Ikuo Igarashi

Ikuo Igarashi

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Ikuo Igarashi

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Safety and efficacy of hydroxyurea and eflornithine against most blood parasites Babesia and Theileria.

PLoS One 2020 13;15(2):e0228996. Epub 2020 Feb 13.

National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido, Japan.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0228996PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7018007PMC
May 2020

Closing the empty anti-Babesia gibsoni drug pipeline in vitro using fluorescence-based high throughput screening assay.

Parasitol Int 2020 Apr 10;75:102054. Epub 2020 Jan 10.

National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Inada-Cho, Obihiro, Hokkaido 080-8555, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.parint.2020.102054DOI Listing
April 2020

Clofazimine, a promising drug for the treatment of Babesia microti infection in severely immunocompromised hosts.

J Infect Dis 2020 Apr 20. Epub 2020 Apr 20.

National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Inada-cho, Obihiro, Hokkaido, Japan.

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http://dx.doi.org/10.1093/infdis/jiaa195DOI Listing
April 2020

Drug screening of food and drug administration-approved compounds against Babesia bovis in vitro.

Exp Parasitol 2020 Mar 8;210:107831. Epub 2020 Jan 8.

National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, 080-8555, Hokkaido, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.exppara.2020.107831DOI Listing
March 2020

Assay methods for in vitro and in vivo anti-Babesia drug efficacy testing: Current progress, outlook, and challenges.

Vet Parasitol 2020 Mar 13;279:109013. Epub 2019 Dec 13.

National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Inada-Cho, Obihiro, Hokkaido, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.vetpar.2019.109013DOI Listing
March 2020

Gas chromatography-mass spectrometry analysis, phytochemical screening and antiprotozoal effects of the methanolic Viola tricolor and acetonic Laurus nobilis extracts.

BMC Complement Med Ther 2020 Mar 17;20(1):87. Epub 2020 Mar 17.

National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Nishi 2-13, Inada-cho, Obihiro, Hokkaido, 080-8555, Japan.

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http://dx.doi.org/10.1186/s12906-020-2848-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7077018PMC
March 2020

Therapeutic Effects of Atranorin towards the Proliferation of and Parasites.

Pathogens 2020 Feb 17;9(2). Epub 2020 Feb 17.

National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Nishi 2-13, Inada-cho 080-8555, Obihiro, Hokkaido, Japan.

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http://dx.doi.org/10.3390/pathogens9020127DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7167990PMC
February 2020

Phytochemical Characterization and Chemotherapeutic Potential of Extracts on the Multiplication of Protozoan Parasites In Vitro and In Vivo.

Molecules 2020 Feb 24;25(4). Epub 2020 Feb 24.

National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Nishi 2-13, Inada-cho, Obihiro, Hokkaido 080-8555, Japan.

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http://dx.doi.org/10.3390/molecules25040996DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7070835PMC
February 2020

Myrrh Oil Inhibitory Growth on Bovine and Equine Piroplasm Parasites and of Mice.

Pathogens 2020 Feb 29;9(3). Epub 2020 Feb 29.

National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Inada-Cho, Obihiro, Hokkaido 080-8555, Japan.

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http://dx.doi.org/10.3390/pathogens9030173DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7157210PMC
February 2020

Phytochemical Screening and Antiprotozoal Effects of the Methanolic and Acetonic coriaria Extracts.

Molecules 2020 Jan 27;25(3). Epub 2020 Jan 27.

National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Nishi 2-13, Inada-cho, 080-8555, Obihiro, Hokkaido, Japan.

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http://dx.doi.org/10.3390/molecules25030550DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7037273PMC
January 2020

Highly sensitive nested PCR and rapid immunochromatographic detection of Babesia bovis and Babesia bigemina infection in a cattle herd with acute clinical and fatal cases in Argentina.

Transbound Emerg Dis 2019 Dec 27. Epub 2019 Dec 27.

National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Japan.

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http://dx.doi.org/10.1111/tbed.13435DOI Listing
December 2019

Cocktail Babesia bovis antigens for global detection of Babesia bovis infection in cattle.

Exp Parasitol 2019 Nov 12;206:107758. Epub 2019 Sep 12.

National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Inada-Cho, Obihiro, Hokkaido, 080-8555, Japan.

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http://dx.doi.org/10.1016/j.exppara.2019.107758DOI Listing
November 2019

Epidemiological survey of Anaplasma marginale in cattle and buffalo in Sri Lanka.

J Vet Med Sci 2019 Nov 20;81(11):1601-1605. Epub 2019 Sep 20.

