Publications by authors named "Igor Jurisica"

100Publications

BioPAX-Parser: parsing and enrichment analysis of BioPAX pathways.

Bioinformatics 2020 Aug;36(15):4377-4378

Data Analytics Research Center, Magna Graecia University of Catanzaro, Catanzaro, Italy.

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http://dx.doi.org/10.1093/bioinformatics/btaa529DOI Listing
August 2020

Physiological Tau Interactome in Brain and Its Link to Tauopathies.

J Proteome Res 2020 06 7;19(6):2429-2442. Epub 2020 May 7.

Institute of Neuroimmunology, Slovak Academy of Sciences, Dubravska cesta 9, Bratislava 84510, Slovakia.

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http://dx.doi.org/10.1021/acs.jproteome.0c00137DOI Listing
June 2020

GSOAP: a tool for visualization of gene set over-representation analysis.

Bioinformatics 2020 05;36(9):2923-2925

Krembil Research Institute, UHN, 60 Leonard Avenue, Toronto, ON M5T 0S8, Canada.

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http://dx.doi.org/10.1093/bioinformatics/btaa001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7203738PMC
May 2020

Informed Use of Protein-Protein Interaction Data: A Focus on the Integrated Interactions Database (IID).

Methods Mol Biol 2020 ;2074:125-134

Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.

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http://link.springer.com/10.1007/978-1-4939-9873-9_10
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http://dx.doi.org/10.1007/978-1-4939-9873-9_10DOI Listing
January 2020

Why imaging data alone is not enough: AI-based integration of imaging, omics, and clinical data.

Eur J Nucl Med Mol Imaging 2019 Dec 15;46(13):2722-2730. Epub 2019 Jun 15.

Departments of Medical Biophysics and Computer Science, University of Toronto, Toronto, Canada.

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http://dx.doi.org/10.1007/s00259-019-04382-9DOI Listing
December 2019

Urine Angiotensin II Signature Proteins as Markers of Fibrosis in Kidney Transplant Recipients.

Transplantation 2019 06;103(6):e146-e158

Toronto General Hospital Research Institute, Advanced Diagnostics Division, University Health Network, Toronto, ON, Canada.

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http://dx.doi.org/10.1097/TP.0000000000002676DOI Listing
June 2019

The complex landscape of microRNAs in articular cartilage: biology, pathology, and therapeutic targets.

JCI Insight 2018 09 6;3(17). Epub 2018 Sep 6.

Arthritis Program, Toronto Western Hospital, University Health Network, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1172/jci.insight.121630DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6171796PMC
September 2018

Citrobacter rodentium alters the mouse colonic miRNome.

Genes Immun 2019 03 1;20(3):207-213. Epub 2018 May 1.

Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto,, ON, Canada.

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http://www.nature.com/articles/s41435-018-0026-z
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http://dx.doi.org/10.1038/s41435-018-0026-zDOI Listing
March 2019

In silico cancer research towards 3R.

BMC Cancer 2018 04 12;18(1):408. Epub 2018 Apr 12.

Holzinger Group, Institute for Medical Informatics, Statistics and Documentation, Medical University Graz, Graz, Austria.

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http://dx.doi.org/10.1186/s12885-018-4302-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5897933PMC
April 2018

Prediction of Protein-Protein Interactions.

Curr Protoc Bioinformatics 2017 12 8;60:8.2.1-8.2.14. Epub 2017 Dec 8.

Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1002/cpbi.38DOI Listing
December 2017

Modeling tumor progression via the comparison of stage-specific graphs.

Methods 2018 01 3;132:34-41. Epub 2017 Jul 3.

Princess Margaret Cancer Centre, UHN, 101 College Street, M5G 1L7, Toronto, Canada; TECHNA Institute for the Advancement of Technology for Health, UHN, 101 College Street, M5G 1L7, Toronto, Canada; Departments of Medical Biophysics and Computer Science, University of Toronto, Toronto, Canada; Institute of Neuroimmunology, Slovak Academy of Sciences, Bratislava, Slovakia. Electronic address:

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http://dx.doi.org/10.1016/j.ymeth.2017.06.033DOI Listing
January 2018

A Global Analysis of the Receptor Tyrosine Kinase-Protein Phosphatase Interactome.

Mol Cell 2017 Jan 5;65(2):347-360. Epub 2017 Jan 5.

Donnelly Centre, University of Toronto, Toronto, ON M5S 3E1, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada; Department of Biochemistry, University of Toronto, Toronto, ON M5S 1A8, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2016.12.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5663465PMC
January 2017

Systematic Identification of Oncogenic EGFR Interaction Partners.

