Ikumi Tamai

Ikumi Tamai

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Ikumi Tamai

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ABCG2 requires a single aromatic amino acid to "clamp" substrates and inhibitors into the binding pocket.

FASEB J 2020 Apr 17;34(4):4890-4903. Epub 2020 Feb 17.

Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, TN, USA.

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http://dx.doi.org/10.1096/fj.201902338RRDOI Listing
April 2020

Identification of the Uptake Transporter Responsible for Distribution of Acotiamide into Stomach Tissue.

Mol Pharm 2020 Apr 10;17(4):1071-1078. Epub 2020 Mar 10.

Institute of Medical Pharmaceutical and Health Sciences, Faculty of Pharmacy, Kanazawa University, Kanazawa 920-1192, Japan.

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http://dx.doi.org/10.1021/acs.molpharmaceut.9b00894DOI Listing
April 2020

Changes of drug pharmacokinetics mediated by downregulation of kidney organic cation transporters Mate1 and Oct2 in a rat model of hyperuricemia.

PLoS One 2019 5;14(4):e0214862. Epub 2019 Apr 5.

Faculty of Pharmaceutical Sciences, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0214862PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6450621PMC
January 2020

Transport mechanism and affinity of [99mTc]Tc-mercaptoacetyltriglycine ([99mTc]MAG3) on the apical membrane of renal proximal tubule cells.

Nucl Med Biol 2020 May - Jun;84-85:33-37. Epub 2020 Jan 15.

School of Health Sciences, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Ishikawa, Japan; Biomedical Imaging Research Center, University of Fukui, Fukui, Japan.

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http://dx.doi.org/10.1016/j.nucmedbio.2020.01.002DOI Listing
January 2020

Author Correction: Imaging of hepatic drug transporters with [I]6-β-iodomethyl-19-norcholesterol.

Sci Rep 2019 Dec 6;9(1):18478. Epub 2019 Dec 6.

School of Health Sciences, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Ishikawa, Japan.

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http://dx.doi.org/10.1038/s41598-019-54992-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6897956PMC
December 2019

Imaging of hepatic drug transporters with [I]6-β-iodomethyl-19-norcholesterol.

Sci Rep 2019 09 16;9(1):13413. Epub 2019 Sep 16.

School of Health Sciences, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Ishikawa, Japan.

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http://dx.doi.org/10.1038/s41598-019-50049-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6746803PMC
September 2019

In vivo hepatic clearance of lipophilic drugs predicted by in vitro uptake data into cryopreserved hepatocytes suspended in sera of rats, guinea pigs, monkeys and humans.

Xenobiotica 2019 Aug 21;49(8):887-894. Epub 2018 Sep 21.

c Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University , Kanazawa , Japan.

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http://dx.doi.org/10.1080/00498254.2018.1514476DOI Listing
August 2019

Rat Kidney Slices for Evaluation of Apical Membrane Transporters in Proximal Tubular Cells.

J Pharm Sci 2019 08 5;108(8):2798-2804. Epub 2019 Apr 5.

Faculty of Pharmaceutical Sciences, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.xphs.2019.03.031DOI Listing
August 2019

Identification of the Catechin Uptake Transporter Responsible for Intestinal Absorption of Epigallocatechin Gallate in Mice.

Sci Rep 2019 07 29;9(1):11014. Epub 2019 Jul 29.

Faculty of Pharmaceutical Sciences, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan.

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http://dx.doi.org/10.1038/s41598-019-47214-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6662683PMC
July 2019

Uric acid analogue as a possible xenobiotic marker of uric acid transporter Urat1 in rats.

Drug Metab Pharmacokinet 2019 Apr 27;34(2):155-158. Epub 2018 Dec 27.

Department of Membrane Transport and Biopharmaceutics, Faculty of Pharmaceutical Sciences, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kakuma-machi, Kanazawa 920-1192, Japan. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S13474367183014
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http://dx.doi.org/10.1016/j.dmpk.2018.12.003DOI Listing
April 2019

Foreword.

Biol Pharm Bull 2018;41(9):1322-1323

Faculty of Pharma-Sciences, Teikyo University.

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http://dx.doi.org/10.1248/bpb.b18-ctf4109DOI Listing
February 2019

Experimental Evidence for Resecretion of PGE across Rat Alveolar Epithelium by OATP2A1/S-Mediated Transcellular Transport.

J Pharmacol Exp Ther 2019 02 12;368(2):317-325. Epub 2018 Nov 12.

Faculty of Pharmaceutical Sciences, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan.

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http://jpet.aspetjournals.org/lookup/doi/10.1124/jpet.118.24
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http://dx.doi.org/10.1124/jpet.118.249789DOI Listing
February 2019

Effect of endogenous multidrug resistance 1 and P-glycoprotein expression on anticancer drug resistance in colon cancer cell lines.

Biopharm Drug Dispos 2019 Jan 4;40(1):32-43. Epub 2019 Jan 4.

Faculty of Pharmaceutical Sciences, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan.

