Publications by authors named "Ie-Ming Shih"

100Publications

Proteome-wide Tyrosine Phosphorylation Analysis Reveals Dysregulated Signaling Pathways in Ovarian Tumors.

Mol Cell Proteomics 2019 Mar 22;18(3):448-460. Epub 2020 Sep 22.

Department of Pharmacology & Molecular Sciences, Johns Hopkins School of Medicine, Baltimore, Maryland 21205;. Electronic address:

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March 2019

Epigenomic Reprogramming toward Mesenchymal-Epithelial Transition in Ovarian-Cancer-Associated Mesenchymal Stem Cells Drives Metastasis.

Cell Rep 2020 Dec;33(10):108473

Division of Hematology/Oncology, Department of Medicine, Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA, USA; Division of Gynecologic Oncology, Department of Obstetrics, Gynecology, and Reproductive Sciences, Magee Women's Research Institute, University of Pittsburgh, Pittsburgh, PA, USA. Electronic address:

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December 2020

Pathology and Pathogenesis of Adenomyosis.

Semin Reprod Med 2020 May 20;38(2-03):108-118. Epub 2020 Oct 20.

Department of Gynecology and Obstetrics, Johns Hopkins University School of Medicine, Baltimore, Maryland.

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May 2020

Genome-wide mutation analysis in precancerous lesions of endometrial carcinoma.

J Pathol 2021 Jan 13;253(1):119-128. Epub 2020 Nov 13.

Department of Pathology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, PR China.

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January 2021

The Origin of Ovarian Cancer Species and Precancerous Landscape.

Am J Pathol 2021 Jan 1;191(1):26-39. Epub 2020 Oct 1.

Department of Gynecology and Obstetrics, Johns Hopkins University School of Medicine, Baltimore, Maryland; Pathobiology Graduate Program, Johns Hopkins University School of Medicine, Baltimore, Maryland.

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January 2021

Urothelial Carcinomas With Trophoblastic Differentiation, Including Choriocarcinoma: Clinicopathologic Series of 16 Cases.

Am J Surg Pathol 2020 10;44(10):1322-1330

*Robert J Tomsich Pathology and Laboratory Medicine Institute, Cleveland Clinic, Cleveland, OH †Boca Raton Regional Hospital/Florida Atlantic University College of Medicine, Boca Raton, FL ‡Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA §Department of Gynecology and Obstetrics, Johns Hopkins Medical Institutions, Baltimore, MD.

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October 2020

Methylomic Landscapes of Ovarian Cancer Precursor Lesions.

Clin Cancer Res 2020 Dec 17;26(23):6310-6320. Epub 2020 Aug 17.

Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland.

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December 2020

NAC1 attenuates BCL6 negative autoregulation and functions as a BCL6 coactivator of FOXQ1 transcription in cancer cells.

Aging (Albany NY) 2020 05 14;12(10):9275-9291. Epub 2020 May 14.

Department of Toxicology and Cancer Biology, College of Medicine, Markey Cancer Center, University of Kentucky, Lexington, KY 40536, USA.

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May 2020

Epithelial Cells in Endometriosis and Adenomyosis Upregulate STING Expression.

Reprod Sci 2020 06 6;27(6):1276-1284. Epub 2020 Jan 6.

Department of Gynecology and Obstetrics, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

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June 2020

Not All Peritoneal Implants Are Created Equal.

Gynecol Oncol 2020 01;156(1):1-2

Department of Gynecology and Obstetrics, Johns Hopkins University School of Medicine, Baltimore, Maryland.

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January 2020

-mutated ovarian serous borderline tumors are at relatively low risk for progression to serous carcinoma.

Oncotarget 2019 Dec 3;10(64):6870-6878. Epub 2019 Dec 3.

Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.

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December 2019

Oncogenic BRAF and KRAS mutations in endosalpingiosis.

J Pathol 2020 02 29;250(2):148-158. Epub 2019 Nov 29.

Department of Gynecology and Obstetrics, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

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February 2020

Spleen tyrosine kinase activity regulates epidermal growth factor receptor signaling pathway in ovarian cancer.

