba, Japan.

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http://dx.doi.org/10.1186/s40064-016-1893-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4769234PMC
March 2016

Phase II study of amrubicin at a dose of 45 mg/m2 in patients with previously treated small-cell lung cancer.

Jpn J Clin Oncol 2015 Oct 31;45(10):941-6. Epub 2015 Jul 31.

Department of Thoracic Oncology, National Cancer Center Hospital, Tokyo.

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http://dx.doi.org/10.1093/jjco/hyv107DOI Listing
October 2015

Alveolar hemorrhage associated with pemetrexed administration.

Intern Med 2015 1;54(7):833-6. Epub 2015 Apr 1.

Department of Medical Oncology, Graduate School of Medicine, Chiba University, Japan.

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http://dx.doi.org/10.2169/internalmedicine.54.3414DOI Listing
September 2015

[Targeted therapy for solid tumors in the elderly].

Nihon Rinsho 2015 Aug;73(8):1419-24

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August 2015

A clinical protocol to inhibit the HGF/c-Met pathway for malignant mesothelioma with an intrapleural injection of adenoviruses expressing the NK4 gene.

Springerplus 2015 16;4:358. Epub 2015 Jul 16.

Division of Pathology and Cell Therapy, Chiba Cancer Center Research Institute, 666-2 Nitona, Chuo-ku, Chiba, 260-8717 Japan ; Department of Molecular Biology and Oncology, Graduate School of Medicine, Chiba University, Chiba, Japan.

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http://www.springerplus.com/content/4/1/358
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http://dx.doi.org/10.1186/s40064-015-1123-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4503710PMC
July 2015

Chronic obstructive pulmonary disease as a risk factor for lung cancer.

World J Clin Oncol 2014 Oct;5(4):660-6

Yuichi Takiguchi, Ikuo Sekine, Shunichiro Iwasawa, Ryota Kurimoto, Department of Medical Oncology, Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan.

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http://dx.doi.org/10.5306/wjco.v5.i4.660DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4129530PMC
October 2014

Current status of medical oncology in Japan--reality gleaned from a questionnaire sent to designated cancer care hospitals.

Jpn J Clin Oncol 2014 Jul 12;44(7):632-40. Epub 2014 May 12.

Department of Medical Oncology, Chuo Hospital, National Cancer Center, Tokyo, Japan.

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http://dx.doi.org/10.1093/jjco/hyu059DOI Listing
July 2014

Stereotactic radiosurgery for patients with brain metastases.

Lancet Oncol 2014 Jun;15(7):e247-8

Department of Reproductive Medicine, Graduate School of Medicine, Chiba University, Chiba, Japan.

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https://linkinghub.elsevier.com/retrieve/pii/S14702045147018
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http://dx.doi.org/10.1016/S1470-2045(14)70182-2DOI Listing
June 2014

Clinical characteristics and functional assessment of elderly patients with cancer.

Authors:
Ikuo Sekine

Rinsho Ketsueki 2014 05;55(5):518-25

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May 2014

Incidence, risk factors and treatment outcomes of extravasation of cytotoxic agents in an outpatient chemotherapy clinic.

Jpn J Clin Oncol 2014 Feb 2;44(2):168-71. Epub 2013 Dec 2.

*Department of Medical Oncology, Graduate School of Medicine, Chiba University, Inohana 1-8-1, Chuo-ku, Chiba 260-8670, Japan.

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http://dx.doi.org/10.1093/jjco/hyt186DOI Listing
February 2014

Short hydration in chemotherapy containing cisplatin (≥75 mg/m2) for patients with lung cancer: a prospective study.

Jpn J Clin Oncol 2013 Nov 4;43(11):1105-9. Epub 2013 Sep 4.

*Division of Thoracic Oncology, National Cancer Center Hospital, Tsukiji 5-1-1, Chuo-ku, Tokyo 104-0045, Japan.

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http://dx.doi.org/10.1093/jjco/hyt122DOI Listing
November 2013

Overdiagnosis in lung cancer screening with low-dose computed tomography.

J Thorac Oncol 2013 Nov;8(11):e101-2

Department of Medical Oncology Graduate School of Medicine Chiba University Chiba, Japan.

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http://dx.doi.org/10.1097/JTO.0b013e3182a476d4DOI Listing
November 2013

Choroidal metastasis of non-small cell lung cancer that responded to gefitinib.

Case Rep Ophthalmol Med 2013 12;2013:213124. Epub 2013 Sep 12.

Department of Respirology, Graduate School of Medicine, Chiba University, 1-8-1 Inohana Chuo-ku, Chiba 260-8677, Japan.

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http://dx.doi.org/10.1155/2013/213124DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3787632PMC
October 2013

Risk factors of chemotherapy-induced nausea and vomiting: index for personalized antiemetic prophylaxis.

Cancer Sci 2013 Jun 16;104(6):711-7. Epub 2013 Apr 16.

Division of Internal Medicine and Thoracic Oncology, National Cancer Center Hospital, Tokyo, Japan.

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http://dx.doi.org/10.1111/cas.12146DOI Listing
June 2013

Clinical classification of targeted agents used for anticancer treatment.

