Publications by authors named "Ian Sayers"

66Publications

Epithelial cell dysfunction, a major driver of asthma development.

Allergy 2020 08 16;75(8):1902-1917. Epub 2020 Jun 16.

Department of Pathology & Medical Biology, GRIAC Research Institute, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

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http://dx.doi.org/10.1111/all.14421DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7496351PMC
August 2020

Proinflammatory Effects in Human Lung Tissue of Respirable Smoke Extracts from Indoor Cooking in Nepal.

Ann Am Thorac Soc 2020 06;17(6):688-698

Division of Respiratory Medicine, National Institute for Health Research Nottingham Biomedical Research Centre, University of Nottingham, Nottingham, United Kingdom; and.

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http://dx.doi.org/10.1513/AnnalsATS.201911-827OCDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7258415PMC
June 2020

Exposure to lipopolysaccharide (LPS) reduces contractile response of small airways from GSTCD-/- mice.

PLoS One 2019 12;14(9):e0221899. Epub 2019 Sep 12.

Division of Respiratory Medicine, & National Institute for Health Medicine, Nottingham Biomedical Research Centre, University of Nottingham, Nottingham, England, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0221899PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6742219PMC
March 2020

Defining a role for lung function associated gene GSTCD in cell homeostasis.

Respir Res 2019 Aug 1;20(1):172. Epub 2019 Aug 1.

Division of Respiratory Medicine, National Institute for Health Research, Nottingham Biomedical Research Centre, University of Nottingham, Nottingham, UK.

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http://dx.doi.org/10.1186/s12931-019-1146-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6676530PMC
August 2019

Author Correction: New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries.

Authors:
Nick Shrine Anna L Guyatt A Mesut Erzurumluoglu Victoria E Jackson Brian D Hobbs Carl A Melbourne Chiara Batini Katherine A Fawcett Kijoung Song Phuwanat Sakornsakolpat Xingnan Li Ruth Boxall Nicola F Reeve Ma'en Obeidat Jing Hua Zhao Matthias Wielscher Stefan Weiss Katherine A Kentistou James P Cook Benjamin B Sun Jian Zhou Jennie Hui Stefan Karrasch Medea Imboden Sarah E Harris Jonathan Marten Stefan Enroth Shona M Kerr Ida Surakka Veronique Vitart Terho Lehtimäki Richard J Allen Per S Bakke Terri H Beaty Eugene R Bleecker Yohan Bossé Corry-Anke Brandsma Zhengming Chen James D Crapo John Danesh Dawn L DeMeo Frank Dudbridge Ralf Ewert Christian Gieger Amund Gulsvik Anna L Hansell Ke Hao Joshua D Hoffman John E Hokanson Georg Homuth Peter K Joshi Philippe Joubert Claudia Langenberg Xuan Li Liming Li Kuang Lin Lars Lind Nicholas Locantore Jian'an Luan Anubha Mahajan Joseph C Maranville Alison Murray David C Nickle Richard Packer Margaret M Parker Megan L Paynton David J Porteous Dmitry Prokopenko Dandi Qiao Rajesh Rawal Heiko Runz Ian Sayers Don D Sin Blair H Smith María Soler Artigas David Sparrow Ruth Tal-Singer Paul R H J Timmers Maarten Van den Berge John C Whittaker Prescott G Woodruff Laura M Yerges-Armstrong Olga G Troyanskaya Olli T Raitakari Mika Kähönen Ozren Polašek Ulf Gyllensten Igor Rudan Ian J Deary Nicole M Probst-Hensch Holger Schulz Alan L James James F Wilson Beate Stubbe Eleftheria Zeggini Marjo-Riitta Jarvelin Nick Wareham Edwin K Silverman Caroline Hayward Andrew P Morris Adam S Butterworth Robert A Scott Robin G Walters Deborah A Meyers Michael H Cho David P Strachan Ian P Hall Martin D Tobin Louise V Wain

Nat Genet 2019 Jun;51(6):1067

Department of Health Sciences, University of Leicester, Leicester, UK.

