Publications by authors named "Ignacio Wistuba"

100Publications

Molecular differences across invasive lung adenocarcinoma morphological subgroups.

Transl Lung Cancer Res 2020 Aug;9(4):1029-1040

Quantitative Biomedical Research Center, Department of Population and Data Sciences, University of Texas Southwestern Medical Center, Dallas, TX, USA.

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http://dx.doi.org/10.21037/tlcr-19-321DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7481608PMC
August 2020

Transition from a Standard to a Hybrid On-Site and Remote Anatomic Pathology Training Model During the COVID-19 Pandemic.

Arch Pathol Lab Med 2020 Sep 16. Epub 2020 Sep 16.

Departments of Pathology (Chin, Kwon, Gan, Ramalingam, Prieto, Aung) and Translational Molecular Pathology (Wistuba), at The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

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http://dx.doi.org/10.5858/arpa.2020-0467-SADOI Listing
September 2020

Female Gender Predicts Augmented Immune Infiltration in Lung Adenocarcinoma.

Clin Lung Cancer 2020 Jun 14. Epub 2020 Jun 14.

Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX; Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX.

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http://dx.doi.org/10.1016/j.cllc.2020.06.003DOI Listing
June 2020

A Phase II Trial of Alisertib (MLN8237) in Salvage Malignant Mesothelioma.

Oncologist 2020 Jul 1. Epub 2020 Jul 1.

Department of Thoracic/Head & Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

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http://dx.doi.org/10.1634/theoncologist.2020-0610DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7543335PMC
July 2020

An in vivo functional genomics screen of nuclear receptors and their co-regulators identifies FOXA1 as an essential gene in lung tumorigenesis.

Neoplasia 2020 08 13;22(8):294-310. Epub 2020 May 13.

Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, TX, USA; Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX, USA; Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA; Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neo.2020.04.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7281309PMC
August 2020

LKB1/STK11 Expression in Lung Adenocarcinoma and Associations With Patterns of Recurrence.

Ann Thorac Surg 2020 10 19;110(4):1131-1138. Epub 2020 May 19.

Department of Thoracic and Cardiovascular Surgery, University of Texas MD Anderson Cancer Center, Houston, Texas. Electronic address:

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http://dx.doi.org/10.1016/j.athoracsur.2020.03.114DOI Listing
October 2020

T-Cell Repertoire in Combination with T-Cell Density Predicts Clinical Outcomes in Patients with Merkel Cell Carcinoma.

J Invest Dermatol 2020 Nov 15;140(11):2146-2156.e4. Epub 2020 Apr 15.

Department of Pathology and Laboratory Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA; Department of Translational and Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jid.2020.02.031DOI Listing
November 2020

Computational Staining of Pathology Images to Study the Tumor Microenvironment in Lung Cancer.

Cancer Res 2020 05 8;80(10):2056-2066. Epub 2020 Jan 8.

Quantitative Biomedical Research Center, Department of Population and Data Sciences, University of Texas Southwestern Medical Center, Dallas, Texas.

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http://dx.doi.org/10.1158/0008-5472.CAN-19-1629DOI Listing
May 2020

RUVBL1/RUVBL2 ATPase Activity Drives PAQosome Maturation, DNA Replication and Radioresistance in Lung Cancer.

Cell Chem Biol 2020 01 26;27(1):105-121.e14. Epub 2019 Dec 26.

Eugene McDermott Center for Human Growth and Development, UT Southwestern Medical Center, Dallas, TX 75390, USA; Department of Pharmacology, UT Southwestern Medical Center, Dallas, TX 75390, USA; Harold C. Simmons Comprehensive Cancer Center, UT Southwestern Medical Center, Dallas, TX 75390, USA. Electronic address:

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http://dx.doi.org/10.1016/j.chembiol.2019.12.005DOI Listing
January 2020

ConvPath: A software tool for lung adenocarcinoma digital pathological image analysis aided by a convolutional neural network.

EBioMedicine 2019 Dec 22;50:103-110. Epub 2019 Nov 22.

Quantitative Biomedical Research Center, Department of Population and Data Sciences, University of Texas Southwestern Medical Center, Dallas, TX; Department of Bioinformatics, University of Texas Southwestern Medical Center, Dallas, TX; Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX. Electronic address:

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http://dx.doi.org/10.1016/j.ebiom.2019.10.033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6921240PMC
December 2019

Artificial Intelligence in Lung Cancer Pathology Image Analysis.

Cancers (Basel) 2019 Oct 28;11(11). Epub 2019 Oct 28.

Quantitative Biomedical Research Center, Department of Population and Data Sciences, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

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http://dx.doi.org/10.3390/cancers11111673DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6895901PMC
October 2019

Multiplex Immunofluorescence Assays.

Methods Mol Biol 2020 ;2055:467-495

Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

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http://dx.doi.org/10.1007/978-1-4939-9773-2_22DOI Listing
January 2020

Correction: LCE: an open web portal to explore gene expression and clinical associations in lung cancer.

Oncogene 2020 Jan;39(3):718-719

Quantitative Biomedical Research Center, Department of Clinical Sciences, UT Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX, 75390, USA.

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http://dx.doi.org/10.1038/s41388-019-1000-6DOI Listing
January 2020

Non-invasive genotyping of metastatic colorectal cancer using circulating cell free DNA.

Cancer Genet 2019 09 12;237:82-89. Epub 2019 Jun 12.

