Ian S Hagemann

Ian S Hagemann

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Ian S Hagemann

Ian S Hagemann

Publications by authors named "Ian S Hagemann"

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Clinical Decision Support for Ovarian Carcinoma Subtype Classification: A Pilot Observer Study With Pathology Trainees.

Arch Pathol Lab Med 2019 Dec 9. Epub 2019 Dec 9.

From the Division of Imaging, Diagnostics, and Software Reliability, Office of Engineering and Science Laboratories (Dr Gavrielides and Ms Miller), and the Office of In Vitro Diagnostics and Radiological Health, Division of Molecular Genetics and Pathology (Dr Seidman), Center for Devices and Radiological Health, US Food and Drug Administration, Silver Spring, Maryland; the Department of Bioengineering, University of Maryland, College Park (Ms Miller); and the Departments of Pathology and Immunology (Drs Hagemann, Abdelal, Alipour, Chen, Salari, Sun, and Zhou) and Obstetrics and Gynecology (Dr Hagemann), Washington University School of Medicine, St Louis, Missouri. Ms Miller is currently with PCTEST Engineering Laboratory, Columbia, Maryland.

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http://dx.doi.org/10.5858/arpa.2019-0390-OADOI Listing
December 2019

Prospective assessment of the clinical benefit of a tailored cancer gene set built on a next-generation sequencing platform in patients with recurrent or metastatic head and neck cancer.

Med Oncol 2019 Dec 21;37(2):12. Epub 2019 Dec 21.

Division of Medical Oncology, Washington University School of Medicine, 660 South Euclid, Campus Box 8056, St. Louis, MO, 63110, USA.

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http://dx.doi.org/10.1007/s12032-019-1336-3DOI Listing
December 2019

Histogram analysis of en face scattering coefficient map predicts malignancy in human ovarian tissue.

J Biophotonics 2019 Nov 5;12(11):e201900115. Epub 2019 Aug 5.

Department of Biomedical Engineering, Washington University, St. Louis, Missouri.

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http://dx.doi.org/10.1002/jbio.201900115DOI Listing
November 2019

Evaluation of Ovarian Cancer: Initial Application of Coregistered Photoacoustic Tomography and US.

Radiology 2018 12 11;289(3):740-747. Epub 2018 Sep 11.

From the Department of Biomedical Engineering, Washington University, One Brookings Dr, Mail Box 1097, St Louis, MO 63130 (S.N., A.M., E.A., Q.Z.); Department of Pathology & Immunology (I.S.H.), Department of Obstetrics and Gynecology (I.S.H., M.A.P., D.G.M.), and Mallinckrodt Institute of Radiology (K.R., C.S., Q.Z.), Washington University School of Medicine, St Louis, Mo.

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http://dx.doi.org/10.1148/radiol.2018180666DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6283286PMC
December 2018

Clinical Targeted Next-Generation Sequencing Shows Increased Mutational Load in Endometrioid-type Endometrial Adenocarcinoma With Deficient DNA Mismatch Repair.

Int J Gynecol Pathol 2018 Nov;37(6):581-589

Departments of Pathology and Immunology (P.J.L., S.M., E.J.D., J.W.H., I.S.H.) Obstetrics and Gynecology (I.S.H.), Washington University School of Medicine, St Louis, Missouri.

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http://Insights.ovid.com/crossref?an=00004347-900000000-9924
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http://dx.doi.org/10.1097/PGP.0000000000000459DOI Listing
November 2018

Multiple Myeloma Presenting as Massive Amyloid Deposition in a Parathyroid Gland Associated with Amyloid Goiter: A Medullary Thyroid Carcinoma Mimic on Intra-operative Frozen Section.

Head Neck Pathol 2018 Jun 6;12(2):269-273. Epub 2017 Sep 6.

Department of Pathology and Immunology, Washington University School of Medicine, 660 S. Euclid Ave., Campus Box 8118, St. Louis, MO, USA.

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http://dx.doi.org/10.1007/s12105-017-0853-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5953875PMC
June 2018

Quantitative multispectral optical evaluation of human ovarian tissue using spatial frequency domain imaging.

Biomed Opt Express 2018 May 30;9(5):2451-2456. Epub 2018 Apr 30.

Department of Biomedical Engineering, Washington University in St. Louis, St. Louis, MO 63130, USA.

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http://dx.doi.org/10.1364/BOE.9.002451DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5946801PMC
May 2018

p16 Immunohistochemistry Is Not Always Required For Accurate Diagnosis of Grade 2 Squamous Intraepithelial Lesions.

