Publications by authors named "Ignacio I Wistuba"

100Publications

Molecular differences across invasive lung adenocarcinoma morphological subgroups.

Transl Lung Cancer Res 2020 Aug;9(4):1029-1040

Quantitative Biomedical Research Center, Department of Population and Data Sciences, University of Texas Southwestern Medical Center, Dallas, TX, USA.

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http://dx.doi.org/10.21037/tlcr-19-321DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7481608PMC
August 2020

Transition from a Standard to a Hybrid On-Site and Remote Anatomic Pathology Training Model During the COVID-19 Pandemic.

Arch Pathol Lab Med 2020 Sep 16. Epub 2020 Sep 16.

Departments of Pathology (Chin, Kwon, Gan, Ramalingam, Prieto, Aung) and Translational Molecular Pathology (Wistuba), at The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

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http://dx.doi.org/10.5858/arpa.2020-0467-SADOI Listing
September 2020

Collagen promotes anti-PD-1/PD-L1 resistance in cancer through LAIR1-dependent CD8 T cell exhaustion.

Nat Commun 2020 09 9;11(1):4520. Epub 2020 Sep 9.

Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.

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http://dx.doi.org/10.1038/s41467-020-18298-8DOI Listing
September 2020

Female Gender Predicts Augmented Immune Infiltration in Lung Adenocarcinoma.

Clin Lung Cancer 2020 Jun 14. Epub 2020 Jun 14.

Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX; Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX.

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http://dx.doi.org/10.1016/j.cllc.2020.06.003DOI Listing
June 2020

A Phase II Trial of Alisertib (MLN8237) in Salvage Malignant Mesothelioma.

Oncologist 2020 Jul 1. Epub 2020 Jul 1.

Department of Thoracic/Head & Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

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http://dx.doi.org/10.1634/theoncologist.2020-0610DOI Listing
July 2020

An in vivo functional genomics screen of nuclear receptors and their co-regulators identifies FOXA1 as an essential gene in lung tumorigenesis.

Neoplasia 2020 Aug 13;22(8):294-310. Epub 2020 May 13.

Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, TX, USA; Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX, USA; Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA; Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neo.2020.04.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7281309PMC
August 2020

LKB1/STK11 Expression in Lung Adenocarcinoma and Associations With Patterns of Recurrence.

Ann Thorac Surg 2020 Oct 19;110(4):1131-1138. Epub 2020 May 19.

Department of Thoracic and Cardiovascular Surgery, University of Texas MD Anderson Cancer Center, Houston, Texas. Electronic address:

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http://dx.doi.org/10.1016/j.athoracsur.2020.03.114DOI Listing
October 2020

T-Cell Repertoire in Combination with T-Cell Density Predicts Clinical Outcomes in Patients with Merkel Cell Carcinoma.

J Invest Dermatol 2020 Apr 15. Epub 2020 Apr 15.

Department of Pathology and Laboratory Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA; Department of Translational and Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jid.2020.02.031DOI Listing
April 2020

Computational Staining of Pathology Images to Study the Tumor Microenvironment in Lung Cancer.

Cancer Res 2020 May 8;80(10):2056-2066. Epub 2020 Jan 8.

Quantitative Biomedical Research Center, Department of Population and Data Sciences, University of Texas Southwestern Medical Center, Dallas, Texas.

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http://dx.doi.org/10.1158/0008-5472.CAN-19-1629DOI Listing
May 2020

RUVBL1/RUVBL2 ATPase Activity Drives PAQosome Maturation, DNA Replication and Radioresistance in Lung Cancer.

Cell Chem Biol 2020 01 26;27(1):105-121.e14. Epub 2019 Dec 26.

Eugene McDermott Center for Human Growth and Development, UT Southwestern Medical Center, Dallas, TX 75390, USA; Department of Pharmacology, UT Southwestern Medical Center, Dallas, TX 75390, USA; Harold C. Simmons Comprehensive Cancer Center, UT Southwestern Medical Center, Dallas, TX 75390, USA. Electronic address:

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http://dx.doi.org/10.1016/j.chembiol.2019.12.005DOI Listing
January 2020

From clinical specimens to human cancer preclinical models-a journey the NCI-cell line database-25 years later.

