Ignacio Brouard

Ignacio Brouard

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Ignacio Brouard

Ignacio Brouard

Publications by authors named "Ignacio Brouard"

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6'-Benzyloxy-4-bromo-2'-hydroxychalcone is cytotoxic against human leukaemia cells and induces caspase-8- and reactive oxygen species-dependent apoptosis.

Chem Biol Interact 2019 Jan 19;298:137-145. Epub 2018 Dec 19.

Departamento de Bioquímica y Biología Molecular, Unidad Asociada al Consejo Superior de Investigaciones Científicas (CSIC), Instituto Universitario de Investigaciones Biomédicas y Sanitarias (IUIBS), Universidad de las Palmas de Gran Canaria, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.cbi.2018.12.010DOI Listing
January 2019

Centaurea microcarpa Coss. & Dur. (Asteraceae) extracts: New cyanogenic glucoside and other constituents.

Nat Prod Res 2018 Nov 16:1-7. Epub 2018 Nov 16.

a Unité de recherche Valorisation des Ressources Naturelles, Molécules Bioactives et Analyses Physicochimiques et Biologiques (VARENBIOMOL) , Université des Frères Mentouri Constantine , Constantine , Algérie.

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https://www.tandfonline.com/doi/full/10.1080/14786419.2018.1
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http://dx.doi.org/10.1080/14786419.2018.1517343DOI Listing
November 2018

3'-Hydroxy-3,4'-dimethoxyflavone-induced cell death in human leukaemia cells is dependent on caspases and reactive oxygen species and attenuated by the inhibition of JNK/SAPK.

Chem Biol Interact 2018 May 6;288:1-11. Epub 2018 Apr 6.

Departamento de Bioquímica y Biología Molecular, Unidad Asociada al Consejo Superior de Investigaciones Científicas (CSIC), Instituto Universitario de Investigaciones Biomédicas y Sanitarias, Universidad de las Palmas de Gran Canaria, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.cbi.2018.04.006DOI Listing
May 2018

3'-Hydroxy-3,4'-dimethoxyflavone blocks tubulin polymerization and is a potent apoptotic inducer in human SK-MEL-1 melanoma cells.

Bioorg Med Chem 2017 11 3;25(21):6060-6070. Epub 2017 Oct 3.

Departamento de Bioquímica y Biología Molecular, Unidad Asociada al Consejo Superior de Investigaciones Científicas (CSIC), Instituto Universitario de Investigaciones Biomédicas y Sanitarias, Universidad de las Palmas de Gran Canaria, Paseo Blas Cabrera Felipe s/n, 35016 Las Palmas de Gran Canaria, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.bmc.2017.09.043DOI Listing
November 2017

Antiproliferative activity and apoptosis induction by 3',4'-dibenzyloxyflavonol on human leukemia cells.

Chem Biol Interact 2017 Apr 22;268:13-23. Epub 2017 Feb 22.

Departamento de Bioquímica y Biología Molecular, Unidad Asociada al Consejo Superior de Investigaciones Científicas (CSIC), Instituto Universitario de Investigaciones Biomédicas y Sanitarias, Universidad de las Palmas de Gran Canaria, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.cbi.2017.02.010DOI Listing
April 2017

Sesquiterpenoids Isolated from Two Species of the Asteriscus Alliance.

J Nat Prod 2016 05 4;79(5):1292-7. Epub 2016 May 4.

Instituto de Productos Naturales y Agrobiología-Consejo Superior de Investigaciones Científicas (CSIC) , Avenida Astrofísico Francisco Sánchez 3, 38206 La Laguna, Tenerife, Spain.

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http://dx.doi.org/10.1021/acs.jnatprod.5b01013DOI Listing
May 2016

New quinoline alkaloid from Ruta graveolens aerial parts and evaluation of the antifertility activity.

Nat Prod Res 2014 4;28(17):1335-42. Epub 2014 Apr 4.

a Chemistry of Tannins Department , National Research Centre , Dokki, Cairo , Egypt.

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http://www.tandfonline.com/doi/abs/10.1080/14786419.2014.903
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http://dx.doi.org/10.1080/14786419.2014.903395DOI Listing
December 2014

Synthesis and effects on cell viability of flavonols and 3-methyl ether derivatives on human leukemia cells.

Eur J Med Chem 2014 Sep 4;84:30-41. Epub 2014 Jul 4.

