Publications by authors named "Ibrahim Jantan"

100Publications

Antioxidant and Anti-Inflammatory Effects of Genus : A Systematic Review.

Front Pharmacol 2020 27;11:504624. Epub 2020 Nov 27.

Centre for Drug and Herbal Development, Faculty of Pharmacy, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia.

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November 2020

Phyllanthus amarus prevents LPS-mediated BV2 microglial activation via MyD88 and NF-κB signaling pathways.

BMC Complement Med Ther 2020 Jul 1;20(1):202. Epub 2020 Jul 1.

Drug and Herbal Research Centre, Faculty of Pharmacy, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300, Kuala Lumpur, Malaysia.

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July 2020

Lignans and polyphenols of Phyllanthus amarus Schumach & Thonn induce apoptosis in HCT116 human colon cancer cells through caspases-dependent pathway.

Curr Pharm Biotechnol 2020 Jun 12. Epub 2020 Jun 12.

Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz 50300 Kuala Lumpur. Malaysia.

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June 2020

Modulation of cell signaling pathways by Phyllanthus amarus and its major constituents: potential role in the prevention and treatment of inflammation and cancer.

Inflammopharmacology 2020 Feb 2;28(1):1-18. Epub 2019 Dec 2.

Department of Pharmacy, International Islamic University Chittagong, Chittagong, 4318, Bangladesh.

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February 2020

Standardized ethanol extract, essential oil and zerumbone of Zingiber zerumbet rhizome suppress phagocytic activity of human neutrophils.

BMC Complement Altern Med 2019 Nov 21;19(1):331. Epub 2019 Nov 21.

Department of Pharmacy, International Islamic University Chittagong, Chittagong, 4318, Bangladesh.

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November 2019

Phyllanthus amarus protects against spatial memory impairment induced by lipopolysaccharide in mice.

Bioinformation 2019 31;15(8):535-541. Epub 2019 Aug 31.

Drug and Herbal Research Centre,Faculty of Pharmacy,Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz,50300 Kuala Lumpur,Malaysia.

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August 2019

Standardised Extract Reduces Cholesterol Levels and Modulates Oxidative Status in Postmenopausal Rats Fed with Cholesterol Diet Enriched with Repeatedly Heated Palm Oil.

Evid Based Complement Alternat Med 2019 23;2019:7246756. Epub 2019 Sep 23.

Department of Biochemistry, Faculty of Medicine, The National University of Malaysia Medical Centre (UKMMC), Kuala Lumpur, Malaysia.

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September 2019

An Insight Into the Modulatory Effects and Mechanisms of Action of Species and Their Bioactive Metabolites on the Immune System.

Front Pharmacol 2019 7;10:878. Epub 2019 Aug 7.

Department of Pharmacy, Forman Christian College (A Chartered University), Lahore, Pakistan.

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August 2019

Effects of annexin A1 on apoptosis and cell cycle arrest in human leukemic cell lines.

Acta Pharm 2019 Mar;69(1):75-86

School of Pharmacy, Taylor's University, Lakeside Campus,47500 Subang Jaya, Selangor,Malaysia.

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March 2019

Protective Effects of Against Lipopolysaccharide-Induced Neuroinflammation and Cognitive Impairment in Rats.

Front Pharmacol 2019 4;10:632. Epub 2019 Jun 4.

Drug and Herbal Research Centre, Faculty of Pharmacy, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia.

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June 2019

Zerumbone from Zingiber zerumbet inhibits innate and adaptive immune responses in Balb/C mice.

Int Immunopharmacol 2019 Aug 7;73:552-559. Epub 2019 Jun 7.

Department of Pharmacy, Forman Christian College (A Chartered University), Ferozpur Road, Lahore, Pakistan.

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August 2019

Enhanced immunosuppressive effects of 3,5-bis[4(diethoxymethyl)benzylidene]-1-methyl-piperidin-4-one, an α, β-unsaturated carbonyl-based compound as PLGA--PEG nanoparticles.

Drug Des Devel Ther 2019 30;13:1421-1436. Epub 2019 Apr 30.

Department of Pharmaceutical Chemistry, College of Pharmacy, Al Jouf University, Aljouf, Sakaka, Saudi Arabia.

