Ignacio Varela

Ignacio Varela

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Ignacio Varela

Ignacio Varela

Publications by authors named "Ignacio Varela"

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Analysis pipelines for cancer genome sequencing in mice.

Nat Protoc 2020 Feb 6;15(2):266-315. Epub 2020 Jan 6.

Institute of Molecular Oncology and Functional Genomics, School of Medicine, Technische Universität München, Munich, Germany.

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http://dx.doi.org/10.1038/s41596-019-0234-7DOI Listing
February 2020

The MNT transcription factor autoregulates its expression and supports proliferation in MYC-associated factor X (MAX)-deficient cells.

J Biol Chem 2020 Feb 9;295(7):2001-2017. Epub 2020 Jan 9.

Instituto de Biomedicina y Biotecnología de Cantabria (IBBTEC), Universidad de Cantabria-CSIC, and Department of Molecular Biology, Universidad de Cantabria, 39005 Santander, Spain

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http://dx.doi.org/10.1074/jbc.RA119.010389DOI Listing
February 2020

Bone Marrow Clonogenic Myeloid Progenitors from -Mutated AML Patients Do Not Harbor the Mutation: Implication for the Cell-Of-Origin of AML.

Genes (Basel) 2020 01 9;11(1). Epub 2020 Jan 9.

Department of Biomedicine, Josep Carreras Leukemia Research Institute, School of Medicine, University of Barcelona, Barcelona 08036, Spain.

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http://dx.doi.org/10.3390/genes11010073DOI Listing
January 2020

Tumor Functional Heterogeneity Unraveled by scRNA-seq Technologies.

Trends Cancer 2020 Jan 3;6(1):13-19. Epub 2020 Jan 3.

Instituto de Biomedicina y Biotecnología de Cantabria, Universidad de Cantabria - CSIC, Santander, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.trecan.2019.11.010DOI Listing
January 2020

Intratumoral heterogeneity and clonal evolution in blood malignancies and solid tumors.

Oncotarget 2017 Sep 16;8(39):66742-66746. Epub 2017 Aug 16.

Hematology Research Group, IIS La Fe, Valencia, Spain.

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http://dx.doi.org/10.18632/oncotarget.20279DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5630451PMC
September 2017

Evaluation of Toll-like-receptor gene family variants as prognostic biomarkers in rheumatoid arthritis.

Immunol Lett 2017 07 7;187:35-40. Epub 2017 May 7.

Unidad de Genética, Hospital Universitario Marqués de Valdecilla-Instituto de Investigación Valdecilla (IDIVAL), Santander, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.imlet.2017.04.011DOI Listing
July 2017

Rapid parallel acquisition of somatic mutations after NPM1 in acute myeloid leukaemia evolution.

Br J Haematol 2017 03 7;176(5):825-829. Epub 2016 Apr 7.

Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, UK.

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http://dx.doi.org/10.1111/bjh.13999DOI Listing
March 2017

Development Refractoriness of MLL-Rearranged Human B Cell Acute Leukemias to Reprogramming into Pluripotency.

Stem Cell Reports 2016 10 22;7(4):602-618. Epub 2016 Sep 22.

Josep Carreras Leukemia Research Institute, School of Medicine, University of Barcelona, Casanova 143, 08036 Barcelona, Spain; Department of Biomedicine, School of Medicine, University of Barcelona, 08036 Barcelona, Spain; Instituciò Catalana de Recerca i Estudis Avançats (ICREA), 08036 Barcelona, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.stemcr.2016.08.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5063541PMC
October 2016

A functional variant of TLR10 modifies the activity of NFkB and may help predict a worse prognosis in patients with rheumatoid arthritis.

Arthritis Res Ther 2016 10 4;18(1):221. Epub 2016 Oct 4.

Unidad de Genética, Hospital Universitario Marques de Valdecilla-Instituto de Investigación Valdecilla (IDIVAL), Avenida Valdecilla s/n, 39008, Santander, Spain.

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http://dx.doi.org/10.1186/s13075-016-1113-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5050569PMC
October 2016

Identification of a germline F692L drug resistance variant in cis with Flt3-internal tandem duplication in knock-in mice.

Haematologica 2016 08 12;101(8):e328-31. Epub 2016 May 12.

The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge, UK Department of Haematology, Cambridge University Hospitals NHS Trust, UK

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http://dx.doi.org/10.3324/haematol.2016.146159DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4967582PMC
August 2016

Development and validation of a comprehensive genomic diagnostic tool for myeloid malignancies.

Blood 2016 07 27;128(1):e1-9. Epub 2016 Apr 27.