National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Hokkaido 080-8555, Japan.

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http://dx.doi.org/10.1292/jvms.19-0242DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6895639PMC
November 2019

Discovering the in vitro potent inhibitors against Babesia and Theileria parasites by repurposing the Malaria Box: A review.

Vet Parasitol 2019 Oct 19;274:108895. Epub 2019 Jul 19.

National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Inada-cho, Obihiro, Hokkaido 080-8555, Japan. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S03044017193016
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http://dx.doi.org/10.1016/j.vetpar.2019.07.003DOI Listing
October 2019

Inhibitory effects of Syzygium aromaticum and Camellia sinensis methanolic extracts on the growth of Babesia and Theileria parasites.

Ticks Tick Borne Dis 2019 08 28;10(5):949-958. Epub 2019 Apr 28.

National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Nishi 2 Sen-11, Inada-cho, Obihiro, Hokkaido, 080-8555, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.ttbdis.2019.04.016DOI Listing
August 2019

Screening the Medicines for Malaria Venture Pathogen Box against piroplasm parasites.

Int J Parasitol Drugs Drug Resist 2019 08 19;10:84-90. Epub 2019 Jun 19.

National Research Center for Protozoan Diseases, Obihiro University of Agriculture Veterinary Medicine, Nishi 2 Sen-13, Inada-cho, Obihiro, Hokkaido, 080-8555, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.ijpddr.2019.06.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6603297PMC
August 2019

A Seroepidemiological Survey of and in Horses in Mongolia.

J Parasitol 2019 08;105(4):580-586

2   National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Inada-cho, Obihiro, Hokkaido 080-8555, Japan.

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August 2019

Evaluation of the inhibitory effect of ivermectin on the growth of and parasites in vitro and in vivo.

Trop Med Health 2019 11;47:42. Epub 2019 Jul 11.

1National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Nishi 2-13, Inada-cho, Obihiro, Hokkaido 080-8555 Japan.

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http://dx.doi.org/10.1186/s41182-019-0171-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6625054PMC
July 2019

Flavonoids isolated from the flowers of Pulsatilla flavescens and their anti-piroplasm activity.

J Nat Med 2019 Jun 7;73(3):633-640. Epub 2019 Mar 7.

School of Engineering and Applied Sciences, National University of Mongolia, P.O.B.-617/46A, Ulaanbaatar, 14201, Mongolia.

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http://dx.doi.org/10.1007/s11418-019-01294-8DOI Listing
June 2019

A Review on Equine Piroplasmosis: Epidemiology, Vector Ecology, Risk Factors, Host Immunity, Diagnosis and Control.

Int J Environ Res Public Health 2019 05 16;16(10). Epub 2019 May 16.

Unit for Environmental Sciences and Management, North West University, Potchefstroom Campus, Private Bag X6001, Potchefstroom 2520, South Africa.

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http://dx.doi.org/10.3390/ijerph16101736DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6572709PMC
May 2019

The effects of trans-chalcone and chalcone 4 hydrate on the growth of Babesia and Theileria.

PLoS Negl Trop Dis 2019 05 24;13(5):e0007030. Epub 2019 May 24.

National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido, Japan.

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http://dx.plos.org/10.1371/journal.pntd.0007030
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http://dx.doi.org/10.1371/journal.pntd.0007030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6534319PMC
May 2019

Ellagic acid microspheres restrict the growth of Babesia and Theileria in vitro and Babesia microti in vivo.

Parasit Vectors 2019 May 28;12(1):269. Epub 2019 May 28.

National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Nishi 2-13 Inada-cho, Obihiro, Hokkaido, 080-8555, Japan.

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http://dx.doi.org/10.1186/s13071-019-3520-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6537213PMC
May 2019

Development of unstable resistance to diminazene aceturate in Babesia bovis.

Int J Parasitol Drugs Drug Resist 2019 04 13;9:87-92. Epub 2019 Feb 13.

National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Inada-cho, Obihiro, Hokkaido, 080-8555, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.ijpddr.2019.02.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6382846PMC
April 2019

Evaluation of the in vitro and in vivo inhibitory effect of thymoquinone on piroplasm parasites.

Parasit Vectors 2019 Jan 16;12(1):37. Epub 2019 Jan 16.

National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Inada-Cho, Obihiro, Hokkaido, Japan.

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http://dx.doi.org/10.1186/s13071-019-3296-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6335684PMC
January 2019

Serological and molecular prevalence of equine piroplasmosis in Western Java, Indonesia.