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http://dx.doi.org/10.1002/bdd.2167DOI Listing
January 2019

Apple-Derived Nanoparticles Modulate Expression of Organic-Anion-Transporting Polypeptide (OATP) 2B1 in Caco-2 Cells.

Mol Pharm 2018 12 5;15(12):5772-5780. Epub 2018 Nov 5.

Faculty of Pharmaceutical Sciences, Institute of Medical, Pharmaceutical and Health Sciences , Kanazawa University , Kakuma-machi, Kanazawa 920-1192 , Japan.

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http://pubs.acs.org/doi/10.1021/acs.molpharmaceut.8b00921
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http://dx.doi.org/10.1021/acs.molpharmaceut.8b00921DOI Listing
December 2018

Membrane Transporters Contributing to PGE Distribution in Central Nervous System.

Biol Pharm Bull 2018 ;41(9):1337-1347

Faculty of Pharmaceutical Sciences, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University.

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https://www.jstage.jst.go.jp/article/bpb/41/9/41_b18-00169/_
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http://dx.doi.org/10.1248/bpb.b18-00169DOI Listing
November 2018

Different Efflux Transporter Affinity and Metabolism of Tc-2-Methoxyisobutylisonitrile and Tc-Tetrofosmin for Multidrug Resistance Monitoring in Cancer.

Pharm Res 2018 Nov 29;36(1):18. Epub 2018 Nov 29.

School of Health Sciences, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan.

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http://dx.doi.org/10.1007/s11095-018-2548-5DOI Listing
November 2018

Cyclophosphamide-induced hemorrhagic cystitis in young patients with solid tumors: A single institution study.

Asia Pac J Clin Oncol 2018 Oct 10;14(5):e460-e464. Epub 2018 Jul 10.

Department of Pharmacy, National Cancer Center Hospital, Tokyo, Japan.

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http://dx.doi.org/10.1111/ajco.13048DOI Listing
October 2018

Prostaglandin Transporter OATP2A1/ Is Essential for Body Temperature Regulation during Fever.

J Neurosci 2018 06 21;38(24):5584-5595. Epub 2018 May 21.

Faculty of Pharmaceutical Sciences, Institute of Medical, Pharmaceutical, and Health Sciences, Kanazawa University, Kanazawa 920-1192, Japan.

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http://dx.doi.org/10.1523/JNEUROSCI.3276-17.2018DOI Listing
June 2018

Effect of tyrosine kinase inhibitors on renal handling of creatinine by MATE1.

Sci Rep 2018 06 18;8(1):9237. Epub 2018 Jun 18.

Faculty of Pharmaceutical Science, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kakuma-machi, Kanazawa, 920-1192, Japan.

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http://dx.doi.org/10.1038/s41598-018-27672-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6006426PMC
June 2018

Hyperuricemia enhances intracellular urate accumulation via down-regulation of cell-surface BCRP/ABCG2 expression in vascular endothelial cells.

Biochim Biophys Acta Biomembr 2018 May 6;1860(5):973-980. Epub 2018 Jan 6.

Department of Membrane Transport and Biopharmaceutics, Faculty of Pharmaceutical Sciences, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kakuma-machi, Kanazawa 920-1192, Japan. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00052736183000
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http://dx.doi.org/10.1016/j.bbamem.2018.01.006DOI Listing
May 2018

Sandwich-Cultured Hepatocytes for Mechanistic Understanding of Hepatic Disposition of Parent Drugs and Metabolites by Transporter-Enzyme Interplay.

Drug Metab Dispos 2018 May 19;46(5):680-691. Epub 2018 Jan 19.

Pharmacokinetic Research Laboratories, Ono Pharmaceutical Co., Ltd., Tsukuba, Japan (N.M. Y.F., H.I.); Department of Membrane Transport and Biopharmaceutics, Faculty of Pharmaceutical Sciences, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan (I.T.)

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http://dx.doi.org/10.1124/dmd.117.079236DOI Listing
May 2018

Contribution of equilibrative nucleoside transporters 1 and 2 to gemcitabine uptake in pancreatic cancer cells.

Biopharm Drug Dispos 2018 May;39(5):256-264

Department of Clinical Pharmacokinetics, Graduate School of Medical Sciences, Kanazawa University, 13-1 Takara-machi, Kanazawa, 920-8641, Japan.

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http://dx.doi.org/10.1002/bdd.2131DOI Listing
May 2018

Impact of Breast Cancer Resistance Protein Expression on the In Vitro Efficacy of Anticancer Drugs in Pancreatic Cancer Cell Lines.

Drug Metab Dispos 2018 03 15;46(3):214-222. Epub 2017 Dec 15.

Faculty of Pharmaceutical Sciences, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan (I.W., T.N., I.T.); and Pharmacokinetics and Non-Clinical Safety Department, Nippon Boehringer Ingelheim Co. Ltd., Kobe, Japan (I.W., N.I., N.Y.)

