Publications by authors named "Ihsan Baglı"

17 Publications

  • Page 1 of 1

A prospective cohort study of shock index as a reliable marker to predict the patient's need for blood transfusion due to postpartum hemorrhage.

Pak J Med Sci 2021 May-Jun;37(3):863-868

Ihsan Bagli, Department of Obstetrics and Gynecology, Health Sciences University, Gazi Yasargil Training and Research Hospital, Diyarbakir, Turkey.

Objective: This study was aimed to compare the shock index (SI) values between patients who required blood transfusion due to postpartum hemorrhage (PPH) and patients who received no blood transfusion.

Methods: We conducted this cross-sectional study at a tertiary center between January 2019 and June 2019. A total of 2534 patients who underwent vaginal delivery were included in this study. We measured SI values upon admission, 30 minutes, 1-hour, and 2-hours after delivery. We identified women who required blood transfusion as the study group. Control patients who delivered in the same period and received no blood transfusion were identified in the medical record system and randomly selected. Age, parity, BMI, and SI values at each one prepartum and three postpartum periods of the groups were analyzed.

Results: A total of 2534 patients were included in the study. A varying amount of blood transfusion was performed in 54 patients (2.13%). When we compared with patients who did not receive blood transfusion after delivery, patients who received any amount of blood transfusion after vaginal delivery had significantly higher SI values 30 minutes after delivery (0.99±0.20, and 085±0.11, p=0.0001), at 1-hour (1.00±0.18, and 0.85±0.11, p=0.0001), and 2-hours (1.09±0.16, and 0.87±0.11, p=0.0001).

Conclusion: SI value could be a reliable and consistent marker to predict the requirement for any amount of blood transfusion due to PPH.
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http://dx.doi.org/10.12669/pjms.37.3.3444DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8155416PMC
June 2021

Evaluation of the effect of Birth Preparation Program on birth satisfaction with "Salmon's Item List" scale.

Ginekol Pol 2021 Mar 23. Epub 2021 Mar 23.

Department of Obstetrics and Gynecology, Gazi Yaşargil Training and Research Hospital, Diyarbakır, Turkey.

Objectives: The aim of this study is to investigate the effects of a birth preparation program on birth satisfaction.

Material And Methods: This cross-sectional study was conducted with patients who applied to our hospital between January 2018 and January 2019. A total of 164 pregnant women (Study Group) who applied for the birth preparation program and completed all training in our hospital and 152 pregnant women who did not apply for the birth preparation program and who did not know about such training (Control Group) were included in the study. Demographical data and obstetric parameters of the groups were recorded. All patients were evaluated with the Visual Analog Scale and Salmon's Item List scale 48 hours after the delivery. The scores of both groups were compared.

Results: There were no significant differences between the groups in terms of age, gravida, parity, gestational week of birth, the birth weight of infants, and 5th-minute APGAR scores. It was found that the Visual Analog Scale scores of the Control Group were significantly higher than in the Study Group. The Salmon's Item List scores of the Study Group were significantly higher than those of the patients in the Control Group (< 0.01).

Conclusions: The birth preparation program increases satisfaction during labor and decreases the traumas that may occur in the following births and increase comfort in the postpartum period. For this reason, such programs must be applied commonly to ensure that women can face both the birth and postpartum processes comfortably.
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http://dx.doi.org/10.5603/GP.a2021.0010DOI Listing
March 2021

PALM-COEIN classification system of FIGO vs the classic terminology in patients with abnormal uterine bleeding.

Ginekol Pol 2021 Mar 23. Epub 2021 Mar 23.

Cukurova University, Adana, Turkey.

Objectives: To evaluate the FIGO's novel classification system versus the classic terminology in patients with abnormal uterine bleeding.

Material And Methods: A retrospective study was carried out between August 2015 and September 2019 in the Health Sciences University Gazi Yaşargil Training and Research Hospital. The pathology reports of the patients were classified according to the PALM-COEIN method and were compared with classical terminology. The operated patients with fibroids reported in the pathology results were classified as subgroups of fibroids.

