Ian Tannock

Ian Tannock

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Ian Tannock

Publications by authors named "Ian Tannock"

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Immunotherapy for Urothelial Cancer: Where Are the Randomized Trials?

J Clin Oncol 2019 Oct 1;37(29):2587-2591. Epub 2019 Jul 1.

Queen's University, Kingston, Ontario, Canada.

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http://dx.doi.org/10.1200/JCO.18.02257DOI Listing
October 2019

A critique of the fragility index - Authors' reply.

Lancet Oncol 2019 Oct 30;20(10):e554. Epub 2019 Sep 30.

Division of Medical Oncology, Princess Margaret Cancer Centre and University of Toronto, Toronto, ON M5G 2M9, Canada. Electronic address:

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http://dx.doi.org/10.1016/S1470-2045(19)30580-7DOI Listing
October 2019

The fragility of phase 3 trials supporting FDA-approved anticancer medicines: a retrospective analysis.

Lancet Oncol 2019 Aug 8;20(8):1065-1069. Epub 2019 Jul 8.

Division of Medical Oncology, Princess Margaret Cancer Centre and University of Toronto, Toronto, ON, Canada. Electronic address:

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http://dx.doi.org/10.1016/S1470-2045(19)30338-9DOI Listing
August 2019

Adjuvant Radiation Therapy After Radical Nephrectomy in Patients with Localized Renal Cell Carcinoma: A Systematic Review and Meta-analysis.

Eur Urol Oncol 2019 Jul 5;2(4):448-455. Epub 2018 Nov 5.

Centro Universitario Contra el Cáncer, Hospital Universitario, Universidad Autónoma de Nuevo León, Monterrey, Mexico; Department of Medical Oncology, Faculty of Medicine, Queen's University, Kingston, ON, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.euo.2018.10.003DOI Listing
July 2019

Improving Treatment for Advanced Prostate Cancer.

Authors:
Ian F Tannock

N Engl J Med 2019 07;381(2):176-177

From the Division of Medical Oncology, Princess Margaret Cancer Centre and the University of Toronto, Toronto.

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http://dx.doi.org/10.1056/NEJMe1906363DOI Listing
July 2019

Value-Added Decisions in Oncology.

Am Soc Clin Oncol Educ Book 2019 Jan 17;39:122-131. Epub 2019 May 17.

3 Gastrointestinal Oncology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY.

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http://dx.doi.org/10.1200/EDBK_238831DOI Listing
January 2019

Low-Fat Abiraterone Food Effect Is of Great Consequence.

Authors:
Ian F Tannock

J Clin Oncol 2018 10 6;36(30):3058-3059. Epub 2018 Sep 6.

Ian F. Tannock, Princess Margaret Cancer Centre and University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1200/JCO.2018.79.2358DOI Listing
October 2018

The paradox of precision medicine.

Nat Rev Clin Oncol 2018 06;15(6):341-342

Division of Medical Oncology, Princess Margaret Cancer Centre, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1038/s41571-018-0016-0DOI Listing
June 2018

Perceived cognitive impairment in people with colorectal cancer who do and do not receive chemotherapy.

J Cancer Surviv 2018 04 27;12(2):178-185. Epub 2017 Oct 27.

Centre for Medical Psychology and Evidence-based Decision-making, University of Sydney, Level 6, The Lifehouse (C39Z), Sydney, NSW, 2006, Australia.

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http://dx.doi.org/10.1007/s11764-017-0656-6DOI Listing
April 2018

Slogans and donor pages of cancer centres: do they convey discordant messages?

Lancet Oncol 2018 04;19(4):447-448

Shaare Zedek Cancer Center, Jerusalem, Israel; Tel Aviv University School of Medicine, Tel Aviv, Israel. Electronic address:

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http://dx.doi.org/10.1016/S1470-2045(18)30203-1DOI Listing
April 2018

Personal prostate-specific antigen screening and treatment choices for localized prostate cancer among expert physicians.

Can Urol Assoc J 2018 Feb 1;12(2):E59-E63. Epub 2017 Dec 1.

Division of Urology, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada.

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http://dx.doi.org/10.5489/cuaj.4736DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5937408PMC
February 2018

Epidermal growth factor receptor overexpression and outcomes in early breast cancer: A systematic review and a meta-analysis.

Cancer Treat Rev 2018 Jan 31;62:1-8. Epub 2017 Oct 31.

Centro Universitario Contra el Cáncer, Hospital Universitario, Universidad Autónoma de Nuevo León, Monterrey, Mexico; Canadian Cancer Trials Group, Department of Medical Oncology, Faculty of Medicine, Queen's University, Kingston, Ontario, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.ctrv.2017.10.008DOI Listing
January 2018

Abiraterone in Metastatic Prostate Cancer.