J Low Genit Tract Dis 2018 Apr;22(2):104-109

Division of Anatomic and Molecular Pathology, Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO.

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http://dx.doi.org/10.1097/LGT.0000000000000370DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5868428PMC
April 2018

Cervical clear cell adenocarcinoma with an exceptionally low proliferation index: Report of a case.

Gynecol Oncol Rep 2018 Feb 2;23:16-19. Epub 2018 Jan 2.

Department of Pathology & Immunology, Washington University School of Medicine, St. Louis, MO, United States.

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http://dx.doi.org/10.1016/j.gore.2017.12.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5760463PMC
February 2018

Association of Li-Fraumeni Syndrome With Small Cell Carcinoma of the Ovary, Hypercalcemic Type and Concurrent Pleomorphic Liposarcoma of the Cervix.

Int J Gynecol Pathol 2017 Nov;36(6):593-599

Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO.

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http://dx.doi.org/10.1097/PGP.0000000000000365DOI Listing
November 2017

Endometrial adenosarcoma in the setting of a germline mutation: A case report.

Gynecol Oncol Rep 2017 May 11;20:121-124. Epub 2017 Apr 11.

Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Washington University School of Medicine, Alvin J. Siteman Cancer Center, St Louis, MO, USA.

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http://dx.doi.org/10.1016/j.gore.2017.04.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5397585PMC
May 2017

Osteolipoma of the knee.

Radiol Case Rep 2017 Mar 23;12(1):124-129. Epub 2016 Nov 23.

Department of Radiology, Mallinckrodt Institute of Radiology, 510 S Kingshighway Blvd, St. Louis, MO 63110, USA.

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http://dx.doi.org/10.1016/j.radcr.2016.10.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5310264PMC
March 2017

Whole-Genome DNA Methylation Profiling Identifies Epigenetic Signatures of Uterine Carcinosarcoma.

Neoplasia 2017 02 12;19(2):100-111. Epub 2017 Jan 12.

Department of Genetics, Washington University School of Medicine, St. Louis, MO; Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, MO.

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http://dx.doi.org/10.1016/j.neo.2016.12.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5237802PMC
February 2017

Spectrum of mutations in leiomyosarcomas identified by clinical targeted next-generation sequencing.

Exp Mol Pathol 2017 02 14;102(1):156-161. Epub 2017 Jan 14.

Department of Pathology and Immunology, Washington University, St. Louis, MO, United States. Electronic address:

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http://dx.doi.org/10.1016/j.yexmp.2017.01.012DOI Listing
February 2017

Molecular Testing in Breast Cancer: A Guide to Current Practices.

Authors:
Ian S Hagemann

Arch Pathol Lab Med 2016 Aug;140(8):815-24

From the Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri. Presented at the 2nd Princeton Integrated Pathology Symposium: Breast Pathology; February 8, 2015; Plainsboro, New Jersey.

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http://dx.doi.org/10.5858/arpa.2016-0051-RADOI Listing
August 2016

A common founding clone with TP53 and PTEN mutations gives rise to a concurrent germ cell tumor and acute megakaryoblastic leukemia.

Cold Spring Harb Mol Case Stud 2016 Jan;2(1):a000687

McDonnell Genome Institute, Washington University School of Medicine, St. Louis, Missouri 63110, USA;; Division of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri 63110, USA;

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http://dx.doi.org/10.1101/mcs.a000687DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4849848PMC
January 2016

Diagnostic yield of targeted next generation sequencing in various cancer types: an information-theoretic approach.

Cancer Genet 2015 Sep 29;208(9):441-7. Epub 2015 May 29.

Genomics and Pathology Services, Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.

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http://dx.doi.org/10.1016/j.cancergen.2015.05.030DOI Listing
September 2015

The Cancer Genomics Resource List 2014.

Arch Pathol Lab Med 2015 Aug 1;139(8):989-1008. Epub 2014 Dec 1.

From the Department of Pathology, Microbiology, and Immunology, Vanderbilt University School of Medicine, Nashville, Tennessee (Dr Zutter); the Department of Pathology, Clarient Diagnostic Services, Aliso Viejo, California (Dr Bloom); the Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis (Dr Cheng); the Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri (Drs Hagemann and Pfeifer); Surveys, College of American Pathologists, Northfield, Illinois (Dr Kaufman); the Department of Pathology, Emory University, Atlanta, Georgia (Dr Krasinskas); the Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston (Dr Lazar); the Department of Pathology and Laboratory Medicine, Fletcher Allen Health Care, Burlington, Vermont (Dr Leonard); the Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts (Dr Lindeman); the Department of Pathology, Mayo Clinic, Rochester, Minnesota (Dr Moyer); Molecular and Genomic Pathology Laboratory, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania (Dr Nikiforova); the Department of Pathology, NorthShore University Health System, Evanston, Illinois (Dr Nowak); the Department of Pathology and Cell Biology, Columbia University Medical Center, New York, New York (Dr Sepulveda); the Department of Pathology, Case Medical Center/Case Western Reserve University, Cleveland, Ohio (Dr Willis); and the Department of Molecular Pathology and Hematopathology, University of Minnesota, Minneapolis (Dr Yohe).

