Ignacio Munoz-Sanjuan

Ignacio Munoz-Sanjuan

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Ignacio Munoz-Sanjuan

Ignacio Munoz-Sanjuan

Publications by authors named "Ignacio Munoz-Sanjuan"

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63Publications

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Validation and noninvasive kinetic modeling of [C]UCB-J PET imaging in mice.

J Cereb Blood Flow Metab 2019 Jul 15:271678X19864081. Epub 2019 Jul 15.

1 Molecular Imaging Center Antwerp (MICA), University of Antwerp, Wilrijk, Belgium.

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http://dx.doi.org/10.1177/0271678X19864081DOI Listing
July 2019

Unravelling and Exploiting Astrocyte Dysfunction in Huntington's Disease.

Trends Neurosci 2017 07 31;40(7):422-437. Epub 2017 May 31.

Exzellenzcluster NeuroCure & Abt. Experimentelle Neurologie, Charité - Universitätsmedizin Berlin, Robert-Koch-Platz 4, D-10115 Berlin, Germany.

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http://dx.doi.org/10.1016/j.tins.2017.05.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5706770PMC
July 2017

Support communities involved in disease studies.

Nature 2016 Mar;531(7593):141

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http://dx.doi.org/10.1038/531141aDOI Listing
March 2016

Therapeutic Strategies for Huntington's Disease.

Curr Top Behav Neurosci 2015 ;22:161-201

CHDI Management/CHDI Foundation Inc., Los Angeles, CA, USA.

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http://dx.doi.org/10.1007/7854_2013_250DOI Listing
September 2015

Targeting ATM ameliorates mutant Huntingtin toxicity in cell and animal models of Huntington's disease.

Sci Transl Med 2014 Dec;6(268):268ra178

Center for Neurobehavioral Genetics, Semel Institute for Neuroscience & Human Behavior, University of California, Los Angeles (UCLA), Los Angeles, CA 90095, USA. Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA. UCLA Brain Research Institute, Los Angeles, CA 90095, USA.

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http://dx.doi.org/10.1126/scitranslmed.3010523DOI Listing
December 2014

Mind the gap: models in multiple species needed for therapeutic development in Huntington's disease.

Mov Disord 2014 Sep 22;29(11):1397-403. Epub 2014 Aug 22.

CHDI Management/CHDI Foundation, Princeton, New Jersey, USA.

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http://dx.doi.org/10.1002/mds.26008DOI Listing
September 2014

Foundation-directed therapeutic development in Huntington's disease.

J Med Chem 2014 Jul 4;57(13):5479-88. Epub 2014 Feb 4.

CHDI Management, Inc., Advisors to CHDI Foundation, Inc., 6080 Center Drive, Los Angeles, California 90045, United States.

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http://dx.doi.org/10.1021/jm4009295DOI Listing
July 2014

Advances in huntington disease drug discovery: novel approaches to model disease phenotypes.

J Biomol Screen 2014 Feb 6;19(2):191-204. Epub 2013 Nov 6.

1CHDI Management/CHDI Foundation, Princeton, NJ, and Los Angeles, CA, USA.

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http://dx.doi.org/10.1177/1087057113510320DOI Listing
February 2014

Metabolism and pharmacokinetics of JM6 in mice: JM6 is not a prodrug for Ro-61-8048.

Drug Metab Dispos 2012 Dec 31;40(12):2297-306. Epub 2012 Aug 31.

CHDI Management/CHDI Foundation, 300 Alexander Park, Suite 110, Princeton, NJ 08540, USA.

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http://dx.doi.org/10.1124/dmd.112.046532DOI Listing
December 2012

Pharmacokinetics of memantine in rats and mice.

PLoS Curr 2011 Dec 15;3:RRN1291. Epub 2011 Dec 15.

Director, DMPK, CHDI Management/CHDI Foundation, Princeton, NJ; Director of In Vivo Biology, CHDI Foundation Inc; Director, PreClinical Research, CHDI Foundation, Inc; Pharmacokinetic consultant for the CHDI Foundation, Holland NY; CHDI Foundation, Inc.; VP, Chemistry CHDI Foundation/ CHDI Management Inc. Los Angeles CA; VP Translational Biology, CHDI Management/CHDI Foundation Inc., Los Angeles (USA) and CSO - Drug Discovery & Development, CHDI Foundation / CHDI Management.

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http://dx.doi.org/10.1371/currents.RRN1291DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3269340PMC
December 2011

The importance of integrating basic and clinical research toward the development of new therapies for Huntington disease.

J Clin Invest 2011 Feb 1;121(2):476-83. Epub 2011 Feb 1.

CHDI Management Inc./CHDI Foundation Inc., 6080 Center Drive, Suite 100, Los Angeles, California 90046, USA.

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http://dx.doi.org/10.1172/JCI45364DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3026740PMC
February 2011

Glial progenitor cell transplantation and the generation of chimeric animal models with human brain cells: implications for novel therapeutics.

Expert Opin Ther Pat 2009 Dec;19(12):1639-46

Biology, CHDI Foundation, Inc., Suite 100, Los Angeles, CA 90045, USA.

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http://dx.doi.org/10.1517/13543770903443105DOI Listing
December 2009

Behavioral and neurochemical alterations in mice deficient in anaplastic lymphoma kinase suggest therapeutic potential for psychiatric indications.

Neuropsychopharmacology 2008 Feb 9;33(3):685-700. Epub 2007 May 9.