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February 2020

Inhibition of Human Platelet Aggregation and Low-Density Lipoprotein Oxidation by Extract and Its Major Compounds.

Molecules 2019 Apr 13;24(8). Epub 2019 Apr 13.

School of Pharmacy, Faculty of Health and Medical Sciences, Taylor's University, Lakeside Campus, 47500 Subang Jaya, Selangor, Malaysia.

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April 2019

Standardized extract of Zingiber zerumbet suppresses LPS-induced pro-inflammatory responses through NF-κB, MAPK and PI3K-Akt signaling pathways in U937 macrophages.

Phytomedicine 2019 Feb 18;54:195-205. Epub 2018 Sep 18.

Drug and Herbal Research Centre, Faculty of Pharmacy, Universiti Kebangsaan Malaysia, Kuala Lumpur 50300, Malaysia.

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February 2019

Immunosuppressive effects of the standardized extract of Zingiber zerumbet on innate immune responses in Wistar rats.

Phytother Res 2019 Apr 8;33(4):929-938. Epub 2019 Jan 8.

Drug and Herbal Research Centre, Faculty of Pharmacy, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia.

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April 2019

Phyllanthin from Phyllanthus amarus inhibits LPS-induced proinflammatory responses in U937 macrophages via downregulation of NF-κB/MAPK/PI3K-Akt signaling pathways.

Phytother Res 2018 Dec 20;32(12):2510-2519. Epub 2018 Sep 20.

Drug and Herbal Research Center, Faculty of Pharmacy, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia.

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December 2018

Corrigendum: Plant-derived immunomodulators: an insight on their preclinical evaluation and clinical trials.

Front Plant Sci 2018;9:1178. Epub 2018 Aug 13.

Drug and Herbal Research Centre, Faculty of Pharmacy, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia.

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August 2018

Dendritic cells pulsed with generated tumor cell lysate from Phyllanthus amarus Schum. & Thonn. induces anti-tumor immune response.

BMC Complement Altern Med 2018 Aug 6;18(1):232. Epub 2018 Aug 6.

Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300, Kuala Lumpur, Malaysia.

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August 2018

Stimulation of the ATPase activity of Hsp90 by zerumbone modification of its cysteine residues destabilizes its clients and causes cytotoxicity.

Biochem J 2018 08 16;475(15):2559-2576. Epub 2018 Aug 16.

Department of Cell and Developmental Biology, Graduate School of Biostudies, Kyoto University, Kyoto, Japan.

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August 2018

Anti-inflammatory effects of Phyllanthus amarus Schum. & Thonn. through inhibition of NF-κB, MAPK, and PI3K-Akt signaling pathways in LPS-induced human macrophages.

BMC Complement Altern Med 2018 Jul 25;18(1):224. Epub 2018 Jul 25.

Drug and Herbal Research Center, Faculty of Pharmacy, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300, Kuala Lumpur, Malaysia.

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July 2018

Exploring the Leaves of L. as a Source of Potential Anti-inflammatory and Anticancer Agents.

Front Pharmacol 2018 20;9:661. Epub 2018 Jun 20.

Drug and Herbal Research Center, Faculty of Pharmacy, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia.

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June 2018

3,5-Bis[4-(diethoxymethyl)benzylidene]-1-methyl-piperidin-4-one, a Novel Curcumin Analogue, Inhibits Cellular and Humoral Immune Responses in Male Balb/c Mice.

Curr Pharm Biotechnol 2018 ;19(6):468-482

Tissue Engineering Centre, 12th Floor Clinical Block, Universiti Kebangsaan Malaysia Medical Centre, Jalan Yaacob Latiff, Bandar Tun Razak, 56000 Cheras, Kuala Lumpur, Malaysia.

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December 2018

Flavonoids of Artocarpus heterophyllus Lam. heartwood inhibit the innate immune responses of human phagocytes.

J Pharm Pharmacol 2018 Sep 25;70(9):1242-1252. Epub 2018 Jun 25.

Department of Pharmacognosy and Pharmaceutical Botany, Faculty of Pharmaceutical Sciences, Prince of Songkla University, Hat-Yai, Songkhla, Thailand.

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September 2018

Magnoflorine Enhances LPS-Activated Pro-Inflammatory Responses via MyD88-Dependent Pathways in U937 Macrophages.