Tohoku J Exp Med 2013 05;230(1):1-5

Department of Medical Oncology, Graduate School of Medicine, Chiba University, Chiba City, Chiba, Japan.

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http://dx.doi.org/10.1620/tjem.230.1DOI Listing
May 2013

Long-term results of concurrent chemoradiotherapy using cisplatin and vinorelbine for stage III non-small-cell lung cancer.

Cancer Sci 2013 Jan 8;104(1):93-7. Epub 2012 Nov 8.

Division of Internal Medicine and Thoracic Oncology, National Cancer Center Hospital, Tokyo, Japan.

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http://dx.doi.org/10.1111/cas.12028DOI Listing
January 2013

Gender difference in hematological toxicity among lung cancer patients receiving amrubicin monotherapy.

Jpn J Clin Oncol 2012 Dec 17;42(12):1187-91. Epub 2012 Oct 17.

Division of Pharmacy, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, Japan.

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http://dx.doi.org/10.1093/jjco/hys170DOI Listing
December 2012

Pharmacokinetic and pharmacodynamic study on amrubicin and amrubicinol in Japanese patients with lung cancer.

Cancer Chemother Pharmacol 2012 Apr 1;69(4):861-9. Epub 2011 Nov 1.

Department of Pharmacy, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, Japan.

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http://dx.doi.org/10.1007/s00280-011-1768-8DOI Listing
April 2012

Brain metastases after definitive concurrent chemoradiotherapy in patients with stage III lung adenocarcinoma: carcinoembryonic antigen as a potential predictive factor.

Cancer Sci 2012 Apr 20;103(4):756-9. Epub 2012 Feb 20.

Division of Internal Medicine and Thoracic Oncology, National Cancer Center Hospital, Chuo-ku, Tokyo, Japan.

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http://dx.doi.org/10.1111/j.1349-7006.2012.02217.xDOI Listing
April 2012

c-MET/phospho-MET protein expression and MET gene copy number in non-small cell lung carcinomas.

J Thorac Oncol 2012 Feb;7(2):331-9

Division of Pathology and Clinical Laboratories, National Cancer Center Hospital, Tokyo, Japan.

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http://dx.doi.org/10.1097/JTO.0b013e318241655fDOI Listing
February 2012

Retrospective analysis of third-line and fourth-line chemotherapy for advanced non-small-cell lung cancer.

Clin Lung Cancer 2012 Jan 3;13(1):39-43. Epub 2011 Sep 3.

Division of Internal Medicine and Thoracic Oncology, National Cancer Center Hospital, Tokyo, Japan.

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http://linkinghub.elsevier.com/retrieve/pii/S152573041100156
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http://dx.doi.org/10.1016/j.cllc.2011.06.008DOI Listing
January 2012

[The cutting-edge of medicine; Ethnic and gender differences in lung cancer].

Nihon Naika Gakkai Zasshi 2011 Oct;100(10):3064-71

Division of Internal Medicine and Thoracic Oncology, National Cancer Center Hospital, Japan.

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http://dx.doi.org/10.2169/naika.100.3064DOI Listing
October 2011

Combination chemotherapy with carboplatin and paclitaxel for advanced thymic cancer.

Jpn J Clin Oncol 2011 Aug 7;41(8):1013-6. Epub 2011 Jul 7.

Division of Internal Medicine and Thoracic Oncology, National Cancer Center Hospital, Tsukiji 5-1-1, Chuo-ku, Tokyo 104-0045, Japan.

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http://dx.doi.org/10.1093/jjco/hyr089DOI Listing
August 2011

Amrubicin monotherapy for patients with previously treated advanced large-cell neuroendocrine carcinoma of the lung.

Jpn J Clin Oncol 2011 Jul 2;41(7):897-901. Epub 2011 Jun 2.

Division of Internal Medicine and Thoracic Oncology, National Cancer Center Hospital, Tsukiji 5-1-1, Chuo-ku, Tokyo 104-0045, Japan.

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http://dx.doi.org/10.1093/jjco/hyr065DOI Listing
July 2011

Frequent ALK rearrangement and TTF-1/p63 co-expression in lung adenocarcinoma with signet-ring cell component.

Lung Cancer 2011 Jun 30;72(3):309-15. Epub 2010 Oct 30.

Clinical Laboratory Division, National Cancer Center Hospital, Japan.

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http://dx.doi.org/10.1016/j.lungcan.2010.09.013DOI Listing
June 2011

Innovator and generic cisplatin formulations: comparison of renal toxicity.

Cancer Sci 2011 Jan 5;102(1):162-5. Epub 2010 Nov 5.

Division of Internal Medicine and Thoracic Oncology, National Cancer Center Hospital, Tokyo, Japan.

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http://dx.doi.org/10.1111/j.1349-7006.2010.01764.xDOI Listing
January 2011

A dose-finding and pharmacokinetic study of nedaplatin in elderly patients with advanced non-small cell lung cancer.

Cancer Chemother Pharmacol 2009 Dec 26;65(1):79-88. Epub 2009 Apr 26.

