Publications by authors named "Ikhwan Sani"

2 Publications

  • Page 1 of 1

Snakehead Consumption Enhances Wound Healing? From Tradition to Modern Clinical Practice: A Prospective Randomized Controlled Trial.

Evid Based Complement Alternat Med 2018 14;2018:3032790. Epub 2018 Nov 14.

Surgery Department, Indra Gandhi Memorial Hospital, Kanbaa Aisa Rani Higun, Malé, Maldives.

Background: Snakehead fish ( is a fresh water fish indigenous to many Asia countries and believed to have medical value. Studies showed that it contains all the essential amino acids and fatty acids able to accelerate wound healing and it has antinociceptive effect. However, little human study has been done to assess the effectiveness of in wound healing. A prospective RCT has been conducted on the effect of spray versus placebo on clean wound to assess its pain control effect and cosmetic outcome.

Methodology: One hundred and two patients (102) underwent clean elective surgery; postoperatively they were randomized into two group. One group received extract spray (n=51) another group received placebo (n=51) on daily basis for 2 weeks. They were followed up on 2, 4, and 6 weeks. Pain control effect was assessed based on Visual Analog Pain Score (VAPS) and cosmetic outcome based on Visual Analog Cosmetic Scale (VACS), Wound Evaluation Scale (WES), and Vancouver Scar Scale (VSS).

Result: The patient treated with spray displayed a better outcome in terms of pain control compared to placebo. During analysis using repeated measure ANOVA, there was significant difference of patient's pain score based on VAPS between spray and placebo (F-stat (df) = 4.80 (2), p-value = 0.010). For cosmetic outcome it showed a better result in spray group for all the 3-scoring system, VACS, (F-stat (df) = 2.68 (2) , p-value <0.001), WES (F-stat (df) = 3.09 (2), p-value = 0.048), and VSS (F-stat (df) = 1.72 (2) , p-value = 0.011).

Conclusion: Our study suggest that application of extract spray on clean wound has shown a significant better pain score result and cosmetic outcome on week 2, week 4, and week 6 comparatively with placebo.
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http://dx.doi.org/10.1155/2018/3032790DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6261081PMC
November 2018

Prospective diagnostic study on the use of narrow-band imaging on suspicious lesions during colonoscopy examination.

Asian J Endosc Surg 2018 Nov 8;11(4):318-324. Epub 2018 Feb 8.

Department of Surgery, School of Medical Sciences, Universiti Sains Malaysia, Kota Bharu, Kelantan, Malaysia.

Introduction: Colonoscopy is the gold standard to detect colorectal neoplasm. Narrow-band imaging (NBI) has a good diagnostic accuracy to differentiate between neoplastic and non-neoplastic colorectal lesions. This study explores the diagnostic validity of NBI colonoscopy as well as its associated factors related to neoplastic and non-neoplastic colorectal lesions.

Methods: This study enrolled 100 patients in a single-center tertiary teaching hospital. Patients presented for screening colonoscopy, and those with suspicious colorectal lesions were included in this study. During colonoscopy, the most suspicious lesion in each patient was analyzed using the NBI system based on Sano's classification. Each lesion was biopsied for histopathological analysis, the gold standard. Endoscopic images were captured electronically. The sensitivity, specificity, and diagnostic accuracy of NBI colonoscopy were assessed. Other associated factors related to neoplastic and non-neoplastic lesions were analyzed accordingly.

Results: The sensitivity and specificity of the NBI were 88.2% and 71.9%, respectively. The area under the receiver-operator curve was 0.801, indicating that NBI has a good ability to differentiate between disease and non-disease. There are significant associations between histopathological examination outcomes and both presenting symptoms, especially weight loss, and lesion site, even after other variables were controlled (P < 0.05).

Conclusion: The NBI system in colonoscopy was capable of distinguishing neoplastic from non-neoplastic colorectal lesions. It indicates an acceptable level of agreement with histopathology, the gold standard. However, the role of NBI in screening and surveillance in Malaysia still needs further evaluation and exploration.
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http://dx.doi.org/10.1111/ases.12463DOI Listing
November 2018
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