Vet Parasitol Reg Stud Reports 2018 12 31;14:1-6. Epub 2018 Jul 31.

National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Nishi 2-13 Inada-cho, Obihiro, Hokkaido 080-8555, Japan. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S24059390183006
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http://dx.doi.org/10.1016/j.vprsr.2018.07.009DOI Listing
December 2018

Inhibitory effects of fluoroquinolone antibiotics on and , blood parasites of veterinary and zoonotic importance.

Infect Drug Resist 2018 28;11:1605-1615. Epub 2018 Sep 28.

National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Inada-Cho, Obihiro, Hokkaido, Japan,

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https://www.dovepress.com/inhibitory-effects-of-fluoroquinol
Publisher Site
http://dx.doi.org/10.2147/IDR.S159519DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6166754PMC
September 2018

Serosurvey of Babesia bovis and Babesia bigemina in cattle in Mongolia.

Vet Parasitol Reg Stud Reports 2018 08 16;13:85-91. Epub 2018 Apr 16.

National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Inada-cho, Obihiro, Hokkaido 080-8555, Japan. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S24059390173023
Publisher Site
http://dx.doi.org/10.1016/j.vprsr.2018.04.003DOI Listing
August 2018

Serological and molecular detection of Theileria equi and Babesia caballi in Philippine horses.

Ticks Tick Borne Dis 2018 07 18;9(5):1125-1128. Epub 2018 Apr 18.

National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido 080-8555, Japan. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S1877959X173038
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http://dx.doi.org/10.1016/j.ttbdis.2018.04.010DOI Listing
July 2018

The effects of nitidine chloride and camptothecin on the growth of Babesia and Theileria parasites.

Ticks Tick Borne Dis 2018 07 27;9(5):1192-1201. Epub 2018 Apr 27.

National Research Center for Protozoan Diseases, Obihiro University of Agriculture Veterinary Medicine, Nishi 2 Sen-11, Inada-cho, Obihiro, Hokkaido 080-8555, Japan. Electronic address:

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https://www.researchgate.net/publication/262979477_Evaluatio
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https://linkinghub.elsevier.com/retrieve/pii/S1877959X173058
Publisher Site
http://dx.doi.org/10.1016/j.ttbdis.2018.04.019DOI Listing
July 2018

Epidemiological survey of a cervine Theileria in wild deer, questing ticks, and cattle in Hokkaido, Japan.

Ticks Tick Borne Dis 2018 07 4;9(5):1235-1240. Epub 2018 May 4.

National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Inada-cho, Obihiro, Hokkaido 080-8555, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.ttbdis.2018.05.006DOI Listing
July 2018

Transovarial persistence of Babesia ovata DNA in a hard tick, Haemaphysalis longicornis, in a semi-artificial mouse skin membrane feeding system.

Acta Parasitol 2018 06;63(2):433

National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Inada-Cho, Obihiro, Hokkaido 080-8555, Japan.

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http://dx.doi.org/10.1515/ap-2018-0051DOI Listing
June 2018

17-DMAG inhibits the multiplication of several Babesia species and Theileria equi on in vitro cultures, and Babesia microti in mice.

Int J Parasitol Drugs Drug Resist 2018 04 1;8(1):104-111. Epub 2018 Mar 1.

National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Nishi 2-13 Inada-cho, Obihiro 080-8555, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.ijpddr.2018.02.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6114103PMC
April 2018

Serological and molecular surveys of Babesia bovis and Babesia bigemina among native cattle and cattle imported from Thailand in Hue, Vietnam.

J Vet Med Sci 2018 Mar 15;80(2):333-336. Epub 2017 Dec 15.

National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Inada-cho, Obihiro, Hokkaido 080-8555, Japan.

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http://dx.doi.org/10.1292/jvms.17-0549DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5836773PMC
March 2018

Molecular identification and antigenic characterization of Babesia divergens Erythrocyte Binding Protein (BdEBP) as a potential vaccine candidate.

Parasitol Int 2017 Dec 22;66(6):721-726. Epub 2017 Jul 22.

National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Inada-Cho, Obihiro, Hokkaido, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.parint.2017.07.004DOI Listing
December 2017

Molecular and serological detection of bovine babesiosis in Indonesia.

Parasit Vectors 2017 Nov 6;10(1):550. Epub 2017 Nov 6.

National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Nishi 2-13 Inada-cho, Obihiro, 080-8555, Japan.