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http://dx.doi.org/10.1124/dmd.117.078402DOI Listing
March 2018

Contribution of equilibrative nucleoside transporter(s) to intestinal basolateral and apical transports of anticancer trifluridine.

Biopharm Drug Dispos 2018 Jan 15;39(1):38-46. Epub 2017 Dec 15.

Faculty of Pharmaceutical Sciences, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kakuma-machi, Kanazawa, Japan.

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http://dx.doi.org/10.1002/bdd.2110DOI Listing
January 2018

Roles of Organic Anion Transporting Polypeptide 2A1 (OATP2A1/SLCO2A1) in Regulating the Pathophysiological Actions of Prostaglandins.

AAPS J 2017 12 4;20(1):13. Epub 2017 Dec 4.

Department of Membrane Transport and Biopharmaceutics, Faculty of Pharmaceutical Sciences, Kanazawa University, Kakuma-machi, Kanazawa, 920-1192, Japan.

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http://link.springer.com/10.1208/s12248-017-0163-8
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http://dx.doi.org/10.1208/s12248-017-0163-8DOI Listing
December 2017

Usefulness of kidney slices for functional analysis of apical reabsorptive transporters.

Sci Rep 2017 10 9;7(1):12814. Epub 2017 Oct 9.

Department of Membrane Transport of Biopharmaceutics, Faculty of Pharmaceutical Sciences, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kakuma-machi, Kanazawa, 920-1192, Japan.

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http://dx.doi.org/10.1038/s41598-017-12828-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5634478PMC
October 2017

Inhibitory Effect of Crizotinib on Creatinine Uptake by Renal Secretory Transporter OCT2.

J Pharm Sci 2017 09 21;106(9):2899-2903. Epub 2017 Mar 21.

Department of Membrane Transport of Biopharmaceutics, Faculty of Pharmaceutical Sciences, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kakuma-machi, Kanazawa 920-1192, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.xphs.2017.03.013DOI Listing
September 2017

Association of miR-145 With Statin-Induced Skeletal Muscle Toxicity in Human Rhabdomyosarcoma RD Cells.

J Pharm Sci 2017 09 21;106(9):2873-2880. Epub 2017 Apr 21.

Department of Membrane Transport and Biopharmaceutics, and Drug Metabolism and Toxicology, Faculty of Pharmaceutical Sciences, Kanazawa University, Kakuma-machi, Kanazawa 920-1192, Japan. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00223549173023
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http://dx.doi.org/10.1016/j.xphs.2017.04.005DOI Listing
September 2017

Different Involvement of OAT in Renal Disposition of Oral Anticoagulants Rivaroxaban, Dabigatran, and Apixaban.

J Pharm Sci 2017 09 26;106(9):2524-2534. Epub 2017 Apr 26.

Institute of Medical, Pharmaceutical and Health Sciences, Faculty of Pharmaceutical Sciences, Kanazawa University, Kanazawa, Japan.

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https://linkinghub.elsevier.com/retrieve/pii/S00223549173028
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http://dx.doi.org/10.1016/j.xphs.2017.04.044DOI Listing
September 2017

Impact of FDA-Approved Drugs on the Prostaglandin Transporter OATP2A1/SLCO2A1.

J Pharm Sci 2017 09 4;106(9):2483-2490. Epub 2017 May 4.

Department of Membrane Transport and Biopharmaceutics, Faculty of Pharmaceutical Sciences, Kanazawa University, Kakuma-machi, Kanazawa 920-1192, Japan.

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http://dx.doi.org/10.1016/j.xphs.2017.04.046DOI Listing
September 2017

Co-localization of microsomal prostaglandin E synthase-1 with cyclooxygenase-1 in layer II of murine placental syncytiotrophoblasts.

Placenta 2017 05 6;53:76-82. Epub 2017 Apr 6.

Faculty of Pharmacy, Keio University, 1-5-30 Shibakoen, Minato-ku, Tokyo 105-8512, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.placenta.2017.04.002DOI Listing
May 2017

Revisiting the role of gut wall in the fate of orally administered drugs: Why now and to what effect?

Biopharm Drug Dispos 2017 03;38(2):87-93

Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, Canada.

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http://dx.doi.org/10.1002/bdd.2071DOI Listing
March 2017

Impact of Organic Cation Transporters (OCT-SLC22A) on Differential Diagnosis of Intrahepatic Lesions.

Drug Metab Dispos 2017 02 30;45(2):166-173. Epub 2016 Nov 30.

Department of Clinical Pharmacology and Toxicology, University Hospital Zurich, University of Zurich, Switzerland (M.V., C.H., L.H., G.A. K.-U., B.S.); Department of Surgery, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands (B.V.v.R., M.B., T.M.v.G.); Department of Nuclear Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands (R.J.B.); Department of Radiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands (S.S.K.S.P.); Department of Pathology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands (J.V.); Department of Molecular Plant Physiology and Biophysics, Julius-von-Sachs-Institute, University of Würzburg, Germany (H.K.); and Faculty of Pharmaceutical Sciences, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Japan (I.T.)

