Ian Sabroe

Ian Sabroe

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Ian Sabroe

Ian Sabroe

Publications by authors named "Ian Sabroe"

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A method for transplantation of human HSCs into zebrafish, to replace humanised murine transplantation models.

F1000Res 2018 15;7:594. Epub 2018 May 15.

The Bateson Centre, University of Sheffield, Sheffield, S10 2PT, UK.

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http://dx.doi.org/10.12688/f1000research.14507.2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6008850.2PMC
September 2019

Airway Epithelial Cells Generate Pro-inflammatory Tenascin-C and Small Extracellular Vesicles in Response to TLR3 Stimuli and Rhinovirus Infection.

Front Immunol 2019 21;10:1987. Epub 2019 Aug 21.

Department of Infection, Immunity and Cardiovascular Disease, School of Medicine, Dentistry and Health, University of Sheffield, Sheffield, United Kingdom.

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http://dx.doi.org/10.3389/fimmu.2019.01987DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6712508PMC
August 2019

Physician narratives of illness.

Lancet 2019 Jul 4;394(10192):20-21. Epub 2019 Jul 4.

The Medical School, University of Sheffield, Sheffield S10 2RX, UK.

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http://dx.doi.org/10.1016/S0140-6736(19)31501-6DOI Listing
July 2019

Human Rhinovirus Inhibits Macrophage Phagocytosis of Bacteria in Chronic Obstructive Pulmonary Disease. More Than a Common Cold.

Am J Respir Crit Care Med 2019 Jun;199(12):1451-1452

3 MRC Centre for Inflammation Research University of Edinburgh Edinburgh, United Kingdom.

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http://dx.doi.org/10.1164/rccm.201812-2283EDDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6580668PMC
June 2019

The care of dying people in 16th- and 17th-century England.

Death Stud 2019 Feb 1:1-8. Epub 2019 Feb 1.

a School of Medicine , University of Sheffield and Medical Humanities Sheffield , Sheffield, UK.

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http://dx.doi.org/10.1080/07481187.2018.1541941DOI Listing
February 2019

Toll-like Receptor 3 Is a Therapeutic Target for Pulmonary Hypertension.

Am J Respir Crit Care Med 2019 Jan;199(2):199-210

1 Division of Pulmonary Disease and Critical Care Medicine, Department of Internal Medicine, Virginia Commonwealth University, Richmond, Virginia.

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http://dx.doi.org/10.1164/rccm.201707-1370OCDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6353001PMC
January 2019

DUSP10 Negatively Regulates the Inflammatory Response to Rhinovirus through Interleukin-1β Signaling.

J Virol 2019 01 4;93(2). Epub 2019 Jan 4.

Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield, United Kingdom

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http://jvi.asm.org/lookup/doi/10.1128/JVI.01659-18
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http://dx.doi.org/10.1128/JVI.01659-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6321923PMC
January 2019

Diagnosis of Pulmonary Hypertension with Cardiac MRI: Derivation and Validation of Regression Models.

Radiology 2019 01 23;290(1):61-68. Epub 2018 Oct 23.

From the Academic Department of Radiology, University of Sheffield, Floor C, Royal Hallamshire Hospital, Glossop Rd, Sheffield S10 2JF, England (C.S.J., P.G., R.S., D.A.C., J.M.W., A.J.S.); and Sheffield Pulmonary Vascular Disease Unit (D.G.K., S.R., N.H., C.E., I.S., A.C., R.C.) and Department of Radiology (C.S.J., C.H., S.T., K.K., A.J.S.), Sheffield Teaching Hospitals, Sheffield, England.

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http://dx.doi.org/10.1148/radiol.2018180603DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6314564PMC
January 2019

DP1 receptor signaling prevents the onset of intrinsic apoptosis in eosinophils and functions as a transcriptional modulator.

J Leukoc Biol 2018 07 1;104(1):159-171. Epub 2018 Apr 1.

Otto Loewi Research Center for Vascular Biology, Immunology and Inflammation, Division of Pharmacology, Medical University of Graz, Graz, Austria.