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http://dx.doi.org/10.1186/s13071-017-2502-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5674684PMC
November 2017

Babesia bovis BOV57, a Theileria parva P67 homolog, is an invasion-related, neutralization-sensitive antigen.

Infect Genet Evol 2017 10 28;54:138-145. Epub 2017 Jun 28.

National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido 080-8555, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.meegid.2017.06.025DOI Listing
October 2017

Performance and consistency of a fluorescence-based high-throughput screening assay for use in Babesia drug screening in mice.

Sci Rep 2017 10 16;7(1):12774. Epub 2017 Oct 16.

National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Inada-Cho, Obihiro, Hokkaido, 080-8555, Japan.

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http://dx.doi.org/10.1038/s41598-017-13052-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5643553PMC
October 2017

Evaluation of the inhibitory effect of N-acetyl-L-cysteine on Babesia and Theileria parasites.

Exp Parasitol 2017 Aug 24;179:43-48. Epub 2017 Jun 24.

National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Inada-Cho, Obihiro, Hokkaido, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.exppara.2017.06.003DOI Listing
August 2017

Effects of dihydroorotate dehydrogenase (DHODH) inhibitors on the growth of Theileria equi and Babesia caballi in vitro.

Exp Parasitol 2017 May 9;176:59-65. Epub 2017 Mar 9.

National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido, 080-8555, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.exppara.2017.03.002DOI Listing
May 2017

Seroprevalence of Babesia bovis, B. bigemina, Trypanosoma evansi, and Anaplasma marginale antibodies in cattle in southern Egypt.

Ticks Tick Borne Dis 2017 01 20;8(1):125-131. Epub 2016 Oct 20.

National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Inada-cho, Obihiro, Hokkaido 080-8555, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.ttbdis.2016.10.008DOI Listing
January 2017

Expression of truncated Babesia microti apical membrane protein 1 and rhoptry neck protein 2 and evaluation of their protective efficacy.

Exp Parasitol 2017 Jan 19;172:5-11. Epub 2016 Nov 19.

National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Inada-cho, Obihiro, Hokkaido 080-8555, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.exppara.2016.11.001DOI Listing
January 2017

A longitudinal study of Babesia and Theileria infections in cattle in Sri Lanka.

Vet Parasitol Reg Stud Reports 2016 Dec 5;6:20-27. Epub 2016 Dec 5.

National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Inada-cho, Obihiro, Hokkaido 080-8555, Japan. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S24059390163012
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http://dx.doi.org/10.1016/j.vprsr.2016.11.009DOI Listing
December 2016

Establishment of a novel tick-Babesia experimental infection model.

Sci Rep 2016 11 14;6:37039. Epub 2016 Nov 14.

Laboratory of Infectious Diseases, Joint Faculty of Veterinary Medicine, Kagoshima University, Korimoto, Kagoshima 890-0065, Japan.

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http://dx.doi.org/10.1038/srep37039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5107930PMC
November 2016

Primary Babesia rodhaini infection followed by recovery confers protective immunity against B. rodhaini reinfection and Babesia microti challenge infection in mice.

Exp Parasitol 2016 Oct 14;169:6-12. Epub 2016 Jul 14.

National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Inada-cho, Obihiro, Hokkaido, 080-8555, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.exppara.2016.07.003DOI Listing
October 2016

Babesia ovata: Taxonomy, phylogeny and epidemiology.

Vet Parasitol 2016 Oct 4;229:99-106. Epub 2016 Oct 4.

National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Inada-cho, Obihiro, Hokkaido 080-8555, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.vetpar.2016.10.006DOI Listing
October 2016

Epidemiology of bovine hemoprotozoa parasites in cattle and water buffalo in Vietnam.

J Vet Med Sci 2016 Sep 28;78(8):1361-7. Epub 2016 Apr 28.

National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Inada-cho, Obihiro, Hokkaido 080-8555, Japan.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5053943PMC
http://dx.doi.org/10.1292/jvms.16-0099DOI Listing
September 2016

Recombinant methionine aminopeptidase protein of Babesia microti: immunobiochemical characterization as a vaccine candidate against human babesiosis.

Parasitol Res 2016 Sep 15;115(9):3669-76. Epub 2016 Jun 15.

National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Inada-cho, Obihiro, Hokkaido, 080-8555, Japan.

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http://dx.doi.org/10.1007/s00436-016-5172-5DOI Listing
September 2016

Large-scale drug screening against Babesia divergens parasite using a fluorescence-based high-throughput screening assay.

Vet Parasitol 2016 Aug 30;227:93-7. Epub 2016 Jul 30.

