Ian W Flinn

Ian W Flinn

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Ian W Flinn

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Rituximab plus Lenalidomide in Advanced Untreated Follicular Lymphoma.

N Engl J Med 2018 09;379(10):934-947

From Université Lille, Centre Hospitalier Universitaire (CHU), Groupe de Recherche sur les formes Injectables et les Technologies Associées, Lille (F.M.), CHU Régional de Nancy, Service d'Hématologie, Vandoeuvre lès Nancy (P.F.), Institut Paoli-Calmettes (R.B.) and Department of Pathology, Institut Paoli-Calmettes, Centre de Recherche en Cancerologie de Marseille, INSERM, Centre National de la Recherche Scientifique, Aix-Marseille Université (L.X.), Marseille, Centre Henri Becquerel, Unité 1245 and Département d'Hématologie, Université de Rouen, Rouen (H.T.), Institut d'Hématologie de Basse Normandie, Caen (C.F.), CHU Le Bocage Service d'Hématologie Clinique, Dijon (R.-O.C.), Hôpital Henri Mondor Unité Hémopathies Lymphoïdes, Créteil (C.H.), Centre Hospitalier Départemental Vendée Service d'Onco-Hématologie, La Roche sur Yon (H.M.), Institut Universitaire du Cancer de Toulouse Oncopole Service d'Hématologie, Toulouse (L.Y.), CHU Bordeaux, Service d'Hématologie, Bordeaux (K.B.), Hôpital Saint Louis Service d'Onco-Hématologie, Paris (P.B.), Gustave Roussy Cancer, Villejuif (V.R.), Centre Hospitalier Annecy Genevois Service, Annecy (N.D.), CHU de Nantes-Hôtel Dieu Service d'Hématologie Clinique, Centre de Recherche en Cancerologie et Immunologie, INSERM, Centre National de la Recherche Scientifique, Université de Nantes, Nantes (S.L.G.), Centre Hospitalier Métropole Savoie Service Hématologie, Chambery (G.M.P.), Department of Hematology, CHU Montpellier, University of Montpellier, Montpellier (G.C.), and Hospices Civils de Lyon, Centre Hospitalier Lyon-Sud, University of Lyon, Pierre-Benite (G.A.S.) - all in France; the Department of Lymphoma and Myeloma, University of Texas M.D. Anderson Cancer Center, Houston (N.H.F.); the Department of Medicine, Memorial Sloan Kettering Cancer Center, New York (M.L.P.); the Department of Medicine, Division of Medical Oncology, University of Washington, Seattle (E.N.L.); Sarah Cannon Research Institute-Tennessee Oncology, Nashville (I.W.F.); Washington University School of Medicine, Siteman Cancer Center, St. Louis (N.L.B.); the Department of Hematology, Hospital Universitario de Salamanca and Instituto de Investigación Biomédica de Salamanca, Centro de Investigación Biomédica en Red de Cáncer, Salamanca (A.M.G.-S.), and the Department of Hematology, Hospital Clinic de Barcelona, Barcelona (A.L.-G.) - both in Spain; CHU de Québec, Hôpital de l'Enfant-Jésus, Quebec (J.-F.L.), and British Columbia Cancer Centre for Lymphoid Cancer, University of British Columbia, Vancouver (L.H.S.) - both in Canada; the Department of Hematology and Oncology, Tokai University Hospital, Kanagawa, Japan (K.A.); Instituto Português de Oncologia Lisboa Francisco Gentil Departamento de Hematologia, Lisbon (M.G.S.); the Department of Hematology, CHU Université Catholique de Louvain Namur, Yvoir (M.A.), and the Department of Hematology, Ziekenhuis Netwerk Antwerpen Stuivenberg, Antwerp (P.Z.) - both in Belgium; the Department of Hematology, National Cancer Center Hospital, Tokyo, Japan (K.T.); and Celgene, Summit, NJ (D.L., J.W.).

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http://www.nejm.org/doi/10.1056/NEJMoa1805104
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http://dx.doi.org/10.1056/NEJMoa1805104DOI Listing
September 2018

PI3K inhibitors and the search for the Holy Grail.

Authors:
Ian W Flinn

Blood 2018 07;132(3):240-241

Sarah Cannon Research Institute; Tennessee Oncology.

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http://dx.doi.org/10.1182/blood-2018-05-848374DOI Listing
July 2018

Bendamustine, bortezomib and rituximab produces durable complete remissions in patients with previously untreated, low grade lymphoma.

Br J Haematol 2018 02 28;180(3):365-373. Epub 2017 Nov 28.

Sarah Cannon Research Institute/Tennessee Oncology PLLC, Nashville, TN, USA.