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http://dx.doi.org/10.1002/JLB.3MA1017-404RDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6032830PMC
July 2018

Pathophysiology and Diagnosis of Pulmonary Hypertension Due to Left Heart Disease.

Front Med (Lausanne) 2018 6;5:174. Epub 2018 Jun 6.

Sheffield Pulmonary Vascular Disease Unit, Royal Hallamshire Hospital, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, United Kingdom.

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http://dx.doi.org/10.3389/fmed.2018.00174DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5997828PMC
June 2018

A social-technological epistemology of clinical decision-making as mediated by imaging.

J Eval Clin Pract 2017 Oct 3;23(5):949-958. Epub 2016 Oct 3.

University of Sheffield, Sheffield, UK.

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http://dx.doi.org/10.1111/jep.12637DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5655732PMC
October 2017

Incremental shuttle walk test distance and autonomic dysfunction predict survival in pulmonary arterial hypertension.

J Heart Lung Transplant 2017 Aug 24;36(8):871-879. Epub 2017 Apr 24.

Sheffield Pulmonary Vascular Disease Unit, Sheffield Teaching Hospitals NHS Foundation Trust, Royal Hallamshire Hospital, Sheffield; Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Medical School, Sheffield; Insigneo Institute for in silico Medicine, University of Sheffield, Sheffield, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.healun.2017.04.008DOI Listing
August 2017

Combining creative writing and narrative analysis to deliver new insights into the impact of pulmonary hypertension.

BMJ Open Respir Res 2017 5;4(1):e000184. Epub 2017 Jun 5.

Department of Infection, Immunity and Cardiovascular Science, Faculty of Medicine, Dentistry and Health, University of Sheffield, Sheffield, UK.

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http://dx.doi.org/10.1136/bmjresp-2017-000184DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5531299PMC
June 2017

Bosutinib therapy resulting in severe deterioration of pre-existing pulmonary arterial hypertension.

Eur Respir J 2016 11 22;48(5):1514-1516. Epub 2016 Sep 22.

Pulmonary Vascular Disease Unit, Sheffield Teaching Hospitals NHS Trust, Sheffield, UK

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http://dx.doi.org/10.1183/13993003.01004-2016DOI Listing
November 2016

Pulmonary arterial hypertension associated with congenital heart disease: Comparison of clinical and anatomic-pathophysiologic classification.

J Heart Lung Transplant 2016 05 7;35(5):610-8. Epub 2016 Jan 7.

Sheffield Pulmonary Vascular Disease Unit, Royal Hallamshire Hospital, Sheffield, UK; Academic Department of Respiratory Medicine, University of Sheffield, Sheffield, UK. Electronic address:

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http://dx.doi.org/10.1016/j.healun.2015.12.016DOI Listing
May 2016

A matter of time: study of circadian clocks and their role in inflammation.

J Leukoc Biol 2016 Apr 8;99(4):549-60. Epub 2016 Feb 8.

*Department of Infection, Immunity and Cardiovascular Disease, Faculty of Medicine, Dentistry, and Health, University of Sheffield, United Kingdom; Faculty of Medical and Human Sciences, Institute of Human Development, Manchester, United Kingdom; and Faculty of Life Sciences, University of Manchester, Manchester, United Kingdom.

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http://dx.doi.org/10.1189/jlb.3RU1015-451RDOI Listing
April 2016

Platelet P2Y12 Inhibitors Reduce Systemic Inflammation and Its Prothrombotic Effects in an Experimental Human Model.

Arterioscler Thromb Vasc Biol 2015 Dec 29;35(12):2562-70. Epub 2015 Oct 29.

From the Departments of Cardiovascular Science (M.R.T., S.N.O., G.K.S., R.E.F., R.E., H.M.J., H.K., L.E.W., R.F.S.) and Infection and Immunity (D.H.D., I.S.), University of Sheffield, Sheffield, United Kingdom; and Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, United Kingdom (R.A.A., F.P.).