J Cell Biochem 2019 Dec 5. Epub 2019 Dec 5.

Nancy B. and Jake L. Hamon Center for Therapeutic Oncology Research, UT Southwestern Medical Center, Dallas, Texas.

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http://dx.doi.org/10.1002/jcb.29564DOI Listing
December 2019

ConvPath: A software tool for lung adenocarcinoma digital pathological image analysis aided by a convolutional neural network.

EBioMedicine 2019 Dec 22;50:103-110. Epub 2019 Nov 22.

Quantitative Biomedical Research Center, Department of Population and Data Sciences, University of Texas Southwestern Medical Center, Dallas, TX; Department of Bioinformatics, University of Texas Southwestern Medical Center, Dallas, TX; Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX. Electronic address:

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http://dx.doi.org/10.1016/j.ebiom.2019.10.033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6921240PMC
December 2019

Multiplex Immunofluorescence Assays.

Methods Mol Biol 2020 ;2055:467-495

Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

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http://dx.doi.org/10.1007/978-1-4939-9773-2_22DOI Listing
January 2020

Non-invasive genotyping of metastatic colorectal cancer using circulating cell free DNA.

Cancer Genet 2019 09 12;237:82-89. Epub 2019 Jun 12.

Department of Translational Molecular Pathology, Division of Pathology and Laboratory Medicine, The University of Texas M.D. Anderson Cancer Center, 6565 MD Anderson Blvd., Houston, TX 77030, United States; Department of Hematopathology, The University of Texas M.D. Anderson Cancer Center, Houston, TX, United States. Electronic address:

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http://dx.doi.org/10.1016/j.cancergen.2019.06.004DOI Listing
September 2019

Development and Application of Duplex Sequencing Strategy for Cell-Free DNA-Based Longitudinal Monitoring of Stage IV Colorectal Cancer.

J Mol Diagn 2019 11 8;21(6):994-1009. Epub 2019 Aug 8.

Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas; Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, Texas. Electronic address:

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http://dx.doi.org/10.1016/j.jmoldx.2019.06.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6854476PMC
November 2019

Removal of N-Linked Glycosylation Enhances PD-L1 Detection and Predicts Anti-PD-1/PD-L1 Therapeutic Efficacy.

Cancer Cell 2019 08 18;36(2):168-178.e4. Epub 2019 Jul 18.

Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA; Graduate Institute of Biomedical Sciences and Center for Molecular Medicine, China Medical University, Taichung 404, Taiwan; Department of Biotechnology, Asia University, Taichung 413, Taiwan; Graduate School of Biomedical Sciences, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2019.06.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6793936PMC
August 2019

Sphingosine Kinase 1 Signaling Promotes Metastasis of Triple-Negative Breast Cancer.

Cancer Res 2019 08 25;79(16):4211-4226. Epub 2019 Jun 25.

Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.

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http://dx.doi.org/10.1158/0008-5472.CAN-18-3803DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6697620PMC
August 2019

Tumor cellular proliferation is associated with enhanced immune checkpoint expression in stage I non-small cell lung cancer.

J Thorac Cardiovasc Surg 2019 09 17;158(3):911-919.e6. Epub 2019 May 17.

Department of Thoracic and Cardiovascular Surgery, University of Texas MD Anderson Cancer Center, Houston, Tex. Electronic address:

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http://dx.doi.org/10.1016/j.jtcvs.2019.04.084DOI Listing
September 2019

Genomic landscape of allelic imbalance in premalignant atypical adenomatous hyperplasias of the lung.

EBioMedicine 2019 Apr 21;42:296-303. Epub 2019 Mar 21.

Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA; The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences, Houston, TX, USA; Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ebiom.2019.03.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6491940PMC
April 2019

Rational "Error Elimination" Approach to Evaluating Molecular Barcoded Next-Generation Sequencing Data Identifies Low-Frequency Mutations in Hematologic Malignancies.