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http://dx.doi.org/10.1038/s41588-019-0438-3DOI Listing
June 2019

New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries.

Authors:
Nick Shrine Anna L Guyatt A Mesut Erzurumluoglu Victoria E Jackson Brian D Hobbs Carl A Melbourne Chiara Batini Katherine A Fawcett Kijoung Song Phuwanat Sakornsakolpat Xingnan Li Ruth Boxall Nicola F Reeve Ma'en Obeidat Jing Hua Zhao Matthias Wielscher Stefan Weiss Katherine A Kentistou James P Cook Benjamin B Sun Jian Zhou Jennie Hui Stefan Karrasch Medea Imboden Sarah E Harris Jonathan Marten Stefan Enroth Shona M Kerr Ida Surakka Veronique Vitart Terho Lehtimäki Richard J Allen Per S Bakke Terri H Beaty Eugene R Bleecker Yohan Bossé Corry-Anke Brandsma Zhengming Chen James D Crapo John Danesh Dawn L DeMeo Frank Dudbridge Ralf Ewert Christian Gieger Amund Gulsvik Anna L Hansell Ke Hao Joshua D Hoffman John E Hokanson Georg Homuth Peter K Joshi Philippe Joubert Claudia Langenberg Xuan Li Liming Li Kuang Lin Lars Lind Nicholas Locantore Jian'an Luan Anubha Mahajan Joseph C Maranville Alison Murray David C Nickle Richard Packer Margaret M Parker Megan L Paynton David J Porteous Dmitry Prokopenko Dandi Qiao Rajesh Rawal Heiko Runz Ian Sayers Don D Sin Blair H Smith María Soler Artigas David Sparrow Ruth Tal-Singer Paul R H J Timmers Maarten Van den Berge John C Whittaker Prescott G Woodruff Laura M Yerges-Armstrong Olga G Troyanskaya Olli T Raitakari Mika Kähönen Ozren Polašek Ulf Gyllensten Igor Rudan Ian J Deary Nicole M Probst-Hensch Holger Schulz Alan L James James F Wilson Beate Stubbe Eleftheria Zeggini Marjo-Riitta Jarvelin Nick Wareham Edwin K Silverman Caroline Hayward Andrew P Morris Adam S Butterworth Robert A Scott Robin G Walters Deborah A Meyers Michael H Cho David P Strachan Ian P Hall Martin D Tobin Louise V Wain

Nat Genet 2019 03 25;51(3):481-493. Epub 2019 Feb 25.

Department of Health Sciences, University of Leicester, Leicester, UK.

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http://dx.doi.org/10.1038/s41588-018-0321-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6397078PMC
March 2019

Genetic risk factors for the development of pulmonary disease identified by genome-wide association.

Respirology 2019 03 13;24(3):204-214. Epub 2018 Nov 13.

Division of Respiratory Medicine, NIHR Nottingham Biomedical Research Centre, University of Nottingham, Nottingham, UK.

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http://doi.wiley.com/10.1111/resp.13436
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http://dx.doi.org/10.1111/resp.13436DOI Listing
March 2019

Lung function associated gene Integrator Complex subunit 12 regulates protein synthesis pathways.

BMC Genomics 2017 03 23;18(1):248. Epub 2017 Mar 23.

Division of Respiratory Medicine, School of Medicine, University of Nottingham, Nottingham, NG7 2UH, UK.

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http://dx.doi.org/10.1186/s12864-017-3628-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5364626PMC
March 2017

Genome-wide association analyses for lung function and chronic obstructive pulmonary disease identify new loci and potential druggable targets.