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http://dx.doi.org/10.1161/ATVBAHA.115.306528DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4663676PMC
December 2015

Phosphoinositide-3 kinase inhibition modulates responses to rhinovirus by mechanisms that are predominantly independent of autophagy.

PLoS One 2014 26;9(12):e116055. Epub 2014 Dec 26.

Academic Unit of Respiratory Medicine, Department of Infection and Immunity, Faculty of Medicine, Dentistry and Health, University of Sheffield, Beech Hill Road, Sheffield, S10 2RX, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0116055PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4277460PMC
November 2015

Management of acute pulmonary embolism.

Br J Hosp Med (Lond) 2015 Oct;76(10):C150-5

Consultant Chest Physician in the Sheffield Pulmonary Vascular Disease Unit, Royal Hallamshire Hospital, Sheffield Teaching Hospitals NHS Foundation Trust Sheffield S10 2JF.

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http://www.magonlinelibrary.com/doi/10.12968/hmed.2015.76.10
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http://dx.doi.org/10.12968/hmed.2015.76.10.C150DOI Listing
October 2015

Ticagrelor potentiates adenosine-induced stimulation of neutrophil chemotaxis and phagocytosis.

Vascul Pharmacol 2015 Aug 11;71:201-7. Epub 2015 Apr 11.

Department of Cardiovascular Science, University of Sheffield, Beech Hill Road, Sheffield S10 2RX, UK.

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http://dx.doi.org/10.1016/j.vph.2015.02.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4534709PMC
August 2015

Macrophage phenotype is associated with disease severity in preterm infants with chronic lung disease.

PLoS One 2014 12;9(8):e103059. Epub 2014 Aug 12.

Academic Unit of Respiratory Medicine, Department of Infection and Immunity, University of Sheffield, Sheffield Teaching Hospitals NHS Trust, Sheffield, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0103059PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4130498PMC
April 2015

Editorial: RSV: a new box of delights for an old enemy.

J Leukoc Biol 2014 Dec;96(6):945-7

Respiratory Infections Section, National Heart and Lung Institute, Faculty of Medicine, Imperial College London, United Kingdom.

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http://dx.doi.org/10.1189/jlb.4CE0714-341RDOI Listing
December 2014

Ambrisentan therapy in pulmonary hypertension: clinical use and tolerability in a referral centre.

Ther Adv Respir Dis 2014 Jun 30;8(3):71-77. Epub 2014 Apr 30.

Pulmonary Vascular Disease Unit, Royal Hallamshire Hospital, Sheffield, UK.

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http://dx.doi.org/10.1177/1753465814532304DOI Listing
June 2014

Practical phenotyping of difficult asthma.

Thorax 2014 Mar 31;69(3):299-301. Epub 2013 May 31.

Department of Respiratory Medicine, University Hospital of North Staffordshire, , Stoke-on-Trent, UK.

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http://dx.doi.org/10.1136/thoraxjnl-2013-203568DOI Listing
March 2014

Management dilemmas in acute pulmonary embolism.

Thorax 2014 Feb 16;69(2):174-80. Epub 2013 Dec 16.

Sheffield Pulmonary Vascular Disease Unit, Royal Hallamshire Hospital, , Sheffield, UK.

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http://thorax.bmj.com/lookup/doi/10.1136/thoraxjnl-2013-2046
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http://dx.doi.org/10.1136/thoraxjnl-2013-204667DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3913120PMC
February 2014

The yin and the yang of immunosuppression with inhaled corticosteroids.

Thorax 2013 Dec 8;68(12):1085-7. Epub 2013 Aug 8.

Academic Unit of Respiratory Medicine, University of Sheffield, , Sheffield, UK.

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http://dx.doi.org/10.1136/thoraxjnl-2013-203773DOI Listing
December 2013

Diesel exhaust particle exposure in vitro alters monocyte differentiation and function.

PLoS One 2012 7;7(12):e51107. Epub 2012 Dec 7.

Academic Unit of Respiratory Medicine, School of Medicine and Biomedical Sciences, University of Sheffield, Sheffield, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0051107PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3517601PMC
May 2013

Pulmonary hypertension: diagnosis and management.