Wellcome Trust Sanger Institute, Hinxton, Cambridge, United Kingdom; Department of Haematology, Haemato-oncology Diagnostic Service, Cambridge University Hospitals National Health Service Trust, Cambridge, United Kingdom; Department of Haematology, University of Cambridge, Cambridge, United Kingdom;

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http://dx.doi.org/10.1182/blood-2015-11-683334DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4937362PMC
July 2016

Activated KRAS Cooperates with MLL-AF4 to Promote Extramedullary Engraftment and Migration of Cord Blood CD34+ HSPC But Is Insufficient to Initiate Leukemia.

Cancer Res 2016 04 2;76(8):2478-89. Epub 2016 Feb 2.

Josep Carreras Leukemia Research Institute and Department of Biomedicine, School of Medicine, University of Barcelona, Barcelona, Spain. Instituciò Catalana Recerca i Estudis Avançats (ICREA), Barcelona, Spain.

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http://dx.doi.org/10.1158/0008-5472.CAN-15-2769DOI Listing
April 2016

Colorectal adenomas contain multiple somatic mutations that do not coincide with synchronous adenocarcinoma specimens.

PLoS One 2015 16;10(3):e0119946. Epub 2015 Mar 16.

Cancer Genomics Group, IDIVAL, Instituto de Investigación Marqués de Valdecilla, Santander, Spain; Department of Pathology, Hospital Universitario Marqués de Valdecilla, Santander, Spain.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0119946PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4361059PMC
January 2016

A Truncated Variant of ASCC1, a Novel Inhibitor of NF-κB, Is Associated with Disease Severity in Patients with Rheumatoid Arthritis.

J Immunol 2015 Dec 26;195(11):5415-20. Epub 2015 Oct 26.

Unidad de Genética, Hospital Universitario Marques de Valdecilla-Instituto de Investigación Valdecilla, 39011 Santander, Spain;

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http://dx.doi.org/10.4049/jimmunol.1501532DOI Listing
December 2015

Leukemia-associated somatic mutations drive distinct patterns of age-related clonal hemopoiesis.

Cell Rep 2015 Mar 26;10(8):1239-45. Epub 2015 Feb 26.

Haematological Cancer Genetics, Wellcome Trust Sanger Institute, Cambridge CB10 1SA, UK; Department of Haematology, Cambridge Biomedical Campus, University of Cambridge, Cambridge CB2 0XY, UK; Department of Haematology, Cambridge University Hospitals NHS Trust, Cambridge CB2 0QQ, UK. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2015.02.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4542313PMC
March 2015

A novel mutation in ADAMTS13 of a child with Upshaw-Schulman Syndrome.

Thromb Haemost 2014 Nov 24;112(5):1065-8. Epub 2014 Jul 24.

Francisco Javier Batlle Fonrodona, MD, Servicio de Hematología y Hemoterapia, Complexo Hospitalario Universitario A Coruña, (Edificio Hospital Materno Infantil), Carretera del Pasaje s/n, 15006 - A Coruña, Spain, Tel.: +34 981 178000 Ext. 292113, Fax: +34 981 178392, E-mail:

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http://dx.doi.org/10.1160/TH14-02-0116DOI Listing
November 2014

Sin3b interacts with Myc and decreases Myc levels.

J Biol Chem 2014 Aug 20;289(32):22221-36. Epub 2014 Jun 20.

From the Instituto de Biomedicina y Biotecnología de Cantabria (IBBTEC), Consejo Superior de Investigaciones Científicas, Universidad de Cantabria, Sociedad para el Desarrollo de Cantabria and the Departamento de Biología Molecular, Universidad de Cantabria, Santander 39011, Spain,

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http://dx.doi.org/10.1074/jbc.M113.538744DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4139234PMC
August 2014

An international effort towards developing standards for best practices in analysis, interpretation and reporting of clinical genome sequencing results in the CLARITY Challenge.