Authors:
Louise V Wain Nick Shrine María Soler Artigas A Mesut Erzurumluoglu Boris Noyvert Lara Bossini-Castillo Ma'en Obeidat Amanda P Henry Michael A Portelli Robert J Hall Charlotte K Billington Tracy L Rimington Anthony G Fenech Catherine John Tineka Blake Victoria E Jackson Richard J Allen Bram P Prins Archie Campbell David J Porteous Marjo-Riitta Jarvelin Matthias Wielscher Alan L James Jennie Hui Nicholas J Wareham Jing Hua Zhao James F Wilson Peter K Joshi Beate Stubbe Rajesh Rawal Holger Schulz Medea Imboden Nicole M Probst-Hensch Stefan Karrasch Christian Gieger Ian J Deary Sarah E Harris Jonathan Marten Igor Rudan Stefan Enroth Ulf Gyllensten Shona M Kerr Ozren Polasek Mika Kähönen Ida Surakka Veronique Vitart Caroline Hayward Terho Lehtimäki Olli T Raitakari David M Evans A John Henderson Craig E Pennell Carol A Wang Peter D Sly Emily S Wan Robert Busch Brian D Hobbs Augusto A Litonjua David W Sparrow Amund Gulsvik Per S Bakke James D Crapo Terri H Beaty Nadia N Hansel Rasika A Mathias Ingo Ruczinski Kathleen C Barnes Yohan Bossé Philippe Joubert Maarten van den Berge Corry-Anke Brandsma Peter D Paré Don D Sin David C Nickle Ke Hao Omri Gottesman Frederick E Dewey Shannon E Bruse David J Carey H Lester Kirchner Stefan Jonsson Gudmar Thorleifsson Ingileif Jonsdottir Thorarinn Gislason Kari Stefansson Claudia Schurmann Girish Nadkarni Erwin P Bottinger Ruth J F Loos Robin G Walters Zhengming Chen Iona Y Millwood Julien Vaucher Om P Kurmi Liming Li Anna L Hansell Chris Brightling Eleftheria Zeggini Michael H Cho Edwin K Silverman Ian Sayers Gosia Trynka Andrew P Morris David P Strachan Ian P Hall Martin D Tobin

Nat Genet 2017 Mar 6;49(3):416-425. Epub 2017 Feb 6.

Department of Health Sciences, University of Leicester, Leicester, UK.

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http://dx.doi.org/10.1038/ng.3787DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5326681PMC
March 2017

Targeted Sequencing of Lung Function Loci in Chronic Obstructive Pulmonary Disease Cases and Controls.

PLoS One 2017 23;12(1):e0170222. Epub 2017 Jan 23.

Genetic Epidemiology Group, Department of Health Sciences, University of Leicester, Leicester, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0170222PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5256917PMC
August 2017

The differential effects of azithromycin on the airway epithelium in vitro and in vivo.

Physiol Rep 2016 Sep;4(18)

Division of Respiratory Medicine, Queen's Medical Centre, University of Nottingham, Nottingham, United Kingdom

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5037914PMC
http://dx.doi.org/10.14814/phy2.12960DOI Listing
September 2016

Expression of polycomb protein BMI-1 maintains the plasticity of basal bronchial epithelial cells.

Physiol Rep 2016 08;4(16)

Division of Respiratory Medicine, Queens Medical Centre University of Nottingham, Nottingham, United Kingdom

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http://dx.doi.org/10.14814/phy2.12847DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5002903PMC
August 2016

Traditional and emerging indicators of cardiovascular risk in chronic obstructive pulmonary disease.

Chron Respir Dis 2016 Aug 10;13(3):247-55. Epub 2016 Mar 10.

Nottingham Respiratory Research Unit and Division of Respiratory Medicine, School of Medicine, University of Nottingham, Nottingham, UK

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http://dx.doi.org/10.1177/1479972316636995DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5720186PMC
August 2016

Sixteen new lung function signals identified through 1000 Genomes Project reference panel imputation.

Nat Commun 2015 Dec 4;6:8658. Epub 2015 Dec 4.

Genetic Epidemiology Group, Department of Health Sciences, University of Leicester, Leicester LE1 7RH, UK.