Departamento de Bioquímica y Biología Molecular, Unidad Asociada al Consejo Superior de Investigaciones Científicas (CSIC), Instituto Canario de Investigación del Cáncer, Universidad de Las Palmas de Gran Canaria, Plaza Dr. Pasteur s/n, 35016 Las Palmas de Gran Canaria, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2014.07.010DOI Listing
September 2014

A chemotaxonomic study of endemic species of genus Tanacetum from the Canary Islands.

Phytochemistry 2013 Aug 25;92:87-104. Epub 2013 May 25.

Departamento de Química, Unidad Asociada al CSIC, Universidad de Las Palmas de Gran Canaria, Campus de Tafira, 35017 Las Palmas de Gran Canaria, Canary Islands, Spain.

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http://dx.doi.org/10.1016/j.phytochem.2013.04.015DOI Listing
August 2013

Multicomponent ligation of steroids: creating diversity at the linkage moiety of bis-spirostanic conjugates by Ugi reactions.

ACS Comb Sci 2013 Jun 7;15(6):320-30. Epub 2013 May 7.

Center for Natural Products Study, Faculty of Chemistry, University of Havana, Zapata y G, 10400, La Habana, Cuba.

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http://dx.doi.org/10.1021/co400028eDOI Listing
June 2013

Secondary metabolites from two species of Tolpis and their biological activities.

Molecules 2012 Nov 1;17(11):12895-909. Epub 2012 Nov 1.

Departamento de Química, Unidad Asociada al CSIC, Universidad de Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, Spain.

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http://dx.doi.org/10.3390/molecules171112895DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268065PMC
November 2012

Effect of C-ring modifications on the cytotoxicity of spirostan saponins and related glycosides.

Bioorg Med Chem 2012 Jul 17;20(14):4522-31. Epub 2012 May 17.

Institute of Pharmacy and Food, University of Havana, San Lázaro y L, 10400 La Habana, Cuba.

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http://dx.doi.org/10.1016/j.bmc.2012.05.018DOI Listing
July 2012

Multicomponent synthesis of Ugi-type ceramide analogues and neoglycolipids from lipidic isocyanides.

J Org Chem 2012 May 10;77(10):4660-70. Epub 2012 May 10.

Institute of Pharmacy and Food, University of Havana, San Lázaro y L, 10400, La Habana, Cuba.

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http://dx.doi.org/10.1021/jo300462mDOI Listing
May 2012

A new flavonoid and other constituents from Centaurea nicaeensis All. var. walliana M.

Nat Prod Res 2012 4;26(3):203-8. Epub 2011 Aug 4.

Laboratoire de Phytochimie et Analyses Physico-Chimiques et Biologiques, Université Mentouri, Route de Aïn El Bey, 25 000 Constantine, Algeria.

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http://dx.doi.org/10.1080/14786419.2010.534995DOI Listing
April 2012

New insights into the structure-cytotoxicity relationship of spirostan saponins and related glycosides.

Bioorg Med Chem 2012 Apr 15;20(8):2690-700. Epub 2012 Feb 15.

Instituto de Productos Naturales y Agrobiología-CSIC, Av. Astrofísico Francisco Sánchez 3, 38206 La Laguna, Tenerife, Spain.

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http://dx.doi.org/10.1016/j.bmc.2012.02.026DOI Listing
April 2012

Secondary metabolites from two species of Pulicaria and their cytotoxic activity.

Chem Biodivers 2011 Nov;8(11):2080-9

Departamento de Química, Universidad de Las Palmas de Gran Canaria, Unidad Asociada al CSIC, Campus de Tafira, SP, Las Palmas de Gran Canaria.

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http://dx.doi.org/10.1002/cbdv.201000324DOI Listing
November 2011

Chemotaxonomy of Gonospermum and related genera.

Phytochemistry 2010 Apr 22;71(5-6):627-34. Epub 2010 Jan 22.

Departamento de Química, Universidad de Las Palmas de Gran Canaria, Campus de Tafira, 35017 Las Palmas de Gran Canaria, Canary Islands, Spain.

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http://dx.doi.org/10.1016/j.phytochem.2009.12.013DOI Listing
April 2010

Chemical constituents of Tolpis species.

Fitoterapia 2009 Oct 11;80(7):437-41. Epub 2009 Jun 11.