National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Inada-Cho, Obihiro, Hokkaido, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.vetpar.2016.07.032DOI Listing
August 2016

RBC invasion and invasion-inhibition assays using free merozoites isolated after cold treatment of Babesia bovis in vitro culture.

Exp Parasitol 2016 Jul 8;166:10-5. Epub 2016 Mar 8.

National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Inada-cho, Obihiro, Hokkaido 080-8555, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.exppara.2016.03.010DOI Listing
July 2016

Identification and characterization of profilin antigen among Babesia species as a common vaccine candidate against babesiosis.

Exp Parasitol 2016 Jul 19;166:29-36. Epub 2016 Mar 19.

National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Inada-cho, Obihiro, Hokkaido, 080-8555, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.exppara.2016.03.024DOI Listing
July 2016

Genetic diversity and antigenicity variation of Babesia bovis merozoite surface antigen-1 (MSA-1) in Thailand.

Infect Genet Evol 2016 07 19;41:255-261. Epub 2016 Apr 19.

National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido 080-8555, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.meegid.2016.04.021DOI Listing
July 2016

Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond.

Authors:
Wesley C Van Voorhis John H Adams Roberto Adelfio Vida Ahyong Myles H Akabas Pietro Alano Aintzane Alday Yesmalie Alemán Resto Aishah Alsibaee Ainhoa Alzualde Katherine T Andrews Simon V Avery Vicky M Avery Lawrence Ayong Mark Baker Stephen Baker Choukri Ben Mamoun Sangeeta Bhatia Quentin Bickle Lotfi Bounaadja Tana Bowling Jürgen Bosch Lauren E Boucher Fabrice F Boyom Jose Brea Marian Brennan Audrey Burton Conor R Caffrey Grazia Camarda Manuela Carrasquilla Dee Carter Maria Belen Cassera Ken Chih-Chien Cheng Worathad Chindaudomsate Anthony Chubb Beatrice L Colon Daisy D Colón-López Yolanda Corbett Gregory J Crowther Noemi Cowan Sarah D'Alessandro Na Le Dang Michael Delves Joseph L DeRisi Alan Y Du Sandra Duffy Shimaa Abd El-Salam El-Sayed Michael T Ferdig José A Fernández Robledo David A Fidock Isabelle Florent Patrick V T Fokou Ani Galstian Francisco Javier Gamo Suzanne Gokool Ben Gold Todd Golub Gregory M Goldgof Rajarshi Guha W Armand Guiguemde Nil Gural R Kiplin Guy Michael A E Hansen Kirsten K Hanson Andrew Hemphill Rob Hooft van Huijsduijnen Takaaki Horii Paul Horrocks Tyler B Hughes Christopher Huston Ikuo Igarashi Katrin Ingram-Sieber Maurice A Itoe Ajit Jadhav Amornrat Naranuntarat Jensen Laran T Jensen Rays H Y Jiang Annette Kaiser Jennifer Keiser Thomas Ketas Sebastien Kicka Sunyoung Kim Kiaran Kirk Vidya P Kumar Dennis E Kyle Maria Jose Lafuente Scott Landfear Nathan Lee Sukjun Lee Adele M Lehane Fengwu Li David Little Liqiong Liu Manuel Llinás Maria I Loza Aristea Lubar Leonardo Lucantoni Isabelle Lucet Louis Maes Dalu Mancama Nuha R Mansour Sandra March Sheena McGowan Iset Medina Vera Stephan Meister Luke Mercer Jordi Mestres Alvine N Mfopa Raj N Misra Seunghyun Moon John P Moore Francielly Morais Rodrigues da Costa Joachim Müller Arantza Muriana Stephen Nakazawa Hewitt Bakela Nare Carl Nathan Nathalie Narraidoo Sujeevi Nawaratna Kayode K Ojo Diana Ortiz Gordana Panic George Papadatos Silvia Parapini Kailash Patra Ngoc Pham Sarah Prats David M Plouffe Sally-Ann Poulsen Anupam Pradhan Celia Quevedo Ronald J Quinn Christopher A Rice Mohamed Abdo Rizk Andrea Ruecker Robert St Onge Rafaela Salgado Ferreira Jasmeet Samra Natalie G Robinett Ulrich Schlecht Marjorie Schmitt Filipe Silva Villela Francesco Silvestrini Robert Sinden Dennis A Smith Thierry Soldati Andreas Spitzmüller Serge Maximilian Stamm David J Sullivan William Sullivan Sundari Suresh Brian M Suzuki Yo Suzuki S Joshua Swamidass Donatella Taramelli Lauve R Y Tchokouaha Anjo Theron David Thomas Kathryn F Tonissen Simon Townson Abhai K Tripathi Valentin Trofimov Kenneth O Udenze Imran Ullah Cindy Vallieres Edgar Vigil Joseph M Vinetz Phat Voong Vinh Hoan Vu Nao-Aki Watanabe Kate Weatherby Pamela M White Andrew F Wilks Elizabeth A Winzeler Edward Wojcik Melanie Wree Wesley Wu Naoaki Yokoyama Paul H A Zollo Nada Abla Benjamin Blasco Jeremy Burrows Benoît Laleu Didier Leroy Thomas Spangenberg Timothy Wells Paul A Willis