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http://dx.doi.org/10.1038/ncomms9658DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4686825PMC
December 2015

Response.

FASEB J 2015 Dec;29(12):4759

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http://dx.doi.org/10.1096/fj.15-1201LTERDOI Listing
December 2015

Cigarette Smoke and the Induction of Urokinase Plasminogen Activator Receptor In Vivo: Selective Contribution of Isoforms to Bronchial Epithelial Phenotype.

Am J Respir Cell Mol Biol 2015 Aug;53(2):174-83

1 Division of Respiratory Medicine, University of Nottingham, Queen's Medical Centre, Nottingham, United Kingdom; and.

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http://dx.doi.org/10.1165/rcmb.2014-0296OCDOI Listing
August 2015

Mouse protocadherin-1 gene expression is regulated by cigarette smoke exposure in vivo.

PLoS One 2014 3;9(7):e98197. Epub 2014 Jul 3.

Laboratory of Allergology and Pulmonary Diseases, Department of Pathology and Medical Biology, University of Groningen, University Medical Center Groningen (UMCG), Groningen, the Netherlands; GRIAC research institute, University of Groningen, University Medical Center Groningen (UMCG), Groningen, the Netherlands.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0098197PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4081120PMC
November 2015

Genome-wide association analysis identifies six new loci associated with forced vital capacity.

Authors:
Daan W Loth María Soler Artigas Sina A Gharib Louise V Wain Nora Franceschini Beate Koch Tess D Pottinger Albert Vernon Smith Qing Duan Chris Oldmeadow Mi Kyeong Lee David P Strachan Alan L James Jennifer E Huffman Veronique Vitart Adaikalavan Ramasamy Nicholas J Wareham Jaakko Kaprio Xin-Qun Wang Holly Trochet Mika Kähönen Claudia Flexeder Eva Albrecht Lorna M Lopez Kim de Jong Bharat Thyagarajan Alexessander Couto Alves Stefan Enroth Ernst Omenaas Peter K Joshi Tove Fall Ana Viñuela Lenore J Launer Laura R Loehr Myriam Fornage Guo Li Jemma B Wilk Wenbo Tang Ani Manichaikul Lies Lahousse Tamara B Harris Kari E North Alicja R Rudnicka Jennie Hui Xiangjun Gu Thomas Lumley Alan F Wright Nicholas D Hastie Susan Campbell Rajesh Kumar Isabelle Pin Robert A Scott Kirsi H Pietiläinen Ida Surakka Yongmei Liu Elizabeth G Holliday Holger Schulz Joachim Heinrich Gail Davies Judith M Vonk Mary Wojczynski Anneli Pouta Asa Johansson Sarah H Wild Erik Ingelsson Fernando Rivadeneira Henry Völzke Pirro G Hysi Gudny Eiriksdottir Alanna C Morrison Jerome I Rotter Wei Gao Dirkje S Postma Wendy B White Stephen S Rich Albert Hofman Thor Aspelund David Couper Lewis J Smith Bruce M Psaty Kurt Lohman Esteban G Burchard André G Uitterlinden Melissa Garcia Bonnie R Joubert Wendy L McArdle A Bill Musk Nadia Hansel Susan R Heckbert Lina Zgaga Joyce B J van Meurs Pau Navarro Igor Rudan Yeon-Mok Oh Susan Redline Deborah L Jarvis Jing Hua Zhao Taina Rantanen George T O'Connor Samuli Ripatti Rodney J Scott Stefan Karrasch Harald Grallert Nathan C Gaddis John M Starr Cisca Wijmenga Ryan L Minster David J Lederer Juha Pekkanen Ulf Gyllensten Harry Campbell Andrew P Morris Sven Gläser Christopher J Hammond Kristin M Burkart John Beilby Stephen B Kritchevsky Vilmundur Gudnason Dana B Hancock O Dale Williams Ozren Polasek Tatijana Zemunik Ivana Kolcic Marcy F Petrini Matthias Wjst Woo Jin Kim David J Porteous Generation Scotland Blair H Smith Anne Viljanen Markku Heliövaara John R Attia Ian Sayers Regina Hampel Christian Gieger Ian J Deary H Marike Boezen Anne Newman Marjo-Riitta Jarvelin James F Wilson Lars Lind Bruno H Stricker Alexander Teumer Timothy D Spector Erik Melén Marjolein J Peters Leslie A Lange R Graham Barr Ken R Bracke Fien M Verhamme Joohon Sung Pieter S Hiemstra Patricia A Cassano Akshay Sood Caroline Hayward Josée Dupuis Ian P Hall Guy G Brusselle Martin D Tobin Stephanie J London