Results: Evaluation was made of a total of 515 women with abnormal uterine bleeding. According to the classical terminology, 137 (26.6%) patients were defined with hypermenorrhea, 74 (14.4%) with menorrhagia, 57 (11.1%) with metrorrhagia, and 246 (47.8%) with menometrorrhagia. In the PALM-COEIN classification system, polyps were determined in 84 (16.3%) cases, adenomyosis in 228 [diffuse adenomyosis: 196 (38.1%), local adenomyosis: 32 (6.2%)], leiomyoma in 386 [submu-cous: 161 (31.1%), other types: 225 (43.9%)], and malignancy and hyperplasia in 47 (9.1%).

Conclusions: The classical terminology for abnormal uterine bleeding is insufficient in terms of etiological pathologies in non-pregnant women of reproductive age. The widespread use of this novel system for the abnormal uterine bleeding classification will provide a more useful communication between physicians and researchers.
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http://dx.doi.org/10.5603/GP.a2021.0011DOI Listing
March 2021

Is suction curettage an effective treatment alternative for cesarean scar pregnancies?

Eur J Obstet Gynecol Reprod Biol 2021 Mar 6;258:193-197. Epub 2021 Jan 6.

University of Health Sciences Diyarbakir Gazi Yasargil Research and Training Hospital, Department of Obstetrics and Gynecology, Diyarbakır, Turkey.

Objectives: The study aims to evaluate the success rate of suction curettage (SC) as a first line treatment with or without use of foley balloon tamponade for cesarean scar pregnancy (CSP) and to determine the risk factors for failure of treatment.

Study Design: The study was retrospective and included 36 CSP cases who underwent SC for treatment. Presence of pain with active bleeding and > 10 weeks of gestation were taken as the exclusion criterion. The procedure was performed under sonographic guidance. After the procedure, in patients who had a hemorrhage foley catheter was inserted into the uterine cavity. SC failure was defined as a requirement of secondary intervention. CSP types, myometrial thickness in the scar area, fetal cardiac activity, initial Beta human chorionic gonadotropin levels (β-HCG), history of vaginal delivery were compared between successful and failed groups.

Result: Of 36 patients, 31 had favorable results with SC ± foley balloon tamponade. Success rate was found to be 86 % (31/36) as the first line therapy. Foley catheter was applied for 23 patients, among them, four were in the failed group and 19 were in the favorable group. In the failed group, two patients had emergent laparotomy, two had repeat SC the day after the initial treatment and one patient was treated with systemic MTX. Fetal cardiac activity and presence of embryonic pole were not different between the groups (p = 1.000, p = 0.829 respectively). Myometrial thickness in the failed group was less than the successful group, this difference was significant (p = 0.033). CSP types, initial β-HCG levels and history of vaginal delivery were not different between the groups (p = 0.149, p = 0.372 and p = 0.404 respectively).

Conclusion: SC may be considered as a first line therapy for CSPs, and and in patients complicated with hemorrhage foley balloon tamponade can be used easily. Thinner myometrium at previous cesarean scar can be considered as a risk factor for failure of SC in patients with CSP.
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http://dx.doi.org/10.1016/j.ejogrb.2021.01.002DOI Listing
March 2021

The effect of vaginal disinfection on reducing post-caesarean endometritis: A prospective, randomised controlled trial.

J Gynecol Obstet Hum Reprod 2021 Mar 10;50(3):101981. Epub 2020 Nov 10.

University of Health Sciences Diyarbakir Gazi Yasargil Research and Training Hospital, Department of Obstetrics and Gynecology, Diyarbakır, Turkey.

Purpose: We aimed to evaluate the efficacy of vaginal disinfection using 10 % povidone-iodine on rates of endometritis from post-caesarean infectious diseases before elective caesarean section (CS).