Planta Med 2018 Nov 15;84(17):1255-1264. Epub 2018 Jun 15.

Drug and Herbal Research Centre, Faculty of Pharmacy, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia.

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November 2018

Immunomodulatory effects of Tinospora crispa extract and its major compounds on the immune functions of RAW 264.7 macrophages.

Int Immunopharmacol 2018 Jul 3;60:141-151. Epub 2018 May 3.

Pharmaceutical Chemistry Department, College of Pharmacy, Jouf University, Aljouf, Sakaka 2014, Saudi Arabia.

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July 2018

Anti-Inflammatory Effects of Hypophyllanthin and Niranthin Through Downregulation of NF-κB/MAPKs/PI3K-Akt Signaling Pathways.

Inflammation 2018 Jun;41(3):984-995

Drug and Herbal Research Center, Faculty of Pharmacy, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300, Kuala Lumpur, Malaysia.

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June 2018

Zerumbone suppresses the activation of inflammatory mediators in LPS-stimulated U937 macrophages through MyD88-dependent NF-κB/MAPK/PI3K-Akt signaling pathways.

Int Immunopharmacol 2018 Feb 5;55:312-322. Epub 2018 Jan 5.

Drug and Herbal Research Centre, Faculty of Pharmacy, Universiti Kebangsaan Malaysia, 50300 Kuala Lumpur, Malaysia.

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February 2018

Composition and Antibacterial Activity of the Essential Oils of Orthosiphon stamineus Benth and Ficus deltoidea Jack against Pathogenic Oral Bacteria.

Molecules 2017 Dec 5;22(12). Epub 2017 Dec 5.

Drug and Herbal Research Centre, Faculty of Pharmacy, Universiti Kebangsaan Malaysia, Kuala Lumpur 50300, Malaysia.

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December 2017

Recent Updates on the Phytochemistry, Pharmacological, and Toxicological Activities of Zingiber zerumbet (L.) Roscoe ex Sm.

Curr Pharm Biotechnol 2017 ;18(9):696-720

Drug and Herbal Research Centre, Faculty of Pharmacy, Universiti Kebangsaan Malaysia, 50300 Kuala Lumpur. Malaysia.

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May 2018

Tocotrienols Stimulate Insulin Secretion of Rat Pancreatic Isolated Islets in a Dynamic Culture.

Curr Pharm Biotechnol 2017 ;18(7):560-568

Department of Physiology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Yaacob Latif, 56000 Kuala Lumpur. Malaysia.

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February 2018

Naturally occurring immunomodulators with antitumor activity: An insight on their mechanisms of action.

Int Immunopharmacol 2017 Sep;50:291-304

Drug and Herbal Research Center, Faculty of Pharmacy, Universiti Kebangsaan Malaysia, 50300 Kuala Lumpur, Malaysia.

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September 2017

Exploring the immunomodulatory and anticancer properties of zerumbone.

Food Funct 2017 Oct;8(10):3410-3431

Drug and Herbal Research Centre, Faculty of Pharmacy, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300 Kuala Lumpur, Malaysia.

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October 2017

Tinospora species: An overview of their modulating effects on the immune system.

J Ethnopharmacol 2017 Jul 16;207:67-85. Epub 2017 Jun 16.

Pharmaceutical Chemistry Department, College of Pharmacy, Al Jouf University, Sakaka Al Jouf 2014, Saudi Arabia.

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July 2017

Rheumatoid arthritis: Recent advances on its etiology, role of cytokines and pharmacotherapy.

Biomed Pharmacother 2017 Aug 3;92:615-633. Epub 2017 Jun 3.

Drug and Herbal Research Centre, Faculty of Pharmacy, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300 Kuala Lumpur, Malaysia. Electronic address:

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August 2017

Designing novel bioconjugates of hydroxyethyl cellulose and salicylates for potential pharmaceutical and pharmacological applications.

Int J Biol Macromol 2017 Oct 16;103:441-450. Epub 2017 May 16.

Department of Sustainable Biomaterials, Macromolecules Innovation Institute, Virginia Tech, 230 Cheatham Hall, Blacksburg 24061, VA, US.

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October 2017

Ethnomedicinal uses, phytochemistry and pharmacological aspects of the genus Premna: a review.