Division of Internal Medicine, National Cancer Center Hospital, 5-1-1, Tsukiji Chuo-ku, Tokyo 104-0045, Japan.

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http://dx.doi.org/10.1007/s00280-009-1006-9DOI Listing
December 2009

Gender difference in treatment outcomes in patients with stage III non-small cell lung cancer receiving concurrent chemoradiotherapy.

Jpn J Clin Oncol 2009 Nov 19;39(11):707-12. Epub 2009 Aug 19.

Division of Internal Medicine and Thoracic Oncology, National Cancer Center Hospital, Tsukiji 5-1-1, Chuo-ku, Tokyo 104-0045, Japan.

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https://academic.oup.com/jjco/article-lookup/doi/10.1093/jjc
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http://dx.doi.org/10.1093/jjco/hyp095DOI Listing
November 2009

Risk factors for skeletal-related events in patients with non-small cell lung cancer treated by chemotherapy.

Lung Cancer 2009 Aug 10;65(2):219-22. Epub 2008 Dec 10.

Division of Internal Medicine and Thoracic Oncology, National Cancer Center Hospital, Tsukiji 5-1-1, Chuo-ku, Tokyo 104-0045, Japan.

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http://dx.doi.org/10.1016/j.lungcan.2008.10.026DOI Listing
August 2009

A pharmacokinetic and dose escalation study of pegfilgrastim (KRN125) in lung cancer patients with chemotherapy-induced neutropenia.

Jpn J Clin Oncol 2009 Jul 24;39(7):425-30. Epub 2009 Apr 24.

Division of Thoracic Oncology, Shizuoka Cancer Center, Sunto-gun, Shizuoka, Japan.

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http://dx.doi.org/10.1093/jjco/hyp038DOI Listing
July 2009

Differences in the quality of information on the internet about lung cancer between the United States and Japan.

J Thorac Oncol 2009 Jul;4(7):829-33

Division of Internal Medicine and Thoracic Oncology, National Cancer Center Hospital, Chuo-ku, Tokyo, Japan.

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http://dx.doi.org/10.1097/JTO.0b013e3181a76fe1DOI Listing
July 2009

Comparative chemotherapeutic efficacy in non-small cell lung cancer patients with postoperative recurrence and stage IV disease.

J Thorac Oncol 2009 Apr;4(4):518-21

Division of Internal Medicine and Thoracic Oncology, National Cancer Center Hospital, Tokyo, Japan.

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http://dx.doi.org/10.1097/jto.0b013e31819c7bc9DOI Listing
April 2009

A literature review of molecular markers predictive of clinical response to cytotoxic chemotherapy in patients with breast cancer.

Int J Clin Oncol 2009 Apr 24;14(2):112-9. Epub 2009 Apr 24.

Division of Internal Medicine and Thoracic Oncology, National Cancer Center Hospital, Tsukiji 5-1-1, Chuo-ku, Tokyo, 104-0045, Japan.

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http://dx.doi.org/10.1007/s10147-008-0813-zDOI Listing
April 2009

Is there a need to take ethnicity into account when considering lung cancer treatment?

Authors:
Ikuo Sekine

Expert Rev Respir Med 2009 Feb;3(1):1-4

Division of Internal Medicine and Thoracic Oncology, National Cancer Center Hospital, Tsukiji 5-1-1, Chuo-ku, Tokyo 104-0045, Japan.

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http://dx.doi.org/10.1586/17476348.3.1.1DOI Listing
February 2009

EGFR mutations predict survival benefit from gefitinib in patients with advanced lung adenocarcinoma: a historical comparison of patients treated before and after gefitinib approval in Japan.

J Clin Oncol 2008 Dec 15;26(34):5589-95. Epub 2008 Sep 15.

Division of Internal Medicine, Research Center for Cancer Prevention and Screening, National Cancer Center Hospital, Tokyo 104-0045, Japan.

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http://dx.doi.org/10.1200/JCO.2008.16.7254DOI Listing
December 2008

Gender differences in treatment outcomes among patients with non-small cell lung cancer given a combination of carboplatin and paclitaxel.

Oncology 2008 1;75(3-4):169-74. Epub 2008 Oct 1.

Division of Internal Medicine and Thoracic Oncology, National Cancer Center Hospital, Tokyo, Japan.

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http://dx.doi.org/10.1159/000159268DOI Listing
November 2008

Local control of regional and metastatic lesions and indication for systemic chemotherapy in patients with non-small cell lung cancer.

Oncologist 2008 ;13 Suppl 1:21-7

Division of Internal Medicine and Thoracic Oncology, National Cancer Center Hospital, Tsukiji 5-1-1, Tokyo 104-0045, Japan.

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http://dx.doi.org/10.1634/theoncologist.13-S1-21DOI Listing
April 2008

Influence of previous chemotherapy on the efficacy of subsequent docetaxel therapy in advanced non-small cell lung cancer patients.

J Thorac Oncol 2008 Apr;3(4):412-6

Division of Internal Medicine and Thoracic Oncology, National Cancer Center Hospital, Chuo-ku, Tokyo, Japan.

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http://dx.doi.org/10.1097/JTO.0b013e318168d1f1DOI Listing
April 2008