Ihn Sik Seong

Ihn Sik Seong

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Ihn Sik Seong

Ihn Sik Seong

Publications by authors named "Ihn Sik Seong"

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25Publications

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Full sequence of mutant huntingtin 3'-untranslated region and modulation of its gene regulatory activity by endogenous microRNA.

J Hum Genet 2019 Oct 11;64(10):995-1004. Epub 2019 Jul 11.

Molecular Neurogenetics Unit, Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, 02114, USA.

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http://dx.doi.org/10.1038/s10038-019-0639-8DOI Listing
October 2019

Novel DNA Aptamers that Bind to Mutant Huntingtin and Modify Its Activity.

Mol Ther Nucleic Acids 2018 Jun 16;11:416-428. Epub 2018 Mar 16.

Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA 02114, USA; Department of Neurology, Harvard Medical School, Boston, MA 02114, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S21622531183003
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http://dx.doi.org/10.1016/j.omtn.2018.03.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5992459PMC
June 2018

Post-Translational Modifications (PTMs), Identified on Endogenous Huntingtin, Cluster within Proteolytic Domains between HEAT Repeats.

J Proteome Res 2017 08 3;16(8):2692-2708. Epub 2017 Jul 3.

Division of Neurobiology, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine , 600 North Wolfe Street, CMSC 8-121, Baltimore, Maryland 21287, United States.

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http://dx.doi.org/10.1021/acs.jproteome.6b00991DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5560079PMC
August 2017

HD CAG-correlated gene expression changes support a simple dominant gain of function.

Hum Mol Genet 2011 Jul 2;20(14):2846-60. Epub 2011 May 2.

Center for Human Genetic Research, Massachusetts General Hospital, 185 Cambridge Street, Boston, MA 02114, USA.

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http://dx.doi.org/10.1093/hmg/ddr195DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3118763PMC
July 2011

Striatal neurons expressing full-length mutant huntingtin exhibit decreased N-cadherin and altered neuritogenesis.

Hum Mol Genet 2011 Jun 29;20(12):2344-55. Epub 2011 Mar 29.

Molecular Neurogenetics Unit, Center for Human Genetic Research, Center for Human Genetic Research, Massachusetts General Hospital, 185 Cambridge Street, Boston, MA 02114, USA.

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http://dx.doi.org/10.1093/hmg/ddr127DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3098733PMC
June 2011

Crystal structure of Bacillus subtilis CodW, a noncanonical HslV-like peptidase with an impaired catalytic apparatus.

Proteins 2008 May;71(2):1020-6

Department of Life Science, Cell Dynamics Research Center, Gwangju Institute of Science and Technology, Gwangju 500-712, Korea.

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http://dx.doi.org/10.1002/prot.21758DOI Listing
May 2008

Unbiased gene expression analysis implicates the huntingtin polyglutamine tract in extra-mitochondrial energy metabolism.

PLoS Genet 2007 Aug 27;3(8):e135. Epub 2007 Jun 27.

Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.0030135DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1950164PMC
August 2007

HD CAG repeat implicates a dominant property of huntingtin in mitochondrial energy metabolism.

Hum Mol Genet 2005 Oct 22;14(19):2871-80. Epub 2005 Aug 22.

Molecular Neurogenetics UNIT, Center for Human Genetic Research, Massachusetts General Hospital, Richard B. Simches Research Center, Boston, MA 02114, USA.

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http://dx.doi.org/10.1093/hmg/ddi319DOI Listing
October 2005

Role of the GYVG pore motif of HslU ATPase in protein unfolding and translocation for degradation by HslV peptidase.

J Biol Chem 2005 Jun 22;280(24):22892-8. Epub 2005 Apr 22.

NRL of Protein Biochemistry, School of Biological Sciences, Seoul National University, Korea.

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http://dx.doi.org/10.1074/jbc.M500035200DOI Listing
June 2005

Enhanced Akt signaling is an early pro-survival response that reflects N-methyl-D-aspartate receptor activation in Huntington's disease knock-in striatal cells.

J Biol Chem 2003 Dec 1;278(50):50514-22. Epub 2003 Oct 1.

Molecular Neurogenetics Unit, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA.

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http://dx.doi.org/10.1074/jbc.M309348200DOI Listing
December 2003

Specific progressive cAMP reduction implicates energy deficit in presymptomatic Huntington's disease knock-in mice.

Hum Mol Genet 2003 Mar;12(5):497-508

Molecular Neurogenetics Unit, Massachusetts General Hospital, Building 149, 13th St, Charlestown, MA 02129, USA.

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http://dx.doi.org/10.1093/hmg/ddg046DOI Listing
March 2003

The C-terminal tails of HslU ATPase act as a molecular switch for activation of HslV peptidase.

J Biol Chem 2002 Jul 14;277(29):25976-82. Epub 2002 May 14.

National Research Laboratory of Protein Biochemistry, School of Biological Sciences, Seoul National University, Seoul 151-742, Korea.

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http://dx.doi.org/10.1074/jbc.M202793200DOI Listing
July 2002