BMJ 2013 Apr 16;346:f2028. Epub 2013 Apr 16.

National Pulmonary Hypertension Service Sheffield, Pulmonary Vascular Disease Unit, Royal Hallamshire Hospital, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield S10 2JF, UK.

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http://dx.doi.org/10.1136/bmj.f2028DOI Listing
April 2013

Pellino-1 selectively regulates epithelial cell responses to rhinovirus.

J Virol 2012 Jun 18;86(12):6595-604. Epub 2012 Apr 18.

Academic Unit of Respiratory Medicine, Department of Infection and Immunity, Faculty of Medicine, Dentistry and Health, University of Sheffield, Sheffield, United Kingdom.

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http://jvi.asm.org/cgi/doi/10.1128/JVI.06755-11
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http://dx.doi.org/10.1128/JVI.06755-11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3393558PMC
June 2012

TNF-related apoptosis-inducing ligand (TRAIL) regulates inflammatory neutrophil apoptosis and enhances resolution of inflammation.

J Leukoc Biol 2011 Nov 11;90(5):855-65. Epub 2011 May 11.

Academic Unit of Respiratory Medicine, Department of Infection and Immunity, University of Sheffield, Sheffield, UK.

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http://dx.doi.org/10.1189/jlb.0211062DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3644175PMC
November 2011

Role of interleukin-1 and MyD88-dependent signaling in rhinovirus infection.

J Virol 2011 Aug 18;85(15):7912-21. Epub 2011 May 18.

Academic Unit of Respiratory Medicine, School of Medicine and Biomedical Sciences, University of Sheffield, L Floor, Royal Hallamshire Hospital, Sheffield S10 2JF, United Kingdom.

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http://dx.doi.org/10.1128/JVI.02649-10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3147909PMC
August 2011

The role of TLRs in neutrophil activation.

Curr Opin Pharmacol 2011 Aug 6;11(4):397-403. Epub 2011 Jul 6.

Department of Infection and Immunity, University of Sheffield, Sheffield, United Kingdom.

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https://linkinghub.elsevier.com/retrieve/pii/S14714892110008
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http://dx.doi.org/10.1016/j.coph.2011.06.007DOI Listing
August 2011

Effective caspase inhibition blocks neutrophil apoptosis and reveals Mcl-1 as both a regulator and a target of neutrophil caspase activation.

PLoS One 2011 Jan 6;6(1):e15768. Epub 2011 Jan 6.

Medical Research Council Centre for Developmental and Biomedical Genetics, University of Sheffield, Sheffield, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0015768PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3017075PMC
January 2011

Temporal interleukin-1beta secretion from primary human peripheral blood monocytes by P2X7-independent and P2X7-dependent mechanisms.

J Biol Chem 2010 Jul 21;285(30):23147-58. Epub 2010 May 21.

Department of Cardiovascular Science, Royal Hallamshire Hospital, Beech Hill Rd., Sheffield S10 2RX, UK.

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http://dx.doi.org/10.1074/jbc.M109.072793DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2906308PMC
July 2010

A central role for monocytes in Toll-like receptor-mediated activation of the vasculature.

Immunology 2009 Sep;128(1):58-68

Cardiovascular Research Unit, School of Medicine and Biomedical Sciences, The University of Sheffield, Sheffield, UK.

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http://dx.doi.org/10.1111/j.1365-2567.2009.03071.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2747139PMC
September 2009

The generation of highly purified primary human neutrophils and assessment of apoptosis in response to Toll-like receptor ligands.

Methods Mol Biol 2009 ;517:191-204

School of Medicine and Biomedical Sciences, University of Sheffield, Sheffield S10 2JF, UK.

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http://link.springer.com/10.1007/978-1-59745-541-1_12
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http://dx.doi.org/10.1007/978-1-59745-541-1_12DOI Listing
May 2009

Basic science of the innate immune system and the lung.

Paediatr Respir Rev 2008 Dec 15;9(4):236-42. Epub 2008 Oct 15.