EBioMedicine 2019 Sep 3;47:184-194. Epub 2019 Sep 3.

Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins Medical Institutions, Baltimore, MD 21231, United States of America; Department of Gynecology and Obstetrics, Johns Hopkins Medical Institutions, Baltimore, MD 21287, United States of America. Electronic address:

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September 2019

The Origin and Pathogenesis of Endometriosis.

Annu Rev Pathol 2020 01 3;15:71-95. Epub 2019 Sep 3.

Pathobiology Graduate Program, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA; email:

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January 2020

Cytomorphologic and molecular analyses of fallopian tube fimbrial brushings for diagnosis of serous tubal intraepithelial carcinoma.

Cancer Cytopathol 2019 03 12;127(3):192-201. Epub 2019 Mar 12.

Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, Maryland.

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March 2019

Follicular fluid has more to offer: Insulin-like growth factor axis on ovarian carcinogenesis.

EBioMedicine 2019 Mar 21;41:30-31. Epub 2019 Feb 21.

Department of Gynecology and Obstetrics, Johns Hopkins Medical Institutions, Baltimore, MD 21209, United States of America. Electronic address:

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March 2019

Molecular Classification and Emerging Targeted Therapy in Endometrial Cancer.

Int J Gynecol Pathol 2020 Jan;39(1):26-35

TeLinde Gynecologic Pathology Research Program, Department of Gynecology and Obstetrics (T.T.Y., T.L.W., I.M.S., S.G.) Kelly Gynecologic Oncology Service, Department of Gynecology and Obstetrics (T.T.Y., A.N.F., S.G.) Department of Pathology (T.L.W.) Department of Oncology (S.G.), Johns Hopkins University School of Medicine, Baltimore, Maryland.

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January 2020

Long Interspersed Nuclear Element 1 Retrotransposons Become Deregulated during the Development of Ovarian Cancer Precursor Lesions.

Am J Pathol 2019 03 13;189(3):513-520. Epub 2018 Dec 13.

Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Baltimore, Maryland; Department of Pathology, Sidney Kimmel Comprehensive Cancer Center, Baltimore, Maryland; Department of Gynecology and Obstetrics, Sidney Kimmel Comprehensive Cancer Center, Baltimore, Maryland. Electronic address:

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March 2019

Proteome-wide Tyrosine Phosphorylation Analysis Reveals Dysregulated Signaling Pathways in Ovarian Tumors.

Mol Cell Proteomics 2019 03 6;18(3):448-460. Epub 2018 Dec 6.

From the ‡Department of Pharmacology & Molecular Sciences, Johns Hopkins School of Medicine, Baltimore, Maryland 21205;

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March 2019

T cell-inflamed phenotype and increased Foxp3 expression in infiltrating T-cells of mismatch-repair deficient endometrial cancers.

Mod Pathol 2019 04 6;32(4):576-584. Epub 2018 Nov 6.

Department of Oncology, Sidney Kimmel Cancer Center, Johns Hopkins School of Medicine, Baltimore, MD, USA.

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April 2019

Loss of ARID1A expression in endometrial samplings is associated with the risk of endometrial carcinoma.

Gynecol Oncol 2018 09 4;150(3):426-431. Epub 2018 Jul 4.

Kelly Gynecologic Oncology Service, Department of Gynecology and Obstetrics, Johns Hopkins School of Medicine, Baltimore, MD, United States of America.

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September 2018

Methylomic Analysis of Ovarian Cancers Identifies Tumor-Specific Alterations Readily Detectable in Early Precursor Lesions.

Clin Cancer Res 2018 12 14;24(24):6536-6547. Epub 2018 Aug 14.

Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland.

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December 2018

Independent development of endometrial epithelium and stroma within the same endometriosis.

J Pathol 2018 07 2;245(3):265-269. Epub 2018 May 2.

Department of Oncology, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA.

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July 2018

International Society of Gynecological Pathologists (ISGyP) Endometrial Cancer Project: Guidelines From the Special Techniques and Ancillary Studies Group.