Methods: A total of 270 pregnant women who chose to undergo elective CS were recruited for this prospective randomised controlled study. The experimental group comprised 130 patients who had preoperatively undergone vaginal disinfection with 10 % povidone-iodine for 30 s. The control group consisted of 140 patients who had not undergone any vaginal implication before CS. The primary outcome measure was the rate of postpartum endometritis for each group. Intraoperatively, all patients who had closed uterine cervical canals underwent a digital opening of the internal and external cervical canal to equalise the groups. All of the participants were checked for endometritis one week after CS at the hospital. Additionally, for the week before and after surgery, C-reactive protein (CRP) and white blood cell (WBC) values were assessed for both groups. Ethics committee approval number: 339. Statistical analysis was performed using R version 3.5.1 (R statistical Software, Institute for Statistics and Mathematics, Vienna, Austria).

Results: The groups were balanced in terms of the patients' demographic characteristics. There were no significant differences between the two groups according to endometritis rates: 4.6 % in the study group versus 6.4 % in the control group (p > 0.05). The CRP and WBC values before CS were similar in both groups. In the study group, the CRPand WBC values after CS were lower, whereas they were higher in the control group after CS; these differences were significant (p = 0.01 for CRP and p = 0.001 for WBC).

Conclusion: Vaginal disinfection with povidone-iodine solution 10 % before elective CS does not significantly reduce post-caesarean endometritis rates; however, it does significantly reduce inflammatory markers such as CRP and WBC.
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http://dx.doi.org/10.1016/j.jogoh.2020.101981DOI Listing
March 2021

Explanatory variables and nomogram of a clinical prediction model to estimate the risk of caesarean section after term induction.

J Obstet Gynaecol 2021 Apr 15;41(3):367-373. Epub 2020 Oct 15.

Department of Neonatology, Health Sciences University Gaziyaşargil Education and Research Hospital, Diyarbakır, Turkey.

The aims of this study were to identify the explanatory variables associated with failure of induction of labour (IOL) and to designate nomograms that predict probability. This retrospective study included 1328 singleton term pregnant women (37-42 weeks). The penalised maximum likelihood estimation (PMLE) method was used instead of traditional logistic regression. Of the 25,678 deliveries that occurred during the study period, 1328 (5.1%) women underwent term delivery. Of those, 1125 (84.7%) had successful vaginal deliveries and 203 (15.3%) had failed vaginal deliveries following use of a dinoprostone slow-release vaginal insert. Explanatory variables were discovered that were associated with delivery failure in term pregnancy undergoing induction of labour with an unfavourable cervix, and a nomogram that predicted probability was developed.IMPACT STATEMENT The caesarean rate has continued to climb worldwide over the past decade. Most caesarean sections are performed because of suspected foetal distress or failure to progress. In absolute numbers, most caesarean deliveries are performed in women with a term pregnancy with a foetus in cephalic presentation. Despite these numbers, predicting the mode of delivery by which these women will deliver remains a challenge. Five explanatory variables were strongly associated with failure of dinoprostone delivery of term pregnancies: nulliparity, induction time, premature rupture of membranes, Bishop score and foetal gender The developed nomograms enable fast and easy implementation in clinical practice. After external validation and proof of generalisability, the present model could be used in obstetric clinical management.
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http://dx.doi.org/10.1080/01443615.2020.1798902DOI Listing
April 2021

Comparison of novel two-port and conventional multiport laparoscopic surgery approaches for benign adnexal masses: The Bagli method.

J Obstet Gynaecol Res 2020 Nov 19;46(11):2272-2279. Epub 2020 Aug 19.

Department of Obstetrics and Gynecology, University of Health Sciences, Diyarbakir Gazi Yasargil Research and Training Hospital, Diyarbakır, Turkey.

Aim: This study primarily aims to describe the safety and efficacy of a novel two-port (5 and 10-mm) laparoscopic surgery (TPLS) approach for benign adnexal masses compared with conventional multiport laparoscopic surgery (CMLS) in excisional procedures such as salpingectomy and oophorectomy.