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http://dx.doi.org/10.5858/arpa.2014-0330-CPDOI Listing
August 2015

T-cell clonality assessment by next-generation sequencing improves detection sensitivity in mycosis fungoides.

J Am Acad Dermatol 2015 Aug 3;73(2):228-36.e2. Epub 2015 Jun 3.

Washington University School of Medicine, Saint Louis, Missouri. Electronic address:

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http://dx.doi.org/10.1016/j.jaad.2015.04.030DOI Listing
August 2015

The Ovarian Cancer Chemokine Landscape Is Conducive to Homing of Vaccine-Primed and CD3/CD28-Costimulated T Cells Prepared for Adoptive Therapy.

Clin Cancer Res 2015 Jun 23;21(12):2840-50. Epub 2015 Feb 23.

Ovarian Cancer Research Center, University of Pennsylvania, Philadelphia, Pennsylvania. Ludwig Cancer Research Center, University of Lausanne, Lausanne, Switzerland. Department of Oncology, University Hospital of Lausanne, Lausanne, Switzerland.

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http://dx.doi.org/10.1158/1078-0432.CCR-14-2777DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4987088PMC
June 2015

Molecular pathology of hereditary and sporadic medullary thyroid carcinomas.

Am J Clin Pathol 2015 Jun;143(6):768-77

From the Departments of Pathology and.

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http://dx.doi.org/10.1309/AJCPHWACTTUYJ7DDDOI Listing
June 2015

Optimal sampling of grossly normal omentum in staging of gynecologic malignancies.

Int J Gynecol Pathol 2015 May;34(3):281-7

Department of Pathology and Immunology (S.L.S., I.S.H.), Division of Anatomic and Molecular Pathology Department of Obstetrics and Gynecology (I.S.H.), Washington University School of Medicine, St. Louis, Missouri.

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http://dx.doi.org/10.1097/PGP.0000000000000148DOI Listing
May 2015

Seminoma presenting as renal mass, inferior vena caval thrombus, and regressed testicular mass.

Case Rep Urol 2015 29;2015:835962. Epub 2015 Jan 29.

Division of Urologic Surgery, Department of Surgery, Washington University School of Medicine, Saint Louis, MO, USA.

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http://dx.doi.org/10.1155/2015/835962DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4325215PMC
February 2015

Comparative DNA methylome analysis of endometrial carcinoma reveals complex and distinct deregulation of cancer promoters and enhancers.

BMC Genomics 2014 Oct 6;15:868. Epub 2014 Oct 6.

Department of Genetics, Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St, Louis MO 63108, USA.

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http://dx.doi.org/10.1186/1471-2164-15-868DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4198682PMC
October 2014

Tumor endothelium FasL establishes a selective immune barrier promoting tolerance in tumors.

Nat Med 2014 Jun 4;20(6):607-15. Epub 2014 May 4.

1] Ovarian Cancer Research Center, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA. [2].

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http://www.nature.com/articles/nm.3541
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http://dx.doi.org/10.1038/nm.3541DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4060245PMC
June 2014

Diagnostic utility of targeted next-generation sequencing in problematic cases.

Am J Surg Pathol 2014 Apr;38(4):534-41

Department of Pathology and Immunology, Washington University in St Louis, St Louis, MO.

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http://dx.doi.org/10.1097/PAS.0000000000000161DOI Listing
April 2014

Stabilization of disease after targeted therapy in a thymic carcinoma with KIT mutation detected by clinical next-generation sequencing.

J Thorac Oncol 2014 Feb;9(2):e12-6

*Genomics and Pathology Services, Department of Pathology and Immunology, †Section of Medical Oncology, Department of Medicine, and ‡Mallinckrodt Institute of Radiology, Washington University, St. Louis, Missouri.

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http://dx.doi.org/10.1097/JTO.0b013e3182a7d22eDOI Listing
February 2014

Design of targeted, capture-based, next generation sequencing tests for precision cancer therapy.

Cancer Genet 2013 Dec 22;206(12):420-31. Epub 2013 Nov 22.