Int J Gynecol Pathol 2019 Jan;38 Suppl 1:S114-S122

MD Anderson Cancer Center, Houston, Texas (R.B., A.Y., A.M.) University of Michigan Medical School, Ann Arbor, Michigan (K.R.C.) Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania (K.C.) Bergonie Institute, Bordeaux, France (S.C.) The Ottawa Hospital, University of Ottawa, Ottawa (B.D.) Toronto General Hospital, Toronto (P.S., B.C.), Ontario Department of Pathology, University of Calgary, Calgary, Alberta (M.K.), Canada Edinburgh Cancer Research Centre, Edinburgh (S.H.) Belfast Health and Social Care Trust, Belfast (W.G.M.), UK Brigham and Women's Hospital (B.H., B.J.Q.) Massachusetts General Hospital, Harvard University (E.O.), Boston, Massachusetts Yale New Haven Hospital, New Haven, Connecticut (P.H., V.P.) Department of Pathology, University of Hong Kong, Hong Kong, China (P.I.) Department of Pathology, Medical University of Graz, Graz, Austria (S.L.) Bellvitge University Hospital, IDIBELL, Barcelona (A.V., X.M.G.) Hospital Universitari Arnau de Vilanova, University of Lleida, IRBLLEIDA, Lleida (X.M.G.), CIBERONC, Spain Weill Cornell Medical College, New York, New York (L.H.E.) Stanford University Medical Center, Stanford, California (T.A.L.) Johns Hopkins University School of Medicine, Baltimore, Maryland (I.M.S.).

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January 2019

CINdex: A Bioconductor Package for Analysis of Chromosome Instability in DNA Copy Number Data.

Cancer Inform 2017 13;16:1176935117746637. Epub 2017 Dec 13.

Innovation Center for Biomedical Informatics, Georgetown University, Washington, DC, USA.

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December 2017

Tumor-associated macrophages and the tumor immune microenvironment of primary and recurrent epithelial ovarian cancer.

Hum Pathol 2018 04 27;74:135-147. Epub 2017 Dec 27.

Bloomberg-Kimmel Institute at Johns Hopkins, Baltimore, MD 21287; Department of Oncology, Johns Hopkins Hospital, Baltimore, MD 21287. Electronic address:

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April 2018

Precancerous Lesions of Ovarian Cancer-A US Perspective.

J Natl Cancer Inst 2018 07;110(7):692-693

The Breast and Ovarian Cancer Program, Sidney Kimmel Comprehensive Cancer Center.

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July 2018

The novel ZIP4 regulation and its role in ovarian cancer.

Oncotarget 2017 Oct 30;8(52):90090-90107. Epub 2017 Sep 30.

Department of Obstetrics and Gynecology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.

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October 2017

Endometriosis: benign, malignant, or something in between?

Oncotarget 2017 Oct 19;8(45):78263-78264. Epub 2017 Sep 19.

Ie-Ming Shih: Departments of Pathology, Gynecology and Obstetrics, Johns Hopkins Medical Institutions, Baltimore, MD, USA.

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October 2017

Mutation of NRAS is a rare genetic event in ovarian low-grade serous carcinoma.

Hum Pathol 2017 10 2;68:87-91. Epub 2017 Sep 2.

Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD 21231; Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, Baltimore, MD 21231; Department of Gynecology and Obstetrics, The Johns Hopkins University School of Medicine, Baltimore, MD 21231. Electronic address:

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October 2017

Cancer-Associated Mutations in Endometriosis without Cancer.