J Mol Biol 2017 01 9;429(2):280-294. Epub 2016 Dec 9.

MRC Laboratory for Molecular Cell Biology, University College London, London, WC1E 6BT, UK. Electronic address:

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http://dx.doi.org/10.1016/j.jmb.2016.12.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5240790PMC
January 2017

pathDIP: an annotated resource for known and predicted human gene-pathway associations and pathway enrichment analysis.

Nucleic Acids Res 2017 01 28;45(D1):D419-D426. Epub 2016 Nov 28.

Department of Medical Biophysics, University of Toronto, Toronto, ON M5G 1L7, Canada

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http://dx.doi.org/10.1093/nar/gkw1082DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5210562PMC
January 2017

Circulating plant miRNAs can regulate human gene expression in vitro.

Sci Rep 2016 09 8;6:32773. Epub 2016 Sep 8.

IBM Life Sciences Discovery Centre, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1038/srep32773DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5015063PMC
September 2016

Reduced BRCA1 transcript levels in freshly isolated blood leukocytes from BRCA1 mutation carriers is mutation specific.

Breast Cancer Res 2016 08 17;18(1):87. Epub 2016 Aug 17.

Women's College Research Institute, Women's College Hospital, 76 Grenville Street, 6th Floor, Toronto, ON, Canada.

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http://dx.doi.org/10.1186/s13058-016-0739-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4989508PMC
August 2016

Quantification of angiotensin II-regulated proteins in urine of patients with polycystic and other chronic kidney diseases by selected reaction monitoring.

Clin Proteomics 2016 5;13:16. Epub 2016 Aug 5.

Division of Nephrology, Department of Medicine, Toronto General Hospital, University Health Network, University of Toronto, 11-PMB-189, 585 University Avenue, Toronto, ON M5G 2N2 Canada ; Toronto General Research Institute, University Health Network, Toronto, Canada.

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http://dx.doi.org/10.1186/s12014-016-9117-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4974759PMC
August 2016

Robust quantitative scratch assay.

Bioinformatics 2016 05 31;32(9):1439-40. Epub 2015 Dec 31.

Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada, Princess Margaret Cancer Centre and Techna, University Health Network, Toronto, ON, Canada, Department of Computer Science, University of Toronto, Toronto, ON, Canada.

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http://dx.doi.org/10.1093/bioinformatics/btv746DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4848397PMC
May 2016

Fundamentals of protein interaction network mapping.

Mol Syst Biol 2015 Dec 17;11(12):848. Epub 2015 Dec 17.

Donnelly Centre, Department of Biochemistry, Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4704491PMC
http://dx.doi.org/10.15252/msb.20156351DOI Listing
December 2015

Uninterrupted Sedentary Behavior Downregulates BRCA1 Gene Expression.

Cancer Prev Res (Phila) 2016 Jan 2;9(1):83-8. Epub 2015 Nov 2.

Women's College Research Institute, Women's College Hospital, Toronto, Ontario, Canada. Department of Nutritional Sciences, University of Toronto, Toronto, Ontario, Canada. Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1158/1940-6207.CAPR-15-0291DOI Listing
January 2016

Integrated interactions database: tissue-specific view of the human and model organism interactomes.

Nucleic Acids Res 2016 Jan 29;44(D1):D536-41. Epub 2015 Oct 29.

Princess Margaret Cancer Centre, University Health Network, Toronto, ON, M5G 1L7, Canada Departments of Medical Biophysics and Computer Science, University of Toronto, Toronto, ON, M5S 1A4, Canada

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http://dx.doi.org/10.1093/nar/gkv1115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4702811PMC
January 2016

Clinical Utility of Patient-Derived Xenografts to Determine Biomarkers of Prognosis and Map Resistance Pathways in EGFR-Mutant Lung Adenocarcinoma.

J Clin Oncol 2015 Aug 29;33(22):2472-80. Epub 2015 Jun 29.

Erin L. Stewart, Celine Mascaux, Nhu-An Pham, Shingo Sakashita, Jenna Sykes, Lucia Kim, Naoki Yanagawa, Ghassan Allo, Kota Ishizawa, Dennis Wang, Chang-Qi Zhu, Ming Li, Christine Ng, Ni Liu, Melania Pintilie, Petra Martin, Tom John, Igor Jurisica, Natasha B. Leighl, Benjamin G. Neel, Thomas K. Waddell, Frances A. Shepherd, Geoffrey Liu, Ming-Sound Tsao, Princess Margaret Cancer Centre, University Health Network, University of Toronto, Toronto, Ontario, Canada; Lucia Kim, Inha University College of Medicine, Incheon, South Korea; and Tom John, Austin Hospital, Heidelberg, Australia.