PLoS Pathog 2016 07 28;12(7):e1005763. Epub 2016 Jul 28.

Medicines for Malaria Venture, Geneva, Switzerland.

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http://dx.doi.org/10.1371/journal.ppat.1005763DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4965013PMC
July 2016

Clofazimine Inhibits the Growth of Babesia and Theileria Parasites In Vitro and In Vivo.

Antimicrob Agents Chemother 2016 05 22;60(5):2739-46. Epub 2016 Apr 22.

National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido, Japan

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http://dx.doi.org/10.1128/AAC.01614-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4862543PMC
May 2016

Molecular and biochemical characterization of methionine aminopeptidase of Babesia bovis as a potent drug target.

Vet Parasitol 2016 May 27;221:14-23. Epub 2016 Feb 27.

National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Inada-cho, Obihiro, Hokkaido 080-8555, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.vetpar.2016.02.024DOI Listing
May 2016

Evaluation of in vitro inhibitory effect of enoxacin on Babesia and Theileria parasites.

Exp Parasitol 2016 Feb 25;161:62-7. Epub 2015 Dec 25.

National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Inada-Cho, Obihiro, Hokkaido, Japan.

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http://dx.doi.org/10.1016/j.exppara.2015.12.016DOI Listing
February 2016

Type-specific PCR assays for Babesia bovis msa-1 genotypes in Asia: Revisiting the genetic diversity in Sri Lanka, Mongolia, and Vietnam.

Infect Genet Evol 2016 Jan 29;37:64-9. Epub 2015 Oct 29.

National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.meegid.2015.10.029DOI Listing
January 2016

Seroprevalence of antibody to TgGRA7 antigen of Toxoplasma gondii in livestock animals from Western Java, Indonesia.

Parasitol Int 2015 Dec 18;64(6):484-6. Epub 2015 Jul 18.

National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Nishi 2-13 Inada-cho, Obihiro 080-8555, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.parint.2015.07.004DOI Listing
December 2015

The PCR detection and phylogenetic characterization of Babesia microti in questing ticks in Mongolia.

Parasitol Int 2015 Dec 28;64(6):527-32. Epub 2015 Jul 28.

National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Inada-cho, Obihiro, Hokkaido 080-8555, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.parint.2015.07.007DOI Listing
December 2015

Molecular Characterization of Babesia bovis M17 Leucine Aminopeptidase and Inhibition of Babesia Growth by Bestatin.

J Parasitol 2015 Oct 9;101(5):536-41. Epub 2015 Jun 9.

National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Inada-cho, Obihiro, Hokkaido 080-8555, Japan.

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http://dx.doi.org/10.1645/15-745.1DOI Listing
October 2015

An epidemiological survey of bovine Babesia and Theileria parasites in cattle, buffaloes, and sheep in Egypt.

Parasitol Int 2015 Feb 14;64(1):79-85. Epub 2014 Oct 14.

National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Inada-cho, Obihiro, Hokkaido 080-8555, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.parint.2014.10.002DOI Listing
February 2015

DB-AT: a 2015 update to the Full-parasites database brings a multitude of new transcriptomic data for apicomplexan parasites.

Nucleic Acids Res 2015 Jan 20;43(Database issue):D631-6. Epub 2014 Nov 20.

Division of Collaboration and Education, Research Center for Zoonosis Control, Hokkaido University, North 20, West 10 Kita-ku, Sapporo, Hokkaido 001-0020, Japan Global Station for Zoonosis Control, GI-CoRE, Hokkaido University, North 20, West 10 Kita-ku, Sapporo, Hokkaido 001-0020, Japan

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http://nar.oxfordjournals.org/content/43/D1/D631.full.pdf
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http://eprints.lib.hokudai.ac.jp/dspace/bitstream/2115/58557
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http://nar.oxfordjournals.org/lookup/doi/10.1093/nar/gku1240
Publisher Site
http://dx.doi.org/10.1093/nar/gku1240DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4383994PMC
January 2015

Seroprevalence and risk factors associated with exposure of water buffalo (Bubalus bubalis) to Neospora caninum in northeast Thailand.