Methods: This is a retrospective case-control study. Forty-four patients were divided into two groups: two-port (5 mm and 10 mm) laparoscopic surgery group (n: 22) and conventional multiport (three/four port) laparoscopic surgery group (n: 22), with similar indications. All procedures, except ovarian detorsions, included salpingectomy, oophorectomy or salpingo-ophorectomy. The groups were evaluated using their demographic, clinical, intraoperative and postoperative data, and survey questions that were asked were used for analyzing cosmetic satisfaction, surgical satisfaction and preference rates of the TPLS.

Results: There were no significant differences between the groups on demographic features. All patients were discharged within 24 h after both the procedures without any major (organ injury) or minor complication. Surgical satisfaction range was 8.82 (±1.01) in TPLS group and 7.27 (±1.6) in the CMLS group, and differences were significant (P = 0.002). Satisfaction with cosmesis was 95% in the TPLS group and 77% in the CMLS group, and this difference was not significant (P = 0.11). The preferences rate of TPLS was 68% among the 44 women.

Conclusion: Novel TPLS is feasible and safe in expert hands. In addition, it provides more surgical satisfaction to patients. However, there were not significant differences in long-term cosmesis results between the TPLS and CMLS groups.
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http://dx.doi.org/10.1111/jog.14420DOI Listing
November 2020

Increased oxidative stress is associated with thiol/disulphide homeostasis in clomiphene citrate resistant polycystic ovary syndrome.

J Obstet Gynaecol 2021 Apr 25;41(3):467-470. Epub 2020 Jun 25.

Department of Gynecology and Obstetrics, Gazi Yasargil Training and Research Hospital, Health Sciences University, Diyarbakır, Turkey.

The purpose of this study was to evaluate the relation CC resistant PCOS and the thiol/disulphide homeostasis, used as a marker of OS, by measuring that exchange using a novel technique. Sixty women patients admitted to the infertility clinic were evaluated. The patients were divided into two groups. Group 1 comprised 30 infertile PCOS patients with CC resistance; Group 2 was the control group comprising 30 infertile PCOS patients with CC sensitivity. Serum total thiol ( = .024), native thiol ( = .0052), disulphide ( = .003), index 1 ( = .001), index 2 ( = .001) and index 3 ( = .001), HOMA-IR ( < .001) and free testosterone (  .001) were statistically significant. The independent variables BMI and age effects were adjusted according to the logistic regression method with groups. Significant differences were observed between the two groups in the levels of native thiol (* = .0042), total thiol (* = .024), disulphide (* = .0003), index 1 (* = .0001) index 2 (*= .0001), index 3 (* = .0001), HOMA-IR (* = .0044), insulin (*= .032) and free testosterone (* = .0001) values. The thiol/disulphide homeostasis viewed in favour of OS. Like a reflection of OS in the follicular endocrine microenvironment may be linked with increased thiol/disulphide homeostasis, free testosterone, insulin and HOMA-IR levels.Impact statement In previous studies, thiol/disulphide homeostasis was compared between PCOS and control groups. In this study, serum thiol/disulphide homeostasis was measured in infertile PCOS patients resistant to CC for the first time. Disulphide concentrations were significantly higher in patients with CC resistant patients thanthe control group. This shows us that more OS occurs in the CC-resistant group. Thiol/disulphide homeostasis will be a guide for PCOS management in patients with CC-resistant PCOS.
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http://dx.doi.org/10.1080/01443615.2020.1786033DOI Listing
April 2021

Pregnancy outcomes after laparoscopic pectopexy surgery: A case series.

J Obstet Gynaecol Res 2020 Aug 1;46(8):1364-1369. Epub 2020 Jun 1.

Department of Obstetrics and Gynecology, University of Health Sciences Diyarbakir Gazi Yasargil Researchand Training Hospital, Diyarbakir, Turkey.

Aim: We aimed to present the outcomes of five pregnant women who had laparoscopic pectopexy in their past.

Methods: In this retrospective cohort study, we reviewed all female patients who underwent modified laparoscopic pectopexy between 2016 and 2018 at our hospital. Polypropylene monofilament mesh was used for the pectopexy procedure in 36 cases of women suffering from apical pelvic organ prolapse (POP). Five women were pregnant at different dates after the surgery; we included them in the study (n = 5). We collected data including age, gravidity, parity, magnetic resonance image, sonographic image, POP - Quantification scores, neonatal results from the hospital database.