N Engl J Med 2017 05;376(19):1835-1848

From the Departments of Obstetrics and Gynaecology (M.S.A., C.A., C.W., P.J.Y., D.G.H.) and Pathology and Laboratory Medicine (M.S.A., T.M.N., J. Senz, B.T.-C., C.B.G., D.G.H.), University of British Columbia, the Department of Anatomical Pathology, Vancouver General Hospital (T.M.N., H.M.H., J.H., V.L., B.T.-C., A.W., C.B.G., D.G.H.), the Department of Molecular Oncology, British Columbia Cancer Agency (H.M.H., A.L., V.L., N.B., D.G.H.), and the BC Women's Centre for Pelvic Pain and Endometriosis, BC Women's Hospital and Health Centre (F.W., N.O., C.A., C.W., P.J.Y.) - all in Vancouver, BC, Canada; the Department of Oncology (N.P., C.T., K.W.K., L.D., T.-L.W., B.V., I.-M.S.) and Ludwig Center (N.P., Y.W., J.D.C., M.Z., M.P., W.M., A.M., K.W.K., L.D., B.V.), Sidney Kimmel Comprehensive Cancer Center, the Departments of Pathology (N.P., A.A., M.N., L.D.W., T.-L.W., B.V., I.-M.S.) and Gynecology and Obstetrics (J. Segars, I.-M.S.), Johns Hopkins Medical Institutions, Personal Genome Diagnostics (S.J.), and Johns Hopkins University Howard Hughes Medical Institute (B.V.) - all in Baltimore; the Department of Pathology, Seirei Mikatahara Hospital (A.A., H.O.), and the Department of Tumor Pathology, Hamamatsu University School of Medicine (A.A.), Hamamatsu, and the Department of Molecular Pathology, Hiroshima University School of Medicine, Hiroshima (A.A.) - all in Japan; the Department of Pathology, University Medical Center Utrecht, Utrecht, the Netherlands (M.N.); the Departments of Obstetrics and Gynecology (T.S.) and Pathology (R.A., A.H.), Lenox Hill Hospital-Northwell Health (Hofstra University), New York; and the Department of Pathology, Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Tao-Yuan City, Taiwan (R.-C.W.).

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May 2017

Tubal origin of ovarian cancer - the double-edged sword of haemoglobin.

J Pathol 2017 05 23;242(1):3-6. Epub 2017 Mar 23.

Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA.

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May 2017

Cancer Implications for Patients with Endometriosis.

Semin Reprod Med 2017 01 3;35(1):110-116. Epub 2017 Jan 3.

Kelly Gynecologic Oncology Service, Department of Gynecology and Obstetrics, Johns Hopkins Medicine, Baltimore, Maryland.

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January 2017

Ovarian Cancer Chemoresistance Relies on the Stem Cell Reprogramming Factor PBX1.

Cancer Res 2016 11 2;76(21):6351-6361. Epub 2016 Sep 2.

Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, Maryland.

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November 2016

Biologically inspired survival analysis based on integrating gene expression as mediator with genomic variants.

Comput Biol Med 2016 10 31;77:231-9. Epub 2016 Aug 31.

Bradley Department of Electrical and Computer Engineering, Virginia Polytechnic Institute and State University, Arlington, VA 22203, USA. Electronic address:

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October 2016

Increased proliferation in atypical hyperplasia/endometrioid intraepithelial neoplasia of the endometrium with concurrent inactivation of ARID1A and PTEN tumour suppressors.

J Pathol Clin Res 2015 Jul 27;1(3):186-93. Epub 2015 May 27.

Department of PathologyJohns Hopkins Medical InstitutionsBaltimoreMaryland; Department of Gynecology and ObstetricsJohns Hopkins Medical InstitutionsBaltimoreMaryland.

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July 2015

PD-L1 Expression in Human Placentas and Gestational Trophoblastic Diseases.

Int J Gynecol Pathol 2017 Mar;36(2):146-153

Departments of Pathology, Gynecology and Obstetrics (E.V., R.J.K., T.-L.W., I.-M.S.) Oncology (E.V., R.J.K., T.-L.W., I.-M.S.), the Johns Hopkins Medical Institutions, Baltimore, Maryland.

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March 2017

The Dualistic Model of Ovarian Carcinogenesis: Revisited, Revised, and Expanded.

Am J Pathol 2016 Apr;186(4):733-47

Departments of Pathology, Gynecology and Obstetrics and Oncology, Johns Hopkins Medical Institutions, Baltimore, Maryland.