Department of Molecular and Cellular Neuroscience, Merck Sharp and Dohme, The Neuroscience Research Centre, Essex, UK.

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http://dx.doi.org/10.1038/sj.npp.1301446DOI Listing
February 2008

Evidence for an enhancement of excitatory transmission in adult CNS by Wnt signaling pathway modulation.

Mol Cell Neurosci 2007 Aug 14;35(4):513-24. Epub 2007 Mar 14.

The Neuroscience Research Centre, Merck Sharp and Dohme, Terlings Park, Harlow Essex CM20 2QR, UK.

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http://dx.doi.org/10.1016/j.mcn.2007.03.004DOI Listing
August 2007

Identification of proteomic changes during differentiation of adult mouse subventricular zone progenitor cells.

Stem Cells Dev 2007 Feb;16(1):143-65

Merck Sharp & Dohme Research Laboratories, The Neuroscience Research Centre, Terlings Park, Harlow, Essex, CM20 2QR, United Kingdom.

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http://dx.doi.org/10.1089/scd.2006.00100DOI Listing
February 2007

A rapid method for the quantification of mouse hippocampal neurogenesis in vivo by flow cytometry. Validation with conventional and enhanced immunohistochemical methods.

J Neurosci Methods 2006 Oct 31;157(1):54-63. Epub 2006 Jul 31.

Department of Molecular and Cellular Neuroscience, Merck, Sharp and Dohme Neuroscience Research Centre, Terlings Park, Eastwick Road, Harlow, Essex, CM20 2QR, UK.

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http://dx.doi.org/10.1016/j.jneumeth.2006.03.026DOI Listing
October 2006

Proteomic analysis identifies alterations in cellular morphology and cell death pathways in mouse brain after chronic corticosterone treatment.

Brain Res 2006 Aug 23;1102(1):12-26. Epub 2006 Jun 23.

Department of Molecular and Cellular Neuroscience, Merck Sharp and Dohme Research Laboratories, The Neuroscience Research Centre, Terlings Park, Harlow, Essex, UK.

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http://dx.doi.org/10.1016/j.brainres.2006.04.112DOI Listing
August 2006

Molecular characterization of adult mouse subventricular zone progenitor cells during the onset of differentiation.

Eur J Neurosci 2006 Aug;24(3):661-75

Molecular and Cellular Neuroscience Department, Merck Sharp & Dohme, The Neuroscience Research Centre, Terlings Park, Harlow, Essex CM20 2QR, UK.

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http://dx.doi.org/10.1111/j.1460-9568.2006.04912.xDOI Listing
August 2006

Identification of differentiating neural progenitor cell markers using shotgun isobaric tagging mass spectrometry.

Stem Cells Dev 2006 Jun;15(3):461-70

Merck Sharp & Dohme Research Laboratories, The Neuroscience Research Centre, Terlings Park, Harlow, Essex, UK.

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http://dx.doi.org/10.1089/scd.2006.15.461DOI Listing
June 2006

Induction of ectopic olfactory structures and bone morphogenetic protein inhibition by Rossy, a group XII secreted phospholipase A2.

Mol Cell Biol 2005 May;25(9):3608-19

Laboratory of Vertebrate Embryology, Rockefeller University, 1230 York Avenue, New York, NY 10021, USA.

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http://dx.doi.org/10.1128/MCB.25.9.3608-3619.2005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1084286PMC
May 2005

Molecular signature of human embryonic stem cells and its comparison with the mouse.

Dev Biol 2003 Aug;260(2):404-13

Laboratory of Vertebrate Molecular Embryology, The Rockefeller University, 1230, York Avenue, New York, NY 10021, USA.

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http://dx.doi.org/10.1016/s0012-1606(03)00256-2DOI Listing
August 2003

Cell fate specification and competence by Coco, a maternal BMP, TGFbeta and Wnt inhibitor.

Development 2003 Apr;130(7):1381-9

The Laboratory of Vertebrate Embryology, The Rockefeller University, New York, NY 10021, USA.

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http://dx.doi.org/10.1242/dev.00344DOI Listing
April 2003

Fluorescent labeling of endothelial cells allows in vivo, continuous characterization of the vascular development of Xenopus laevis.

Dev Biol 2003 Feb;254(1):50-67

Laboratory of Molecular Embryology, Rockefeller University, 1230 York Avenue, New York, NY 10021, USA.

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http://dx.doi.org/10.1016/s0012-1606(02)00029-5DOI Listing
February 2003

Gene profiling during neural induction in Xenopus laevis: regulation of BMP signaling by post-transcriptional mechanisms and TAB3, a novel TAK1-binding protein.

Development 2002 Dec;129(23):5529-40

The Laboratory of Vertebrate Embryology, The Rockefeller University, New York, NY, USA.

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http://dx.doi.org/10.1242/dev.00097DOI Listing
December 2002

The latent-TGFbeta-binding-protein-1 (LTBP-1) is expressed in the organizer and regulates nodal and activin signaling.

Dev Biol 2002 Aug;248(1):118-27

Laboratory of Molecular Embryology, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA.

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http://dx.doi.org/10.1006/dbio.2002.0716DOI Listing
August 2002

Neural induction, the default model and embryonic stem cells.

Nat Rev Neurosci 2002 Apr;3(4):271-80

Laboratory of Molecular Vertebrate Embryology, The Rockefeller University, New York, New York 10021, USA.

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http://dx.doi.org/10.1038/nrn786DOI Listing
April 2002