Results: After uneventful examinations during pregnancy, four women delivered via caesarean section; one of them got pregnant again and delivered successfully. We did not see relapse in apical prolapse or other compartments 3, 6 and 12 months after delivery. All women gave high satisfaction scores regarding POP at 12 months after delivery.

Conclusion: Laparoscopic pectopexy is an effective and alternative procedure for women with POP and a good option for preserving fertility. We found that pregnancy did not adversely affect the short-term success of laparoscopic pectopexy, and vice versa.
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http://dx.doi.org/10.1111/jog.14337DOI Listing
August 2020

Laparoscopic Pectopexy and Paravaginal Repair after Failed Recurrent Pelvic Organ Prolapse Surgery.

Gynecol Minim Invasive Ther 2020 Jan-Mar;9(1):42-44. Epub 2020 Jan 23.

Department of Obstetrics and Gynecology, Memorial Dicle Hospital, Diyarbakır, Turkey.

Laparoscopic pectopexy has been described recently for pelvic organ prolapse (POP) and it could be an alternative surgery to sacrohysteropexy. A 36-year-old parity 3 women was operated cause of POP, and on her history, she had performed one sacrospinous ligament fixation with colporrhaphy anterior and one abdominal sacrohysteropexy because of POP. After 6-month follow-up, anatomic and functional cures were provided. Laparoscopic pectopexy could be an alternative procedure for recurrent POP surgery with promising results.
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http://dx.doi.org/10.4103/GMIT.GMIT_101_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7008650PMC
January 2020

Maternal serum thiol/disulfide homeostasis in pregnancies complicated by fetal hypoxia.

J Obstet Gynaecol 2020 Nov 12;40(8):1085-1089. Epub 2019 Dec 12.

Department of Gynecology and Obstetrics, İstanbul Science University, Florance Nightingale Hospital, İstanbul, Turkey.

We aimed to evaluate maternal serum thiol/disulphide homeostasis in pregnancies complicated by fetal distress (FD). A total of 100 patients beyond the 34th week of pregnancy were included in this study, and they were divided into two groups. The study group included 50 patients who had been diagnosed with FD; the control group was composed of 50 patients who had shown no signs of FD and who had undergone an elective (previous) caesarean section (CS). The native thiol, total thiol and native thiol/total thiol (%) concentrations were lower in Group 1 patients than Group 2 patients ( < .001). The disulphide, disulphide/native thiol (%) and disulphide/total thiol (%) concentrations were higher in Group 1 patients than Group 2 patients ( < .001). This study suggests that maternal thiol/disulphide homeostasis is impaired in pregnancies complicated by FD.IMPACT STATEMENT Oxidative stress (OS) has previously been investigated in FD. This study reports for the first time a new novel and automatic measurement method. This study shows that the thiol balance shifts in the direction of disulphide in the cases of FD. Thiol balance can be used for the timely diagnosis of FD.
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http://dx.doi.org/10.1080/01443615.2019.1680616DOI Listing
November 2020

Evaluation of catalase, myeloperoxidase and ferroxidase values in pregnant women with hyperemesis gravidarum.

Ginekol Pol 2019 ;90(11):651-655

Department of Internal Medicine, Health Sciences University, Gazi Yasargil Training and Research Hospital, Diyarbakir, Turkey.

Objectives: To investigate maternal serum catalase, myeloperoxidase and ferroxidase levels in pregnant women withHyperemesis Gravidarum and to compare the results with healthy pregnancies.

Material And Methods: In this study, 60 female patients admitted to the Health Sciences University, Gazi Yaşargil Trainingand Research Hospital, Gynecology and Obstetrics Department were evaluated. The patients were divided into two groups:Group 1 included 30 pregnant women with hyperemesis gravidarum; Group 2 included 30 healthy pregnant women.Pregnancies over 14 weeks were excluded from the study.