Nat Genet 2014 Jul 15;46(7):669-77. Epub 2014 Jun 15.

1] Epidemiology Branch, National Institute of Environmental Health Sciences, US National Institutes of Health, US Department of Health and Human Services, Research Triangle Park, North Carolina, USA. [2].

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http://dx.doi.org/10.1038/ng.3011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4140093PMC
July 2014

Clonally expanded human airway smooth muscle cells exhibit morphological and functional heterogeneity.

Respir Res 2014 May 3;15:57. Epub 2014 May 3.

Division of Respiratory Medicine, University of Nottingham, Queen's Medical Centre, NG7 2UH Nottingham, United Kingdom.

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http://respiratory-research.com/content/15/1/57
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http://dx.doi.org/10.1186/1465-9921-15-57DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4014754PMC
May 2014

The impact of azithromycin therapy on the airway microbiota in asthma.

Thorax 2014 Jul 28;69(7):673-4. Epub 2013 Nov 28.

Department of Respiratory Medicine, University of Nottingham, Nottingham, UK.

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http://dx.doi.org/10.1136/thoraxjnl-2013-204517DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4078717PMC
July 2014

Defining the contribution of SNPs identified in asthma GWAS to clinical variables in asthmatic children.

BMC Med Genet 2013 Sep 25;14:100. Epub 2013 Sep 25.

Division of Respiratory Medicine, Queen's Medical Centre, University of Nottingham, Nottingham NG7 2UH, United Kingdom.

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http://dx.doi.org/10.1186/1471-2350-14-100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3849932PMC
September 2013

GSTCD and INTS12 regulation and expression in the human lung.

PLoS One 2013 18;8(9):e74630. Epub 2013 Sep 18.

Division of Respiratory Medicine, University of Nottingham, Queen's Medical Center, Nottingham, United Kingdom ; James Hogg Research Centre, Institute for Heart and Lung Health, University of British Columbia, Vancouver, British Columbia, Canada.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0074630PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3776747PMC
June 2014

HTR4 gene structure and altered expression in the developing lung.

Respir Res 2013 Jul 26;14:77. Epub 2013 Jul 26.

Division of Respiratory Medicine, University of Nottingham, Queen's Medical Centre, Nottingham NG7 2UH, UK.

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http://dx.doi.org/10.1186/1465-9921-14-77DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3750317PMC
July 2013

IL-33 is more potent than IL-25 in provoking IL-13-producing nuocytes (type 2 innate lymphoid cells) and airway contraction.

J Allergy Clin Immunol 2013 Oct 27;132(4):933-41. Epub 2013 Jun 27.

Medical Research Council Laboratory of Molecular Biology, Hills Road, Cambridge, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2013.05.012DOI Listing
October 2013

Effects of atopy and grass pollen season on histamine H₄ receptor expression in human leukocytes.

Ann Allergy Asthma Immunol 2013 Jul 31;111(1):38-44. Epub 2013 May 31.

Division of Therapeutics and Molecular Medicine, University of Nottingham, Queen's Medical Centre, Nottingham, United Kingdom.

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http://dx.doi.org/10.1016/j.anai.2013.04.017DOI Listing
July 2013

Urokinase receptor orchestrates the plasminogen system in airway epithelial cell function.