Pharm Biol 2017 Dec;55(1):1715-1739

a Drug and Herbal Research Center, Faculty of Pharmacy , Universiti Kebangsaan Malaysia, Kuala Lumpur , Malaysia.

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December 2017

4,5,4'-Trihydroxychalcone, 8,8'-(ethene-1,2-diyl)-dinaphtalene-1,4,5-triol and rutin from Gynura segetum inhibit phagocytosis, lymphocyte proliferation, cytokine release and nitric oxide production from phagocytic cells.

BMC Complement Altern Med 2017 Apr 11;17(1):211. Epub 2017 Apr 11.

Drug and Herbal Research Center, Faculty of Pharmacy, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300, Kuala Lumpur, Malaysia.

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April 2017

An overview of structure-activity relationship studies of curcumin analogs as antioxidant and anti-inflammatory agents.

Future Med Chem 2017 04 10;9(6):605-626. Epub 2017 Apr 10.

Drug & Herbal Research Centre, Faculty of Pharmacy, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300 Kuala Lumpur, Malaysia.

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April 2017

Immunosuppressive Effects of Natural α,β-Unsaturated Carbonyl-Based Compounds, and Their Analogs and Derivatives, on Immune Cells: A Review.

Front Pharmacol 2017 30;8:22. Epub 2017 Jan 30.

Drug and Herbal Research Centre, Faculty of Pharmacy, Universiti Kebangsaan Malaysia Kuala Lumpur, Malaysia.

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January 2017

Evaluation of multifunctional synthetic tetralone derivatives for treatment of Alzheimer's disease.

Chem Biol Drug Des 2016 Dec 17;88(6):889-898. Epub 2016 Aug 17.

Department of Pharmaceutical Engineering, School of Chemistry, Chemical Engineering and Life Science, Wuhan University of Technology, Wuhan, China.

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December 2016

Phyllanthin from Phyllanthus amarus inhibits cellular and humoral immune responses in Balb/C mice.

Phytomedicine 2016 Nov 17;23(12):1441-1450. Epub 2016 Aug 17.

Drug and Herbal Research Center, Faculty of Pharmacy, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300 Kuala Lumpur, Malaysia.

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November 2016

Anti-inflammatory trends of new benzimidazole derivatives.

Future Med Chem 2016 Oct 21;8(16):1953-1967. Epub 2016 Sep 21.

Department of Chemistry, University of Malaya, 50603 Kuala Lumpur, Malaysia.

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October 2016

Effects of Tocotrienols on Insulin Secretion-Associated Genes Expression of Rat Pancreatic Islets in a Dynamic Culture.

Front Pharmacol 2016 30;7:291. Epub 2016 Aug 30.

Drug and Herbal Research Center, Faculty of Pharmacy, Universiti Kebangsaan Malaysia, Kuala Lumpur Malaysia.

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September 2016

Inhibitory effects of compounds from Phyllanthus amarus on nitric oxide production, lymphocyte proliferation, and cytokine release from phagocytes.

Drug Des Devel Ther 2016 9;10:1935-45. Epub 2016 Jun 9.

Biomedical Science Programme, Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, Kuala Lumpur, Malaysia.

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May 2017

Effects of Labisia pumila var alata extracts on the lipid profile, serum antioxidant status and abdominal aorta of high-cholesterol diet rats.

Phytomedicine 2016 Jul 26;23(8):810-7. Epub 2016 Apr 26.

Drug and Herbal Research Center, Faculty of Pharmacy, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, Kuala Lumpur 50300, Malaysia.

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July 2016

Inhibitory Effects of the Standardized Extract of Phyllanthus amarus on Cellular and Humoral Immune Responses in Balb/C Mice.

Phytother Res 2016 Aug 3;30(8):1330-8. Epub 2016 May 3.

Drug and Herbal Research Center, Faculty of Pharmacy, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300, Kuala Lumpur, Malaysia.

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August 2016

Tinospora crispa (L.) Hook. f. & Thomson: A Review of Its Ethnobotanical, Phytochemical, and Pharmacological Aspects.

Front Pharmacol 2016 21;7:59. Epub 2016 Mar 21.

Drug and Herbal Research Centre, Faculty of Pharmacy, Universiti Kebangsaan Malaysia Kuala Lumpur, Malaysia.