Authors:
Ian F Tannock

N Engl J Med 2017 10;377(17):1695

Princess Margaret Cancer Centre, Toronto, ON, Canada

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http://dx.doi.org/10.1056/NEJMc1711029DOI Listing
October 2017

Delivery of meaningful cancer care: a retrospective cohort study assessing cost and benefit with the ASCO and ESMO frameworks.

Lancet Oncol 2017 07 2;18(7):887-894. Epub 2017 Jun 2.

Departments of Oncology and Public Health Sciences, Queen's University, Kingston, ON, Canada. Electronic address:

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http://dx.doi.org/10.1016/S1470-2045(17)30415-1DOI Listing
July 2017

Up-regulation of autophagy is a mechanism of resistance to chemotherapy and can be inhibited by pantoprazole to increase drug sensitivity.

Cancer Chemother Pharmacol 2017 May 4;79(5):959-969. Epub 2017 Apr 4.

Department of Medical Biophysics, University Health Network, University of Toronto, Toronto, ON, Canada.

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http://dx.doi.org/10.1007/s00280-017-3298-5DOI Listing
May 2017

Effects of long-term androgen deprivation therapy on cognitive function over 36 months in men with prostate cancer.

Cancer 2017 01 1;123(2):237-244. Epub 2016 Sep 1.

Department of Medicine, University Health Network, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1002/cncr.30320DOI Listing
January 2017

Can modelling of PSA dynamics accelerate drug development for prostate cancer?

Authors:
Ian F Tannock

Lancet Oncol 2017 01 13;18(1):16-18. Epub 2016 Dec 13.

Division of Medical Oncology, Princess Margaret Cancer Centre and University of Toronto, Toronto, ON, M5G 2M9, Canada. Electronic address:

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http://dx.doi.org/10.1016/S1470-2045(16)30641-6DOI Listing
January 2017

Limits to Precision Cancer Medicine.

N Engl J Med 2017 01;376(1):96-7

AGON-Paris, Paris, France

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http://dx.doi.org/10.1056/NEJMc1613563DOI Listing
January 2017

Relevance of randomised controlled trials in oncology.

Lancet Oncol 2016 Dec;17(12):e560-e567

Canadian Cancer Trials Group and Department of Oncology, Queen's University, Kingston, ON, Canada; Tecnológico de Monterrey School of Medicine, Monterrey, Nuevo León, Mexico.

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http://dx.doi.org/10.1016/S1470-2045(16)30572-1DOI Listing
December 2016

Honorary and ghost authorship in reports of randomised clinical trials in oncology.

Eur J Cancer 2016 10 6;66:1-8. Epub 2016 Aug 6.

Division of Medical Oncology & Hematology, Princess Margaret Cancer Centre, Department of Medicine, University of Toronto, 610 University Ave, Toronto, M5G 2M9, Canada. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S09598049163228
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http://dx.doi.org/10.1016/j.ejca.2016.06.023DOI Listing
October 2016

Limits to Personalized Cancer Medicine.

N Engl J Med 2016 Sep;375(13):1289-94

From the Division of Medical Oncology, Princess Margaret Cancer Centre and the University of Toronto, Toronto (I.F.T.); and AGON-Paris, Paris (J.A.H.).

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http://dx.doi.org/10.1056/NEJMsb1607705DOI Listing
September 2016

Environmental enrichment protects against cognitive impairment following chemotherapy in an animal model.

Behav Neurosci 2016 08 23;130(4):428-36. Epub 2016 Jun 23.

Division of Medical Oncology.

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http://dx.doi.org/10.1037/bne0000155DOI Listing
August 2016

Perceptions of palliative care among patients with advanced cancer and their caregivers.

CMAJ 2016 Jul 18;188(10):E217-E227. Epub 2016 Apr 18.

Division of Medical Oncology (Zimmermann, Krzyzanowska, Leighl, Tannock, Hannon), Department of Medicine, Department of Psychiatry (Zimmermann, Rodin), University of Toronto; Department of Supportive Care (Zimmermann, Swami, Rydall, Rodin, Hannon), Department of Medical Oncology (Krzyzanowska, Tannock), The Campbell Family Cancer Research Institute (Zimmermann, Rodin, Tannock), Princess Margaret Cancer Centre, University Health Network, Toronto, Ont.

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http://dx.doi.org/10.1503/cmaj.151171DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4938707PMC
July 2016

Bias in reporting of randomised clinical trials in oncology.

Eur J Cancer 2016 07 3;61:29-35. Epub 2016 May 3.

Division of Medical Oncology & Hematology, Princess Margaret Cancer Centre, Department of Medicine, University of Toronto, 610 University Ave, Toronto M5G 2M9, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.ejca.2016.03.066DOI Listing
July 2016

Use and misuse of common terminology criteria for adverse events in cancer clinical trials.

BMC Cancer 2016 07 4;16:392. Epub 2016 Jul 4.

Medical Oncology, Princess Margaret Cancer Centre, University of Toronto, Toronto, Canada.

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http://dx.doi.org/10.1186/s12885-016-2408-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4932726PMC
July 2016

Toward Value-Based Pricing to Boost Cancer Research and Innovation.