Department of Translational Molecular Pathology, Division of Pathology and Laboratory Medicine, The University of Texas M.D. Anderson Cancer Center, 6565 MD Anderson Blvd., Houston, TX 77030, United States; Department of Hematopathology, The University of Texas M.D. Anderson Cancer Center, Houston, TX, United States. Electronic address:

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http://dx.doi.org/10.1016/j.cancergen.2019.06.004DOI Listing
September 2019

Development and Application of Duplex Sequencing Strategy for Cell-Free DNA-Based Longitudinal Monitoring of Stage IV Colorectal Cancer.

J Mol Diagn 2019 11 8;21(6):994-1009. Epub 2019 Aug 8.

Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas; Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, Texas. Electronic address:

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http://dx.doi.org/10.1016/j.jmoldx.2019.06.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6854476PMC
November 2019

Removal of N-Linked Glycosylation Enhances PD-L1 Detection and Predicts Anti-PD-1/PD-L1 Therapeutic Efficacy.

Cancer Cell 2019 08 18;36(2):168-178.e4. Epub 2019 Jul 18.

Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA; Graduate Institute of Biomedical Sciences and Center for Molecular Medicine, China Medical University, Taichung 404, Taiwan; Department of Biotechnology, Asia University, Taichung 413, Taiwan; Graduate School of Biomedical Sciences, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2019.06.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6793936PMC
August 2019

Sphingosine Kinase 1 Signaling Promotes Metastasis of Triple-Negative Breast Cancer.

Cancer Res 2019 08 25;79(16):4211-4226. Epub 2019 Jun 25.

Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.

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http://dx.doi.org/10.1158/0008-5472.CAN-18-3803DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6697620PMC
August 2019

Tumor cellular proliferation is associated with enhanced immune checkpoint expression in stage I non-small cell lung cancer.

J Thorac Cardiovasc Surg 2019 09 17;158(3):911-919.e6. Epub 2019 May 17.

Department of Thoracic and Cardiovascular Surgery, University of Texas MD Anderson Cancer Center, Houston, Tex. Electronic address:

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http://dx.doi.org/10.1016/j.jtcvs.2019.04.084DOI Listing
September 2019

Development and Validation of a Pathology Image Analysis-based Predictive Model for Lung Adenocarcinoma Prognosis - A Multi-cohort Study.

Sci Rep 2019 05 3;9(1):6886. Epub 2019 May 3.

Quantitative Biomedical Research Center, Department of Clinical Sciences, University of Texas Southwestern Medical Center, Dallas, Texas, 75390, USA.

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http://dx.doi.org/10.1038/s41598-019-42845-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6499884PMC
May 2019

Genomic landscape of allelic imbalance in premalignant atypical adenomatous hyperplasias of the lung.

EBioMedicine 2019 Apr 21;42:296-303. Epub 2019 Mar 21.

Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA; The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences, Houston, TX, USA; Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ebiom.2019.03.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6491940PMC
April 2019

Rational "Error Elimination" Approach to Evaluating Molecular Barcoded Next-Generation Sequencing Data Identifies Low-Frequency Mutations in Hematologic Malignancies.

J Mol Diagn 2019 05 20;21(3):471-482. Epub 2019 Feb 20.

Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas; Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, Texas. Electronic address:

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http://dx.doi.org/10.1016/j.jmoldx.2019.01.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6521894PMC
May 2019

State-of-the-Art of Profiling Immune Contexture in the Era of Multiplexed Staining and Digital Analysis to Study Paraffin Tumor Tissues.

Cancers (Basel) 2019 Feb 20;11(2). Epub 2019 Feb 20.

Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, 2130 West Holcombe Blvd, Houston, TX 77030, USA.

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http://dx.doi.org/10.3390/cancers11020247DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6406364PMC
February 2019

Centrifuged supernatants from FNA provide a liquid biopsy option for clinical next-generation sequencing of thyroid nodules.

Cancer Cytopathol 2019 03 8;127(3):146-160. Epub 2019 Jan 8.

Department of Pathology, Division of Pathology and Laboratory Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas.

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http://dx.doi.org/10.1002/cncy.22098DOI Listing
March 2019

PI3-kinase pathway biomarkers in oral cancer and tumor immune cells.

Head Neck 2019 03 16;41(3):615-622. Epub 2018 Dec 16.

The University of Texas MD Anderson Cancer Center, Department of Thoracic/Head and Neck Medical Oncology.

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http://dx.doi.org/10.1002/hed.25350DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6382518PMC
March 2019

LCE: an open web portal to explore gene expression and clinical associations in lung cancer.

Oncogene 2019 04 7;38(14):2551-2564. Epub 2018 Dec 7.

Quantitative Biomedical Research Center, Department of Clinical Sciences, UT Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX, 75390, USA.

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http://dx.doi.org/10.1038/s41388-018-0588-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6477796PMC
April 2019

Transcriptome Deconvolution of Heterogeneous Tumor Samples with Immune Infiltration.

iScience 2018 Nov 2;9:451-460. Epub 2018 Nov 2.

Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA. Electronic address:

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http://dx.doi.org/10.1016/j.isci.2018.10.028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6249353PMC
November 2018

Reply to Oegema et al.: CFI-400945 and Polo-like kinase 4 inhibition.

Proc Natl Acad Sci U S A 2018 11 30;115(46):E10810-E10811. Epub 2018 Oct 30.

Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030.

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http://dx.doi.org/10.1073/pnas.1813967115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6243257PMC
November 2018