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April 2016

Mimosa pudica L., a High-Value Medicinal Plant as a Source of Bioactives for Pharmaceuticals.

Compr Rev Food Sci Food Saf 2016 Mar 15;15(2):303-315. Epub 2015 Dec 15.

Drug and Herbal Research Centre, Faculty of Pharmacy, Univ. Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300, Kuala Lumpur, Malaysia.

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March 2016

Standardized extract of Tinospora crispa stimulates innate and adaptive immune responses in Balb/c mice.

Food Funct 2016 Mar;7(3):1380-9

Drug and Herbal Research Centre, Faculty of Pharmacy, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300 Kuala Lumpur, Malaysia.

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March 2016

A Comprehensive Review on the Chemotherapeutic Potential of Piceatannol for Cancer Treatment, with Mechanistic Insights.

J Agric Food Chem 2016 Feb 26;64(4):725-37. Epub 2016 Jan 26.

School of Life Sciences, B. S. Abdur Rahman University , Seethakathi Estate, Vandalur, 600048 Chennai, India.

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February 2016

Isolation of Terpenoids from the Stem of Ficus aurantiaca Griff and their Effects on Reactive Oxygen Species Production and Chemotactic Activity of Neutrophils.

Molecules 2016 Jan 5;21(1). Epub 2016 Jan 5.

Drug and Herbal Research Centre, Faculty of Pharmacy, Universiti Kebangsaan Malaysia (UKM), Jalan Raja Muda Abdul Aziz, Kuala Lumpur 50300, Malaysia.

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January 2016

Larvicidal activity, inhibition effect on development, histopathological alteration and morphological aberration induced by seaweed extracts in Aedes aegypti (Diptera: Culicidae).

Asian Pac J Trop Med 2015 Dec 14;8(12):1006-1012. Epub 2015 Nov 14.

Drug and Herbal Research Centre, Faculty of Pharmacy, Universiti Kebangsaan Malaysia, 50300 Kuala Lumpur, Malaysia. Electronic address:

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December 2015

Betulinic Acid: Recent Advances in Chemical Modifications, Effective Delivery, and Molecular Mechanisms of a Promising Anticancer Therapy.

Chem Biol Drug Des 2016 Apr 29;87(4):517-36. Epub 2015 Dec 29.

Faculty of Pharmacy, Universiti, Kebangsaan Malaysia (UKM), The National University of Malaysia, Jalan Raja Muda Abdul Aziz, Kuala Lumpur, 50300, Malaysia.

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April 2016

Synthetic Curcumin Analogs as Inhibitors of β -Amyloid Peptide Aggregation: Potential Therapeutic and Diagnostic Agents for Alzheimer's Disease.

Mini Rev Med Chem 2015 ;15(13):1110-21

Drug and Herbal Research Centre, Faculty of Pharmacy, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300 Kuala Lumpur, Malaysia.

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June 2016

Plant-derived immunomodulators: an insight on their preclinical evaluation and clinical trials.

Front Plant Sci 2015 25;6:655. Epub 2015 Aug 25.

Drug and Herbal Research Centre, Faculty of Pharmacy, Universiti Kebangsaan Malaysia Kuala Lumpur, Malaysia.

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September 2015

Immunosuppressive effects of the standardized extract of Phyllanthus amarus on cellular immune responses in Wistar-Kyoto rats.

Drug Des Devel Ther 2015 26;9:4917-30. Epub 2015 Aug 26.

Drug and Herbal Research Center, Faculty of Pharmacy, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia.

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June 2016

Mosquitocidal and Oviposition Repellent Activities of the Extracts of Seaweed Bryopsis pennata on Aedes aegypti and Aedes albopictus.

Molecules 2015 Aug 4;20(8):14082-102. Epub 2015 Aug 4.

Drug and Herbal Research Centre, Faculty of Pharmacy, Universiti Kebangsaan Malaysia, 50300 Kuala Lumpur, Malaysia.

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August 2015

Immunostimulatory effects of the standardized extract of Tinospora crispa on innate immune responses in Wistar Kyoto rats.

Drug Des Devel Ther 2015 10;9:2961-73. Epub 2015 Jun 10.

Drug and Herbal Research Centre, Faculty of Pharmacy, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, Kuala Lumpur, Malaysia.