Cancer Res 2016 06 16;76(11):3127-9. Epub 2016 May 16.

Division of Medical Oncology and Hematology, Princess Margaret Cancer Centre, Toronto, Ontario, Canada. University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1158/0008-5472.CAN-15-3179DOI Listing
June 2016

Role of Autophagy as a Survival Mechanism for Hypoxic Cells in Tumors.

Neoplasia 2016 06;18(6):347-55

Department of Medical Biophysics, University health Network, University of Toronto, Toronto, ON, Canada; Division of Medical Oncology and Hematology, Princess Margaret Hospital and University Health Network, University of Toronto, Toronto, ON, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.neo.2016.04.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4909700PMC
June 2016

The five Rs of chemotherapy.

Authors:
Ian F Tannock

Lancet Oncol 2016 06;17(6):703-705

Division of Medical Oncology and Hematology, Princess Margaret Cancer Centre and University of Toronto, Toronto, ON M5G 2M9, Canada. Electronic address:

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http://dx.doi.org/10.1016/S1470-2045(16)00103-0DOI Listing
June 2016

Mechanisms of Drug Resistance Related to the Microenvironment of Solid Tumors and Possible Strategies to Inhibit Them.

Cancer J 2015 Jul-Aug;21(4):254-62

From the *Department of Medical Biophysics, University Health Network, University of Toronto; †Division of Medical Oncology and Hematology, Princess Margaret Cancer Centre; and ‡University Health Network, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1097/PPO.0000000000000131DOI Listing
May 2016

Meta-Analysis Evaluating the Impact of Site of Metastasis on Overall Survival in Men With Castration-Resistant Prostate Cancer.

J Clin Oncol 2016 05 7;34(14):1652-9. Epub 2016 Mar 7.

Susan Halabi, Hua Ma, Nicole C. Solomon, and Andrew J. Armstrong, Duke University, Durham, NC; William Kevin Kelly, Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, PA; Haojin Zhou, Merck, Beijing, China; Karim Fizazi, Institut Gustave Roussy, University of Paris Sud, Villejuif, France; Catherine M. Tangen, Southwest Oncology Group Statistical Center; Mark Rosenthal, Royal Melbourne Hospital, Melbourne, Victoria, Australia; Daniel P. Petrylak, Yale Cancer Center, New Haven, CT; Maha Hussain, University of Michigan, Ann Arbor, MI; Nicholas J. Vogelzang, US Oncology, Las Vegas, NV; Ian M. Thompson, University of Texas at San Antonio, San Antonio; John C. Araujo and Christopher J. Logothetis, The University of Texas MD Anderson Cancer Center, Houston, TX; Kim N. Chi, British Columbia Cancer Agency-Vancouver Cancer Centre, Vancouver, British Columbia; Ian F. Tannock, Princess Margaret Hospital, University of Toronto, Toronto, Ontario, Canada; Johann de Bono, Institute for Cancer Research, Royal Marsden Hospital, Sutton, Surrey, United Kingdom; Mario A. Eisenberger, Johns Hopkins University-School of Medicine, Oncology Center, Baltimore, MD; Abderrahim Fandi and Shaoyi Li, Celgene Corporation, Summit, NJ; David I. Quinn, University of Southern California Norris Cancer Center, Los Angeles; Eric J. Small, University of California San Francisco, San Francisco, CA; Celestia S. Higano, University of Washington, Seattle, WA; and Michael J. Morris, Memorial Sloan-Kettering Cancer Center New York, NY.

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http://ascopubs.org/doi/10.1200/JCO.2015.65.7270
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http://dx.doi.org/10.1200/JCO.2015.65.7270DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4872320PMC
May 2016

Pretreatment Differences in Intraindividual Variability in Reaction Time between Women Diagnosed with Breast Cancer and Healthy Controls.

J Int Neuropsychol Soc 2016 May 10;22(5):530-9. Epub 2016 Mar 10.

4Department of Supportive Care,Cancer Rehabilitation and Survivorship Program,Princess Margaret Cancer Centre,Toronto, Ontario,Canada.

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http://dx.doi.org/10.1017/S1355617716000126DOI Listing
May 2016

Under-reporting of harm in clinical trials.

Lancet Oncol 2016 05 27;17(5):e209-19. Epub 2016 Apr 27.

Division of Medical Oncology & Hematology, Princess Margaret Cancer Centre, Department of Medicine, University of Toronto, Toronto, ON, Canada.

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http://dx.doi.org/10.1016/S1470-2045(16)00152-2DOI Listing
May 2016

Harms of Intermittent vs Continuous Androgen-Deprivation Therapy for Prostate Cancer.

JAMA Oncol 2016 Apr;2(4):461-2

Princess Margaret Cancer Centre, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1001/jamaoncol.2015.4682DOI Listing
April 2016

A prospective study examining elder-relevant outcomes in older adults with prostate cancer undergoing treatment with chemotherapy or abiraterone.