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http://dx.doi.org/10.1124/dmd.116.072371DOI Listing
February 2017

Comparative Evaluation of Dehydroepiandrosterone Sulfate Potential to Predict Hepatic Organic Anion Transporting Polypeptide Transporter-Based Drug-Drug Interactions.

Drug Metab Dispos 2017 02 1;45(2):224-227. Epub 2016 Dec 1.

Faculty of Pharmaceutical Sciences, Institute of Medical, Pharmaceutical and Health Sciences University, Kanazawa, Japan

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http://dx.doi.org/10.1124/dmd.116.072355DOI Listing
February 2017

Interaction of Drug or Food with Drug Transporters in Intestine and Liver.

Curr Drug Metab 2015 ;16(9):753-64

Institute of Medical, Pharmaceutical and Health Sciences, Faculty of Pharmacy, Kanazawa University, Kakuma-machi, Kanazawa 920-1192, Japan.

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http://dx.doi.org/10.2174/138920021609151201113537DOI Listing
September 2016

Role of OATP2A1 in PGE(2) secretion from human colorectal cancer cells via exocytosis in response to oxidative stress.

Exp Cell Res 2016 Feb 2;341(2):123-31. Epub 2016 Feb 2.

Faculty of Pharmaceutical Science, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kakuma-machi, Kanazawa 920-1192, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.yexcr.2016.02.002DOI Listing
February 2016

Carrier-Mediated Prodrug Uptake to Improve the Oral Bioavailability of Polar Drugs: An Application to an Oseltamivir Analogue.

J Pharm Sci 2016 Feb;105(2):925-934

Department of Pharmaceutical Sciences, College of Pharmacy, University of Michigan, Ann Arbor, Michigan 48109. Electronic address:

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http://dx.doi.org/10.1016/j.xphs.2015.11.036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4857762PMC
February 2016

Prostaglandin Transporter (PGT/SLCO2A1) Protects the Lung from Bleomycin-Induced Fibrosis.

PLoS One 2015 29;10(4):e0123895. Epub 2015 Apr 29.

Faculty of Pharmaceutical Sciences, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0123895PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4414486PMC
January 2016

Local Drug-Drug Interaction of Donepezil with Cilostazol at Breast Cancer Resistance Protein (ABCG2) Increases Drug Accumulation in Heart.

Drug Metab Dispos 2016 Jan 14;44(1):68-74. Epub 2015 Oct 14.

Faculty of Pharmaceutical Sciences, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa (R.T., T.N., I.T.) and Hikuma Pharmacy, Hamamatsu (K.S.), Japan

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http://dx.doi.org/10.1124/dmd.115.066654DOI Listing
January 2016

Analysis of the Metabolic Pathway of Bosentan and of the Cytotoxicity of Bosentan Metabolites Based on a Quantitative Modeling of Metabolism and Transport in Sandwich-Cultured Human Hepatocytes.

Drug Metab Dispos 2016 Jan 26;44(1):16-27. Epub 2015 Oct 26.

Department of Membrane Transport and Biopharmaceutics, Faculty of Pharmaceutical Sciences, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan (N.M., A.Y.S., T.N., I.T.); and Pharmacokinetic Research Laboratories, Ono Pharmaceutical Co., Ltd., Tsukuba, Japan (N.M., N.K., K.N., H.I.)

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http://dx.doi.org/10.1124/dmd.115.067074DOI Listing
January 2016

Organic Anion Transporting Polypeptide (OATP)2B1 Contributes to Gastrointestinal Toxicity of Anticancer Drug SN-38, Active Metabolite of Irinotecan Hydrochloride.

Drug Metab Dispos 2016 Jan 2;44(1):1-7. Epub 2015 Nov 2.

Faculty of Pharmaceutical Sciences, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan (D.F., Y.S., T.N., I.T.), and Department of Pharmacy, National Cancer Center Hospital, Tokyo, Japan (Y.S.)

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http://dmd.aspetjournals.org/cgi/doi/10.1124/dmd.115.066712
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http://dx.doi.org/10.1124/dmd.115.066712DOI Listing
January 2016

Prostaglandin transporter (OATP2A1/SLCO2A1) contributes to local disposition of eicosapentaenoic acid-derived PGE3.

Prostaglandins Other Lipid Mediat 2016 Jan 10;122:10-7. Epub 2015 Dec 10.

Faculty of Pharmaceutical Sciences, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa 920-1192, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.prostaglandins.2015.12.003DOI Listing
January 2016

OATP2A1/SLCO2A1-mediated prostaglandin E2 loading into intracellular acidic compartments of macrophages contributes to exocytotic secretion.

Biochem Pharmacol 2015 Dec 22;98(4):629-38. Epub 2015 Oct 22.

Department of Membrane Transport and Biopharmaceutics, Faculty of Pharmaceutical Science, Kanazawa University, Kakuma-machi, Kanazawa 920-1192, Japan.