Lung 2013 Apr 14;191(2):215-25. Epub 2013 Feb 14.

Division of Therapeutics and Molecular Medicine, University of Nottingham, Nottingham, NG7 2UH, UK.

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http://dx.doi.org/10.1007/s00408-013-9450-zDOI Listing
April 2013

A tailored approach to asthma management: Arg(16) holds the key?

Authors:
Ian Sayers

Clin Sci (Lond) 2013 Apr;124(8):517-9

Division of Therapeutics and Molecular Medicine, University of Nottingham, Queen's Medical Centre, Nottingham NG7 2UH, UK.

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http://dx.doi.org/10.1042/CS20120640DOI Listing
April 2013

Leukotriene B4 receptor locus gene characterisation and association studies in asthma.

BMC Med Genet 2012 Nov 20;13:110. Epub 2012 Nov 20.

Division of Therapeutics and Molecular Medicine, University of Nottingham, Queen's Medical Centre, Nottingham, United Kingdom.

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http://dx.doi.org/10.1186/1471-2350-13-110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3607986PMC
November 2012

Genetic basis for personalized medicine in asthma.

Expert Rev Respir Med 2012 Apr;6(2):223-36

Division of Therapeutics and Molecular Medicine, Nottingham Respiratory Biomedical Research Unit, University of Nottingham, Nottingham, UK.

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http://dx.doi.org/10.1586/ers.12.9DOI Listing
April 2012

Evaluation of differentiated human bronchial epithelial cell culture systems for asthma research.

J Allergy (Cairo) 2012 11;2012:943982. Epub 2012 Jan 11.

Division of Therapeutics and Molecular Medicine, Nottingham Respiratory Biomedical Research Unit, University Hospital of Nottingham, Nottingham NG7 2UH, UK.

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http://dx.doi.org/10.1155/2012/943982DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3263641PMC
August 2012

The role of ALOX5AP, LTA4H and LTB4R polymorphisms in determining baseline lung function and COPD susceptibility in UK smokers.

BMC Med Genet 2011 Dec 29;12:173. Epub 2011 Dec 29.

Division of Therapeutics and Molecular Medicine, Nottingham Respiratory Biomedical Research Unit, University of Nottingham, Queen's Medical Centre, Nottingham, UK.

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http://dx.doi.org/10.1186/1471-2350-12-173DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3267686PMC
December 2011

uPAR regulates bronchial epithelial repair in vitro and is elevated in asthmatic epithelium.

Thorax 2012 Jun 3;67(6):477-87. Epub 2011 Dec 3.

Division of Therapeutics and Molecular Medicine, Nottingham Respiratory Biomedical Research Unit, University Hospital of Nottingham, Nottingham NG7 2UH, UK.

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http://dx.doi.org/10.1136/thoraxjnl-2011-200508DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3358731PMC
June 2012

Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function.