J Geriatr Oncol 2016 Mar 4;7(2):81-9. Epub 2016 Feb 4.

Princess Margaret Cancer Centre, University Health Network, Department of Medicine, University of Toronto, Toronto, ON, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.jgo.2016.01.003DOI Listing
March 2016

Study of testosterone-guided androgen deprivation therapy in management of prostate cancer.

Prostate 2016 Feb 2;76(2):235-42. Epub 2015 Nov 2.

Princess Margaret Cancer Centre and University of Toronto, Toronto, Ontario.

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http://dx.doi.org/10.1002/pros.23117DOI Listing
February 2016

Prostate cancer.

Lancet 2016 Jan 11;387(10013):70-82. Epub 2015 Jun 11.

Division of Clinical Studies, The Institute of Cancer Research, London, UK; Prostate Cancer Targeted Therapy Group, Royal Marsden NHS Foundation Trust, Sutton, Surrey, UK. Electronic address:

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http://dx.doi.org/10.1016/S0140-6736(14)61947-4DOI Listing
January 2016

Cognitive Function in Patients With Colorectal Cancer Who Do and Do Not Receive Chemotherapy: A Prospective, Longitudinal, Controlled Study.

J Clin Oncol 2015 Dec 2;33(34):4085-92. Epub 2015 Nov 2.

Janette L. Vardy, Haryana M. Dhillon, Corrinne Renton, and Stephen Clarke, University of Sydney; Janette L. Vardy and Philip Beale, Concord Cancer Centre, Sydney, New South Wales, Australia; Janette L. Vardy, Anna Dodd, and Ian F. Tannock, Princess Margaret Cancer Centre, University of Toronto; Sean B. Rourke, Tsegaye Bekele, and Haibo Zhang, St Michael's Hospital, University of Toronto, Toronto; and Gregory R. Pond, McMaster University, Hamilton, Ontario, Canada.

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http://jco.ascopubs.org/content/early/2015/10/26/JCO.2015.63
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http://jco.ascopubs.org/cgi/doi/10.1200/JCO.2015.63.0905
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http://dx.doi.org/10.1200/JCO.2015.63.0905DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5683012PMC
December 2015

Influence of the proton pump inhibitor lansoprazole on distribution and activity of doxorubicin in solid tumors.

Cancer Sci 2015 Oct 25;106(10):1438-47. Epub 2015 Sep 25.

Ontario Cancer Institute, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1111/cas.12756DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4638015PMC
October 2015

Response.

J Natl Cancer Inst 2015 Oct 17;107(10). Epub 2015 Aug 17.

Princess Margaret Cancer Center, University of Toronto, Toronto, Canada (AO, FVB, AT, IT, EA).

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http://dx.doi.org/10.1093/jnci/djv244DOI Listing
October 2015

Failures in Phase III: Causes and Consequences.

Clin Cancer Res 2015 Oct;21(20):4552-60

Princess Margaret Cancer Centre and University of Toronto, Toronto, Canada.

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http://dx.doi.org/10.1158/1078-0432.CCR-15-0124DOI Listing
October 2015

Benefits of Adjuvant Chemotherapy for Bladder Cancer.

JAMA Oncol 2015 Sep;1(6):727-8

Division of Medical Oncology and Hematology, Princess Margaret Cancer Centre and University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1001/jamaoncol.2015.1210DOI Listing
September 2015

The intra-tumoral relationship between microcirculation, interstitial fluid pressure and liposome accumulation.

J Control Release 2015 Aug 10;211:163-70. Epub 2015 Jun 10.

Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada; STTARR Innovation Centre, Princess Margaret Cancer Centre, Toronto, ON, Canada; Radiation Medicine Program, Princess Margaret Cancer Centre, Toronto, ON, Canada; Department of Radiation Oncology, University of Toronto, Toronto, ON, Canada; Techna Institute, University Health Network, Toronto, ON, Canada.

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https://linkinghub.elsevier.com/retrieve/pii/S01683659150061
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http://dx.doi.org/10.1016/j.jconrel.2015.06.008DOI Listing
August 2015

Long-term impact of androgen-deprivation therapy on physical function and quality of life.

Cancer 2015 Jul 24;121(14):2350-7. Epub 2015 Mar 24.

Department of Medicine, University Health Network, Toronto, Canada.

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http://dx.doi.org/10.1002/cncr.29355DOI Listing
July 2015

Chemotherapy Rescues Hypoxic Tumor Cells and Induces Their Reoxygenation and Repopulation-An Effect That Is Inhibited by the Hypoxia-Activated Prodrug TH-302.

Clin Cancer Res 2015 May 12;21(9):2107-14. Epub 2015 Feb 12.

Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada. Division of Medical Oncology and Hematology, Princess Margaret Cancer Centre, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1158/1078-0432.CCR-14-2298DOI Listing
May 2015

Systemic therapy for non-clear cell renal cell carcinomas: a systematic review and meta-analysis.