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http://dx.doi.org/10.1016/j.bcp.2015.10.009DOI Listing
December 2015

The change of pharmacokinetics of fexofenadine enantiomers through the single and simultaneous grapefruit juice ingestion.

Drug Metab Pharmacokinet 2015 Oct 26;30(5):352-7. Epub 2015 Jun 26.

Department of Pharmacy, Zikeikai-Aoimori Hospital, Aomori, Japan.

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http://dx.doi.org/10.1016/j.dmpk.2015.06.005DOI Listing
October 2015

Involvement of Concentrative Nucleoside Transporter 1 in Intestinal Absorption of Trifluridine Using Human Small Intestinal Epithelial Cells.

J Pharm Sci 2015 Sep 21;104(9):3146-53. Epub 2015 Apr 21.

Faculty of Pharmaceutical Sciences, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kakuma-machi, Kanazawa, Japan.

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http://dx.doi.org/10.1002/jps.24455DOI Listing
September 2015

Kinetic Evaluation of Determinant Factors for Cellular Accumulation of Protoporphyrin IX Induced by External 5-Aminolevulinic Acid for Photodynamic Cancer Therapy.

J Pharm Sci 2015 Sep 8;104(9):3092-100. Epub 2015 May 8.

Faculty of Pharmaceutical Sciences, Kanazawa University, Kakuma-machi, Kanazawa, 920-1192, Japan.

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http://dx.doi.org/10.1002/jps.24462DOI Listing
September 2015

Gordon L. Amidon: Very Sustained Drug Absorption.

J Pharm Sci 2015 Sep 5;104(9):2650-63. Epub 2015 Jun 5.

Food and Drug Administration, Rockville, Maryland.

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http://dx.doi.org/10.1002/jps.24523DOI Listing
September 2015

Organic anion transporting polypeptide 2B1 expression correlates with uptake of estrone-3-sulfate and cell proliferation in estrogen receptor-positive breast cancer cells.

Drug Metab Pharmacokinet 2015 Apr 14;30(2):133-41. Epub 2014 Nov 14.

Department of Clinical Pharmacology, Chiba University Graduate School of Pharmaceutical Sciences, Chiba, Japan; Division of Pharmacy, Chiba University Hospital, Chiba, Japan.

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http://dx.doi.org/10.1016/j.dmpk.2014.10.005DOI Listing
April 2015

Modeling approach for multiple transporters-mediated drug-drug interactions in sandwich-cultured human hepatocytes: effect of cyclosporin A on hepatic disposition of mycophenolic acid phenyl-glucuronide.

Drug Metab Pharmacokinet 2015 Apr 14;30(2):142-8. Epub 2014 Nov 14.

Department of Membrane Transport and Biopharmaceutics, Faculty of Pharmaceutical Sciences, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.dmpk.2014.10.006DOI Listing
April 2015

Dehydroepiandrosterone sulfate, a useful endogenous probe for evaluation of drug-drug interaction on hepatic organic anion transporting polypeptide (OATP) in cynomolgus monkeys.

Drug Metab Pharmacokinet 2015 Apr 6;30(2):198-204. Epub 2015 Jan 6.

Institute of Medical, Pharmaceutical and Health Sciences, Faculty of Pharmaceutical Sciences, Kanazawa University, Kanazawa, Japan.

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http://dx.doi.org/10.1016/j.dmpk.2014.12.009DOI Listing
April 2015

In-vitro evidence of enhanced breast cancer resistance protein-mediated intestinal urate secretion by uremic toxins in Caco-2 cells.

J Pharm Pharmacol 2015 Feb 17;67(2):170-7. Epub 2014 Dec 17.

Department of Membrane Transport and Biopharmaceutics, Faculty of Pharmaceutical Sciences, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan.

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http://dx.doi.org/10.1111/jphp.12328DOI Listing
February 2015

Putative roles of organic anion transporting polypeptides (OATPs) in cell survival and progression of human cancers.

Biopharm Drug Dispos 2014 Nov 13;35(8):463-84. Epub 2014 Oct 13.

Department of Membrane Transport and Biopharmaceutics, Faculty of Pharmaceutical Sciences, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kakuma-machi, Kanazawa, 920-1192, Japan.

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http://dx.doi.org/10.1002/bdd.1915DOI Listing
November 2014

More relevant prediction for in vivo drug interaction of candesartan cilexetil on hepatic bile acid transporter BSEP using sandwich-cultured hepatocytes.

Drug Metab Pharmacokinet 2014 23;29(1):94-6. Epub 2013 Jul 23.

Department of Membrane Transport and Biopharmaceutics, Faculty of Pharmaceutical Sciences, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University.

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http://dx.doi.org/10.2133/dmpk.dmpk-13-nt-049DOI Listing
October 2014

SGLT2 inhibitor lowers serum uric acid through alteration of uric acid transport activity in renal tubule by increased glycosuria.

Biopharm Drug Dispos 2014 Oct 6;35(7):391-404. Epub 2014 Aug 6.