Vet Parasitol 2015 Jan 27;207(1-2):156-60. Epub 2014 Nov 27.

University of Missouri, Department of Veterinary Pathobiology, 201 Connaway Hall, Columbia, MO 65211, USA.

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http://dx.doi.org/10.1016/j.vetpar.2014.10.034DOI Listing
January 2015

Genetic diversity in Trypanosoma theileri from Sri Lankan cattle and water buffaloes.

Vet Parasitol 2015 Jan 19;207(3-4):335-41. Epub 2014 Dec 19.

National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Hokkaido, Japan.

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http://dx.doi.org/10.1016/j.vetpar.2014.12.006DOI Listing
January 2015

Generation of monoclonal autoantibodies from Babesia rodhaini-infected mice.

J Vet Med Sci 2014 Sep 9;76(9):1281-4. Epub 2014 Jun 9.

United Graduate School of Veterinary Science, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4197159PMC
http://dx.doi.org/10.1292/jvms.14-0095DOI Listing
September 2014

Mycophenolic acid, mycophenolate mofetil, mizoribine, ribavirin, and 7-nitroindole inhibit propagation of Babesia parasites by targeting inosine 5'-monophosphate dehydrogenase.

J Parasitol 2014 Aug 28;100(4):522-6. Epub 2014 Feb 28.

National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Inada-cho, Obihiro, Hokkaido 080-8555, Japan;

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http://dx.doi.org/10.1645/13-278.1DOI Listing
August 2014

Evaluation of the inhibitory effects of miltefosine on the growth of Babesia and Theileria parasites.

Vet Parasitol 2014 Aug 23;204(3-4):104-10. Epub 2014 May 23.

National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Inada-cho, Obihiro, Hokkaido 080-8555, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.vetpar.2014.05.023DOI Listing
August 2014

The Babesia bovis gene and promoter model: an update from full-length EST analysis.

BMC Genomics 2014 Aug 13;15:678. Epub 2014 Aug 13.

National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Inada-cho west 2-13, Obihiro, Hokkaido 080-8555, Japan.

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http://dx.doi.org/10.1186/1471-2164-15-678DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4148916PMC
August 2014

Identification and characterization of a Trypanosoma congolense 46 kDa protein as a candidate serodiagnostic antigen.

J Vet Med Sci 2014 Jun 3;76(6):799-806. Epub 2014 Feb 3.

National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Inada, Obihiro, Hokkaido 080-8555, Japan.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4108761PMC
http://dx.doi.org/10.1292/jvms.13-0462DOI Listing
June 2014

Seroprevalence of Neospora caninum infection in dairy cows in Northern provinces, Thailand.

Acta Parasitol 2014 Jun 15;59(2):305-9. Epub 2014 May 15.

National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Inada-cho, Obihiro, Hokkaido, 080-8555, Japan,

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http://dx.doi.org/10.2478/s11686-014-0245-zDOI Listing
June 2014

Epidemiological investigation of equine piroplasmosis in China by enzyme-linked immunosorbent assays.

J Vet Med Sci 2014 Apr 29;76(4):549-52. Epub 2013 Nov 29.

Harbin Veterinary Research Institute-Michigan State University Joint Laboratory of Innate Immunity & State Key Laboratory of Veterinary Biotechnology, Chinese Academy of Agricultural Sciences, Maduan Street 427, Nangang District, Harbin 150001, P. R. China.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4064140PMC
http://dx.doi.org/10.1292/jvms.13-0477DOI Listing
April 2014

PCR detection of Babesia ovata from questing ticks in Japan.

Ticks Tick Borne Dis 2014 Apr 23;5(3):305-10. Epub 2014 Feb 23.

National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Hokkaido 080-8555, Japan. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S1877959X140002
Publisher Site
http://dx.doi.org/10.1016/j.ttbdis.2013.12.006DOI Listing
April 2014

Babesia bovis dihydroorotate dehydrogenase (BboDHODH) is a novel molecular target of drug for bovine babesiosis.

J Vet Med Sci 2014 Mar 1;76(3):323-30. Epub 2013 Nov 1.