Academic Unit of Respiratory Medicine, School of Medicine and Biomedical Sciences, University of Sheffield, UK.

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http://dx.doi.org/10.1016/j.prrv.2008.03.002DOI Listing
December 2008

Ex vivo-expanded bone marrow CD34+ derived neutrophils have limited bactericidal ability.

Stem Cells 2008 Oct 31;26(10):2552-63. Epub 2008 Jul 31.

Academic Unit of Respiratory Medicine, Section of Infection, Inflammation and Immunity, School of Medicine and Biomedical Sciences, Royal Hallamshire Hospital, Sheffield, United Kingdom.

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http://dx.doi.org/10.1634/stemcells.2008-0328DOI Listing
October 2008

Differential and cell-type specific regulation of responses to Toll-like receptor agonists by ISO-1.

Immunology 2008 Sep 18;125(1):101-10. Epub 2008 Mar 18.

Academic Unit of Respiratory Medicine, School of Medicine and Biomedical Sciences, University of Sheffield, Sheffield, UK.

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http://dx.doi.org/10.1111/j.1365-2567.2008.02825.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2526264PMC
September 2008

Impairment of apoptotic cell engulfment by pyocyanin, a toxic metabolite of Pseudomonas aeruginosa.

Am J Respir Crit Care Med 2008 Jan 4;177(1):35-43. Epub 2007 Oct 4.

Academic Unit of Respiratory Medicine, School of Medicine and Biomedical Sciences, University of Sheffield, Sheffield S10 2JF, UK.

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http://dx.doi.org/10.1164/rccm.200612-1804OCDOI Listing
January 2008

Inhibition of neutrophil apoptosis by ATP is mediated by the P2Y11 receptor.

J Immunol 2007 Dec;179(12):8544-53

Academic Unit of Respiratory Medicine, School of Medicine and Biomedical Sciences, University of Sheffield, UK.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2292245PMC
http://dx.doi.org/10.4049/jimmunol.179.12.8544DOI Listing
December 2007

Incapacitating the immune system in cystic fibrosis.

Nat Med 2007 Dec;13(12):1417-8

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http://dx.doi.org/10.1038/nm1207-1417DOI Listing
December 2007

Practical and conceptual models of chronic obstructive pulmonary disease.

Proc Am Thorac Soc 2007 Dec;4(8):606-10

Academic Unit of Respiratory Medicine, Section of Infection, Inflammation, and Immunity, School of Medicine and Biomedical Sciences, University of Sheffield, Sheffield, United Kingdom.

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http://dx.doi.org/10.1513/pats.200707-086THDOI Listing
December 2007

A Bayesian approach to copy-number-polymorphism analysis in nuclear pedigrees.

Am J Hum Genet 2007 Oct 8;81(4):808-12. Epub 2007 Aug 8.

School of Medicine and Biomedical Sciences, University of Sheffield, Sheffield, UK.

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http://dx.doi.org/10.1086/520096DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2227930PMC
October 2007

Pathological networking: a new approach to understanding COPD.

Thorax 2007 Aug;62(8):733-8

Academic Unit of Respiratory Medicine, L Floor, Royal Hallamshire Hospital, Sheffield S10 2JF, UK.

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http://dx.doi.org/10.1136/thx.2007.077768DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2117289PMC
August 2007

Reducing the toll of inflammatory lung disease.

Chest 2007 May;131(5):1550-6

Academic Unit of Respiratory Medicine, School of Medicine and Biomedical Sciences, University of Sheffield, L Floor, Royal Hallamshire Hospital, Sheffield, UK.

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http://dx.doi.org/10.1378/chest.06-2869DOI Listing
May 2007

Contrary prostaglandins: the opposing roles of PGD2 and its metabolites in leukocyte function.

J Leukoc Biol 2007 Feb 17;81(2):372-82. Epub 2006 Oct 17.

Department of Asthma, Allergy and Respiratory Science, King's College London, 5th Floor Thomas Guy House, Guy's Hospital, London, UK.