Department of Membrane Transport and Biopharmaceutics, Faculty of Pharmaceutical Sciences, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kakuma-machi, Kanazawa, 920-1192, Japan; Drug Safety and Pharmacokinetics Laboratories, Taisho Pharmaceutical Co., Ltd, 1-403 Yoshino-cho, Kita-ku, Saitama, 331-9530, Japan.

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http://dx.doi.org/10.1002/bdd.1909DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4223977PMC
October 2014

How should we handle decreased efficacy caused by DDI on transporters for drug absorption and target-tissue distribution, but not associated with toxicity?

Authors:
Ikumi Tamai

Drug Metab Pharmacokinet 2013 ;28(6):451-2

Faculty of Pharmaceutical Sciences, Kanazawa University.

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http://dx.doi.org/10.2133/dmpk.dmpk-13-pf-906DOI Listing
September 2014

Effects of one-time apple juice ingestion on the pharmacokinetics of fexofenadine enantiomers.

Eur J Clin Pharmacol 2014 Sep 7;70(9):1087-95. Epub 2014 Jun 7.

Department of Hospital Pharmacy, Faculty of Medicine, University of the Ryukyus, Okinawa, Japan.

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http://dx.doi.org/10.1007/s00228-014-1705-yDOI Listing
September 2014

Substrate- and dose-dependent drug interactions with grapefruit juice caused by multiple binding sites on OATP2B1.

Pharm Res 2014 Aug 19;31(8):2035-43. Epub 2014 Feb 19.

Faculty of Pharmaceutical Sciences Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kakuma-machi, Kanazawa, 920-1192, Japan.

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http://dx.doi.org/10.1007/s11095-014-1305-7DOI Listing
August 2014

Functional cooperation of SMCTs and URAT1 for renal reabsorption transport of urate.

Drug Metab Pharmacokinet 2013 4;28(2):153-8. Epub 2012 Sep 4.

Department of Membrane Transport and Biopharmaceutics, Faculty of Pharmacy, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan.

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http://dx.doi.org/10.2133/dmpk.dmpk-12-rg-070DOI Listing
July 2014

How does whisky lower serum urate level?

Phytother Res 2014 May 10;28(5):788-90. Epub 2013 Sep 10.

Department of Membrane Transport and Biopharmaceutics, Faculty of Pharmaceutical Sciences, Institute of Medical, Pharmaceutical, and Health Sciences, Kanazawa University, Kakuma-machi, Kanazawa, 920-1192, Japan.

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http://dx.doi.org/10.1002/ptr.5063DOI Listing
May 2014

[Transporter-mediated drug interaction].

Nihon Yakurigaku Zasshi 2014 May;143(5):243-8

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http://dx.doi.org/10.1254/fpj.143.243DOI Listing
May 2014

Transport mechanisms of hepatic uptake and bile excretion in clinical hepatobiliary scintigraphy with 99mTc-N-pyridoxyl-5-methyltryptophan.

Nucl Med Biol 2014 Apr 13;41(4):338-42. Epub 2014 Jan 13.

School of Health Sciences, College of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan.

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http://dx.doi.org/10.1016/j.nucmedbio.2014.01.004DOI Listing
April 2014

Mathematical modeling of the in vitro hepatic disposition of mycophenolic acid and its glucuronide in sandwich-cultured human hepatocytes.

Mol Pharm 2014 Feb 13;11(2):568-79. Epub 2013 Dec 13.

Department of Membrane Transport and Biopharmaceutics, Faculty of Pharmaceutical Sciences, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University , Kakuma-machi, Kanazawa, 920-1192, Japan.

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http://dx.doi.org/10.1021/mp400513kDOI Listing
February 2014

OATP transporter-mediated drug absorption and interaction.

Curr Opin Pharmacol 2013 Dec 20;13(6):859-63. Epub 2013 Sep 20.

Kanazawa University, Institute of Medical, Pharmaceutical and Health Sciences, Faculty of Pharmaceutical Sciences, Kakuma-machi, Kanazawa 920-1192, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.coph.2013.09.001DOI Listing
December 2013

In vivo evidence of organic cation transporter-mediated tracheal accumulation of the anticholinergic agent ipratropium in mice.

J Pharm Sci 2013 Sep 19;102(9):3373-81. Epub 2013 May 19.

Department of Membrane Transport and Biopharmaceutics, Faculty of Pharmaceutical Science, Kanazawa University, Kakuma-machi, Kanazawa 920-1192, Japan.

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http://dx.doi.org/10.1002/jps.23603DOI Listing
September 2013

Major active components in grapefruit, orange, and apple juices responsible for OATP2B1-mediated drug interactions.

J Pharm Sci 2013 Sep 21;102(9):3418-26. Epub 2013 Jun 21.

Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kakuma-machi, Kanazawa 920-1192, Japan.

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http://dx.doi.org/10.1002/jps.23653DOI Listing
September 2013

A role of prostaglandin transporter in regulating PGE₂ release from human bronchial epithelial BEAS-2B cells in response to LPS.