Results: The laboratory and laboratory characteristics of both groups are shown in Table 1. No significant differences werefound between the groups in terms of the maternal age, gestational age, gravidity, parity, fasting glucose level, and BMI.The maternal blood CAT levels were significantly higher in the HG group (219.6 ± 111.3 kU/L) when compared to the controlgroup (71.5 ± 52.5 kU/L) (p < 0.001). The maternal blood MPO levels were lower in the control group (121.5 ± 36.3 U/L)than in the study group (90.9 ± 56.4 U/L) (p = 0.016). However, the ferroxidase levels were similar between the twogroups. The independent variables BMI, age, parity, gravidity and gestational week effects were adjusted according to thelogistic regression method with groups. Significant differences were observed between the two groups in the levels ofCAT (0.001), MPO (0.005) values.

Conclusions: This study suggests that antioxidants in response to oxidative stress gave different reactions with differentmechanisms; Also, we believe that insufficient food intake suppresses the immune system and this has an important roleon antioxidants.
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http://dx.doi.org/10.5603/GP.2019.0110DOI Listing
June 2020

Uterine torsion at term pregnancy associated with a previous pelvic organ prolapse (POP) surgery.

J Obstet Gynaecol 2020 May 8;40(4):569-570. Epub 2019 Aug 8.

Department of Obstetrics and Gynecology, University of Health Sciences, Diyarbakir Gazi Yasargil Research and Training Hospital, Diyarbakır, Turkey.

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http://dx.doi.org/10.1080/01443615.2019.1615042DOI Listing
May 2020

An investigation of the effect of placental growth factor on intrapartum fetal compromise prediction in terminduced high risk pregnancies.

Ginekol Pol 2018 ;89(12):700-704

Department of Obstetrics and Gynecology, Health Sciences University Diyarbakır Gazi Yaşargil Education and Research Hospital, Diyarbakır, Turkey.

Objectives: To date, there is no available test to predict the risk of intrapartum fetal compromise (IFC) during labor, either starting spontaneously or induced due to obstetrics indications. The aim of this study was to examine the effectiveness of placental growth factor (PIGF) in identifying cases that develop intrapartum fetal compromise (IFC) in term high-risk pregnancies induced for labor.

Material And Methods: This prospective cross-sectional study was conducted on 40 IFC+ cases and 40 IFC- cases with high-risk term pregnancy and labor induction started in the Health Sciences University Gazi Yaşargil Training and Research Hospital, between January 2018 and April 2018. Comparisons were made between the groups in respect of placental growth factor (PIGF) levels, and obstetric and neonatal outcomes.

Results: The PIGF level was found to be statistically significantly lower in the IFC+ cases compared to the IFC- cases. For a PIGF cutoff value of 32 pg/mL for the prediction of IFC+ cases, sensitivity was 74.4%, specificity 73.2%, NPV 75% and PPV 72.5%, with a statistically significant difference determined between the groups. The IFC+ development risk increased 7.91-fold in patients with PIGF ≤ 32 pg/mL.

Conclusions: The PIGF levels in cases of IFC+ high risk pregnancies were found to be statistically significantly lower than those of IFC- cases. However, further, large-scale randomized controlled research is necessary to demonstrate this relationship better.
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http://dx.doi.org/10.5603/GP.a2018.0118DOI Listing
August 2019

A single centre's experience of caesarean scar pregnancy and proposal of a management algorithm.

J Obstet Gynaecol 2019 Feb 29;39(2):259-264. Epub 2018 Oct 29.

a Department of Obstetrics and Gynecology , University of Health Sciences Gazi Yasargil Research and Training Hospital , Diyarbakir , Turkey.