Authors:
Catherine A Brownstein Alan H Beggs Nils Homer Barry Merriman Timothy W Yu Katherine C Flannery Elizabeth T DeChene Meghan C Towne Sarah K Savage Emily N Price Ingrid A Holm Lovelace J Luquette Elaine Lyon Joseph Majzoub Peter Neupert David McCallie Peter Szolovits Huntington F Willard Nancy J Mendelsohn Renee Temme Richard S Finkel Sabrina W Yum Livija Medne Shamil R Sunyaev Ivan Adzhubey Christopher A Cassa Paul I W de Bakker Hatice Duzkale Piotr Dworzyński William Fairbrother Laurent Francioli Birgit H Funke Monica A Giovanni Robert E Handsaker Kasper Lage Matthew S Lebo Monkol Lek Ignaty Leshchiner Daniel G MacArthur Heather M McLaughlin Michael F Murray Tune H Pers Paz P Polak Soumya Raychaudhuri Heidi L Rehm Rachel Soemedi Nathan O Stitziel Sara Vestecka Jochen Supper Claudia Gugenmus Bernward Klocke Alexander Hahn Max Schubach Mortiz Menzel Saskia Biskup Peter Freisinger Mario Deng Martin Braun Sven Perner Richard J H Smith Janeen L Andorf Jian Huang Kelli Ryckman Val C Sheffield Edwin M Stone Thomas Bair E Ann Black-Ziegelbein Terry A Braun Benjamin Darbro Adam P DeLuca Diana L Kolbe Todd E Scheetz Aiden E Shearer Rama Sompallae Kai Wang Alexander G Bassuk Erik Edens Katherine Mathews Steven A Moore Oleg A Shchelochkov Pamela Trapane Aaron Bossler Colleen A Campbell Jonathan W Heusel Anne Kwitek Tara Maga Karin Panzer Thomas Wassink Douglas Van Daele Hela Azaiez Kevin Booth Nic Meyer Michael M Segal Marc S Williams Gerard Tromp Peter White Donald Corsmeier Sara Fitzgerald-Butt Gail Herman Devon Lamb-Thrush Kim L McBride David Newsom Christopher R Pierson Alexander T Rakowsky Aleš Maver Luca Lovrečić Anja Palandačić Borut Peterlin Ali Torkamani Anna Wedell Mikael Huss Andrey Alexeyenko Jessica M Lindvall Måns Magnusson Daniel Nilsson Henrik Stranneheim Fulya Taylan Christian Gilissen Alexander Hoischen Bregje van Bon Helger Yntema Marcel Nelen Weidong Zhang Jason Sager Lu Zhang Kathryn Blair Deniz Kural Michael Cariaso Greg G Lennon Asif Javed Saloni Agrawal Pauline C Ng Komal S Sandhu Shuba Krishna Vamsi Veeramachaneni Ofer Isakov Eran Halperin Eitan Friedman Noam Shomron Gustavo Glusman Jared C Roach Juan Caballero Hannah C Cox Denise Mauldin Seth A Ament Lee Rowen Daniel R Richards F Anthony San Lucas Manuel L Gonzalez-Garay C Thomas Caskey Yu Bai Ying Huang Fang Fang Yan Zhang Zhengyuan Wang Jorge Barrera Juan M Garcia-Lobo Domingo González-Lamuño Javier Llorca Maria C Rodriguez Ignacio Varela Martin G Reese Francisco M De La Vega Edward Kiruluta Michele Cargill Reece K Hart Jon M Sorenson Gholson J Lyon David A Stevenson Bruce E Bray Barry M Moore Karen Eilbeck Mark Yandell Hongyu Zhao Lin Hou Xiaowei Chen Xiting Yan Mengjie Chen Cong Li Can Yang Murat Gunel Peining Li Yong Kong Austin C Alexander Zayed I Albertyn Kym M Boycott Dennis E Bulman Paul M K Gordon A Micheil Innes Bartha M Knoppers Jacek Majewski Christian R Marshall Jillian S Parboosingh Sarah L Sawyer Mark E Samuels Jeremy Schwartzentruber Isaac S Kohane David M Margulies

Genome Biol 2014 Mar 25;15(3):R53. Epub 2014 Mar 25.

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http://dx.doi.org/10.1186/gb-2014-15-3-r53DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4073084PMC
March 2014

Intratumor heterogeneity and branched evolution revealed by multiregion sequencing.

N Engl J Med 2012 Mar;366(10):883-892

Cancer Research UK London Research Institute (M. Gerlinger, A.J.R., S.H., D.E., E.G., P.M., N.M., A.S., B.P., S.B., N.Q.M., C.R.S., B.S.-D., G.C., G.S., J.D., C.S.), Royal Marsden Hospital Department of Medicine (J.L., M.N., L.P., G.S., M. Gore), Wellcome Trust Sanger Institute (P.T., I.V., A.B., D.J., K.R., C.L., P.A.F.), Barts Cancer Institute at the Barts and the London School of Medicine and Dentistry (M. Gerlinger), and the University College London Cancer Institute (C.S.) - all in London; the Technical University of Denmark, Lyngby (A.C.E., Z.S.); and Harvard Medical School, Boston (Z.S.). Address reprint requests to Dr. Swanton at the Cancer Research UK London Research Institute, Translational Cancer Therapeutics Laboratory, 44 Lincoln's Inn Fields, London WC2A 3LY, United Kingdom, or at

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http://dx.doi.org/10.1056/NEJMoa1113205DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4878653PMC
March 2012

Aging and chronic DNA damage response activate a regulatory pathway involving miR-29 and p53.