Genomics and Pathology Services, Division of Laboratory and Genomic Medicine, Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.

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http://dx.doi.org/10.1016/j.cancergen.2013.11.003DOI Listing
December 2013

Primary human ovarian epithelial cancer cells broadly express HER2 at immunologically-detectable levels.

PLoS One 2012 26;7(11):e49829. Epub 2012 Nov 26.

Ovarian Cancer Research Center, Department of Obstetrics and Gynecology, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0049829PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3506636PMC
May 2013

Mammaglobin expression in gynecologic adenocarcinomas.

Hum Pathol 2013 Apr 17;44(4):628-35. Epub 2012 Oct 17.

Division of Anatomic and Molecular Pathology, Department of Pathology and Immunology, Washington University, St Louis, MO 63110, USA.

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http://dx.doi.org/10.1016/j.humpath.2012.07.013DOI Listing
April 2013

Redirected antitumor activity of primary human lymphocytes transduced with a fully human anti-mesothelin chimeric receptor.

Mol Ther 2012 Mar 29;20(3):633-43. Epub 2011 Nov 29.

Department of Obstetrics and Gynecology, Ovarian Cancer Research Center, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.

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http://dx.doi.org/10.1038/mt.2011.256DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3293635PMC
March 2012

Prognostic significance of tumor-infiltrating T cells in ovarian cancer: a meta-analysis.

Gynecol Oncol 2012 Feb 29;124(2):192-8. Epub 2011 Oct 29.

Ovarian Cancer Research Center, University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1016/j.ygyno.2011.09.039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3298445PMC
February 2012

Aberrant connexin 43 and 26 expression in cervical dysplasia.

Anal Quant Cytol Histol 2012 Feb;34(1):28-40

Section of Surgical Pathology, Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, 3400 Spruce Street, Philadelphia, Pennsylvania 19101, USA.

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February 2012

Risk of occult malignancy in morcellated hysterectomy: a case series.

Int J Gynecol Pathol 2011 Sep;30(5):476-83

Section of Surgical Pathology, Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA 19104, USA. .

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http://dx.doi.org/10.1097/PGP.0b013e3182107ecfDOI Listing
September 2011

Tumour hypoxia promotes tolerance and angiogenesis via CCL28 and T(reg) cells.

Nature 2011 Jul 13;475(7355):226-30. Epub 2011 Jul 13.

Ovarian Cancer Research Center, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.

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http://dx.doi.org/10.1038/nature10169DOI Listing
July 2011

A retrospective comparison of 2 methods of intraoperative margin evaluation during partial nephrectomy.

J Urol 2009 Feb 13;181(2):500-5. Epub 2008 Dec 13.

Department of Pathology and Immunology, Division of Anatomic and Molecular Pathology, Washington University School of Medicine, St Louis, Missouri, USA.

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http://dx.doi.org/10.1016/j.juro.2008.10.020DOI Listing
February 2009

Benjamin Franklin's risk factors for gout and stones: from genes and diet to possible lead poisoning.

Proc Am Philos Soc 2008 Jun;152(2):189-206

Washington University in St. Louis, USA.

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June 2008

Structure of the complement factor 5a receptor-ligand complex studied by disulfide trapping and molecular modeling.

J Biol Chem 2008 Mar 14;283(12):7763-75. Epub 2008 Jan 14.

Department of Medicine, Washington University School of Medicine, St. Louis, Missouri 63110, USA.

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http://dx.doi.org/10.1074/jbc.M709467200DOI Listing
March 2008

A careful look at community CPR training.

Authors:
Ian S Hagemann

Mo Med 2007 Nov-Dec;104(6):481-4

Medical Scientist Training Program, Washington University School of Medicine, USA.

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February 2008

Comparison of the retinitis pigmentosa mutations in rhodopsin with a functional map of the C5a receptor.

Vision Res 2006 Dec 8;46(27):4519-31. Epub 2006 Sep 8.

Department of Medicine, Washington University in St. Louis, Campus Box 8127, 660 S. Euclid Ave., St. Louis, MO 63110, USA.

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http://dx.doi.org/10.1016/j.visres.2006.07.010DOI Listing
December 2006

Random mutagenesis of the complement factor 5a (C5a) receptor N terminus provides a structural constraint for C5a docking.

J Biol Chem 2006 Dec 5;281(48):36783-92. Epub 2006 Oct 5.

Departments of Medicine and Molecular Biology and Pharmacology, Washington University School of Medicine, St. Louis, Missouri 63110, USA.

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http://dx.doi.org/10.1074/jbc.M607686200DOI Listing
December 2006