The management of a caesarean scar pregnancy ranges from conservative medical therapy to surgical treatment. The aim of this study is to present our experience of caesarean scar ectopic pregnancies treated with different modalities and to develop a management algorithm. This retrospective clinical analysis included 21 caesarean scar pregnancies. The clinical data, ultrasonographic characteristics, b-human chorionic gonadotropin concentrations, the treatment options and complications were noted. One patient was managed expectantly, six patients were treated with D and C, seven patients were treated with systemic methotrexate, eight patients underwent a caesarean scar pregnancy removal with a laparoscopy, three patients were treated with a hysteroscopy. Three patients who recieved a methotrexate required additional treatment methods including a laparoscopy, hysteroscopy and D and C. Surgery was successful in all cases. An intra-abdominal haemorrhage from the vessels in the scar area occured in the patient managed expectantly, and a laparatomy and removal was performed. A systemic methotrexate, dilatation and curettage, hysteroscopic resection and laparoscopic resection are feasible methods for scar pregnancy treatment depending on the gestational age, β-hCG level, the type of scar pregnancy and the clinical status of the patient. IMPACT STATEMENT What is already known on this subject? CSP has increased gradually parallel to the increased rates of CS worldwide. There is no treatment consensus on that rare entity. What do the results of this study add? We aimed to present our cases and to discuss a proposal algorithm with further studies. What are the implications of these findings for clinical practice and/or further research? Our cases and proposal algorithm could help to determine the treatment options for CSP.
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http://dx.doi.org/10.1080/01443615.2018.1499714DOI Listing
February 2019

Modified laparoscopic pectopexy: short-term follow-up and its effects on sexual function and quality of life.

Int Urogynecol J 2018 08 2;29(8):1155-1160. Epub 2018 Mar 2.

Obstetrics and Gynecology Department, Zeynep Kamil Research and Training Hospital, Istanbul, Turkey.

Introduction And Hypothesis: This study examined the early outcomes of laparoscopic (LS) pectopexy and evaluated its effects on female sexual function and quality of life (QoL).

Methods: Twenty-two patients with apical prolapse who underwent LS pectopexy were included. Outcomes of the procedure were noted; the Female Sexual Function (FSFI) and Prolapse Quality of Life (P-QOL) questionnaires were completed preoperatively and 6 months postoperatively.

Results: There was no evidence of recurrent prolapse or constipation; the percentages of exacerbation of cystocele, rectocele, de novo stress urinary incontinence (SUI), and de novo urgency (UUI) were 4.5%, 9.0%, 4.5%, and 4.5%, respectively (mean follow-up 10.41 months). FSFI and P-QOL scores improved significantly (p < 0.05) postoperatively.

Conclusions: LS pectopexy shows promising results for pelvic organ prolapse (POP) surgery with comparable outcomes. It also improved the FSFI and P-QOL scores in POP patients.
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http://dx.doi.org/10.1007/s00192-018-3565-yDOI Listing
August 2018

Interleukin-6 levels in relation with hormonal and metabolic profile in patients with polycystic ovary syndrome.

Gynecol Endocrinol 2014 Jun 14;30(6):423-7. Epub 2014 Mar 14.

Department of Gynecology and Obstetrics, Faculty of Medicine, Muğla Sıtkı Koçman University , Muğla , Turkey .

Objective: The aim of this study was to evaluate serum concentrations of interleukin-6 (IL-6) in relation with hormonal and metabolic profile in patients with and without polycystic ovary syndrome (PCOS).

Methods: A total of 40 women with PCOS and 40 age-matched controls were eligible for the study. Hirsutism scores, hormonal and metabolic profile as well as IL-6 levels were evaluated in each subject.

Results: Women with PCOS exhibited higher body mass index (BMI) and serum concentrations of IL-6 levels than controls (p < 0.05); however, levels of IL-6 were not significantly increased when compared with BMI-matched controls (p > 0.05). IL-6 levels were significantly correlated positively with BMI and triglyceride levels; however, negatively correlated with high-density lipoprotein levels.

Conclusion: The data of this study suggested that serum IL-6 levels were found to be higher in women with PCOS as compared to controls; however, IL-6 levels might be dependent on nutritional status but not on PCOS per se. Raised serum IL-6 levels may be related to BMI and serum lipid levels and may be a predictor for cardiometabolic risks.
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http://dx.doi.org/10.3109/09513590.2014.895981DOI Listing
June 2014