J Endocrinol 2013 Jun 29;217(3):265-74. Epub 2013 Apr 29.

Faculty of Pharmacy, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kakuma-machi, Kanazawa 920-1192, Japan.

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http://dx.doi.org/10.1530/JOE-12-0339DOI Listing
June 2013

Evaluation of hepatic disposition of paroxetine using sandwich-cultured rat and human hepatocytes.

Drug Metab Dispos 2013 Apr 9;41(4):735-43. Epub 2013 Jan 9.

Department of Membrane Transport and Biopharmaceutics, Faculty of Pharmaceutical Sciences, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kakuma-machi, Kanazawa 920-1192, Japan.

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http://dx.doi.org/10.1124/dmd.112.049817DOI Listing
April 2013

Long-lasting inhibitory effect of apple and orange juices, but not grapefruit juice, on OATP2B1-mediated drug absorption.

Drug Metab Dispos 2013 Mar 21;41(3):615-21. Epub 2012 Dec 21.

Faculty of Pharmacy, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kakuma-machi, Kanazawa 920-1192, Japan.

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http://dmd.aspetjournals.org/content/early/2012/12/20/dmd.11
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http://dmd.aspetjournals.org/cgi/doi/10.1124/dmd.112.049635
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http://dx.doi.org/10.1124/dmd.112.049635DOI Listing
March 2013

Functional cooperation of URAT1 (SLC22A12) and URATv1 (SLC2A9) in renal reabsorption of urate.

Nephrol Dial Transplant 2013 Mar 4;28(3):603-11. Epub 2013 Jan 4.

Department of Membrane Transport and Biopharmaceutics, Kanazawa University, Kakuma-machi, Kanazawa , Japan.

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http://dx.doi.org/10.1093/ndt/gfs574DOI Listing
March 2013

Functional pleiotropy of organic anion transporting polypeptide OATP2B1 due to multiple binding sites.

Drug Metab Pharmacokinet 2012 27;27(3):360-4. Epub 2011 Dec 27.

Faculty of Pharmacy, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan.

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http://dx.doi.org/10.2133/dmpk.dmpk-11-sh-080DOI Listing
January 2013

Pharmacological and pathophysiological roles of carnitine/organic cation transporters (OCTNs: SLC22A4, SLC22A5 and Slc22a21).

Authors:
Ikumi Tamai

Biopharm Drug Dispos 2013 Jan 14;34(1):29-44. Epub 2012 Oct 14.

Faculty of Pharmaceutical Sciences, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, 920-1192, Japan.

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http://dx.doi.org/10.1002/bdd.1816DOI Listing
January 2013

Major active components in grapefruit, orange, and apple juices responsible for OATP2B1-mediated drug interactions.

J Pharm Sci 2013 Jan 6;102(1):280-8. Epub 2012 Nov 6.

Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kakuma-machi, Kanazawa 920-1192, Japan.

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http://dx.doi.org/10.1002/jps.23357DOI Listing
January 2013

Enhanced expression of organic anion transporting polypeptides (OATPs) in androgen receptor-positive prostate cancer cells: possible role of OATP1A2 in adaptive cell growth under androgen-depleted conditions.

Biochem Pharmacol 2012 Oct 1;84(8):1070-7. Epub 2012 Aug 1.

Department of Membrane Transport and Biopharmaceutics, Faculty of Pharmaceutical Science, Kanazawa University, Kakuma-machi, Kanazawa, 920-1192, Japan.

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http://dx.doi.org/10.1016/j.bcp.2012.07.026DOI Listing
October 2012

Application of quantitative time-lapse imaging (QTLI) for evaluation of Mrp2-based drug-drug interaction induced by liver metabolites.

Toxicol Appl Pharmacol 2012 Sep 2;263(2):244-50. Epub 2012 Jul 2.

Department of Membrane Transport and Biopharmaceutics, Faculty of Pharmacy, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kakuma-machi, Kanazawa, Ishikawa 920‐1192, Japan.

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http://dx.doi.org/10.1016/j.taap.2012.06.016DOI Listing
September 2012

Active intestinal absorption of fluoroquinolone antibacterial agent ciprofloxacin by organic anion transporting polypeptide, Oatp1a5.

Biopharm Drug Dispos 2012 Sep 30;33(6):332-41. Epub 2012 Aug 30.

Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kakuma-machi, Kanazawa, Japan.

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http://dx.doi.org/10.1002/bdd.1809DOI Listing
September 2012

Genetic polymorphisms of OATP transporters and their impact on intestinal absorption and hepatic disposition of drugs.

Drug Metab Pharmacokinet 2012 20;27(1):106-21. Epub 2011 Dec 20.

Institute of Medical, Pharmaceutical and Health Sciences, Faculty of Pharmacy, Kanazawa University, Kanazawa, Japan.

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http://dx.doi.org/10.2133/dmpk.dmpk-11-rv-099DOI Listing
July 2012

Extra-renal elimination of uric acid via intestinal efflux transporter BCRP/ABCG2.