Departamento de Química, Universidad de Las Palmas de Gran Canaria, Campus de Tafira, 35017, Las Palmas de Gran Canaria, Gran Canaria, Canary Islands, Spain.

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http://dx.doi.org/10.1016/j.fitote.2009.06.001DOI Listing
October 2009

Sesquiterpene lactones from Gonospermum gomerae and G. fruticosum and their cytotoxic activities.

J Nat Prod 2008 Dec;71(12):2015-20

Departamento de Química, Universidad de Las Palmas de Gran Canaria, Campus de Tafira, 35017 Las Palmas de Gran Canaria, Canary Islands, Spain.

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http://dx.doi.org/10.1021/np800474vDOI Listing
December 2008

Synthesis of novel spirostanic saponins and their cytotoxic activity.

Bioorg Med Chem 2008 Feb 4;16(4):2063-76. Epub 2007 Nov 4.

Instituto de Productos Naturales y Agrobiología-C.S.I.C., Antonio González, Av. Astrofísico F. Sánchez 3, 38206 La Laguna, Tenerife, Spain.

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https://linkinghub.elsevier.com/retrieve/pii/S09680896070095
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http://dx.doi.org/10.1016/j.bmc.2007.10.089DOI Listing
February 2008

A new ceramide from Suillus luteus and its cytotoxic activity against human melanoma cells.

Chem Biodivers 2008 Jan;5(1):120-5

Instituto de Productos Naturales y Agrobiología, CSIC, Instituto Universitario de Bio-Orgánica Antonio González, Av. Astrofísico F. Sánchez 3, E-38206 La Laguna, Tenerife.

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http://dx.doi.org/10.1002/cbdv.200890002DOI Listing
January 2008

A new lupene triterpenetriol and anticholinesterase activity of Salvia sclareoides.

Fitoterapia 2007 Dec 10;78(7-8):474-81. Epub 2007 May 10.

Centro de Química e Bioquímica, Departamento de Química e Bioquímica, Faculdade de Ciências da Universidade de Lisboa, Campo Grande, 1749-016 Lisboa, Portugal.

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http://dx.doi.org/10.1016/j.fitote.2007.02.013DOI Listing
December 2007

Isolation, structure elucidation, total synthesis, and evaluation of new natural and synthetic ceramides on human SK-MEL-1 melanoma cells.

J Med Chem 2006 Sep;49(19):5830-9

Instituto de Productos Naturales y Agrobiología, C.S.I.C., Instituto Universitario de Bio-Organica Antonio Gonzalez, Avda. Astrofísico F. Sanchez 3, 38206 La Laguna, Tenerife, Spain.

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http://dx.doi.org/10.1021/jm0605334DOI Listing
September 2006

Design, synthesis, and biological evaluation of potent discodermolide fluorescent and photoaffinity molecular probes.

Org Lett 2005 Nov;7(23):5199-202

Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.

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http://dx.doi.org/10.1021/ol0520166DOI Listing
November 2005

Toward understanding how the lactone moiety of discodermolide affects activity.

J Am Chem Soc 2005 May;127(18):6532-3

Kosan Biosciences, Inc., 3832 Bay Center Place, Hayward, CA 94545, USA.

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http://dx.doi.org/10.1021/ja051185iDOI Listing
May 2005

Design, synthesis, and evaluation of analogues of (+)-14-normethyldiscodermolide.

Org Lett 2005 Jan;7(2):315-8

Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.

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http://dx.doi.org/10.1021/ol0476873DOI Listing
January 2005

Enantioselective synthesis and biological activity of (3S,4R)- and (3S,4S)-3-hydroxy-4-hydroxymethyl- 4-butanolides in relation to PGE2.

J Med Chem 2004 Jan;47(2):292-5

Instituto Universitario de Bio-Orgánica Antonio González-Instituto de Productos Naturales y Agrobiología-CSIC, Avenida Astrofísico F. Sánchez 3, 38206 La Laguna, Tenerife, Canary Islands, Spain.

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http://dx.doi.org/10.1021/jm034216yDOI Listing
January 2004

A practical improvement, enhancing the large-scale synthesis of (+)-discodermolide: a third-generation approach.

Org Lett 2003 Nov;5(23):4405-8

Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.

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http://dx.doi.org/10.1021/ol035697iDOI Listing
November 2003