Eur Urol 2015 Apr 2;67(4):740-9. Epub 2014 Jun 2.

Division of Medical Oncology and Hematology, Princess Margaret Cancer Centre, Department of Medicine, University of Toronto, Toronto, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.eururo.2014.05.010DOI Listing
April 2015

Radical cystectomy and adjuvant chemotherapy for bladder cancer in the elderly: a population-based study.

Urology 2015 Apr 7;85(4):791-8. Epub 2015 Feb 7.

Department of Oncology, Queen's University, Kingston, Ontario, Canada; Department of Public Health Sciences, Queen's University, Kingston, Ontario, Canada; Division of Cancer Care and Epidemiology, Queen's University Cancer Research Institute, Kingston, Ontario, Canada.

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https://linkinghub.elsevier.com/retrieve/pii/S00904295140140
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http://dx.doi.org/10.1016/j.urology.2014.12.027DOI Listing
April 2015

Influence of censoring on conclusions of trials for women with metastatic breast cancer.

Eur J Cancer 2015 Apr 26;51(6):721-4. Epub 2015 Feb 26.

Division of Medical Oncology and Hematology, Princess Margaret Cancer Centre, Department of Medicine, University of Toronto, Toronto, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.ejca.2014.12.016DOI Listing
April 2015

Memory loss in chemotherapy-treated rats is exacerbated in high-interference conditions and related to suppression of hippocampal neurogenesis.

Behav Brain Res 2015 Mar 18;281:239-44. Epub 2014 Dec 18.

Department of Medical Oncology, University of Toronto, Princess Margaret Hospital, 610 University Ave, Toronto, ON M5G 2M9, Canada; Department of Medical Biophysics, University of Toronto, Princess Margaret Hospital, 610 University Ave, Toronto, ON M5G 2M9, Canada.

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http://dx.doi.org/10.1016/j.bbr.2014.12.028DOI Listing
March 2015

The effect of chemotherapeutic agents on tumor vasculature in subcutaneous and orthotopic human tumor xenografts.

BMC Cancer 2015 Mar 10;15:112. Epub 2015 Mar 10.

Department of Medical Oncology and Hematology, Princess Margaret Cancer Centre and University of Toronto, 610 University Avenue, Toronto, ON, M5G 2 M9, Canada.

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http://dx.doi.org/10.1186/s12885-015-1091-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4363401PMC
March 2015

Efficacy and toxicity of abiraterone and docetaxel in octogenarians with metastatic castration-resistant prostate cancer.

J Geriatr Oncol 2015 Jan 7;6(1):23-8. Epub 2014 Oct 7.

Department of Medical Oncology, Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2M9, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.jgo.2014.09.183DOI Listing
January 2015

Cancer: Resistance through repopulation.

Authors:
Ian F Tannock

Nature 2015 Jan 3;517(7533):152-3. Epub 2014 Dec 3.

Department of Medical Oncology, Princess Margaret Cancer Centre, Toronto, Ontario M5G 2M9, Canada.

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http://dx.doi.org/10.1038/nature14075DOI Listing
January 2015

Outcomes and endpoints in cancer trials: bridging the divide.

Lancet Oncol 2015 Jan 29;16(1):e43-52. Epub 2014 Dec 29.

University of Toronto Princess Margaret Cancer Centre, Toronto, ON, Canada. Electronic address:

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http://dx.doi.org/10.1016/S1470-2045(14)70380-8DOI Listing
January 2015

A phase I trial of pantoprazole in combination with doxorubicin in patients with advanced solid tumors: evaluation of pharmacokinetics of both drugs and tissue penetration of doxorubicin.

Invest New Drugs 2014 Dec 12;32(6):1269-77. Epub 2014 Sep 12.

Division of Medical Oncology and Hematology, Princess Margaret Cancer Centre, Department of Medicine, University of Toronto, 610 University Avenue, M5G 2 M9, Toronto, ON, Canada.

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http://dx.doi.org/10.1007/s10637-014-0159-5DOI Listing
December 2014

Use and misuse of waterfall plots.

J Natl Cancer Inst 2014 Dec 29;106(12). Epub 2014 Oct 29.

Divisions of Medical Oncology and Hematology (TS, AJT, RWJ, FVB, MGM, IFT) and Biostatistics (LW), Princess Margaret Cancer Center, Department of Medicine, University of Toronto, Toronto, Canada; Joint Department of Medical Imaging, University Health Network, Toronto, Canada (MM, TKK, MS, HS).

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http://dx.doi.org/10.1093/jnci/dju331DOI Listing
December 2014

Impact of spin in the abstracts of articles reporting results of randomized controlled trials in the field of cancer: the SPIIN randomized controlled trial.

J Clin Oncol 2014 Dec 17;32(36):4120-6. Epub 2014 Nov 17.