PLoS One 2012 10;7(2):e30456. Epub 2012 Feb 10.

Department of Membrane Transport and Biopharmaceutics, Faculty of Pharmacy, Institute of Medical, Pharmaceutical, and Health Sciences, Kanazawa University, Kanazawa, Japan.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0030456PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3277506PMC
July 2012

Oral drug delivery utilizing intestinal OATP transporters.

Authors:
Ikumi Tamai

Adv Drug Deliv Rev 2012 May 30;64(6):508-14. Epub 2011 Jul 30.

Department of Membrane Transport and Biopharmaceutics, Faculty of Pharmacy, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Japan.

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http://dx.doi.org/10.1016/j.addr.2011.07.007DOI Listing
May 2012

Carnitine precursor γ-butyrobetaine is a novel substrate of the Na(+)- and Cl(-)-dependent GABA transporter Gat2.

Drug Metab Pharmacokinet 2011 12;26(6):632-6. Epub 2011 Oct 12.

Department of Membrane Transport and Biopharmaceutics, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Japan.

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http://dx.doi.org/10.2133/dmpk.dmpk-11-nt-053DOI Listing
May 2012

Physiologically based pharmacokinetic (PBPK) modeling: it is here to stay!

Biopharm Drug Dispos 2012 Mar 5;33(2):47-50. Epub 2012 Mar 5.

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http://dx.doi.org/10.1002/bdd.1776DOI Listing
March 2012

Effect of back pressure on emulsification of lipid nanodispersions in a high-pressure homogenizer.

Int J Pharm 2012 Jan 17;422(1-2):489-94. Epub 2011 Nov 17.

Research & Development Division, Nippon Shinyaku Co. Ltd., 14 Nishinosho-Monguchi-cho, Kisshoin, Minami-ku, Kyoto 601-8550, Japan.

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http://dx.doi.org/10.1016/j.ijpharm.2011.10.060DOI Listing
January 2012

Synthesis of [¹¹C]uric acid, using [¹¹C]phosgene, as a possible biomarker in PET imaging for diagnosis of gout.

Bioorg Med Chem Lett 2012 Jan 22;22(1):115-9. Epub 2011 Nov 22.

Molecular Probe Dynamics Laboratory, RIKEN Center for Molecular Imaging Science (CMIS), 6-7-3 Minatojima-minamimachi, Chuo-ku, Kobe, Hyogo 650-0047, Japan.

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http://dx.doi.org/10.1016/j.bmcl.2011.11.055DOI Listing
January 2012

Functional characterization of apical transporters expressed in rat proximal tubular cells (PTCs) in primary culture.

Mol Pharm 2011 Dec 28;8(6):2142-50. Epub 2011 Oct 28.

Department of Membrane Transport and Biopharmaceutics, Faculty of Pharmacy, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kakuma-machi, Kanazawa 920-1192 Japan.

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http://dx.doi.org/10.1021/mp200096rDOI Listing
December 2011

Differential effect of grapefruit juice on intestinal absorption of statins due to inhibition of organic anion transporting polypeptide and/or P-glycoprotein.

J Pharm Sci 2011 Sep 24;100(9):3843-53. Epub 2011 Apr 24.

Faculty of Pharmacy, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kakuma-machi, Kanazawa 920-1192, Japan.

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http://dx.doi.org/10.1002/jps.22586DOI Listing
September 2011

Solute carrier transporters as targets for drug delivery and pharmacological intervention for chemotherapy.

J Pharm Sci 2011 Sep 31;100(9):3731-50. Epub 2011 May 31.

Department of Membrane Transport and Biopharmaceutics, Faculty of Pharmacy, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kakuma-machi, Kanazawa 920-1192, Japan.

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http://dx.doi.org/10.1002/jps.22576DOI Listing
September 2011

Oxaliplatin transport mediated by organic cation/carnitine transporters OCTN1 and OCTN2 in overexpressing human embryonic kidney 293 cells and rat dorsal root ganglion neurons.

J Pharmacol Exp Ther 2011 Aug 23;338(2):537-47. Epub 2011 May 23.

Cancer Clinical Pharmacology Research Group, Department of Pharmacology and Clinical Pharmacology, School of Medical Sciences, University of Auckland, 85 Park Rd., Grafton, Private Bag 92019, Auckland 1023, New Zealand.

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http://dx.doi.org/10.1124/jpet.111.181297DOI Listing
August 2011

Quantitative time-lapse imaging-based analysis of drug-drug interaction mediated by hepatobiliary transporter, multidrug resistance-associated protein 2, in sandwich-cultured rat hepatocytes.

Drug Metab Dispos 2011 Jun 17;39(6):984-91. Epub 2011 Mar 17.

Department of Membrane Transport and Biopharmaceutics, Faculty of Pharmacy, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kakuma-machi, Kanazawa, Japan.

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http://dx.doi.org/10.1124/dmd.111.038059DOI Listing
June 2011