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http://dx.doi.org/10.1189/jlb.0706424DOI Listing
February 2007

Targeting the networks that underpin contiguous immunity in asthma and chronic obstructive pulmonary disease.

Am J Respir Crit Care Med 2007 Feb 30;175(4):306-11. Epub 2006 Nov 30.

Academic Unit of Respiratory Medicine, School of Medicine and Biomedical Sciences, University of Sheffield, L Floor, Royal Hallamshire Hospital, Sheffield, UK.

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http://dx.doi.org/10.1164/rccm.200606-777PPDOI Listing
February 2007

Identifying and hurdling obstacles to translational research.

Nat Rev Immunol 2007 Jan;7(1):77-82

Academic Unit of Respiratory Medicine, School of Medicine and Biomedical Sciences, University of Sheffield, Royal Hallamshire Hospital, Sheffield S10 2JF, UK.

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http://dx.doi.org/10.1038/nri1999DOI Listing
January 2007

Cooperative molecular and cellular networks regulate Toll-like receptor-dependent inflammatory responses.

FASEB J 2006 Oct 25;20(12):2153-5. Epub 2006 Aug 25.

Academic Unit of Respiratory Medicine, Division of Genomic Medicine, University of Sheffield, Sheffield, S10 2JF, UK.

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http://dx.doi.org/10.1096/fj.06-5910fjeDOI Listing
October 2006

Tolerance to microbial TLR ligands: molecular mechanisms and relevance to disease.

J Endotoxin Res 2006 ;12(3):133-50

Department of Microbiology and Immunology, University of Maryland, Baltimore (UMB), Baltimore, Maryland 21201, USA.

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http://dx.doi.org/10.1179/096805106X102255DOI Listing
July 2006

"Dirty little secrets"--endotoxin contamination of recombinant proteins.

Immunol Lett 2006 Jul 11;106(1):1-7. Epub 2006 May 11.

MRC Centre for Inflammation Research, University of Edinburgh, UK.

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http://dx.doi.org/10.1016/j.imlet.2006.04.007DOI Listing
July 2006

Potentiation of TLR4 signalling by plasmin activity.

Biochem Biophys Res Commun 2006 Mar 10;341(2):299-303. Epub 2006 Jan 10.

Division of Genomic Medicine, University of Sheffield Medical School, University of Sheffield, Sheffield S10 2JF, UK.

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http://dx.doi.org/10.1016/j.bbrc.2005.12.188DOI Listing
March 2006

Granulocyte apoptosis in the pathogenesis and resolution of lung disease.

Clin Sci (Lond) 2006 Mar;110(3):293-304

Academic Unit of Respiratory Medicine, Division of Genomic Medicine, University of Sheffield, M Floor, Royal Hallamshire Hospital, Sheffield S10 2JF, U.K.

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http://clinsci.org/lookup/doi/10.1042/CS20050178
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http://dx.doi.org/10.1042/CS20050178DOI Listing
March 2006

9alpha,11beta-PGF2 and its stereoisomer PGF2alpha are novel agonists of the chemoattractant receptor, CRTH2.

FEBS Lett 2006 Jan 13;580(2):373-9. Epub 2005 Dec 13.

Leukocyte Biology Section, NHLI Division, Imperial College Faculty of Medicine, South Kensington, London SW7 2AZ, UK.

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http://dx.doi.org/10.1016/j.febslet.2005.11.052DOI Listing
January 2006

Endotoxin tolerance induces selective alterations in neutrophil function.

J Leukoc Biol 2005 Dec 21;78(6):1301-5. Epub 2005 Oct 21.

Division of Genomic Medicine, University of Sheffield, M Floor, Royal Hallamshire Hospital, Sheffield, S10 2JF, UK.

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http://dx.doi.org/10.1189/jlb.0405236DOI Listing
December 2005

The role of Toll-like receptors in the regulation of neutrophil migration, activation, and apoptosis.

Clin Infect Dis 2005 Nov;41 Suppl 7:S421-6

Division of Genomic Medicine, School of Medicine and Biomedical Sciences, University of Sheffield, Sheffield, UK.