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http://jco.ascopubs.org/content/33/22/2472.full.pdf
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http://200.40.135.66:90/toc/0873/2015/0873-20150801-22-09.pd
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http://jco.ascopubs.org/cgi/doi/10.1200/JCO.2014.60.1492
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http://dx.doi.org/10.1200/JCO.2014.60.1492DOI Listing
August 2015

Prioritizing therapeutics for lung cancer: an integrative meta-analysis of cancer gene signatures and chemogenomic data.

PLoS Comput Biol 2015 Mar 18;11(3):e1004068. Epub 2015 Mar 18.

Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada; Department of Computer Science, University of Toronto, Toronto, Ontario, Canada; Techna Institute, University Health Network, Toronto, Ontario, Canada.

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https://dx.plos.org/10.1371/journal.pcbi.1004068
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http://dx.doi.org/10.1371/journal.pcbi.1004068DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4364883PMC
March 2015

Potential role of CC chemokine receptor 6 in prediction of late-onset cytomegalovirus infection following solid organ transplant.

Clin Transplant 2015 Jun 22;29(6):492-8. Epub 2015 Apr 22.

Transplant Infectious Diseases, Multi-Organ Transplant Program, University Health Network, University of Toronto, Toronto, ON, Canada.

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http://doi.wiley.com/10.1111/ctr.12531
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http://dx.doi.org/10.1111/ctr.12531DOI Listing
June 2015

Integrating RAS status into prognostic signatures for adenocarcinomas of the lung.

Clin Cancer Res 2015 Mar 21;21(6):1477-86. Epub 2015 Jan 21.

Informatics and Biocomputing Program, Ontario Institute for Cancer Research, Toronto, Canada. Princess Margaret Cancer Centre, University Health Network, Toronto, Canada. Department of Medical Biophysics, University of Toronto, Toronto, Canada. Department of Pharmacology and Toxicology, University of Toronto, Toronto, Canada.

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http://dx.doi.org/10.1158/1078-0432.CCR-14-1749DOI Listing
March 2015

BioID identifies novel c-MYC interacting partners in cultured cells and xenograft tumors.

J Proteomics 2015 Apr 18;118:95-111. Epub 2014 Oct 18.

Princess Margaret Cancer Centre, University Health Network, and Department of Medical Biophysics, University of Toronto, Toronto, ON Canada. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S18743919140046
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http://dx.doi.org/10.1016/j.jprot.2014.09.029DOI Listing
April 2015

NBN gain is predictive for adverse outcome following image-guided radiotherapy for localized prostate cancer.

Oncotarget 2014 Nov;5(22):11081-90

Departments of Radiation Oncology, Medical Biophysics, Medical Oncology, Laboratory Medicine and Pathology, Pharmacology & Toxicology and Biostatistics, Computer Science, University of Toronto, Toronto, ON, Canada. Radiation Medicine Program, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.

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http://www.oncotarget.com/fulltext/2404
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4294365PMC
http://dx.doi.org/10.18632/oncotarget.2404DOI Listing
November 2014

In silico prediction of physical protein interactions and characterization of interactome orphans.

Nat Methods 2015 Jan 17;12(1):79-84. Epub 2014 Nov 17.

1] Princess Margaret Cancer Center, University Health Network, Toronto, Ontario, Canada. [2] Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada. [3] Department of Computer Science, University of Toronto, Toronto, Ontario, Canada. [4] TECHNA Institute for the Advancement of Technology for Health, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1038/nmeth.3178DOI Listing
January 2015

Smoking status impacts microRNA mediated prognosis and lung adenocarcinoma biology.

BMC Cancer 2014 Oct 24;14:778. Epub 2014 Oct 24.

Department of Integrative Oncology, British Columbia Cancer Research Centre, Vancouver, British Columbia V5Z 1L3, Canada.

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http://dx.doi.org/10.1186/1471-2407-14-778DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4216369PMC
October 2014

Comparative network analysis via differential graphlet communities.

Proteomics 2015 Jan 15;15(2-3):608-17. Epub 2014 Dec 15.

Department of Computer Science and Engineering, York University, Toronto, Canada; Princess Margaret Cancer Centre, TECHNA Institute for the Advancement of Technology for Health, UHN, Toronto, Canada.