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http://dx.doi.org/10.1111/bjh.15044DOI Listing
February 2018

Axicabtagene Ciloleucel CAR T-Cell Therapy in Refractory Large B-Cell Lymphoma.

N Engl J Med 2017 12 10;377(26):2531-2544. Epub 2017 Dec 10.

From the University of Texas M.D. Anderson Cancer Center, Houston (S.S.N., J.R.W.); H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL (F.L.L., J.C.C.); Washington University and Siteman Cancer Center, St. Louis (N.L.B., A. Ghobadi); University of Miami, Miami (L.J.L., K.V.K.); Stanford University, Stanford (D.B.M., R.L.), City of Hope National Medical Center, Duarte (T.S.), University of California at Los Angeles, Los Angeles (J.M.T.), University of California at San Diego, San Diego (J.E.C.), and Kite Pharma, Santa Monica (A.B., J.R., L.N., Y.J., J.A., M.E., D.C., J.W., W.Y.G.) - all in California; Dana-Farber Cancer Institute, Boston (C.A.J., E.D.J.); Montefiore Medical Center, Bronx (I.B.), and the University of Rochester School of Medicine, Rochester (J.W.F., P.R.) - both in New York; Vanderbilt University Medical Center (O.O.O.) and the Sarah Cannon Research Institute and Tennessee Oncology (I.W.F.), Nashville; Mayo Clinic, Rochester, MN (Y.L., T.E.W.); Loyola University Medical Center, Maywood, IL (P.J.S.); John Theurer Cancer Center, Hackensack University Medical Center, Hackensack, NJ (A. Goy); Cleveland Clinic, Cleveland (B.T.H., M.R.S.); Karmanos Cancer Center, Wayne State University, Detroit (A.D.); University of Iowa Carver College of Medicine, Iowa City (U.F.); Colorado Blood Cancer Institute, Denver (P.M.S.); Banner M.D. Anderson Cancer Center, Gilbert, AZ (J.M.); and Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel (I.A.).

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http://dx.doi.org/10.1056/NEJMoa1707447DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5882485PMC
December 2017

Randomized Phase II Study of R-CHOP With or Without Bortezomib in Previously Untreated Patients With Non-Germinal Center B-Cell-Like Diffuse Large B-Cell Lymphoma.

J Clin Oncol 2017 Nov 1;35(31):3538-3546. Epub 2017 Sep 1.

John P. Leonard, Weill Cornell Medicine and New York Presbyterian Hospital, New York, NY; Kathryn S. Kolibaba, Compass Oncology, Vancouver, WA; Kathryn S. Kolibaba and Nicholas J. DiBella, US Oncology Research, The Woodlands; Robert Collins, University of Texas Southwestern Medical Center, Dallas, TX; James A. Reeves, Florida Cancer Specialists, Fort Myers; Julio Hajdenberg, University of Florida Health Cancer Center at Orlando Health, Orlando, FL; Anil Tulpule, Keck Medicine of University of Southern California; Sven de Vos, University of California at Los Angeles Jonsson Comprehensive Cancer Center, Los Angeles; Tatjana Kolevska, Kaiser Permanente Medical Center Northern California, Vallejo; Robert Robles, Bay Area Cancer Research Group (Diablo Valley Medical Group), Pleasant Hill; Andrew Horodner, Cancer Care Associates Medical Group, Redondo Beach, CA; Ian W. Flinn, Sarah Cannon Research Institute, Nashville, TN; Christopher R. Flowers, Winship Cancer Institute of Emory University, Atlanta, GA; Nicholas J. DiBella, Rocky Mountain Cancer Centers, Aurora, CO; Steven W. Papish, Summit Medical Group MD Anderson Cancer Center, Camden, NJ; Parameswaran Venugopal, Rush University Medical Center, Chicago, IL; Amir Tabatabai, York Cancer Center/Cancer Care Associates of York, York, PA; and Jaehong Park, Rachel Neuwirth, George Mulligan, Kaveri Suryanarayan, and Dixie-Lee Esseltine, Millennium Pharmaceuticals, Cambridge, MA.

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http://ascopubs.org/doi/10.1200/JCO.2017.73.2784
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http://dx.doi.org/10.1200/JCO.2017.73.2784DOI Listing
November 2017

Maintenance Therapies in Indolent Lymphomas: should Recent Data Change the Standard of Care?

Curr Treat Options Oncol 2017 03;18(3):16

Tennesee Oncology, Nashville, TN, USA.

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http://dx.doi.org/10.1007/s11864-017-0459-zDOI Listing
March 2017

Chronic lymphocytic leukemia and small lymphocytic lymphoma: two faces of the same disease.

Expert Rev Hematol 2017 Feb 26;10(2):137-146. Epub 2016 Dec 26.

b Tennesee Oncology , Nashville , TN , USA.