Authors:
María Soler Artigas Daan W Loth Louise V Wain Sina A Gharib Ma'en Obeidat Wenbo Tang Guangju Zhai Jing Hua Zhao Albert Vernon Smith Jennifer E Huffman Eva Albrecht Catherine M Jackson David M Evans Gemma Cadby Myriam Fornage Ani Manichaikul Lorna M Lopez Toby Johnson Melinda C Aldrich Thor Aspelund Inês Barroso Harry Campbell Patricia A Cassano David J Couper Gudny Eiriksdottir Nora Franceschini Melissa Garcia Christian Gieger Gauti Kjartan Gislason Ivica Grkovic Christopher J Hammond Dana B Hancock Tamara B Harris Adaikalavan Ramasamy Susan R Heckbert Markku Heliövaara Georg Homuth Pirro G Hysi Alan L James Stipan Jankovic Bonnie R Joubert Stefan Karrasch Norman Klopp Beate Koch Stephen B Kritchevsky Lenore J Launer Yongmei Liu Laura R Loehr Kurt Lohman Ruth J F Loos Thomas Lumley Khalid A Al Balushi Wei Q Ang R Graham Barr John Beilby John D Blakey Mladen Boban Vesna Boraska Jonas Brisman John R Britton Guy G Brusselle Cyrus Cooper Ivan Curjuric Santosh Dahgam Ian J Deary Shah Ebrahim Mark Eijgelsheim Clyde Francks Darya Gaysina Raquel Granell Xiangjun Gu John L Hankinson Rebecca Hardy Sarah E Harris John Henderson Amanda Henry Aroon D Hingorani Albert Hofman Patrick G Holt Jennie Hui Michael L Hunter Medea Imboden Karen A Jameson Shona M Kerr Ivana Kolcic Florian Kronenberg Jason Z Liu Jonathan Marchini Tricia McKeever Andrew D Morris Anna-Carin Olin David J Porteous Dirkje S Postma Stephen S Rich Susan M Ring Fernando Rivadeneira Thierry Rochat Avan Aihie Sayer Ian Sayers Peter D Sly George Davey Smith Akshay Sood John M Starr André G Uitterlinden Judith M Vonk S Goya Wannamethee Peter H Whincup Cisca Wijmenga O Dale Williams Andrew Wong Massimo Mangino Kristin D Marciante Wendy L McArdle Bernd Meibohm Alanna C Morrison Kari E North Ernst Omenaas Lyle J Palmer Kirsi H Pietiläinen Isabelle Pin Ozren Pola Sbreve Ek Anneli Pouta Bruce M Psaty Anna-Liisa Hartikainen Taina Rantanen Samuli Ripatti Jerome I Rotter Igor Rudan Alicja R Rudnicka Holger Schulz So-Youn Shin Tim D Spector Ida Surakka Veronique Vitart Henry Völzke Nicholas J Wareham Nicole M Warrington H-Erich Wichmann Sarah H Wild Jemma B Wilk Matthias Wjst Alan F Wright Lina Zgaga Tatijana Zemunik Craig E Pennell Fredrik Nyberg Diana Kuh John W Holloway H Marike Boezen Debbie A Lawlor Richard W Morris Nicole Probst-Hensch Jaakko Kaprio James F Wilson Caroline Hayward Mika Kähönen Joachim Heinrich Arthur W Musk Deborah L Jarvis Sven Gläser Marjo-Riitta Järvelin Bruno H Ch Stricker Paul Elliott George T O'Connor David P Strachan Stephanie J London Ian P Hall Vilmundur Gudnason Martin D Tobin

Nat Genet 2011 Sep 25;43(11):1082-90. Epub 2011 Sep 25.

Department of Health Sciences, University of Leicester, Leicester, UK.

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http://dx.doi.org/10.1038/ng.941DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3267376PMC
September 2011

Evidence of a genetic contribution to lung function decline in asthma.

J Allergy Clin Immunol 2011 Sep 12;128(3):479-84. Epub 2011 Jul 12.

Department of Pediatric Pulmonology and Pediatric Allergology, Beatrix Children's Hospital, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

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https://linkinghub.elsevier.com/retrieve/pii/S00916749110086
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http://dx.doi.org/10.1016/j.jaci.2011.05.036DOI Listing
September 2011

A genome-wide association study to identify genetic determinants of atopy in subjects from the United Kingdom.

J Allergy Clin Immunol 2011 Jan 20;127(1):223-31, 231.e1-3. Epub 2010 Nov 20.

Division of Therapeutics and Molecular Medicine, Nottingham Respiratory Biomedical Research Unit, University Hospital of Nottingham, Nottingham, United Kingdom.

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http://linkinghub.elsevier.com/retrieve/pii/S009167491001565
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http://dx.doi.org/10.1016/j.jaci.2010.10.006DOI Listing
January 2011

Can lineage-specific markers be identified to characterize mesenchyme-derived cell populations in the human airways?

Am J Physiol Lung Cell Mol Physiol 2010 Aug 30;299(2):L169-83. Epub 2010 Apr 30.