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February 2016

Protective effects of the standardized extract of Zingiber officinale on myocardium against isoproterenol-induced biochemical and histopathological alterations in rats.

Pharm Biol 2015 14;53(12):1795-802. Epub 2015 Apr 14.

Faculty of Pharmacy, Drug and Herbal Research Center, Universiti Kebangsaan Malaysia , Kuala Lumpur , Malaysia.

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May 2016

Hydroxypropylcellulose as a novel green reservoir for the synthesis, stabilization, and storage of silver nanoparticles.

Int J Nanomedicine 2015 16;10:2079-88. Epub 2015 Mar 16.

Drug and Herbal Research Centre, Faculty of Pharmacy, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, Kuala Lumpur, Malaysia.

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October 2016

Protective effects of Labisia pumila var. alata on biochemical and histopathological alterations of cardiac muscle cells in isoproterenol-induced myocardial infarction rats.

Molecules 2015 Mar 16;20(3):4746-63. Epub 2015 Mar 16.

Drug and Herbal Research Center, Faculty of Pharmacy, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, Kuala Lumpur 50300, Malaysia.

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March 2015

Effects of Plants and Isolates of Celastraceae Family on Cancer Pathways.

Anticancer Agents Med Chem 2015 ;15(6):681-93

Drug and Herbal Research Center, Faculty of Pharmacy, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300 Kuala Lumpur, Malaysia.

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March 2016

Safety Evaluation of Oral Toxicity of Carica papaya Linn. Leaves: A Subchronic Toxicity Study in Sprague Dawley Rats.

Evid Based Complement Alternat Med 2014 29;2014:741470. Epub 2014 Oct 29.

Drug and Herbal Research Center, Faculty of Pharmacy, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300 Kuala Lumpur, Malaysia.

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December 2014

One pot light assisted green synthesis, storage and antimicrobial activity of dextran stabilized silver nanoparticles.

J Nanobiotechnology 2014 Dec 3;12:53. Epub 2014 Dec 3.

Drug and Herbal Research Centre, Faculty of Pharmacy, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, Kuala Lumpur, 50300, Malaysia.

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December 2014

Molecular docking study on platelet-activating factor antagonistic activity of bioactive compounds isolated from Guttiferae and Ardisia species.

Nat Prod Res 2015 21;29(11):1055-8. Epub 2014 Oct 21.

a Faculty of Pharmacy, Drugs and Herbal Research Centre, Universiti Kebangsaan Malaysia , Jalan Raja Muda Abd. Aziz, 50300 Kuala Lumpur , Malaysia.

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July 2015

Synthesis, Molecular Modeling, and Biological Evaluation of Novel 1, 3-Diphenyl-2-propen-1-one Based Pyrazolines as Anti-inflammatory Agents.

Chem Biol Drug Des 2015 Jun 15;85(6):729-42. Epub 2014 Nov 15.

Department of Chemistry, Vidya Bharati Mahavidyalaya, Amravati, Maharashtra, 444 602, India.

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June 2015

Goniothalamin enhances the ATPase activity of the molecular chaperone Hsp90 but inhibits its chaperone activity.

J Biochem 2015 Mar 7;157(3):161-8. Epub 2014 Oct 7.

Molecular Biology Course, Graduate School of Science and Engineering, Saitama University, Saitama 338-8570, Japan; Faculty of Pharmacy, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300 Kuala Lumpur, Malaysia; and Department of Biotechnology and Life Science, Tokyo University of Agriculture and Technology, 2-24-16 Naka-cho, Koganei, Tokyo 184-8588, Japan

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March 2015

Studies of synthetic chalcone derivatives as potential inhibitors of secretory phospholipase A2, cyclooxygenases, lipoxygenase and pro-inflammatory cytokines.

Drug Des Devel Ther 2014 16;8:1405-18. Epub 2014 Sep 16.

Department of Medical Biology, Faculty of Health Science, UiT The Arctic University of Norway, Tromsø, Norway.

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July 2015

Emerging anticancer potentials of goniothalamin and its molecular mechanisms.

Biomed Res Int 2014 28;2014:536508. Epub 2014 Aug 28.

Faculty of Pharmacy, Universiti Kebangsaan Malaysia (UKM), Jalan Raja Muda Abdul Aziz, 50300 Kualalumpur, Malaysia.