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April 2016

Inactivating ARID1A Tumor Suppressor Enhances TERT Transcription and Maintains Telomere Length in Cancer Cells.

J Biol Chem 2016 Apr 7;291(18):9690-9. Epub 2016 Mar 7.

From the Department of Pathology, the Sidney Kimmel Comprehensive Cancer Center, and the Department of Gynecology/Obstetrics, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231,

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April 2016

ChIP-BIT: Bayesian inference of target genes using a novel joint probabilistic model of ChIP-seq profiles.

Nucleic Acids Res 2016 Apr 23;44(7):e65. Epub 2015 Dec 23.

Bradley Department of Electrical and Computer Engineering, Virginia Polytechnic Institute and State University, 900 North Glebe Road, Arlington, VA 22203, USA

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April 2016

Seromucinous Tumors of the Ovary. What's in a Name?

Int J Gynecol Pathol 2016 Jan;35(1):78-81

Departments of Pathology, Gynecology/Obstetrics, and Oncology, The Johns Hopkins University School of Medicine, The Johns Hopkins Hospital, Baltimore, Maryland.

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January 2016

BACOM2.0 facilitates absolute normalization and quantification of somatic copy number alterations in heterogeneous tumor.

Sci Rep 2015 Sep 9;5:13955. Epub 2015 Sep 9.

Department of Electrical and Computer Engineering, Virginia Polytechnic Institute and State University, Arlington, VA 22203, USA.

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September 2015

Laminin C1 expression by uterine carcinoma cells is associated with tumor progression.

Gynecol Oncol 2015 Nov 3;139(2):338-44. Epub 2015 Sep 3.

Kelly Gynecologic Oncology Service, Department of Gynecology and Obstetrics, Johns Hopkins Medical Institutions, Baltimore, MD, United States; Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD, United States. Electronic address:

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November 2015

Molecular Alterations of TP53 are a Defining Feature of Ovarian High-Grade Serous Carcinoma: A Rereview of Cases Lacking TP53 Mutations in The Cancer Genome Atlas Ovarian Study.

Int J Gynecol Pathol 2016 Jan;35(1):48-55

Departments of Pathology (R.V., I.-M.S., R.J.K.), Division of Gynecologic Pathology Gynecology and Obstetrics (R.V., I.-M.S., R.J.K.) Oncology (I.-M.S., R.J.K.), The Johns Hopkins University School of Medicine and Hospital, Baltimore, Maryland Departments of Surgery (Gynecology Service) (D.A.L.) Pathology (R.A.S.), Memorial Sloan-Kettering Cancer Center, New York, New York Department of Pathology (C.Z.), University of California, San Francisco, California.

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January 2016

Mevalonate Pathway Antagonist Suppresses Formation of Serous Tubal Intraepithelial Carcinoma and Ovarian Carcinoma in Mouse Models.

Clin Cancer Res 2015 Oct 24;21(20):4652-62. Epub 2015 Jun 24.

Department of Pathology, School of Medicine, Johns Hopkins University, Baltimore, Maryland. The Sidney Kimmel Comprehensive Cancer Center, School of Medicine, Johns Hopkins University, Baltimore, Maryland. Department of Gynecology/Obstetrics, School of Medicine, Johns Hopkins University, Baltimore, Maryland.

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October 2015

Inhibition of Spleen Tyrosine Kinase Potentiates Paclitaxel-Induced Cytotoxicity in Ovarian Cancer Cells by Stabilizing Microtubules.

Cancer Cell 2015 Jul 18;28(1):82-96. Epub 2015 Jun 18.

Department of Pathology and Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA; Department of Gynecology and Obstetrics, Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA. Electronic address:

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July 2015

Clonality analysis of combined Brenner and mucinous tumours of the ovary reveals their monoclonal origin.

J Pathol 2015 Oct 23;237(2):146-51. Epub 2015 Jul 23.

Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD, USA.

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October 2015

ARID1A Deficiency Impairs the DNA Damage Checkpoint and Sensitizes Cells to PARP Inhibitors.

Cancer Discov 2015 Jul 11;5(7):752-67. Epub 2015 Jun 11.