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http://dx.doi.org/10.1080/17474086.2017.1270203DOI Listing
February 2017

Community-Based Phase IIIB Trial of Three UPFRONT Bortezomib-Based Myeloma Regimens.

J Clin Oncol 2015 Nov 8;33(33):3921-9. Epub 2015 Jun 8.

Ruben Niesvizky, Weill Cornell Medical College, New York Presbyterian Hospital, New York, NY; Ian W. Flinn, Sarah Cannon Research Institute and Tennessee Oncology, Nashville, TN; Robert Rifkin, US Oncology Research/McKesson Specialty Health, The Woodlands, TX; Nashat Gabrail, Gabrail Cancer Center, Canton, OH; Veena Charu, Pacific Cancer Medical Center, Anaheim, CA; Billy Clowney, Santee Hematology/Oncology, Sumter, SC; James Essell, Sarah Cannon Research Institute and Oncology Hematology Care, Cincinnati, OH; Yousuf Gaffar, University of Maryland-St Joseph Medical Center, Towson, MD; Thomas Warr, Clinic Cancer Care, Great Falls, MT; Rachel Neuwirth, Yanyan Zhu, Jennifer Elliott, Dixie-Lee Esseltine, and Liviu Niculescu, Millennium Pharmaceuticals, Cambridge, MA; and James Reeves, Sarah Cannon Research Institute and Florida Cancer Specialists, Fort Myers, FL.

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http://jco.ascopubs.org/content/early/2015/06/08/JCO.2014.58
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http://jco.ascopubs.org/cgi/doi/10.1200/JCO.2014.58.7618
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http://dx.doi.org/10.1200/JCO.2014.58.7618DOI Listing
November 2015

Dulanermin with rituximab in patients with relapsed indolent B-cell lymphoma: an open-label phase 1b/2 randomised study.

Lancet Haematol 2015 Apr 25;2(4):e166-74. Epub 2015 Mar 25.

Department of Haematology, Peter MacCallum Cancer Centre, East Melbourne, VIC, Australia; Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, Melbourne, VIC, Australia. Electronic address:

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http://dx.doi.org/10.1016/S2352-3026(15)00026-5DOI Listing
April 2015

Otlertuzumab (TRU-016), an anti-CD37 monospecific ADAPTIR(™) therapeutic protein, for relapsed or refractory NHL patients.

Br J Haematol 2015 Jan 22;168(1):38-45. Epub 2014 Aug 22.

Fred Hutchinson Cancer Research Center, University of Washington, Seattle, WA, USA.

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http://doi.wiley.com/10.1111/bjh.13099
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http://dx.doi.org/10.1111/bjh.13099DOI Listing
January 2015

Prognostic information and biological insights in chronic lymphocytic leukemia by high-resolution immunophenotypic analysis of ZAP70.

Cytometry A 2014 Sep 20;85(9):798-808. Epub 2014 May 20.

Pathfinder Biotech, Cleveland, OH; Department of Pathology, University Hospitals Case Medical Center and Case Western Reserve University, Cleveland, OH.

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http://dx.doi.org/10.1002/cyto.a.22485DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4278436PMC
September 2014

Rituximab with or without bevacizumab for the treatment of patients with relapsed follicular lymphoma.

Clin Lymphoma Myeloma Leuk 2014 Aug 28;14(4):277-83. Epub 2014 Feb 28.

Sarah Cannon Research Institute (SCRI), Nashville, TN; Tennessee Oncology PLLC, Nashville, TN.

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http://dx.doi.org/10.1016/j.clml.2014.02.010DOI Listing
August 2014

Active idiotypic vaccination versus control immunotherapy for follicular lymphoma.

J Clin Oncol 2014 Jun 5;32(17):1797-803. Epub 2014 May 5.

Ronald Levy, Andrew J. Gentles, Chih Long Liu, Robert Tibshirani, and Ash A. Alizadeh, Stanford University Medical Center, Palo Alto; Christos E. Emmanouilides and John M. Timmerman, University of California Los Angeles Medical Center, Los Angeles; Lori A. Kunkel, Diane E. Ingolia, and Dan W. Denney Jr, Genitope, Fremont, CA; Kristen N. Ganjoo and Michael J. Robertson, Indiana University Medical Center, Indianapolis, IN; John P. Leonard, Weill Medical College of Cornell University, New York, NY; Julie M. Vose, University of Nebraska Medical Center, Omaha, NE; Ian W. Flinn and Richard F. Ambinder, Johns Hopkins University Oncology Center, Baltimore, MD; Joseph M. Connors, British Columbia Cancer Agency Centre for Lymphoid Cancer, Vancouver, British Columbia; Neil L. Berinstein, Toronto-Sunnybrook Regional Cancer Centre, Toronto, Ontario; Andrew R. Belch, Cross Cancer Institute, Edmonton, Alberta, Canada; Nancy L. Bartlett, Washington University School of Medicine, St Louis, MO; Craig Nichols, Oregon Health Science University, Portland, OR; Stephanie A. Gregory, Rush University Medical Center, Chicago, IL; Brian K. Link, University of Iowa Hospitals and Clinics, Iowa City, IA; David J. Inwards, Mayo Clinic, Rochester, MN; Arnold S. Freedman, Dana-Farber Cancer Institute, Boston, MA; and Jeffrey V. Matous, Rocky Mountain Cancer Centers, Denver, CO.