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June 2015

The major bioactive components of seaweeds and their mosquitocidal potential.

Parasitol Res 2014 Sep 14;113(9):3121-41. Epub 2014 Aug 14.

Drug and Herbal Research Centre, Faculty of Pharmacy, Universiti Kebangsaan Malaysia, 50300, Kuala Lumpur, Malaysia,

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September 2014

Inhibition of prostaglandin E(2) production by synthetic minor prenylated chalcones and flavonoids: synthesis, biological activity, crystal structure, and in silico evaluation.

Bioorg Med Chem Lett 2014 Aug 27;24(16):3826-34. Epub 2014 Jun 27.

Drugs and Herbal Research Centre, Faculty of Pharmacy, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300 Kuala Lumpur, Malaysia. Electronic address:

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August 2014

Pharmacological evaluation and docking studies of α,β-unsaturated carbonyl based synthetic compounds as inhibitors of secretory phospholipase A₂, cyclooxygenases, lipoxygenase and proinflammatory cytokines.

Bioorg Med Chem 2014 Aug 2;22(15):4151-61. Epub 2014 Jun 2.

Drug and Herbal Research Centre, Faculty of Pharmacy, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300 Kuala Lumpur, Malaysia.

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August 2014

Biological activity and molecular docking studies of curcumin-related α,β-unsaturated carbonyl-based synthetic compounds as anticancer agents and mushroom tyrosinase inhibitors.

J Agric Food Chem 2014 Jun 10;62(24):5538-47. Epub 2014 Jun 10.

Drug and Herbal Research Centre, Faculty of Pharmacy, Universiti Kebangsaan Malaysia , Jalan Raja Muda Abdul Aziz, 50300 Kuala Lumpur, Malaysia.

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June 2014

Inhibitory effect of selected medicinal plants on the release of pro-inflammatory cytokines in lipopolysaccharide-stimulated human peripheral blood mononuclear cells.

J Nat Med 2014 Jul 6;68(3):647-53. Epub 2014 May 6.

Faculty of Pharmacy, Drug and Herbal Research Center, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300, Kuala Lumpur, Malaysia.

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July 2014

Synthesis and evaluation of chalcone derivatives as inhibitors of neutrophils' chemotaxis, phagocytosis and production of reactive oxygen species.

Chem Biol Drug Des 2014 Feb 28;83(2):198-206. Epub 2013 Oct 28.

Drugs and Herbal Research Centre, Faculty of Pharmacy, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abd. Aziz, 50300, Kuala Lumpur, Malaysia.

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February 2014

In vitro inhibitory effects of Moringa oleifera leaf extract and its major components on chemiluminescence and chemotactic activity of phagocytes.

Nat Prod Commun 2013 Nov;8(11):1559-61

Drug and Herbal Research Center, Faculty of Pharmacy, Universiti Kebangsaan Malaysia, Kuala Lumpur 50300, Malaysia.

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November 2013

Effects of novel diarylpentanoid analogues of curcumin on secretory phospholipase A2 , cyclooxygenases, lipo-oxygenase, and microsomal prostaglandin E synthase-1.

Chem Biol Drug Des 2014 Jun 14;83(6):670-81. Epub 2014 May 14.

Drug and Herbal Research Centre, Faculty of Pharmacy, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300, Kuala Lumpur, Malaysia.

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June 2014

Ficus carica L. (Moraceae): Phytochemistry, Traditional Uses and Biological Activities.

Evid Based Complement Alternat Med 2013 16;2013:974256. Epub 2013 Sep 16.

Drug and Herbal Research Centre, Faculty of Pharmacy, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300 Kuala Lumpur, Malaysia.

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June 2014

Inhibitory Effects of Standardized Extracts of Phyllanthus amarus and Phyllanthus urinaria and Their Marker Compounds on Phagocytic Activity of Human Neutrophils.

Evid Based Complement Alternat Med 2013 2;2013:603634. Epub 2013 May 2.

Drug and Herbal Research Center, Faculty of Pharmacy, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, Kuala Lumpur 50300, Malaysia.

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July 2013

Current prospects of synthetic curcumin analogs and chalcone derivatives against mycobacterium tuberculosis.

Med Chem 2013 Nov;9(7):897-903

Faculty of Pharmacy, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300, Kuala Lumpur, Malaysia.