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http://dx.doi.org/10.1086/431992DOI Listing
November 2005

Toll-like receptors and chronic lung disease.

Clin Sci (Lond) 2005 Aug;109(2):125-33

Academic Unit of Respiratory Medicine, Division of Genomic Medicine, University of Sheffield, M Floor, Royal Hallamshire Hospital, Sheffield, UK.

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http://dx.doi.org/10.1042/CS20050044DOI Listing
August 2005

The expression and roles of Toll-like receptors in the biology of the human neutrophil.

J Leukoc Biol 2005 Jun 22;77(6):886-92. Epub 2005 Feb 22.

Academic Units of Respiratory, Medicine and Cell Biology, Section of Functional Genomics, Division of Genomic Medicine, University of Sheffield, UK.

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http://dx.doi.org/10.1189/jlb.1104636DOI Listing
June 2005

The role of interleukin-8 and its receptors in inflammatory lung disease: implications for therapy.

Am J Respir Med 2002 ;1(1):19-25

Leukocyte Biology Section, Biomedical Sciences Division, Faculty of Medicine, Imperial College of Science, Technology & Medicine, South Kensington, London SW7 2AZ, UK.

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May 2005

Regulation of human neutrophil chemokine receptor expression and function by activation of Toll-like receptors 2 and 4.

Immunology 2005 May;115(1):90-8

Academic Units of Respiratory Medicine, Section of Functional Genomics, Division of Genomic Medicine, University of Sheffield, Sheffield, UK.

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http://dx.doi.org/10.1111/j.1365-2567.2005.02133.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1782127PMC
May 2005

Agonists of toll-like receptors 2 and 4 activate airway smooth muscle via mononuclear leukocytes.

Am J Respir Crit Care Med 2005 Apr 18;171(8):814-22. Epub 2005 Jan 18.

Academic Unit of Respiratory Medicine, Division of Genomic Medicine, University of Sheffield, M Floor, Royal Hallamshire Hospital, Sheffield, S10 2JF, UK.

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http://dx.doi.org/10.1164/rccm.200403-406OCDOI Listing
April 2005

The role of interleukin-1beta in direct and toll-like receptor 4-mediated neutrophil activation and survival.

Am J Pathol 2004 Nov;165(5):1819-26

Academic Unit of Respiratory Medicine, Division of Genomic Medicine, University of Sheffield, M Floor, Royal Hallamshire Hospital, Sheffield S10 2JF, United Kingdom.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1618681PMC
http://dx.doi.org/10.1016/s0002-9440(10)63437-2DOI Listing
November 2004

Toll-like receptor (TLR)2 and TLR4 agonists regulate CCR expression in human monocytic cells.

J Immunol 2004 Apr;172(8):4977-86

Section of Functional Genomics, Division of Genomic Medicine, University of Sheffield, Sheffield, United Kingdom.

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http://dx.doi.org/10.4049/jimmunol.172.8.4977DOI Listing
April 2004

CXCR1+CD4+ T cells in human allergic disease.

J Immunol 2004 Jan;172(1):268-73

Upper Respiratory Medicine, National Heart and Lung Institute, Imperial College, Dovehouse Street, London SW3 6LY, United Kingdom.

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http://dx.doi.org/10.4049/jimmunol.172.1.268DOI Listing
January 2004

CCR4 blockade does not inhibit allergic airways inflammation.

J Leukoc Biol 2003 Oct 15;74(4):558-63. Epub 2003 Jul 15.

Leukocyte Biology Section, Biomedical Sciences Division, Faculty of Medicine, Imperial College, London, United Kingdom.

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http://dx.doi.org/10.1189/jlb.0103030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3428841PMC
October 2003

Toll-like receptors in health and disease: complex questions remain.

J Immunol 2003 Aug;171(4):1630-5

Division of Genomic Medicine, University of Sheffield, Royal Hallamshire Hospital, Sheffield, United Kingdom.