Univ. of Nottingham, Queen's Medical Centre, UK.

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http://dx.doi.org/10.1152/ajplung.00311.2009DOI Listing
August 2010

Genome-wide association study identifies five loci associated with lung function.

Nat Genet 2010 Jan 13;42(1):36-44. Epub 2009 Dec 13.

Departments of Health Sciences and Genetics, Adrian Building, University of Leicester, Leicester, UK.

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http://dx.doi.org/10.1038/ng.501DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2862965PMC
January 2010

PLAUR polymorphisms and lung function in UK smokers.

BMC Med Genet 2009 Oct 31;10:112. Epub 2009 Oct 31.

Division of Therapeutics & Molecular Medicine, Nottingham Respiratory Biomedical Research Unit, University Hospital of Nottingham, Nottingham, UK.

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http://dx.doi.org/10.1186/1471-2350-10-112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2784766PMC
October 2009

Characterisation of urokinase plasminogen activator receptor variants in human airway and peripheral cells.

BMC Mol Biol 2009 Jul 28;10:75. Epub 2009 Jul 28.

Division of Therapeutics and Molecular Medicine, Nottingham Respiratory Biomedical Research Unit, University of Nottingham, Queen's Medical Centre, Nottingham, NG7 2UH, UK.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2724484PMC
July 2009

PLAUR polymorphisms are associated with asthma, PLAUR levels, and lung function decline.

J Allergy Clin Immunol 2009 Jun 13;123(6):1391-400.e17. Epub 2009 May 13.

Division of Infection, Inflammation and Immunity, School of Medicine, University of Southampton, Southampton, United Kingdom.

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June 2009

Meta-analysis of genome-wide linkage studies of asthma and related traits.

Respir Res 2008 Apr 28;9:38. Epub 2008 Apr 28.

Division of Therapeutics & Molecular Medicine, University Hospital of Nottingham, Nottingham, UK.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2391165PMC
April 2008

Functional polymorphism and differential regulation of CYSLTR1 transcription in human airway smooth muscle and monocytes.

Cell Biochem Biophys 2007 ;47(1):119-30

Division of Therapeutics and Molecular Medicine, Queen's Medical Centre, Nottingham, NG7 2UH, UK.

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January 2008

Alternative promoter use and splice variation in the human histamine H1 receptor gene.

Am J Respir Cell Mol Biol 2006 Jul 16;35(1):118-26. Epub 2006 Feb 16.

Division of Therapeutics and Molecular Medicine, D Floor, South Block, University of Nottingham, Queen's Medical Centre, Nottingham NG7 2UH, United Kingdom.

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http://dx.doi.org/10.1165/rcmb.2005-0408OCDOI Listing
July 2006

The effect of beta2-adrenoceptor agonists on phospholipase C (beta1) signalling in human airway smooth muscle cells.

Eur J Pharmacol 2006 Feb 17;531(1-3):9-12. Epub 2006 Jan 17.

Division of Therapeutics and Molecular Medicine, University Hospital of Nottingham, Nottingham, NG7 2UH, UK.

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February 2006

Pharmacogenetic approaches in the treatment of asthma.

Curr Allergy Asthma Rep 2005 Mar;5(2):101-8

Division of Therapeutics and Molecular Medicine, University Hospital of Nottingham, D Floor, South Block, Nottingham, NG7 2UH, UK.

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March 2005

Suppression of allergic airway disease using mycobacterial lipoglycans.

J Allergy Clin Immunol 2004 Aug;114(2):302-9

Malaghan Institute of Medical Research, Wellington School of Medicine, New Zealand.

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August 2004

The importance of Lys-352 of human immunoglobulin E in FcepsilonRII/CD23 recognition.

J Biol Chem 2004 Aug 15;279(34):35320-5. Epub 2004 Jun 15.

Krebs Institute, Department of Molecular Biology and Biotechnology, University of Sheffield, Sheffield S10 2TN, United Kingdom.

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August 2004