National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido 080-8555, Japan.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4013357PMC
http://dx.doi.org/10.1292/jvms.13-0419DOI Listing
March 2014

Diversity of Babesia bovis merozoite surface antigen genes in the Philippines.

Parasitol Int 2014 Feb 14;63(1):57-63. Epub 2013 Sep 14.

National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido 080-8555, Japan.

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http://dx.doi.org/10.1016/j.parint.2013.09.003DOI Listing
February 2014

Inhibitory effect of allicin on the growth of Babesia and Theileria equi parasites.

Parasitol Res 2014 Jan 31;113(1):275-83. Epub 2013 Oct 31.

National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Inada-cho, Obihiro, Hokkaido, 080-8555, Japan.

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http://dx.doi.org/10.1007/s00436-013-3654-2DOI Listing
January 2014

The genetic diversity of merozoite surface antigen 1 (MSA-1) among Babesia bovis detected from cattle populations in Thailand, Brazil and Ghana.

J Vet Med Sci 2013 Nov 12;75(11):1463-70. Epub 2013 Jul 12.

National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Inada-cho, Obihiro, Hokkaido 080-8555, Japan.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3942984PMC
http://dx.doi.org/10.1292/jvms.13-0251DOI Listing
November 2013

PCR detection and genetic diversity of bovine hemoprotozoan parasites in Vietnam.

J Vet Med Sci 2013 Nov 12;75(11):1455-62. Epub 2013 Jul 12.

National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Inada-Cho, Obihiro, Hokkaido 080-8555, Japan.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3942975PMC
http://dx.doi.org/10.1292/jvms.13-0221DOI Listing
November 2013

The molecular prevalence and MSA-2b gene-based genetic diversity of Babesia bovis in dairy cattle in Thailand.

Vet Parasitol 2013 Nov 18;197(3-4):642-8. Epub 2013 Jul 18.

Center for Agricultural Biotechnology, Kasetsart University, Kamphaeng Saen Campus, Nakhon Pathom 73140, Thailand; Center of Excellence on Agricultural Biotechnology (AG-BIO/PERDO-CHE), Bangkok 10900, Thailand; Center for Advanced Studies for Agriculture and Food, Kasetsart University Institute for Advanced Studies, Kasetsart University (CASAF, NRU-KU, Thailand), Bangkok 10900, Thailand; Department of Parasitology, Faculty of Veterinary Medicine, Kasetsart University, Bangkok 10900, Thailand.

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http://dx.doi.org/10.1016/j.vetpar.2013.07.015DOI Listing
November 2013

Specific antibody to a conserved region of Babesia apical membrane antigen-1 inhibited the invasion of B. bovis into the erythrocyte.

Exp Parasitol 2013 Nov 30;135(3):623-8. Epub 2013 Sep 30.

National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Inada-Cho, Obihiro, Hokkaido 080-8555, Japan; Department of Animal Medicine and Infectious Diseases, Faculty of Veterinary Medicine, University of Sadat City, Minoufiya 32897, Egypt.

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http://dx.doi.org/10.1016/j.exppara.2013.09.017DOI Listing
November 2013

Genetic diversity of merozoite surface antigens in Babesia bovis detected from Sri Lankan cattle.

Infect Genet Evol 2013 Oct 10;19:134-40. Epub 2013 Jul 10.

National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Hokkaido, Japan; Veterinary Research Institute, Peradeniya, Sri Lanka.

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http://dx.doi.org/10.1016/j.meegid.2013.07.001DOI Listing
October 2013

Prevalence and genetic diversity of equine piroplasms in Tov province, Mongolia.

Infect Genet Evol 2013 Jun 14;16:178-85. Epub 2013 Feb 14.

National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido 080-8555, Japan.

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http://dx.doi.org/10.1016/j.meegid.2013.02.005DOI Listing
June 2013

Genetic diversity within Theileria orientalis parasites detected in Sri Lankan cattle.

Ticks Tick Borne Dis 2013 Apr 18;4(3):235-41. Epub 2013 Jan 18.

National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Hokkaido 080-8555, Japan.

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http://dx.doi.org/10.1016/j.ttbdis.2012.11.009DOI Listing
April 2013

Identification and characterization of an interspersed repeat antigen of Babesia microti (BmIRA).

Exp Parasitol 2013 Mar 3;133(3):346-52. Epub 2013 Jan 3.

National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Inada-cho, Obihiro, Hokkaido 080-8555, Japan.

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http://dx.doi.org/10.1016/j.exppara.2012.12.015DOI Listing
March 2013