Isabelle Boutron, Sally Hopewell, and Philippe Ravaud, Methods of Therapeutic Evaluation of Chronic Diseases Team, Epidemiology and Biostatistics Sorbonne Paris Cité Research Centre, Unite Mixte de Recherche 1153, L'Institut National de la Santé et de la Recherche Médicale; Isabelle Boutron and Philippe Ravaud, Assistance Publique des Hôpitaux de Paris, Hôpital Hôtel Dieu; Isabelle Boutron and Philippe Ravaud, Paris Descartes University, Sorbonne Paris Cité; Isabelle Boutron, Sally Hopewell, and Philippe Ravaud, French Cochrane Centre, Paris, France; Douglas G. Altman and Sally Hopewell, Centre for Statistics in Medicine, University of Oxford, Oxford, United Kingdom; Francisco Vera-Badillo and Ian Tannock, Princess Margaret Cancer Centre and University of Toronto, Toronto, Ontario, Canada; Philippe Ravaud, Columbia University Mailman School of Public Health, New York, NY.

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http://dx.doi.org/10.1200/JCO.2014.56.7503DOI Listing
December 2014

Simple prognostic score for metastatic castration-resistant prostate cancer with incorporation of neutrophil-to-lymphocyte ratio.

Cancer 2014 Nov 3;120(21):3346-52. Epub 2014 Jul 3.

Divisions of Medical Oncology and Hematology, Princess Margaret Cancer Centre, Department of Medicine, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1002/cncr.28890DOI Listing
November 2014

Risk of incremental toxicities and associated costs of new anticancer drugs: a meta-analysis.

J Clin Oncol 2014 Nov 29;32(32):3634-42. Epub 2014 Sep 29.

Saroj Niraula, CancerCare Manitoba and University of Manitoba, Winnipeg, Manitoba; Eitan Amir, Francisco Vera-Badillo, and Ian F. Tannock, Princess Margaret Hospital and University of Toronto, Toronto, Ontario, Canada; Bostjan Seruga, Institute of Oncology Ljubljana, Ljubljana, Slovenia; and Alberto Ocana, Albacete University Hospital, Albacete, Spain.

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http://dx.doi.org/10.1200/JCO.2014.55.8437DOI Listing
November 2014

Raising concern about the American Society of Clinical Oncology conflict of interest policy amendment.

J Clin Oncol 2014 Oct 4;32(28):3197. Epub 2014 Aug 4.

Princess Margaret Cancer Centre; University of Toronto. Toronto, Ontario, Canada

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http://dx.doi.org/10.1200/JCO.2014.56.2447DOI Listing
October 2014

Retreatment of men with metastatic castrate-resistant prostate cancer with abiraterone.

Prostate 2014 Oct 11;74(14):1462-4. Epub 2014 Aug 11.

Department of Medical Oncology and Hematology, Princess Margaret Cancer Center, University Health Network, Toronto, Canada.

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http://dx.doi.org/10.1002/pros.22861DOI Listing
October 2014

Abiraterone acetate in metastatic castration-resistant prostate cancer: a retrospective review of the Princess Margaret experience of (I) low dose abiraterone and (II) prior ketoconazole.

Eur J Cancer 2014 Sep 16;50(14):2399-407. Epub 2014 Jul 16.

Division of Medical Oncology and Hematology, Princess Margaret Cancer Center, University Health Network, Toronto, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.ejca.2014.06.004DOI Listing
September 2014

Initial biopsy Gleason score as a predictive marker for survival benefit in patients with castration-resistant prostate cancer treated with docetaxel: data from the TAX327 study.

Eur Urol 2014 Aug 11;66(2):330-6. Epub 2013 Aug 11.

Department of Medical Oncology, Erasmus University Medical Center and Erasmus MC Cancer Institute, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.eururo.2013.08.007DOI Listing
August 2014

Assessing adherence to oral chemotherapy using different measurement methods: Lessons learned from capecitabine.

J Oncol Pharm Pract 2014 Aug 9;20(4):249-56. Epub 2013 Sep 9.

Department of Medical Oncology and Hematology, Princess Margaret Cancer Centre, Toronto, Ontario, Canada; Department of Medicine, University of Toronto, Ontario, Canada

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http://dx.doi.org/10.1177/1078155213501100DOI Listing
August 2014

Effect of multifocality and multicentricity on outcome in early stage breast cancer: a systematic review and meta-analysis.

Breast Cancer Res Treat 2014 Jul 14;146(2):235-44. Epub 2014 Jun 14.

Division of Medical Oncology & Hematology, Princess Margaret Cancer Centre, 610 University Avenue, Toronto, ON, M5G 2M9, Canada,

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http://link.springer.com/10.1007/s10549-014-3018-3
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July 2014

Activity of the hypoxia-activated pro-drug TH-302 in hypoxic and perivascular regions of solid tumors and its potential to enhance therapeutic effects of chemotherapy.

Int J Cancer 2014 Jun 13;134(11):2726-34. Epub 2013 Dec 13.

Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada.