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http://dx.doi.org/10.4049/jimmunol.171.4.1630DOI Listing
August 2003

Variations in eosinophil chemokine responses: an investigation of CCR1 and CCR3 function, expression in atopy, and identification of a functional CCR1 promoter.

J Immunol 2003 Jun;170(12):6190-201

Leukocyte Biology Section, Division of Biomedical Sciences, Faculty of Medicine, Imperial College London, London, United Kingdom.

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http://dx.doi.org/10.4049/jimmunol.170.12.6190DOI Listing
June 2003

Delta 12-prostaglandin J2, a plasma metabolite of prostaglandin D2, causes eosinophil mobilization from the bone marrow and primes eosinophils for chemotaxis.

J Immunol 2003 May;170(9):4752-8

Department of Experimental and Clinical Pharmacology, Karl Franzens University, Graz, Austria.

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http://dx.doi.org/10.4049/jimmunol.170.9.4752DOI Listing
May 2003

Selective roles for Toll-like receptor (TLR)2 and TLR4 in the regulation of neutrophil activation and life span.

J Immunol 2003 May;170(10):5268-75

Academic Unit of Respiratory Medicine, Section of Functional Genomics, Division of Genomic Medicine, University of Sheffield, Sheffield, United Kingdom.

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http://dx.doi.org/10.4049/jimmunol.170.10.5268DOI Listing
May 2003

Indomethacin causes prostaglandin D(2)-like and eotaxin-like selective responses in eosinophils and basophils.

J Biol Chem 2002 Jul 29;277(29):26012-20. Epub 2002 Apr 29.

Leukocyte Biology Section, Biomedical Sciences Division, Imperial College Faculty of Medicine, Imperial College of Science, Technology and Medicine, South Kensington, London SW7 2AZ, United Kingdom.

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http://dx.doi.org/10.1074/jbc.M201803200DOI Listing
July 2002

CCR4 in human allergen-induced late responses in the skin and lung.

Eur J Immunol 2002 Jul;32(7):1933-8

Upper Respiratory Medicine, National Heart and Lung Institute, Faculty of Medicine, Imperial College of Science, Technology and Medicine, London, GB.

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http://dx.doi.org/10.1002/1521-4141(200207)32:7<1933::AID-IMMU1933>3.0.CO;2-RDOI Listing
July 2002

Characterisation of the biological activity of recombinant equine eotaxin in vitro.

Cytokine 2002 Jul;19(1):27-30

Department of Pathology and Infectious Diseases, The Royal Veterinary College, University of London, Hawkshead Campus, Hertfordshire, AL9 7TA, UK.

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July 2002

Responses of leukocytes to chemokines in whole blood and their antagonism by novel CC-chemokine receptor 3 antagonists.

Am J Respir Crit Care Med 2002 Jun;165(12):1602-9

National Heart and Lung Institute, and Leukocyte Biology Section, Biomedical Sciences Division, Faculty of Medicine, Imperial College School of Medicine, London, United Kingdom.

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http://www.atsjournals.org/doi/abs/10.1164/rccm.200111-059OC
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http://dx.doi.org/10.1164/rccm.200111-059OCDOI Listing
June 2002

Toll-like receptor (TLR)2 and TLR4 in human peripheral blood granulocytes: a critical role for monocytes in leukocyte lipopolysaccharide responses.

J Immunol 2002 May;168(9):4701-10

Section of Functional Genomics, Division of Genomic Medicine, University of Sheffield, Sheffield, United Kingdom.

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http://dx.doi.org/10.4049/jimmunol.168.9.4701DOI Listing
May 2002

The identification, characterization, and distribution of guinea pig CCR4 and epitope mapping of a blocking antibody.

J Biol Chem 2002 Mar 27;277(9):6864-73. Epub 2001 Nov 27.

Leukocyte Biology Section, Biomedical Sciences Division, Faculty of Medicine, Imperial College of Science, Technology and Medicine, Exhibition Road, London SW7 2AZ, United Kingdom.

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http://dx.doi.org/10.1074/jbc.M109974200DOI Listing
March 2002