Department of Clinical Cancer Prevention, The University of Texas MD Anderson Cancer Center, Houston, Texas. Department of Medical Oncology, Tongji Hospital, Tongji Medical College, The Huazhong University of Science and Technology, Wuhan, P.R. China.

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July 2015

Immunohistochemical expression of ARID1A in penile squamous cell carcinomas: a tissue microarray study of 112 cases.

Hum Pathol 2015 May 12;46(5):761-6. Epub 2015 Feb 12.

Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD 31231; Department of Urology, Johns Hopkins Medical Institutions, Baltimore, MD 31231; Department of Oncology, Johns Hopkins Medical Institutions, Baltimore, MD 31231.

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May 2015

Expression Patterns of VEGF and Flk-1 in Human Endometrium during the Menstrual Cycle.

J Reprod Infertil 2015 Jan-Mar;16(1):3-9

Department of Gynecology and Obstetrics, School of Medicine, Johns Hopkins University, Baltimore, United States.

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February 2015

Adenocarcinoma of Mullerian origin: review of pathogenesis, molecular biology, and emerging treatment paradigms.

Gynecol Oncol Res Pract 2015 12;2. Epub 2015 May 12.

Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Duke Cancer Institute, Duke University Medical Center, Durham, NC 27710 USA.

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May 2016

Notch3 interactome analysis identified WWP2 as a negative regulator of Notch3 signaling in ovarian cancer.

PLoS Genet 2014 Oct 30;10(10):e1004751. Epub 2014 Oct 30.

Departments of Pathology and Gynecology/Obstetrics, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America; Department of Oncology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America.

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October 2014

Precursors of ovarian cancer in the fallopian tube: serous tubal intraepithelial carcinoma--an update.

J Obstet Gynaecol Res 2015 Jan 20;41(1):6-11. Epub 2014 Oct 20.

Departments of Pathology and Gynecology and Obstetrics, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA; Department of Gynecology and Obstetrics, University Hospital Aachen, Aachen, Germany.

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January 2015

KDDN: an open-source Cytoscape app for constructing differential dependency networks with significant rewiring.

Bioinformatics 2015 Jan 30;31(2):287-9. Epub 2014 Sep 30.

Department of Electrical & Computer Engineering, Virginia Tech, Arlington, VA 22203, Departments of Pathology and Oncology, Johns Hopkins University, Baltimore, MD 21231, Research Center for Genetic Medicine, Children's National Medical Center, Washington, DC 20010, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC 20057 and Department of Medicine, Wake Forest University, Winston-Salem, NC 27157, USA.

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January 2015

Characterization of the immune cell repertoire in the normal fallopian tube.

Int J Gynecol Pathol 2014 Nov;33(6):581-91

*Department of Molecular and Translational Medicine (L.A., S.L., F.F., W.V.) ‡Laboratory of Genetic Disorders of Childhood, "A Nocivelli" Institute for Molecular Medicine, Department of Pathology, Spedali Civili of Brescia, Brescia, Italy (D.M.) †Department of Pathology (L.A., I.-M.S., R.J.K.), Johns Hopkins University, Baltimore, Maryland ∥Department of Pathology and Immunology (W.V.), Washington University School of Medicine, Saint Louis, Missouri.

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November 2014

Loss of ALDH1A1 expression is an early event in the pathogenesis of ovarian high-grade serous carcinoma.

Mod Pathol 2015 Mar 12;28(3):437-45. Epub 2014 Sep 12.

1] Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD, USA [2] Department of Gynecology and Obstetrics, Johns Hopkins Medical Institutions, Baltimore, MD, USA.

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March 2015

UNDO: a Bioconductor R package for unsupervised deconvolution of mixed gene expressions in tumor samples.

Bioinformatics 2015 Jan 10;31(1):137-9. Epub 2014 Sep 10.

Department of Electrical and Computer Engineering, Virginia Polytechnic Institute and State University, Arlington, VA 22203, Department of Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Smithville, TX 78957, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC 20057, Departments of Pathology and Oncology, Johns Hopkins University, Baltimore, MD 21231 and Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA.