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November 2013

Correlation between Chemical Composition of Curcuma domestica and Curcuma xanthorrhiza and Their Antioxidant Effect on Human Low-Density Lipoprotein Oxidation.

Evid Based Complement Alternat Med 2012 26;2012:438356. Epub 2012 Nov 26.

Drug and Herbal Research Center, Faculty of Pharmacy, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300 Kuala Lumpur, Malaysia.

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December 2012

Synthesis and effects of pyrazolines and isoxazoles on the phagocytic chemotaxis and release of reactive oxygen species by zymosan stimulated human neutrophils.

Med Chem 2013 Dec;9(8):1091-8

Drug and Herbal Research Center, Faculty of Pharmacy, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300 Kuala Lumpur, Malaysia.

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December 2013

Platelet-activating factor (PAF) antagonistic activity of a new biflavonoid from Garcinia nervosa var. pubescens King.

Molecules 2012 Sep 10;17(9):10893-901. Epub 2012 Sep 10.

Drug and Herbal Research Centre, Faculty of Pharmacy, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300 Kuala Lumpur, Malaysia.

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September 2012

Synthesis and biological evaluation of chalcone derivatives (mini review).

Mini Rev Med Chem 2012 Nov;12(13):1394-403

Drug and Herbal Research Center, Faculty of Pharmacy, Universiti Kebangsaan Malaysia, Kuala Lumpur, 50300, Malaysia.

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November 2012

Anti-inflammatory trends of 1, 3-diphenyl-2-propen-1-one derivatives.

Mini Rev Med Chem 2013 Jan;13(1):87-94

Drug and Herbal Research Centre, Faculty of Pharmacy, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300, Kuala Lumpur, Malaysia.

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January 2013

Benzophenones and xanthones from Garcinia cantleyana var. cantleyana and their inhibitory activities on human low-density lipoprotein oxidation and platelet aggregation.

Phytochemistry 2012 Aug 26;80:58-63. Epub 2012 May 26.

Drug and Herbal Research Center, Faculty of Pharmacy, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300 Kuala Lumpur, Malaysia.

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August 2012

Inhibitory effects of acetylmelodorinol, chrysin and polycarpol from Mitrella kentii on prostaglandin E₂ and Thromboxane B₂ production and platelet activating factor receptor binding.

Molecules 2012 Apr 26;17(5):4824-35. Epub 2012 Apr 26.

Drug and Herbal Research Centre, Faculty of Pharmacy, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300 Kuala Lumpur, Malaysia.

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April 2012

Repeated dose 28-days oral toxicity study of Carica papaya L. leaf extract in Sprague Dawley rats.

Molecules 2012 Apr 10;17(4):4326-42. Epub 2012 Apr 10.

Herbal Medicine Research Center, Institute for Medical Research, Jalan Pahang 50588, Kuala Lumpur, Malaysia.

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April 2012

Inhibitory activities of compounds from the twigs of Garcinia hombroniana Pierre on human low-density lipoprotein (LDL) oxidation and platelet aggregation.

Phytother Res 2012 Dec 15;26(12):1845-50. Epub 2012 Mar 15.

Drug and Herbal Research Center, Faculty of Pharmacy, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300 Kuala Lumpur, Malaysia.

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December 2012

Effects of diarylpentanoid analogues of curcumin on chemiluminescence and chemotactic activities of phagocytes.

J Pharm Pharmacol 2012 Mar 16;64(3):404-12. Epub 2011 Dec 16.

Drug and Herbal Research Center, Faculty of Pharmacy, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia.

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March 2012

Platelet-activating factor (PAF) receptor binding activity of the roots of Enicosanthellum pulchrum.

Pharm Biol 2012 Mar 21;50(3):284-90. Epub 2011 Nov 21.

Faculty of Pharmacy, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abd. Aziz, 50300 Kuala Lumpur, Malaysia.

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March 2012

Inhibitory effect of compounds from Goniothalamus tapis Miq. and Goniothalamus uvaroides King on platelet-activating factor receptor binding.

Phytother Res 2012 May 17;26(5):687-91. Epub 2011 Oct 17.

Faculty of Pharmacy, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, Kuala Lumpur, 50300, Malaysia.

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May 2012