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http://doi.wiley.com/10.1002/ijc.28595
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June 2014

Physical exercise prevents suppression of hippocampal neurogenesis and reduces cognitive impairment in chemotherapy-treated rats.

Psychopharmacology (Berl) 2014 Jun 17;231(11):2311-20. Epub 2013 Dec 17.

Baycrest Centre, Rotman Research Institute, 3560 Bathurst St, Toronto, Ontario, Canada, M6A 2E1,

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http://dx.doi.org/10.1007/s00213-013-3394-0DOI Listing
June 2014

Perioperative chemotherapy for muscle-invasive bladder cancer: A population-based outcomes study.

Cancer 2014 Jun 14;120(11):1630-8. Epub 2014 Apr 14.

Division of Cancer Care and Epidemiology, Queen's University Cancer Research Institute; Department of Oncology, Queen's University, Kingston, Ontario, Canada.

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http://dx.doi.org/10.1002/cncr.28510DOI Listing
June 2014

Prognostic role of neutrophil-to-lymphocyte ratio in solid tumors: a systematic review and meta-analysis.

J Natl Cancer Inst 2014 Jun 29;106(6):dju124. Epub 2014 May 29.

Affiliations of authors: Divisions of Medical Oncology and Hematology, Princess Margaret Cancer Centre, Department of Medicine, University of Toronto, Toronto, Canada (AJT, MGM, FEV-B, PA, RL-A, JJK, IFT, EA); Department of Medical Oncology, Institute of Oncology Ljubljana, Slovenia (BS); Medical Oncology University Hospital, Albacete, Spain (AO); University of Alabama, Birmingham Comprehensive Cancer Center, Birmingham, AL (GS); Department of Medical Oncology, Royal Melbourne Hospital, Melbourne, Australia (BT).

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http://dx.doi.org/10.1093/jnci/dju124DOI Listing
June 2014

Early palliative care for patients with advanced cancer: a cluster-randomised controlled trial.

Lancet 2014 May 19;383(9930):1721-30. Epub 2014 Feb 19.

Department of Psychiatry, University of Toronto, Toronto, ON, Canada; Department of Psychosocial Oncology and Palliative Care, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.

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http://dx.doi.org/10.1016/S0140-6736(13)62416-2DOI Listing
May 2014

The role of kinin receptors in cancer and therapeutic opportunities.

Cancer Lett 2014 Apr 11;345(1):27-38. Epub 2013 Dec 11.

Laboratório de Oncologia Experimental, Faculdade de Medicina da Universidade de São Paulo and Instituto do Câncer do Estado de São Paulo, Brazil. Electronic address:

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http://dx.doi.org/10.1016/j.canlet.2013.12.009DOI Listing
April 2014

Tolerability and efficacy of docetaxel in older men with metastatic castrate-resistant prostate cancer (mCRPC) in the TAX 327 trial.

J Geriatr Oncol 2014 Apr 2;5(2):119-26. Epub 2014 Jan 2.

Department of Medical Oncology, Princess Margaret Hospital, University Health Network and the University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1016/j.jgo.2013.12.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4352315PMC
April 2014

Words of wisdom. Re: Intratumor heterogeneity and branched evolution revealed by multiregion sequencing.

Authors:
Ian F Tannock

Eur Urol 2014 Apr;65(4):846-7

Division of Medical Oncology, Princess Margaret Cancer Centre and University of Toronto, Toronto, Canada. Electronic address:

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April 2014

Intra-individual variability in women with breast cancer.

J Int Neuropsychol Soc 2014 Apr 12;20(4):380-90. Epub 2014 Mar 12.

4 Department of Medicine, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1017/S1355617714000125DOI Listing
April 2014

The prognostic importance of metastatic site in men with metastatic castration-resistant prostate cancer.

Eur Urol 2014 Jan 5;65(1):3-6. Epub 2013 Oct 5.

Department of Oncology, McMaster University and Escarpment Cancer Research Institute, Hamilton, Ontario, Canada.

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http://dx.doi.org/10.1016/j.eururo.2013.09.024DOI Listing
January 2014

Androgen receptor expression and outcomes in early breast cancer: a systematic review and meta-analysis.

J Natl Cancer Inst 2014 Jan 22;106(1):djt319. Epub 2013 Nov 22.

Affiliations of authors: Division of Medical Oncology & Hematology, Princess Margaret Cancer Centre, Department of Medicine, University of Toronto, Toronto, Canada (FEV-B, AJT, PdG, ID-P, PLB, MA-M, IFT, AO, EA); Sector of Medical Oncology, Institute of Oncology Ljubljana, Ljubljana, Slovenia (BS); Medical Oncology Department and Translational Research Unit, Albacete University Hospital, Albacete, Spain (AO).

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http://dx.doi.org/10.1093/jnci/djt319DOI Listing
January 2014

Critical evaluation of disease stabilization as a measure of activity of systemic therapy: lessons from trials with arms in which patients do not receive active treatment.