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http://dx.doi.org/10.1002/pmic.201400233DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4309523PMC
January 2015

Myc and its interactors take shape.

Biochim Biophys Acta 2015 May 14;1849(5):469-83. Epub 2014 Jun 14.

Department of Medical Biophysics, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.bbagrm.2014.06.002DOI Listing
May 2015

The mammalian-membrane two-hybrid assay (MaMTH) for probing membrane-protein interactions in human cells.

Nat Methods 2014 May 23;11(5):585-92. Epub 2014 Mar 23.

1] Donnelly Centre, University of Toronto, Toronto, Ontario, Canada. [2] Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada. [3] Department of Biochemistry, University of Toronto, Toronto, Ontario, Canada.

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http://www.nature.com/articles/nmeth.2895
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http://dx.doi.org/10.1038/nmeth.2895DOI Listing
May 2014

CHIP-MYTH: a novel interactive proteomics method for the assessment of agonist-dependent interactions of the human β₂-adrenergic receptor.

Biochem Biophys Res Commun 2014 Mar 19;445(4):746-56. Epub 2014 Feb 19.

Donnelly Centre, University of Toronto, Ontario, Canada; Department of Molecular Genetics, University of Toronto, Ontario, Canada; Department of Biochemistry, University of Toronto, Ontario, Canada. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S0006291X140028
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http://dx.doi.org/10.1016/j.bbrc.2014.02.033DOI Listing
March 2014

Integration, visualization and analysis of human interactome.

Biochem Biophys Res Commun 2014 Mar 1;445(4):757-73. Epub 2014 Feb 1.

Princess Margaret Cancer Centre, University Health Network and TECHNA Institute for the Advancement of Technology for Health, TMDT, Room 11-314, 101 College Street, Toronto, ON M5G 1L7, Canada; University of Toronto, Department of Medical Biophysics, Toronto, ON, Canada; University of Toronto, Department of Computer Science, Toronto, ON, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.bbrc.2014.01.151DOI Listing
March 2014

Validation of a histology-independent prognostic gene signature for early-stage, non-small-cell lung cancer including stage IA patients.

J Thorac Oncol 2014 Jan;9(1):59-64

*Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada; and Departments of †Computer Science, ‡Medical Biophysics, §Medicine, and ‖Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada.

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https://linkinghub.elsevier.com/retrieve/pii/S15560864153016
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http://dx.doi.org/10.1097/JTO.0000000000000042DOI Listing
January 2014

Identifying Myc interactors.

Methods Mol Biol 2013 ;1012:51-64

Ontario Cancer Institute, The Campbell Family Institute for Cancer Research, Toronto, ON, Canada.

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http://dx.doi.org/10.1007/978-1-62703-429-6_4DOI Listing
March 2014

Novel semantic similarity measure improves an integrative approach to predicting gene functional associations.

BMC Syst Biol 2013 Mar 14;7:22. Epub 2013 Mar 14.

Ontario Cancer Institute and Campbell Family Cancer Research Institute, Princess Margaret Cancer Centre, University Health Network, Toronto, Canada.

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http://dx.doi.org/10.1186/1752-0509-7-22DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3663825PMC
March 2013

Integrative cancer informatics for the identification of prognostic and predictive biomarkers.

Authors:
Igor Jurisica

BMC Proc 2013 4;7 Suppl 2:K7. Epub 2013 Apr 4.

Ontario Cancer Institute and University Health Network, University of Toronto, Canada.

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http://dx.doi.org/10.1186/1753-6561-7-S2-K7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3624142PMC
April 2015

NetwoRx: connecting drugs to networks and phenotypes in Saccharomyces cerevisiae.

Nucleic Acids Res 2013 Jan 29;41(Database issue):D720-7. Epub 2012 Nov 29.

Department of Medical Biophysics, University of Toronto, Toronto, ON M5G 2M9, Canada.

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http://dx.doi.org/10.1093/nar/gks1106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3531049PMC
January 2013

Exploiting the noise: improving biomarkers with ensembles of data analysis methodologies.

Genome Med 2012 12;4(11):84. Epub 2012 Nov 12.

Informatics and Biocomputing Platform, Ontario Institute for Cancer Research, Toronto, ON, M5G 0A3, Canada ; Department of Medical Biophysics, University of Toronto, Toronto, ON, M5G 2M9, Canada.