J Mol Diagn 2019 05 20;21(3):471-482. Epub 2019 Feb 20.

Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas; Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, Texas. Electronic address:

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http://dx.doi.org/10.1016/j.jmoldx.2019.01.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6521894PMC
May 2019

Centrifuged supernatants from FNA provide a liquid biopsy option for clinical next-generation sequencing of thyroid nodules.

Cancer Cytopathol 2019 03 8;127(3):146-160. Epub 2019 Jan 8.

Department of Pathology, Division of Pathology and Laboratory Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas.

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http://dx.doi.org/10.1002/cncy.22098DOI Listing
March 2019

Transcriptome Deconvolution of Heterogeneous Tumor Samples with Immune Infiltration.

iScience 2018 Nov 2;9:451-460. Epub 2018 Nov 2.

Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA. Electronic address:

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http://dx.doi.org/10.1016/j.isci.2018.10.028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6249353PMC
November 2018

Reply to Oegema et al.: CFI-400945 and Polo-like kinase 4 inhibition.

Proc Natl Acad Sci U S A 2018 11 30;115(46):E10810-E10811. Epub 2018 Oct 30.

Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030.

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http://dx.doi.org/10.1073/pnas.1813967115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6243257PMC
November 2018

Randomized, Double-Blind, Phase II Study of Temozolomide in Combination With Either Veliparib or Placebo in Patients With Relapsed-Sensitive or Refractory Small-Cell Lung Cancer.

J Clin Oncol 2018 08 15;36(23):2386-2394. Epub 2018 Jun 15.

M. Catherine Pietanza, Lee M. Krug, Mark G. Kris, and Charles M. Rudin, Memorial Sloan-Kettering Cancer Center and Weill Cornell Medical College; Kaitlin M. Woo, Yevgeniva Bensman, Brenda Hurtado, and Martin Fleisher, Memorial Sloan Kettering Cancer Center, New York, NY; Saiama N. Waqar, Washington University School of Medicine in St. Louis, St Louis, MO; Afshin Dowlati, Case Western Reserve University and University Hospitals Seidman Cancer Center, Cleveland, OH; Christine L. Hann, Johns Hopkins University, Baltimore; Alice Chen, National Institutes of Health, Bethesda, MD; Alberto Chiappori, H. Lee Moffitt Cancer Center, Tampa, FL; Taofeek K. Owonikoko, Emory University, Atlanta, GA; and Robert J. Cardnell, Junya Fujimoto, Lihong Long, Lixia Diao, Jing Wang, Patricia de Groot, Erik P. Sulman, Ignacio I. Wistuba, John V. Heymach, and Lauren Averett Byers, The University of Texas MD Anderson Cancer Center, Houston, TX.

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http://dx.doi.org/10.1200/JCO.2018.77.7672DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6085179PMC
August 2018

Mutations and PD-1 Inhibitor Resistance in -Mutant Lung Adenocarcinoma.

Cancer Discov 2018 07 17;8(7):822-835. Epub 2018 May 17.

Department of Thoracic and Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.

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http://dx.doi.org/10.1158/2159-8290.CD-18-0099DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6030433PMC
July 2018

Major pathologic response and RAD51 predict survival in lung cancer patients receiving neoadjuvant chemotherapy.

Cancer Med 2018 06 19;7(6):2405-2414. Epub 2018 Apr 19.

Department of Thoracic and Cardiovascular Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas.

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http://dx.doi.org/10.1002/cam4.1505DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6010873PMC
June 2018

Immunohistochemical and Image Analysis-Based Study Shows That Several Immune Checkpoints are Co-expressed in Non-Small Cell Lung Carcinoma Tumors.

J Thorac Oncol 2018 06 8;13(6):779-791. Epub 2018 Mar 8.

Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas; Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas. Electronic address:

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http://dx.doi.org/10.1016/j.jtho.2018.03.002DOI Listing
June 2018