EMBO J 2011 Jun 26;30(11):2219-32. Epub 2011 Apr 26.

Departamento de Bioquímica y Biología Molecular, Instituto Universitario de Oncología, Universidad de Oviedo, Oviedo, Spain.

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http://dx.doi.org/10.1038/emboj.2011.124DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3117645PMC
June 2011

Nuclear envelope alterations generate an aging-like epigenetic pattern in mice deficient in Zmpste24 metalloprotease.

Aging Cell 2010 Dec 21;9(6):947-57. Epub 2010 Oct 21.

Departamento de Bioquímica y Biología Molecular Unidad de Epigenética, Instituto Universitario de Oncología, Universidad de Oviedo, 33006-Oviedo, Spain.

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http://dx.doi.org/10.1111/j.1474-9726.2010.00621.xDOI Listing
December 2010

Premature aging in mice activates a systemic metabolic response involving autophagy induction.

Hum Mol Genet 2008 Jul 28;17(14):2196-211. Epub 2008 Apr 28.

Departamento de Bioquímica y Biología Molecular, Facultad de Medicina, Instituto Universitario de Oncología, Universidad de Oviedo, 33006 Oviedo, Spain.

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http://dx.doi.org/10.1093/hmg/ddn120DOI Listing
July 2008

Combined treatment with statins and aminobisphosphonates extends longevity in a mouse model of human premature aging.

Nat Med 2008 Jul 29;14(7):767-72. Epub 2008 Jun 29.

Departamento de Bioquímica y Biología Molecular, Facultad de Medicina, Instituto Universitario de Oncología, Universidad de Oviedo, calle Fernando, Bongera s/n, 33006-Oviedo, Spain.

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http://dx.doi.org/10.1038/nm1786DOI Listing
July 2008

Nuclear envelope defects cause stem cell dysfunction in premature-aging mice.

J Cell Biol 2008 Apr 31;181(1):27-35. Epub 2008 Mar 31.

Departamento de Bioquímica y Biología Molecular, Facultad de Medicina, Instituto Universitario de Oncología, Universidad de Oviedo, 33006 Oviedo, Spain.

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http://jcb.rupress.org/content/181/1/27.full.pdf
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http://www.jcb.org/lookup/doi/10.1083/jcb.200801096
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http://dx.doi.org/10.1083/jcb.200801096DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2287278PMC
April 2008

From immature lamin to premature aging: molecular pathways and therapeutic opportunities.

Cell Cycle 2005 Dec 23;4(12):1732-5. Epub 2005 Dec 23.

Departamento de Bioquímica y Biología Molecular, Instituto Universitario de Oncología, Universidad de Oviedo, Oviedo, Spain.

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http://dx.doi.org/10.4161/cc.4.12.2202DOI Listing
December 2005

Accelerated ageing in mice deficient in Zmpste24 protease is linked to p53 signalling activation.

Nature 2005 Sep 3;437(7058):564-8. Epub 2005 Aug 3.

Departamento de Bioquímica y Biología Molecular, Facultad de Medicina, Instituto Universitario de Oncología, Universidad de Oviedo, 33006 Oviedo, Spain.

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http://dx.doi.org/10.1038/nature04019DOI Listing
September 2005

AtFACE-2, a functional prenylated protein protease from Arabidopsis thaliana related to mammalian Ras-converting enzymes.

J Biol Chem 2003 Oct 19;278(43):42091-7. Epub 2003 Aug 19.

Departamento de Bioquímica y Biología Molecular, Instituto Universitario de Oncología, Universidad de Oviedo, Campus del Christo, 33006-Oviedo, Spain.

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http://dx.doi.org/10.1074/jbc.M306700200DOI Listing
October 2003

Identification, functional expression and enzymic analysis of two distinct CaaX proteases from Caenorhabditis elegans.

Biochem J 2003 Mar;370(Pt 3):1047-54

Departamento de Bioqumica y Biología Molecular, Instituto Universitario de Oncología, Universidad de Oviedo, Campus del Cristo, 33006 Oviedo, Spain.

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http://dx.doi.org/10.1042/BJ20021514DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1223240PMC
March 2003