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January 2015

GATA-3 expression in trophoblastic tissues: an immunohistochemical study of 445 cases, including diagnostic utility.

Am J Surg Pathol 2015 Jan;39(1):101-8

*Department of Pathology, Division of Gynecologic Pathology §§Department of Pathology, Division of Urologic Pathology Departments of ‡Gynecology & Obstetrics §Oncology, The Johns Hopkins University School of Medicine and Hospital ∥Department of Pathology, The Johns Hopkins Bayview Hospital ‡‡Department of International Health, Bloomberg School of Public Health, The Johns Hopkins University School of Medicine, Baltimore, MD †PhenoPath Laboratories, Seattle, WA ¶Department of Pathology, Division of Women's and Perinatal Pathology, Brigham and Women's Hospital, Boston, MA #Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN **Robert J. Tomsich Pathology and Laboratory Medicine Institute, The Cleveland Clinic, Cleveland, OH ††Department of Pathology, South Miami Hospital, Baptist Health, South Miami, FL.

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January 2015

BRAF mutation is associated with a specific cell type with features suggestive of senescence in ovarian serous borderline (atypical proliferative) tumors.

Am J Surg Pathol 2014 Dec;38(12):1603-11

Departments of *Pathology and Gynecology and Obstetrics #Oncology, Johns Hopkins Medical Institutions, Baltimore, MD ¶The Wistar Institute, Philadelphia, PA †Department of Gynecology and Obstetrics, University Hospital Aachen, Aachen, Germany ‡Unit of Virus, Lifestyle and Genes, Danish Cancer Society Research Center ∥Juliane Marie Centre, Rigshospitalet, University of Copenhagen, Copenhagen §Department of Pathology, Hvidovre Hospital, Denmark Gynecologic Clinic, Hvidovre, Denmark.

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December 2014

ARID1A immunohistochemistry improves outcome prediction in invasive urothelial carcinoma of urinary bladder.

Hum Pathol 2014 Nov 23;45(11):2233-9. Epub 2014 Jul 23.

Department of Pathology, Johns Hopkins University, Baltimore 21231, MD; Department of Oncology, Johns Hopkins University, Baltimore 21231, MD; Department of Urology, Johns Hopkins University, Baltimore 21231, MD. Electronic address:

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November 2014

Discovery of a cell: reflections on the checkered history of intermediate trophoblast and update on its nature and pathologic manifestations.

Int J Gynecol Pathol 2014 Jul;33(4):339-47

Departments of Pathology, Gynecology and Obstetrics and Oncology, The Johns Hopkins Medical Institution, Baltimore, Maryland.

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July 2014

Roles of deletion of Arid1a, a tumor suppressor, in mouse ovarian tumorigenesis.

J Natl Cancer Inst 2014 Jul 4;106(7). Epub 2014 Jun 4.

Affiliations of authors: Department of Pathology, Departments of Gynecology and Obstetrics and Oncology, Johns Hopkins University School of Medicine, Baltimore, MD (BG, YSR, RCW, YW, TLW, IMS); Department of Pathology, Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Taoyuan, Taiwan (RCW); Department of Surgery, University of Michigan, Ann Arbor, MI (ZW); Genetics Endocrinology Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD (current address for BG).

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July 2014

The emerging roles of ARID1A in tumor suppression.

Cancer Biol Ther 2014 Jun 11;15(6):655-64. Epub 2014 Mar 11.

Department of Pathology and Pathobiology Graduate Program; Johns Hopkins University School of Medicine; Baltimore, MD USA; Departments of Oncology and Gynecology and Obstetrics; Johns Hopkins University School of Medicine; Baltimore, MD USA.

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June 2014

Long interspersed element-1 protein expression is a hallmark of many human cancers.

Am J Pathol 2014 May 6;184(5):1280-6. Epub 2014 Mar 6.

Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland; High Throughput Biology Center, Johns Hopkins University School of Medicine, Baltimore, Maryland; Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland. Electronic address:

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May 2014