J Clin Oncol 2014 Jan 2;32(3):260-3. Epub 2013 Dec 2.

Institut Curie and Institut National de la Sante et de la Recherche Medicale U900, Paris, France.

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http://dx.doi.org/10.1200/JCO.2013.53.5518DOI Listing
January 2014

Use of the proton pump inhibitor pantoprazole to modify the distribution and activity of doxorubicin: a potential strategy to improve the therapy of solid tumors.

Clin Cancer Res 2013 Dec 18;19(24):6766-76. Epub 2013 Oct 18.

Authors' Affiliations: Department of Medical Biophysics and Division of Medical Oncology and Hematology, Princess Margaret Cancer Centre and University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1158/1078-0432.CCR-13-0128DOI Listing
December 2013

Reply to J. Zhu et al.

J Clin Oncol 2013 Nov 23;31(31):4025. Epub 2013 Sep 23.

CancerCare Manitoba and University of Manitoba, Winnipeg, Manitoba, Canada.

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http://dx.doi.org/10.1200/JCO.2013.52.4546DOI Listing
November 2013

Evolution of clinical trial design in early drug development: systematic review of expansion cohort use in single-agent phase I cancer trials.

J Clin Oncol 2013 Nov 14;31(33):4260-7. Epub 2013 Oct 14.

Arif Manji, Irene Brana, Eitan Amir, Ian F. Tannock, Philippe L. Bedard, Amit Oza, Lillian L. Siu, and Albiruni R. Abdul Razak, Princess Margaret Cancer Centre, University Health Network; George Tomlinson, University of Toronto; and Arif Manji, Hospital for Sick Children, Toronto, and Southlake Regional Health Centre, Newmarket, Ontario, Canada.

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http://dx.doi.org/10.1200/JCO.2012.47.4957DOI Listing
November 2013

Scheduling of paclitaxel and gefitinib to inhibit repopulation for optimal treatment of human cancer cells and xenografts that overexpress the epidermal growth factor receptor.

Cancer Chemother Pharmacol 2013 Sep 14;72(3):585-95. Epub 2013 Jul 14.

Department of Medical Oncology and Hematology, Princess Margaret Hospital, University of Toronto, 610 University Avenue, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1007/s00280-013-2229-3DOI Listing
September 2013

Phase III trials of targeted anticancer therapies: redesigning the concept.

Clin Cancer Res 2013 Sep 23;19(18):4931-40. Epub 2013 Jul 23.

Authors' Affiliation: Division of Medical Oncology and Hematology, Princess Margaret Cancer Centre and the University of Toronto, Toronto, Canada.

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http://dx.doi.org/10.1158/1078-0432.CCR-13-1222DOI Listing
September 2013

Evaluation of treatment benefit: randomized controlled trials and population-based observational research.

J Clin Oncol 2013 Sep 12;31(26):3298-9. Epub 2013 Aug 12.

Queen's University Cancer Research Institute, Kingston, Ontario, Canada.

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http://dx.doi.org/10.1200/JCO.2013.51.5023DOI Listing
September 2013

Distribution of the anticancer drugs doxorubicin, mitoxantrone and topotecan in tumors and normal tissues.

Cancer Chemother Pharmacol 2013 Jul 17;72(1):127-38. Epub 2013 May 17.

Department of Medical Biophysics, Princess Margaret Cancer Centre and University of Toronto, Toronto, Canada.

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http://dx.doi.org/10.1007/s00280-013-2176-zDOI Listing
July 2013

Treatment of prostate cancer with intermittent versus continuous androgen deprivation: a systematic review of randomized trials.

J Clin Oncol 2013 Jun 29;31(16):2029-36. Epub 2013 Apr 29.

CancerCare Manitoba and University of Manitoba, Winnipeg, Manitoba, Canada.

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http://dx.doi.org/10.1200/JCO.2012.46.5492DOI Listing
June 2013

The tumor microenvironment and strategies to improve drug distribution.

Front Oncol 2013 10;3:154. Epub 2013 Jun 10.

Department of Medical Biophysics, University of Toronto , Toronto, ON , Canada.

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http://dx.doi.org/10.3389/fonc.2013.00154DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3677151PMC
June 2013

Influence of concurrent medications on outcomes of men with prostate cancer included in the TAX 327 study.

Can Urol Assoc J 2013 Jan-Feb;7(1-2):E74-81

Division of Medical Oncology, Princess Margaret Hospital/University of Toronto, Toronto, ON;

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http://dx.doi.org/10.5489/cuaj.267DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3650799PMC
May 2013

Breast cancer: Tamoxifen--when more might be better.

Nat Rev Clin Oncol 2013 Mar 5;10(3):125-6. Epub 2013 Feb 5.

Cancer Research UK Cambridge Institute and Department of Oncology, University of Cambridge, Robinson Way, Cambridge CB2 0RE, UK.

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http://dx.doi.org/10.1038/nrclinonc.2013.17DOI Listing
March 2013