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http://dx.doi.org/10.1200/JCO.2012.43.9273DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4039868PMC
June 2014

GS-1101: a delta-specific PI3K inhibitor in chronic lymphocytic leukemia.

Curr Hematol Malig Rep 2013 Mar;8(1):22-7

Hematologic Malignancies Research, Sarah Cannon Research Institute, 3322 West End Avenue, Suite 900, Nashville, TN 37203, USA.

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http://dx.doi.org/10.1007/s11899-012-0142-1DOI Listing
March 2013

B-cell receptor pathobiology and targeting in NHL.

Curr Oncol Rep 2012 Oct;14(5):411-8

Sarah Cannon Research Institute, 3322 West End Avenue, Suite 900, Nashville, TN, 37203, USA.

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http://dx.doi.org/10.1007/s11912-012-0254-8DOI Listing
October 2012

Novel targeted agents and the need to refine clinical end points in chronic lymphocytic leukemia.

J Clin Oncol 2012 Aug 9;30(23):2820-2. Epub 2012 Jul 9.

Lombardi Comprehensive Cancer Center, Georgetown University Hospital, Washington, DC, USA.

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http://dx.doi.org/10.1200/JCO.2012.43.3748DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3410400PMC
August 2012

CD37: the comeback kid.

Authors:
Ian W Flinn

Blood 2011 Oct;118(15):4007-8

Sarah Cannon Research Institute, USA.

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http://dx.doi.org/10.1182/blood-2011-08-372268DOI Listing
October 2011

B-cell receptor inhibitors in chronic lymphocytic leukemia.

Authors:
Ian W Flinn

Clin Adv Hematol Oncol 2011 Aug;9(8):605-6

Sarah Cannon Research Institute, Nashville, Tennessee.

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August 2011

Management of symptomatic, untreated chronic lymphocytic leukemia.

Blood Rev 2007 May 13;21(3):143-56. Epub 2006 Nov 13.

Division of Hematologic Malignancies, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S0268960X0600061
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http://dx.doi.org/10.1016/j.blre.2006.10.001DOI Listing
May 2007

Clinical outcome following autologous and allogeneic blood and marrow transplantation for relapsed diffuse large-cell non-Hodgkin's lymphoma.

Biol Blood Marrow Transplant 2006 Sep;12(9):965-72

The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland 21231, USA.

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http://dx.doi.org/10.1016/j.bbmt.2006.05.018DOI Listing
September 2006

Blood and bone marrow transplantation for patients with Hodgkin's and non-Hodgkin's lymphoma.

Cancer Treat Res 2006 ;131:251-81

The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins Bunting-Blaustein Cancer Research Building, 1650 Orleans Street/Room 388, Baltimore, MD 21231-1000, USA.

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http://dx.doi.org/10.1007/978-0-387-29346-2_8DOI Listing
June 2006

Graft-versus-host reactions and the effectiveness of donor lymphocyte infusions.

Biol Blood Marrow Transplant 2006 Apr;12(4):414-21

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Johns Hopkins University, Baltimore, MD 21231, USA.

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http://dx.doi.org/10.1016/j.bbmt.2005.11.520DOI Listing
April 2006

Chronic lymphocytic leukemia.

Hematology Am Soc Hematol Educ Program 2004 :163-83

The Ohio State University, Columbus, OH 43210, USA.

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http://dx.doi.org/10.1182/asheducation-2004.1.163DOI Listing
April 2005

High-dose therapy and blood or marrow transplantation for non-Hodgkin lymphoma with central nervous system involvement.

Biol Blood Marrow Transplant 2005 Feb;11(2):93-100

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, 1650 Orleans St., Baltimore, MD 21231, USA.

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http://dx.doi.org/10.1016/j.bbmt.2004.09.009DOI Listing
February 2005

Outcomes of autologous and allogeneic blood or marrow transplantation for mantle cell lymphoma.

Biol Blood Marrow Transplant 2005 Jan;11(1):39-46

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland 21231, USA.

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http://dx.doi.org/10.1016/j.bbmt.2004.09.007DOI Listing
January 2005