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http://genomemedicine.biomedcentral.com/articles/10.1186/gm3
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http://dx.doi.org/10.1186/gm385DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3580418PMC
May 2014

Network-based characterization of drug-regulated genes, drug targets, and toxicity.

Methods 2012 Aug 27;57(4):499-507. Epub 2012 Jun 27.

The Campbell Family Institute for Cancer Research, Ontario Cancer Institute, University Health Network, IBM Life Sciences Discovery Centre, Toronto Medical Discovery Tower, 9-305, 101 College Street, Toronto, Ontario, M5G 1L7, Canada.

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http://dx.doi.org/10.1016/j.ymeth.2012.06.003DOI Listing
August 2012

In silico drug screen in mouse liver identifies candidate calorie restriction mimetics.

Rejuvenation Res 2012 Apr;15(2):148-52

Department of Medical Biophysics, University of Toronto, Ontario, Canada.

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http://dx.doi.org/10.1089/rej.2011.1263DOI Listing
April 2012

Comparison of whole genome amplification methods for analysis of DNA extracted from microdissected early breast lesions in formalin-fixed paraffin-embedded tissue.

ISRN Oncol 2012 14;2012:710692. Epub 2012 Mar 14.

Division of Applied Molecular Oncology, Ontario Cancer Institute, Princess Margaret Hospital, Toronto, ON, Canada M5G 2M9.

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http://dx.doi.org/10.5402/2012/710692DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3317021PMC
August 2012

Allelic loss of the loci containing the androgen synthesis gene, StAR, is prognostic for relapse in intermediate-risk prostate cancer.

Prostate 2012 Sep 27;72(12):1295-305. Epub 2011 Dec 27.

Department of Radiation Oncology, Medical Biophysics, Laboratory Medicine and Pathology, Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada.

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http://doi.wiley.com/10.1002/pros.22478
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http://dx.doi.org/10.1002/pros.22478DOI Listing
September 2012

The murine caecal microRNA signature depends on the presence of the endogenous microbiota.

Int J Biol Sci 2012 19;8(2):171-86. Epub 2011 Dec 19.

Department of Nutritional Sciences, University of Toronto, Ontario, Canada.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3248702PMC
http://dx.doi.org/10.7150/ijbs.8.171DOI Listing
September 2012

Optimized application of penalized regression methods to diverse genomic data.

Bioinformatics 2011 Dec;27(24):3399-406

Department of Biostatistics, Harvard School of Public Health, Boston, MA, USA.

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http://dx.doi.org/10.1093/bioinformatics/btr591DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3232376PMC
December 2011

Protein complex prediction with RNSC.

Methods Mol Biol 2012 ;804:297-312

Department of Industrial Engineering and Operations Research, Columbia University, New York, NY, USA.

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http://dx.doi.org/10.1007/978-1-61779-361-5_16DOI Listing
March 2012

Algorithms for systematic identification of small subgraphs.

Methods Mol Biol 2012 ;804:219-44

Ontario Cancer Institute/UHN, Toronto, ON, Canada.

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http://dx.doi.org/10.1007/978-1-61779-361-5_12DOI Listing
March 2012

SCRIPDB: a portal for easy access to syntheses, chemicals and reactions in patents.

Nucleic Acids Res 2012 Jan 8;40(Database issue):D428-33. Epub 2011 Nov 8.

Department of Computer Science, University of Toronto, Toronto, Ontario M5G 1L7, Canada.

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http://dx.doi.org/10.1093/nar/gkr919DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3245107PMC
January 2012

Stem cell gene expression programs influence clinical outcome in human leukemia.

Nat Med 2011 Aug 28;17(9):1086-93. Epub 2011 Aug 28.

Division of Stem Cell and Developmental Biology, Campbell Family Institute for Cancer Research, Ontario Cancer Institute, University Health Network and Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.

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http://www.nature.com/articles/nm.2415
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http://dx.doi.org/10.1038/nm.2415DOI Listing
August 2011

Automated microinjection of recombinant BCL-X into mouse zygotes enhances embryo development.

PLoS One 2011 20;6(7):e21687. Epub 2011 Jul 20.

Department of Mechanical and Industrial Engineering and Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, Ontario, Canada.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0021687PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3140481PMC
December 2011

Isolation of single human hematopoietic stem cells capable of long-term multilineage engraftment.

Science 2011 Jul;333(6039):218-21

Division of Stem Cell and Developmental Biology, Campbell Family Institute for Cancer Research/Ontario Cancer Institute, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1126/science.1201219DOI Listing
July 2011